CN107812067A - A kind of preparation method for relieving pain strong bone capsule - Google Patents
A kind of preparation method for relieving pain strong bone capsule Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 62
- 239000002775 capsule Substances 0.000 title claims abstract description 43
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 20
- 239000011248 coating agent Substances 0.000 claims abstract description 56
- 238000000576 coating method Methods 0.000 claims abstract description 56
- 239000000463 material Substances 0.000 claims abstract description 21
- 239000002245 particle Substances 0.000 claims abstract description 19
- 238000011049 filling Methods 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 70
- 239000000843 powder Substances 0.000 claims description 51
- 238000003756 stirring Methods 0.000 claims description 22
- 239000006071 cream Substances 0.000 claims description 20
- 235000013399 edible fruits Nutrition 0.000 claims description 18
- 238000000605 extraction Methods 0.000 claims description 18
- 239000007931 coated granule Substances 0.000 claims description 14
- 244000226566 Psoralea corylifolia Species 0.000 claims description 12
- 241000830535 Ligustrum lucidum Species 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 241001148782 Davallia Species 0.000 claims description 8
- 244000241872 Lycium chinense Species 0.000 claims description 8
- 235000015468 Lycium chinense Nutrition 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 206010053615 Thermal burn Diseases 0.000 claims description 8
- 235000018905 epimedium Nutrition 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 230000000202 analgesic effect Effects 0.000 claims description 7
- 238000000889 atomisation Methods 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 238000010348 incorporation Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 235000020985 whole grains Nutrition 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 239000004570 mortar (masonry) Substances 0.000 claims description 5
- 241001016310 Epimedium grandiflorum Species 0.000 claims description 4
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 230000004584 weight gain Effects 0.000 claims description 3
- 235000019786 weight gain Nutrition 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 238000002386 leaching Methods 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 16
- 238000000034 method Methods 0.000 abstract description 10
- 238000010521 absorption reaction Methods 0.000 abstract description 8
- 238000003860 storage Methods 0.000 abstract description 3
- 239000008199 coating composition Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 7
- 229940079593 drug Drugs 0.000 description 5
- 241000424773 Epimedium alpinum Species 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 3
- TZJALUIVHRYQQB-XFDQAQKOSA-N Icariin Natural products O(C)c1ccc(C2=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)c3c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)c(C/C=C(\C)/C)c3O2)cc1 TZJALUIVHRYQQB-XFDQAQKOSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 description 2
- TZJALUIVHRYQQB-UHFFFAOYSA-N icariine Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(C)O2)O)C(=O)C2=C(O)C=C(OC3C(C(O)C(O)C(CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-UHFFFAOYSA-N 0.000 description 2
- 241000241550 Cyathula Species 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention provides a kind of preparation method of Chinese medicinal capsule preparation, more particularly to a kind of preparation method for relieving pain strong bone capsule, the coating formula of liquid of the particle moisture absorption and the preparation method of coating solution are prevented by a kind of, i.e. to manufactured particle, the filling of capsule is carried out after being coated with the coating solution mixed to particle again, particle and manufactured goods after being coated with the coating solution, solve the problems, such as that the medicine is being prepared and the filling and moisture absorption in storage process after it has been manufactured well, this method can reduce the material loss in product preparation process, improve yield, ensure the steady quality of medicine before the deadline simultaneously.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicinal capsule preparation, more particularly to a kind of preparation side for relieving pain strong bone capsule
Method.
