CN107802955B - Steep pulse electric field tumor treatment electrode - Google Patents
Steep pulse electric field tumor treatment electrode Download PDFInfo
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- CN107802955B CN107802955B CN201711137761.1A CN201711137761A CN107802955B CN 107802955 B CN107802955 B CN 107802955B CN 201711137761 A CN201711137761 A CN 201711137761A CN 107802955 B CN107802955 B CN 107802955B
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- puncture needle
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- puncture
- electric field
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/06—Electrodes for high-frequency therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
本发明涉及一种陡脉冲电场肿瘤治疗电极，陡脉冲电场肿瘤治疗电极包括固定盘、转向盘、至少三根金属穿刺针，每根金属穿刺针的后端套设具有把持件，空腔内设置有注药嘴以及与金属穿刺针连接的金属连接件，每根金属穿刺针的外周面包裹有绝缘保护层，且使金属穿刺针的前端形成裸露部，裸露部设置有多个与过水通道连通的注药孔，其中一根金属穿刺针作为中心固定穿刺针，中心固定穿刺针依次贯穿固定盘与转向盘，剩余金属穿刺针则作为活动穿刺针，活动穿刺针分别从转向盘上的穿刺针活动孔穿过，活动穿刺针的把持件分别可活动地卡设于固定盘上的把持件活动孔中。本发明的陡脉冲电场肿瘤治疗电极具有结构简单、治疗效果好、使用成本低和手术时间短的优点。
The invention relates to a steep pulse electric field tumor treatment electrode. The steep pulse electric field tumor treatment electrode includes a fixed disk, a steering wheel, and at least three metal puncture needles. The rear end of each metal puncture needle is equipped with a holding member, and a holding member is provided in the cavity. The injection nozzle and the metal connector connected to the metal puncture needle. The outer peripheral surface of each metal puncture needle is wrapped with an insulating protective layer, and the front end of the metal puncture needle forms an exposed part. The exposed part is provided with multiple water passages connected to it. injection hole, one of the metal puncture needles is used as a central fixed puncture needle, and the central fixed puncture needle penetrates the fixed plate and the steering wheel in sequence, and the remaining metal puncture needles are used as movable puncture needles, and the movable puncture needles are separated from the puncture needles on the steering wheel. The movable hole passes through, and the holding parts of the movable puncture needle are respectively movably clamped in the movable holes of the holding part on the fixed plate. The steep pulse electric field tumor treatment electrode of the present invention has the advantages of simple structure, good treatment effect, low use cost and short operation time.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a steep pulse electric field tumor treatment electrode.
Background
Cancer is one of the major diseases threatening human health and life, and is indicated according to one item of data published by the universal anticancer alliance (UICC): in 2008, cancer patients worldwide were 1270 ten thousand, with deaths reaching 760 ten thousand. The statistics report of the Chinese Ministry of health also shows that: cancer mortality has increased by more than eight years over the past 30 years, and cancer has become the leading disease and health killer of importance leading to death of urban and rural residents. Reports of the World Health Organization (WHO) also indicate: the mortality rate of newly increased cancer cases and cancer patients will also increase at 1% per year worldwide, whereas in developing countries such as china, russia, india etc. the rate of increase will be faster, and it is expected that 2700 thousands of cancer cases will increase worldwide and 1700 thousands of people die from cancer by 2030.
At present, the treatment methods of cancers mainly comprise operation treatment, radiation treatment, chemotherapy and the like, but the traditional treatment methods are limited by factors such as indication, contraindications, side effects and the like, so the treatment effect is still not ideal, and therefore, the search for new treatment methods of cancers is always an important subject in the medical field and the biomedical engineering field.
