CN107670093A - A kind of anti-sticky type antibacterial medical bandage - Google Patents
A kind of anti-sticky type antibacterial medical bandage Download PDFInfo
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- CN107670093A CN107670093A CN201711150753.0A CN201711150753A CN107670093A CN 107670093 A CN107670093 A CN 107670093A CN 201711150753 A CN201711150753 A CN 201711150753A CN 107670093 A CN107670093 A CN 107670093A
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- bandage
- medical bandage
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 27
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 23
- 229920000742 Cotton Polymers 0.000 claims abstract description 19
- 238000005238 degreasing Methods 0.000 claims abstract description 17
- 238000006243 chemical reaction Methods 0.000 claims description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 5
- 241000205585 Aquilegia canadensis Species 0.000 claims description 5
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 5
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 5
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 5
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 5
- 241000576429 Forsythia suspensa Species 0.000 claims description 5
- 235000011201 Ginkgo Nutrition 0.000 claims description 5
- 244000194101 Ginkgo biloba Species 0.000 claims description 5
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 5
- 235000013717 Houttuynia Nutrition 0.000 claims description 5
- 240000000691 Houttuynia cordata Species 0.000 claims description 5
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical class CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 5
- OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical class CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 claims description 5
- 241000123069 Ocyurus chrysurus Species 0.000 claims description 5
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 5
- 244000179560 Prunella vulgaris Species 0.000 claims description 5
- 240000003152 Rhus chinensis Species 0.000 claims description 5
- 235000014220 Rhus chinensis Nutrition 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 239000011425 bamboo Substances 0.000 claims description 5
- 239000010231 banlangen Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 5
- 230000001376 precipitating effect Effects 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000002390 rotary evaporation Methods 0.000 claims description 5
- 235000008113 selfheal Nutrition 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 3
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 150000002240 furans Chemical class 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 244000082204 Phyllostachys viridis Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000002068 microbial inoculum Substances 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 abstract description 2
- 108010054147 Hemoglobins Proteins 0.000 abstract description 2
- 206010067268 Post procedural infection Diseases 0.000 abstract description 2
- 208000007536 Thrombosis Diseases 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 2
- 230000000903 blocking effect Effects 0.000 abstract description 2
- 238000012827 research and development Methods 0.000 abstract description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 241001330002 Bambuseae Species 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 244000294611 Punica granatum Species 0.000 description 3
- 235000014360 Punica granatum Nutrition 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000004575 stone Substances 0.000 description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 150000001896 cresols Chemical class 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 230000002022 anti-cellular effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to the research and development technology field of medical bandage, disclose a kind of anti-sticky type antibacterial medical bandage, antistick characteristic material and antiseptic are added on degreasing cotton gauze, absorption property of the antistick characteristic material being prepared on bandage is very strong, be not in come off, the antiseptic used is prepared selected from natural component, antibacterial bacteriostatic effect is good, it is not in more postoperative infection, because the bandage has been assigned resistance to bond, and can in use is enough easy to remove bandage from wound face, the adhesion of hemoglobin and blood clot can effectively be suppressed, anti- sticky type antibacterial medical bandage prepared by the present invention is in resist blocking and that, biocompatibility, antibacterial, mechanical strength and simplicity are easy-to-use etc. has its unique advantage, had broad application prospects in bio-medical field.
Description
Technical field
The invention belongs to the research and development technology field of medical bandage, and in particular to a kind of anti-sticky type antibacterial medical bandage.
Background technology
Medical bandage is the gauze belt in place or affected part of binding up a wound, and is common medical supplies, there is many variety classeses.Letter
Single one kind is single canopy band, is made up of gauze or cotton, suitable for four limbs, afterbody, head and thorax abdomen.Multiple bandage is by portion
Position and shape and manufactured variously-shaped bandage, material are double-layer cloth, the cotton of different-thickness can be pressed from both sides therebetween, there is cloth on periphery
Bar, so as to the fixation that knots, such as eye bandage, back of the body waist bandage, shirtfront bandage, abdomen bandage are He Withers first bandages.Special bandage is more four
Limb and joint part are used as fixed.
