CN107951603A - A kind of biodegradable stent system for crotch branch vessel - Google Patents
A kind of biodegradable stent system for crotch branch vessel Download PDFInfo
- Publication number
- CN107951603A CN107951603A CN201711366229.7A CN201711366229A CN107951603A CN 107951603 A CN107951603 A CN 107951603A CN 201711366229 A CN201711366229 A CN 201711366229A CN 107951603 A CN107951603 A CN 107951603A
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- Prior art keywords
- sacculus
- stent
- supporting part
- branch vessel
- biodegradable stent
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- 210000004204 blood vessel Anatomy 0.000 claims abstract description 38
- 239000000463 material Substances 0.000 claims description 8
- 238000010146 3D printing Methods 0.000 claims description 6
- 238000007493 shaping process Methods 0.000 claims description 6
- 238000005452 bending Methods 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 229910003460 diamond Inorganic materials 0.000 claims description 4
- 239000010432 diamond Substances 0.000 claims description 4
- 239000004677 Nylon Substances 0.000 claims description 3
- 238000007664 blowing Methods 0.000 claims description 3
- 229920001778 nylon Polymers 0.000 claims description 3
- 238000009954 braiding Methods 0.000 claims description 2
- 238000003698 laser cutting Methods 0.000 claims description 2
- 230000017531 blood circulation Effects 0.000 abstract description 16
- 230000003902 lesion Effects 0.000 abstract description 14
- 230000007774 longterm Effects 0.000 abstract description 11
- 230000005012 migration Effects 0.000 abstract description 5
- 238000013508 migration Methods 0.000 abstract description 5
- 238000010586 diagram Methods 0.000 description 30
- 238000000034 method Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- 201000000057 Coronary Stenosis Diseases 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010011089 Coronary artery stenosis Diseases 0.000 description 1
- 229910001021 Ferroalloy Inorganic materials 0.000 description 1
- 229910000861 Mg alloy Inorganic materials 0.000 description 1
- 230000003409 anti-rejection Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035485 pulse pressure Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002966 stenotic effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a kind of biodegradable stent system for crotch branch vessel, including biodegradable stent and special-shaped sacculus, biodegradable stent to include：Extend along branch vessel, being positioned over the stent supporting part in branch vessel；Positioned at the bottom of stent supporting part, being anchored to the bracket fixture portions of the junction of major blood vessel and branch vessel；Special-shaped sacculus includes：Extend along major blood vessel, the sacculus fixed part of major blood vessel can be closely attached on；It is connected with sacculus fixed part and the sacculus supporting part on the inside of the stent supporting part；Sacculus supporting part can supporting support supporting part extend out, to realize that stent supporting part is adjacent to branch vessel.Above-mentioned biodegradable stent system, by being suppressed to special-shaped sacculus, bracket fixture portions are caused to be plastically deformed, it is set to be close to major blood vessel wall, it ensure that branch vessel lesion is completely covered in biodegradable stent, bracket fixture portions are avoided to the obstruction of major blood vessel blood flow, avoid the stent migration under long-term branch vessel blood flow impact.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of biodegradable stent for crotch branch vessel
System.
Background technology
Cardiovascular and cerebrovascular disease has become the big cause of the death that beats the world.At present, for the treatment method of ischemic heart disease
Mainly there are three kinds：Using the Primary Care of medicine, carry out the operative treatment of coronary artery bypass grafting, by inserting coronary artery bracket etc. so as to solve
Except the interventional treatment of coronary stenosis.Above-mentioned several treatment methods all achieve obvious effect in terms of coronary artery stenosis is treated
Fruit, but each still suffer from the problem of some are notable.
