CN107854562A - A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription - Google Patents
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription Download PDFInfo
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Abstract
The invention discloses a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, including component A, B component, component A to include raw material：Saline cistanche, barrenwort, Semen Cuscutae, the fruit of Chinese magnoliavine, spongilla, radix glycyrrhizae, annex solution；B component includes raw material：Cynomorium songaricum, Poria cocos, prepared rhizome of rehmannia, the bighead atractylodes rhizome, moutan bark, Fructus Corni, supplement powder.Compared with prior art, the cure rate for the treatment of by Chinese herbs male's Patients with Kidney Deficiency Type of the invention and total effective rate are significantly higher than the cure rate of drug therapy male Patients with Kidney Deficiency Type and total effective rate made from prior art, and recurrence rate is low.
Description
【Technical field】
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription.
【Background technology】
At present, the live and work rhythm of people is substantially accelerated, and is busy with one's work, and the pressure born is increasing, lacks
Constitution is taken exercise, and many people especially men's health level is on a declining curve year by year, and kidney deficiency, insufficiency of vital energy and blood etc. occurs, so as to lead
The generation of many diseases is caused, such as physically weak alopecia, has a dizzy spell, have a pain in the back, dysphoria with smothery sensation of having a sleepless night illness, and it is impotence and premature ejaculation, preceding
The sexual disorders such as row gland disease.Due to relevant knowledge shortage or idea constraint, many people are ashamed of medical treatment and voluntarily abuse of market
Upper various excitants, not only accelerate body health level decrease speed, it is also possible to induce other serious diseases.Doctor trained in Western medicine circle often uses
Glucocorticoid treatment kidney trouble, the pain of patient is alleviated to a certain extent, the effect of improving in a short time.But milli
Uncontrolled hormone application, patient is set various irreversible serious symptoms occur, such as：The sugared cortex of long-term super physiological dose
Hormone application can cause water, salt, sugar, protein and fat metabolic disturbance, class adrenocortical hyperfunction occur.Show as
Central obesity, calcium uptake obstacle is caused, cause osteoporosis, severe patient also may occur from hair property fracture.Middle medical circles' treatment is more
With kidney tonifying medicine, but produce little effect.
The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, and built-in nephroyin and nephroyang, kidney deficiency divides kidney-yin deficiency and kidney-yang deficiency, be according to different diseases
Shape does Coryza Treated by Syndrome Differentiation.Kidney deficiency is mostly that long-term bad habits and customs accumulation forms, and blindly can't disorderly enter tonic, or use composition
Not clear tonifying kidney and strengthening yang medicine.Kidney deficiency is with pain in the back with based on aching and limp, and dizziness and tinnitus, desire for being robbed and pressed, leg knee is powerless, meets labor more very,
It is sleeping then mitigate, normal recurrent exerbation.The Western medicine with the gentle physical fatigue of tonifying kidney and strengthening yang sell in the market or common
Cure the symptoms, not the disease, and side effect is larger, unobvious the effect of Chinese patent drug, and health food permanence operation it is bad and expend compared with
It is high.
【The content of the invention】
The technical problem to be solved in the present invention is to provide a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, to solve to treat the treatment of kidney deficiency
Imitate that the time is long, side effect is big and drug effect is low, the problem of high recurrence rate.
In order to solve the above technical problems, the present invention uses following technical scheme：
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and the component A includes pressing as follows
The raw material of parts by weight meter：
60~65 portions of saline cistanches
30~35 parts of barrenwort
25~28 portions of Semen Cuscutaes
18~23 portions of fruit ofs Chinese magnoliavine
15~20 parts of spongillas
13~16 portions of radix glycyrrhizaes
6~7 parts of annex solutions；
The B component includes the following raw material counted in parts by weight：
50~55 parts of cynomorium songaricums
40~45 parts of Poria cocos
36~42 parts of prepared rhizomes of rehmannia
32~35 parts of bighead atractylodes rhizomes
22~26 parts of moutan barks
14~17 portions of Fructus Cornis
10~12 parts of supplement powder.
