CN107648060A - A kind of facial mask without preservative - Google Patents
A kind of facial mask without preservative Download PDFInfo
- Publication number
- CN107648060A CN107648060A CN201710870904.3A CN201710870904A CN107648060A CN 107648060 A CN107648060 A CN 107648060A CN 201710870904 A CN201710870904 A CN 201710870904A CN 107648060 A CN107648060 A CN 107648060A
- Authority
- CN
- China
- Prior art keywords
- facial mask
- acid
- preservative
- derivative
- preservative according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003755 preservative agent Substances 0.000 title claims abstract description 27
- 230000002335 preservative effect Effects 0.000 title claims abstract description 27
- 230000001815 facial effect Effects 0.000 title claims abstract description 24
- 239000003792 electrolyte Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- 239000002738 chelating agent Substances 0.000 claims abstract description 5
- 239000003002 pH adjusting agent Substances 0.000 claims abstract description 5
- 239000000049 pigment Substances 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- -1 polyglycereol Polymers 0.000 claims description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 229920002674 hyaluronan Polymers 0.000 claims description 5
- 229960003160 hyaluronic acid Drugs 0.000 claims description 5
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 5
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 4
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000001540 sodium lactate Substances 0.000 claims description 4
- 229940005581 sodium lactate Drugs 0.000 claims description 4
- 235000011088 sodium lactate Nutrition 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 244000241257 Cucumis melo Species 0.000 claims description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 229960005188 collagen Drugs 0.000 claims description 2
- 239000000084 colloidal system Substances 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- 239000004519 grease Substances 0.000 claims description 2
- 229940051250 hexylene glycol Drugs 0.000 claims description 2
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 2
- 150000008040 ionic compounds Chemical class 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims description 2
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 2
- 229960003330 pentetic acid Drugs 0.000 claims description 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- 229930194542 Keto Natural products 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 150000003235 pyrrolidines Chemical class 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 3
- 206010000496 acne Diseases 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 2
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 101000748141 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 32 Proteins 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 102100040050 Ubiquitin carboxyl-terminal hydrolase 32 Human genes 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 229940124274 edetate disodium Drugs 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 241000235342 Saccharomycetes Species 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 description 2
- 235000011151 potassium sulphates Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- ODHCTXKNWHHXJC-UHFFFAOYSA-N 5-oxoproline Chemical compound OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000004500 asepsis Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of facial mask without preservative, each raw materials by weight is composed of the following components in the face pack prescription：Electrolyte 10%~60%, NMF 0.01%~50%, thickener 0.01%~5%, essence 0.01%~2%, pigment 0%~2%, pH adjusting agent 0~2%, chelating agent 0%~2%, functional components 0.01%~60%, surplus are water.The present invention provides a kind of facial mask without preservative, it is entirely avoided negative effect of the preservative to human body in facial mask, and assign facial mask natural gentle sterilizing and itch-relieving acne-removing.
Description
Technical field
The present invention relates to a kind of facial mask without preservative, belong to cosmetic technical field.
Background technology
Facial mask contains abundant nutrients due to that can not accomplish integral asepsis in production, packaging process in facial mask
Matter, this provides good hotbed for bacteria breed, therefore, preservative must be added in facial mask, otherwise easily because bacterium grows
Give birth to and cause to go bad.Product after rotten often occurs pungent or allows the offending smell of people, or causes consumer's allergy, produces
It is raw to stimulate.But there is increasing scientific experiment to confirm that the preservative in facial mask easily causes allergy and contact dermatitis, part
Preservative can also induce breast cancer, therefore, as consumption upgrading and the raising of consumer spending consciousness, no anti-corrosion have become
Consumer selects important trend of facial mask.
And under the conditions of existing for high concentration electrolyte, due to the infiltration of microorganism and the intracellular protein solution of bacterium
Pressure is much smaller than the osmotic pressure of extracellular electrolyte, and now, the intracellular hydrone of microorganism and bacterium can then pass through cell membrane
A side small from osmotic pressure penetrates into the big side of osmotic pressure, that is, is penetrated into out of cell membrane outside cell membrane, and cell is therefore
And it is dehydrated lethal.Thus, the electrolyte of high concentration has the effect of anti-corrosion.
