[go: up one dir, main page]

CN107928769A - A kind of tumor intervention therapeutic device - Google Patents

A kind of tumor intervention therapeutic device Download PDF

Info

Publication number
CN107928769A
CN107928769A CN201711459540.6A CN201711459540A CN107928769A CN 107928769 A CN107928769 A CN 107928769A CN 201711459540 A CN201711459540 A CN 201711459540A CN 107928769 A CN107928769 A CN 107928769A
Authority
CN
China
Prior art keywords
cross bar
magnetic pole
permanent magnet
electromagnet
frame body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201711459540.6A
Other languages
Chinese (zh)
Other versions
CN107928769B (en
Inventor
周燚
徐中佑
熊明敏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
People's Government Of Tibet Autonomous Region In Chengdu Office Hospital
Original Assignee
People's Government Of Tibet Autonomous Region In Chengdu Office Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by People's Government Of Tibet Autonomous Region In Chengdu Office Hospital filed Critical People's Government Of Tibet Autonomous Region In Chengdu Office Hospital
Priority to CN201711459540.6A priority Critical patent/CN107928769B/en
Publication of CN107928769A publication Critical patent/CN107928769A/en
Application granted granted Critical
Publication of CN107928769B publication Critical patent/CN107928769B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/34Trocars; Puncturing needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/34Trocars; Puncturing needles
    • A61B17/3403Needle locating or guiding means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/34Trocars; Puncturing needles
    • A61B17/3403Needle locating or guiding means
    • A61B2017/3405Needle locating or guiding means using mechanical guide means
    • A61B2017/3407Needle locating or guiding means using mechanical guide means including a base for support on the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses a kind of tumor intervention therapeutic device, including frame body, needle handle and needle body, the upper end of needle body is fixedly connected by cross bar with permanent magnet, and permanent magnet is slidably connected with the vertical rails being fixed on frame body, one magnetic pole of permanent magnet is upward, another magnetic pole is downward;The upper end of vertical rails is fixed with the electromagnet above permanent magnet, and a magnetic pole of electromagnet is upward, another magnetic pole is downward, and the downward magnetic pole of electromagnet is opposite with the upward magnetic pole of permanent magnet and is homopolarity magnetic pole;The resetting spring being connected between cross bar and frame body above cross bar;Electromagnet is electrically connected by power switch with power module;Be equipped with lower position block below cross bar, lower position block be used for cross bar to move downward generation spacing.The present invention is moved downward come biopsy needle guide by electromagnetic repulsion and carries out tumor puncture to patient, its paracentesis depth is adjustable, and puncture position is accurate, and puncture procedure is convenient, alleviates the puncture pain of patient, it is possible to increase puncture working efficiency is low.

