CN107929387A - A kind of preparation for treating rhinitis chronic - Google Patents
A kind of preparation for treating rhinitis chronic Download PDFInfo
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- CN107929387A CN107929387A CN201711116724.2A CN201711116724A CN107929387A CN 107929387 A CN107929387 A CN 107929387A CN 201711116724 A CN201711116724 A CN 201711116724A CN 107929387 A CN107929387 A CN 107929387A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of preparation for treating rhinitis chronic, is to take the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae, honeysuckle, campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae, medicinal powder is made, then add auxiliary material and various pharmaceutical preparations are made to obtain the final product.A kind of preparation for treating rhinitis chronic provided by the invention, the cure rate of said preparation treatment rhinitis is high, and therapeutic effect is good, quick.The flower bud of lily magnolia and the achene of Siberian cocklebur are selected in invention formulation, and as monarch drug in a prescription, radix stellariae dichotomae, honeysuckle are ministerial drug, are aided with adjutant and make medicine, each efficacy of drugs synergistic effect, are controlled in outer disease, gained preparation is treated both principal and secondary aspect of disease, and improves curative effect.The preparation pin of the present invention can rhinitis chronic treated, therapeutic effect is good, and cure rate is high, and recurrence rate is low.Invention formulation thing is without side-effects, safe.The cost of invention formulation is low, alleviates medical expense.Formulation preparation method provided by the invention is easy to operate, and condition is easy to control.
Description
Technical field
The present invention relates to a kind of preparation for treating rhinitis chronic, technical field of traditional Chinese medicines is particularly belonged to.
Background technology
Rhinitis, that is, nasal cavity inflammatory disease, is virus, bacterium, allergen, various physical and chemical factors and some systemic diseases
The inflammation of caused bronchia mucosal.It is several that rhinitis can be divided into acute, chronic, atrophic, allergy etc..Patients with rhinitis often can
There are the symptoms such as nasal obstruction, stream clear water tears, rhiocnesmus, the uncomfortable, cough of throat, or even brain is not regained consciousness.The main pathological change of rhinitis
It is bronchia mucosal hyperemia, swelling, exudation, hyperplasia, atrophy or necrosis etc..Rhinitis chronic is the chronic inflammation of schneiderian membrance and submucosa
Disease.It is mainly characterized by inflammation and continues more than three months or recurrent exerbation, protracted course of disease, and the intermittent phase cannot also recover normal, and
Without clear and definite pathogenic microorganisms, with different degrees of nasal obstruction, secretion increases, and schneiderian membrance swelling or the obstacle such as thickens.At present
The method for the treatment of rhinitis mainly uses：(1) intranasal to use glucocorticoid, (2) nasal cavity cleaning, (3) are intranasal to use decongestant, (4)
Including other treatments such as block therapy, acupuncture therapies.The traditional Chinese medical science thinks that lungs imbalance is the main pathogenesis for causing rhinopathy.Such as Lung Qi deficiency
Then table is defended not solid, and the susceptible exopathogen of nose key is disease；Or lung, by heresy, a surname sends out unfavorable, then nose gas is unfavorable, then has a stuffy nose obstructed；Or lung loses Is-dated
Drop, then the turbid tears delay of cult poison, produces a variety of rhinopathys, and along with catching cold, perverse trend is attacked nose key and caused.This often touching difficulty of disease
More, first it is weakened body resistance and evil love, is second that exopathogen is objective long, changes the bright Tianjin of fire and the turbid obstruction nose key of phlegm.《Yan's prescriptions for succouring sick》Say：" husband
Nose person, it is disease for the time ... of lung, to be defeated in battle, be carbuncle, be polyp, be sore, being clear nasal discharge, for stop up it is obstructed, be turbid tears or not
Hear good and foul smells, all lungs are uncomfortable, perverse trend is pented up in nose for this, clean the street be jammed and so ".And with spleen, kidney to lung shadow in the vital organs of the human body
Maximum, spleen pertaining to the earth is rung, for the mother of lung, the source of studentsization of the insufficiency of the spleen then lung deficiency syndrome of the lung absolutely；Kidney category water, Jinsui River alternate, and lung are received gas and are attributed to
Kidney, the two interacts.In the prior art, the preparation of rhinitis chronic is treated also there are therapeutic effect deficiency, treatment cycle is grown etc.
Problem.To solve the above-mentioned problems, a kind of preparation of new treatment rhinitis chronic is studied, it appears particularly necessary.
The content of the invention
To solve the deficiencies in the prior art, it is an object of the invention to provide a kind of preparation for treating rhinitis chronic, treatment
Effect is good, and cure rate is high.
In order to realize above-mentioned target, the present invention adopts the following technical scheme that：
A kind of preparation for treating rhinitis chronic, takes the flower bud of lily magnolia, achene of Siberian cocklebur, radix stellariae dichotomae, honeysuckle, campanulaceae, Fructus Forsythiae, peppermint, anti-
Wind, dark plum, Schisandra chinensis and radix glycyrrhizae, are made medicinal powder, then add auxiliary material and various pharmaceutical preparations are made to obtain the final product.
In the preparation of aforementioned therapies rhinitis chronic, be made one of medicinal powder mode be take respectively the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae,
Honeysuckle, campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae, cleaning, after drying, are ground into medicinal powder.