Wherein, percutaneous transluminal coronary stent implantation is that stent system is transported to target area, sacculus by way of puncturing and intervening
Expansion release stent, struts stenotic lesion blood vessel, recovers blood supply, treat ischemic heart disease.The stent clinically used at present
It is broadly divided into metallic support and biodegradable stent.Metallic support can strongly strut lesion vessels, relief of symptoms, but its permanent plant
Enter human body, it is necessary to which long-term use of dual anti-and anti-rejection medication, patient's body and financial burden are heavier.Meanwhile metallic support is long-term
Patency rate it is relatively low, long term needs further treatment.After biodegradable stent implantation human body, lesion vessels can be strutted, and pass through
Endothelial cell growth covered stent, stent are then gradually degraded, and blood vessel recovers original anatomic morphological, and then recovery blood vessel at a specified future date
Shrink diastolic function.
However, when biodegradable stent common in the art acts on the branch vessel of bifurcated lesions, it is ensured that stent is released
Spermiation truly has great difficulty, and possibly lesion region can not be completely covered in the stent after implantation；The near-end of stent is possibly into trunk
Blood vessel, hinders normal blood flow, causes hemadostewnosis or occlusion；Traditional biodegradable stent is elapsed with the time, to the branch of vascular wall
Support force gradually reduces, and may be migrated under the impact of long-term blood flow.
In conclusion how to efficiently solve biodegradable stent when treating crotch branch vessel lesion, not exclusively cover
Lid lesion region, hinder the problems such as major blood vessel normal blood flow, impact lower carriage migration of long-term blood flow, is current art technology
Personnel's urgent problem.
The content of the invention
The object of the present invention is to provide a kind of biodegradable stent system for crotch branch vessel, with solve it is existing can
Degrade after stenter to implant human body, endless all standing lesion region, hinder to drop under major blood vessel normal blood flow, the impact of long-term blood flow
The problem of solving stent migration.
To achieve the above object, the present invention provides a kind of biodegradable stent system for crotch branch vessel, including
Biodegradable stent and special-shaped sacculus,
The biodegradable stent includes：
Extend along branch vessel, being positioned over the stent supporting part in branch vessel；
Consolidate positioned at the bottom of the stent supporting part, to be anchored to the stent of the junction of major blood vessel and branch vessel
Determine portion；
The abnormity sacculus includes：
Extend along major blood vessel, the sacculus fixed part of major blood vessel can be closely attached on；
It is connected with the sacculus fixed part and the sacculus supporting part on the inside of the stent supporting part；The sacculus branch
Support part can support the stent supporting part to extend out, to realize that the stent supporting part is adjacent to branch vessel.
Relative to above-mentioned background technology, provided by the present invention for the biodegradable stent system of crotch branch vessel, adopt
Biodegradable stent is expanded with special-shaped sacculus, it is ensured that lesion region can be completely covered in stent supporting part and bracket fixture portions；
Sacculus fixed part can cause bracket fixture portions to be plastically deformed at the same time, be adjacent to major blood vessel, avoid to major blood vessel blood flow
Obstruction；The deformed stereochemical structure of bracket fixture portions plays the role of grappling, and avoiding can drop under the impact of long-term blood flow
Solve the migration of stent.
Preferably, the bracket fixture portions are specially multiple grappling pawls for being uniformly distributed in the stent supporting part bottom.
Preferably, the stent supporting part is specially the cylindricality reticulate body with open loop hole or closed loop hole.
Preferably, the grappling pawl is specifically in straight rod-shaped, bending rod, triangle or diamond shape.
Preferably, the sacculus supporting part is arranged on near-end, stage casing or the distal end of the sacculus fixed part.
Preferably, the near-end of the sacculus fixed part has respectively with distal end dominates silk with the near-end passed through for dominating silk
The main guidewire port of mouth and distal end；The near-end of the sacculus fixed part and the distal end of the sacculus supporting part have with for branch respectively
The proximal limbs guidewire port and far-end branch guidewire port that seal wire passes through.
Preferably, before pressure is held, the sacculus supporting part sequentially passes through the bracket fixture portions and the stent supporting part；
And the transitional region between the bracket fixture portions and the stent supporting part is fixed with the sacculus supporting part and the sacculus
Transitional region between portion fits.
