CN1079402A - Plastic containers that holding blood products is used and application thereof - Google Patents
Plastic containers that holding blood products is used and application thereof Download PDFInfo
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- CN1079402A CN1079402A CN 92104250 CN92104250A CN1079402A CN 1079402 A CN1079402 A CN 1079402A CN 92104250 CN92104250 CN 92104250 CN 92104250 A CN92104250 A CN 92104250A CN 1079402 A CN1079402 A CN 1079402A
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Abstract
The present invention relates to a kind of medical plastic container and uses thereof, it comprises blood taking tube and breather, and described container and pipeline material are polyolefin or fluoroplastics.Described container can be used in the irradiation and ultraviolet radiation and oxygenation blood recovery therapy of blood products, and is simple to operate, non-toxic and safe, and ultraviolet light is functional thoroughly, uses the danger of no blood cross infection clinically.
Description
The present invention relates to good and the medical plastic container that can oxygenation of a kind of ultraviolet passing performance; The present invention also relates to the application of such plastic containers in blood products irradiation and clinical treatment.
The actinic effect of ultraviolet radiation and oxygenation blood recovery therapy (Ultraviolet Blood Irradiation is called for short UBI) has sterilization, and immune function is adjusted in detoxifcation, improves effects such as hemorheology and promotion energy exchange.This therapy can be used for treating multiple diseases such as severe pulmonary infection, immune disease, cerebrovascular and nervous system disease, and its curative effect is comparatively remarkable, so its clinical practice was increasingly extensive in recent years.Generally adopt quartz container to come splendid attire to blood products clinically at present, commonly used is a kind of quartz container of double-deck hollow, its light transmission is good and can carry out oxygenation to the blood of being contained in it, meet the basic demand of ultraviolet radiation and oxygenation blood recovery therapy to container, but because the price of quartz container too high (800 yuan /), so generally will reuse, because of this can not be as disposable container.So just exist the danger of blood cross-infection, and use troublesome poeration, junction poor sealing performance, in addition, quartz is also damaged easily.Because the above-mentioned existing deficiency of quartz container, so the utmost point needs a kind of safe in utilization, with low cost, light transmission and the good disposable container of oxygenation capacity to substitute quartz container with satisfied needs clinically.
It is good to an object of the present invention is to provide a kind of ultraviolet passing performance, and the energy oxygenation is easy to operate, safe in utilization, the disposable container that cost is low.
Another object of the present invention provides the application of such container in medical field.
The objective of the invention is to realize by following design: with polyolefin or fluoroplastics blowing or be injection molded into semi-finished product, form through power frequency or high frequency heat seal, die temperature is 170 ℃ again.The container transparent that processing makes, high resilience can be any flat three-dimensional shape, is preferably half round post or cuboid, and a side of container is provided with blood taking tube and air inlet pipe, and opposite side is provided with escape pipe; Perhaps, described trachea extends into internal tank, and escape pipe is linked to each other with air inlet pipe, is furnished with aperture on the tube wall of the described trachea of internal tank; Perhaps, below the opening part of the air inlet pipe under container one flat horizontal surface or opening, be provided with a thin film that is furnished with aperture.
The material of described chamber wall, trachea, blood taking tube or thin film all is to be selected from polyolefin or fluoroplastics; The thickness of chamber wall and thin film can be any thickness known to the routine techniques, and thickness range is 30～40 preferably.
Blood sample enters plastic containers through blood taking tube, through the air inlet pipe aerating oxygen; To container irradiation 10～20 minutes, the ultraviolet light wavelength was 260～320nm, is preferably in 280～300nm scope with ultraviolet light.The speed of logical oxygen is 5 liters/minute.
Below with reference to accompanying drawing the present invention is done further detailed elaboration.
Fig. 1 is a sketch map of the present invention, and wherein 1 is blood taking tube, and 2 is air inlet pipe, and 3 is escape pipe.
Fig. 2 is another sketch map of container of the present invention, and wherein 1 is blood taking tube, and 2 is breather.
