CN1076626A - Medicine taken after being mixed with boiling water for liver trouble - Google Patents
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Abstract
The invention discloses a kind of Chinese patent medicine that is used for the treatment of hepatitis disease---Medicine taken after being mixed with boiling water for liver trouble, this electuary contain ten pleasant impression Chinese herbal medicine such as Herba Artemisiae Scopariae, the Radix Astragali, Radix Bupleuri, Radix Et Rhizoma Rhei, Polyporus, Radix Codonopsis, Folium Isatidis, Radix Angelicae Sinensis, Herba Sedi through distillation, decoct, concentrate, drying forms.Through this electuary of zoology test to dhbv dna DNA suppression ratio up to more than 61%, clinical observation on the therapeutic effect confirms that total effective rate reaches more than 89%, the HBSAg negative conversion rate reaches 57.5%, the HBeAg negative conversion rate reaches 49.3%, really for treating the desirable Chinese patent medicine of hepatitis B, especially chronic hepatitis.
Description
The present invention relates to a kind of medicine for the treatment of hepatitis disease, particularly a kind of Chinese patent medicine for the treatment of hepatitis B.
China is the sick district occurred frequently of hepatitis, especially the heavy epidemic-stricken area of hepatitis B (abbreviation hepatitis B), existing hepatitis B virus carriers 1.2 hundred million people (wherein 1/4 people can develop into the chronic hepatitis disease eventually), about 1,200 ten thousand examples of chronic hepatitis patient are arranged, annual because of the dead number of hepatopathy reaches 300,000, and 40% mother who carries hepatitis B virus can give the baby with viral communication.Medical circle brings the infectious disease of very big harm to carry out a large amount of research work for treatment is this to human health both at home and abroad, worked out multiple therapeutic scheme, high amount of drug and prescription have been screened, but up to the present, the selected medicine side effect of western medical treatment hepatitis is big, cost an arm and a leg, need change more than 20,000 yuan of expense a course of treatment that has, and curative effect is still imprecise, the research of Chinese traditional treatment hepatitis disease has obtained certain effect, Zhejiang Journal of Traditional Chinese Medicine the 2nd phase of nineteen eighty-three has been reported with the sick total effective rate of astragalus needle treatment hepatitis B and has reached 66.6%, the HBsAg negative conversion rate reaches 33.3%, 1985 the 2nd phases of Sichuan Journal of Traditional Chinese Medicine report reaches 82% with the sick total effective rate of liver heat removing soup treatment hepatitis, report in the FUGANKANG agent monograph that pharmaceutical factory of Liaoning Research Institute of Traditional Chinese Medicine prints nineteen ninety, China has implemented since the provisions for new drugs approval, first the national pure Chinese medicinal preparation-FUGANKANG agent that is used for the treatment of hepatitis, select Radix Salviae Miltiorrhizae for use, Radix Bupleuri, the Radix Astragali, Rhizoma Cyperi (processed with vinegar), Radix Angelicae Sinensis, 13 flavor Chinese medicines such as Radix Paeoniae Rubra are formulated, to the sick clinical total effective rate of hepatitis B is 74.9%, clinical cure rate 28.75%, HBV-DNA changes natural rate of interest 44.74%, and HBeAg changes natural rate of interest 49.23%.Although above-mentioned Chinese patent medicine is higher to the sick clinical total effective rate of hepatitis, but mostly its effect is to take a turn for the better and liver function is improved and determined according to clinical symptoms, sign, and observing time is shorter, improvement to this specific parameters of negative conversion rate of hepatitis B virus antigen HBsAg is undesirable, especially from eliminating the cause of disease in essence, still lower to the inhibitory action of the HBV-DNA of infectosome machine.
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of HBsAg negative conversion rate higher, improve pathology, adjust body's immunity, be beneficial to the removing cause of disease, the high Medicine taken after being mixed with boiling water for liver trouble of body HBV-DNA suppression ratio of catching an illness.
Purpose of the present invention realizes by following technical proposals:
Get the raw materials ready by following component and weight portion: Radix Astragali 10-30 weight portion, Radix Ginseng 0-15 weight portion, Radix Codonopsis 0-15 weight portion, Radix Bupleuri 10-15 weight portion, Polyporus 0-20 weight portion, Poria 0-20 weight portion, Herba Artemisiae Scopariae 10-20 weight portion, Fructus Gardeniae (parched to brown) 0-20 weight portion, Radix Isatidis 0-20 weight portion, Folium Isatidis 0-20 weight portion, Herba Lysimachiae 0-20 weight portion, Radix Et Rhizoma Rhei 5-15 weight portion, Radix Angelicae Sinensis 0-15 weight portion, Radix Salviae Miltiorrhizae 0-15 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Hedyotidis Diffusae 0-20 weight portion, Herba Sedi 0-20 weight portion, Radix Cynanchi Paniculati 0-20 weight portion, cyrtomium fortunei 0-20 weight portion, other has above-mentioned each component total amount 7-8 clean water doubly.