Preferably, the biodegradable stent is made of PLA or PCL materials；The abnormity sacculus is made of nylon material.
Preferably, the biodegradable stent is laser cutting, weaves, 3D printing shaping that the abnormity sacculus is blowing, 3D
Printing shaping.
Preferably, the biodegradable stent and the special-shaped sacculus can radially be pressed by one holds.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is attached drawing needed in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
The embodiment of invention, for those of ordinary skill in the art, without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
The structural representation for the biodegradable stent system for crotch branch vessel that Fig. 1 is provided by the embodiment of the present invention
Figure；
Fig. 2 (a) is a kind of floor map of the biodegradable stent of embodiment；
Fig. 2 (b) is the schematic perspective view of the biodegradable stent in Fig. 2 (a)；
Fig. 3 (a) is the schematic diagram of the first embodiment of the stent supporting part in Fig. 1；
Fig. 3 (b) is the schematic diagram of second of embodiment of the stent supporting part in Fig. 1；
Fig. 3 (c) is the schematic diagram of the third embodiment of the stent supporting part in Fig. 1；
Fig. 3 (d) is the schematic diagram of the 4th kind of embodiment of the stent supporting part in Fig. 1；
Fig. 3 (e) is the schematic diagram of the 5th kind of embodiment of the stent supporting part in Fig. 1；
Fig. 3 (f) is the schematic diagram of the 6th kind of embodiment of the stent supporting part in Fig. 1；
Fig. 4 (a) is the schematic diagram of the first embodiment of the bracket fixture portions in Fig. 1；
Fig. 4 (b) is the schematic diagram of second of embodiment of the bracket fixture portions in Fig. 1；
Fig. 4 (c) is the schematic diagram of the third embodiment of the bracket fixture portions in Fig. 1；
Fig. 4 (d) is the schematic diagram of the 4th kind of embodiment of the bracket fixture portions in Fig. 1；
Fig. 4 (e) is the schematic diagram of the 5th kind of embodiment of the bracket fixture portions in Fig. 1；
Fig. 5 (a) is a kind of general illustration of the special-shaped sacculus of embodiment；
Fig. 5 (b) is the detailed schematic of the special-shaped sacculus in Fig. 5 (a)；
Fig. 6 is structure diagram of the biodegradable stent system before pressure is held in Fig. 1；
Fig. 7 is structure diagram of the biodegradable stent system when pressure is held in Fig. 1；
Fig. 8 is structure diagram of the biodegradable stent system in conveying in Fig. 1；
Fig. 9 is structure diagram of the biodegradable stent system in release in Fig. 1.
Embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work
Embodiment, belongs to the scope of protection of the invention.
In order to make those skilled in the art more fully understand the present invention program, below in conjunction with the accompanying drawings and it is embodied
The present invention is described in further detail for mode.
The degradable branch for crotch branch vessel provided to Fig. 9, Fig. 1 by the embodiment of the present invention is be provided
The structure diagram of frame system；Fig. 2 (a) is a kind of floor map of the biodegradable stent of embodiment；Fig. 2 (b) is Fig. 2
(a) schematic perspective view of the biodegradable stent in；Fig. 3 (a) is the first embodiment of the stent supporting part in Fig. 1
Schematic diagram；Fig. 3 (b) is the schematic diagram of second of embodiment of the stent supporting part in Fig. 1；Fig. 3 (c) is in Fig. 1
The schematic diagram of the third embodiment of stent supporting part；Fig. 3 (d) is the 4th kind of the stent supporting part in Fig. 1 specific
The schematic diagram of embodiment；Fig. 3 (e) is the schematic diagram of the 5th kind of embodiment of the stent supporting part in Fig. 1；Fig. 3 (f)
For the schematic diagram of the 6th kind of embodiment of the stent supporting part in Fig. 1；Fig. 4 (a) is the of the bracket fixture portions in Fig. 1
A kind of schematic diagram of embodiment；Fig. 4 (b) is the signal of second of embodiment of the bracket fixture portions in Fig. 1
Figure；Fig. 4 (c) is the schematic diagram of the third embodiment of the bracket fixture portions in Fig. 1；Fig. 4 (d) is the stent in Fig. 1
The schematic diagram of 4th kind of embodiment of fixed part；Fig. 4 (e) is the 5th kind of specific implementation of the bracket fixture portions in Fig. 1
The schematic diagram of mode；Fig. 5 (a) is a kind of general illustration of the special-shaped sacculus of embodiment；Fig. 5 (b) is different in Fig. 5 (a)
The detailed schematic of shape sacculus；Fig. 6 is structure diagram of the biodegradable stent system before pressure is held in Fig. 1；Fig. 7 is in Fig. 1
Biodegradable stent system pressure hold when structure diagram；Fig. 8 is structure of the biodegradable stent system in conveying in Fig. 1
Schematic diagram；Fig. 9 is structure diagram of the biodegradable stent system in release in Fig. 1.