Preferably, the preparation method of annex solution comprises the following steps：
(1) in mass ratio 2~4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, is received
Collect crushed mixture, be placed in standing 3~6h at 35~40 DEG C；
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and
Concentrated, be concentrated into the 50~55% of extract volume, collected concentrate, sterilizing, produce annex solution.
Preferably, the preparation method for augmenting powder comprises the following steps：
A. in mass ratio 12:4~6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture
With 0.5mol/L sodium chloride solutions in mass ratio 1:4~6 are put into digester and carry out boiling, collect cooking mixture；
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected
Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
The invention has the advantages that：
(1) from embodiment 1-3 data, embodiment 2 is optimum embodiment, and the fully recovering of acquisition, total efficiently individual quantity are most
It is more.
(2) from the data of embodiment 1-3 and comparative example 1~15 and comparative example 16, in component A, B component and each component
Raw material serve synergy in male's nephrosis Chinese medicine is prepared, controlled using the traditional Chinese medicine for invigorating kidney and strengthening yang prescription for preparing of the present invention
It is good to treat the effect of male's Patients with Kidney Deficiency Type of the significant effect drug therapy more commercially available than comparative example 16 of male's Patients with Kidney Deficiency Type, and without pair
Effect.
(3) traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the invention is thoroughly effected a radical cure by oral administration and externally to Patients with Kidney Deficiency Type, first
By being warmed to human body three acupuncture point Guanyuan points, Zusanli, point Fengfus, these three acupuncture points are distributed in the upper, middle and lower of human body,
The circulation of blood can be effectively facilitated, the capillary at acupuncture point opens in Warming processes, utilizes saline cistanche, excessive sheep in component A
The Chinese herbal medicines such as the leaves of pulse plants, Semen Cuscutae carry out fermentation extraction, and the macromolecular in Chinese herbal medicine is changed into small molecule by the effect of microorganism,
Nursed one's health, the beneficiating ingredient of kidney tonifying, improve human body and it is absorbed, by the absorption at acupuncture point, so as to promote blood to follow
Ring, human mechanism is nursed one's health using blood circulation, and nourishing is carried out to human body using the nutriment in annex solution and is supported
Point, and directly act on kidney by channels and collaterals, play the solid member of kidney tonifying, the effect of warming kidney and enhancing body, while improve blood circulation
Also absorption of the human body to material can be increased, then drink B component, because early stage uses component A, improve human body to B component
Absorb and utilize, inside of human body system is nursed one's health by the material in B component, keep inside of human body system stable, then profit
Human body kidney is further nourished with the material such as ripe, glutinous rehmannia of cynomorium songaricum, Poria cocos in B component, and using nutriment to kidney
It is dirty to be nourished, during preventing nourishing, can not supplying in time for nutriment, keep the vigor of kidney.
【Embodiment】
For ease of more fully understanding the present invention, it is illustrated by following instance, these examples belong to the protection of the present invention
Scope, but do not limit the scope of the invention.
In embodiment, the preparation method of annex solution comprises the following steps：
(1) in mass ratio 2~4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, is received
Collect crushed mixture, be placed in standing 3~6h at 35~40 DEG C；
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and
Concentrated, be concentrated into the 50~55% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps：
A. in mass ratio 12:4~6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture
With 0.5mol/L sodium chloride solutions in mass ratio 1:4~6 are put into digester and carry out boiling, collect cooking mixture；
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected
Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and the component A includes pressing as follows
The raw material of parts by weight meter：
60~65 portions of saline cistanches
30~35 parts of barrenwort
25~28 portions of Semen Cuscutaes
18~23 portions of fruit ofs Chinese magnoliavine
15~20 parts of spongillas
13~16 portions of radix glycyrrhizaes
6~7 parts of annex solutions；
The B component includes the following raw material counted in parts by weight：
50~55 parts of cynomorium songaricums
40~45 parts of Poria cocos
36~42 parts of prepared rhizomes of rehmannia
32~35 parts of bighead atractylodes rhizomes
22~26 parts of moutan barks
14~17 portions of Fructus Cornis
10~12 parts of supplement powder.
