CN107898734B

CN107898734B - Application of agave extract in preparing external itching-relieving and moisturizing personal care product

Info

Publication number: CN107898734B
Application number: CN201810007426.8A
Authority: CN
Inventors: 管书旺
Original assignee: Shanghai Zibon Biological Pharmaceutical Co ltd
Current assignee: Shanghai Zibon Biological Pharmaceutical Co ltd
Priority date: 2018-01-04
Filing date: 2018-01-04
Publication date: 2021-08-31
Anticipated expiration: 2038-01-04
Also published as: CN107898734A

Abstract

The invention relates to an application of a agave extract in preparing an external personal care product with itching relieving and moisture preserving functions. The composition obtained by mixing the agave extract and the second component achieves the effects of synergistic itching relieving and moisturizing. The agave extract and the composition of the agave extract and the second component can be used in personal care cosmetics and have the itching relieving and moisturizing effects which are safe, effective and easy to absorb.

Description

Application of agave extract in preparing external itching-relieving and moisturizing personal care product

Technical Field

The invention belongs to the technical field of daily care products, and particularly relates to an application of a agave extract in preparing an external itching-relieving and moisturizing personal care product.

Background

The skin occupies the largest surface area of the body and acts as a protective layer for internal organs. Lack of proper skin care can lead to various skin problems such as dry skin, sagging, itching, roughness, spots, wrinkles, etc. These problems are caused by many reasons, such as environmental pollution, ultraviolet radiation, bacterial infection, skin sensitivity, and the like.

Under normal conditions, due to the water absorption effect and the barrier function of the stratum corneum and the covering effect of lipid substances secreted by sweat glands and sebaceous glands, water is not easy to lose, the stratum corneum can keep a certain water content, the water of the stratum corneum is increased and kept, and the skin can keep soft and keep elasticity. There are two main reasons for causing the stratum corneum to lack water and thus causing the skin to dry: firstly, the climate is dry and the relative humidity is low; secondly, the normal water absorption and barrier function of the skin are damaged, which becomes the cause of various skin diseases such as atopic dermatitis, so that the skin dryness is a considerable problem. Moisturizers in cosmetics mainly include the following categories: polyhydric alcohol moisturizers, hyaluronic acid moisturizers, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, ceramide moisturizers, amide moisturizers, glucose ester moisturizers, collagen moisturizers, chitin derivatives, chitosan and the like. They have drawbacks in some respects, such as: although glycerin, which is a polyhydric alcohol, absorbs moisture in the air to achieve a moisturizing effect, glycerin cannot form a protective film and has a deep moisturizing effect. The moisturizing effect of the hyaluronic acid solution is that a viscoelastic film is formed, which has a strong water-retaining property (as does hyaluronic acid in intercellular matrix of skin connective tissue), is completely transparent, does not leave marks and greasy feeling, and has a soft, smooth and lubricious feeling, but it cannot penetrate the horny layer of epidermis (even short chain hyaluronic acid degradation products of 5 to 10 disaccharide units do not easily pass through the horny layer of epidermis).

Pruritus is a common complication of sensitive skin, and cosmetics are mostly used in modern society regardless of men and women, old and young, but can induce skin irritation, inflammation, allergy, pruritus and the like.

Many substances causing skin itching are known, such as histamine, substance P, bradykinin, protease, prostaglandin, and morpholinopeptide, but it is a field in which research is progressing slowly because quantitative and objective evaluation is difficult.

The treatment of cutaneous pruritus is on the one hand based on drugs, but more importantly the patient is careful to care for the skin, overcoming scratching, which leads to a vicious circle of more and more itching, with further aggravation of the symptoms.