A kind of biodegradable stent system for crotch branch vessel provided by the invention, as shown in Figure 1, main bag
Include biodegradable stent 1 and special-shaped sacculus 2；Wherein, biodegradable stent 1 includes stent supporting part 11 and bracket fixture portions 12, abnormity
Sacculus 2 includes sacculus fixed part 21 and sacculus supporting part 22, and biodegradable stent 1 and the special-shaped use of sacculus 2 can be implanted into human body
Interior material is made, and both of which is by can radially be pressed the material held to be made；Biodegradable stent 1 can be used and is respectively adopted
The degradable material such as PLA, PCL, PGA, PLGA, magnesium alloy, ferroalloy is made, and special-shaped sacculus 2 can use the macromolecules such as nylon
Material is made.
Stent supporting part 11 extends along branch vessel 42, substantially cylindrical, for being placed in branch vessel 42；Stent
Fixed part 12 is located at the bottom of stent supporting part 11, has the function of to extend out, and can be anchored to branch vessel 42 and major blood vessel
41 junction.Wherein, biodegradable stent 1 is preferably and is cut by laser shaping to set, it is, of course, also possible to using braiding, 3D printing
The modes such as shaping are made.Special-shaped sacculus 2 can then use the modes such as blowing, 3D printing to be made.
Sacculus fixed part 21 extends along major blood vessel 41, and the both ends of sacculus fixed part 21 are located at the two of branch vessel 42 respectively
Side, and it is substantially cylindrical, the inner wall of major blood vessel 41 can be closely attached on；Sacculus supporting part 22 is connected with sacculus fixed part 21,
Both have certain angle, and special-shaped sacculus 2 is preferably that blow molding is set；Sacculus supporting part 22 extends along branch vessel 42, position
In the inner side of stent supporting part 11；Sacculus fixed part 21 and sacculus supporting part 22 pressurising and can be expanded, when sacculus fixed part
21 and sacculus supporting part 22 expand after, sacculus fixed part 21 can be close to the inner wall of major blood vessel 41, and sacculus supporting part 22 exists
Stent supporting part 11 is driven to extend out while expansion so that stent supporting part 11 and the inner wall of branch vessel 42 fit closely, and
Bracket fixture portions 12 positioned at 11 bottom of stent supporting part are anchored to 42 He of branch vessel under the action of the expansion of special-shaped sacculus 2
The junction of major blood vessel 41, as shown in Figure 9.For above-mentioned Plenum Process, it can use and be filled with physiological saline or contrast agent
Realized Deng liquid medium.
So set, after the 2 pressurising expansion of special-shaped sacculus, bracket fixture portions 12 are stretched out by branch vessel 42, and plasticity occurs
Deformation, is in cylinder planar along major blood vessel 41, the madial wall of major blood vessel 41 is anchored to, that is, bracket fixture portions 12 are in abnormity
Deformed upon under the action of 2 pressurising of sacculus expansion, the stereochemical structure after deformation plays the role of grappling, avoids in long-term blood flow
Impact is lower, and there is a phenomenon where biodegradable stent 1 migrates.