But the electrolyte of high concentration can destroy the stability of face pack prescription so that facial mask is easily layered, and therefore, is ground in formula
Need carefully to assess the stability of formula during hair.Suitable raw material is only selected to be compounded, its stability is
It can be up to state standards.
The facial mask being up to state standards containing high concentration electrolyte and stability, can effectively prevent microorganism and bacterium
Growth, so as to no longer need to add preservative, completely eliminate and negatively affect caused by preservative.Meanwhile these are electrolysed
Matter can also gently kill face bacterium, have fine effect for scytitis, long acne etc..
The content of the invention
It is an object of the present invention to provide a kind of facial mask without preservative.
Technical scheme：In a kind of face pack prescription without preservative, by weight percentage by following components group
Into：
Electrolyte 10%~70%,
NMF 0.01%~50%,
Thickener 0.01%~5%,
Essence 0.01%~2%,
Pigment 0%~2%,
PH adjusting agent 0~2%,
Chelating agent 0%~2%,
Functional components 0.01%~60%,
Surplus is water.
Further, described electrolyte is ionic compound soluble in water.
Further, it is sweet to include glycerine, propane diols, butanediol, pentanediol, hexylene glycol, ethylhexyl for described NMF
Oil, D-sorbite, xylitol, sodium hyaluronate, white fungus hyaluronic acid, hyaluronic acid, collagen, trehalose, ceramide, poly- second
One or more in glycol, polyglycereol, polyaminoacid, urea, sodium lactate, 2-pyrrolidone-5-carboxylic acid.
Further, described thickener includes cellulose thickener, acrylic acid and methacrylic acid derivative class, formed sediment
One or more in powder class, melon glue and its derivative, vegetalitas colloid class, polyoxyethylene.
Further, described pH adjusting agent is citric acid, citrate, lactic acid, sodium lactate, hydrochloric acid, sulfuric acid, phosphoric acid hydrogen
Disodium, sodium dihydrogen phosphate, sodium hydroxide, potassium hydroxide or triethanolamine the aqueous solution in one or more.
Further, described chelating agent include ethylenediamine tetra-acetic acid and its salt, diethylene-triamine pentaacetic acid and its salt,
One or more in aminotriacetic acid.
Further, described functional components include plant extracts, animal extracts, grease and its derivative, dimension
One or more compositions in raw element and its derivative, phosphatide, amino acid, polypeptide, protein and its derivative.
Beneficial effects of the present invention：Preservative is instead of with the electrolyte of high concentration, it is therefore prevented that using with the addition of preservative
Facial mask caused by negative effect to skin of face and human body, have very well simultaneously for facial skin inflammation and long acne etc.
The effect of.
Embodiment
Further detailed description is done to the present invention in conjunction with the embodiments, but the implementation of the present invention is not limited to this.
Embodiment 1：
A kind of moisture saver mask for not adding preservative, it is composed of the following components：
Sodium sulphate 25%,
Potassium sulfate 5%,
Glycerine 10%,
Propane diols 2%,
Hyaluronic acid 0.5%,
Hydroxyethyl cellulose 0.5%,
Essence 0.1%,
Citric acid 0.05%,
EDETATE DISODIUM 0.1%,
Dried tremella extract 1%,
Surplus is water.
Embodiment 2：
A kind of cleawhite pack for not adding preservative, it is composed of the following components：
Potassium chloride 20%,
Sodium chloride 10%,
Glycerine 10%,
Propane diols 2%,
Hydroxyethyl cellulose 0.5%,
Essence 0.12%,
Citric acid 0.03%,
EDETATE DISODIUM 0.1%,
Ethyl vitamin C 1%,
Angelica Dahurica extract 1%,
Gotu Kola P.E 0.5%,
Surplus is water.
