CN107737182A - A kind of Chinese medicine composition for treating cervical erosion and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating cervical erosion and preparation method thereof Download PDFInfo
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- CN107737182A CN107737182A CN201711327702.0A CN201711327702A CN107737182A CN 107737182 A CN107737182 A CN 107737182A CN 201711327702 A CN201711327702 A CN 201711327702A CN 107737182 A CN107737182 A CN 107737182A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating cervical erosion and preparation method thereof.The Chinese medicine is prepared by Chinese medicine materials such as nidus vespae, meadowrueleaf corydalis root, golden cypresses.Present invention also offers the preparation method of this Chinese medicine composition.Chinese medicine composition provided by the invention is mainly used in treating cervical erosion.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating cervical erosion and preparation method thereof.
Background technology
Cervical erosion is a kind of common gynecological disease, is a kind of form of expression of chronic cervicitis.Entitled erosion, it is actual
On, its not erosion, but the phenomenon replaced after cervical orifice excoriation by another epithelial tissue.
Cervical erosion is very thin due to the newborn epithelium of coverage rate, it might even be possible to sees the blood vessel of lower section and red group
Knit, it appears that just as really rotten to the corn, therefore referred to as cervical erosion.
The cervical erosion category traditional Chinese medical science " vaginal discharge diseases " category.It can be attributed to following three type by the pathogenesis of cervical erosion：
First, it is insufficiency of the spleen damp and hot：Because of eating and drinking without temperance, overstrain, temper is damaged, transformation failure of spleen, the wet bet of water, is injured conception vessel and is band
Under；Also have because of the insufficiency of the spleen with overabundance of dampness, counter to insult edema with the liver involved, liver depression heating, damp invasion of lower energizer and cause person.
2nd, kidney deficiency is damp and hot：Or factor body deficiency of kidney-QI, insufficiency of kidney-QI, or because of excess of sexual intercourse,indulgence in sexual activities, injure nephrons, lose dai channel
About, conception vessel is not solid, causes then under band.
3rd, damp and hot wet poison：Through row postpartum, vessels of the uterus is hollow, or because operation wound, the heresy of wet poison are taken advantage of a weak point, band is appointed in damage
Two arteries and veins and be band under.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating cervical erosion；
It is a further object of the present invention to provide a kind of preparation method for the Chinese medicine composition for treating cervical erosion.
The purpose of the present invention is realized by following technical scheme：
The Chinese medicine composition for the treatment of cervical erosion of the present invention, is prepared by the Chinese medicine material of following parts by weight：
Nidus vespae 10-30 parts, meadowrueleaf corydalis root 20-40 parts, golden cypress 10-30 parts.
Preferably, it is to be prepared by the Chinese medicine material of following parts by weight：
Nidus vespae 15-25 parts, meadowrueleaf corydalis root 25-35 parts, golden cypress 15-25 parts.
It is the crude drug source of Chinese medicine preparation of the present invention below：
Nidus vespae is Vespidae insect hornet or belongs to the nest of nearly edge insect together.It is sweet, put down.Enter liver, lung two pass through.Wind-dispelling, poison is attacked,
Desinsection.Control frightened epilepsy, wandering arthritis, urticaria itch, acute mastitis, serious case of furuncle, scrofula, anal fistula, acute toothache, favus of the scalp, honeybee stings swollen pain.
Meadowrueleaf corydalis root, Corydalis saxicola Bunting, for the root of bloodroot meadowrueleaf corydalis root, adopt after autumn.Bitter,
It is cool in nature.It is clearing heat and detoxicating, dampness removing, analgesic hemostatic.
Golden cypress, it is rutaceae wampee Phellodendron chinense Schneid. dry bark.Practise and claiming
" CORTEX PHELLODENDRI CHINENSE ".After stripping bark, tertia is removed, is dried.【Nature and flavor and channel tropism】Hardship, tremble with fear.Return kidney, bladder warp.【Function is with curing mainly】
Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted,
Hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing Yin and falling fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and this method is to use
The extraction of the ethanol of water extraction or 40-80% concentration expressed in percentage by volumes is prepared.Specific preparation method is as follows：
Scheme one：Take whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water equivalent to 6-12 times of medicinal material gross weight,
Each extraction time is 1-3 hours, merges extract solution, filtration, relative density is 1.15-1.20 when filtrate is concentrated into 70-80 DEG C
Clear cream, produce active component.
