CN107801997A - A kind of aloe capsule with function of relaxing bowel and preparation method thereof - Google Patents
A kind of aloe capsule with function of relaxing bowel and preparation method thereof Download PDFInfo
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- CN107801997A CN107801997A CN201711242564.6A CN201711242564A CN107801997A CN 107801997 A CN107801997 A CN 107801997A CN 201711242564 A CN201711242564 A CN 201711242564A CN 107801997 A CN107801997 A CN 107801997A
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- aloe
- capsule
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- dry powder
- barbadensis miller
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The present invention relates to technical field of health care food, and in particular to a kind of aloe capsule with function of relaxing bowel and preparation method thereof.The active component of the aloe capsule is aloe dry powder.Preferably, the aloe dry powder is aloe barbadensis Miller full leaf dried powder.The active component content of aloe capsule provided by the invention is high, and no auxiliary material addition, simple production process, product is convenient for carrying, in good taste, has the effect of relaxing bowel, losing weight.
Description
Technical field
The present invention relates to technical field of health care food, and in particular to a kind of aloe capsule with function of relaxing bowel and its
Preparation method.
Background technology
Aloe is a kind of perennial Liliaceae succulent, is a kind of ancient traditional Chinese medicine, property bitter cold, enter the heart, liver,
Stomach, large intestine, there is the compound action of mystery, there is repair cell, anti-inflammatory, antibacterial.Domestic and international biological expert is through scientific research
Analytical proof, more than the 20 kinds of organic active ingredients such as Barbaloin, aloe-emodin are contained in aloe.Medical research is demonstrate,proved
It is bright：Aloe with treat constipation, the disease such as hypertension, gastritis is with auxiliary therapeutic action.
The content of the invention
First purpose of the present invention is to provide a kind of aloe capsule with function of relaxing bowel.
A kind of aloe capsule with function of relaxing bowel, its active component include aloe dry powder.
Preferably, the aloe dry powder is aloe barbadensis Miller full leaf dried powder.Aloe barbadensis Miller full leaf dried powder is Curacao reed
Obtained powder is crushed after luxuriant growth full leaf is lyophilized.With under rushing down, clear liver the effect of, be generally used for ease constipation, let out the effect of irascibility.
The active component content of aloe capsule provided by the invention is high, no auxiliary material addition, simple production process, and product is convenient
Carry, it is in good taste, there is the effect of relaxing bowel, losing weight.
Second object of the present invention is to provide a kind of preparation method for preparing above-mentioned aloe capsule：
Take the aloe dry powder to cross 60-150 mesh sieves, filling No. 1-No. 00 capsule, produce.
Wherein, the method for preparing aloe dry powder is：
1) by after the cleaned sterilization of Aloe Barbadensis Miller fresh leaf, peeling, aloe gel is obtained；
2) pectase is added to the aloe gel, the dosage of pectase is 60-80ppm, obtains zymolyte；
It is preferred that the dosage of pectase is 60ppm；
3) decolourized to zymolyte obtained by step 2), filter and remove residue, obtain aloe gel juice；
Preferably, the decolouring, which refers to diatomite combine using activated carbon, is decolourized, and dosage is 1.3g ± 0.5/L
(activated carbon)+1.6g ± 0.5/L (diatomite), under the conditions of 55 DEG C, decolouring 40min.
4) aloe gel juice is concentrated more than 5 times；Concentration condition is 20-25 DEG C of vacuum concentration；
5) it is aloe gel inspissated juice obtained by step 4) is freeze-dried, produce aloe barbadensis Miller full leaf dried powder.
Preferably, step 5) is：It will be frozen at temperature of the aloe gel inspissated juice obtained by step 4) below -30 DEG C
Dry, control water content is less than 6.0%, produces aloe barbadensis Miller full leaf dried powder.
The above method can preserve the nutritional ingredient of aloe to greatest extent so that aloe capsule tool provided by the present invention
There is more prominent effect.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
A kind of aloe barbadensis Miller full leaf dried powder is present embodiments provided, is prepared as follows：
1) by after the cleaned sterilization of Aloe Barbadensis Miller fresh leaf, peeling, aloe gel is obtained；
2) pectase is added into the aloe gel, obtains zymolyte；
The dosage of the pectase is 60ppm；
3) zymolyte obtained by step 2) is combined with activated carbon with diatomite and decolourized, activated carbon dosage 1.3g/L
(activated carbon)+1.6g/L (diatomite), under the conditions of 55 DEG C, decolouring 40min；
It is filtered to remove slag, obtain aloe gel juice；
4) aloe gel juice is concentrated in vacuo at 22 DEG C, concentrates 5 times；
5) aloe gel inspissated juice obtained by step 4) is freezed at a temperature of -30 DEG C, control water content is less than
6.0%, produce aloe barbadensis Miller full leaf dried powder.
The present embodiment provides a kind of aloe capsule simultaneously, takes above-mentioned 100 parts of aloe barbadensis Miller full leaf dried powder, crosses 100 mesh
Sieve, filling No. 1 capsule, packaging, obtain finished product.
Embodiment 2
The present embodiment provides a kind of aloe capsule, 100 parts of the gained aloe barbadensis Miller full leaf dried powder of Example 1, crosses 100 mesh
Sieve, filling No. 0 capsule, packaging, obtain finished product.
Embodiment 3
The present embodiment provides a kind of aloe capsule, 100 parts of the gained aloe barbadensis Miller full leaf dried powder of Example 1, crosses 100 mesh
Sieve, filling No. 00 capsule, packaging, obtain finished product.
Test example 1
It is as follows using testing by having been carried out for 20 overweight peoples：
According to obese degree and the requirement to lose weight, the capsule prepared by Example 13 times a day, 1 tablet each time, is eaten
After take.
By 30 days tracking and testings, usual 1 course for the treatment of can take effect.Weight loss amount is minimum 3.3 kilograms, maximum decrement
8.9 kilogram.Average weight lowers 6.4 kilograms.
Subject eats and instructed by two courses for the treatment of, and weight loss amount is minimum 5.6 kilograms, and maximum decrement 14.0 is public
Jin, average weight decline 9.4 kilograms.
Test example 2
Experimental condition：
Sample：Aloe capsule described in embodiment 1, plastic bottle packing.Recommended daily dosage：4/day, 0.4g/ grains, proportionately
People's body weight 60kg is counted, i.e., recommended daily dosage is 0.027g/kg.b.w..Each test group concentration is made into drinking water dilution.
Dosage：Divide drinking water control group, Constipation Model control group and basic, normal, high three dosage groups, measure as follows：
Low dose group 0.13g/kg.b.w..
Middle dose group 0.27g/kg.b.w..
High dose group 0.81g/kg.b.w..
Animal：NIH kind small white mouses, 18-22 grams of 6-8 week old, body weight, male, provided by Guangdong Province medical animal field.It is qualified
Book probatio inspectionem pecuoarem 2001A044.Pellet is provided by Guangdong Province medical animal field.
Animal Lab.：Cleaning grade, qualified book Guangdong probatio inspectionem pecuoarem 2001C047 and the dynamic word 26-040 of doctor.25 ± 2 DEG C of room temperature；It is wet
Spend 60%-80%.
Instrument and reagent：Operating scissors, ophthalmic tweezers, ruler, balance, activated carbon powder, gum arabic, compound diphenoxylate
(state-run Wujin pharmaceutical factory, lot number 20000125).
Give tested material approach：Each dosage group diluted with drinking water after through mouth gavage, gavage amount is 0.2ml/10g.b.w.
Data processing：All data carry out statistical disposition with SPSS10.0 software kits.
Test method：
1. resisting diphenoxylate suppresses Intestinal pushing Experiment on Function
After animal is quarantined one week in laboratory conditions, 50 mouse are divided into five groups at random, every group 10, divide blank pair
According to group, Constipation Model control group, low, medium and high dosage group, daily gavage experimental period 10 days, gives sample amount root to given the test agent
Increase and decrease according to body weight weekly and adjust.After last day fasting 12 hours, Constipation Model control group and three dosage group gavages give fragrant promise
Ester 25mg/kg, 0.2ml/10g.b.w gavages are pressed with the carbon powder suspension containing sample after 10 minutes, after 20 minutes, put to death mouse and open
Abdomen, small intestine clip upper end is taken from pylorus the intestinal tube of lower end to ileocecus, small intestine suspention to be vertically in line, determines Length of intestine
For " total small intestinal length ", it is " prepared Chinese ink propulsion length " to calculate ink progradation from pylorus to black sweat forward position.
2. resist drug induced constipation experiment
50 mouse are divided into five groups at random, every group 10, divide blank control group, Constipation Model control group, low, medium and high
Dosage group, daily gavage give given the test agent, totally 10 days, are increased and decreased to sample amount according to body weight weekly and adjusted, each group mouse before experiment
Fasting 12 hours (free water therebetween), Constipation Model control group and three dosage groups, gavage are given diphenoxylate 25mg/kg, given
1 hour after diphenoxylate, control group gives carbon powder suspension, and sample sets give the carbon powder suspension containing sample by 0.2ml/10g, every
Mouse is individually fed, and observes and records every mouse defecation time first, 6h defecations grain number and defecation weight.
Experimental result
Influence to body weight
Starting weight, eventually weight and control group ratio from the visible high, medium and low dosage group mouse of aloe capsule of the present invention of table (1)
Compared with no significant difference (p ＞ 0.05).
Influence of the aloe capsule of table (1) embodiment 1 to mouse weight
The aloe capsule confrontation diphenoxylate that the embodiment of the present invention 1 provides suppresses Intestinal pushing Experiment on Function
The influence that the aloe capsule that the embodiment of the present invention 1 provides is acted on mouse Intestinal pushing is shown in Table (2), with giving compound fragrant
After promise ester, Constipation Model control group ink progradation is significantly lower than blank control group (P ＜ 0.01), i.e. mouse intestines suppress propulsion module
Type is set up.Each dosage group prepared Chinese ink recommendation rate significantly improves, and for low dose group compared with Constipation Model control group, difference has conspicuousness meaning
Adopted (P ＜ 0.05), for middle and high dosage group compared with Constipation Model control group, difference has pole significant (P ＜ 0.01), shows
The aloe capsule that the embodiment of the present invention 1 provides can resist intestines inhibitory action caused by diphenoxylate.
The influence that the aloe capsule that table (2) embodiment 1 provides is acted on Intestinal pushing
Note：F=8.209 * P ＜ 0.05**P ＜ 0.01 compared with Constipation Model control group；
The △ △ P ＜ 0.01 compared with blank control group
Drug induced constipation is tested
The aloe capsule confrontation drug induced constipation experiment that the embodiment of the present invention 1 provides, from table (3), gives fragrant promise
Ester causes Constipated mice to set up.Give the aloe capsule of the offer of the various dose embodiment of the present invention 1 10 days, hence it is evident that shorten first
Secondary defecation time, for low, middle dose group compared with Constipation Model group, difference has a pole significant (P ＜ 0.01), high dose group with
Constipation Model group is compared, and difference has significant (P ＜ 0.05).Increase mice with constipation defecation grain number and defecation weight simultaneously,
For low dose group defecation grain number compared with Constipation Model group, difference has significant (P ＜ 0.05)；Middle dose group defecation grain number with
Constipation Model group is compared, and difference has pole significant (P ＜ 0.01)；Middle dose group defecation weight compared with Constipation Model group,
Difference has significant (P ＜ 0.05), shows that the aloe capsule that the embodiment of the present invention 1 provides has improvement constipation effect.
Influence of the aloe capsule that table (3) embodiment 1 provides to drug induced constipation
(mean+SD)
Note：1st, * P ＜ 0.05, * * P ＜ 0.01 compared with Constipation Model control group are represented
2nd, △ △ P ＜ 0.01 compared with blank control group
Conclusion：
NIH kinds mouse is given respectively daily the embodiment of the present invention 1 offer aloe capsule 0.13,0.27,0.81g/
Kg.b.w. totally 10 days, the aloe capsule that as a result embodiment of the present invention 1 provides can resist Intestinal pushing caused by diphenoxylate and suppress to make
With；Shorten the defecation time first of Constipation Model mouse, increase defecation grain number and defecation weight.
The aloe capsule of the offer of the embodiment of the present invention 1 is provided with the embodiment of the present invention 2, the embodiment of the present invention 3 respectively, repeated
Above-mentioned human experiment experiment, acquired results omit without essential difference.
Evaluation of result：Foundation《Function of health food assessment process and the method for inspection》Functions of loosening bowel relieving constipation evaluation criterion is sentenced
Disconnected, the aloe capsule that the embodiment of the present invention 1 provides has improvement gastrointestinal function, functions of loosening bowel relieving constipation.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment
State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (8)
1. a kind of aloe capsule with function of relaxing bowel, it is characterised in that active component is aloe dry powder.
2. aloe capsule according to claim 1, it is characterised in that the aloe dry powder is that aloe barbadensis Miller full leaf is done
Powder.
3. aloe capsule according to claim 2, it is characterised in that the aloe dry powder is prepared by following methods：
1) by after the cleaned sterilization of Aloe Barbadensis Miller fresh leaf, peeling, aloe gel is obtained；
2) pectase is added into the aloe gel, obtains zymolyte；
The dosage of the pectase is 60-80ppm；
3) zymolyte obtained by step 2) is decolourized, filter and remove residue, obtains aloe gel juice；
4) aloe gel juice is concentrated more than 5 times；
5) it is aloe gel inspissated juice obtained by step 4) is freeze-dried, produce aloe barbadensis Miller full leaf dried powder.
4. aloe capsule according to claim 3, it is characterised in that the condition of the concentration is that vacuum is dense at 20-25 DEG C
Contracting.
5. the aloe capsule according to claim 3 or 4, it is characterised in that with the side of activated carbon and diatomite Joint adsorption
Method is decolourized to the zymolyte.
6. aloe capsule according to claim 5, it is characterised in that the decolouring refers to using 1.3 ± 0.5g/L activity
Charcoal and 1.6 ± 0.5g/L diatomite, under the conditions of 55 DEG C, to the zymolyte decolouring 40min.
7. according to the aloe capsule described in claim any one of 4-6, it is characterised in that the step 5) is：
It will be freezed at temperature of the aloe gel inspissated juice obtained by step 4) below -30 DEG C, control water content is less than
6.0%, produce aloe barbadensis Miller full leaf dried powder.
A kind of 8. method for the aloe capsule for preparing any one of claim 1-7, it is characterised in that take the aloe dry powder mistake
60-150 mesh sieves, filling No. 1-No. 00 capsule, are produced.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711242564.6A CN107801997A (en) | 2017-11-30 | 2017-11-30 | A kind of aloe capsule with function of relaxing bowel and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711242564.6A CN107801997A (en) | 2017-11-30 | 2017-11-30 | A kind of aloe capsule with function of relaxing bowel and preparation method thereof |
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| CN107801997A true CN107801997A (en) | 2018-03-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711242564.6A Pending CN107801997A (en) | 2017-11-30 | 2017-11-30 | A kind of aloe capsule with function of relaxing bowel and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108651930A (en) * | 2018-04-03 | 2018-10-16 | 西安市东瑞药业有限公司 | A kind of capsule health food containing and preparation method thereof for defaecation |
| CN109393459A (en) * | 2018-10-18 | 2019-03-01 | 安徽济生元药业有限公司 | A kind of aloe capsule of energy defaecation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1916064A (en) * | 2006-08-07 | 2007-02-21 | 杭州保灵养泰禾生物科技有限公司 | Dry powder of gelatinous polysaccharide of aloe, producing method and preparation |
| CN103720664A (en) * | 2013-12-13 | 2014-04-16 | 浙江泰康生物科技有限公司 | Preparing method for aloe vera gel dry powder |
| CN104547341A (en) * | 2014-12-31 | 2015-04-29 | 天津凯镛药业有限公司 | Aloe capsule and its preparation method |
-
2017
- 2017-11-30 CN CN201711242564.6A patent/CN107801997A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1916064A (en) * | 2006-08-07 | 2007-02-21 | 杭州保灵养泰禾生物科技有限公司 | Dry powder of gelatinous polysaccharide of aloe, producing method and preparation |
| CN103720664A (en) * | 2013-12-13 | 2014-04-16 | 浙江泰康生物科技有限公司 | Preparing method for aloe vera gel dry powder |
| CN104547341A (en) * | 2014-12-31 | 2015-04-29 | 天津凯镛药业有限公司 | Aloe capsule and its preparation method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108651930A (en) * | 2018-04-03 | 2018-10-16 | 西安市东瑞药业有限公司 | A kind of capsule health food containing and preparation method thereof for defaecation |
| CN109393459A (en) * | 2018-10-18 | 2019-03-01 | 安徽济生元药业有限公司 | A kind of aloe capsule of energy defaecation |
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Application publication date: 20180316 |
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