Attached drawing 2 (a) illustrates the plane and stereochemical structure of biodegradable stent 1, stent supporting part to attached drawing 2 (b) respectively
Stent supporting part near-end 111 is equipped between 11 and bracket fixture portions 12, according to attached drawing 1, stent supporting part near-end 111 is perpendicular
Nogata is upwards between stent supporting part 11 and bracket fixture portions 12, namely biodegradable stent 1 sets gradually branch from top to bottom
Frame supporting part 11, stent supporting part near-end 111 and bracket fixture portions 12.
As shown in attached drawing 3 (a) to attached drawing 3 (f), stent supporting part 11 is specially the cylindricality net with open loop hole or closed loop hole
Shape body.That is, stent supporting part 11 is overall cylindrical, to support branch vessel 42, and the side wall of stent supporting part 11 has
There is mesh, mesh is open loop hole or closed loop hole, and geomery there can be diversified forms；So set, it can realize in abnormity
Stent supporting part 11 extends out under the action of 2 pressurising of sacculus expansion, so that it is guaranteed that stent supporting part 11 is fitted closely in branch
The madial wall of blood vessel 42；At the same time, stent supporting part 11 has preferable radial support power and compliance, works as biodegradable stent
There is higher tube chamber patency rate after system implantation.
As shown in attached drawing 4 (a) to attached drawing 4 (e), bracket fixture portions 12 could be provided as grappling pawl, preferably by multiple grapplings
Pawl is uniformly distributed in stent supporting part near-end 111；As can be seen that grappling pawl can be straight rod-shaped, bending rod, triangle or
Diamond shape；Wherein, the length of straight rod-shaped, bending size of the bending curvature of rod, the type of triangle and diamond shape etc. can be with
It is decided according to the actual requirements, does not make specific restriction herein；So set, in implantation biodegradable stent system, pressure is needed to hold
When biodegradable stent 1 and special-shaped sacculus 2, there is less peak stress during pressure is held, biodegradable stent 1 in process of expansion
Lesion can be completely covered, while bracket fixture portions 12 can be close to major blood vessel 42, avoid the resistance to major blood vessel blood flow
Hinder；Deformed bracket fixture portions 12 play the role of grappling, avoid the biodegradable stent 1 under the impact of long-term blood flow and move
Move.
By taking attached drawing 4 (a) to attached drawing 4 (e) as an example, the lower position of grappling pawl, the position that can be extended out, fits in
41 madial wall of major blood vessel, and the tip position of grappling pawl is located in branch vessel 42, namely grappling pawl integrally realizes grappling
Purpose in branch vessel 42 and the junction of major blood vessel 41.
As shown in attached drawing 5 (a) to attached drawing 5 (b), sacculus supporting part 22 can be arranged on sacculus fixed part 21 near-end 212, in
Section 215 or distal end 211.Attached drawing 5 (a) shows that sacculus supporting part 22 is arranged on 21 stage casing 215 of sacculus fixed part with attached drawing 5 (b)
Situation；The near-end 212 of sacculus fixed part 21 both ends as described above with distal end 211, the near-end 212 of sacculus fixed part 21
It is located at the both sides of branch vessel 42 respectively with distal end 211.
The near-end 212 of sacculus fixed part 21 has the main guidewire port of the main guidewire port 214 of near-end and distal end with distal end 211 respectively
213, the main guidewire port 213 of the main guidewire port 214 of near-end and distal end can be run through by dominating silk 31, as shown in Figure of description 8；Sacculus is consolidated
The near-end 212 for determining portion 21 is additionally provided with proximal limbs guidewire port 224, and the distal end 221 of sacculus supporting part 22 is equipped with far-end branch seal wire
Mouth 223, branch's seal wire 32 can pass through proximal limbs guidewire port 224 and far-end branch guidewire port 223.