Medical bandage primarily solves the problems, such as it is high infection risk, and bandage is that the moist environment that wound provides equally also is adapted for
The growth and breeding of germ, generally, people can allow bandage silver particles to be used to kill bacterium, still, the usage amount of silver particles
Cross conference limitation or lessen the curative effect and have a negative impact to mammalian cell, therefore,
It can select to add antiseptic on medical bandage material, release in a controlled manner reaches the purpose of sterilization, together
When cell compatibility it is more preferable.
Medical bandage another need to solve the problems, such as to be influence of the bandage adhesion for wound healing, it is necessary to research and develop one
The kind anti-sticky material of hydrophobic type is coated in medical bandage surface, plays anti-cellular adhesion effect, promotes the healing of wound.
The content of the invention
The purpose of the present invention is to be directed to the problem of existing, there is provided a kind of anti-sticky type antibacterial medical bandage, can be obtained
Double effects with anti-adhesive and bacteria growing inhibiting.
The present invention is achieved by the following technical solutions：
A kind of anti-sticky type antibacterial medical bandage, adds antistick characteristic material and antiseptic, the antiseptic on degreasing cotton gauze
It is made up in parts by weight of following component：Leaf of bamboo 12.5-13.5 parts, ginkgo leaf 12.0-13.0 parts, honeysuckle 11.5-12.0
Part, capsule of weeping forsythia 10.5-11.0 parts, granatum 8.5-9.5 parts, cordate houttuynia 8.0-9.0 parts, radix glycyrrhizae 7.5-8.5 parts, Radix Isatidis 7.0-
8.0 parts, Chinese gall 6.5-7.5 parts, selfheal 6.0-7.0 parts, Liaolan 5.5-6.0 parts, folium artemisiae argyi 4.5-5.5 parts, madder 3.5-4.5
Part；The preparation method of the antistick characteristic material comprises the following steps：
（1）0.5-0.6mol 2- methylaminoethanols are added in round-bottomed flask, under 0-3 DEG C of condition of ice bath, by dividing
0.5-0.7mol ethyl acrylate is added dropwise in liquid funnel, after stirring reaction 7-9 hours, obtains product and is filtered, washed, done
It is dry, dried product is added in round-bottomed flask, the ethylenediamine of 15-20 milliliters is added, 0.3- is added dropwise after heating for dissolving
The 2 of 0.4mol, 6 one BHTs, heating response 30-40 minutes；
（2）To step（1）Reaction system in 0.8-1mol hydroxyethyl methacrylates, while add the tetrahydrochysene of 50-60 milliliters
Furans, after being sufficiently stirred, it is passed through nitrogen and removes the oxygen in system, reaction system is used to 60-70 DEG C of oil bath heating, instead
3-5 hours are answered, nitrogen is constantly passed through in reaction；
（3）After reaction terminates, room temperature is cooled to, product carries out rotary evaporation at 30-35 DEG C, removes solvent, the production that will be obtained
Thing further cleans cleaning, using centrifuge under 3500-4000 revs/min of rotating speed rotating centrifugal, obtain precipitating use
Ionized water cleaning 3-5 is dried after in 50-60 DEG C of drying box, can be sealed after drying to constant weight.
Further described as to such scheme, addition quality percentage of the antistick characteristic material on degreasing cotton gauze
Than for 15.0-16.0%.
Further described as to such scheme, addition mass percent of the antiseptic on degreasing cotton gauze is
3.5-4.5%。
Further described as to such scheme, the step（1）Middle heating response temperature is 80-90 DEG C.
Further described as to such scheme, the antistick characteristic material and antiseptic are added to system after ultrasound mixes
In the mould of standby medical bandage.