Scheme two：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption is medicinal material total amount
4-10 times, extraction time is 1-4 hours, merge extract solution, filtering, relative density is when filtrate is concentrated into 70-80 DEG C
1.15-1.20 clear cream, produces active component.
Scheme three：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, 6- of each amount of water equivalent to medicinal material gross weight
12 times, each extraction time is 1-3 hours, merges extract solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C
1.15-1.20 clear cream, ethanol is added, it is 40-70% to make alcohol content, stands 12-24 hours, and filtration, filtrate is concentrated into 70-80
DEG C when relative density be 1.10-1.25 medicinal extract, produce active component.
The Chinese medicine composition for the treatment of cervical erosion of the present invention, can also match somebody with somebody with pharmaceutically acceptable carrier
Close, various oral formulations, such as pill, tablet, capsule, oral liquid, syrup, mixture are made.
The pharmaceutically acceptable carrier of the present invention includes but is not limited to following：
Oral formulations：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1：Tablet
Scheme one is taken to add tablet and often use auxiliary material one of to the gained active component of scheme three, routinely production method is prepared into
Invention tablet.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 2：Capsule
Scheme one is taken to add capsule and often use auxiliary material, routinely production method is prepared into one of to the gained active component of scheme three
Capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 3：Syrup
Scheme one is taken to add syrup and often use auxiliary material, routinely production method is prepared into one of to the gained active component of scheme three
Syrup of the present invention.
Above-mentioned syrup often includes one of flavouring, preservative, cosolvent or whole with auxiliary material.
Method 4：Mixture
Scheme one is taken to add mixture and often use auxiliary material one of to the gained active component of scheme three, routinely production method is prepared into
Invention mixture.
Above-mentioned mixture often includes one of flavouring, preservative or whole with auxiliary material.
Method 5：Oral liquid
Scheme one is taken dissolving after-purification, concentration, to add oral liquid and often use auxiliary material, by normal one of to the gained active component of scheme three
Rule production method is prepared into oral liquid of the present invention.
The application be inventor under the guidance of theory of traditional Chinese medical science, formed with reference to clinic diagnosis empirical side for many years, although
Only three taste medicinal materials, but each medicinal material cooperates in side, complements each other：The main wind-dispelling of nidus vespae, and desinsection；Meadowrueleaf corydalis root master disappears
Inflammation, and dampness removing analgesic；The main eliminating dampness of golden cypress, and toxin expelling；The main function of ingredients and simultaneous control are arranged in pairs or groups very reasonable, to palace
The treatment of neck erosion patients from outward appearance to inner essence, from inside to outside, from the various causes of disease of cervical erosion, forms one by curing mainly simultaneous control
The treatment net of mutual cooperation, dispelling wind and eliminating dampness, the work(of eliminating inflammation and expelling toxin are played altogether.
A kind of Chinese medicine composition for treating cervical erosion provided by the invention has advantages below：
1st, composite preparation provided by the invention is safe and effective, and full side cooperates, and plays dispelling wind and eliminating dampness altogether, the work(of eliminating inflammation and expelling toxin,
Treatment total effective rate to cervical erosion is 95.3%..
2nd, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, in good taste, and cost is low.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate
The present invention rather than limitation of the present invention.The present invention is belonged to according to the simple modifications that the essence of the present invention is carried out to the present invention
Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
The tablet of embodiment 1
Weigh nidus vespae 10g, meadowrueleaf corydalis root 20g, golden cypress 10g.Extracting in water 3 times, amount of water is respectively medicinal material gross weight three times
12 times, 8 times, 6 times, extraction time is respectively 3 hours, 2 hours, 1 hour three times, merges extract solution, filtration, and filtrate is concentrated into 70
DEG C when relative density be 1.25 clear cream, add supplementary product starch, ethanol, talcum powder, be made tablet.
The granule of embodiment 2
Weigh nidus vespae 30g, meadowrueleaf corydalis root 40g, golden cypress 30g.Extracted 2 times with alcohol reflux, each concentration of alcohol is respectively 80%,
60%, each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, and extraction time is respectively 4 hours, 3 hours, merges extraction
Liquid, filtering, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, adds starch, dextrin, and granulation, dry, whole grain are
.
The syrup of embodiment 3
Weigh nidus vespae 15g, meadowrueleaf corydalis root 25g, golden cypress 15g.Extracting in water 2 times, each amount of water is respectively equivalent to medicinal material gross weight
12 times, 10 times of amount, each extraction time is respectively 3 hours, 2 hours, merges extract solution, filtration, and filtrate is concentrated at 80 DEG C
Relative density is 1.05 clear cream, adds ethanol, and it is 70% to make alcohol content, stands 12 hours, filtration, when filtrate is concentrated into 70 DEG C
Relative density is 1.25 medicinal extract, and syrup auxiliary material sucrose, sorbic acid, water are added in medicinal extract and is stirred, syrup is made.
