CN107737033A - A kind of quick anti-acne and anti-acne print composition and preparation method thereof - Google Patents
A kind of quick anti-acne and anti-acne print composition and preparation method thereof Download PDFInfo
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- CN107737033A CN107737033A CN201710889517.4A CN201710889517A CN107737033A CN 107737033 A CN107737033 A CN 107737033A CN 201710889517 A CN201710889517 A CN 201710889517A CN 107737033 A CN107737033 A CN 107737033A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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Abstract
The invention discloses a kind of quick anti-acne and anti-acne to print composition, by weight, including following component：1.2 1.8 parts of salicylic acid；2.77 parts of arginase 12；Must 0.5 2 parts of extractive of usnea；1 10 parts of glabridin liposome；0.03 0.1 parts of 5 alcohol of O cymenes；1 12 parts of other acne-removing compositions；75 90 parts of other base-materials.The present invention is by the way that the arginine of the salicylic acid certain content of certain content is neutralized, compound the palpus extractive of usnea of certain content and the glabridin liposome of certain content, and it is aided with the alcohol of O cymenes 5 as gentle effective anticorrosion and bactericidal agent, other acne-removing compositions are added again into other base-materials, quick anti-acne and anti-acne the print composition being prepared have excellent acne-removing, while have the effect of good prevention acne print and anti-acne print.
Description
Technical field
The present invention relates to cosmetic field, more particularly to a kind of quick anti-acne and anti-acne print composition and preparation method thereof.
Background technology
Acne is commonly called as whelk, dark sore, acne, is a kind of infective inflammation of pilosebaceous follicle.Small pox produces inherent former
Because mainly having：（1）Endocrinopathy, smegma are active；（2）The disorder of digestive function：Such as higher fatty acid and high-carbon hydrate
Thing etc.；（3）Micro- deficiency：Such as VitAVitE insufficiency of intake.Mainly there is transient cause caused by small pox：（1）
Skin water oil is uneven, hence it is evident that fuel-displaced, the lubricant component such as free fatty do not cleared up in time easily triggers scytitis；（2）Hair
Bag hole keratinization is hyperfunction, blocks pore；（3）Bacterium factors etc..
Although acne-eliminating cosmetic now containing salicylic acid and above-mentioned some active matters has certain acne-removing, but its
Prevent that the effect of acne print and anti-acne print is undesirable, and its system pH is generally below 5.5 in addition, often to the excitant of skin compared with
Greatly.
The content of the invention
It is contemplated that provide a kind of work(that there is good acne-removing, while there is good prevention acne print and anti-acne print
Effect, and have the acne-removing composition of good mildness.
Quick anti-acne and anti-acne print composition of the present invention, by weight, including following component：
Salicylic acid 1.2-1.8 parts；
- 2.77 parts of arginase 12；
Must extractive of usnea 0.5-2 parts；
Glabridin liposome 1-10 parts；
The alcohol 0.03-0.1 parts of O- cymenes -5；
Other acne-removing composition 1-12 parts；
Other base-materials 75-90 parts.
Wherein, other described acne-removing compositions, including following component：
Niacinamide 1-5 parts；
Ethanol 1-5 parts.
Wherein, the glabridin liposome is the liposome body aqueous solution formed by phosphatide technique for packing；Institute
The glabridin content for stating glabridin liposome is 2000-3000ppm；It is this scope only when controlling licoricidin content,
The glabridin liposome just has the characteristics that toxicity is lower, skin-friendly is more preferable, permeability is stronger, makes the production of addition said composition
There is product good anti-acne to print effect.
Wherein, the alcohol of O- cymenes -5 is the alcohol crystals of O- cymenes -5 of purity >=95%, as gentle effective anti-corrosion
Bactericide is small to skin irritation.
Wherein, other described base-materials include water 65-75 parts by weight, carbomer 0.1-0.6 parts by weight, xanthans 0.05-0.3
Parts by weight, cetostearyl alcohol 1-5 parts by weight, ring five dimethyl silicone polymer/cyclohexasiloxane 1-5 parts by weight, caprylic/capric are sweet
Oily three ester 1-5 parts by weight, stearine/PEG-100 stearate 1-5 parts by weight, stearine SE 0.1-1
Parts by weight.
In addition, the invention also discloses above-mentioned quick anti-acne and the preparation method of anti-acne print composition, comprise the following steps：
1）Salicylic acid and arginine are added afterwards completely according to the heating predissolve of corresponding proportioning water and stirred evenly；
2）Niacinamide in palpus extractive of usnea, glabridin liposome and other acne-removing compositions is pre- according to proportioning water
Add and stir evenly after dissolving completely；
3）Ethanol predissolve in the alcohol of O- cymenes -5 and other acne-removing compositions is added afterwards completely and stirred evenly；
4）Then other base-materials are added to stir evenly, are produced.