The preparation process of component A is in the present invention：
S1. meter carries out taking raw material in parts by weight, is put into ball mill with 800r/min ball milling 40min, collects ball milling and mixes
Compound, by ball-milled mixtures and water in mass ratio 1:3 mixing, are put into container, the boiling 50min at 100 DEG C；
S2. after boiling terminates, naturally cool to room temperature, collect cooking mixture, in mass ratio 8:1, boiling is mixed
Thing mixes with the bent essence of aspergillus oryzae, is fermented 3 days at 38 DEG C, collects fermenting mixture, filtered, collected filtrate, be concentrated into filter
The 50% of liquid product, collects concentrate, sterilizing, produces component A.
The preparation process of B component is in the present invention：
D1. meter is carried out taking raw material in parts by weight, and raw material is put into 60 DEG C of baking ovens and dry, pulverize, and crosses 200 mesh sieves, is received
Collection sieving particle；
D2. will sieving particle and 1.6mol/L ethanol solutions in mass ratio 1:3 mixing, carry out steam blasting, collect explosion
Mixture, then supercritical carbon dioxide extracting is carried out, extract is collected, is centrifuged, collects supernatant, is distilled to recover ethanol,
Residue is collected, produces B component.
Below by more specific embodiment, the present invention will be described.
Embodiment 1
The preparation method of annex solution comprises the following steps：
(1) in mass ratio 4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder
Broken mixture, it is placed in standing 6h at 40 DEG C；
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and
Concentrated, be concentrated into the 55% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps：
A. in mass ratio 12:6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with
0.5mol/L sodium chloride solutions in mass ratio 1:6 are put into digester and carry out boiling, collect cooking mixture；
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected
Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and component A is included as follows by weight
The raw material of number meter：
65 portions of saline cistanches
35 parts of barrenwort
28 portions of Semen Cuscutaes
23 portions of fruit ofs Chinese magnoliavine
20 parts of spongillas
16 portions of radix glycyrrhizaes
7 parts of annex solutions；
The B component includes the following raw material counted in parts by weight：
55 parts of cynomorium songaricums
45 parts of Poria cocos
42 parts of prepared rhizomes of rehmannia
35 parts of bighead atractylodes rhizomes
26 parts of moutan barks
17 portions of Fructus Cornis
12 parts of supplement powder.
Embodiment 2
The preparation method of annex solution comprises the following steps：
(1) in mass ratio 3:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder
Broken mixture, it is placed in standing 5h at 38 DEG C；
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and
Concentrated, be concentrated into the 53% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps：
A. in mass ratio 12:5:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with
0.5mol/L sodium chloride solutions in mass ratio 1:5 are put into digester and carry out boiling, collect cooking mixture；
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected
Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and component A is included as follows by weight
The raw material of number meter：
64 portions of saline cistanches
33 parts of barrenwort
27 portions of Semen Cuscutaes
20 portions of fruit ofs Chinese magnoliavine
18 parts of spongillas
15 portions of radix glycyrrhizaes
6.5 parts of annex solutions；
The B component includes the following raw material counted in parts by weight：
53 parts of cynomorium songaricums
42 parts of Poria cocos
40 parts of prepared rhizomes of rehmannia
33 parts of bighead atractylodes rhizomes
24 parts of moutan barks
15 portions of Fructus Cornis
11 parts of supplement powder.