The present invention has advantages below compared with prior art：In order to solve existing medical bandage in adhesiveness and antibiotic property
To caused by human body the problem of ill effect, the invention provides a kind of anti-sticky type antibacterial medical bandage, in degreasing cotton gauze
Upper addition antistick characteristic material and antiseptic, absorption property of the antistick characteristic material being prepared on bandage is very strong, will not go out
Now come off, the antiseptic used is prepared selected from natural component, and antibacterial bacteriostatic effect is good, is not in more postoperative infection, because this is taut
Band has been assigned resistance to bond, and and can in use is enough easy to remove bandage from wound face, can effectively suppress hemoglobin
With the adhesion of blood clot, anti-sticky type antibacterial medical bandage prepared by the present invention is in resist blocking and that, biocompatibility, antibacterial, machinery
Intensity and simplicity are easy-to-use etc. has its unique advantage, is had broad application prospects in bio-medical field.
Embodiment
With reference to specific embodiment, the invention will be further described.
Embodiment 1
A kind of anti-sticky type antibacterial medical bandage, adds antistick characteristic material and antiseptic, the antiseptic on degreasing cotton gauze
It is made up in parts by weight of following component：12.5 parts of the leaf of bamboo, 12.0 parts of ginkgo leaf, 11.5 parts of honeysuckle, 10.5 parts of the capsule of weeping forsythia, stone
8.5 parts of pomegranate skin, 8.0 parts of cordate houttuynia, 7.5 parts of radix glycyrrhizae, 7.0 parts of Radix Isatidis, 6.5 parts of Chinese gall, 6.0 parts of selfheal, Liaolan 5.5
Part, 4.5 parts of folium artemisiae argyi, 3.5 parts of madder；The preparation method of the antistick characteristic material comprises the following steps：
（1）0.5mol 2- methylaminoethanols are added in round-bottomed flask, under 0 DEG C of condition of ice bath, pass through separatory funnel
0.5mol ethyl acrylate is added dropwise, stirring reaction obtains product and filtered, washed, dried after 7 hours, will be dried
Product is added in round-bottomed flask, adds 15 milliliters of ethylenediamine, and 0.3mol 2,6 one di-t-butyls pair are added dropwise after heating for dissolving
Cresols, heating response 30 minutes；
（2）To step（1）Reaction system in 0.8mol hydroxyethyl methacrylates, while add 50 milliliters of tetrahydrofuran,
After being sufficiently stirred, it is passed through nitrogen and removes the oxygen in system, reaction system is used to 60 DEG C of oil bath heating, react 3 hours,
Nitrogen is constantly passed through in reaction；
（3）After reaction terminates, room temperature is cooled to, product carries out rotary evaporation at 30 DEG C, removes solvent, obtained product is entered
One step removal of impurities cleaning, using centrifuge under 3500 revs/min of rotating speed rotating centrifugal, obtain precipitating and cleaned using deionized water
After 3 times, it is dried in 50 DEG C of drying box, can be sealed after drying to constant weight.
Further described as to such scheme, addition quality percentage of the antistick characteristic material on degreasing cotton gauze
Than for 15.0%.
Further described as to such scheme, addition mass percent of the antiseptic on degreasing cotton gauze is
3.5%。
Further described as to such scheme, the step（1）Middle heating response temperature is 80 DEG C.
Further described as to such scheme, the antistick characteristic material and antiseptic are added to system after ultrasound mixes
In the mould of standby medical bandage.