Description

A kind of tumor intervention therapeutic device
Technical field
The present invention relates to medical instruments field, more particularly to a kind of tumor intervention therapeutic device.
Background technology
In current treatment technology, be typically necessary for oncotherapy is made using carcinoma intervention puncture needle, present hospital Its structure of carcinoma intervention puncture needle is identical with common puncture needle, is made of needle body and needle handle, but in practical operation, When carrying out tumor intervention therapeutic to patient using common puncture needle, since the needle handle of common puncture needle is shorter, thus easily Generation cross-infection, difficulty is brought to staff's operation;In addition present institute is all to need to be manually operated needle handle using puncture needle, Due to different tumours, its size is different, and the depth punctured is also different, and punctures manually and be not easy assurance and wear Depth is pierced, reduces puncture effect, simultaneously because puncturing manually not accurate enough, is not easy to position in piercing process, and punctures dynamics Also it is difficult to hold, therefore causes tumor puncture inconvenient, while add the puncture pain of patient, also results in work efficiency It is low.
The content of the invention
The purpose of the present invention is overcome above-mentioned problems of the prior art, there is provided a kind of tumor intervention therapeutic device, It is moved downward come biopsy needle guide by electromagnetic repulsion and carries out tumor puncture to patient, its paracentesis depth is adjustable, punctures position It is accurate to put, and puncture procedure is convenient, alleviates the puncture pain of patient, it is possible to increase puncture working efficiency is low.
The technical scheme is that:A kind of tumor intervention therapeutic device, including frame body, needle handle and needle body, the pin The upper end of body is connected with needle handle, and the upper end of the needle body is fixedly connected by cross bar with permanent magnet, and the permanent magnet is with being fixed on Vertical rails on frame body are slidably connected, and a magnetic pole of the permanent magnet is upward, another magnetic pole is downward;The vertical rails Upper end be fixed with electromagnet above the permanent magnet, a magnetic pole of the electromagnet is upward, another magnetic pole to Under, the downward magnetic pole of electromagnet is opposite with the upward magnetic pole of permanent magnet and is homopolarity magnetic pole;Between the cross bar and frame body The resetting spring being connected with above cross bar;The electromagnet is electrically connected by power switch with power module;The cross bar Lower section be equipped with lower position block, the lower position block be used for cross bar move downward produce it is spacing.
The top of above-mentioned cross bar is equipped with upper limit position block, and the upward movement that the upper limit position block is used for cross bar produces spacing; The resetting spring is longitudinally disposed, when between electromagnet and permanent magnet without magneticaction, the phase of the electromagnet and permanent magnet To pulling force of the magnetic pole when resetting spring is static under it is mutually close, the upper limit position block is in contact with cross bar and to horizontal stroke just at this time Bar forms upper limit.
Above-mentioned lower position block is fixed on the upper end of length-adjustable vertical telescopic rod, and the vertical telescopic rod is fixed on frame body On, the lower position block forms cross bar adjustable lower limit position by the length adjustment of vertical telescopic rod.
Vertically arranged altitude scale ruler is further fixed on above-mentioned frame body, when between the electromagnet and permanent magnet without magnetic force Effect and cross bar is when remaining static, upper end and the cross bar of the altitude scale ruler are located in same level.
Above-mentioned lower position block is fixed on vertically arranged screw rod upper end, and the screw flight, which is connected to, to be opened on frame body In threaded hole, the screw rod rotates the height adjusting for forming screw rod, the height that the lower position block passes through screw rod in threaded hole Adjusting forms the cross bar adjustable lower limit position.
Bumper and absorbing shock pad is respectively equipped with above-mentioned upper limit position block and lower position block.
Above-mentioned frame body is equipped with vertical guide cylinder, and the needle body is passed through from the guide cylinder.
The lower end of above-mentioned frame body is equipped with multiple legs, and connecting rod is equipped with each leg, is equipped with and is located between each connecting rod Locating ring immediately below the needle point of the needle body, the locating ring be used for be positioned over tumour top position with accurately to tumour into Row positioning, accurately punctures tumour so that the needle body is passed through from locating ring just.
Thimerosal spraying device is additionally provided with above-mentioned frame body.
Above-mentioned power module includes 2-3 grades of different output voltage supplies, and voltage can be changed by voltage change-over switch Supply gear.
Beneficial effects of the present invention:A kind of tumor intervention therapeutic device is provided in the embodiment of the present invention, is pushed away by electromagnetism Repulsion carrys out biopsy needle guide and moves downward to patient's progress tumor puncture, its paracentesis depth is adjustable, and puncture position is accurate, punctures behaviour Facilitate, alleviate the puncture pain of patient, it is possible to increase puncture working efficiency is low.
Brief description of the drawings
Fig. 1 is the overall structure diagram of the present invention;
Fig. 2 is the structure diagram adjusted using screw rod as lower position block position;