Recent studies have found that after electroporation, the cell will undergo irreversible electrical breakdown of the cell membrane with increasing pulse intensity and increasing pulse duration, causing cell membrane rupture until cell death. By utilizing the characteristic, researchers propose irreversible electroporation therapy, which is a novel non-thermal tumor ablation means, wherein electric pulses are applied to cancer tissues to cause irreversible electric breakdown of cancer cells, so that the survival condition of the cancer cells is destroyed, and the purpose of killing the cancer cells is achieved. However, the existing puncture needles penetrate through a plurality of puncture needles in the same sleeve, and because the puncture needles are limited by the inner diameter of the sleeve, the puncture needles are small in diameter and easy to damage, and the puncture needles are poor in depth accuracy of inserting into pathological tissues, so that the treatment effect is greatly reduced.
Disclosure of Invention
The invention aims to provide a steep pulse electric field tumor treatment electrode which is used for solving the problems that an existing puncture needle is easy to damage and the depth accuracy of the puncture needle inserted into pathological tissues is poor.
In order to achieve the above object, the present invention provides a steep pulse electric field tumor treatment electrode, the steep pulse electric field tumor treatment electrode includes a fixed disk, a steering disk, at least three metal puncture needles with front ends in a pointed cone shape, a water passing channel is provided in each metal puncture needle, a holding member with a cavity is sleeved at the rear end of each metal puncture needle, a medicine injection nozzle communicated with the water passing channel and a metal connecting member connected with the metal puncture needles are provided in the cavity, an insulating protection layer is wrapped on the outer circumferential surface of each metal puncture needle, and the front ends of the metal puncture needles form exposed parts, the exposed parts are provided with a plurality of medicine injection holes communicated with the water passing channel, the fixed disk and the steering disk are arranged in parallel, one metal puncture needle is used as a central fixed puncture needle, the central fixed puncture needles sequentially penetrate through the fixed disk and the steering disk, the remaining metal puncture needles are used as movable puncture needles, and the movable puncture needles respectively penetrate through the movable puncture needles on the movable holding member of the steering disk, and the movable puncture needles can be respectively arranged in the movable holding member.
Preferably, at least one metal puncture needle of the remaining metal puncture needles is used as a peripheral fixed puncture needle, the peripheral fixed puncture needle penetrates through the steering wheel, and a holding piece at the rear end of the peripheral fixed puncture needle is connected with the fixed disk.
Preferably, a connecting piece is arranged in the middle of each movable puncture needle and the middle of each peripheral fixed puncture needle, one end of the connecting piece is connected with the central fixed puncture needle, and the other end of the connecting piece is connected with the movable puncture needles or the peripheral fixed puncture needles.
Preferably, a positioning piece is arranged on the holding piece of each movable puncture needle, a plurality of tooth grooves are formed in the edges of the fixed disc and the steering wheel, and the positioning pieces are clamped in the tooth grooves.
Preferably, the metal puncture needle is provided with a scale.
Preferably, the length of the exposed part at the front end of the metal puncture needle is more than 2cm.
Preferably, the drug injection holes are equidistantly arranged at the exposed part of the front end of the metal puncture needle.
Preferably, the cross section of the metal puncture needle is circular.
Preferably, the outer diameter of the metal puncture needle is 0.15-1.5mm.
The invention has the following advantages: the steep pulse electric field tumor treatment electrode of the invention leads current into the lesion part of a patient through the metal puncture needle, leads liquid medicine into the lesion through the water channel inside the metal puncture needle, and kills tumor cells through combining electric shock treatment and drug treatment, thereby achieving the purpose of curing tumors. The steep pulse electric field tumor treatment electrode has the advantages of simple structure, good treatment effect, low use cost and short operation time.
Drawings
Fig. 1 is a schematic side view of a steep pulse electric field tumor treating electrode according to embodiment 1 of the invention.
Fig. 2 is a schematic diagram showing the bottom view structure of a steep pulse electric field tumor treating electrode according to embodiment 1 of the invention.
Fig. 3 is a schematic top view of a steep pulse electric field tumor treating electrode according to embodiment 1 of the invention.
Description of the embodiments
The following examples are illustrative of the invention and are not intended to limit the scope of the invention.