In the preparation of aforementioned therapies rhinitis chronic, medicinal powder is through the following steps that be made：By the measurement flower bud of lily magnolia, the achene of Siberian cocklebur, silver
Radix bupleuri and honeysuckle, add ethanol, refluxing extraction, filtering, obtains alcohol extract, spare；By measuring campanulaceae, Fructus Forsythiae, peppermint, windproof, black
Plum, Schisandra chinensis and radix glycyrrhizae, add water, decoct extraction, filtering, be concentrated under reduced pressure to obtain Aqueous extracts, then adds ethanol, stirs evenly, quiet
Put, take upper liquid, it is spare；Alcohol extract and upper liquid are mixed, are concentrated under reduced pressure to give concentrate, concentrate is dried to obtain medicinal extract and carries
Thing is taken, is pulverized and sieved, obtains medicinal powder.
Further, in the preparation of aforementioned therapies rhinitis chronic, medicinal powder is through the following steps that be made：By measure the flower bud of lily magnolia,
The achene of Siberian cocklebur, radix stellariae dichotomae and honeysuckle, add 6~8 times of 60%~80% ethanol of amount, refluxing extraction 2~4 times, each 1h~2h, mistake
Filter, obtains alcohol extract, spare；By campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae is measured, add the water of 8~10 times of amounts,
Extraction 1~3 time, each 1h~2h is decocted, filtering, is concentrated under reduced pressure, obtains Aqueous extracts, then add ethanol, stir evenly, control material
Concentration of alcohol stands 8h, takes upper liquid 70% in liquid, spare；Alcohol extract and upper liquid are mixed, are concentrated under reduced pressure into obtain close
The concentrate for 1.05 is spent, concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and obtains medicinal powder.
Preferably, in the preparation of aforementioned therapies rhinitis chronic, medicinal powder is through the following steps that be made：By measuring the flower bud of lily magnolia, grey
The ears or side handles of a utensil, radix stellariae dichotomae and honeysuckle, add 7 times of 70% ethanol of amount, refluxing extraction 3 times, each 1.5h, filtering, obtains alcohol extract, spare；
By campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae is measured, add the water of 9 times of amounts, decoct extraction 2 times, each 1.5h,
Filtering, is concentrated under reduced pressure, obtains Aqueous extracts, then add ethanol, stir evenly, and controls concentration of alcohol in feed liquid 70%, to stand 8h,
Upper liquid is taken, it is spare；Alcohol extract and upper liquid are mixed, are concentrated under reduced pressure into obtain the concentrate that density is 1.05, concentrate is done
It is dry to obtain medicinal extract extract, pulverize and sieve, obtain medicinal powder.
In the preparation of aforementioned therapies rhinitis chronic, in parts by weight, 10~30 parts of the flower bud of lily magnolia, the achene of Siberian cocklebur 10~25 are taken
Part, 5~15 parts of radix stellariae dichotomae, 10~25 parts of honeysuckle, 5~15 parts of campanulaceae, 7~18 parts of Fructus Forsythiae, 6~20 parts of peppermint, windproof 5~15
3~12 parts of part, 4~12 parts of dark plum, 3~16 parts of Schisandra chinensis and radix glycyrrhizae.
Further, in the preparation of aforementioned therapies rhinitis chronic, in parts by weight, 15~30 parts of the flower bud of lily magnolia, Siberian cocklebur are taken
Son 10~20 parts, 5~12 parts of radix stellariae dichotomae, 10~20 parts of honeysuckle, 8~15 parts of campanulaceae, 8~18 parts of Fructus Forsythiae, 6~15 parts of peppermint,
3~10 parts of windproof 5~12 parts, 4~10 parts of dark plum, 3~13 parts of Schisandra chinensis and radix glycyrrhizae.
Preferably, in the preparation of aforementioned therapies rhinitis chronic, in parts by weight, take 20 parts of the flower bud of lily magnolia, 15 parts of the achene of Siberian cocklebur,
10 parts of radix stellariae dichotomae, 15 parts of honeysuckle, 10 parts of campanulaceae, 10 parts of Fructus Forsythiae, 10 parts of peppermint, 8 parts windproof, 8 parts of dark plum, 8 parts of Schisandra chinensis and
6 parts of radix glycyrrhizae.
In the preparation of aforementioned therapies rhinitis chronic, pharmaceutical preparation is powder, decoction, granule, tablet, capsule, oral
Liquid, the water-bindered pill or dripping pill.
In the preparation of aforementioned therapies rhinitis chronic, pharmaceutical preparation is prepared one of in the following ways：
1. powder of getting it filled, adds starch as adhesive, adds water stirring, be put into after being pressed into bar in plodder, then use pill
Mechanism pelletization, up to the water-bindered pill；
2. taking millet or the hawthorn of a diameter of 0.9~1mm, medicinal powder is sprayed, it is round as a ball, screen, shaping, adds complementary component
Capping, to obtain the final product；
3. powder of getting it filled is directly loadable into capsule up to capsule.
Select kinds of traditional Chinese medicines material as follows as bulk pharmaceutical chemicals, the effect of its pharmacological property in the present invention：
The flower bud of lily magnolia：It is warm-natured, acrid flavour.Distributed in lung channel, stomach.Dispersing wind and cold, clearing the nasal passage.Belong to the relieving the exterior syndrome with drugs pungent in flavor and warm in property of diaphoretic medicine subordinate classification
Medicine.
The achene of Siberian cocklebur：It is warm-natured, acrid flavour, hardship.It is distributed in lung channel.With relieve heat is wet, clearing the nasal passage, insecticidal action.Belong to and classifying under diaphoretic medicine
Warm-pungent diaphoretic drug.
Radix stellariae dichotomae：Cold nature, it is sweet in flavor.Return liver warp, stomach.Effect：Clearind deficient heat, treating infantile malnutrition wide fever.Belong to astringent medicinal subordinate classification
Lung-intestine astringent medicinal.