As shown in Figure of description 6, before biodegradable stent system pressure is held, sacculus supporting part 22 sequentially passes through bracket fixture portions
12 and stent supporting part 11；And the transitional region between bracket fixture portions 12 and stent supporting part 11 and sacculus supporting part 22 and ball
Transitional region between capsule fixed part 21 fits.
As shown in Figure of description 7, when pressure is held, stent supporting part 11, bracket fixture portions 12, sacculus fixed part 21 and ball
Capsule supporting part 22 is held by radial direction pressure.When pressure is held, radially-inwardly displacement is applied to biodegradable stent system, to special-shaped sacculus 2
Vacuumize negative pressure, it is ensured that less system outline diameter.
Reference explanation book attached drawing 5 (b) and attached drawing 8 are understood, when conveying biodegradable stent system, leading silk 31 and branch lead
Silk 32 is transported in the major blood vessel 41 and branch vessel 42 of target respectively.Wherein, dominate silk 31 and branch's seal wire 32 be motionless,
Distally main guidewire port 213 is main 31 entrance of seal wire, and far-end branch guidewire port 223 is 32 entrance of branch's seal wire, is pushed forward degradable branch
Frame transport system, the main guidewire port 214 of near-end export for main seal wire 31, and proximal limbs guidewire port 224 exports for branch's seal wire 32.When
When conveying is completed, it is ensured that stent supporting part 11 and sacculus supporting part 22 are located in the branch vessel 42 of target, bracket fixture portions 12
At least a portion and sacculus fixed part 21 be located in the major blood vessel 41 of target.
Refer to the attached drawing 9, in biodegradable stent system, during release, pressurising expansion, degradable branch are carried out to special-shaped sacculus 2
Frame 1 is expanded and supports blood vessel, and wherein stent supporting part 11 is close to branch vessel 42, and bracket fixture portions 12 are subject to sacculus fixed part
21 dilating effect, it is in cylinder planar that plastic deformation, which occurs, and grappling is simultaneously close in major blood vessel 41.
After the completion of release, first recall special-shaped sacculus 2, after recall leading silk 31 and branch's seal wire 32, biodegradable stent 1
Lesion vessels are propped up, keep blood flow unobstructed.After the completion of new intima, gradually degraded disappears biodegradable stent 1 in human body,
Blood vessel recovers original anatomic morphological, realizes the function that diastole is shunk under pulse pressure again.
To sum up, provided by the present invention in the biodegradable stent system of bifurcated vessels lesion, biodegradable stent system
System includes：Biodegradable stent 1 and special-shaped sacculus 2, biodegradable stent 1 include stent supporting part 11 and bracket fixture portions 12, all
Bracket fixture portions 12 are connected with stent supporting part 11, and special-shaped sacculus 2 includes sacculus fixed part 21 and sacculus supporting part 22, and ball
Capsule fixed part 21 is connected with sacculus supporting part 22, and whole biodegradable stents 1 and special-shaped sacculus 2 are held by radial direction pressure and be combined.This
The technical solution of application is designed by the structure to biodegradable stent system and application method, using special-shaped sacculus 2 to degradable
Stent 1 is expanded, it is ensured that lesion region can be completely covered in stent supporting part 11 and bracket fixture portions 12；21 meeting of sacculus fixed part
It is in cylinder planar to cause bracket fixture portions 12 that plastic deformation occurs at the same time, is adjacent to major blood vessel, avoids to major blood vessel blood flow
Obstruction；12 deformed stereochemical structure of bracket fixture portions plays the role of grappling, and avoiding can under the impact of long-term blood flow
The migration of degraded stent 1.
It should be noted that in the present specification, such as first and second etc relational terms are used merely to one
Entity is distinguished with other several entities, and without necessarily requiring or implying between these entities, there are any this actual
Relation or order.
The biodegradable stent system provided by the present invention for crotch branch vessel is described in detail above.