For the treatment of itching, antihistamines and antiallergic agents have been used as internal agents, while antihistamines, adrenocortical steroid agents, non-steroidal anti-inflammatory agents, camphor, menthol, phenol, salicylic acid, tar, crotamiton, capsaicin, or moisturizers (urea, heliotrope, vaseline, etc.) have been used as external agents. However, when the oral preparation is used, problems such as a certain period of time required for clinical effects, side effects (sleepiness and lassitude) on the central nervous system, and damage to the digestive system may occur. On the other hand, when the external preparation is used, the antipruritic effect is insufficient, and particularly when the steroid preparation is used for a long period of time, there are problems of general reactions such as decrease in adrenal function, rebound, skin atrophy, steroid purpura, skin atrophy spots, steroid acne and other local side effects.

The development trend of cosmetics in the world at present advocates green, natural, safe and environment-friendly cosmetics with certain efficacy. More and more consumers are looking for cosmetic manufacturers to develop more natural, effective skin care products to make the skin healthier. Therefore, the development of natural, mild and practical cosmetic ingredients has become essential for the development of new cosmetic products.

Agave is a plant produced in the semi-desert area of the volcanic plain with an altitude of 2500 m in mexico, and comprises several species of blue Agave (Agave tequila), black Agave (Agave salmina), green Agave, gray Agave, spiny Agave and rainbow Agave. The agave succus is rich in polysaccharide, and is often used for fermentation and brewing wine, and the agave wine has effects of reducing weight, promoting digestion, resisting osteoporosis, preventing type 2 diabetes, reducing senile dementia, improving sleep, etc.

The use of agave syrup as a skin moisturizing ingredient is described in chinese patent CN 102316848B; the anti-inflammatory effect of aqueous extracts of agave on mice is also described in the non-patent literature (Shuleya, et al, university of North China (Nature), 2(5):377-379 (2001)). In addition, the researchers of the project do not find the report of the agave extract and the composition as the skin external preparation in the aspects of relieving itching and moisturizing the skin.

Disclosure of Invention

In view of the above-mentioned blank in the art, the present invention provides a agave extract composition having antipruritic and moisturizing effects that can be used in cosmetics safely, effectively and easily absorbed.

A plant extract composition characterized by: comprises agave extract and a second component: one or more of glycerol, 1, 3-propanediol, 1, 2-propanediol, 1, 3-butanediol, 1, 2-pentanediol, methylpropanediol, 1, 2-hexanediol, 1, 2-octanediol, 1, 2-decanediol, 1, 5-pentanediol, 1, 6-hexanediol, 1, 8-octanediol and 1, 2-decanediol, wherein the weight ratio of the agave stem extract to the second component is 1:99 to 99: 1.

The second component is selected from: one or more of glycerol, 1, 3-propanediol, 1, 2-propanediol, 1, 3-butanediol and 1, 2-pentanediol, wherein the weight ratio of the agave extract to the second component is 30:70 to 70: 30.

The second component is 1, 3-propylene glycol, and the weight ratio of the agave extract to the second component is 60: 40.

A personal care product comprises an effective amount of the plant extract composition.

Preferably: contains 0.01 to 99 weight percent of plant extract composition.

Wherein the content of the plant extract composition is 1% to 20%.

Wherein the content of the plant extract composition is 10%.

The application of the agave extract or the plant extract composition in preparing the personal care product for external use and relieving itching and moisturizing.

The care product is a personal skin care product and a personal washing product.

According to the present invention, the term "agave extract" refers to an extract containing an active ingredient extracted from agave by any suitable means.

In the invention, the agave extract can generate obvious skin itching relieving and moisturizing effects. Meanwhile, the second component can generate a synergistic effect so as to improve the itching relieving and moisturizing effects of the composition. For example, the two compositions produce an effect that exceeds the effect expected of the agave extract and the second component when used alone.

The second component contained in the agave extract composition is one or more of glycerol, 1, 3-propanediol, 1, 2-propanediol, 1, 3-butanediol, sorbitol, 1, 2-pentanediol, methylpropanediol, 1, 2-hexanediol, 1, 2-octanediol, 1, 2-decanediol, 1, 5-pentanediol, 1, 6-hexanediol, 1, 8-octanediol, and 1, 2-decanediol. Preferably, the second component is selected from: one or more of glycerol, 1, 3-propylene glycol, 1, 2-propylene glycol, 1, 3-butanediol and 1, 2-pentanediol. In embodiments provided herein, the second component is optimally selected from: 1, 3-propanediol.