Honeysuckle：It is cold in nature, it is sweet in flavor.Distributed in lung channel, the heart channel of Hang-Shaoyin, stomach.There is clearing heat and detoxicating, wind-heat dissipating.Belong to heat-clearing
The heat-clearing and detoxifying drug of medicine subordinate classification.
Campanulaceae：It is mild-natured, it is bitter, pungent.It is distributed in lung channel.Clearing lung and eliminating the phlegm, relieving sore throat and evacuating pus.Classify under category expectorants, antitussives and anti-asthmatics medicine clear
Change hot phlegm medicine.
Fructus Forsythiae：Cold nature, bitter.Distributed in lung channel, the heart channel of Hang-Shaoyin, small intestinl channel.Clearing heat and detoxicating, dispersing swelling and dissipating binds.Belong to antipyretic subordinate point
The heat-clearing and detoxifying drug of class.
Peppermint：It is cool in nature, acrid flavour.Distributed in lung channel, Liver Channel.Effect：Dispelling wind-heat, refresh oneself, promoting eruption.Belong to diaphoretic medicine subordinate classification
Cold-pungent and diaphoretic drugs.
It is windproof：It is warm-natured, it is sweet in flavor, pungent.Return bladder warp, Liver Channel, the spleen channel.Effect：Deliver, wind-dispelling, dehumidifying.Belong to lower point of diaphoretic medicine
Class warm-pungent diaphoretic drug.
Dark plum：It is mild-natured, it is sour, puckery.Return liver warp, the spleen channel, lung channel, large intestine channel.Astringe the lung, puckery intestines, promote the production of body fluid, claming ascaris.Belong to inducing astrigency
Lung-intestine astringent medicinal under medicine classification.
Schisandra chinensis：It is warm-natured, it is sour, sweet.Distributed in lung channel, the heart channel of Hang-Shaoyin, kidney channel.Effect：Restrain astringent method, nourishing generate fluid, kidney calming.
Belong to the lung-intestine astringent medicinal under astringent medicinal classification.
Radix glycyrrhizae：It is mild-natured, it is sweet in flavor.Thoughts of returning home warp, stomach, the spleen channel, lung channel.Invigorate the spleen and benefit qi, cough-relieving apophlegmatic, emergency analgesic therapy, reconcile
Pharmacological property.Belong to the Qi-tonifying drug classified under qi-restoratives medicine.
Flower bud of lily magnolia dispersing wind and cold, clearing the nasal passage in we；The achene of Siberian cocklebur is warm-natured, and relieve heat is wet, clearing the nasal passage；Both are monarch drug in a prescription altogether.Radix stellariae dichotomae
Clearind deficient heat, treating infantile malnutrition wide fever；Honeysuckle is cold in nature, clearing heat and detoxicating, wind-heat dissipating；Both are ministerial drug altogether.Campanulaceae clearing lung and eliminating the phlegm, relieving sore-throat row
Purulence；Fructus Forsythiae is clearing heat and detoxicating, dispersing swelling and dissipating binds, is adjutant.Peppermint, windproof, dark plum, Schisandra chinensis, radix glycyrrhizae dispelling wind-heat, refresh oneself, hair
Table, wind-dispelling, dehumidify, invigorate the spleen and benefit qi, cough-relieving apophlegmatic, emergency analgesic therapy, mediation property of medicine, to make medicine.All medicines share, is disappeared with playing relieve heat
Inflammation, declares the work(of clearing the nasal passage.
Science in order to ensure the present invention program, effectively and reasonably, inventor has carried out a series of confirmatory experiment.
1st, alcohol extraction process screens
The factor for influencing alcohol extracting mainly has the following aspects：Concentration of alcohol, alcohol adding amount, return time, extraction time etc..
This experiment makees the experiment of four factors, three horizontal quadrature, screening with four alcohol adding amount, concentration of alcohol, return time, extraction time factors
Alcohol extraction process condition, factor level table are shown in Table 1.
1 alcohol extracting quadrature factor water-glass of table
1. index selects
Carry out preferred alcohol extracting condition using the extracted amount of Chlorogenic Acid of Flos Lonicerae as evaluation index.
2. sample preparation
Medicinal material flower bud of lily magnolia 20g, achene of Siberian cocklebur 15g, radix stellariae dichotomae 10g and honeysuckle 15g are weighed in prescription ratio, by L9 (34) orthogonal
Experimental condition carries out alcohol extracting；Campanulaceae 10g, Fructus Forsythiae 10g, peppermint 10g, windproof 8g, dark plum 8g, Schisandra chinensis 8g are weighed in prescription ratio
With radix glycyrrhizae 6g, totally 9 parts, extracted by extraction process by water condition, alcohol extract and upper liquid mixing are concentrated under reduced pressure into obtain density as 1.05
Concentrate, concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and medicinal powder is obtained, as sample.
3. test specimen Content of Chlorogenic Acid measures
Chromatographic condition and system suitability test：Using octadecylsilane chemically bonded silica as filler, with methanol-acetonitrile-
The sodium dihydrogen phosphate (glacial acetic acid tune pH is 3.0)=10: 13: 77 of 0.01mol/L is used as mobile phase；Detection wavelength is
326nm；35 DEG C of column temperature.Number of theoretical plate is calculated by scutelloside peak is not less than 2500.
The preparation of reference substance solution:Take scutelloside reference substance appropriate, it is accurately weighed, add 50% methanol that every 1mL is made containing 432
The solution of μ g, as reference substance solution.
The preparation of test solution：Precision weighs sample 0.5g, and precision adds 50% methanol solution 50ml, weighed weight,
30min is ultrasonically treated, lets cool, lets cool, weigh, the weight of less loss is supplied with 50% methanol, is shaken up, is filtered, precision measures filtrate
5mL, is put into 25mL brown bottles, adds 50% methanol to be shaken up, up to test solution to scale.