Embodiment 3
The preparation method of annex solution comprises the following steps：
(1) in mass ratio 2:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder
Broken mixture, it is placed in standing 3h at 35 DEG C；
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and
Concentrated, be concentrated into the 50% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps：
A. in mass ratio 12:4:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with
0.5mol/L sodium chloride solutions in mass ratio 1:4 are put into digester and carry out boiling, collect cooking mixture；
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected
Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and component A is included as follows by weight
The raw material of number meter：
60 portions of saline cistanches
30 parts of barrenwort
25 portions of Semen Cuscutaes
18 portions of fruit ofs Chinese magnoliavine
15 parts of spongillas
13 portions of radix glycyrrhizaes
6 parts of annex solutions；
The B component includes the following raw material counted in parts by weight：
50 parts of cynomorium songaricums
40 parts of Poria cocos
36 parts of prepared rhizomes of rehmannia
32 parts of bighead atractylodes rhizomes
22 parts of moutan barks
14 portions of Fructus Cornis
10 parts of supplement powder.
Comparative example 1
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no B groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription
Part.
Comparative example 2
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no A groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription
Part.
Comparative example 3
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no B groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription
Part, and there is no annex solution in component A.
Comparative example 4
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription in component A
There is annex solution.
Comparative example 5
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no A groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription
Part, and without supplement powder in B component.
Comparative example 6
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription in B component
There is supplement powder.
Comparative example 7
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription B component
Cynomorium songaricum.
Comparative example 8
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
Saline cistanche.
Comparative example 9
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
Barrenwort.
Comparative example 10
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
Semen Cuscutae.
Comparative example 11
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
The fruit of Chinese magnoliavine.
Comparative example 12
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
Spongilla.
Comparative example 13
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
Radix glycyrrhizae.
Comparative example 14
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
Poria cocos.
Comparative example 15
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A
Prepared rhizome of rehmannia.
The commercially available tonifying kidney and strengthening yang medicine of comparative example 16.
Pharmacology pharmacodynamic is tested：
1. acute toxicity test
Application mouse carries out acute toxicity testing and shown：Mouse oral gavage embodiment of the present invention 1-3 Chinese medicine,
Under 488.8g crude drugs/kg dosage, there is light activity reduction, 1h or so recovery normally in mouse after administration, Continuous Observation 7 after administration
My god, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight increase normal, test result indicates that：Mouse mouth
The maximum dosage-feeding for taking gavage embodiment 1-3 Chinese medicine is 488.8g crude drugs/kg/d (LD50 ＞ 488.8g crude drugs/kg).This hair
The bright embodiment 1-3 daily clinical application total amount of Chinese medicine is 0.1g crude drugs/kg/d；By batheroom scale, in the mouse stomach present invention
The dosis tolerata of medicine preparation is 4888 times of clinical patient.Prompt the medicine acute toxicity low, clinical application safety.
2. long term toxicity test
From SD rats, the 1-3 of the embodiment of the present invention of various concentrations (18.0,6.0,2.0g crude drugs/kg) Chinese medicine is given,
Daily gavage once, continuous 90 days, lived and kill 1/2 animal (male and female half and half) after last dose, and remaining 1/2 animal continues by 24h each groups
Work is killed after observing 2 weeks.Outward appearance, general behavior, food ration, the changes of weight of animal are observed during experiment, 90 days and is stopped after administration
Medicine 2 weeks carry out hematologies (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP,
Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checking such as Histopathology.Experiment knot
Fruit shows：Chinese medicine of the present invention is good in high, medium and low dosage group animal general state, appearance sign, behavioral activity, food-intake and
Body weight increase change without exception；Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis exist
Normal range (NR), without significant difference between group；Each group main organs histopathological examination is shown no obvious abnormalities.These parameters drug withdrawal 2
Also change is had no after week.This experiment dosage is respectively the 180 of clinical medicine dose, 60,20 times, according to this hair of result of the test
Bright Chinese medicine preparation is in high, medium and low three dosage (18.0,6.0,2.0g crude drugs/kg) administration in continuous 90 days to rat without obvious
Influence, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, prompts the present invention's
The dose safety of Chinese medicine preparation clinical practice is higher.