The electric system that Fig. 3 is the present invention connects block diagram.
Embodiment
Below in conjunction with the accompanying drawings, the specific embodiment of the present invention is described in detail, it is to be understood that of the invention Protection domain and from the limitation of embodiment.
As shown in Figure 1, an embodiment of the present invention provides a kind of tumor intervention therapeutic device, including frame body 3, needle handle 1 and Needle body 2, the upper end of the needle body 2 are connected with needle handle 1, and the upper end of the needle body 2 is fixedly connected by cross bar 5 with permanent magnet 6, institute Permanent magnet 6 to be stated to be slidably connected with the vertical rails 14 being fixed on frame body 3, a magnetic pole of the permanent magnet 6 is upward, another Magnetic pole is downward;The upper end of the vertical rails 14 is fixed with the electromagnet 13 above the permanent magnet 6, the electromagnet 13 A magnetic pole it is upward, another magnetic pole is downward, the downward magnetic pole of electromagnet 13 it is opposite with the upward magnetic pole of permanent magnet 6 and For homopolarity magnetic pole;The resetting spring 8 being connected between the cross bar 5 and frame body 3 above cross bar 5;The electromagnet 13 is logical Power switch is crossed to be electrically connected with power module 10;The lower section of the cross bar 5 is equipped with lower position block 12, and the lower position block 12 is used for To cross bar 5 move downward produce it is spacing.
Further, the top of the cross bar 5 is equipped with upper limit position block 4, and the upper limit position block 4 is used for the upward of cross bar 5 Movement produces spacing;The resetting spring 8 is longitudinally disposed, when between electromagnet 13 and permanent magnet 6 without magneticaction, the electricity The magnetic pole opposite with permanent magnet 6 of magnet 13 is mutually close under the pulling force when resetting spring 8 is static, and mutually close distance is 0.5- 0.8cm, at this time the upper limit position block 4 be in contact just with cross bar 5 and to cross bar 5 formed upper limit.
Further, the lower position block 12 is fixed on the upper end of length-adjustable vertical telescopic rod 11, described vertically to stretch Contracting bar 11 is fixed on frame body 3, and the lower position block 12 forms cross bar 5 by the length adjustment of vertical telescopic rod 11 adjustable Lower limit position.Vertically arranged altitude scale ruler 9 is further fixed on the frame body 3, when the electromagnet 13 and permanent magnet 6 it Between when remaining static without magneticaction and cross bar 5, the upper end of the altitude scale ruler 9 is located at same water with the cross bar 5 In plane.
Further, referring to Fig. 2, the lower position block 12 is fixed on vertically arranged 19 upper end of screw rod, the screw rod 19 It is threadedly connected in the threaded hole being opened on frame body 3, the screw rod 19 rotates the height tune for forming screw rod 19 in threaded hole Section, the lower position block 12 are adjusted by the height of screw rod 19 and form adjustable lower limit position to the cross bar 5.
Further, it is respectively equipped with bumper and absorbing shock pad on the upper limit position block 4 and lower position block 12.
Further, the frame body 3 is equipped with vertical guide cylinder 7, and the needle body 2 is passed through from the guide cylinder 7.
Further, the lower end of the frame body 3 is equipped with multiple legs 18, is equipped with connecting rod 16 on each leg 18, respectively connects The locating ring 17 being equipped between extension bar 16 immediately below the needle point of the needle body 2, the locating ring 17 are used to be positioned over tumour Top position carries out standard accurately to be positioned to tumour, so that the needle body 2 is passed through from locating ring 17 just to tumour Really puncture.
Further, it is additionally provided with thimerosal spraying device 15 on the frame body 3.
Further, referring to Fig. 3, the power module 10 includes 2-3 grades of different output voltage supplies, is turned by voltage Voltage supply gear can be changed by changing switch.
The course of work of the present invention:By the way that the locating ring of the present invention is positioned at patient's tumor locus to be punctured, together When make what each leg stablized to be supported in around tumour body, the power switch of electromagnet is then opened, in the effect of electromagnetic repulsion force Under, permanent magnet and cross bar drive needle body to move downward, and enter so as to accurately puncture inside tumour body, until cross bar is by lower limit After block forms lower limit, piercing process terminates;According to the tumor size to be punctured, can vertically be stretched by realizing to adjust in advance The length of contracting bar (or screw rod 19), while the scale value on engagement height graduated scale determines paracentesis depth.After puncture, close Close power switch so that the magnetic repulsion between electromagnet and permanent magnet disappears, and under resetting spring pulling force effect, cross bar drives pin Body moves rapidly upward, so that needle body leaves tumour body.
In conclusion a kind of tumor intervention therapeutic device provided in an embodiment of the present invention, it is drawn by electromagnetic repulsion Puncture needle to be led to move downward to patient's progress tumor puncture, its paracentesis depth is adjustable, and puncture position is accurate, and puncture procedure is convenient, Alleviate the puncture pain of patient, it is possible to increase puncture working efficiency is low.
Disclosed above is only several specific embodiments of the present invention, and still, the embodiment of the present invention is not limited to this, is appointed What what those skilled in the art can think change should all fall into protection scope of the present invention.