Assay is accurate respectively to draw test solution and each 10 μ l of reference substance solution, and injecting chromatograph, records, and calculates
Content, the results are shown in Table 2 and table 3.
2 alcohol extracting orthogonal experiments of table
3 alcohol extracting orthogonal test analysis of variance table of table
| Difference source | SS | The free degree | Variation is square | F ratios | Conspicuousness |
| A | 0.04427 | 2 | 0.02214 | 0.050 | |
| B | 0.58623 | 2 | 0.29311 | 0.663 | P<0.05 |
| C | 0.12969 | 2 | 0.06485 | 0.147 | |
| D | 2.77766 | 2 | 1.38883 | 3.141 | P<0.05 |
| Amount to | 3.53785 | 8 |
It was found from upper table interpretation of result, each factor effect primary and secondary is D>B>C>A, A factor influence alcohol extracting than other factors
It is small；B, two factors of D have a significant difference, B2 in factor B>B1>B3, should select B2 as alcohol extraction process parameter；D2 in factor D>
D1>D3, should select D2 as alcohol extraction process parameter；There was no significant difference for factor A, C, and with reference to big produce reality, A factors select A2, C because
Element selects C2.Therefore selection alcohol extraction process condition be A2, B2, C2, D2, i.e., plus 7 times are measured 70% ethanol, heating and refluxing extraction 3 times, every time
1.5 it is small when.
4. it is preferred that alcohol extracting process conditions are verified
Medicinal material flower bud of lily magnolia 20g, achene of Siberian cocklebur 15g, radix stellariae dichotomae 10g and honeysuckle 15g are weighed in prescription ratio, totally 3 parts, by alcohol extracting
Process conditions extract, i.e., plus 7 times amount 70% ethanol, heating and refluxing extraction 3 times, every time 1.5 it is small when, alcohol extract is spare；By prescription
Ratio weighs campanulaceae 10g, Fructus Forsythiae 10g, peppermint 10g, windproof 8g, dark plum 8g, Schisandra chinensis 8g and radix glycyrrhizae 6g, is carried out by extraction process by water
Decoct water to carry, take upper liquid after Aqueous extracts alcohol precipitation, alcohol extract and upper liquid mixing be concentrated under reduced pressure into obtain density be 1.05 it is dense
Contracting liquid, concentrate are dried to obtain medicinal extract extract, pulverize and sieve, and obtain medicinal powder, and as sample, the chlorogenic acid in determination sample contains
Amount, verifies three batches, checking test the results are shown in Table 4.
The orthogonal verification result table of 4 alcohol extracting of table
Learnt by upper table result, checking test result is consistent with orthogonal experiments, illustrate alcohol extraction process conditional stability,
It is feasible.
2nd, extraction process by water screens
Influencing the principal element that water decocts has：Decoct number, amount of water, decocting time etc..This experiment using this 3 factors as
Investigation factor, respectively takes 3 levels, carries out the experiment of 4 factor, 3 horizontal quadrature, screens extraction process by water condition, factor level table is shown in Table 5.
5 water of table carries quadrature factor water-glass
1. index selects
Carry out preferred abstract methods using the extracted amount of Phillyrin in Forsythia suspensa as evaluation index.
2. sample preparation
Medicinal material flower bud of lily magnolia 20g, achene of Siberian cocklebur 15g, radix stellariae dichotomae 10g and honeysuckle 15g are weighed in prescription ratio, totally 9 parts, by alcohol extracting
Process conditions are extracted, and alcohol extract is spare；In prescription ratio weigh campanulaceae 10g, Fructus Forsythiae 10g, peppermint 10g, windproof 8g, dark plum 8g,
Schisandra chinensis 8g and radix glycyrrhizae 6g, by L9 (34) orthogonal test condition carry out decoct water carry, upper liquid, alcohol extract are taken after Aqueous extracts alcohol precipitation
It is concentrated under reduced pressure into obtain the concentrate that density is 1.05 with upper liquid mixing, concentrate is dried to obtain medicinal extract extract, crushed
Sieve, obtains medicinal powder, as sample.
3. forsythin measures in test specimen
Chromatographic condition and system suitability test：Using octadecylsilane chemically bonded silica as filler, with acetonitrile-water=20
: 80 are used as mobile phase；Detection wavelength is 277nm；35 DEG C of column temperature.Number of theoretical plate is calculated by forsythin peak is not less than 2500.
The preparation of reference substance solution:Take forsythin reference substance appropriate, it is accurately weighed, add methanol that every 1mL is made and contain 50 μ g's
Solution, as reference substance solution.
The preparation of test solution：Precision weighs sample 4g, and precision adds methanol solution 50ml, and weighed weight, is heated back
30min is flowed, lets cool, weighs, the weight of less loss is supplied with methanol, is shaken up, is filtered, with 70% ethanol elution, collects eluent, water
Bath is evaporated, and residue is dissolved with ethanol, and constant volume shakes up in 10Ml volumetric flasks, is filtered for (0.45 μm) with miillpore filter, to obtain the final product.
Assay is accurate respectively to draw test solution and each 5 μ l of reference substance solution, and injecting chromatograph, records, and calculates
Content, the results are shown in Table 6 and table 7.