Examples
As shown in fig. 1, 2 and 3, the steep pulse electric field tumor treatment electrode comprises a fixed disk 7, a steering wheel 8 and four metal puncture needles, and the steep pulse electric field tumor treatment electrode of the invention leads current into a lesion part of a patient through the metal puncture needles, leads liquid medicine into the lesion through a water channel in the metal puncture needles, and kills tumor cells through combining electric shock treatment and drug treatment, thereby achieving the purpose of curing tumors. The steep pulse electric field tumor treatment electrode has the advantages of simple structure, good treatment effect, low use cost and short operation time.
The front end of the metal puncture needle is in a pointed cone shape so that the metal puncture needle can be easily inserted into a lesion part of a patient, a water passing channel is arranged in the metal puncture needle along the length direction of the metal puncture needle, the cross section of the metal puncture needle is in a circular shape, the outer diameter of the metal puncture needle is 0.15-1.5mm, and the specific value of the outer diameter of the metal puncture needle obtains an optimal value according to experimental results. The steep pulse electric field tumor treating electrode in the embodiment is not limited by the external sleeve, and the diameter of the steep pulse electric field tumor treating electrode can be properly increased, so that the metal puncture needle in the embodiment has higher structural strength and is not easy to damage. The outside parcel one deck of metal pjncture needle makes the metal pjncture needle front end keep naked insulating protection layer 5, and insulating protection layer 5 is made for plastics, medical macromolecular material, rubber or other materials, and in this embodiment, the length of the naked portion of metal pjncture needle front end is 4cm, and the naked portion of metal pjncture needle front end is provided with a plurality of injection holes 12 that communicate with water channel, in order to make the tissue of the different degree of depth of liquid medicine infiltration patient lesion site, the equidistant interval arrangement of injection hole 12 in this embodiment is in the naked portion of metal pjncture needle front end. The front end of the holding piece 2 is fixedly sleeved at the rear end of the metal puncture needle, the rear end of the holding piece 2 is provided with a cavity, a medicine injection nozzle and a metal connecting piece 23 are arranged in the cavity, the side wall of the holding piece 2 is provided with a medicine injection port 17 communicated with the medicine injection nozzle, the medicine injection nozzle is communicated with a water passage, when the medicine injection nozzle is used, the medicine injection port 17 is connected with a medicine liquid injector through a pipeline, and medicine liquid injected by the medicine liquid injector flows out from each medicine injection hole 12 through the water passage and permeates into tissues with different depths of lesion parts of a patient. The metal connecting piece 23 is connected with the metal puncture needle, and the metal connecting piece 23 is connected with a high-voltage pulse power supply through a wire. One metal puncture needle is used as a central fixed puncture needle 1, one metal puncture needle is used as a peripheral fixed puncture needle 3, and the remaining two metal puncture needles are used as movable puncture needles 4.
The fixed disk 7 and the steering wheel 8 are arranged in parallel, the fixed disk 7 and the steering wheel 8 are of circular plate-shaped structures, two arc-shaped holding piece movable holes are symmetrically formed in the fixed disk 7, the width of each holding piece movable hole is matched with the outer diameter of the holding piece 2 at the rear end of the movable puncture needle 4, and likewise, two arc-shaped puncture needle movable holes 6 are formed in the steering wheel 8 and correspond to the positions of the puncture needle movable holes 6 one by one. The center fixed puncture needle 1 sequentially penetrates through the centers of the fixed disc 7 and the steering disc 8, the two movable puncture needles 4 respectively penetrate through puncture needle movable holes 6 on the steering disc 8, the holding pieces 2 of the movable puncture needles 4 are respectively movably clamped in the movable holes of the holding pieces 2 on the fixed disc 7, the periphery fixed puncture needles 3 penetrate through the steering disc 8, and the holding pieces 2 at the rear ends of the periphery fixed puncture needles 3 are connected with the fixed disc 7.