In the agave extract composition, the ratio of the agave extract to the second component is 1:99 to 99: 1. Preferably, the ratio of agave extract to the second component is from 30:70 to 70: 30. In embodiments provided herein, the second component is 1, 3-propanediol, preferably in a 60:40 ratio.

Another embodiment of the present invention relates to a personal skin care composition or a personal cleansing composition, which is appropriately selected depending on the usage, dosage form, age, sex, symptom, itching, dryness and the like of a subject to be administered, and which comprises 0.01 to 99% of the plant extract composition according to claim 1, wherein when the amount to be mixed is less than 0.01% based on the total amount of the composition, the effect of the present invention cannot be exerted, and no improvement in the effect is observed even when the amount exceeds 99%. Preferably, the agave extract composition is added in an amount of 1% to 20% in the personal care composition or the cleansing composition. In an embodiment provided herein, the optimal amount of agave extract composition added is 10%.

The personal skin care compositions or personal cleansing compositions described herein may be those described elsewhere in this specification or known to those of skill in the art. Non-limiting examples of products include moisturizers, moisturizing creams, sunscreens, lotions, foundations, night creams, shampoos, body washes, facial masks. Furthermore, the personal skin care composition or personal cleansing composition may be formulated as a leave-on or rinse-off product. These forms of personal skin care compositions and personal cleansing compositions can be prepared by methods well known to those skilled in the art.

The personal skin care compositions or personal cleansing compositions of the present invention may include other beneficial agents and compounds such as oils, waxes, sunscreens, moisturizers, antioxidants, emulsifiers, preservatives, thickeners and the like.

Non-limiting oils that may be used in combination with the compositions of the present invention include: phytosterol isostearate, neopentyl glycol diheptanoate, hydrogenated coconut oil glycerides, hydrogenated methyl rosinate, hydrogenated polyprenol, caprylic/capric triglyceride, ethyl hexanol palmitate, sucrose acetate isobutyrate, butyl stearate, propylene glycol dibenzoate, polymethylsiloxane, octyldodecanol, isoparaffin, petrolatum, isooctyl palmitate, vegetable lanolin, castor oil, hydrogenated castor oil, lecithin, hydrogenated lecithin, evening primrose oil, sweet almond oil, wheat germ oil, avocado oil, grape seed oil, jojoba oil, calendula oil, rapeseed oil, lavender oil, chamomile oil, clary sage oil, sunflower seed oil, cocoa butter, corn oil, peppermint oil, coconut oil caprylate/caprate, cholesterol hydroxystearate, propylene glycol dicaprylate/dicaprate, glycerin, hydrogenated palm oil/capric triglyceride, ethyl hexanoate, sucrose acetate isobutyrate, butyl stearate, propylene glycol dibenzoate, methyl palmitate, hydrogenated polydecamomile, hydrogenated polysufol, hydrogenated palm oil/capric acid triglyceride, hydrogenated castor oil, hydrogenated lecithin, hydrogenated soybean oil, hydrogenated, Rice bran oil, rosemary oil, sage oil and squalane.

Non-limiting waxes that may be used in combination with the compositions of the present invention include: natural beeswax, synthetic beeswax, sugar cane wax, candelilla wax, carnauba wax, ozokerite, paraffin wax.

Non-limiting sunscreens which may be used in combination with the compositions of the present invention include chemical and physical sunscreens. Non-limiting examples of chemical sunscreens that may be used include: benzophenone-3, benzophenone-4, ethylhexyl salicylate, ethylhexyl methoxycinnamate, butyl methoxydibenzoylmethane, octocrylene, ethylhexyl triazone, isoamyl p-dimethylaminobenzoate, isooctyl p-dimethylaminobenzoate, butyl p-aminobenzoate. Non-limiting examples of physical sunscreens that may be used include: zinc oxide, titanium dioxide.