6 water of table puies forward orthogonal experiments
7 water of table carries orthogonal test analysis of variance table
| Difference source | SS | The free degree | Variation is square | F values | Conspicuousness |
| A | 0.52452 | 2 | 0.26226 | 3.7 | |
| B | 0.0401 | 2 | 0.02005 | 0.28 | |
| C | 5.26083 | 2 | 2.63042 | 37.13 | P<0.05 |
| Amount to | 5.96713 | 8 |
It was found from upper table interpretation of result, each factor effect primary and secondary is C>A>B, B factor influence water and put forward minimum, compare other factors
Influence small.C is because being known as significant difference, and C2 in factor C>C3>C1, then should select C2 as extraction process by water conditional parameter；Other
A, B there are no significant differences, A3 in factor A>A2>B3 in A1, factor B>B2>B1, according to the results of analysis of variance, has the conspicuousness poor
The different essential C2 of C factors, with reference to big produce reality, the selection of A, B factor A2, B2 that there was no significant difference are extraction process by water condition,
Therefore selection extraction process by water A2, B2, C2, that is, decoct it is secondary, add 9 times amount water, every time extraction 1.5 it is small when.
4. it is preferred that extraction process by water condition Verification
Medicinal material flower bud of lily magnolia 20g, achene of Siberian cocklebur 15g, radix stellariae dichotomae 10g and honeysuckle 15g are weighed in prescription ratio, totally 3 parts, by alcohol extracting
Process conditions are extracted, and alcohol extract is spare；In prescription ratio weigh campanulaceae 10g, Fructus Forsythiae 10g, peppermint 10g, windproof 8g, dark plum 8g,
Schisandra chinensis 8g and radix glycyrrhizae 6g, by extraction process by water A2, B2, C2, that is, decocts secondary, 9 times of amount water, when extraction 1.5 is small every time, are decocted
It is to boil water to carry, upper liquid is taken after Aqueous extracts alcohol precipitation, alcohol extract and upper liquid mixing are concentrated under reduced pressure into obtain the concentration that density is 1.05
Liquid, concentrate are dried to obtain medicinal extract extract, pulverize and sieve, and obtain medicinal powder, and as sample, the forsythin in determination sample contains
Amount, verifies three batches, checking test the results are shown in Table 8.
8 water of table carries orthogonal verification result table
Learnt by upper table result, checking test result is consistent with orthogonal experiments, illustrate extraction process by water conditional stability,
It is feasible.
3rd, alcohol precipitation process is investigated
The factor for influencing water extract-alcohol precipitation mainly has alcohol content, time of repose etc., this experiment is with alcohol content, time of repose 2
Factor respectively takes 3 levels, and factor level is shown in Table 9.In prescription ratio weigh medicinal material flower bud of lily magnolia 20g, achene of Siberian cocklebur 15g, radix stellariae dichotomae 10g and
Honeysuckle 15g, 9 parts, is extracted, alcohol extract is spare totally by alcohol extraction process condition；In prescription ratio weigh campanulaceae 10g, Fructus Forsythiae 10g,
Peppermint 10g, windproof 8g, dark plum 8g, Schisandra chinensis 8g and radix glycyrrhizae 6g, are extracted by extraction process by water condition, and Aqueous extracts are divided into nine parts, press
Four factors, three horizontal quadrature tests L9 (34) requirement carry out alcohol precipitation orthogonal test, upper liquid is taken after alcohol precipitation, by alcohol extract and upper
Layer liquid mixing is concentrated under reduced pressure to give concentrate, and concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and medicinal powder is obtained, as sample
Product.Sample presses abstract methods method containing survey determination sample content, preferably carry out variance analysis orthogonal to alcohol precipitation, alcohol precipitation condition, knot
Fruit is shown in Table 10, table 11.
9 water extract-alcohol precipitation orthogonal test factor level of table
| Number of levels | Alcohol content A (%) | Time of repose B (h) |
| 1 | 60 | 8 |
| 2 | 70 | 12 |
| 3 | 80 | 16 |
10 water extract-alcohol precipitation orthogonal experiments of table
11 water extract-alcohol precipitation orthogonal test analysis of variance table of table
| Difference source | SS | The free degree | Variation is square | F values | Conspicuousness |
| A | 4.01508 | 2 | 2.00754 | 18101.52 | P<0.05 |
| B | 0.15885 | 2 | 0.07942 | 716.14 | |
| Amount to | 4.17437 | 8 |
Learnt from upper table interpretation of result, each factor effect primary and secondary is A>B, A are because being known as significant difference, and A2 in factor A>
A1>A3, then should select A2 as alcohol precipitation process conditional parameter；B1 in factor B>B3>B2, with reference to big produce reality, B factors selection B1
For aqueous extraction-alcohol precipitation technology condition, therefore select alcohol precipitation process A2, B1, i.e., plus ethanol makes alcohol content be 70%, stand 8 it is small when.
4th, the screening of monarch drug in a prescription proportioning
Influence proportioning of the principal element in the monarch drug in a prescription in prescription of drug effect.Used in this experiment by adjusting different monarchs drug in a prescription
Amount, is prepared medicament respectively, and medicament is used in mice ear experiment, so as to finally select the amount ranges of monarch drug in a prescription.
Monarch drug in a prescription dosage is measured according to table 12, then takes campanulaceae 10g, Fructus Forsythiae 10g, peppermint 10g, windproof 8g, dark plum 8g, Schisandra chinensis 8g and radix glycyrrhizae
6g, medicament is made according to preparation process.
Table 12
| Sample number into spectrum | Flower bud of lily magnolia dosage g | Achene of Siberian cocklebur dosage g |
| 1 | 5 | 8 |
| 2 | 10 | 10 |
| 3 | 20 | 15 |
| 4 | 30 | 25 |
| 5 | 40 | 35 |
Healthy mice 60 is taken, male, female are fifty-fifty, are divided into 6 groups, every group 10, i.e. blank group, 1 group of sample, sample 2
5 groups of group, 3 groups of sample, 4 groups of sample and sample.Every is administered once daily, and 14d is administered, after the last administration 60min, mouse right ear
Uniformly smear dimethylbenzene 0.03mL/ only to cause to swell, ears are cut after 2h beat auricle and weigh, calculating ear swelling value (mg).Ear swelling value
(mg)=auris dextra weight-left ear weight.As a result it is as shown in table 13.