Radix Ginseng, Radix Codonopsis must not be zero simultaneously in the above-mentioned component, and its total amount must not be less than 5 weight portions when using one or both mixture, must not be greater than 15 weight portions.Fructus Gardeniae (parched to brown), Radix Isatidis, Folium Isatidis, four kinds of components of Herba Lysimachiae must not be zero simultaneously, and its total amount is no less than 10 weight portions when selecting one or both and above mixture for use, is not more than 25 weight portions.Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae must not be zero simultaneously, when selecting for use a kind of or during two kinds of mixture, its total amount is no less than 5 weight portions, is not more than 15 weight portions.Herba Hedyotidis Diffusae, Herba Sedi, Radix Cynanchi Paniculati, cyrtomium fortunei must not be zero simultaneously, and when selecting one or more mixture for use, its total amount is no less than 10 weight portions, is not more than 20 weight portions.Polyporus, Poria must not be zero simultaneously, and select for use a kind of or two kinds of mixture, and its total amount is no less than 10 weight portions, is not more than 20 weight portions.
Aforesaid two or more mixture is meant with any mixed, but must not is zero simultaneously.
Concrete processing technology is: after getting the raw materials ready, the Herba Artemisiae Scopariae of volatile oil composition will be arranged at first, Radix Angelicae Sinensis merges, and adds the water of 1-1.5 times of weight of Herba Artemisiae Scopariae, Radix Angelicae Sinensis gross weight, soaks into, and feeds steam and makes it to reach 0.2Kg/cm
2, distill out volatile oil, it is standby to collect volatile oil, Herba Artemisiae Scopariae after the distillation, Radix Angelicae Sinensis slag mix with other various components, the decocting that adds 4 times of weight of said mixture gross weight boils filtration in 1-2 hour, taking liquid is standby, and the decocting that medicinal residues add 3 times of weight again boiled 1-2 hour, filtration, waste.Collect medicinal liquid, secondary medicinal liquid and Radix Angelicae Sinensis Herba Artemisiae Scopariae volatile oil are merged, spray drying, packing is Medicine taken after being mixed with boiling water for liver trouble.
Because Medicine taken after being mixed with boiling water for liver trouble is different but play synergistic Chinese medicine mutually and form by three groups of functions, the Radix Astragali, Radix Codonopsis, Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Glycyrrhizae has qi and blood tonifying, easing the affected liver emergency function, play centralizing function, Herba Artemisiae Scopariae, Fructus Gardeniae (parched to brown), Folium Isatidis, Radix Isatidis, Herba Lysimachiae, Poria, Herba Sedi, Radix Cynanchi Paniculati, cyrtomium fortunei, Radix Et Rhizoma Rhei, Polyporus, Herba Hedyotidis Diffusae has heat clearing away, the detoxification and promoting urination resolving functions, play eliminating evil effect, Radix Bupleuri, Radix Glycyrrhizae has the resolving depression eliminating stagnation, the sexual function of multiple liver bar, three groups of organically combinations of medicine have embodied the strengthening vital QI to eliminate pathogenic factors of Chinese traditional treatment hepatitis disease, the Therapeutic Method of clearing away heat-damp and promoting diuresis detoxifcation and dispersing the stagnated live-QI to relieve the stagnation of QI.
Thinking from modern medicine treatment hepatitis B, the effectiveness of Medicine taken after being mixed with boiling water for liver trouble also is described, the Radix Astragali in this electuary, Radix Codonopsis or Radix Ginseng, Radix Angelicae Sinensis or Radix Salviae Miltiorrhizae and Radix Glycyrrhizae can be regulated the cellular immunization and the humoral immunization of human body, and the Radix Astragali, Radix Glycyrrhizae can also inducement interferons, reach the effect that suppresses virus replication.Herba Artemisiae Scopariae, Fructus Gardeniae (parched to brown), Radix Isatidis, Folium Isatidis, Herba Lysimachiae, Radix Et Rhizoma Rhei, Polyporus, Poria, Herba Hedyotidis Diffusae, Herba Sedi, Radix Cynanchi Paniculati, the existing immunity excitement of cyrtomium fortunei, immune suppression function is arranged again, suppress HBsAg, hepatic cholagogic, strengthen the function of detoxification of liver, metabolite is leaked, Radix Bupleuri, Radix Glycyrrhizae can stop the hepatic fibrosis hypertrophy, and be very favourable to the treatment of chronic hepatitis.
Zoopery has confirmed that Medicine taken after being mixed with boiling water for liver trouble is very effective to curing the hepatitis disease, below brief introduction part zoopery result, zoopery is undertaken by the Chuanbei Medical College and the Chinese Academy of Medical Sciences respectively.
1, to effect of immunologic function: establish normal group (A), immune matched group (B) levamisole group (C), Medicine taken after being mixed with boiling water for liver trouble group (E), except that normal group, each group all uses 5% sheep red blood cell (SRBC) (SRBC) only to make antigen lumbar injection immunity 0.2ml/, gavage normal saline, 1% levamisole liquid, 40% Medicine taken after being mixed with boiling water for liver trouble according to grouping every day after the inoculation, 6-8 day, all continuous three days intramuscular injection phytohaemagglutinin 0.05ml/ of each group only.
Broken end was got blood push jack and separation of serum on 1, detected lymhocyte transformation rate and serum antibody level, result such as table 1, table 2:
Table 1 Medicine taken after being mixed with boiling water for liver trouble is to the influence of lymhocyte transformation rate
Group No. of LT(%)
mice ( X±SD) P
A 15 4.04±1.04
B 15 7.58±0.94 A:B<0.01 A:C<0.01
C 15 2.56±0.50 B:C<0.01 A:E>0.05
E 15 4.56±0.47 B:E<0.01 C:E<0.01
Table 2 Medicine taken after being mixed with boiling water for liver trouble is to the influence of SRBC antibody titer
Group No. of antibody titer P
mice ( X±SD)
B 15 1:1156.8±288.9 B:E>0.05
C 15 1:6744±552.1 B:C<0.05
E 15 1:1280±196 C:E<0.05
Table 1 result shows that Medicine taken after being mixed with boiling water for liver trouble strengthens reflection to experimental cell and has the obvious suppression effect, and does not suppress the organism normal cell immunologic function.Table 2 is the result show, Medicine taken after being mixed with boiling water for liver trouble has the immunoregulation effect of similar levamisole, they can make body because of antigenic stimulus produces a certain amount of antibody, therefore antibody horizontal rises so high in the blood but can not make.
2, Medicine taken after being mixed with boiling water for liver trouble is tested the enzyme that falls of rat carbon tetrachloride hepatic injury:
Select rat 135 ± 35g50 only to divide five groups at random, 1.2 groups of administrations 0.5 respectively of Medicine taken after being mixed with boiling water for liver trouble, 1.0g/100g, Fructus Schisandrae Chinensis matched group 1.0/100g, blank group and carbon tetrachloride damage group are given the equivalent normal saline respectively, gavage every day once, except that the blank group, all the other all gavage carbon tetrachloride Oleum Sesami solution 80mg/100g after 10 days, get blood after 24 hours and measure serum SGPT, SGOT activity, result such as table 3 by the Nai Shi method.
Table 3 Medicine taken after being mixed with boiling water for liver trouble is to ccl
4Due to rat serum SGPT, SGOT the influence
Group dosage Mus is counted SGPT SGOT
(g/100gd
-1* 10d) (only) (unit) (unit)
Blank group 10 39 ± 12 124 ± 23
CCl4 matched group 10 74 ± 42 178 ± 32
Fructus Schisandrae Chinensis group 1.0 10 42 ± 18* 158 ± 29
1 group of 0.5 10 44 ± 16*, 143 ± 20* of Medicine taken after being mixed with boiling water for liver trouble
2 groups of 1.0 10 41 ± 20*, 130 ± 25* of Medicine taken after being mixed with boiling water for liver trouble
* with Ccl
4Matched group is P＜0.05 relatively
Table 3 is the result show, Medicine taken after being mixed with boiling water for liver trouble is heavy dose of all obviously to reduce rat SGPT and SGOP activity (P＜0.05) with small dose group, does not relatively have significant difference with positive control Fructus Schisandrae Chinensis group, illustrates that Medicine taken after being mixed with boiling water for liver trouble can obviously resist Ccl
4Caused hepatocyte injury, the rising of SGPT and SGOT in the inhibition serum.
3, Medicine taken after being mixed with boiling water for liver trouble is to the active influence of rat plasma lactic dehydrogenase: select the 100-150g healthy white rat, be divided into 5 groups at random, 1,2,3 groups of administrations 0.5,0.75 respectively of Medicine taken after being mixed with boiling water for liver trouble, 1.0g/100g, Radix Ginseng matched group 5mg/100g, negative control group is given the equivalent normal saline, gavage every day once, after 21 days, rat subcutaneous injection of carbon tetrachloride 0.1ml/100g, get blood after 24 hours, measure plasma lactic dehydrogenase (LDH) activity, result such as table 4 by the stupid hydrazine method of 2,4 dinitros.
Table 4 Medicine taken after being mixed with boiling water for liver trouble is to ccl
4Due to the influence that raises of rat blood plasma LDH
Group dosage Mus is counted LDH (unit)
G/100gd-1 * 21d (only) X ± SD
Ccl4 matched group 12 649 ± 249
Radix Ginseng group 11 557 ± 202
1 group 0.5 12 531 ± 162 of Medicine taken after being mixed with boiling water for liver trouble
2 group 0.75 11 409 ± 98* of Medicine taken after being mixed with boiling water for liver trouble
3 group of 1.0 12 386 ± 149 △ of Medicine taken after being mixed with boiling water for liver trouble
* P＜0.05 △ P＜0.01 of comparing with matched group
Table 4 is the result show, Medicine taken after being mixed with boiling water for liver trouble can obviously resist ccl
4The hepatocyte injury that causes suppresses LDH rising in the serum, and has a certain amount of effect relationship.
4, Medicine taken after being mixed with boiling water for liver trouble is to the influence of rat blood hemoglobin (Hb) content
Select 45 of healthy white rats, random packet, 1,2 groups of Medicine taken after being mixed with boiling water for liver trouble respectively by 0.5,1.0g/100g, the Radix Ginseng group press 5mg/100g, matched group is given the equivalent normal saline, gavages every day once, after continuous 20 days, gets blood by photoelectric colorimetry detection blood plasma Hb content.The result is as shown in table 5.
Table 5 Medicine taken after being mixed with boiling water for liver trouble is to the influence of rat blood plasma Hb content
Group dosage Mus is counted Hb (g/L)
g/100gd
-1×20d X±SD
Only
Matched group 12 103 ± 7.7
Radix Ginseng group 0.05 11 113 ± 12*
1 group of 0.5 11 119 ± 11 △ of Medicine taken after being mixed with boiling water for liver trouble
2 groups of 1.0 11 114 ± 14* of Medicine taken after being mixed with boiling water for liver trouble
Compare * P＜0.05 △ P＜0.01 with matched group
Table 5 is the result show, low dose of Medicine taken after being mixed with boiling water for liver trouble group obviously increases rat blood plasma Hb content (P＜0.01); It is similar to Radix Ginseng that heavy dose of Medicine taken after being mixed with boiling water for liver trouble group increases the effect of rat blood plasma Hb content, and the effect that Medicine taken after being mixed with boiling water for liver trouble has increases rat blood plasma Hb content is described.
5, Medicine taken after being mixed with boiling water for liver trouble is to the antagonism of rat Ovum Gallus domesticus album swollen joint:
Select the healthy white rat random packet, 1,2 groups of administrations 0.5 respectively of Medicine taken after being mixed with boiling water for liver trouble, 1.0g/100g, Radix Ginseng group 5.0mg/100g, matched group equivalent normal saline, gavage every day once, after continuous 14 days, volumetric method is measured respectively and is respectively organized rat Ovum Gallus domesticus album to the left back sufficient volume in scorching front and back, according to the statistical disposition of swelling percentage rate, the results are shown in Table 6.
Table 6 Medicine taken after being mixed with boiling water for liver trouble is to the antagonism of rat Ovum Gallus domesticus album swollen joint
Group dosage Mus is counted ankle swelling percentage rate (X ± SD)
G/100gd-1 (only) 0.5h 1h 2h 3h
Matched group 12 56 ± 16 66 ± 23 51 ± 18 39 ± 19
Radix Ginseng group 0.005 11 50 ± 12 43 ± 22 33 ± 20 31 ± 17
Medicine taken after being mixed with boiling water for liver trouble 1 group 0.5 11 39 ± 9 35 ± 14 27 ± 16 23 ± 19
Medicine taken after being mixed with boiling water for liver trouble 2 group 1.0 11 48 ± 14 39 ± 20 27 ± 18 27 ± 18
Compare * P＜0.05 △ P＜0.01 with matched group
Table 6 is the result show, to scorching half an hour, the Medicine taken after being mixed with boiling water for liver trouble small dose group, the arthroncus degree obviously was lighter than matched group (P＜0.05) until 3 hours, this dosage group still shows inhibitory action (P＜0.05) to the rat albumen arthritis, the heavy dose of group antagonism of Medicine taken after being mixed with boiling water for liver trouble Ovum Gallus domesticus album swollen joint acts on appearance (P＜0.05) in 1 hour, continue 2 hours (P＜0.01) effect in 3 hours no significant difference (P＞0.05), the effect of Radix Ginseng group antagonism Ovum Gallus domesticus album swollen joint is similar to the Medicine taken after being mixed with boiling water for liver trouble heavy dose, (P＜0.05) occurred at 1 hour, continue to 2 hours (P＜0.05).Each group of Medicine taken after being mixed with boiling water for liver trouble all shows tangible antiinflammatory action (P＜0.05), points out this electuary can suppress the hepatic injury inflammatory process.
6, Medicine taken after being mixed with boiling water for liver trouble is tested the acute function of gallbladder promoting of normal rat:
Select 32 of healthy white rats, divide 4 groups at random, test fasting in preceding 12 hours and can't help water, the operation of anesthesia back forms the bile duct fistula, collects bile after 20 minutes, as the normal value of bile secretion before the administration.Give Medicine taken after being mixed with boiling water for liver trouble 1.0g/100g by duodenum respectively then, 0.5/100g makes test group, makes positive controls for chenodeoxycholic acid 1.0mg/100g, makes negative control group for the equivalent normal saline, continues to collect bile and metering.Relatively choleresis before and after the administration calculates bile secretion increase percentage rate, the results are shown in Table 7.
Table 7 Medicine taken after being mixed with boiling water for liver trouble is to the excretory influence of rat bile
Group dosage Mus is counted choleresis (ml) rate of increase
(g/100g) after the preceding administration of (only) administration (%)
Normal saline group 8 0.218 ± 0.057 0.275 ± 0.058 18.1
Chenodeoxycholic acid group 0.01 8 0.105 ± 0.065 0.261 ± 0.063 41.2
Medicine taken after being mixed with boiling water for liver trouble 1 group 1.0 8 0.213 ± 0.060 0.300 ± 0.079* 41.2
Medicine taken after being mixed with boiling water for liver trouble 2 group 0.5 8 0.204 ± 0.058 0.276 ± 0.054* 35.5
* with before the administration compare P＜0.05
Table 7 is the result show, 1 group, 2 groups of Medicine taken after being mixed with boiling water for liver trouble, the bile secretion rate of increase is respectively 41.2% before and after the administration of chenodeoxycholic acid group, 35.5% and 41.2%, choleresis relatively has significant difference (P＜0.05) before and after the administration, show that Medicine taken after being mixed with boiling water for liver trouble can obviously increase the choleresis of rat, has choleretic effect.
7, Medicine taken after being mixed with boiling water for liver trouble is to the influence test of sulfobromophthalein sodium (BSP) retention amount
Select healthy mice to divide 5 groups, Medicine taken after being mixed with boiling water for liver trouble to gavage Medicine taken after being mixed with boiling water for liver trouble 10g/kg, 5g/kg respectively every day for 1,2 groups at random, the Fructus Schisandrae Chinensis matched group gavages Fructus Schisandrae Chinensis liquid 10g/kg, matched group and ccl every day
4, the poisoning group gavages equivalent weight saline every day.In the 7th day except that the blank group, all the other respectively organize equal lumbar injection 0.1%ccl
4Oleum Sesami liquid 10ml/kg, after 16 hours, each is organized equal end of line vein and injects BsP200mg/kg, get blood after 20 minutes immediately, separation of serum is got serum 0.1ml, adds 0.01mol/LHcl15ml, with 721 spectrophotometers in the 520nm colorimetric, add 2mol/l then, NaoHl drips, once more colorimetric, represent the retention amount of BSP, result such as table 8 with the difference of twice reading in front and back
Table 8 Medicine taken after being mixed with boiling water for liver trouble is to the influence of BSP retention amount
Group dosage Mus is counted the retention amount
G/kg d-1 * 7 (only)
Blank group 8 453 ± 43
Cd4 matched group 10 8 615 ± 80
Fructus Schisandrae Chinensis matched group 10 8 470 ± 137*
1 group of 10 8 465 ± 99 △ of Medicine taken after being mixed with boiling water for liver trouble
2 groups of 58 480 ± 118* of Medicine taken after being mixed with boiling water for liver trouble
With comparison * P＜0.05 △ P＜0.01 before the administration
Table 8 result shows that 1,2 groups of Medicine taken after being mixed with boiling water for liver trouble are similar to Fructus Schisandrae Chinensis, all can obviously promote ccl
4Poisoning mice has pointed out Medicine taken after being mixed with boiling water for liver trouble to help to recover and improve the normal detoxifcation excretory function of liver to the drainage of BSP.
8, Medicine taken after being mixed with boiling water for liver trouble therapeutic effect to duck hepatitis B virus infection in the duck liver body is tested
Select old Beijing duck intravenous injection in age DHB DNA(DHBV-DNA), after 7 days before the administration (TO) get blood system from serum, frozen to be checked, grouping, every group of 4-6 only gives three kinds of dosage Medicine taken after being mixed with boiling water for liver trouble: 3g/kg, 2g/kg, 1g/kg is oral, every day 2 times, obeys 10 days, establish the virus control group with batch experiment, with the physiologic saline for substitute Medicine taken after being mixed with boiling water for liver trouble, administration the 5th day (T5), 3 days (P3) gets serum respectively after the 10th day (T10) and the drug withdrawal,-70 ℃ of preservations, make dot blot hybridization with criticizing, check DHBV-DNA level is calculated the variation of respectively organizing different time and the preceding serum DHBV-DNA level of its administration, the results are shown in Table 9, table 10.
Table 9
The oral Medicine taken after being mixed with boiling water for liver trouble of DHBV infected duck
To the clear DHBV-DNA of Sanguis Anas domestica
Influence (four batches results sum up)
Table 10 Medicine taken after being mixed with boiling water for liver trouble is to the effect of the clear DHBV-DNA of duck hepatitis B virus infection Sanguis Anas domestica
The clear DHBV-DNA of dosage group Sanguis Anas domestica suppresses %
(g/kg) T5 T10 P3
1 11.61 21.93 24.15
2 22.28 53.60 28.22
3 37.89 61.42 19.71
Table 9, table 10 result show that Medicine taken after being mixed with boiling water for liver trouble has duck hepatitis B virus infection and suppress effect preferably, dose-response relationship is arranged, taking medicine 10 days the time, 3g/kg reaches 61.42% to the clear DHBV-DNA suppression ratio of Sanguis Anas domestica, have not yet to see Chinese patent medicine so high inhibition effect is arranged, the 2g/kg suppression ratio reaches 53.6%, the 1g/kg suppression ratio reaches 21.93%, after the drug withdrawal, the clear viral DNA of part Sanguis Anas domestica has knock-on, and drug withdrawal suppressed % in three days and reduces to 19.71-28.22%, if the administration time lengthening, estimate can further improve suppression ratio, reduce rebound phenomenon.
In addition, Medicine taken after being mixed with boiling water for liver trouble has also carried out animal acute toxicity test and long term toxicity test.Binomial trials is the result show, it is safe that Medicine taken after being mixed with boiling water for liver trouble is used, and animal is not had obvious toxic and side effects.
Medicine taken after being mixed with boiling water for liver trouble, and is established non-hepatic disorder electuary treatment group and is contrasted 156 routine chronic hepatitis b clinical observations through Hospital Attached to Chuanbai Medical College, the People's Hospital, Suining City and 51 hospitals of PLA, and three months treatment times, efficacy result sees Table 11
The clinical observation result of table 11 Medicine taken after being mixed with boiling water for liver trouble treatment chronic hepatitis
The total routine number recovery from illness produce effects enabledisable total effective rate of group
Medicine taken after being mixed with boiling water for liver trouble group 156 38 68 34 16 89.74
Matched group 55 4 13 28 10 81.82
Through clinical observation, with Medicine taken after being mixed with boiling water for liver trouble treatment three months, HBSAg was all positive before 156 examples were controlled, and HBeAg positive person 44 examples are controlled back HBSAg negative conversion rate 57.5%, and it is 49.3% that HBeAg turns out cloudy, and total effective rate reaches 89.74%.
From zoopery and clinical application effect, Medicine taken after being mixed with boiling water for liver trouble is that a kind of HBSAg negative conversion rate is higher really, can effectively improve pathology, adjust body's immunity, be beneficial to the removing cause of disease, to the body HBV-DNA suppression ratio height of catching an illness, the good medicine of treatment hepatitis B evident in efficacy.
Below in conjunction with embodiment the present invention is further described:
Embodiment 1
Get Herba Artemisiae Scopariae 10kg, Radix Angelicae Sinensis 15kg after adding water 25kg and soaking into, places steam distillation unit, feeds steam and makes it to reach 0.2kg/cm
2, distilled out volatile oil 1.5 hours, it is standby to collect volatile oil, Herba Artemisiae Scopariae after the distillation, the Radix Astragali 15kg that Radix Angelicae Sinensis and other get, Radix Bupleuri 15kg, Radix Et Rhizoma Rhei 7kg, Polyporus 15kg, Radix Glycyrrhizae 5kg, Radix Ginseng 5kg, Fructus Gardeniae (parched to brown) 15kg, after Herba Hedyotidis Diffusae 10kg mixes, place to decoct container adding clear water 452kg, 100 ℃ decocted 1 hour, filter, taking liquid is standby, and medicinal residues add clear water 339kg again, places to decoct 100 ℃ of decoctions of container 2 hours, filter, waste is with secondary medicinal liquid and Radix Angelicae Sinensis, Herba Artemisiae Scopariae volatile oil merges, and being concentrated into density with the circulation film concentrator is 1.2 o'clock, spray drying, packing is Medicine taken after being mixed with boiling water for liver trouble.
Embodiment 2
Get Herba Artemisiae Scopariae 20kg, after adding water 30kg and soaking into, place steam distillation unit, feed steam and make it to reach 0.2kg/cm
2, distilling out volatile oil 1.5 hours, to collect volatile oil standby, Herba Artemisiae Scopariae slag after the distillation and the Radix Astragali 30kg Radix Salviae Miltiorrhizae 15kg that other gets, Radix Bupleuri 10kg, Radix Et Rhizoma Rhei 10kg, Polyporus 7.5kg, Poria 7.5kg, Radix Glycyrrhizae 7.5kg, Radix Codonopsis 15kg, Radix Isatidis 10kg, Herba Sedi 20kg mixes to be placed on decocting adding clear water 610kg in the container, and 100 ℃ decocted 2 hours, filter, taking liquid is standby, and medicinal residues add clear water 457.5kg again, places to decoct 100 ℃ of decoctions of container 1 hour, filter, waste merges secondary medicinal liquid and Herba Artemisiae Scopariae volatile oil, medicinal liquid with the circulation film concentrator contract to density be 1.15 o'clock, spray drying, packing is Medicine taken after being mixed with boiling water for liver trouble.
Embodiment 3
Get Herba Artemisiae Scopariae 15kg, after adding water 22.5kg and soaking into, place steam distillation unit, feed steam and make it to reach 0.2kg/cm
2It is standby to distill out volatile oil (1.5 hours) collection volatile oil, Herba Artemisiae Scopariae slag after the distillation and the Radix Astragali 10kg that other gets, Radix Salviae Miltiorrhizae 10kg, Radix Bupleuri 13kg, Radix Et Rhizoma Rhei 12.5kg, Polyporus 10kg, Radix Glycyrrhizae 10kg, Radix Ginseng 5kg, Radix Codonopsis 5kg, Folium Isatidis 20kg is after Radix Cynanchi Paniculati 15kg mixes, place and decoct 100 ℃ of addings of container clear water 502kg, 100 ℃ decocted 1.5 hours, filtered, and taking liquid is standby, medicinal residues add clear water 376.5kg again, place to decoct 100 ℃ of decoctions of container 1.5 hours, filter waste, secondary medicinal liquid and Herba Artemisiae Scopariae volatile oil are merged, and it is spray drying packing in 1.1 o'clock that medicinal liquid concentrates in density with the circulation film concentrator.
Embodiment 4
Get Herba Artemisiae Scopariae 17.5kg, Radix Angelicae Sinensis 5kg after adding water 27kg and soaking into, places steam distillation unit, feeds steam and makes it to reach 0.2kg/cm
2It is standby to distill out volatile oil (1.5 hours) collection volatile oil, Herba Artemisiae Scopariae after the distillation, the Radix Astragali 25kg that Radix Angelicae Sinensis slag and other get, Radix Bupleuri 10kg, Radix Et Rhizoma Rhei 15kg, Poria 15kg, Radix Glycyrrhizae 10kg, Radix Ginseng 10kg, Herba Lysimachiae 15kg after cyrtomium fortunei 20kg mixes, places to decoct container adding clear water 570kg, 100 ℃ decocted 1.5 hours, filter, taking liquid is standby, and medicinal residues add clear water 427.5kg again, place and decoct 100 ℃ of decoctions of container 2 hours, filter waste, with secondary medicinal liquid and Herba Artemisiae Scopariae, Radix Angelicae Sinensis volatile oil merges, and it is 1.2 o'clock that medicinal liquid is concentrated into density with the circulation film concentrator, spray drying, packing is Medicine taken after being mixed with boiling water for liver trouble.
Embodiment 5
Get Herba Artemisiae Scopariae 12.5kg, Radix Angelicae Sinensis 3kg after adding water 18kg and soaking into, places steam distillation unit, feeds steam and makes it to reach 0.2kg/cm
2, volatile matter distillation oil 1.5 hours, it is standby to collect volatile oil, the Herba Artemisiae Scopariae after the distillation, Radix Angelicae Sinensis slag and the Radix Astragali 20kg that other gets, Radix Bupleuri 12.5kg, Radix Et Rhizoma Rhei 5kg, Poria 20kg, Radix Glycyrrhizae 5kg, Radix Codonopsis 10kg, Fructus Gardeniae (parched to brown) 5kg, Radix Salviae Miltiorrhizae 8kg, Radix Isatidis 5kg, Folium Isatidis 10kg, Herba Lysimachiae 5kg.Herba Hedyotidis Diffusae 5kg, Herba Sedi 5kg, Radix Cynanchi Paniculati 5kg, cyrtomium fortunei 5kg mixing is placed on to decoct and adds clear water 544kg in the container, 100 ℃ decoct filtration in 1 hour, taking liquid is standby, and medicinal residues add clear water 408kg again and place the decoction container to decoct 2 hours for 100 ℃, filter waste, secondary medicinal liquid and Herba Artemisiae Scopariae Radix Angelicae Sinensis volatile oil are merged, being concentrated into density with the circulation film concentrator is 1.15 o'clock, and the spray drying packing is Medicine taken after being mixed with boiling water for liver trouble.
Claims (6)
1, the Medicine taken after being mixed with boiling water for liver trouble that is used for the treatment of the hepatitis B disease, by some Chinese herbal medicine components and water through distillation, decoct, concentrate, drying forms, it is characterized in that containing following component: Radix Astragali 10-30 weight portion, Radix Ginseng 0-15 weight portion, Radix Codonopsis 0-15 weight portion, Radix Bupleuri 10-15 weight portion, Fructus Gardeniae (parched to brown) 0-20 weight portion, Radix Isatidis 0-20 weight portion, Folium Isatidis 0-20 weight portion, Herba Lysimachiae 0-20 weight portion, Radix Et Rhizoma Rhei 5-15 weight portion, Radix Angelicae Sinensis 0-15 weight portion, Radix Salviae Miltiorrhizae 0-15 weight portion, Herba Artemisiae Scopariae 10-20 weight portion, Polyporus 0-20 weight portion, Poria 0-20 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Hedyotidis Diffusae 0-20 weight portion, Herba Sedi 0-20 weight portion, Radix Cynanchi Paniculati 0-20 weight portion, cyrtomium fortunei 0-20 weight portion.
2,, it is characterized in that Radix Ginseng, Radix Codonopsis must not be zero simultaneously, and when using one or both, its total amount is no less than 5 weight portions, is not more than 15 weight portions according to the said Medicine taken after being mixed with boiling water for liver trouble of claim 1.
3, according to the said Medicine taken after being mixed with boiling water for liver trouble of claim 1, it is characterized in that Fructus Gardeniae (parched to brown), Radix Isatidis, Folium Isatidis, Herba Lysimachiae must not be zero simultaneously, when selecting one or more for use, its total amount must not be less than 10 weight portions, is not more than 25 weight portions.
4, according to the said Medicine taken after being mixed with boiling water for liver trouble of claim 1, it is characterized in that Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae must not be zero simultaneously, when selecting one or both for use, its total amount is no less than 5 weight portions, is not more than 15 weight portions.
5,, it is characterized in that Herba Hedyotidis Diffusae, Herba Sedi, Radix Cynanchi Paniculati, cyrtomium fortunei must not be zero simultaneously, and when selecting one or more for use, its total amount is no less than 10 weight portions, is not more than 20 weight portions according to the said Medicine taken after being mixed with boiling water for liver trouble of claim 1.
6,, it is characterized in that Polyporus, Poria must not be zero simultaneously, and when selecting one or both for use, its total amount is no less than 10 weight portions, is not more than 20 weight portions according to the said Medicine taken after being mixed with boiling water for liver trouble of claim 1.
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| CN1049834C (en) * | 1995-09-25 | 2000-03-01 | 曾宽生 | Medicine for curing hepatitis and its prepn process |
| CN1052413C (en) * | 1994-01-17 | 2000-05-17 | 江洋 | Yinhuang Ganfu powder for curing hepatitis |
| CN1053375C (en) * | 1996-05-27 | 2000-06-14 | 刘智华 | Chinese medicine preparation for hepatosis |
| CN1066951C (en) * | 1997-09-04 | 2001-06-13 | 田丽华 | Traditional Chinese powder medicine for hepatosis |
| CN1081067C (en) * | 1999-12-06 | 2002-03-20 | 黄培乐 | Chinese medicine prescription for curing hepatitis, cholangitis, pancreatitis and cirrhosis |
| CN1083721C (en) * | 1999-03-29 | 2002-05-01 | 首都医科大学附属北京友谊医院 | Compound Chinese herb medicine for curing fibrosis of liver and hepatocirrhosis and its preparation method |
| CN101143169B (en) * | 2007-09-04 | 2010-06-09 | 张树保 | Traditional Chinese medicine preparation for curing peritoneal inflammation or pleural inflammation and its preparation method |
| CN101342249B (en) * | 2008-08-29 | 2010-12-08 | 陕西东泰制药有限公司 | Chinese medicine formulations for treating hepatitis B and preparation method thereof |
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- 1993-01-19 CN CN93110854A patent/CN1065750C/en not_active Expired - Lifetime
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| CN1052413C (en) * | 1994-01-17 | 2000-05-17 | 江洋 | Yinhuang Ganfu powder for curing hepatitis |
| CN1049834C (en) * | 1995-09-25 | 2000-03-01 | 曾宽生 | Medicine for curing hepatitis and its prepn process |
| CN1053375C (en) * | 1996-05-27 | 2000-06-14 | 刘智华 | Chinese medicine preparation for hepatosis |
| CN1066951C (en) * | 1997-09-04 | 2001-06-13 | 田丽华 | Traditional Chinese powder medicine for hepatosis |
| CN1083721C (en) * | 1999-03-29 | 2002-05-01 | 首都医科大学附属北京友谊医院 | Compound Chinese herb medicine for curing fibrosis of liver and hepatocirrhosis and its preparation method |
| CN1081067C (en) * | 1999-12-06 | 2002-03-20 | 黄培乐 | Chinese medicine prescription for curing hepatitis, cholangitis, pancreatitis and cirrhosis |
| CN101143169B (en) * | 2007-09-04 | 2010-06-09 | 张树保 | Traditional Chinese medicine preparation for curing peritoneal inflammation or pleural inflammation and its preparation method |
| CN101342249B (en) * | 2008-08-29 | 2010-12-08 | 陕西东泰制药有限公司 | Chinese medicine formulations for treating hepatitis B and preparation method thereof |
| CN101385842B (en) * | 2008-10-14 | 2010-12-29 | 王林兴 | Medicine for treating chronic hepatitis b and preparation method thereof |
| CN102228648A (en) * | 2011-06-27 | 2011-11-02 | 武红莲 | Chinese medicinal composition for treating icterohepatitis |
| CN102228648B (en) * | 2011-06-27 | 2012-09-26 | 武红莲 | Chinese medicinal composition for treating icterohepatitis |
| CN104161853A (en) * | 2013-08-30 | 2014-11-26 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating livestock and poultry hepatitis and preparation method thereof |
| CN103463375A (en) * | 2013-09-04 | 2013-12-25 | 中国人民解放军济南军区联勤部药品仪器检验所 | Traditional Chinese medicine composition for treating chronic type viral hepatitis B |
| CN103463375B (en) * | 2013-09-04 | 2015-01-28 | 中国人民解放军济南军区联勤部药品仪器检验所 | Traditional Chinese medicine composition for treating chronic type viral hepatitis B |
| CN108671086A (en) * | 2018-06-23 | 2018-10-19 | 吴安相 | A kind of the Dong nationality's Chinese medicine preparation for treating chronic persistant hepatitis |
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