Claims (10)

1. a kind of tumor intervention therapeutic device, including frame body (3), needle handle (1) and needle body (2), the upper end of the needle body (2) with Needle handle (1) connect, it is characterised in that the upper end of the needle body (2) is fixedly connected by cross bar (5) with permanent magnet (6), it is described forever Magnet (6) is slidably connected with the vertical rails (14) being fixed on frame body (3), and a magnetic pole of the permanent magnet (6) is upward, separately One magnetic pole is downward;The upper end of the vertical rails (14) is fixed with the electromagnet (13) above the permanent magnet (6), institute State that a magnetic pole of electromagnet (13) is upward, another magnetic pole is downward, downward magnetic pole and the permanent magnet (6) of electromagnet (13) Upward magnetic pole is opposite and is homopolarity magnetic pole;Answering above cross bar (5) is connected between the cross bar (5) and frame body (3) Position spring (8);The electromagnet (13) is electrically connected by power switch with power module (10);Set below the cross bar (5) Have a lower position block (12), the lower position block (12) be used for cross bar (5) move downward produce it is spacing.
2. a kind of tumor intervention therapeutic device as claimed in claim 1, it is characterised in that the top of the cross bar (5) is equipped with Upper limit position block (4), the upward movement that the upper limit position block (4) is used for cross bar (5) produce spacing;The resetting spring (8) is vertical To setting, when between electromagnet (13) and permanent magnet (6) without magneticaction, the phase of the electromagnet (13) and permanent magnet (6) To pulling force of the magnetic pole when resetting spring (8) is static under it is mutually close, at this time the upper limit position block (4) just with cross bar (5) phase Contact and upper limit is formed to cross bar (5).
3. a kind of tumor intervention therapeutic device as claimed in claim 1, it is characterised in that the lower position block (12) is fixed on The upper end of length-adjustable vertical telescopic rod (11), the vertical telescopic rod (11) are fixed on frame body (3), the lower position block (12) adjustable lower limit position is formed to cross bar (5) by the length adjustment of vertical telescopic rod (11).
4. a kind of tumor intervention therapeutic device as claimed in claim 3, it is characterised in that be further fixed on the frame body (3) Vertically arranged altitude scale ruler (9), when between the electromagnet (13) and permanent magnet (6) without magneticaction and cross bar (5) place When inactive state, upper end and the cross bar (5) of the altitude scale ruler (9) are located in same level.
5. a kind of tumor intervention therapeutic device as claimed in claim 1, it is characterised in that the lower position block (12) is fixed on Vertically arranged screw rod (19) upper end, the screw rod (19) are threadedly connected in the threaded hole being opened on frame body (3), the spiral shell Bar (19) rotates the height adjusting for forming screw rod in threaded hole, and the height that the lower position block (12) passes through screw rod (19) is adjusted Adjustable lower limit position is formed to the cross bar (5).
A kind of 6. tumor intervention therapeutic device as claimed in claim 2, it is characterised in that the upper limit position block (4) and under Limited block is respectively equipped with bumper and absorbing shock pad on (12).
7. a kind of tumor intervention therapeutic device as claimed in claim 1, it is characterised in that the frame body (3) is equipped with vertical Guide cylinder (7), the needle body (2) passes through from the guide cylinder (7).
8. a kind of tumor intervention therapeutic device as claimed in claim 1, it is characterised in that the lower end of the frame body (3) is equipped with Multiple legs (18), connecting rod (16) is equipped with each leg (18), is equipped between each connecting rod (16) and is located at the needle body (2) Needle point immediately below locating ring (17), the locating ring (17) be used for be positioned over tumour top position with accurately to tumour into Row positioning, accurately punctures tumour so that the needle body (2) is passed through from locating ring (17) just.
9. a kind of tumor intervention therapeutic device as claimed in claim 1, it is characterised in that be additionally provided with and disappear on the frame body (3) Venom spraying device (15).
10. a kind of tumor intervention therapeutic device as claimed in claim 1, it is characterised in that the power module (10) includes 2-3 grades of different output voltage supplies, can change voltage by voltage change-over switch and supply gear.
CN201711459540.6A 2017-12-28 2017-12-28 A kind of tumor intervention therapeutic device Expired - Fee Related CN107928769B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711459540.6A CN107928769B (en) 2017-12-28 2017-12-28 A kind of tumor intervention therapeutic device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711459540.6A CN107928769B (en) 2017-12-28 2017-12-28 A kind of tumor intervention therapeutic device

Publications (2)

Publication Number Publication Date
CN107928769A true CN107928769A (en) 2018-04-20
CN107928769B CN107928769B (en) 2019-09-10

Family

ID=61939599

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711459540.6A Expired - Fee Related CN107928769B (en) 2017-12-28 2017-12-28 A kind of tumor intervention therapeutic device

Country Status (1)