Embodiment 2
A kind of anti-sticky type antibacterial medical bandage, adds antistick characteristic material and antiseptic, the antiseptic on degreasing cotton gauze
It is made up in parts by weight of following component：13.0 parts of the leaf of bamboo, 12.5 parts of ginkgo leaf, 11.8 parts of honeysuckle, 10.8 parts of the capsule of weeping forsythia, stone
9.0 parts of pomegranate skin, 8.5 parts of cordate houttuynia, 8.0 parts of radix glycyrrhizae, 7.5 parts of Radix Isatidis, 7.0 parts of Chinese gall, 6.5 parts of selfheal, Liaolan 5.8
Part, 5.0 parts of folium artemisiae argyi, 4.0 parts of madder；The preparation method of the antistick characteristic material comprises the following steps：
（1）0.55mol 2- methylaminoethanols are added in round-bottomed flask, under 2 DEG C of condition of ice bath, pass through separatory funnel
0.6mol ethyl acrylate is added dropwise, stirring reaction obtains product and filtered, washed, dried after 8 hours, will be dried
Product is added in round-bottomed flask, adds 18 milliliters of ethylenediamine, and 0.35mol 2,6 one di-t-butyls are added dropwise after heating for dissolving
Paracresol, heating response 35 minutes；
（2）To step（1）Reaction system in 0.9mol hydroxyethyl methacrylates, while add 55 milliliters of tetrahydrofuran,
After being sufficiently stirred, it is passed through nitrogen and removes the oxygen in system, reaction system is used to 65 DEG C of oil bath heating, react 4 hours,
Nitrogen is constantly passed through in reaction；
（3）After reaction terminates, room temperature is cooled to, product carries out rotary evaporation at 33 DEG C, removes solvent, obtained product is entered
One step removal of impurities cleaning, using centrifuge under 3800 revs/min of rotating speed rotating centrifugal, obtain precipitating and cleaned using deionized water
After 4 times, it is dried in 55 DEG C of drying box, can be sealed after drying to constant weight.
Further described as to such scheme, addition quality percentage of the antistick characteristic material on degreasing cotton gauze
Than for 15.5%.
Further described as to such scheme, addition mass percent of the antiseptic on degreasing cotton gauze is
4.0%。
Further described as to such scheme, the step（1）Middle heating response temperature is 85 DEG C.
Further described as to such scheme, the antistick characteristic material and antiseptic are added to system after ultrasound mixes
In the mould of standby medical bandage.
Embodiment 3
A kind of anti-sticky type antibacterial medical bandage, adds antistick characteristic material and antiseptic, the antiseptic on degreasing cotton gauze
It is made up in parts by weight of following component：13.5 parts of the leaf of bamboo, 13.0 parts of ginkgo leaf, 12.0 parts of honeysuckle, 11.0 parts of the capsule of weeping forsythia, stone
9.5 parts of pomegranate skin, 9.0 parts of cordate houttuynia, 8.5 parts of radix glycyrrhizae, 8.0 parts of Radix Isatidis, 7.5 parts of Chinese gall, 7.0 parts of selfheal, Liaolan 6.0
Part, 5.5 parts of folium artemisiae argyi, 4.5 parts of madder；The preparation method of the antistick characteristic material comprises the following steps：
（1）0.6mol 2- methylaminoethanols are added in round-bottomed flask, under 3 DEG C of condition of ice bath, pass through separatory funnel
0.7mol ethyl acrylate is added dropwise, stirring reaction obtains product and filtered, washed, dried after 9 hours, will be dried
Product is added in round-bottomed flask, adds 20 milliliters of ethylenediamine, and 0.4mol 2,6 one di-t-butyls pair are added dropwise after heating for dissolving
Cresols, heating response 40 minutes；
（2）To step（1）Reaction system in 1mol hydroxyethyl methacrylates, while add 60 milliliters of tetrahydrofuran, fill
After point stirring, it is passed through nitrogen and removes the oxygen in system, reaction system is used into 70 DEG C of oil bath heating, react 5 hours, instead
Nitrogen is constantly passed through in answering；
（3）After reaction terminates, room temperature is cooled to, product carries out rotary evaporation at 35 DEG C, removes solvent, obtained product is entered
One step removal of impurities cleaning, using centrifuge under 4000 revs/min of rotating speed rotating centrifugal, obtain precipitating and cleaned using deionized water
After 5 times, it is dried in 60 DEG C of drying box, can be sealed after drying to constant weight.
Further described as to such scheme, addition quality percentage of the antistick characteristic material on degreasing cotton gauze
Than for 16.0%.
Further described as to such scheme, addition mass percent of the antiseptic on degreasing cotton gauze is
4.5%。
Further described as to such scheme, the step（1）Middle heating response temperature is 90 DEG C.
