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CN107937156A - High-efficiency multi-enzyme cleaning agent for medical equipment and preparation method thereof - Google Patents

High-efficiency multi-enzyme cleaning agent for medical equipment and preparation method thereof Download PDF

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Publication number
CN107937156A
CN107937156A CN201711421499.3A CN201711421499A CN107937156A CN 107937156 A CN107937156 A CN 107937156A CN 201711421499 A CN201711421499 A CN 201711421499A CN 107937156 A CN107937156 A CN 107937156A
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Prior art keywords
cleaning
lysozyme
amylase
protease
cellulase
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CN201711421499.3A
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Chinese (zh)
Inventor
杨同勇
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Dalian Sandaaoke Chemistry Co Ltd
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Dalian Sandaaoke Chemistry Co Ltd
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Priority to CN201711421499.3A priority Critical patent/CN107937156A/en
Publication of CN107937156A publication Critical patent/CN107937156A/en
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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • C11D3/04Water-soluble compounds
    • C11D3/046Salts
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2041Dihydric alcohols
    • C11D3/2044Dihydric alcohols linear
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2075Carboxylic acids-salts thereof
    • C11D3/2086Hydroxy carboxylic acids-salts thereof
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38663Stabilised liquid enzyme compositions

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Detergent Compositions (AREA)

Abstract

The invention discloses a medical instrument high-efficiency multienzyme cleaning agent capable of improving cleaning quality and efficiency, which comprises the following raw materials in percentage by mass: 0.5-5% of isomeric tridecanol ether oxide, 5-10% of propylene glycol, 1-20% of potassium lactate, 2% of biological enzyme, 0.1-5% of cleaning assistant and the balance of deionized water; the biological enzyme is a mixture of protease, lipase, cellulase, amylase and lysozyme; the cleaning auxiliary agent is ferric chloride, sodium chlorate or potassium permanganate. The preparation method comprises the following steps: a. dissolving isomeric tridecanol ether oxide, propylene glycol, potassium lactate and a cleaning auxiliary agent in deionized water, uniformly stirring, and cooling for later use; b. and (c) adding lipase, cellulase, amylase, lysozyme and protease into the liquid prepared in the step (a) in sequence, and stirring uniformly.

Description

医疗器械高效多酶清洗剂及其制备方法High-efficiency multi-enzyme cleaning agent for medical equipment and preparation method thereof

技术领域technical field

本发明属于专用清洗剂技术领域,尤其涉及一种可提高清洗质量和效率的医疗器械高效多酶清洗剂及制备方法。The invention belongs to the technical field of special cleaning agents, and in particular relates to a high-efficiency multi-enzyme cleaning agent for medical instruments that can improve cleaning quality and efficiency and a preparation method.

背景技术Background technique

医院里多种手术和人体检查工具是重复使用的器械,此类器械在使用后,其表面会沾染血迹、油脂、组织液和体液等有机污染物,传统的化学清洗剂并不能彻底将其清洗干净。由于所残留的有机污染物组分复杂,因此可在器械表面累计覆盖生物膜,将导致严重的污染腐蚀或病菌滋生,不仅降低器械的使用寿命,而且会给人们的身体健康带来威胁。目前人们已经发现,某些生物酶能够与特定有机物发生反应,从而将污染物分解掉,故已有多种生物酶清洗剂,各清洗剂根据污染物的种类,选择蛋白酶、纤维素酶、脂肪酶、淀粉酶和溶菌酶等生物酶中的一种或多种。然而,医疗行业实际操作中,难以保证对使用后的器械及时清洗,长久搁置致使有机物干涸粘附在器械上,即使用现有的生物酶清洗剂也难以清洗,不仅耗时费力,而且还不能保证有机污染物被彻底清洗,安全隐患极大。A variety of surgical and human examination tools in the hospital are reusable instruments. After use, the surface of such instruments will be contaminated with organic pollutants such as blood, grease, tissue fluid, and body fluids. Traditional chemical cleaning agents cannot completely clean them. . Due to the complex components of the residual organic pollutants, biofilms can be accumulated on the surface of the device, which will lead to serious pollution and corrosion or the growth of bacteria, which will not only reduce the service life of the device, but also pose a threat to people's health. At present, it has been found that some biological enzymes can react with specific organic substances, thereby decomposing pollutants, so there are many kinds of biological enzyme cleaning agents, and each cleaning agent chooses protease, cellulase, fat One or more of biological enzymes such as enzyme, amylase and lysozyme. However, in the actual operation of the medical industry, it is difficult to ensure timely cleaning of the used instruments. Long-term storage causes organic matter to dry up and adhere to the instruments. Even with existing biological enzyme cleaning agents, it is difficult to clean. To ensure that organic pollutants are thoroughly cleaned, there are great potential safety hazards.

发明内容Contents of the invention

本发明是为了解决现有技术所存在的上述技术问题,提供一种可提高清洗质量和效率的医疗器械高效多酶清洗剂及制备方法。The present invention aims to solve the above-mentioned technical problems existing in the prior art, and provides a high-efficiency multi-enzyme cleaning agent for medical instruments and a preparation method that can improve cleaning quality and efficiency.