Non-limiting examples of humectants that can be used in combination with the compositions of the present invention include: sodium hyaluronate, trehalose, erythritol, glycosyl trehalose/hydrogenated starch hydrolysate, biogan-1, hydrolyzed corn starch, acetyl chitosamine, Aureobasidium pullulans, oat beta-glucan, sodium polyglutamate, pyrrolidone carboxylate, and Aloe barbadensis extract.

Non-limiting examples of antioxidants that can be used in combination with the compositions of the present invention include: 3-o-ethyl ascorbic acid, ascorbyl palmitate, superoxide dismutase, BHA, BHT, grape seed extract, green tea extract, sodium metabisulfite, tocopherol, tocopheryl acetate.

In some aspects of the invention, the composition does not include an emulsifier. However, in other aspects, the composition includes one or more emulsifiers. Emulsifiers, which may be nonionic, cationic, anionic and zwitterionic emulsifiers, are capable of reducing interfacial tension between phases and improving the stability of the formulation. Non-limiting examples include: sucrose stearate, sodium stearyl lactylate, polyethylene glycol fatty acid esters, sorbitan anhydride esters, polyoxyethylene fatty ether phosphate, TEA stearate, and mixtures thereof.

Non-limiting examples of preservatives that may be used in combination with the compositions of the present invention include: p-hydroxyacetophenone, phenoxyethanol, parabens, sorbic acid, triclosan, chlorhexidine and other classes of compounds listed in cosmetic hygiene specifications.

Non-limiting examples of thickeners that may be used in combination with the compositions of the present invention include: sodium polyacrylate/C13-14 isoparaffin/trideceth-6, polyacrylic acid, xanthan gum, carboxymethylcellulose, hydroxyethylcellulose, polyethylene glycol mono-and diesters, fatty alcohol ethoxylates.

Experiments show that the maguey extract which is naturally extracted or the maguey extract which is matched with the second composition has the effects of obviously improving the skin pruritus and moisturizing.

Drawings

FIG. 1 shows the antipruritic effect of the Agave extract and different second components,

figure 2 moisturizing effect of agave extract and different second components,

FIG. 3 shows the antipruritic effect of 1, 3-propanediol with different contents,

FIG. 4 shows the moisturizing effect of different amounts of 1, 3-propanediol,

figure 5 antipruritic effect of different amounts of the composition in personal skin care,

figure 6 moisturizing effect of different amounts of compositions in personal skin care,

figure 7 shows the antipruritic effect of different amounts of the composition in the personal cleansing product,

figure 8 moisturizing effect of different amounts of the composition in the personal cleansing product.

Detailed Description

Hereinafter, preferred embodiments and comparative examples are disclosed for the understanding of the present invention. However, the following examples are provided for easier understanding of the present invention, and the scope of the present invention is not limited to the following examples.

The efficacy of the compositions of the present invention can be determined by methods known to those of ordinary skill in the art. The following are non-limiting embodiments that can be used in the present invention. It will be appreciated that other verification schemes may be used, including, for example, objective and subjective schemes.

Examples 1 to 5 and comparative examples 1 to 6

In this example, the selection of the second component of the agave extract and composition of the present invention, the activity of which in suppressing skin itch and moisturizing, was confirmed by the following assay.

Test for antipruritic Effect

Guinea pigs were then divided into 2 groups of 10 animals each, and the control group was combined with the examples. One day prior to the experiment, the right hind instep of each group of guinea pigs was painted with a sample. On the day of experiment, the shaved part of the right hind paw of the animal was abraded with coarse sandpaper to about 1cm²And the sample is smeared at the position once. After 10min, 0.01% histamine phosphate 0.5 mL/body is dripped on the wound surface, and the concentration is increased by 0.01%, 0.02%, 0.03%, 0.04%. the.