Embodiment 3：
A kind of Deacne pack for not adding preservative, it is composed of the following components：
Sodium chloride 35%,
Potassium sulfate 10%,
Glycerine 8%,
Propane diols 5%,
Hydroxyethyl cellulose 0.5%,
Essence 0.1%,
EDETATE DISODIUM 0.1%,
Dipotassium glycyrrhizinate 1%,
Allantoin 1%,
Salicylic acid 1%
Dried orange peel extracts 0.5%,
Surplus is water.
In order to verify the stability of face pack prescription, we use the stability test method in QB/T2872-2007 to reality
Apply example 1,2 and 3 and carried out stability test, acquired results are as shown in table 1.
Table 1
| Project | Experiment condition | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| It is heat-resisting | （40±1）DEG C keep 24h, recover to room temperature, with being contrasted before experiment | Without significant change | Without significant change | Without significant change |
| It is cold-resistant | （- 5~-10）DEG C keep 24h, recover to room temperature, with being contrasted before experiment | Without significant change | Without significant change | Without significant change |
The result of the test of table 1 illustrates that the stability of embodiment 1,2 and 3 has reached the requirement of national standard.
In order to verify the preservative efficacy of high concentration electrolyte, we use American Pharmacopeia USP32<51>To embodiment 1,2 and
3 have carried out antimicrobial preservation efficacy test, and acquired results are as shown in table 2.
Table 2
American Pharmacopeia USP32<51>Judgment criteria be：1）Total number of bacteria from initially to 14 days bacterial population log reduction not
2.0 can be less than, and from 14 days to 28 days, bacterial population can not increase；2）Mould is with saccharomycete sum from initially by 14 days and 28
My god, mould can not increase with saccharomycete.
According to American Pharmacopeia USP32<51>Judgment criteria, the experimental result in table 1 confirms the electrolysis mass-energy of high concentration
Effectively kill and suppress embodiment 1, embodiment 2 and implement all kinds of bacteriums in 3, embodiment 1, embodiment 2 and real can be caused
Any preservative need not be added in applying 3.
Claims (7)
1. a kind of facial mask without preservative, it is characterised in that composed of the following components by weight percentage：
Electrolyte 10%~70%,
NMF 0.01%~50%,
Thickener 0.01%~5%,
Essence 0.01%~2%,
Pigment 0%~2%,
PH adjusting agent 0~2%,
Chelating agent 0%~2%,
Functional components 0.01%~60%,
Surplus is water.
2. a kind of facial mask without preservative according to claim 1, it is characterised in that the electrolyte is soluble in water
Ionic compound in.
A kind of 3. facial mask without preservative according to claim 1, it is characterised in that the NMF include glycerine,
Propane diols, butanediol, pentanediol, hexylene glycol, Sensiva SC50, D-sorbite, xylitol, sodium hyaluronate, white fungus hyaluronic acid,
Hyaluronic acid, collagen, trehalose, ceramide, polyethylene glycol, polyglycereol, polyaminoacid, urea, sodium lactate, pyrrolidines
One or more in keto carboxylic acid.
4. a kind of facial mask without preservative according to claim 1, it is characterised in that the thickener includes cellulose
Class thickener, acrylic acid and methacrylic acid derivative class, starch, melon glue and its derivative, vegetalitas colloid class, polyoxy
One or more in vinyl.
5. a kind of facial mask without preservative according to claim 1, it is characterised in that the pH adjusting agent is lemon
Acid, citrate, lactic acid, sodium lactate, hydrochloric acid, sulfuric acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium hydroxide, potassium hydroxide or three
One or more in the aqueous solution of monoethanolamine.
6. a kind of facial mask without preservative according to claim 1, it is characterised in that the chelating agent includes ethylenediamine
One or more in tetraacethyl and its salt, diethylene-triamine pentaacetic acid and its salt, aminotriacetic acid.