The capsule of embodiment 4
Weigh nidus vespae 25g, meadowrueleaf corydalis root 35g, golden cypress 25g.Extracted 3 times with 40% alcohol reflux, each ethanol consumption is respectively medicine
10 times, 8 times, 4 times of material total amount, extraction time are distinguished 3 hours, 2 hours, 1 hour, merge extract solution, filtering, filtrate concentration 60
DEG C when relative density be 1.25 medicinal extract, in medicinal extract add supplementary product starch, ethanol, dextrin, magnesium stearate, make according to a conventional method
Into capsule.
The granule of embodiment 5
Weigh nidus vespae 20g, meadowrueleaf corydalis root 30g, golden cypress 20g.Extracting in water 2 times, amount of water is respectively medicinal material gross weight twice
10 times, 8 times, extraction time is respectively 2 hours, 1 hour twice, merges extract solution, filtration, filtrate is concentrated into relatively close at 80 DEG C
Spend the medicinal extract for 1.10.Starch, dextrin are added, granulation, dry, whole grain produce.
The tablet of embodiment 6
Weigh nidus vespae 12g, meadowrueleaf corydalis root 23g, golden cypress 12g.Extracting in water 3 times, three times amount of water be respectively equivalent to medicinal material gross weight
12 times, 8 times, 6 times of amount, each extraction time are distinguished 3 hours, 2 hours, 1 hour, merge extract solution, filtration, and filtrate is concentrated into
Relative density is 1.20 clear cream at 70 DEG C, adds ethanol, and it is 40% to make alcohol content, stands 24 hours, and filtration, filtrate is concentrated into
Relative density is 1.10 medicinal extract when filtrate is concentrated into 70 DEG C, adds supplementary product starch, ethanol, talcum powder, and tablet is made.
The mixture of embodiment 7
Weigh nidus vespae 18g, meadowrueleaf corydalis root 28g, golden cypress 18g.Extracting in water 3 times, three times amount of water be respectively equivalent to medicinal material gross weight
12 times, 8 times, 6 times of amount, each extraction time are distinguished 3 hours, 2 hours, 1 hour, merge extract solution, filtration, and filtrate is concentrated into
Gross weight is 3 times of medicinal material gross weight, filling, adds mixture auxiliary material sucrose, ethyl ester, water, sorbic acid and stirs, is made and closes
Agent.
The oral liquid of embodiment 8
Weigh nidus vespae 23g, meadowrueleaf corydalis root 32g, golden cypress 23g.Extracting in water 2 times, amount of water is respectively medicinal material gross weight twice
10 times, 8 times, extraction time is respectively 2 hours, 1 hour twice, merges extract solution, filtration, filtrate is concentrated into relatively close at 80 DEG C
The medicinal extract for 1.10 is spent, auxiliary material mannitol, sorbic acid, water are added in medicinal extract and is stirred, is dispensed, oral liquid is made.
The pulvis of embodiment 9
Weigh nidus vespae 28g, meadowrueleaf corydalis root 38g, golden cypress 28g.Crush, sieving, produce.
Clinical test is summarized
1 basic document
Patients of cervical ruin 64 is observed, the range of age is -45 years old 24 years old.Statistics inclusion criteria：It is all to include research
Data object clinical diagnosis result meets《Gynecotokology》In to the diagnostic criteria of cervical erosion disease.
2 treatment methods
Give the Granules in Treating of the embodiment of the present invention 5, each 10g, 3 times a day orally.2 months are a course for the treatment of, during treatment
Inside forbid bath in a tub, sexual intercourse and vaginadouche, keep perineum clear.It can be taken the circumstances into consideration to treat 1~2 course for the treatment of according to the specific state of an illness of patient.
3 curative effect judging standards
Recovery from illness：Patient after treatment, abnormal leucorrhea increases, uterine neck pain and bladder inflammation reaction etc. clinical manifestation be wholly absent
Person；
Effectively：Above clinical symptoms are obviously improved；
It is invalid：The clinical symptoms person of being not improved.
4 the results are shown in Table 1.
The efficacy result of table 1
| Recovery from illness | Effectively | It is invalid | It is efficient（%） | |
| Curative effect | 32 | 29 | 3 | 95.3 |
Clinical effectiveness is shown：The present invention is 95.3% to the total effective rate of patients of cervical ruin, the results showed that, the present invention has well
Treatment cervical carcinoma the effect of.