Test of moisturizing Effect

Skin moisture content was measured using a Nova Dermal Phase Meter skin moisture tester. The instrument reflects changes in skin moisture content by measuring skin impedance: the outer layer of skin has different electrical properties and conducts electricity poorly when the skin is dry. As its moisture content increases, the conductivity increases and, as a result, the skin impedance changes (related to conductivity) and can be used to assess changes in skin hydration.

10 subjects with moderately dry skin were selected, with an average age of 32.8 years, and within the washout period of 1 week prior to the test, were asked to have a normal bath, but not to have any moisturizing product applied to the forearms of both hands after bathing. Smearing test samples on the forearm test parts of both hands of a subject in the morning and evening after the start of the experimentThe coating amount is 2mg/cm²And (4) calculating. And measuring the stratum corneum moisture growth rate of the tested part of the tested subject by adopting a skin moisture tester at 2 weeks.

As shown in fig. 1 to 2, it can be seen from the test results that the agave extract has the effect of improving skin itch and moisturizing, and has the best effect on improving skin itch and moisturizing when the second component is 1, 3-propanediol.

Examples 7 to 11

Composition (I)	Example 7	Example 8	Example 9	Example 10	Example 11
						Agave extract (%)	70	60	50	40	30
1, 3-propanediol (%)	30	40	50	60	70

In this example, it was confirmed that the optimum ratio of the agave extract to the second component 1, 3-propanediol in the agave extract composition of the present invention was improved in skin itch and moisturizing effect by the following analysis.

Examples 7 to 11 antipruritic effects (test methods same as above)

Examples 7 to 11 moisturizing effect (test methods same as above)

As shown in fig. 3 to 4, it can be seen from the test results that the ratio of agave extract to 1, 3-propanediol is 60:40, which has the best effect on the improvement aspect of skin itch and moisturizing property.

Examples 12-15 personal skin Care compositions

Preparation of personal skin care compositions: add the ingredients of phase a to the beaker and heat to 70-75 ℃ while mixing. Subsequently, the ingredients of phase B were heated to 70-75 ℃ while mixing. Slowly pouring the phase B into the phase A, and homogenizing. Cooling the mixture to 40 ℃, slowly adding the phase C and the phase D under the stirring state, and uniformly stirring.

Examples 12 to 15 antipruritic effect test (test methods same as above)

Examples 12 to 15 test for moisturizing Effect (test methods same as above)

As shown in fig. 5 to 6, it can be seen from the test results that the agave extract composition has the best effect on the improvement of skin itch and moisturizing property at the addition ratio of 10% in the personal care products.

Examples 16-19 personal cleansing compositions

Preparation of personal cleansing composition: heating the component A to about 85 deg.C until it is completely dissolved, adding the component B, stirring, cooling to about 55 deg.C, adding the component C, stirring, adding the component D, and stirring.

Examples 16 to 19 test for antipruritic effect (the same test methods as above)

Examples 16 to 19 test for moisturizing Effect (test methods same as above)

As shown in fig. 4, it can be seen from the test results that the agave extract composition has the best effect on the improvement of skin itch and moisturizing property at the addition ratio of 10% in the personal cleansing composition.

The agave extract composition has good effects of improving skin itch and moisturizing, and is effective in treating skin itch and moisturizing. The agave extract composition of the present invention can be easily formulated into personal skin care products and personal cleansing compositions for daily use by mixing various materials as other ingredients than the active ingredient.

Claims

1. The application of the plant extract composition in preparing the external itching-relieving and moisturizing care product comprises the agave extract and a second component, wherein the second component is 1, 3-propylene glycol, and the weight ratio of the agave extract to the second component is 60: 40.

2. Use according to claim 1, the care products being personal skin care products and personal washing products.

3. The use according to claim 2, wherein the skin care product is a personal skin care product comprising from 0.01% to 99% by weight of the plant extract composition.

4. Use according to claim 3, wherein the content of the plant extract composition is between 1% and 20%.

5. The use according to claim 4, wherein the plant extract composition is present in an amount of 10%.