7. a kind of facial mask without preservative according to claim 1, it is characterised in that the functional components, which include, plants
Thing extract, animal extracts, grease and its derivative, vitamin and its derivative, phosphatide, amino acid, polypeptide, protein and
One or more compositions in its derivative.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710870904.3A CN107648060A (en) | 2017-09-24 | 2017-09-24 | A kind of facial mask without preservative |
| PCT/CN2018/080780 WO2019056725A1 (en) | 2017-09-24 | 2018-03-28 | Preservative-free mask |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710870904.3A CN107648060A (en) | 2017-09-24 | 2017-09-24 | A kind of facial mask without preservative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107648060A true CN107648060A (en) | 2018-02-02 |
Family
ID=61131038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710870904.3A Pending CN107648060A (en) | 2017-09-24 | 2017-09-24 | A kind of facial mask without preservative |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN107648060A (en) |
| WO (1) | WO2019056725A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110615838A (en) * | 2019-08-14 | 2019-12-27 | 浙江珂瑞康生物医疗科技有限公司 | Sterile instant undenatured natural collagen freeze-dried product and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021243359A1 (en) | 2020-05-27 | 2021-12-02 | Mary Kay Inc. | Topical compositions and methods |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159753A (en) * | 1994-08-09 | 1997-09-17 | 普罗克特和甘保尔公司 | Anti-acne cosmetic compositions |
| CN1579364A (en) * | 2004-05-21 | 2005-02-16 | 云南盐化股份有限公司 | Emulsified salt type skin-cleaning product and its preparation method |
| CN1943548A (en) * | 2006-10-23 | 2007-04-11 | 邓天华 | Bamboo salt and bamboo salt cosmetics, detergent article and its preparing method |
| CN101011331A (en) * | 2007-01-17 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Dead sea salt hydrotherapy face pack |
| CN101011329A (en) * | 2006-12-14 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Mineral salt face cleaning pack |
| CN101011328A (en) * | 2006-12-26 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Dead sea mud therapy face pack |
| CN102319200A (en) * | 2011-09-28 | 2012-01-18 | 广东海洋大学 | Gracilaria algae facial mask and preparation method thereof |
| CN103720623A (en) * | 2013-12-26 | 2014-04-16 | 南宁市化工研究设计院 | Method for preparing medical-stone bamboo-salt skin-strengthening agent |
| CN105616172A (en) * | 2016-01-19 | 2016-06-01 | 广州市美姿贺化妆品有限公司 | Pure mulberry silk facial mask and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167691A (en) * | 2007-10-30 | 2008-04-30 | 张定忠 | Method for preparing natural oblongas juice beautifying face pack |
| US9693936B2 (en) * | 2012-03-07 | 2017-07-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Dispersions in oil of Dead Sea nano sized material preparation and uses therof |
| CN104173203B (en) * | 2013-05-28 | 2018-10-16 | 拜尔斯道夫股份有限公司 | Low-irritation skin massage product |
-
2017
- 2017-09-24 CN CN201710870904.3A patent/CN107648060A/en active Pending
-
2018
- 2018-03-28 WO PCT/CN2018/080780 patent/WO2019056725A1/en active Application Filing
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159753A (en) * | 1994-08-09 | 1997-09-17 | 普罗克特和甘保尔公司 | Anti-acne cosmetic compositions |
| CN1579364A (en) * | 2004-05-21 | 2005-02-16 | 云南盐化股份有限公司 | Emulsified salt type skin-cleaning product and its preparation method |
| CN1943548A (en) * | 2006-10-23 | 2007-04-11 | 邓天华 | Bamboo salt and bamboo salt cosmetics, detergent article and its preparing method |
| CN101011329A (en) * | 2006-12-14 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Mineral salt face cleaning pack |
| CN101011328A (en) * | 2006-12-26 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Dead sea mud therapy face pack |
| CN101011331A (en) * | 2007-01-17 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Dead sea salt hydrotherapy face pack |
| CN102319200A (en) * | 2011-09-28 | 2012-01-18 | 广东海洋大学 | Gracilaria algae facial mask and preparation method thereof |
| CN103720623A (en) * | 2013-12-26 | 2014-04-16 | 南宁市化工研究设计院 | Method for preparing medical-stone bamboo-salt skin-strengthening agent |