本发明的技术解决方案是:一种医疗器械高效多酶清洗剂,其特征在于所用原料及质量百分比如下:异构十三醇醚氧化物0.5~5%,丙二醇5~10%,乳酸钾1~20%,生物酶2%,清洗助剂0.1~5%、去离子水余量;所述生物酶为蛋白酶、脂肪酶、纤维素酶、淀粉酶和溶菌酶的混合物;所述清洗助剂为氯化铁、氯酸钠或高锰酸钾。The technical solution of the present invention is: a high-efficiency multi-enzyme cleaning agent for medical equipment, which is characterized in that the raw materials used and the mass percentage are as follows: isomeric tridecyl alcohol ether oxide 0.5-5%, propylene glycol 5-10%, potassium lactate 1 ~20%, biological enzyme 2%, cleaning aid 0.1~5%, the balance of deionized water; the biological enzyme is a mixture of protease, lipase, cellulase, amylase and lysozyme; the cleaning aid For ferric chloride, sodium chlorate or potassium permanganate.

一种上述医疗器械高效多酶清洗剂的制备方法,按照以下步骤进行:A preparation method of the above-mentioned high-efficiency multi-enzyme cleaning agent for medical instruments is carried out according to the following steps:

a. 将异构十三醇醚氧化物、丙二醇、乳酸钾和清洗助剂溶解于去离子水中,搅拌均匀,冷却待用;a. Dissolve isotridecyl alcohol ether oxide, propylene glycol, potassium lactate and cleaning aid in deionized water, stir evenly, and cool for later use;

b. 将脂肪酶、纤维素酶、淀粉酶、溶菌酶和蛋白酶,依次添加到a步骤所制备的液体中,搅拌均匀即可。b. Add lipase, cellulase, amylase, lysozyme and protease to the liquid prepared in step a in sequence, and stir evenly.

本发明原料来源广泛,制备方法简单。各组分相互作用,相比于现有医用多酶清洗剂,本发明的优点在于:更易于吸附于器械表面,从而起到“楔子”的作用,使有机污染物,甚至干涸的有机物从器械表面剥离;可氧化有机污染物,使大分子量的有机物变性或断裂成小分子量有机物,利于生物酶对有机物的分解,可提高清洗质量和效率。The invention has wide source of raw materials and simple preparation method. The components interact with each other. Compared with the existing medical multi-enzyme cleaning agent, the present invention has the advantage that it is easier to adsorb on the surface of the device, thereby acting as a "wedge", so that organic pollutants, even dried organic matter, are removed from the device. Surface peeling; it can oxidize organic pollutants, denature or break large molecular weight organic matter into small molecular weight organic matter, which is beneficial to the decomposition of organic matter by biological enzymes, and can improve cleaning quality and efficiency.

具体实施方式Detailed ways

实施例1:Example 1:

所用原料及质量百分比如下:异构十三醇醚氧化物0.5%、丙二醇10%、乳酸钾20%、蛋白酶0.5%、脂肪酶0.5%、纤维素酶0.3%、淀粉酶0.4%、溶菌酶0.3%、高锰酸钾0.1%和去离子水余量配制而成。The raw materials and mass percentages used are as follows: isotridecyl alcohol ether oxide 0.5%, propylene glycol 10%, potassium lactate 20%, protease 0.5%, lipase 0.5%, cellulase 0.3%, amylase 0.4%, lysozyme 0.3% %, 0.1% potassium permanganate and the balance of deionized water.

制备方法如下:将计算量的异构十三醇醚氧化物、丙二醇、乳酸钾和高锰酸钾溶解于去离子水中,搅拌速度为200转/分钟搅拌15分钟;再依次添加脂肪酶、纤维素酶、淀粉酶、溶菌酶和蛋白酶,搅拌速度为50转/分钟搅拌15分钟即可。The preparation method is as follows: Dissolve the calculated amount of isotridecyl alcohol ether oxide, propylene glycol, potassium lactate and potassium permanganate in deionized water, stir at a stirring speed of 200 rpm for 15 minutes; then add lipase, fiber Vegetase, amylase, lysozyme and protease, the stirring speed is 50 rpm and stirred for 15 minutes.

实施例2:Example 2:

所用原料及质量百分比如下:异构十三醇醚氧化物5%,丙二醇5%,乳酸钾1%,蛋白酶0.5%、脂肪酶0.5%、纤维素酶0.4%、淀粉酶0.2%、溶菌酶0.4%、氯化铁5%和去离子水余量配制而成。The raw materials and mass percentages used are as follows: isotridecyl alcohol ether oxide 5%, propylene glycol 5%, potassium lactate 1%, protease 0.5%, lipase 0.5%, cellulase 0.4%, amylase 0.2%, lysozyme 0.4% %, 5% ferric chloride and the balance of deionized water.

生产方法同实施例1。Production method is with embodiment 1.