Model case
King XX, female, 45 years old.Patient tells marriage 12 years, gives birth to a sub female, nearly 1 year profuse leukorrhea, color yellowish-white half a year, without outer
Cloudy itch, no stomachache, eumenorrhea, pink tongue, tongue is thin white, small and wiry pulse.Gynecologial examination vulva is normal, and vaginal fluid is more, color
Yellowish-white, cervix moderate is rotten to the corn, and palace body anteposition, size activity is normal, and bilateral annex is normal.The embodiment of the present invention 4 is given to treat,
Check that cervical erosion face is repaired substantially after 3 months.
Beam XX, female, 28 years old.Patient's pedestrian stream art the year before, postoperative occur more with lower amount, and color is yellow, goes out occasionally after sexual intercourse
Blood.Gynecologial examination vulva is normal, and vaginal fluid is more, and cervix severe is rotten to the corn, and position after the body of palace, size activity is normal, and bilateral is attached
Part is normal.Give the embodiment of the present invention 7 to treat, medication is checked for 3 months, and uterine neck is smooth.
Claims (7)
- A kind of 1. Chinese medicine composition for treating cervical erosion, it is characterised in that it be by following parts by weight Chinese medicine material prepare and Into：Nidus vespae 10-30 parts, meadowrueleaf corydalis root 20-40 parts, golden cypress 10-30 parts.
- 2. the Chinese medicine composition for the treatment of cervical erosion as claimed in claim 1, it is characterised in that it is by including following weight What the Chinese medicine material of part was prepared：Nidus vespae 15-25 parts, meadowrueleaf corydalis root 25-35 parts, golden cypress 15-25 parts.
- 3. the Chinese medicine composition for the treatment of cervical erosion as claimed in claim 1 or 2, it is characterised in that its active component is to adopt It is prepared with the extraction of the ethanol of water extraction or 40-80% concentration expressed in percentage by volumes.
- 4. the Chinese medicine composition for the treatment of cervical erosion as claimed in claim 3, it is characterised in that its active component is to pass through What following methods were prepared：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight 6-12 times, each extraction time is 1-3 hours, merge extract solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C 1.15-1.20 clear cream, produces active component.
- 5. the Chinese medicine composition for the treatment of cervical erosion as claimed in claim 3, it is characterised in that its active component is to pass through What following methods were prepared：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption is 4-10 times of medicinal material total amount, extraction time are 1-4 hours, merge extract solution, filtering, filtrate is concentrated into relatively close at 70-80 DEG C The clear cream for 1.15-1.20 is spent, produces active component.
- 6. the Chinese medicine composition for the treatment of cervical erosion as claimed in claim 3, it is characterised in that its active component is to pass through What following methods were prepared：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight 6-12 times, each extraction time is 1-3 hours, merge extract solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C 1.15-1.20 clear cream, ethanol is added, it is 40-70% to make alcohol content, stands 12-24 hours, and filtration, filtrate is concentrated into 70-80 DEG C when relative density be 1.10-1.25 medicinal extract, produce active component.
- 7. a kind of preparation for treating cervical erosion, Chinese medicine composition and doctor as the treatment cervical erosion described in claim 1-6 Pharmaceutically acceptable carrier, which prepares, to be formed.
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| US20050112218A1 (en) * | 2001-12-12 | 2005-05-26 | ALEXIS Brian | Treatment of vulvovaginitis with spirostanol enriched extract from Tribulus Terrestris |
| CN101143174A (en) * | 2006-09-11 | 2008-03-19 | 刘永斌 | Traditional Chinese medicine formula for treating cervical erosion |
| CN106421165A (en) * | 2016-11-02 | 2017-02-22 | 杨均初 | Traditional Chinese medicine composition for treating pruritus vulvae, and preparation method thereof |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112218A1 (en) * | 2001-12-12 | 2005-05-26 | ALEXIS Brian | Treatment of vulvovaginitis with spirostanol enriched extract from Tribulus Terrestris |
| CN101143174A (en) * | 2006-09-11 | 2008-03-19 | 刘永斌 | Traditional Chinese medicine formula for treating cervical erosion |
| CN106421165A (en) * | 2016-11-02 | 2017-02-22 | 杨均初 | Traditional Chinese medicine composition for treating pruritus vulvae, and preparation method thereof |
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Application publication date: 20180227 |