3. animal local excitation is tested：
The allergic reaction on guinea pigs and Rat-rectum medication irritation test of 1-3 of embodiment of the present invention Chinese medicine.As a result
Show：Skin anaphylactic test, high dose group 0.8g (medicinal powder)/kg, low dose group 0.1g (medicinal powder)/kg, is respectively equivalent to plan and faces
20 times, 2.5 times of bed people's dosage [0.04g (medicinal powder)/kg], through percutaneous drug delivery, it is showed no animal and produces allergy；Rectum is used
Medicine irritation test high dose group 5.0g (medicinal powder)/kg, low dose group 3.2g (medicinal powder)/kg, it is respectively equivalent to intend clinical people's use
125,80 times of amount, phenomena such as mucous membrane of rectum is without hyperemia, oedema, histopathologic examination and sky are observed within the defined time
White control group compares no significant difference, has no obvious irritative response occur, its overall health of patients of the Some Animals of every group of retention,
Body weight, breathing, circulation, central nervous system and four limbs activity etc., equal Non Apparent Abnormality reaction.
The illness of traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the present invention is applicable, its clinical manifestation symptom：Deficiency of qi and blood, the insufficiency of the kidney yang,
Have a delicate constitution, the disease such as impotence and premature ejaculation.
Diagnostic criteria：It is strict by the clinical drug demonstration plan for treating impotence kidney deficiency according to tcm treatment according to syndrome differentiation principle
The standard diagnostics of such disease, the relevant Chinese medicine clinical research principle developed and published according to the Ministry of Public Health, therapeutic effect is divided into and fullyed recover from an illness
More, invalid and total effective rate is judged.
The application method of traditional Chinese medicine for invigorating kidney and strengthening yang prescription：Once in the morning and once at night, use in the morning after meal, makes before sleeping at night
With, first using component A, B component is reused, it is warm to Guanyuan point, Zusanli, point Fengfu progress first by 40~45 DEG C of warm water
5~10min of heat, rubbing 1min is carried out to Guanyuan point, Zusanli, point Fengfu using component A, then takes B component, each taking
Measure as 15mL.
The clinical efficacy of 1-3 of the embodiment of the present invention and comparative example 1-8 treatment by Chinese herbs male's kidney deficiency is investigated, selects 160
Clinical observation on the therapeutic effect is carried out using the male of illness of the present invention, 8 groups is randomly divided into, every group 20, tracking treatment 1 month, continues
Track 1 year, observe recurrence rate, first group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of embodiment 1, second group uses implementation
The traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the present invention of example 2, the 3rd group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of embodiment 3, the
Four groups of traditional Chinese medicine for invigorating kidney and strengthening yang prescriptions using the present invention of comparative example 4, the 5th group of tonifying kidney and strengthening yang using the present invention of comparative example 5
Chinese prescription, the 6th group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of comparative example 6, the 7th group uses the present invention of comparative example 7
Traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the 8th group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of comparative example 8, the like, often
Traditional Chinese medicine for invigorating kidney and strengthening yang prescription in the corresponding corresponding comparative example of group, comparative example 16 use tonifying kidney and strengthening yang commercially available in comparative example 8
Medicine.
Therapeutic effect：
Observation of curative effect result see the table below.
As seen from the above table：(1) from embodiment 1-3 data, embodiment 2 is optimum embodiment, and acquisition is fully recovered, always
Efficiently individual quantity is most, and recurrence rate is minimum.
(2) from the data of embodiment 1-3 and comparative example 1~15 and comparative example 16, in component A, B component and each component
Raw material serve synergy in male's nephrosis Chinese medicine is prepared, controlled using the traditional Chinese medicine for invigorating kidney and strengthening yang prescription for preparing of the present invention
It is good to treat the effect of male's Patients with Kidney Deficiency Type of the significant effect drug therapy more commercially available than comparative example 16 of male's Patients with Kidney Deficiency Type, and without pair
Effect.