实施例3:Example 3:

异构十三醇醚氧化物3%、丙二醇7%、乳酸钾10%、蛋白酶0.5%、脂肪酶0.4%、纤维素酶0.5%、淀粉酶0.3%、溶菌酶0.3%、氯酸钠3%和去离子水余量配制而成。Isogenic tridecyl alcohol ether oxide 3%, propylene glycol 7%, potassium lactate 10%, protease 0.5%, lipase 0.4%, cellulase 0.5%, amylase 0.3%, lysozyme 0.3%, sodium chlorate 3% It is prepared with the balance of deionized water.

生产方法同实施例1。Production method is with embodiment 1.

将本发明实施例1、实施例2或实施例3原液,加水稀释至质量浓度0.3%~1%,按照浸泡超声或刷洗方法清洗,可一次性去除有机污染物,之后用清水漂洗,烘干即可。Dilute the stock solution of Example 1, Example 2 or Example 3 of the present invention with water to a mass concentration of 0.3% to 1%, and clean it by soaking ultrasonic or brushing to remove organic pollutants at one time, then rinse with water, and dry That's it.

Claims (2)

1.一种医疗器械高效多酶清洗剂,其特征在于所用原料及质量百分比如下:异构十三醇醚氧化物0.5~5%,丙二醇5~10%,乳酸钾1~20%,生物酶2%,清洗助剂0.1~5%、去离子水余量;所述生物酶为蛋白酶、脂肪酶、纤维素酶、淀粉酶和溶菌酶的混合物;所述清洗助剂为氯化铁、氯酸钠或高锰酸钾。1. A high-efficiency multi-enzyme cleaning agent for medical instruments, characterized in that the raw materials used and their mass percentages are as follows: 0.5-5% isomeric tridecyl alcohol ether oxide, 5-10% propylene glycol, 1-20% potassium lactate, biological enzyme 2%, cleaning aid 0.1~5%, the balance of deionized water; the biological enzyme is a mixture of protease, lipase, cellulase, amylase and lysozyme; the cleaning aid is ferric chloride, chlorine Sodium Oxide or Potassium Permanganate. 2.一种如权利要求1所述医疗器械高效多酶清洗剂的制备方法,其特征在于按照以下步骤进行:2. a kind of preparation method of high-efficiency multi-enzyme cleaning agent for medical instruments as claimed in claim 1, is characterized in that carrying out according to the following steps: a. 将异构十三醇醚氧化物、丙二醇、乳酸钾和清洗助剂溶解于去离子水中,搅拌均匀,冷却待用;a. Dissolve isotridecyl alcohol ether oxide, propylene glycol, potassium lactate and cleaning aid in deionized water, stir evenly, and cool for later use; b. 将脂肪酶、纤维素酶、淀粉酶、溶菌酶和蛋白酶,依次添加到a步骤所制备的液体中,搅拌均匀即可。b. Add lipase, cellulase, amylase, lysozyme and protease to the liquid prepared in step a in sequence, and stir evenly.
CN201711421499.3A 2017-12-25 2017-12-25 High-efficiency multi-enzyme cleaning agent for medical equipment and preparation method thereof Pending CN107937156A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020058226A1 (en) * 2018-09-17 2020-03-26 Dsm Ip Assets B.V. Animal feed compositions and uses thereof
CN115197788A (en) * 2022-08-18 2022-10-18 北京佳士力科技有限公司 Special cleaning agent for oral cavity instruments and preparation method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103865663A (en) * 2012-12-12 2014-06-18 深圳市绿微康生物工程有限公司 Medical multi-enzyme cleaning agent and preparation method thereof
CN104073367A (en) * 2013-12-05 2014-10-01 成都老肯科技股份有限公司 Multienzyme cleaning solution suitable for machine-washable medical devices and preparation method thereof
CN105154253A (en) * 2015-10-09 2015-12-16 湖北穆兰同大科技有限公司 Biological multienzyme cleaning agent and preparation method thereof
CN106318687A (en) * 2016-08-19 2017-01-11 南京巨鲨显示科技有限公司 Medical multienzyme washing bag
CN106893647A (en) * 2017-02-28 2017-06-27 长安大学 A kind of multienzyme medicine equipment cleaning agent and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103865663A (en) * 2012-12-12 2014-06-18 深圳市绿微康生物工程有限公司 Medical multi-enzyme cleaning agent and preparation method thereof
CN104073367A (en) * 2013-12-05 2014-10-01 成都老肯科技股份有限公司 Multienzyme cleaning solution suitable for machine-washable medical devices and preparation method thereof
CN105154253A (en) * 2015-10-09 2015-12-16 湖北穆兰同大科技有限公司 Biological multienzyme cleaning agent and preparation method thereof
CN106318687A (en) * 2016-08-19 2017-01-11 南京巨鲨显示科技有限公司 Medical multienzyme washing bag
CN106893647A (en) * 2017-02-28 2017-06-27 长安大学 A kind of multienzyme medicine equipment cleaning agent and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020058226A1 (en) * 2018-09-17 2020-03-26 Dsm Ip Assets B.V. Animal feed compositions and uses thereof
CN115197788A (en) * 2022-08-18 2022-10-18 北京佳士力科技有限公司 Special cleaning agent for oral cavity instruments and preparation method

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Application publication date: 20180420