Table 13
| Sample | Dosage (g/kg) | Ear swelling value (mg) |
| Blank group | - | 13.82 |
| Sample 1 | 0.6 | 12.87 |
| Sample 2 | 0.6 | 7.97 |
| Sample 3 | 0.6 | 6.58 |
| Sample 4 | 0.6 | 7.71 |
| Sample 5 | 0.6 | 9.11 |
As shown in Table 13, when monarch drug in a prescription dosage is reduced, the effect effect unobvious of dimethylbenzene inducing mouse ear swelling is suppressed
When monarch drug in a prescription dosage is excessive, although having the function that to suppress dimethylbenzene inducing mouse ear swelling, action effect is poor.Work as the flower bud of lily magnolia
When taking the 10~30g, the achene of Siberian cocklebur to take 10~25g, product of the present invention is respectively provided with the work for significantly inhibiting dimethylbenzene inducing mouse ear swelling
With showing that product of the present invention has excellent anti-inflammatory effect.When especially taking flower bud of lily magnolia 20g, achene of Siberian cocklebur 15g, gained pharmacy effect
It is more excellent.
The effect of in order to verify the preparation of present invention treatment rhinitis chronic, inventor sees infective use
Examine.
Randomly select 200 patients with rhinitis and carry out clinical test, wherein male patient and female patient is fifty-fifty, year
Age is 1 month to 5 years in 15~55 one full year of life, the course of disease, and disease includes chronic simple rhinitis and chronic hypertrophic rhinitis.Usage is used
Amount：Every capsule 0.4g containing crude drug, three times a day, 3~4 every time, 14 days as a treatment course, observe a course for the treatment of.Therapeutic effect point
For 4 grades：1 grade-recovery from illness；2 grades-improve more than 76%；3 grades-improve 51%~75%.4 grades-invalid.As a result such as 14~table of table 18
It is shown.
The effect of 14 embodiment 1 of table
The effect of 15 embodiment 2 of table
The effect of 16 embodiment 3 of table
The effect of 17 embodiment 4 of table
The effect of 18 embodiment 5 of table
From 14~table of table 18, significantly (refractory patient is due to that self reason does not have to the clinical effectiveness of product of the present invention
Continuous medication).In subsequent follow-up, recurrent cases are not more than 3, show low using the recurrence rate of product of the present invention.And
Patient does not occur the serious adverse reactions such as allergy over the course for the treatment of.
The invention has the beneficial effects that：A kind of preparation for treating rhinitis chronic provided by the invention, said preparation treatment nose
Scorching cure rate is high, and therapeutic effect is good, quick.The flower bud of lily magnolia and the achene of Siberian cocklebur are selected in invention formulation as monarch drug in a prescription, radix stellariae dichotomae, gold
Honeysuckle flower is ministerial drug, is aided with adjutant and makes medicine, each efficacy of drugs synergistic effect, is controlled in outer disease, gained preparation is treated both principal and secondary aspect of disease, and is improved
Curative effect.The preparation pin of the present invention can rhinitis chronic treated, therapeutic effect is good, and cure rate is high, and recurrence rate is low.Invention formulation
Thing is without side-effects, safe.The cost of invention formulation is low, alleviates medical expense.Preparation preparation side provided by the invention
Method is easy to operate, and condition is easy to control.
Embodiment
The present invention is further introduced below in conjunction with specific embodiment.
Embodiment 1
A kind of preparation for treating rhinitis chronic, in parts by weight, takes 10 parts of the flower bud of lily magnolia, 10 parts of the achene of Siberian cocklebur, radix stellariae dichotomae 5
3 parts of part, 10 parts of honeysuckle, 5 parts of campanulaceae, 7 parts of Fructus Forsythiae, 6 parts of peppermint, 5 parts windproof, 4 parts of dark plum, 3 parts of Schisandra chinensis and radix glycyrrhizae, are made
Medicinal powder, then adds auxiliary material and various pharmaceutical preparations is made to obtain the final product.
Embodiment 2
A kind of preparation for treating rhinitis chronic, in parts by weight, takes 30 parts of the flower bud of lily magnolia, 25 parts of the achene of Siberian cocklebur, radix stellariae dichotomae 15
Part, 25 parts of honeysuckle, 15 parts of campanulaceae, 18 parts of Fructus Forsythiae, 20 parts of peppermint, 15 parts windproof, 12 parts of dark plum, 16 parts of Schisandra chinensis and radix glycyrrhizae 12
Part, medicinal powder is made, then adds auxiliary material and various pharmaceutical preparations is made to obtain the final product.
Embodiment 3
A kind of preparation for treating rhinitis chronic, in parts by weight, takes 20 parts of the flower bud of lily magnolia, 15 parts of the achene of Siberian cocklebur, radix stellariae dichotomae 10
6 parts of part, 15 parts of honeysuckle, 10 parts of campanulaceae, 10 parts of Fructus Forsythiae, 10 parts of peppermint, 8 parts windproof, 8 parts of dark plum, 8 parts of Schisandra chinensis and radix glycyrrhizae,
Medicinal powder is made, then adds auxiliary material and various pharmaceutical preparations is made to obtain the final product.