Further described as to such scheme, the antistick characteristic material and antiseptic are added to system after ultrasound mixes
In the mould of standby medical bandage.
Claims (5)
1. a kind of anti-sticky type antibacterial medical bandage, it is characterised in that antistick characteristic material is added on degreasing cotton gauze and is resisted
Microbial inoculum, the antiseptic are made up of following component in parts by weight：Leaf of bamboo 12.5-13.5 parts, ginkgo leaf 12.0-13.0 parts, gold
Honeysuckle flower 11.5-12.0 parts, capsule of weeping forsythia 10.5-11.0 parts, granatum 8.5-9.5 parts, cordate houttuynia 8.0-9.0 parts, radix glycyrrhizae 7.5-8.5
Part, Radix Isatidis 7.0-8.0 parts, Chinese gall 6.5-7.5 parts, selfheal 6.0-7.0 parts, Liaolan 5.5-6.0 parts, folium artemisiae argyi 4.5-5.5
Part, madder 3.5-4.5 parts；The preparation method of the antistick characteristic material comprises the following steps：
（1）0.5-0.6mol 2- methylaminoethanols are added in round-bottomed flask, under 0-3 DEG C of condition of ice bath, by dividing
0.5-0.7mol ethyl acrylate is added dropwise in liquid funnel, after stirring reaction 7-9 hours, obtains product and is filtered, washed, done
It is dry, dried product is added in round-bottomed flask, the ethylenediamine of 15-20 milliliters is added, 0.3- is added dropwise after heating for dissolving
The 2 of 0.4mol, 6 one BHTs, heating response 30-40 minutes；
（2）To step（1）Reaction system in 0.8-1mol hydroxyethyl methacrylates, while add the tetrahydrochysene of 50-60 milliliters
Furans, after being sufficiently stirred, it is passed through nitrogen and removes the oxygen in system, reaction system is used to 60-70 DEG C of oil bath heating, instead
3-5 hours are answered, nitrogen is constantly passed through in reaction；
（3）After reaction terminates, room temperature is cooled to, product carries out rotary evaporation at 30-35 DEG C, removes solvent, the production that will be obtained
Thing further cleans cleaning, using centrifuge under 3500-4000 revs/min of rotating speed rotating centrifugal, obtain precipitating use
Ionized water cleaning 3-5 is dried after in 50-60 DEG C of drying box, can be sealed after drying to constant weight.
2. a kind of anti-sticky type antibacterial medical bandage as claimed in claim 1, it is characterised in that the antistick characteristic material is in degreasing
Addition mass percent on cotton gauze is 15.0-16.0%.
3. a kind of anti-sticky type antibacterial medical bandage as claimed in claim 1, it is characterised in that the antiseptic is in degreasing cotton yarn
Addition mass percent on cloth is 3.5-4.5%.
A kind of 4. anti-sticky type antibacterial medical bandage as claimed in claim 1, it is characterised in that the step（1）Middle heating is anti-
It is 80-90 DEG C to answer temperature.
5. a kind of anti-sticky type antibacterial medical bandage as claimed in claim 1, it is characterised in that the antistick characteristic material and antibacterial
Agent is added in the mould for preparing medical bandage after ultrasound mixes.
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| CN201711150753.0A CN107670093A (en) | 2017-11-18 | 2017-11-18 | A kind of anti-sticky type antibacterial medical bandage |
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| CN201711150753.0A CN107670093A (en) | 2017-11-18 | 2017-11-18 | A kind of anti-sticky type antibacterial medical bandage |
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| CN108939126A (en) * | 2018-07-05 | 2018-12-07 | 安徽玉然经编科技有限公司 | A kind of medical bandage of aqueous gel antibiotic layer |
| CN108939142A (en) * | 2018-07-05 | 2018-12-07 | 安徽玉然经编科技有限公司 | A kind of dressing of the microballoon containing composite antibacterial |
| CN109267358A (en) * | 2018-09-20 | 2019-01-25 | 合肥巧织纺织科技有限公司 | A kind of durable antibiotic absorbent cotton |
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