Compared with prior art, the present invention has the advantages that：
By the way that the arginine of the salicylic acid certain content of certain content is neutralized, the palpus sunglo for compounding certain content carries the present invention
Thing and the glabridin liposome of certain content are taken, and is aided with the alcohol of O- cymenes -5 as gentle effective anticorrosion and bactericidal agent, then
Other acne-removing compositions are added into other base-materials, quick anti-acne and anti-acne the print composition being prepared have excellent anti-acne
Effect, while there is the effect of good prevention acne print and anti-acne print.
Embodiment
The present invention is further illustrated below by embodiment, following examples are the preferable embodiment party of the present invention
Formula, but embodiments of the present invention are not limited by following embodiments.
The method of testing and evaluation criterion of each performance indications：
The method of testing or evaluation method of acne-removing：
Tested crowd：Face substantially has small pox
Tested number：20-30 people
Position on probation：Face, the position of particularly long acne
Application method：After morning and evening face cleaning, appropriate given the test agent is taken to be applied to face, particularly long acne and the position for having acne print, gently
Forlement extremely absorbs
Usage time：0-8W
Evaluation method：Pass through skin surface part analyzer VISIA CR（Canfield, the U.S.）With face-image analysis software
Image-Pro Plus（Media Cybernetics, Inc.）Photographic analysis is carried out before on probation to subject and after use, is counted
Calculate inflammatory papules number per capita or the per capita decrement of warts number；If 80% or more is reduced, to be excellent；If reduce 60%-
80%, then to be good；If 40%-60% is reduced, preferably；If less than 40% is reduced, to be poor.
Anti-acne prints the method for testing or evaluation method of effect：Pass through skin surface part analyzer VISIA CR（Canfield is beautiful
State）With face-image analysis software Image-Pro Plus（Media Cybernetics, Inc.）Before on probation to subject and
Photographic analysis is carried out after use, acne print eliminates quantity or desalination degree after visual observations analysis small pox anti-inflammatory, and has acne originally
Acne print eliminates quantity or desalination degree after the position of print uses product；If not leaving acne print after 80% or more small pox anti-inflammatory,
Or there is the position 80% of acne print or more acne print all to eliminate originally, then to be excellent；If do not left after 60%-80% small pox anti-inflammatory
Acne print leaves behind very shallow acne print, or the position 60%-80% acne prints for having acne print originally all eliminate or left behind very slight color
Acne print, then to be good；If not leaving acne print after 40%-60% small pox anti-inflammatory or leaving behind very shallow acne print, or there is acne originally
The position 40%-60% acne prints of print all eliminate or left behind the acne print of very slight color, then preferably；If less than 40% small pox anti-inflammatory
Do not leave acne print afterwards or leave the obvious acne print of color, or the position acne print below 40% for having acne print originally eliminates or left face
The obvious acne print of color, then to be poor.
The method of testing of the pH value of system： GB/T 13531.1；
The method of testing or evaluation method of mildness：
Tested crowd：Face substantially has small pox
Tested number：20-30 people
Position on probation：Face, particularly long acne and the position for having acne print
Application method：After morning and evening face cleaning, appropriate given the test agent is taken to be applied to face, particularly long acne and the position for having acne print, gently
Forlement extremely absorbs；
Evaluation method：
1st, using in sample or using after sample 0-15 minutes, if having obvious thorn, heat, itching or the stimulate the reaction such as pain, comment
For obvious stimulation；If having slight thorn, heat, itching or the minor response such as pain, minimal irritation is chosen as；If completely it is stingless, hot, itch or pain
Etc. stimulate the reaction, then it is chosen as non-stimulated.（All embodiments and comparative example are using the method evaluation excitant）
2nd, patch test method：Device is tried from suitable patch, with closed patch experimental method, tested material about 0.03ml is applied to
In spot examination device, external application special adhesive tape is pasted on subject back, and tested material is removed after 24 hours, 0.5 after patch experiment,
24th, observation dermoreaction in 48 hours, is pressed《Cosmetics safety technical specification》（Version in 2015）Middle dermoreaction grade scale record
Its result.（Embodiment 1 and embodiment 6 are also tested in addition to using above-mentioned first method evaluation excitant by patch test method
Card, as a result for without any adverse reaction.）
Embodiment 1-6 and comparative example 1-6：The preparation of quick anti-acne and anti-acne print composition
Niacinamide in salicylic acid, arginine, palpus extractive of usnea, glabridin liposome and other acne-removing compositions is pressed
Add and stir evenly afterwards completely according to the predissolve of proportioning water；The alcohol of O- cymenes -5 and the ethanol in other acne-removing compositions is pre-
Add and stir evenly after dissolving completely；Then other base-materials are added to stir evenly, produce quick anti-acne and anti-acne print composition.Gained is fast
The system pH of fast anti-acne and anti-acne print composition, acne-removing, that anti-acne prints the performance indications such as effect and mildness is as shown in table 1.