Further, in order to strengthen the structural strength of the metal puncture needles, a connecting piece 9 is arranged in the middle of each movable puncture needle 4 and the peripheral fixed puncture needle 3, one end of the connecting piece 9 is movably sleeved in the middle of the central fixed puncture needle 1, the other end of the connecting piece 9 is provided with a clamping groove 10 with a C-shaped cross section, and the other end of the connecting piece 9 is movably clamped on the outer peripheral surface of the movable puncture needle 4 or the peripheral fixed puncture needle 3 through the clamping groove 10, so that the connection between the movable puncture needle 4 and the peripheral fixed puncture needle 3 and the central fixed puncture needle 1 is realized through the connecting piece 9.
Further, the holding member 2 of each movable puncture needle 4 is provided with a positioning member 16, the positioning member 16 comprises an elastic portion 15 and two flying wing portions 14 respectively connected to two ends of the elastic portion 15, the elastic portion 15 has a certain radian, so that the elastic portion 15 has elasticity which is certain to restore to an original shape after deformation, the connection position of the elastic portion 15 and the two flying wing portions 14 is respectively provided with a protruding edge, the edges of the fixed disc 7 and the steering wheel 8 are provided with a plurality of tooth grooves 11, the protruding edges are clamped in the tooth grooves 11, so that the movable puncture needles 4 are kept fixed and cannot move, when the position of the movable puncture needles 4 need to be adjusted, the two flying wing portions 14 are pressed by hands, the elastic portion 15 is deformed, the protruding edges are separated from the tooth grooves 11, when the position of the movable puncture needles 4 is adjusted to a preset position, the two flying wing portions 14 are released again, the elastic portion 15 restores to the original shape, and the protruding edges are clamped in the tooth grooves 11.
Examples
The embodiment is based on embodiment 1, and the difference between the embodiment and embodiment 1 is that the metal puncture needle in the embodiment is provided with the scale 13, and medical staff can intuitively observe the depth of the metal puncture needle inserted into the lesion part of a patient according to the scale 13 to treat tissues with different depths of the lesion part.
Working principle: the position of the two movable puncture needles 4 is firstly adjusted, the central fixed puncture needle 1, the peripheral fixed puncture needle 3 and the movable puncture needles 4 are inserted into the lesion part of a patient, the central fixed puncture needle 1 is connected with the output end of the high-voltage pulse power supply through a wire, the peripheral fixed puncture needle 3 or the movable puncture needles 4 are connected with the input end of the high-voltage pulse power supply through a wire, the high-frequency high-voltage pulse current output by the high-voltage pulse power supply is led into the lesion part of the patient through the central fixed puncture needle 1, the peripheral fixed puncture needle 3 or the movable puncture needles 4 serve as a loop electrode to lead the high-frequency high-voltage pulse current into the input end of the high-voltage pulse power supply, when the high-frequency high-voltage pulse current passes through the lesion cells of the patient, the high-frequency high-voltage pulse current can damage the cell membranes of the lesion cells, and thus the lesion cells are killed, and as the peripheral fixed puncture needles 3 or the movable puncture needles 4 serve as loop electrodes, the high-frequency high-voltage pulse current only passes through the lesion part, and can not damage healthy cells outside the lesion tissues. Meanwhile, the liquid medicine can be injected into the medicine injection openings 17 of the central fixed puncture needle 1, the peripheral fixed puncture needle 3 and the movable puncture needle 4 through the liquid medicine injector, so that the liquid medicine flows out from each medicine injection opening and permeates into tissues with different depths of lesion parts of a patient, and tumor cells can be killed more rapidly through combination of electric shock treatment and medicine treatment, and the treatment effect is improved.
While the invention has been described in detail in the foregoing general description and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.