Embodiment 4
A kind of preparation for treating rhinitis chronic, in parts by weight, takes 15 parts of the flower bud of lily magnolia, 20 parts of the achene of Siberian cocklebur, radix stellariae dichotomae 12
Part, 20 parts of honeysuckle, 8 parts of campanulaceae, 8 parts of Fructus Forsythiae, 15 parts of peppermint, 12 parts windproof, 10 parts of dark plum, 13 parts of Schisandra chinensis and radix glycyrrhizae 10
Part, medicinal powder is made, then adds auxiliary material and various pharmaceutical preparations is made to obtain the final product.
Embodiment 5
A kind of preparation for treating rhinitis chronic, in parts by weight, takes 23 parts of the flower bud of lily magnolia, 16 parts of the achene of Siberian cocklebur, radix stellariae dichotomae 9
9 parts of part, 17 parts of honeysuckle, 10 parts of campanulaceae, 14 parts of Fructus Forsythiae, 11 parts of peppermint, 7 parts windproof, 6 parts of dark plum, 8 parts of Schisandra chinensis and radix glycyrrhizae,
Medicinal powder is made, then adds auxiliary material and various pharmaceutical preparations is made to obtain the final product.
Embodiment 1-5 traditional Chinese medicine powders can be prepared by mode in example 6 below -9.
Embodiment 6
The flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae, honeysuckle, campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and sweet are taken respectively
Grass, cleaning, after drying, is ground into medicinal powder.
Embodiment 7
Medicinal powder is through the following steps that be made：By the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae and honeysuckle is measured, add 6 times of 80% second of amount
Alcohol, refluxing extraction 4 times, each 1h, filtering, obtains alcohol extract, spare；By measurement campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, the five tastes
Son and radix glycyrrhizae, add the water of 8 times of amounts, decoct extraction 3 times, each 1h, and filtering, is concentrated under reduced pressure, obtains Aqueous extracts, then add ethanol,
Stir evenly, control concentration of alcohol in feed liquid 70%, to stand 8h, take upper liquid, it is spare；Alcohol extract and upper liquid are mixed,
It is concentrated under reduced pressure into obtain the concentrate that density is 1.05, concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and obtains medicinal powder.
Embodiment 8
Medicinal powder is through the following steps that be made：By the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae and honeysuckle is measured, add 8 times of 60% second of amount
Alcohol, refluxing extraction 2 times, each 2h, filtering, obtains alcohol extract, spare；By measurement campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, the five tastes
Son and radix glycyrrhizae, add the water of 10 times of amounts, decoct extraction 1 time, each 2h, and filtering, is concentrated under reduced pressure, obtains Aqueous extracts, then add ethanol,
Stir evenly, control concentration of alcohol in feed liquid 70%, to stand 8h, take upper liquid, it is spare；Alcohol extract and upper liquid are mixed,
It is concentrated under reduced pressure into obtain the concentrate that density is 1.05, concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and obtains medicinal powder.
Embodiment 9
Medicinal powder is through the following steps that be made：By the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae and honeysuckle is measured, add 7 times of 70% second of amount
Alcohol, refluxing extraction 3 times, each 1.5h, filtering, obtains alcohol extract, spare；By measurement campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, five
Taste and radix glycyrrhizae, add the water of 9 times of amounts, decoct extraction 2 times, each 1.5h, filtering, is concentrated under reduced pressure, obtains Aqueous extracts, then add second
Alcohol, stirs evenly, and controls concentration of alcohol in feed liquid 70%, to stand 8h, take upper liquid, spare；Alcohol extract and upper liquid are mixed
Close, be concentrated under reduced pressure into obtain the concentrate that density is 1.05, concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and obtains medicine
Powder.
Above medicinal powder can be prepared into powder, decoction, granule, tablet, capsule, oral liquid, the water-bindered pill or dripping pill.
Powder of getting it filled is prepared into various pharmaceutical preparations by one of mode in embodiment 10.
Embodiment 10
1. powder of getting it filled, adds starch as adhesive, adds water stirring, be put into after being pressed into bar in plodder, then use pill
Mechanism pelletization, up to the water-bindered pill；Three times a day, each 3g；
2. taking millet or the hawthorn of a diameter of 0.9~1mm, medicinal powder is sprayed, it is round as a ball, screen, shaping, adds complementary component
Capping, to obtain the final product；Three times a day, each 3g；
3. powder of getting it filled is directly loadable into capsule up to capsule.Three times a day, each 3g.
Claims (10)
- A kind of 1. preparation for treating rhinitis chronic, it is characterised in that：Take the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae, honeysuckle, campanulaceae, company Stick up, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae, medicinal powder is made, then adds auxiliary material and various pharmaceutical preparations is made to obtain the final product.
- 2. the preparation for the treatment of rhinitis chronic according to claim 1, it is characterised in that：The medicinal powder that is made refers to take respectively The flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae, honeysuckle, campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae, cleaning, after drying, It is ground into medicinal powder.
- 3. the preparation for the treatment of rhinitis chronic according to claim 1, it is characterised in that：The medicinal powder through the following steps that It is made：By the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae and honeysuckle is measured, add ethanol, refluxing extraction, filtering, obtains alcohol extract, spare；According to quantity Campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae are taken, adds water, decocts extraction, filtering, be concentrated under reduced pressure to obtain Aqueous extracts, Ethanol is then added, is stirred evenly, stands, takes upper liquid, it is spare；Alcohol extract and upper liquid are mixed, are concentrated under reduced pressure to give dense Contracting liquid, concentrate are dried to obtain medicinal extract extract, pulverize and sieve, and obtain medicinal powder.
