CN107898658A - 六胜肽祛皱增效原液组合物 - Google Patents
六胜肽祛皱增效原液组合物 Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 12
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 title claims abstract 9
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 title claims abstract 9
- 102000019197 Superoxide Dismutase Human genes 0.000 claims abstract description 12
- 108010012715 Superoxide dismutase Proteins 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims abstract description 9
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008367 deionised water Substances 0.000 claims abstract description 9
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 9
- 239000004474 valine Substances 0.000 claims abstract description 9
- 239000004475 Arginine Substances 0.000 claims abstract description 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract 7
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract 7
- 229920002521 macromolecule Polymers 0.000 claims abstract 3
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims abstract 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 abstract description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical class CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 18
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 11
- 229920002674 hyaluronan Polymers 0.000 description 11
- 229960003160 hyaluronic acid Drugs 0.000 description 11
- 239000011550 stock solution Substances 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 3
- 230000003712 anti-aging effect Effects 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004118 muscle contraction Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- -1 1.3- Butylene glycol Chemical compound 0.000 description 1
- 108030001720 Bontoxilysin Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 229940053031 botulinum toxin Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
一种六胜肽祛皱增效原液组合物,由以下重量百分比的原料组成,六胜肽‑8 0.01‑0.02%、高分子玻尿酸0.15‑0.25%、低分子玻尿酸0.1‑0.15%、超氧物歧化酶0.02‑0.04%、精氨酸0.01‑0.02%、缬氨酸0.01‑0.02%、1.3‑丁二醇0.5‑1.0%、丙二醇3.0‑5.0%、余量为去离子水。本发明的六胜肽祛皱增效原液组合物,通过将六胜肽‑8与氨基酸、玻尿酸,超氧物歧化酶等有机的结合,使之具有更加合适的等电点充分发挥六胜肽的祛皱功效、保湿功效、控制皮肤的水油平衡和抗衰老功能。
Description
技术领域
本发明属于化妆品领域,具体涉及一种六胜肽祛皱增效原液组合物。
背景技术
随着人们年龄自然老化,皮肤的视觉外观、物理特性和生理功能发生变化,人体内成纤维细胞的数量逐渐减少,因此其分泌的胶原蛋白和弹力纤维蛋白也因为被氧化逐渐减少、断裂,真皮层开始变薄,皮肤弹性变差,皱纹也开始逐渐产生。
六胜肽是由六个氨基酸排列组合而成的生化产品,是一种类肉毒素成分,具有肉毒素全部功能,而不含任何毒性,是非毒性物质。六胜肽具有可拦截肌肉收缩的信号,减轻肌肉收缩的力道,进而改善细纹的深度和长度,用于抗皱成分,效果较好。但目前市场六胜肽原液效果单一,很难找到一种保湿效果好且能够紧致肌肤,消除细纹的产品。
发明内容
本发明的目的就是提供一种保湿效果好,能够紧致肌肤,消除皮肤细纹的六胜肽祛皱增效原液组合物。