Claims (9)
1. The steep pulse electric field tumor treatment electrode comprises a fixed disk, a steering disk and at least three metal puncture needles with front ends in a sharp cone shape, and is characterized in that a water passing channel is arranged in each metal puncture needle, a holding piece with a cavity is sleeved at the rear end of each metal puncture needle, a medicine injection nozzle communicated with the water passing channel and a metal connecting piece connected with the metal puncture needles are arranged in the cavity, the outer peripheral surface of each metal puncture needle is wrapped with an insulating protection layer, the front ends of the metal puncture needles form exposed parts, the exposed parts are provided with a plurality of medicine injection holes communicated with the water passing channel, the fixed disk and the steering disk are arranged in parallel, one metal puncture needle is used as a central fixed puncture needle, the central fixed puncture needle sequentially penetrates through the fixed disk and the steering disk, the remaining metal puncture needles are used as movable puncture needles, at least one metal puncture needle in the remaining metal puncture needles is used as periphery fixed puncture needles, the movable puncture needles can respectively penetrate through the movable puncture needles on the movable puncture disks from the movable puncture discs, and the movable puncture needles can be respectively held by the movable puncture needles on the movable puncture discs;
the metal connecting piece is connected with the high-voltage pulse power supply through a wire;
the central fixed puncture needle is connected with the output end of the high-voltage pulse power supply through a lead, and is used for guiding the high-frequency high-voltage pulse current output by the high-voltage pulse power supply into the lesion part of the patient; the peripheral fixed puncture needle or the movable puncture needle is connected with the input end of the high-voltage pulse power supply through a lead, and is used as a loop electrode for guiding high-frequency high-voltage pulse current into the input end of the high-voltage pulse power supply, so that the high-frequency high-voltage pulse current only passes through a lesion part and does not damage healthy cells outside the lesion tissue; when the high-frequency high-voltage pulse current passes through the diseased cells of the patient, the high-frequency high-voltage pulse current can damage the cell membranes of the diseased cells, so that the diseased cells are killed.
2. The steep pulse electric field tumor treating electrode according to claim 1, wherein the peripherally fixed puncture needle penetrates the steering wheel, and a grip at the rear end of the peripherally fixed puncture needle is connected with the fixed disk.
3. The steep pulse electric field tumor treating electrode according to claim 2, wherein a connecting piece is provided in the middle of each of the movable puncture needle and the peripheral fixed puncture needle, one end of the connecting piece is connected with the central fixed puncture needle, and the other end is connected with the movable puncture needle or the peripheral fixed puncture needle.
4. The steep pulse electric field tumor treating electrode according to claim 3, wherein a positioning member is provided on each of the holding members of the movable puncture needles, a plurality of tooth grooves are provided on the edges of the fixed disk and the steering disk, and the positioning members are caught in the tooth grooves.
5. The steep pulse electric field tumor treating electrode according to claim 1, wherein the metal puncture needle is provided with graduations.
6. The steep pulse electric field tumor treating electrode according to claim 2, wherein the length of the exposed portion of the metallic needle tip is greater than 2cm.
7. The steep pulse electric field tumor treating electrode according to claim 1, wherein the drug injection holes are equally spaced apart at the exposed portion of the front end of the metal puncture needle.
8. The steep pulse electric field tumor treating electrode according to claim 1, wherein the metal puncture needle has a circular cross section.
9. The steep pulse electric field tumor treating electrode according to claim 1, wherein the outer diameter of the metal piercing needle is 0.15-1.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711137761.1A CN107802955B (en) | 2017-11-16 | 2017-11-16 | Steep pulse electric field tumor treatment electrode |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711137761.1A CN107802955B (en) | 2017-11-16 | 2017-11-16 | Steep pulse electric field tumor treatment electrode |
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| Publication Number | Publication Date |
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| CN107802955A CN107802955A (en) | 2018-03-16 |
| CN107802955B true CN107802955B (en) | 2024-03-22 |
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| CN201711137761.1A Expired - Fee Related CN107802955B (en) | 2017-11-16 | 2017-11-16 | Steep pulse electric field tumor treatment electrode |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113413172B (en) * | 2021-05-11 | 2023-09-29 | 重庆西山科技股份有限公司 | Electrosurgery Biopsy Needles, Electrosurgery Biopsy Needle Kits and Vacuum-Assisted Breast Biopsy Systems |
| CN116439821B (en) * | 2023-06-14 | 2023-10-17 | 浙江伽奈维医疗科技有限公司 | Multi-needle steep pulse ablation electrode device, radio frequency ablation device, method and system |
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| CN107802955A (en) | 2018-03-16 |
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