Background technology
Product involved by the technology of the present invention is Chinese patent drug, and the plurality of active ingredients in herbal mixture medicinal extract is in high temperature and length
Under the drying condition of time, content mostly has a declining tendency, and contains index in analgesic strong bone capsule involved in the present invention
Property composition icariin, with the rise of temperature and drying time, it is more obvious to decline degree.Original manufacturing condition is given birth to
The content of the product active ingredient icariin of production is relatively low, by reducing the drying temperature of medicinal material extract medicinal extract, when shortening dry
Between, so that its content adds 25% on the original basis, but the medicine of drying condition is improved in follow-up formulation process
In, there is the phenomenon of particle hygroscopicity enhancing, cause medicine easy moisture absorption in the pouring process of capsule, cause drug weight
Difference is difficult to be controlled, and the particle after the moisture absorption is bonded in capsule shells not easy-clear, influences production efficiency and the presentation quality of medicine.Its
Secondary, medicine can absorb the moisture in capsule shells in storage process, capsule shells dehydration is become fragile and be easily broken, therefore usually draw
Send out drug quality numerous and complain, final medicine particle bonding can also occur because absorbing moisture, cause moisture, disintegration time limited to exceed state
Control requirement of family's pharmacopeia to capsule, and the problems such as character does not meet the regulation of quality standard.Problem above both have impact on
Product quality and pharmaceutical effectiveness, while corporate image is also influenced whether, and loss economically can be brought to enterprise.It is therefore general
Protection against the tide is carried out using measures such as the relatively good packaging of the moisture resistance of costliness or additional aluminium foil moisture barrier bags, but therefore correspondingly increased
Production process and cost, extend the production cycle, reduce production efficiency.
The content of the invention
It is an object of the invention to provide a kind of modified preparation method for relieving pain strong bone capsule, to solve product quality raising
Afterwards, then former preparation method was used fully to solve medicine particle hygroscopicity problems, so as to cause filling of the medicine in capsule
The easy moisture absorption during dress, causes drug weight difference to be difficult to control, and the particle after the moisture absorption is bonded in capsule shells not easy-clear, shadow
Production efficiency and the presentation quality of medicine are rung, and in medicine in storage process, easily absorbs the moisture in capsule shells, makes capsule shells
Dehydration, which becomes fragile, to be easily broken, the defects of influenceing drug quality.
Technical scheme is as follows：
The analgesic strong bone capsule prescription of the present invention：
The psoralea corylifolia 583.5g barrenwort 583.5g fruit of Chinese wolfberry 417g fruit of glossy privet 417g rhizomes of davallia（Scald）333g rhizoma cibotii 333g
Radix cyathulae 333g
The preparation method of strong bone capsule is relieved pain, is comprised the following steps：
（1）The preparation of dried cream powder：Psoralea corylifolia, the fruit of glossy privet add 75% ethanol to soak 30 minutes, and refluxing extraction is secondary, add 10 for the first time
Times amount extraction 2.5 hours, second plus 8 times of amount extractions 2 hours, merge extract solution, reclaim ethanol and be concentrated into relative density and be
1.35~1.38 medicinal extract, temperature is 80 DEG C, standby；Take barrenwort, the fruit of Chinese wolfberry, the rhizome of davallia（Scald）, rhizoma cibotii and radix cyathulae and benefit
Bone fat, the dregs of a decoction of the fruit of glossy privet merge, and soak 30 minutes, and decoction is secondary, and for the first time plus 6 times of decoctings are boiled 2.0 hours, second
Add 4 times of decoctings to boil 1.5 hours, collecting decoction, be concentrated into the clear cream that relative density is 1.05~1.07, temperature is 80 DEG C, adds second
Alcohol makes alcohol content stir evenly, stand, take supernatant, reclaim ethanol and be concentrated into the leaching that relative density is 1.35~1.38 up to 70%
Cream, temperature is 80 DEG C, standby；Merge described two medicinal extract, under -0.07~-0.09MPa vacuum condition, 70~75 DEG C subtract
Press dry dry, be ground into fine powder, get dry extract powder；
（2）The preparation of mixed material：Take step（1）Described dried cream powder and starch, 108 revs/min of stirring slurry, granulating cutter are set
1008 revs/min, incorporation time 30 minutes, obtain mixed material；
（3）It is coated the preparation of powder：Take 3~8 parts of hydroxypropyl methylcellulose, 0.5~2.5 part of polyvinylpyrrolidone, polyethylene glycol
0.3~2.5 part and 0.5~2.5 part of ethyl cellulose, mix and produce coating powder；
（4）The preparation of coating solution：85~90% ethanol are added in mortar mixer, stirring, is slowly homogeneously added into step in advance（3）
Described coating powder, after continuously stirring 30~40 minutes, the coating solution that concentration is 20% is made；
（5）The preparation of coated granule：By step（2）Described mixed material is placed in spray-drying pelleting machine, is preheated 5 minutes
Afterwards, step is sprayed into（4）Described coating solution, flow are 65~75ml/min, spraying granulation, coating, set the main air duct temperature to be
80 DEG C, auxiliary wind duct temperature is 70 DEG C, during temperature of charge be 45~55 DEG C, primary atomization pressure 0.10~0.25MPa, it is secondary
0.35~0.50MPa of atomizing pressure, spray gun frequency are 45Hz, and drying time is 30~35 minutes, and gained mean particle size is
16 mesh, moisture are 3~5%, and coating powder dosage is the 2.0~2.5% of weight gain, produces coated granule；
（6）The preparation of capsule：Step（5）Coated granule, whole grain, sieving are filling, and capsule 1000 is made.