- 4. the preparation for the treatment of rhinitis chronic according to claim 3, it is characterised in that：The medicinal powder through the following steps that It is made：By the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae and honeysuckle is measured, add 6~8 times of 60%~80% ethanol of amount, refluxing extraction 2~4 Secondary, each 1h~2h, filtering, obtains alcohol extract, spare；By measuring campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae, Add the water of 8~10 times of amounts, decoct extraction 1~3 time, each 1h~2h, filtering, is concentrated under reduced pressure, obtains Aqueous extracts, then add second Alcohol, stirs evenly, and controls concentration of alcohol in feed liquid 70%, to stand 8h, take upper liquid, spare；Alcohol extract and upper liquid are mixed Close, be concentrated under reduced pressure into obtain the concentrate that density is 1.05, concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and obtains medicine Powder.
- 5. the preparation for the treatment of rhinitis chronic according to claim 4, it is characterised in that：The medicinal powder through the following steps that It is made：By the flower bud of lily magnolia, the achene of Siberian cocklebur, radix stellariae dichotomae and honeysuckle is measured, add 7 times of 70% ethanol of amount, refluxing extraction 3 times, each 1.5h, mistake Filter, obtains alcohol extract, spare；By campanulaceae, Fructus Forsythiae, peppermint, windproof, dark plum, Schisandra chinensis and radix glycyrrhizae is measured, add the water of 9 times of amounts, decoct Extraction 2 times, each 1.5h, filtering, is concentrated under reduced pressure, obtains Aqueous extracts, then add ethanol, stir evenly, and controls ethanol in feed liquid Concentration stands 8h, takes upper liquid 70%, spare；Alcohol extract and upper liquid are mixed, are concentrated under reduced pressure into obtain density as 1.05 Concentrate, concentrate is dried to obtain medicinal extract extract, pulverizes and sieves, and obtains medicinal powder.
- 6. the preparation for the treatment of rhinitis chronic according to claim 1, it is characterised in that：In parts by weight, the flower bud of lily magnolia is taken 10~30 parts, 10~25 parts of the achene of Siberian cocklebur, 5~15 parts of radix stellariae dichotomae, 10~25 parts of honeysuckle, 5~15 parts of campanulaceae, 7~18 parts of Fructus Forsythiae, 3~12 parts of 6~20 parts of peppermint, 5~15 parts windproof, 4~12 parts of dark plum, 3~16 parts of Schisandra chinensis and radix glycyrrhizae.
- 7. the preparation for the treatment of rhinitis chronic according to claim 1, it is characterised in that：In parts by weight, the flower bud of lily magnolia is taken 15~30 parts, 10~20 parts of the achene of Siberian cocklebur, 5~12 parts of radix stellariae dichotomae, 10~20 parts of honeysuckle, 8~15 parts of campanulaceae, 8~18 parts of Fructus Forsythiae, 3~10 parts of 6~15 parts of peppermint, 5~12 parts windproof, 4~10 parts of dark plum, 3~13 parts of Schisandra chinensis and radix glycyrrhizae.
- 8. the preparation for the treatment of rhinitis chronic according to claim 1, it is characterised in that：In parts by weight, the flower bud of lily magnolia is taken 20 parts, 15 parts of the achene of Siberian cocklebur, 10 parts of radix stellariae dichotomae, 15 parts of honeysuckle, 10 parts of campanulaceae, 10 parts of Fructus Forsythiae, 10 parts of peppermint, 8 parts windproof, dark plum 6 parts of 8 parts, 8 parts of Schisandra chinensis and radix glycyrrhizae.
- 9. the preparation of rhinitis chronic is treated according to claim 1~8 any one of them, it is characterised in that：The pharmaceutical preparation For powder, decoction, granule, tablet, capsule, oral liquid, the water-bindered pill or dripping pill.
- 10. the preparation for the treatment of rhinitis chronic according to claim 9, it is characterised in that：The pharmaceutical preparation is using following It is prepared by one of mode：1. powder of getting it filled, adds starch as adhesive, adds water stirring, be put into after being pressed into bar in plodder, then with pill mechanism Pelletization, up to the water-bindered pill；2. taking millet or the hawthorn of a diameter of 0.9~1mm, medicinal powder is sprayed, it is round as a ball, screen, shaping, adds complementary component lid Face, to obtain the final product；3. powder of getting it filled is directly loadable into capsule up to capsule.
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|---|---|---|---|---|
| CN1958003A (en) * | 2005-10-31 | 2007-05-09 | 北京奇源益德药物研究所 | Preparation for treating chronic nasosinusitis, preparation method and quality control method |
| CN101112499A (en) * | 2007-08-22 | 2008-01-30 | 武汉中联药业集团股份有限公司 | Chinese traditional medicine compound preparations for treating rhinitis |
| CN103007096A (en) * | 2012-12-25 | 2013-04-03 | 臧金文 | Preparation raw materials of dropping liquid for treating rhinitis and tympanitis and production process thereof |
| CN105326908A (en) * | 2015-12-08 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Medicine composition for treating rhinitis and application thereof |
| CN106310096A (en) * | 2016-09-19 | 2017-01-11 | 四川易创生物科技有限公司 | Decoction pharmaceutical for treating allergic rhinitis and preparation method thereof |
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2017
- 2017-11-13 CN CN201711116724.2A patent/CN107929387A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958003A (en) * | 2005-10-31 | 2007-05-09 | 北京奇源益德药物研究所 | Preparation for treating chronic nasosinusitis, preparation method and quality control method |
| CN101112499A (en) * | 2007-08-22 | 2008-01-30 | 武汉中联药业集团股份有限公司 | Chinese traditional medicine compound preparations for treating rhinitis |
| CN103007096A (en) * | 2012-12-25 | 2013-04-03 | 臧金文 | Preparation raw materials of dropping liquid for treating rhinitis and tympanitis and production process thereof |
| CN105326908A (en) * | 2015-12-08 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Medicine composition for treating rhinitis and application thereof |
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