The embodiment 1-6 of table 1 and comparative example 1-6 each group distribution ratio and each testing performance index result
Continued 1
。
Claims (6)
1. a kind of quick anti-acne and anti-acne print composition, it is characterised in that by weight, including following component：
Salicylic acid 1.2-1.8 parts；
- 2.77 parts of arginase 12；
Must extractive of usnea 0.5-2 parts；
Glabridin liposome 1-10 parts；
The alcohol 0.03-0.1 parts of O- cymenes -5；
Other acne-removing composition 1-12 parts；
Other base-materials 75-90 parts.
2. quick anti-acne according to claim 1 and anti-acne print composition, it is characterised in that other described acne-removings into
Part includes following component：
Niacinamide 1-5 parts；
Ethanol 1-5 parts.
3. quick anti-acne according to claim 1 and anti-acne print composition, it is characterised in that the glabridin liposome
For the liposome body aqueous solution formed by phosphatide technique for packing；The glabridin content of the glabridin liposome is
2000-3000ppm。
4. quick anti-acne according to claim 1 and anti-acne print composition, it is characterised in that the alcohol of O- cymenes -5 is
The alcohol crystals of O- cymenes -5 of purity >=95%.
5. quick anti-acne according to claim 1 and anti-acne print composition, it is characterised in that other described base-materials include water
65-75 parts by weight, carbomer 0.1-0.6 parts by weight, xanthans 0.05-0.3 parts by weight, cetostearyl alcohol 1-5 parts by weight, ring five
Dimethyl silicone polymer/cyclohexasiloxane 1-5 parts by weight, caprylic/capric triglyceride 1-5 parts by weight, stearine/
PEG-100 stearate 1-5 parts by weight, stearine SE 0.1-1 parts by weight.
6. a kind of preparation method of quick anti-acne and anti-acne print composition as described in claim any one of 1-5, its feature exist
In comprising the following steps：
1）Salicylic acid and arginine are added afterwards completely according to the heating predissolve of corresponding proportioning water and stirred evenly；
2）Niacinamide in palpus extractive of usnea, glabridin liposome and other acne-removing compositions is pre- according to proportioning water
Add and stir evenly after dissolving completely；
3）Ethanol predissolve in the alcohol of O- cymenes -5 and other acne-removing compositions is added afterwards completely and stirred evenly；
4）Then other base-materials are added to stir evenly, are produced.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710889517.4A CN107737033A (en) | 2017-09-27 | 2017-09-27 | A kind of quick anti-acne and anti-acne print composition and preparation method thereof |
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| CN201710889517.4A CN107737033A (en) | 2017-09-27 | 2017-09-27 | A kind of quick anti-acne and anti-acne print composition and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112006934A (en) * | 2020-09-04 | 2020-12-01 | 江苏美爱斯化妆品股份有限公司 | Cosmetic compound with mild acne removing effect and application thereof |
| CN114224810A (en) * | 2021-12-31 | 2022-03-25 | 湖南亚大丰晖新材料有限公司 | Preparation method and application of novel water-soluble acne-removing composite material |
| CN115844796A (en) * | 2022-12-27 | 2023-03-28 | 陕西慧康生物科技有限责任公司 | Water-in-oil composition with acne removal, skin rejuvenation and slow release effects and application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112006934A (en) * | 2020-09-04 | 2020-12-01 | 江苏美爱斯化妆品股份有限公司 | Cosmetic compound with mild acne removing effect and application thereof |
| CN114224810A (en) * | 2021-12-31 | 2022-03-25 | 湖南亚大丰晖新材料有限公司 | Preparation method and application of novel water-soluble acne-removing composite material |
| CN115844796A (en) * | 2022-12-27 | 2023-03-28 | 陕西慧康生物科技有限责任公司 | Water-in-oil composition with acne removal, skin rejuvenation and slow release effects and application |
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| CB02 | Change of applicant information |
Address after: 511434 No. 13, Liu Wei street, Hualong Town, Panyu District, Guangzhou, Guangdong Applicant after: Hua An Tang biotech Group Co., Ltd. Address before: 511434 No. 13, Liu Wei street, Hualong Town, Panyu District, Guangzhou, Guangdong Applicant before: City flower An Tang bio tech ltd, Guangzhou |
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