Wherein, step（3）In preferably 5 parts of hydroxypropyl methylcellulose, preferably 1.5 parts of polyvinylpyrrolidone, polyethylene glycol
It is preferred that 1.8 parts, preferably 1.8 parts of ethyl cellulose.
Step（5）In coating solution the preferred 70ml/min of penetrating flow；The preferred 0.20MPa of primary atomization pressure；It is secondary
The preferred 0.40MPa of atomizing pressure.
Wherein, step（4）The preparation of described coating solution can also be step（3）Described coating powder is dissolved in 85
In~90% ethanol, concentration is made and is 20% coating solution, then be ground through colloid mill, produce coating solution.
Beneficial effects of the present invention：
The invention provides the coated formula and method for preventing the particle moisture absorption, i.e., to manufactured particle, with the coating solution mixed
The filling of capsule is carried out after being coated to particle again, particle and manufactured goods after being coated with the coating solution are stable through product
Property experiment investigate 24 months and show, the moisture of product is reduced to 6% by original 12% after testing, and disintegration time limited was by original 1 hour
It is reduced to above 20 minutes or so, content averagely improves 25% on the original basis, solves product well using this method and exists
Moisture absorption problem in preparation process and after being made, this method can reduce the material loss in product preparation process, improve yield, and
Ensure the steady quality of product before the deadline.
Embodiment
Embodiment 1
Prescription：The psoralea corylifolia 583.5g barrenwort 583.5g fruit of Chinese wolfberry 417g fruit of glossy privet 417g rhizomes of davallia（Scald）333g rhizoma cibotii
333g radix cyathulaes 333g
The preparation method of strong bone capsule is relieved pain, is comprised the following steps：
（1）The preparation of dried cream powder：Psoralea corylifolia, the fruit of glossy privet add 75% ethanol to soak 30 minutes, and refluxing extraction is secondary, add 10 for the first time
Times amount extraction 2.5 hours, second plus 8 times of amount extractions 2 hours, merge extract solution, reclaim ethanol and be concentrated into relative density and be
The medicinal extract of 1.35~1.38 (80 DEG C), it is standby；Barrenwort, the fruit of Chinese wolfberry, the rhizome of davallia（Scald）, rhizoma cibotii and radix cyathulae and psoralea corylifolia, female
The dregs of a decoction of loyal son merge, and soak 30 minutes, and decoction is secondary, and for the first time plus 6 times of decoctings are boiled 2.0 hours, second plus 4 times of water
Decoct 1.5 hours, collecting decoction, be concentrated into the clear cream that relative density is 1.05~1.07 (80 DEG C), add ethanol to reach alcohol content
70%, stir evenly, stand, take supernatant, reclaim ethanol and be concentrated into the medicinal extract that relative density is 1.35~1.38 (80 DEG C), it is standby；
Merge above two medicinal extract, under -0.07~-0.09MPa vacuum conditions, 70~75 DEG C are dried under reduced pressure, and are ground into fine powder, get dry extract
Powder；
（2）The preparation of mixed material：Take above-mentioned dried cream powder and starch, 108.0 revs/min of stirring slurry is set, 1008 turns of granulating cutter/
Point, incorporation time 30 minutes, obtain mixed material；
（3）It is coated the preparation of powder：Take 3 parts of hydroxypropyl methylcellulose, 0.5 part of polyvinylpyrrolidone, 0.3 part of polyethylene glycol, second
0.5 part of base cellulose, mixes and produces coating powder；
（4）The preparation of coating solution：First 85~90% ethanol are added in mortar mixer, stirring, is slowly homogeneously added into above-mentioned bag in advance