Fig. 3 is another sketch map of container of the present invention, and wherein 1 for advancing blood vessel, and 4 for going out blood vessel, and 2 is air inlet pipe, and 3 is escape pipe, and 5 is inner lining film, and 6 is the aperture on the thin film.
Fig. 4 is the curve chart of the ultraviolet passing performance of the relative quartz glass of expression container of the present invention.
Fig. 5 represents container of the present invention and the aerial ultraviolet passing performance chart of quartz container.
Embodiment 1
Get polyolefin blow molding according to a conventional method, through the synthetic container as shown in Figure 1 of high frequency heat, connect blood taking tube 1 on the base of container one side again, on the top margin of homonymy, connect air inlet pipe 2, on the top margin of the relative side of container, connect escape pipe 3.This wall of a container is thick to be 37, and each manages diameter is 5mm, container transparent, high resilience.
Get polyolefin blow molding according to a conventional method, through the synthetic container as shown in Figure 2 of high frequency heat, container one side connects blood taking tube 1 again, and breather 2 extends to outside the relative side from a side of container, and described airway wall is provided with aperture in the internal tank office.This container wall thickness is 34, and the external diameter of blood taking tube 1 and breather is respectively 1cm, prepared container transparent, high resilience.
Get polyolefin blow molding according to a conventional method, in container, be furnished with the thin film 5 of aperture 6 on the trachea opening part lining under the flat horizontal surface, again through the synthetic container as shown in Figure 2 of high frequency heat.Connect escape pipe 3 and air inlet pipe 2 on container one flat horizontal surface, be provided with the inner lining film 5 that is covered with aperture 6 in described air inlet pipe 2 in the opening part of internal tank, escape pipe extends into the below (promptly extending in the space that container relative one flat-sided plane and inner lining film and two sides surround) of inner lining film 5.One side of container connects into blood vessel 1 and goes out blood vessel 4, and this container wall thickness is 40, and the internal diameter of pipeline can be 4mm, and the container that makes like this is transparent, and high resilience.
Comparing embodiment 1
Except adopting PVC to replace polyolefin as the container material, other with embodiment 1 described respectively go on foot identical, thereby make the PVC container.
Comparing embodiment 2
Except selecting PVC for use rather than be used as the container stock with polyolefin, other each step is identical with described in the embodiment 2 all, finally made the PVC container.
Test:
1. light transmission test relatively:
Respectively get prepared four containers in embodiment 1,2, the comparing embodiment 1 and 2, measure under different wave length container transmittance separately with the UV-240 spectrophotometer respectively.As 100% benchmark, calculate the relative transmittance of four containers with the measured transmittance of the quartz container under the equal experimental condition respectively.As transverse axis, transmittance is mapped as the longitudinal axis relatively, obtains the curve of Fig. 4 with the irradiation light wavelength.In the drawings, labelling ● be the measured curve of embodiment 1 container; Labelling ■ is the measured curves of embodiment 2 containers; Zero and be respectively the measured curve of container in comparing embodiment 1 and 2.
2. absolute printing opacity test
Choose prepared container in embodiment 1,2 and 3 respectively, choose quartz glass in addition again, measure separately transmittance respectively by above-mentioned test 1 described method, make transverse axis with the irradiates light wavelength, transmittance is done longitudinal axis mapping, obtains the curve of Fig. 5.In the drawings, labelling △ is the measured curve of quartz glass, ▲ be the measured transmittance curve of container of the present invention.
Shown in Figure 4 and 5, be 320～260nm(ultra-violet (UV) band in wave-length coverage) in, its ultraviolet light transmission of container of the present invention is good, the then saturating hardly ultraviolet light of PVC container.Result of the test shows that its saturating ultraviolet light performance of container of the present invention and quartz glass are more approaching.
3. acute toxicity test:
Do acute toxicity test with white mice, the result shows that polyolefin or fluoroplastics all are that abiology is toxic.