Country Link
CN (1) CN107928769B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110269581A (en) * 2019-07-24 2019-09-24 李振豪 A kind of magnetic control biopsy capsule endoscope and its application method
CN110975155A (en) * 2019-11-15 2020-04-10 山东大学齐鲁医院 A kind of marking device and method for radiotherapy marking line
CN111012457A (en) * 2020-01-08 2020-04-17 浙江省人民医院 A safe bone tumor biopsy device
CN114145815A (en) * 2021-11-08 2022-03-08 濮阳市安阳地区医院 Cardiovascular intervention device and operation method thereof
CN115553885A (en) * 2022-10-20 2023-01-03 哈尔滨理工大学 An electromagnetically driven puncture biopsy gun that can quickly replace the inner and outer puncture needles
CN116138837A (en) * 2023-02-28 2023-05-23 南京医科大学 Device for detecting lateral stress state of robot bone drilling tool and application method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101548898A (en) * 2007-11-20 2009-10-07 伊西康内外科公司 Biopsy device with motorized needle cocking
CN204863305U (en) * 2015-08-25 2015-12-16 哈尔滨理工大学 Single electromagnetic drive aspiration biopsy rifle
CN106037891A (en) * 2016-04-22 2016-10-26 河南科技大学第附属医院 A tumor interventional therapy device
CN107049434A (en) * 2017-05-25 2017-08-18 张婷英 Percutaneous renal puncture locator

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101548898A (en) * 2007-11-20 2009-10-07 伊西康内外科公司 Biopsy device with motorized needle cocking
CN204863305U (en) * 2015-08-25 2015-12-16 哈尔滨理工大学 Single electromagnetic drive aspiration biopsy rifle
CN106037891A (en) * 2016-04-22 2016-10-26 河南科技大学第附属医院 A tumor interventional therapy device
CN107049434A (en) * 2017-05-25 2017-08-18 张婷英 Percutaneous renal puncture locator

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110269581A (en) * 2019-07-24 2019-09-24 李振豪 A kind of magnetic control biopsy capsule endoscope and its application method
CN110975155A (en) * 2019-11-15 2020-04-10 山东大学齐鲁医院 A kind of marking device and method for radiotherapy marking line
CN111012457A (en) * 2020-01-08 2020-04-17 浙江省人民医院 A safe bone tumor biopsy device
CN111012457B (en) * 2020-01-08 2021-04-16 浙江省人民医院 Safe type bone tumour biopsy ware
CN114145815A (en) * 2021-11-08 2022-03-08 濮阳市安阳地区医院 Cardiovascular intervention device and operation method thereof
CN115553885A (en) * 2022-10-20 2023-01-03 哈尔滨理工大学 An electromagnetically driven puncture biopsy gun that can quickly replace the inner and outer puncture needles
CN116138837A (en) * 2023-02-28 2023-05-23 南京医科大学 Device for detecting lateral stress state of robot bone drilling tool and application method

Also Published As

Publication number Publication date
CN107928769B (en) 2019-09-10

Similar Documents

Publication Publication Date Title
CN107928769B (en) A kind of tumor intervention therapeutic device
CN204521567U (en) A kind of intelligent Chinese medicine acupuncture therapeutic instrument
CN203089244U (en) Abdomen minimally invasive retractor
CN103656858B (en) A kind of electromagnetic therapeutic apparatus and using method thereof
CN103432687B (en) A kind of multifunction electric Magnetotherapeutic apparatus
CN204246234U (en) A kind of guider of dept. of orthopedics
CN103691062A (en) Main and collateral channel therapeutic equipment and use method thereof
CN202843637U (en) X-ray protecting screen
CN210728217U (en) Traditional chinese medical science internal medicine diagnoses device
CN208114930U (en) A kind of oscillatory type crossbow medicine needle
CN202776570U (en) Hand-held brain puncture e-shaped orientator
CN102091368A (en) Quick and convenient injector
CN204033361U (en) Nuclear medicine radiation inspection treatment all-in-one
CN213788850U (en) Needle inserting device for traditional Chinese medicine acupuncture
CN204351940U (en) Department of neurology diagnosis and treatment instrument
CN208464105U (en) Knee joint varus or the stress position X-ray photographic fixator that turns up
CN208031748U (en) A kind of medical waist wound resumes training device
CN203264050U (en) Integral magnetic therapy device capable of adjusting magnetic field intensity and magnetic pole directions
CN204073120U (en) Multi-functional innovation mobile type radiation principle therapeutic instrument
CN206473459U (en) Eye socket subperiosteum space distraction device
CN206612951U (en) A kind of electronics cutaneous acupuncture
CN107174310A (en) A kind of ultrafine needle weapons
CN204073111U (en) Innovative bone wound resumes treatment instrument
CN113018171A (en) Moving magnetic field magnetic conduction needle resonance effect therapeutic instrument
CN102671293B (en) Action length-adjustable therapeutic electrode tip

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190910

Termination date: 20191228

CF01 Termination of patent right due to non-payment of annual fee