Clothing powder, after continuously stirring 30~40 minutes, produce the coating solution that concentration is 20%；
（5）The preparation of coated granule：By step（2）The mixed material of gained is placed in spray-drying pelleting machine, is preheated 5 minutes
Afterwards, coating solution is sprayed into, flow 65ml/min, spraying granulation, coating, it is 80 DEG C to set main air duct temperature, and auxiliary wind duct temperature is 70
DEG C, during temperature of charge be 45~55 DEG C；Primary atomization pressure 0.10MPa, secondary-atomizing pressure 0.35MPa, spray gun frequency
For 45Hz, drying time is 30~35 minutes, and gained mean particle size is 16 mesh, and moisture is 3~5%；Coating powder dosage is
The 2.0~2.5% of grain weightening；
（6）The preparation of capsule：Made coated granule, whole grain, sieving are filling, and capsule 1000 is made.
Embodiment 2
The preparation method of strong bone capsule is relieved pain, is comprised the following steps：
（1）The preparation of dried cream powder：Psoralea corylifolia, the fruit of glossy privet add 75% ethanol to soak 30 minutes, and refluxing extraction is secondary, add 10 for the first time
Times amount extraction 2.5 hours, second plus 8 times of amount extractions 2 hours, merge extract solution, reclaim ethanol and be concentrated into relative density and be
The medicinal extract of 1.35~1.38 (80 DEG C), it is standby；Barrenwort, the fruit of Chinese wolfberry, the rhizome of davallia（Scald）, rhizoma cibotii and radix cyathulae and psoralea corylifolia, female
The dregs of a decoction of loyal son merge, and soak 30 minutes, and decoction is secondary, and for the first time plus 6 times of decoctings are boiled 2.0 hours, second plus 4 times of water
Decoct 1.5 hours, collecting decoction, be concentrated into the clear cream that relative density is 1.05~1.07 (80 DEG C), add ethanol to reach alcohol content
70%, stir evenly, stand, take supernatant, reclaim ethanol and be concentrated into the medicinal extract that relative density is 1.35~1.38 (80 DEG C), it is standby；
Merge above two medicinal extract, under -0.07~-0.09MPa vacuum conditions, 70~75 DEG C are dried under reduced pressure, and are ground into fine powder, get dry extract
Powder；
（2）The preparation of mixed material：Take above-mentioned dried cream powder and starch, 108.0 revs/min of stirring slurry is set, 1008 turns of granulating cutter/
Point, incorporation time 30 minutes, obtain mixed material；
（3）It is coated the preparation of powder：Take 8 parts of hydroxypropyl methylcellulose, 2.5 parts of polyvinylpyrrolidone, 2.5 parts of polyethylene glycol, second
2.5 parts of base cellulose, mixes and produces coating powder；
（4）The preparation of coating solution：First 85~90% ethanol are added in mortar mixer, stirring, is slowly homogeneously added into above-mentioned bag in advance
Clothing powder, after continuously stirring 30~40 minutes, produce the coating solution that concentration is 20%；
（5）The preparation of coated granule：By step（2）The mixed material of gained is placed in spray-drying pelleting machine, is preheated 5 minutes
Afterwards, coating solution is sprayed into, flow 75ml/min, spraying granulation, coating, it is 80 DEG C to set main air duct temperature, and auxiliary wind duct temperature is 70
DEG C, during temperature of charge be 45~55 DEG C；Primary atomization pressure 0.25MPa, secondary-atomizing pressure 0.50MPa, spray gun frequency
For 45Hz, drying time is 30~35 minutes, and gained mean particle size is 16 mesh, and moisture is 3~5%；Coating powder dosage is
The 2.0~2.5% of grain weightening；
（6）The preparation of capsule：Made coated granule, whole grain, sieving are filling, and capsule 1000 is made.