本发明的六胜肽祛皱增效原液组合物,由以下重量百分比的原料组成,六胜肽-80.01-0.02%、高分子玻尿酸0.15-0.25%、低分子玻尿酸0.1-0.15%、超氧物歧化酶0.02-0.04%、精氨酸0.01-0.02%、缬氨酸0.01-0.02%、1.3-丁二醇0.5-1.0%、丙二醇3.0-5.0%、余量为去离子水。
本发明的六胜肽祛皱增效原液组合物制备方法是,按配比将六胜肽-8、高分子玻尿酸、低分子玻尿酸、超氧物歧化酶、精氨酸、缬氨酸、1.3-丁二醇、丙二醇、余量为去离子水,搅拌混合灌装即可。
本发明的六胜肽祛皱增效原液组合物,通过将六胜肽-8与氨基酸、玻尿酸,超氧物歧化酶(Superoxide dismutase简称SOD)等有机的结合,使之具有更加合适的等电点充分发挥六胜肽的祛皱功效、保湿功效、控制皮肤的水油平衡和抗衰老功能。
具体实施方式
实施例1
一种脸部外用具有祛皱、保湿、控制皮肤的水油平衡、抗衰老功能的原液组合物由以下重量百分比原料组成:六胜肽-8 0.01%、高分子玻尿酸0.20%、低分子玻尿酸0.15%、超氧物歧化酶0.02%、精氨酸0.01%、缬氨酸0.02%、1.3-丁二醇0.6%、丙二醇3.0%,余量为去离子水。
其制备方法是:按配比将六胜肽-8、高分子玻尿酸、低分子玻尿酸、超氧物歧化酶、精氨酸、缬氨酸、1.3-丁二醇、丙二醇、余量为去离子水,搅拌混合灌装。
实施例2
一种脸部外用具有祛皱、保湿、控制皮肤的水油平衡、抗衰老功能的原液组合物由以下重量百分比原料组成:六胜肽-80.02%、高分子玻尿酸0.25%,低分子玻尿酸0.1%,超氧物歧化酶0.04%,精氨酸0.02%、缬氨酸0.01%,1.3-丁二醇0.8%,丙二醇5.0%,余量为去离子水。
其制备方法是:按配比将六胜肽-8、高分子玻尿酸、低分子玻尿酸、超氧物歧化酶、精氨酸、缬氨酸、1.3-丁二醇、丙二醇、余量为去离子水,搅拌混合灌装。
Claims (1)
1.一种六胜肽祛皱增效原液组合物,其特征在于:它是由以下重量百分比的原料组成,六胜肽-8 0.01-0.02%、高分子玻尿酸0.15-0.25%、低分子玻尿酸0.1-0.15%、超氧物歧化酶0.02-0.04%、精氨酸0.01-0.02%、缬氨酸0.01-0.02%、1.3-丁二醇0.5-1.0%、丙二醇3.0-5.0%、余量为去离子水;
其制备方法是,按配比将六胜肽-8、高分子玻尿酸、低分子玻尿酸、超氧物歧化酶、精氨酸、缬氨酸、1.3-丁二醇、丙二醇、余量为去离子水,搅拌混合灌装即可。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110151585A (zh) * | 2019-07-04 | 2019-08-23 | 广东天源生物科技有限公司 | 一种具有美白淡化痘印性能寡肽原液及其制备方法 |
CN111012729A (zh) * | 2020-01-13 | 2020-04-17 | 南京平港健康管理有限公司 | 一种玻尿酸抗皱原液 |
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CN101214200A (zh) * | 2008-01-21 | 2008-07-09 | 丁克祥 | 皮肤外用液态和固态类肉毒素(六胜肽)复合纳米乳及其制备方法 |
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CN104983666A (zh) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | 修复再生面膜产品及其制备方法 |
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CN106344427A (zh) * | 2016-10-13 | 2017-01-25 | 珠海美逸生物科技有限公司 | 用于面部护理的多肽复合物及其制备方法 |
CN107308020A (zh) * | 2017-07-06 | 2017-11-03 | 珠海联邦制药股份有限公司 | 一种稳定的多肽组合物及其应用 |
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2017
- 2017-12-13 CN CN201711331041.9A patent/CN107898658A/zh active Pending
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CN101214200A (zh) * | 2008-01-21 | 2008-07-09 | 丁克祥 | 皮肤外用液态和固态类肉毒素(六胜肽)复合纳米乳及其制备方法 |
CN102015764A (zh) * | 2008-02-29 | 2011-04-13 | 利普泰股份公司 | 包含金属蛋白酶抑制剂的化妆品组合物或药物组合物 |
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CN104207977A (zh) * | 2014-08-21 | 2014-12-17 | 广州市美立方化妆品有限公司 | 一种活性肽抗衰祛皱镇敏精华液及其制备方法 |
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CN106344427A (zh) * | 2016-10-13 | 2017-01-25 | 珠海美逸生物科技有限公司 | 用于面部护理的多肽复合物及其制备方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110151585A (zh) * | 2019-07-04 | 2019-08-23 | 广东天源生物科技有限公司 | 一种具有美白淡化痘印性能寡肽原液及其制备方法 |
CN111012729A (zh) * | 2020-01-13 | 2020-04-17 | 南京平港健康管理有限公司 | 一种玻尿酸抗皱原液 |
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