(3) from clinical data, component A, B component in the present invention serve collaboration in treatment improves male's kidney deficiency
Effect, significantly improve treatment the fully recovering of male's Patients with Kidney Deficiency Type, total efficiently individual quantity.The traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the present invention leads to
Cross oral administration and externally thoroughly to effect a radical cure Patients with Kidney Deficiency Type, first by entering human body three acupuncture point Guanyuan points, Zusanli, point Fengfus
Row warm, these three acupuncture points are distributed in the upper, middle and lower of human body, can effectively facilitate the circulation of blood, the acupuncture point in Warming processes
Capillary opens, and using the liquid for by fermentation extract preparation in component A, quickly can be absorbed by skin and acupuncture point,
By the absorption at acupuncture point, so as to stimulate circulation, human body is nursed one's health using blood circulation, uses the nutrition in annex solution
Material carries out nourishing nutrient to human body, and may also pass through channels and collaterals and directly act on kidney, plays the solid member of kidney tonifying, warming kidney and enhancing body
The effect of, while improve blood circulation and can also increase absorption of the human body to material, B component is then drunk, because early stage uses A groups
Part, absorption and utilization of the human body to B component are improved, inside of human body system is nursed one's health by the material in B component, is kept
Inside of human body system is stable, recycles establishing-Yang material to improve renal function, and kidney is nourished using nutriment, keeps
The vigor of kidney；While also in that：
1. saline cistanche：Kidney-replenishing, benefiting essence-blood, ease constipation road.Main decline of kidney-YANG, the impotence of asthenia of essence and blood, seminal emission.
2. barrenwort：Barrenwort acrid-sweet flavor is warm-natured, walks liver kidney two warp.To mend the gate of vitality, strengthening the essence gas, strengthening the bones and muscles, tonifying kidney and strengthening yang
Key medicine, clinic be usually used in treating impotence in male do not lift, the disease such as involuntary emission premature ejaculation, urinary incontinence and female sterility.
3. Semen Cuscutae：It is that the flat good medicine for mending kidney,liver,spleen, clinic are mainly used in lumbago due to the kidney deficiency, impotence and seminal emission, urine simply
Frequently, the kidney yin yang deficiency syndrome of the dark loose stool of uterus cold infertile, mesh.
4. the fruit of Chinese magnoliavine：Contain schizandrin (Schisandrin C23H3206) and vitamin C, resin, tannin and a small amount of
Carbohydrate.Have and astringe the lung to stop cough, nourish puckery essence, the effect of antidiarrheal hidroschesis.
5. spongilla：With tonifying the kidney and support yang, the effect of astringent sperm contracting urine.It is usually used in impotence, passes out semen, gonorrhoea is small under cold of insufficiency type band
Fecal incontinence, scrotum is wet to itch.
6. radix glycyrrhizae：For the root and rhizome of herbaceos perennial radix glycyrrhizae, property sweet taste, the thoughts of returning home, lung, spleen, stomach.Has tonifying spleen
QI invigorating, moisten the lung and relieve the cough, relieving spasm to stop pain, the work(for relaxing the property of medicine.
7. cynomorium songaricum：Can kidney tonifying, strengthening the essence, moisturize, impotence and seminal emission, soreness and weakness of waist and knees, dry constipation of intestines are cured mainly, to paralysing and improvement property
Function is weak to have certain effect.
8. Poria cocos：It is mild-natured, slightly sweet flavor, the people of all seminal emissions, no matter actual situation, all preferably eat, asthenic symptoms seminal emission, Poria cocos has the help heart
The work(of spleen, damp and hot seminal emission, Poria cocos have the effect of invigorating spleen to remove dampness.