Embodiment 3
The preparation method of strong bone capsule is relieved pain, is comprised the following steps：
（1）The preparation of dried cream powder：Psoralea corylifolia, the fruit of glossy privet add 75% ethanol to soak 30 minutes, and refluxing extraction is secondary, add 10 for the first time
Times amount extraction 2.5 hours, second plus 8 times of amount extractions 2 hours, merge extract solution, reclaim ethanol and be concentrated into relative density and be
The medicinal extract of 1.35~1.38 (80 DEG C), it is standby；Barrenwort, the fruit of Chinese wolfberry, the rhizome of davallia（Scald）, rhizoma cibotii and radix cyathulae and psoralea corylifolia, female
The dregs of a decoction of loyal son merge, and soak 30 minutes, and decoction is secondary, and for the first time plus 6 times of decoctings are boiled 2.0 hours, second plus 4 times of water
Decoct 1.5 hours, collecting decoction, be concentrated into the clear cream that relative density is 1.05~1.07 (80 DEG C), add ethanol to reach alcohol content
70%, stir evenly, stand, take supernatant, reclaim ethanol and be concentrated into the medicinal extract that relative density is 1.35~1.38 (80 DEG C), it is standby；
Merge above two medicinal extract, under -0.07~-0.09MPa vacuum conditions, 70~75 DEG C are dried under reduced pressure, and are ground into fine powder, get dry extract
Powder；
（2）The preparation of mixed material：Take above-mentioned dried cream powder and starch, 108.0 revs/min of stirring slurry is set, 1008 turns of granulating cutter/
Point, incorporation time 30 minutes, obtain mixed material；
（3）It is coated the preparation of powder：Take 5 parts of hydroxypropyl methylcellulose, 1.5 parts of polyvinylpyrrolidone, 1.8 parts of polyethylene glycol, second
1.8 parts of base cellulose, mixes and produces coating powder；
（4）The preparation of coating solution：First 85~90% ethanol are added in mortar mixer, stirring, is slowly homogeneously added into above-mentioned bag in advance
Clothing powder, after continuously stirring 30~40 minutes, produce the coating solution that concentration is 20%；
（5）The preparation of coated granule：By step（2）The mixed material of gained is placed in spray-drying pelleting machine, is preheated 5 minutes
Afterwards, coating solution is sprayed into, flow 70ml/min, spraying granulation, coating, it is 80 DEG C to set main air duct temperature, and auxiliary wind duct temperature is 70
DEG C, during temperature of charge be 45~55 DEG C；Primary atomization pressure 0.20MPa, secondary-atomizing pressure 0.40MPa, spray gun frequency
For 45Hz, drying time is 30~35 minutes, and gained mean particle size is 16 mesh, and moisture is 3~5%；Coating powder dosage is
The 2.0~2.5% of grain weightening；
（6）The preparation of capsule：Made coated granule, whole grain, sieving are filling, and capsule 1000 is made.