Specific case used herein is set forth the principle of the present invention and embodiment, and the explanation of above example is simply used
Understand the method and its core concept of the present invention in help.It should be pointed out that for those skilled in the art,
Without departing from the principle of the present invention, some improvement and modification can also be carried out to the present invention, these are improved and modification
Fall into the protection domain of the claims in the present invention.
Claims (10)
1. a kind of biodegradable stent system for crotch branch vessel, including biodegradable stent (1) and special-shaped sacculus (2),
It is characterized in that,
The biodegradable stent (1) includes：
Along branch vessel (42) extension, being positioned over the stent supporting part (11) in branch vessel (42)；
Positioned at the bottom of the stent supporting part (11), being anchored to the junction of major blood vessel (41) and branch vessel (42)
Bracket fixture portions (12)；
The abnormity sacculus (2) includes：
Along major blood vessel (41) extension, the sacculus fixed part (21) of major blood vessel (41) can be closely attached on；
It is connected with the sacculus fixed part (21) and the sacculus supporting part (22) on the inside of the stent supporting part (11)；Institute
Stating sacculus supporting part (22) can support the stent supporting part (11) to extend out, to realize that the stent supporting part (11) is adjacent to point
Branch vessel (42).
2. the biodegradable stent system according to claim 1 for crotch branch vessel, it is characterised in that the branch
Frame fixed part (12) is specially multiple grappling pawls for being uniformly distributed in stent supporting part (11) bottom.
3. the biodegradable stent system according to claim 2 for crotch branch vessel, it is characterised in that the branch
Frame supporting part (11) is specially the cylindricality reticulate body with open loop hole or closed loop hole.
4. the biodegradable stent system according to claim 2 for crotch branch vessel, it is characterised in that the anchor
Pawl is determined specifically in straight rod-shaped, bending rod, triangle or diamond shape.
5. the biodegradable stent system according to claim 1 for crotch branch vessel, it is characterised in that the ball
Capsule supporting part (22) is arranged on near-end, stage casing or the distal end of the sacculus fixed part (21).
6. the biodegradable stent system according to claim 5 for crotch branch vessel, it is characterised in that the ball
The near-end of capsule fixed part (21) has with the main guidewire port of near-end (214) and distal end passed through for leading silk (31) respectively with distal end
Main guidewire port (213)；The distal end of the near-end of the sacculus fixed part (21) and the sacculus supporting part (22) have respectively to
The proximal limbs guidewire port (224) and far-end branch guidewire port (223) passed through for branch's seal wire (32).
7. the biodegradable stent system for crotch branch vessel according to claim 1~6 any one, its feature
It is, before pressure is held, the sacculus supporting part (22) sequentially passes through the bracket fixture portions (12) and the stent supporting part
(11)；And the transitional region between the bracket fixture portions (12) and the stent supporting part (11) and the sacculus supporting part
(22) transitional region between the sacculus fixed part (21) fits.
8. the biodegradable stent system according to claim 7 for crotch branch vessel, it is characterised in that it is described can
Degraded stent (1) is made of PLA or PCL materials, and the abnormity sacculus (2) is made of nylon material.
9. the biodegradable stent system according to claim 8 for crotch branch vessel, it is characterised in that it is described can
Stent (1) degrade as laser cutting, braiding, 3D printing shaping, the abnormity sacculus (2) is blowing, 3D printing shaping.
10. the biodegradable stent system according to claim 9 for crotch branch vessel, it is characterised in that described
Biodegradable stent (1) and the special-shaped sacculus (2) can radially be pressed by one holds.
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| CN201711366229.7A CN107951603A (en) | 2017-12-18 | 2017-12-18 | A kind of biodegradable stent system for crotch branch vessel |
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| CN201711366229.7A CN107951603A (en) | 2017-12-18 | 2017-12-18 | A kind of biodegradable stent system for crotch branch vessel |
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Application publication date: 20180424 |