9. prepared rhizome of rehmannia：It is sweet, slightly warm in nature, there is nourishing yin and supplementing blood, beneficial to spirit and marrow and other effects.Cure mainly the deficiency of liver-yin and kidney-yin, waist and knee acid
Soft, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, dizziness and tinnitus, poliosis etc.
Disease.
10. the bighead atractylodes rhizome：Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of, for spleen eating less, abdominal distention diarrhea, phlegm and retained fluid
Feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability.
11. matrimony vine：Nourishing the liver, nourshing kidney, moistening lung.
12. Semen Juglandis：Walnut is sweet, warm-natured；Enter kidney, lung channel；It can invigorate the kidney and stop nocturnal emission, warm lung Dingchuan, relax bowel；Cure mainly kidney
Void asthma is coughed, pain in the back flaccidity of lower limbs, impotence and seminal emission, frequent urination, urolithiasis, dry feces.
13. moutan bark：Heat enters ying blood, febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, falls and flutters
The pain of injury, carbuncle sore tumefacting virus.
14. Fructus Corni：Contain 16 kinds of amino acid in pulp, in addition, containing element necessary to a large amount of human bodies.In addition, contain
There are the compositions such as physiologically active stronger saponin raw sugar, polysaccharide, malic acid, tartaric acid, phenols, resin, tannin and vitamin A, C.
Its sour-puckery flavor, there is nourishing, stomach invigorating, diuresis, filling liver kidney, replenishing qi and blood and other effects.
15. black soya bean：Composition containing abundant protein, unrighted acid, phosphide, calcium, phosphorus, iron, potassium, sodium, carrotene,
Vitamin B1, vitamin B2, vitamin B12, nicotinic acid, folic acid, gossypose, stachyose, choline, daizeol, saponin(e etc..Kidney tonifying
It is beneficial cloudy, invigorating spleen to remove dampness, except thermal detoxification.
16. sea-tangle：Contain the mineral matter elements such as abundant iodine.Sea-tangle heat content is low, protein content is medium, mineral matter is rich
Richness, have reducing blood lipid, hypoglycemic, regulation is immune, anticoagulation, antitumor, lead discharging removing toxic substances and a variety of biological functions such as anti-oxidant.
17. tomato：Promote the production of body fluid to quench thirst, stomach strengthening and digestion promoting, clearing away heat and removing summer, the function such as kidney tonifying diuresis, can control consumption of body fluid caused by febrile disease it is thirsty,
The illness such as Sheng in poor appetite, hot summer weather.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (1)
1. a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription includes component A, B component, it is characterised in that the component A bag
Include the following raw material counted in parts by weight：
60~65 portions of saline cistanches
30~35 parts of barrenwort
25~28 portions of Semen Cuscutaes
18~23 portions of fruit ofs Chinese magnoliavine
15~20 parts of spongillas
13~16 portions of radix glycyrrhizaes
6~7 parts of annex solutions；
The preparation method of the annex solution comprises the following steps：
(1) in mass ratio 2~4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder
Broken mixture, it is placed in standing 3~6h at 35~40 DEG C；
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and carry out
Concentration, the 50~55% of extract volume is concentrated into, collects concentrate, sterilizing, produce annex solution；
The B component includes the following raw material counted in parts by weight：
50~55 parts of cynomorium songaricums
40~45 parts of Poria cocos
36~42 parts of prepared rhizomes of rehmannia
32~35 parts of bighead atractylodes rhizomes
22~26 parts of moutan barks
14~17 portions of Fructus Cornis
10~12 parts of supplement powder；
The preparation method of the supplement powder comprises the following steps：
A. in mass ratio 12:4~6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with
0.5mol/L sodium chloride solutions in mass ratio 1:4~6 are put into digester and carry out boiling, collect cooking mixture；
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected and decolourize
Liquid, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114515007A (en) * | 2022-03-02 | 2022-05-20 | 文成国 | Diet therapy formula for treating kidney-yin deficiency and kidney-yang deficiency |
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