Embodiment 4
The preparation method of strong bone capsule is relieved pain, is comprised the following steps：
（1）The preparation of dried cream powder：Psoralea corylifolia, the fruit of glossy privet add 75% ethanol to soak 30 minutes, and refluxing extraction is secondary, add 10 for the first time
Times amount extraction 2.5 hours, second plus 8 times of amount extractions 2 hours, merge extract solution, reclaim ethanol and be concentrated into relative density and be
The medicinal extract of 1.35~1.38 (80 DEG C), it is standby；Barrenwort, the fruit of Chinese wolfberry, the rhizome of davallia（Scald）, rhizoma cibotii and radix cyathulae and psoralea corylifolia, female
The dregs of a decoction of loyal son merge, and soak 30 minutes, and decoction is secondary, and for the first time plus 6 times of decoctings are boiled 2.0 hours, second plus 4 times of water
Decoct 1.5 hours, collecting decoction, be concentrated into the clear cream that relative density is 1.05~1.07 (80 DEG C), add ethanol to reach alcohol content
70%, stir evenly, stand, take supernatant, reclaim ethanol and be concentrated into the medicinal extract that relative density is 1.35~1.38 (80 DEG C), it is standby；
Merge above two medicinal extract, under -0.07~-0.09MPa vacuum conditions, 70~75 DEG C are dried under reduced pressure, and are ground into fine powder, get dry extract
Powder；
（2）The preparation of mixed material：Take above-mentioned dried cream powder and starch, 108.0 revs/min of stirring slurry is set, 1008 turns of granulating cutter/
Point, incorporation time 30 minutes, obtain mixed material；
（3）It is coated the preparation of powder：Take 6 parts of hydroxypropyl methylcellulose, 1.5 parts of polyvinylpyrrolidone, 2 parts of polyethylene glycol, ethyl
2 parts of cellulose, mixes and produces coating powder；
（4）The preparation of coating solution：By step（3）Described coating powder is dissolved in 85~90% ethanol, and concentration, which is made, is
20% coating solution, then be ground through colloid mill, produce coating solution.
（5）The preparation of coated granule：By step（2）The mixed material of gained is placed in spray-drying pelleting machine, preheats 5 points
Zhong Hou, coating solution is sprayed into, flow 70ml/min, spraying granulation, coating, it is 80 DEG C to set main air duct temperature, and auxiliary wind duct temperature is
70 DEG C, during temperature of charge be 45~55 DEG C；Primary atomization pressure 0.22MPa, secondary-atomizing pressure 0.38MPa, spray gun frequency
Rate is 45Hz, and drying time is 30~35 minutes, and gained mean particle size is 16 mesh, and moisture is 3~5%；Coating powder dosage is
The 2.0~2.5% of weight gain；
（6）The preparation of capsule：Made coated granule, whole grain, sieving are filling, and capsule 1000 is made.
Claims (6)
1. a kind of preparation method for relieving pain strong bone capsule, it is characterised in that comprise the following steps：
（1）The preparation of dried cream powder：Psoralea corylifolia, the fruit of glossy privet add 75% ethanol to soak 30 minutes, and refluxing extraction is secondary, add 10 for the first time
Times amount extraction 2.5 hours, second plus 8 times of amount extractions 2 hours, merge extract solution, reclaim ethanol and be concentrated into relative density and be
1.35~1.38 medicinal extract, temperature is 80 DEG C, standby；Take barrenwort, the fruit of Chinese wolfberry, the rhizome of davallia（Scald）, rhizoma cibotii and radix cyathulae and benefit
Bone fat, the dregs of a decoction of the fruit of glossy privet merge, and soak 30 minutes, and decoction is secondary, and for the first time plus 6 times of decoctings are boiled 2.0 hours, second
Add 4 times of decoctings to boil 1.5 hours, collecting decoction, be concentrated into the clear cream that relative density is 1.05~1.07, temperature is 80 DEG C, adds second
Alcohol makes alcohol content stir evenly, stand, take supernatant, reclaim ethanol and be concentrated into the leaching that relative density is 1.35~1.38 up to 70%