| CN105616172A (en) * | 2016-01-19 | 2016-06-01 | 广州市美姿贺化妆品有限公司 | Pure mulberry silk facial mask and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王淑君: "《美容产品制剂学》", 29 February 2012, 辽宁科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110615838A (en) * | 2019-08-14 | 2019-12-27 | 浙江珂瑞康生物医疗科技有限公司 | Sterile instant undenatured natural collagen freeze-dried product and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019056725A1 (en) | 2019-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102631304B (en) | Preparation method of shampoo salt emulsion | |
| CN112656732A (en) | Dandruff-removing and itching-relieving shampoo and preparation method thereof | |
| CN107296771A (en) | A kind of desquamation compositions and extra quality multiple-effect are without silicone oil shampoo | |
| CN106109326B (en) | A kind of anti-bacteria wet keeping facial mask and preparation method thereof containing plant extracts | |
| CN106727097A (en) | A kind of natural cosmetics anticorrosive composite with strong effect wide-spectrum bacteriostatic activity | |
| CN115569105B (en) | Composition containing rice hull extract for removing dandruff, controlling oil, inhibiting bacteria and removing mites | |
| CN112006954B (en) | Shampoo and preparation method thereof | |
| CN108042578A (en) | A kind of health care vaginal jellies containing compound probiotic ingredient | |
| CN109364006A (en) | A kind of acne-removing composition, Essence and preparation method thereof | |
| CN103054775A (en) | Environmentally-friendly sterilization and moisture retention hand cleanser | |
| CN107582459B (en) | A kind of preservative and preparation method thereof containing Fructus Forsythiae | |
| CN107648060A (en) | A kind of facial mask without preservative | |
| CN108210370A (en) | The facial mask essence and its facial mask and preparation method of a kind of citrus pectin ingredient | |
| CN106109264B (en) | A kind of facial treatment mask and preparation method thereof with anti-bacteria wet keeping function | |
| CN102688158A (en) | Additive-free anti-aging cosmetic and preparation method thereof | |
| CN105997535A (en) | Personal care formula without preservative | |
| CN111067820A (en) | Plant repair essence milk and preparation method thereof | |
| CN107375152A (en) | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel | |
| CN105267060A (en) | Silver-based anti-dandruff shampoo and preparation method thereof | |
| CN106511190A (en) | Hair conditioner without preservative | |
| KR101598083B1 (en) | An antifungal composition comprising an natural fermentation material | |
| KR20200060890A (en) | The shampoo composition comprising extract of natural micro organism-fermented black ginseng | |
| CN109674702B (en) | Clove compound natural preservative, preparation method and application in cosmetics | |
| CN109662926A (en) | A kind of polywater moisturizing essence dew and preparation method thereof | |
| CN107961209A (en) | A kind of skin care item of whitening anti-aging and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wu Huabing Inventor after: Liang Yao Inventor after: Zhan Kai Inventor after: Zhao Yingxiang Inventor after: Yu Qi Inventor before: Wu Huabing |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180214 Address after: 410000 Changsha City, Hunan province high tech Development Zone, Yuelu Avenue West, No. 588, Changsha core city science and Technology Park, building 6, building 6 Applicant after: China Polytron Technologies Inc Address before: 410000 room B4088 of Tianma village University of Tianma village, Changsha City, Yuelu District, Hunan Applicant before: Changsha Huachen Biotechnology Co., Ltd. |
|
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180725 Address after: 410000 Xiaoxiang Road, Tianma Road, Tianma Road, Hunan, Changsha, Yuelu District, B4088 Applicant after: Changsha Huachen Biotechnology Co., Ltd. Address before: 410000 6, 6 Changsha road core technology park, 588 Yuelu Avenue West, Changsha high tech Development Zone, Hunan. Applicant before: China Polytron Technologies Inc |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180202 |