This shows that medical plastic container physicochemical property of the present invention is stable, abiology toxicity, ultraviolet-transmitting is functional, and is easy to process, cheap, is the 2-3% of quartz container only, can be used as disposable container and uses. In clinical practice, this container can be used as the container of irradiated blood platelet, blood product, also can be used for the container in the ultraviolet blood irradiation and oxygenation self-blood feedback therapy, it has easy to operate, the junction good airproof performance, the advantage of cracky is not particularly used as disposable container, then avoid the cross-infection of blood fully, particularly avoided the blood cross-infections such as hepatitis B, the third liver AIDS and syphilis.
Claims (10)
1, a kind of plastic containers is characterized in that it comprises blood taking tube 1, air inlet pipe 2 and escape pipe 3, and described container and pipeline material system is selected from by polyolefin and fluoroplastics and is formed a kind of in the group.
2, plastic containers according to claim 1 is characterized in that described air inlet pipe 2 and escape pipe 3 all extend and link together, and are furnished with aperture on the tracheal wall of internal tank in container.
3, plastic containers according to claim 1, the below that it is characterized in that air inlet pipe opening part under described container one flat horizontal surface or opening are provided with a thin film that is furnished with aperture.
4, the application of a kind of plastic containers in the irradiation of blood goods, this container comprises blood taking tube 1, air inlet pipe 2 and escape pipe 3, described container and pipeline material system is selected from by polyolefin and fluoroplastics and is formed a kind of in the group, it is characterized in that with wave-length coverage be the container that the irradiation under ultraviolet ray of 260～320nm fills blood product.
5, application according to claim 3 is characterized in that described wave-length coverage is 280nm～300nm.
6, according to claim 3 or 4 described application, the irradiation time that it is characterized in that ultraviolet light is 10～20 minutes.
7, the application of a kind of plastic containers in ultraviolet radiation and oxygenation blood recovery therapy, this container comprises blood taking tube 1, air inlet pipe 2 and escape pipe 3, described container and pipeline material system is selected from by polyolefin and fluoroplastics and is formed a kind of in the group, it is characterized in that with wavelength be the described container that the irradiation under ultraviolet ray of 260～320nm fills blood, simultaneously through the air inlet pipe aerating oxygen.
8, application according to claim 6 is characterized in that described ultraviolet wavelength scope is 280～300nm.
9, according to claim 6 and 7 described application, the irradiation time that it is characterized in that ultraviolet light is 10～20 minutes.
10, application according to claim 6 is characterized in that the speed of logical oxygen is 5 liters/minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92104250 CN1048391C (en) | 1992-05-30 | 1992-05-30 | Plastic container for holding blood products and its use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92104250 CN1048391C (en) | 1992-05-30 | 1992-05-30 | Plastic container for holding blood products and its use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1079402A true CN1079402A (en) | 1993-12-15 |
| CN1048391C CN1048391C (en) | 2000-01-19 |
Family
ID=4940709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92104250 Expired - Fee Related CN1048391C (en) | 1992-05-30 | 1992-05-30 | Plastic container for holding blood products and its use |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1048391C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100506184C (en) * | 1996-05-13 | 2009-07-01 | B.布朗医学公司 | Transmission carrier used for sterilization by electron jet irradiation |
| CN100581590C (en) * | 2006-12-08 | 2010-01-20 | 苏州奇天输血技术有限公司 | Manufacturing method of high-temperature-resistant high-light-transmittance photochemical reaction container |
-
1992
- 1992-05-30 CN CN 92104250 patent/CN1048391C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100506184C (en) * | 1996-05-13 | 2009-07-01 | B.布朗医学公司 | Transmission carrier used for sterilization by electron jet irradiation |
| CN100581590C (en) * | 2006-12-08 | 2010-01-20 | 苏州奇天输血技术有限公司 | Manufacturing method of high-temperature-resistant high-light-transmittance photochemical reaction container |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1048391C (en) | 2000-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI BLOOD TRANSFUSION TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SHANGHAI CITY BLOOD CENTER Effective date: 20030516 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20030516 Address after: 200051 No. 1191, Hongqiao Road, Shanghai Patentee after: Shanghai Blood-Transfusion Technology Co., Ltd. Address before: No. 479, Lane 10, Shanghai, Nanjing West Road Patentee before: Shanghai Blood Center |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |