CN107754017A - Medical apparatus surface coating and application - Google Patents
Medical apparatus surface coating and application Download PDFInfo
- Publication number
- CN107754017A CN107754017A CN201610705592.6A CN201610705592A CN107754017A CN 107754017 A CN107754017 A CN 107754017A CN 201610705592 A CN201610705592 A CN 201610705592A CN 107754017 A CN107754017 A CN 107754017A
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- China
- Prior art keywords
- coating
- medical apparatus
- apparatus surface
- polymer
- surface coating
- Prior art date
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- Granted
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- 239000011248 coating agent Substances 0.000 title claims abstract description 100
- 238000000576 coating method Methods 0.000 title claims abstract description 100
- 229920000642 polymer Polymers 0.000 claims abstract description 22
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 13
- 150000008064 anhydrides Chemical class 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 6
- 238000004132 cross linking Methods 0.000 claims abstract description 4
- 239000004744 fabric Substances 0.000 claims abstract 2
- 238000000465 moulding Methods 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- -1 polyethylene pyrrole Polymers 0.000 claims description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 239000004952 Polyamide Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229940014800 succinic anhydride Drugs 0.000 claims description 4
- OFNISBHGPNMTMS-UHFFFAOYSA-N 3-methylideneoxolane-2,5-dione Chemical compound C=C1CC(=O)OC1=O OFNISBHGPNMTMS-UHFFFAOYSA-N 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical group O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 3
- 230000008023 solidification Effects 0.000 claims description 3
- YAXXOCZAXKLLCV-UHFFFAOYSA-N 3-dodecyloxolane-2,5-dione Chemical compound CCCCCCCCCCCCC1CC(=O)OC1=O YAXXOCZAXKLLCV-UHFFFAOYSA-N 0.000 claims description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 235000004443 Ricinus communis Nutrition 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 238000003860 storage Methods 0.000 abstract description 16
- 230000008859 change Effects 0.000 abstract description 14
- 239000007788 liquid Substances 0.000 abstract description 8
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract description 3
- 229920000180 alkyd Polymers 0.000 abstract description 2
- 229920006037 cross link polymer Polymers 0.000 abstract description 2
- 239000004971 Cross linker Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 27
- 238000012360 testing method Methods 0.000 description 26
- 239000002245 particle Substances 0.000 description 18
- 239000000463 material Substances 0.000 description 13
- 239000011159 matrix material Substances 0.000 description 10
- 239000004814 polyurethane Substances 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000008199 coating composition Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000012948 isocyanate Substances 0.000 description 3
- 150000002513 isocyanates Chemical class 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 150000008065 acid anhydrides Chemical class 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000005056 polyisocyanate Substances 0.000 description 2
- 229920001228 polyisocyanate Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 206010042928 Syringomyelia Diseases 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/04—Coating
- C08J7/0427—Coating with only one layer of a composition containing a polymer binder
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2401/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
- C08J2401/02—Cellulose; Modified cellulose
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2439/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
- C08J2439/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08J2439/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2475/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2475/04—Polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2491/00—Characterised by the use of oils, fats or waxes; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to medical instruments field, and in particular to medical apparatus surface coating and application.The coating includes hydrophilic polymer, polyhydroxylated polymer, anhydrides crosslinking agent and decentralized medium, and the polyhydroxylated polymer includes at least two cross-linking terminal hydroxy groups.A kind of forming method of coating includes configuring the medical apparatus surface coating；The coating cloth of configuration is imposed on into medical apparatus surface and curing molding.Technical scheme provided by the invention is to form hydrophilic polymer and alkyd cross-linked polymer IPN in medical apparatus surface, the coating of formation is in liquid environment, at least one characteristic of lubricity, fastness and antistatic property increases, because anhydrides cross linker active is appropriate, therefore system is relatively stable, is adapted to industrial operation and preservation, compared with prior art, after 20 frictional experiments, lubricity does not substantially reduce, and performance does not substantially change after storage for a long time.
Description
Technical field
The invention belongs to medical instruments field, and in particular to medical apparatus surface coating and application.
Background technology
Medical lubricant coating has relatively low skin-friction coefficient coated in medical apparatus surface, such as seal wire, PTCA conduits,
Catheter, endoscope etc., when insertion is with extracting, the friction of apparatus and body tissue is reduced, mitigates the pain of patient in art,
Doctor's operating difficulties, diseased region is cannot be introduced into because frictional resistance is big in face of harsh lesion.
In the prior art, table of the interventional medical apparatus under blood and organizational environment is reduced by coating lubricant coating
Face coefficient of friction, relatively effective mode is to carry out surface treatment to interventional medical apparatus to form hydrophilic coating, described hydrophilic
Coating aquation can form one layer of water-swellable gel rapidly in aqueous environment, be largely water in this water-swellable layer,
Liquid barrier is formed between apparatus and tissue, because fluid molecule Interaction Force is weaker, is appointed by eliminating in motion process
What solid directly shows to contact with solid, so as to significantly reduce the friction between surface and surface, alleviates to people
The damage of body tissue, and bring great convenience for interventional therapy operation operation.
For example patent US4119094 is mentioned using the mixed solution of solvent-based polyisocyanate and polyurethane as bottom substrates,
Contain unreacted isocyanate groups in solution, using the solution of polyvinylpyrrolidone as Topcoating solution, dry, 65 degree
Solidify 6 hours.Patent US4373009, patent EP0106004B1, using polyisocyanate ester solution as bottom substrates layer, its
In include unreacted isocyanate group, use can with isocyanates formed Covalent bonding together hydrophile copolymers for top painting
Layer.Solvent-based thermal plastic polyurethane and polyvinylpyrrolidone blend coating solution are used in patent US4642267, is applied
Afterwards, solidification obtains.
The coating mentioned in above-mentioned patent, it is hydrophilic common by the way that the top of Covalent bonding together can be formed with isocyanates
Polymers can firmly be attached to interventional medical equipment surfaces, but the reactivity of isocyanates is higher, and solution is not easy
Preserve, need to have used in a short time with postponing, be unsuitable in industrialized production, can only small lot use, low production efficiency
Under.
The content of the invention
The invention provides a kind of medical apparatus surface coating and application, is used to solve current medical apparatus surface
Paint stability is poor, the problem of being not easy industrial applications.
In order to solve the above-mentioned technical problem, the technical scheme is that：The medical apparatus surface coating, including parent
Waterborne polymeric, polyhydroxylated polymer, anhydrides crosslinking agent and decentralized medium, the polyhydroxylated polymer can including at least two
It is crosslinked terminal hydroxy group.
The hydrophilic polymer refers to (such as hydroxyl, carboxyl, amido and polyethylene oxide chain containing multiple hydrophilic radicals
Section) polymer, these polymer may be dissolved in water in the presence of hydrophilic radical.
Wherein, hydrophilic polymer is that coating forms main body；Polyhydroxylated polymer and the reaction of anhydrides crosslinking agent, after reaction
Product can cause whole coating to form crosslinking inierpeneirating network structure, hydrophilic polymer is attached to medical apparatus surface.
Further, the polyhydroxylated polymer is selected from cellulose and its derivates, hyperbranched polyol polyester, hyperbranched
Polyhydroxy polycarboxylic carboxylic acid amide esters, one or more of hyperbranched polyhydroxy polycarboxylic urethane and castor oil.
Further, the anhydrides crosslinking agent is selected from maleic anhydride, itaconic anhydride, succinic anhydride or dodecyl
One or more in succinic anhydride and polystyrene-maleic anhydride copolymer.
Further, the hydrophilic polymer is selected from polyethylene pyrrole network alkanone, polyoxyethylene or polyamide.
Further, the one kind of the decentralized medium in ethyl acetate, chloroform, dichloromethane, methanol, second alcohol and water
More than, preferred alcohol, water or ethanol water.
Further, the medical apparatus surface is as follows by weight percentage with coating each component：
Further, the percentage by weight of each component is as follows：
Present invention also offers a kind of forming method of coating, comprise the following steps：
Hydrophilic polymer, polyhydroxylated polymer, anhydrides crosslinking agent, decentralized medium are put into container, are mixed into homogeneous
Solution is completed after solution to prepare.The solution is imposed on into the medical apparatus surface by spraying, infiltrating or brush, is put into baking oven
At 90-130 DEG C, coating preparation is completed after solidifying 30-60 minutes.
Present invention also offers a kind of medicine equipment, the medical apparatus surface is attached with above-mentioned medical apparatus surface and applied
Material.
Present invention also offers a kind of hydrophilic coating of medical apparatus surface, the hydrophilic coating include waterborne polymeric,
Polyhydroxylated polymer and anhydrides crosslinking agent.
Technical scheme provided by the invention is to form hydrophilic polymer and alkyd cross-linked polymer in medical apparatus surface
IPN, in liquid environment, lubricity, at least one characteristic of fastness increase the coating of formation, because anhydrides are handed over
It is appropriate to join agent activity, therefore system is relatively stable, is adapted to industrial operation and preservation, compared with prior art, 20 frictions are real
After testing, lubricity does not substantially reduce, and performance does not substantially change after storage for a long time.
Embodiment
With reference to specific embodiment, technical scheme is expanded on further.It should be understood that these embodiments are only used for
Illustrate the present invention rather than limitation the scope of the present invention.The experimental method of unreceipted actual conditions in the following example, generally
According to normal condition, or according to the condition proposed by manufacturer, the reagent in unreceipted source is purchased in market in the following example
Commodity.
Medicine equipment involved in the present invention can be the apparatus or extracorporeal device to implant.The apparatus can be temporary in short term
When use, it is or long-term permanent implanted.In some embodiments, suitable apparatus is that those are generally used for losing for the rhythm of the heart
Tune, heart failure, valvular disease, angiosis, diabetes, sacred disease and deficiency disorder, plastic surgery, neurosurgery, tumour
Learn, ophthalmology and ENT operations provide medical treatment and/or the apparatus diagnosed.Medicine equipment involved in the present invention includes but is not limited to
Following equipment：Support, stent graft, the connector that coincide, synthesis paster, lead, electrode, pin, wire, conduit, sensor, hand
Art instrument, angiopoiesis ball, wound drain, isocon (shunt), pipe, transfusion cover simple (infusion sleeve), urine
Road intubation, bead, implant, blood oxygenation generator, pump, vascular graft, flush type intervention medicine box (vascular
Access port), heart valve, annuloplasty ring, suture, surgical clips, operation nail, artificial or electronic heart pacemaker, implantable defibrillator,
Nerve stimulator, plastic surgery apparatus, celiolymph isocon, implantable Teat pipette, vertebra cage, artificial intervertebral disc, the replacement of nucleus pulposus
Apparatus, syrinx, intra-ocular lens and any pipe used in Minimally Invasive Surgery.
Coating involved in the present invention can be combined by kinds of processes with the surface of medicine equipment, as dip-coating, spraying,
Washing, gaseous phase deposition, brushing, roller coat and other methods known in the art.
Coating involved in the present invention can be controlled in several ways when medicine equipment is combined to form hydrophilic coating
The thickness of coating processed：Change soak time, change pulling speed or change the viscosity and applying step of Hydrophilic coating formulation
Number.
The material of medical apparatus surface involved in the present invention can be that high polymer material can also be metal or alloy material
Material.The preferably copolymer of polyether sulfone, polyurethane, silicone, polyester, polyamide, polyethers, polyolefin and above-mentioned polymer.
The present invention discloses a kind of medical apparatus surface coating composition, and said composition includes：(1) hydrophilic polymer,
Such as polyethylene pyrrole network alkanone, polyoxyethylene, polyamide；(2) it is the polymer at least containing two hydroxyls containing general structure, it is such as fine
Tie up plain, hyperbranched polyhydroxylated polymer, castor oil etc.；(3) polymer containing general structure for acid anhydrides, such as maleic anhydride,
The polymer such as itaconic anhydride, succinic anhydride, dodecyl succinic anhydride.The coating composition forms master with hydrophilic polymer
Body, comprising hydrophilic radical be soluble in water or there are good water absorbing properties.General structure for acid anhydrides material and
General structure is that at least the polymer containing two hydroxyls is reactant, and it is mutual can make it that whole coating forms crosslinking for product after reaction
Network structure is worn, hydrophilic polymer is attached to medical apparatus surface.Solution each component is very stable, is not easy to react, molten
Liquid is easy to preserve.
The invention also discloses a kind of hydrophilic coating prepared by aforementioned coating composition, the hydrophilic coating can be by above-mentioned
Composition is coated in matrix surface after being sufficiently mixed with liquid medium, and hydrophilic coating is formed after solidification.
Hydrophilic coating forming method includes：Above-mentioned composition is placed in container.Liquid medium is added into said vesse,
Liquid medium can be ethanol or the mixture of water or second alcohol and water, ethyl acetate, chloroform, dichloromethane.Treat the group in container
After compound forms uniform solution with liquid medium, by solution spraying to matrix surface.Heating said solution, obtain being formed at matrix
The hydrophilic coating on surface.
Embodiment 1
The medical apparatus surface is as follows with coating 200mL each component：
Said components are well mixed in a reservoir, preserved stand-by.
Coating and curing are：The medical apparatus surface of embodiment 1 is sprayed on sample with coating, be heating and curing temperature
Spend for 90 DEG C, heat time 30min.
Comparative example 1
Coating and curing are：The medical apparatus surface of comparative example 1 is sprayed on sample with coating, be heating and curing temperature
Spend for 90 DEG C, heat time 30min.
Contrast experiment
After embodiment 1 and comparative example 1 are deposited into 1 month, 12 months and 24 months, by coating and curing in pebax
Coating is formed on sample, then carries out the test of 1 frictional force and 20 frictional force, to assess lubricated with coating after long-term storage
Whether have an impact with performance in terms of fastness, as a result as shown in table 1, the coating of embodiment 1 performance after the storage of 24 months
Without significant change, and the lubricity of embodiment 1 increases compared with comparative example 1, and 20 times frictional force does not also substantially rise, explanation
Coating is directly firmly bonded degree height, excellent durability with matrix.
Table 1 is the experimental data of lubricity and fastness after long-term storage：
Embodiment 2
The medical apparatus surface is as follows with coating 200mL each component：
Said components are well mixed in a reservoir, normal temperature preserves stand-by.Solution after above-mentioned storage 12 months is placed in
In tube-type receptacle, medical polyurethane (PU) material conduit will be intervened and immerse solution after 30 seconds, with 5cm/min speed from solution
Middle proposition, be put into 100 DEG C of curing oven 40min, obtain the conduit with hydrophilic coating, to conduit in water 1 frictional force and
20 friction testings, as shown in table 2.Storage 12 months after, coating for matrix still have extraordinary being firmly bonded property and
Greasy property.
Table 2 is the experimental data of the pipe friction power test of embodiment 2：
Particle test is carried out to the conduit for scribbling embodiment 2, significant change does not occur for coated microgranules, it was demonstrated that coating and conduit
It is firmly combined with, coating is still effective, and experimental data is shown in Table 3.
Table 3 is the experimental data of the conduit particle test of embodiment 2
| Particle number (number) | |
| Coating rear tube (can be tested) | 1560 |
| Coating rear tube (after December) | 1620 |
Embodiment 3
The medical apparatus surface is as follows with coating 200mL each component：
Said components are well mixed in a reservoir, preserved stand-by.
Coating and curing are：The medical apparatus surface of embodiment 3 is sprayed on sample with coating, be heating and curing temperature
Spend for 130 DEG C, heat time 1h.To conduit in water 1 frictional force and 20 friction testings, as shown in table 4, storage 12
After individual month, coating still has extraordinary being firmly bonded property and greasy property for matrix.
Table 4 is the experimental data of the pipe friction power test of embodiment 3：
Particle test (can with place 12 months after) is carried out to product after above-mentioned coating, coated microgranules do not occur substantially to become
Change, it was demonstrated that coating is still effective, and experimental result is shown in Table 5.
Table 5 is the experimental data of the conduit particle test of embodiment 3：
| Particle number (number) | |
| Coating rear tube (can be tested) | 1706 |
| Coating rear tube (placing 12 months)) | 1810 |
Embodiment 4
The medical apparatus surface is as follows with coating 200mL each component：
Said components are well mixed in a reservoir, normal temperature preserves stand-by.
Solution after above-mentioned storage 12 months is placed in tube-type receptacle, medical polyurethane (PU) material conduit will be intervened
Solution is immersed after 30 seconds, is proposed with 5cm/min speed from solution, is put into 100 DEG C of curing oven 40min, is obtained with parent
The conduit of water coating, to conduit in water 1 frictional force and 20 friction testings, as shown in table 6, storage 12 months after, apply
Material still has extraordinary being firmly bonded property and greasy property for matrix.
Table 6 is the experimental data of the pipe friction power test of embodiment 4：
Particle test (at once with place 12 months after) is carried out to product after above-mentioned coating, coated microgranules do not occur substantially to become
Change, it was demonstrated that coating is still effective, and experimental result is shown in Table 7.
Table 7 is the experimental data of the conduit particle test of embodiment 4：
| Particle number (number) | |
| Coating rear tube (is tested) at once | 1706 |
| Coating rear tube (placing 12 months)) | 1810 |
Embodiment 5
The medical apparatus surface is as follows with coating 200mL each component：
Said components are well mixed in a reservoir, normal temperature preserves stand-by.
Solution after above-mentioned storage 12 months is placed in tube-type receptacle, medical polyurethane (PU) material conduit will be intervened
Solution is immersed after 30 seconds, is proposed with 5cm/min speed from solution, is put into 100 DEG C of curing oven 40min, is obtained with parent
The conduit of water coating, to conduit in water 1 frictional force and 20 friction testings, as shown in table 8, storage 12 months after, apply
Material still has extraordinary being firmly bonded property and greasy property for matrix.
Table 8 is the experimental data of the pipe friction power test of embodiment 5：
Particle test (at once with place 12 months after) is carried out to product after above-mentioned coating, coated microgranules do not occur substantially to become
Change, it was demonstrated that coating is still effective, and experimental result is shown in Table 9.
Table 9 is the experimental data of the conduit particle test of embodiment 5：
| Particle number (number) | |
| Coating rear tube (is tested) at once | 1706 |
| Coating rear tube (placing 12 months)) | 1810 |
Embodiment 6
The medical apparatus surface is as follows with coating 200mL each component：
Said components are well mixed in a reservoir, normal temperature preserves stand-by.
Solution after above-mentioned storage 12 months is placed in tube-type receptacle, medical polyurethane (PU) material conduit will be intervened
Solution is immersed after 30 seconds, is proposed with 5cm/min speed from solution, is put into 100 DEG C of curing oven 40min, is obtained with parent
The conduit of water coating, to conduit in water 1 frictional force and 20 friction testings, as shown in table 10, storage 12 months after, apply
Material still has extraordinary being firmly bonded property and greasy property for matrix.
Table 10 is the experimental data of the pipe friction power test of embodiment 6
Particle test (at once with place 12 months after) is carried out to product after above-mentioned coating, coated microgranules do not occur substantially to become
Change, it was demonstrated that coating is still effective, and experimental result is shown in Table 11.
Table 11 is the experimental data of the conduit particle test of embodiment 6
| Particle number (number) | |
| Coating rear tube (is tested) at once | 1540 |
| Coating rear tube (placing 12 months)) | 1350 |
Embodiment 7
The medical apparatus surface is as follows with coating 200mL each component：
Said components are well mixed in a reservoir, normal temperature preserves stand-by.
Solution after above-mentioned storage 12 months is placed in tube-type receptacle, medical polyurethane (PU) material conduit will be intervened
Solution is immersed after 30 seconds, is proposed with 5cm/min speed from solution, is put into 100 DEG C of curing oven 40min, is obtained with parent
The conduit of water coating, to conduit in water 1 frictional force and 20 friction testings, as shown in table 12, storage 12 months after, apply
Material still has extraordinary being firmly bonded property and greasy property for matrix.
Table 12 is the experimental data of the pipe friction power test of embodiment 7：
Particle test (at once with place 12 months after) is carried out to product after above-mentioned coating, coated microgranules do not occur substantially to become
Change, it was demonstrated that coating is still effective, and experimental result is shown in Table 11.
Table 13 is the experimental data of the conduit particle test of embodiment 7：
| Particle number (number) | |
| Coating rear tube (is tested) at once | 1460 |
| Coating rear tube (is placed 12 months) | 1521 |
Technical scheme stable system provided by the invention, polyhydroxylated polymer and anhydride polymer have good stabilization
Property, functional group's torpescence is not susceptible to react in normal temperature, easily stored, is adapted to industrial operation and preservation.With prior art phase
Than having lubricity good, lubricity and fastness substantially do not change after storing for a long time.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not limited to the substantial technological content model of the present invention
Enclose, substantial technological content of the invention is broadly to be defined in the right of application, any technology that other people complete
Entity or method, if with the right of application defined in it is identical, also or a kind of equivalent change, will
It is considered as being covered by among the right.
Claims (11)
1. a kind of medical apparatus surface coating, it is characterised in that including hydrophilic polymer, polyhydroxylated polymer, anhydrides
Crosslinking agent and decentralized medium, the polyhydroxylated polymer include at least two cross-linking terminal hydroxy groups.
2. a kind of medical apparatus surface coating according to claim 1, it is characterised in that the polyhydroxylated polymer is selected from
Cellulose and its derivates, hyperbranched polyol polyester, hyperbranched polyhydroxy polycarboxylic carboxylic acid amide esters, hyperbranched polyhydroxy polycarboxylic urethane and castor
One or more in sesame oil.
3. a kind of medical apparatus surface coating according to claim 1, it is characterised in that the anhydrides crosslinking agent is selected from
Maleic anhydride, itaconic anhydride, succinic anhydride, the one of dodecyl succinic anhydride and polystyrene-maleic anhydride copolymer
Kind is a variety of.
4. a kind of medical apparatus surface coating according to claim 1, it is characterised in that the hydrophilic polymer is selected from
The one or more of polyethylene pyrrole network alkanone, polyoxyethylene or polyamide.
5. a kind of medical apparatus surface coating according to claim 1, it is characterised in that the decentralized medium is selected from acetic acid
One or more in ethyl ester, chloroform, dichloromethane, methanol, second alcohol and water, preferred alcohol, water or ethanol water.
A kind of 6. medical apparatus surface coating according to claim 1, it is characterised in that the weight of the coating each component
Percentage is as follows：
Preferable percentage by weight is as follows：
7. a kind of forming method of coating, it is characterised in that comprise the following steps：
1) any medical apparatus surface coating of claim 1-6 is configured；
2) the coating cloth that step 1) configures is imposed on into medical apparatus surface；
3) curing molding.
8. a kind of forming method of coating according to claim 7, it is characterised in that the step 3) curing is heating
Solidification.
9. a kind of forming method of coating according to claim 8, it is characterised in that the temperature that is heating and curing is 90-130
DEG C, the heat time is 30-60 minutes.
10. a kind of medicine equipment, it is characterised in that the medical apparatus surface is attached with any medical treatment of claim 1-6
Equipment surfaces coating.
A kind of 11. hydrophilic coating of medical apparatus surface, it is characterised in that, the hydrophilic coating includes waterborne polymeric, polyhydroxy
Based polyalcohol and anhydrides crosslinking agent.
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Effective date of registration: 20240914 Address after: No. 1601 Zhangdong Road, China (Shanghai) Pilot Free Trade Zone, Pudong New Area, Shanghai, 201210 Patentee after: SHANGHAI MICROPORT MEDICAL (GROUP) Co.,Ltd. Country or region after: China Address before: 201203 No. 1601, Zhangdong Road, Pudong New Area, Shanghai Patentee before: Minimally invasive Investment Holdings Ltd. Country or region before: China |