Cream, temperature is 80 DEG C, standby；Merge described two medicinal extract, under -0.07~-0.09MPa vacuum condition, 70~75 DEG C subtract
Press dry dry, be ground into fine powder, get dry extract powder；
（2）The preparation of mixed material：Take step（1）Described dried cream powder and starch, 108 revs/min of stirring slurry, granulating cutter are set
1008 revs/min, incorporation time 30 minutes, obtain mixed material；
（3）It is coated the preparation of powder：Take 3~8 parts of hydroxypropyl methylcellulose, 0.5~2.5 part of polyvinylpyrrolidone, polyethylene glycol
0.3~2.5 part and 0.5~2.5 part of ethyl cellulose, mix and produce coating powder；
（4）The preparation of coating solution：By 85~90% ethanol and step（3）Described coating powder is mixed and made into the bag that concentration is 20%
Clothing liquid；
（5）The preparation of coated granule：By step（2）Described mixed material is placed in spray-drying pelleting machine, is preheated 5 minutes
Afterwards, step is sprayed into（4）Described coating solution, flow are 65~75ml/min, spraying granulation, coating, set the main air duct temperature to be
80 DEG C, auxiliary wind duct temperature is 70 DEG C, during temperature of charge be 45~55 DEG C, primary atomization pressure 0.10~0.25MPa, it is secondary
0.35~0.50MPa of atomizing pressure, spray gun frequency are 45Hz, and drying time is 30~35 minutes, and gained mean particle size is
16 mesh, moisture are 3~5%, and coating powder dosage is the 2.0~2.5% of weight gain, produces coated granule；
（6）The preparation of capsule：Step（5）Described coated granule, whole grain, sieving are filling, and capsule 1000 is made.
2. the preparation method of analgesic strong bone capsule according to claim 1, it is characterised in that：Step（3）Described hydroxypropyl
Methylcellulose is 5 parts, and described polyvinylpyrrolidone is 1.5 parts, and described polyethylene glycol is 1.8 parts, and described ethyl is fine
Dimension element is 1.8 parts.
3. the preparation method of analgesic strong bone capsule according to claim 1, it is characterised in that：Step（4）Described coating
Liquid is prepared as adding 85~90% ethanol in mortar mixer, and stirring, is slowly homogeneously added into step in advance（3）Described coating
Powder, after continuously stirring 30~40 minutes, the coating solution that concentration is 20% is made；Or by step（3）Described coating powder dissolving
In 85~90% ethanol, concentration is made and is 20% coating solution, then be ground through colloid mill, produce coating solution.
4. the preparation method of analgesic strong bone capsule according to claim 1, it is characterised in that：Step（5）Described coating
The penetrating flow of liquid is 70ml/min.
5. the preparation method of analgesic strong bone capsule according to claim 1, it is characterised in that：Step（5）It is described once
Atomizing pressure is 0.20MPa.
6. the preparation method of analgesic strong bone capsule according to claim 1, it is characterised in that：Step（5）Described is secondary
Atomizing pressure is 0.40MPa.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931280A (en) * | 2006-09-24 | 2007-03-21 | 四川美大康药业股份有限公司 | Medicine for treating osteoporosis and its prepn process |
| CN103040952A (en) * | 2012-12-14 | 2013-04-17 | 四川美大康药业股份有限公司 | Moistureproof coating method of dangfei liganning capsule |
| CN103239590A (en) * | 2013-04-23 | 2013-08-14 | 江苏济川制药有限公司 | Traditional Chinese medicine composition as well as preparation and application thereof |
-
2017
- 2017-12-18 CN CN201711367544.1A patent/CN107812067A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931280A (en) * | 2006-09-24 | 2007-03-21 | 四川美大康药业股份有限公司 | Medicine for treating osteoporosis and its prepn process |
| CN103040952A (en) * | 2012-12-14 | 2013-04-17 | 四川美大康药业股份有限公司 | Moistureproof coating method of dangfei liganning capsule |
| CN103239590A (en) * | 2013-04-23 | 2013-08-14 | 江苏济川制药有限公司 | Traditional Chinese medicine composition as well as preparation and application thereof |
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Application publication date: 20180320 |