CN107638363A - A kind of bacteriostatic tooth protective toothpaste and preparation method thereof - Google Patents

Abstract

The invention relates to an antibacterial toothpaste and a preparation method thereof, which is composed of the following raw materials in parts by weight: 5-10 parts of adhesive, 10-16 parts of wetting agent, 2-4 parts of surfactant, and 0.5 parts of flavoring agent ‑2 parts, propolis 1‑5 parts, chitosan 0.5‑15 parts, deionized water 10‑35 parts. The bacteriostatic toothpaste of the present invention not only has good bacteriostatic and bactericidal effects, but also can effectively avoid damage to teeth and oral cavity caused by mineral abrasives in traditional toothpaste, and has a simple preparation process.

Description

A kind of antibacterial toothpaste and preparation method thereof

technical field

The invention relates to a toothpaste and a preparation method thereof, in particular to an antibacterial toothpaste and a preparation method thereof, belonging to the technical field of oral health care.

Background technique

Toothpaste is a commonly used cleaning product in daily life. The toothpaste currently on the market can be roughly divided into three categories: whitening, anti-inflammatory and antibacterial and anti-moth toothpaste. With the improvement of people's requirements for oral hygiene, there are more and more types of toothpaste with antibacterial effect. The general antibacterial toothpaste achieves the purpose of antibacterial by adding active ingredients such as antibacterial agents. Long-term use will cause certain side effects on the body. Ordinary whitening toothpaste achieves whitening and cleaning effects on teeth by adding abrasives such as silicon dioxide, and it will cause damage to teeth and oral cavity if used for a long time.

Therefore, how to provide a toothpaste that can effectively avoid damage to teeth and oral cavity, has good antibacterial properties and has no toxic side effects on the body is an urgent problem to be solved by those skilled in the art.

Contents of the invention

In order to solve the above technical problems, the present invention provides an antibacterial toothpaste with multiple functions of whitening, antibacterial and tooth protection.

The technical scheme that the present invention solves the problems of the technologies described above is as follows:

An antibacterial toothpaste for tooth protection, which consists of the following raw materials in parts by weight: 5-10 parts of adhesive, 10-16 parts of wetting agent, 2-4 parts of surfactant, 0.5-2 parts of flavoring agent, 1-2 parts of propolis 5 parts, chitosan 0.5-15 parts, deionized water 10-35 parts.

The present invention adopts the antibacterial toothpaste prepared according to the above-mentioned components, which can significantly alleviate the symptoms of itchy gums, gum discomfort, gum distending pain, bad breath, bleeding gums, color changes of gums, and bleeding on probing. The efficiency can reach 100%; its antibacterial effect is more significant than that of ordinary toothpaste without adding chitosan or propolis, and can reach more than twice the antibacterial effect of ordinary toothpaste.

On the basis of above-mentioned technical scheme, the present invention can also be improved as follows:

Preferably, the binder is one or more of sodium carboxymethylcellulose, xanthan gum, hydroxyethylcellulose, guar gum and carrageenan.

Preferably, the wetting agent is one or more of sorbitol, glycerin and propylene glycol.

Preferably, the surfactant is one or more of sodium lauryl sulfate, sodium stearate and sodium dodecylbenzenesulfonate.

Preferably, the flavoring agent is one or more of peppermint essence, xylitol and fructooligosaccharides.

Preferably, the chitosan has a molecular weight of 300,000D-500,000D.

The present invention also provides a kind of preparation method of antibacterial toothpaste, technical scheme is as follows:

Step (1): Weigh the above-mentioned raw materials respectively, put chitosan into the paste-making pot, pump in adhesive and wetting agent, and stir evenly at room temperature;

Step (2): Add deionized water, propolis and flavoring agent to the evenly stirred mixture in step (1), turn on the scraper and stirrer to stir, and stir continuously for 25-35 minutes;

Step (3): Add surfactant to the material stirred in step (2), continue stirring for 13-17 minutes, and then discharge the material to obtain the antibacterial toothpaste.

In the above-mentioned a kind of antibacterial toothpaste, the effect that each component plays in the present invention is:

Chitosan: The elastic particles formed after chitosan is swelled by water is a high-quality friction material, which can replace the friction agents such as silicon dioxide and calcium carbonate in traditional toothpaste. It is less irritating to the oral cavity and can Avoid damage to the smoothness of the tooth surface during the long-term use of abrasives, resulting in tooth discoloration and corrosion; in addition, chitosan also has the characteristics of good entrance performance and excellent antibacterial performance.

Propolis: Propolis is a colloidal solid made from the resin collected by bees from plant spores or tree trunks, mixed with the secretions of their mandibular glands and wax glands. It has a special aromatic smell and can be added to toothpaste. Improve the entrance performance of toothpaste and has good antibacterial, anti-inflammatory, antipruritic, anti-oxidant, immune-enhancing, hypoglycemic and other functions; secondly, as a naturally formed substance with antibacterial properties, it replaces the antibacterial agents in ordinary toothpaste. There are no side effects.

Binder: Make the ingredients in the toothpaste evenly dispersed.

Wetting agent: prevent the toothpaste from curing and hardening in the tube after molding, which will affect the use effect, and make the paste have gloss and other effects.

Surfactant: Sodium lauryl sulfate acts as a neutral detergent, which can not only foam quickly, but also remove dirt in the mouth.

Fragrance agent: improve the entrance performance of toothpaste, make the taste sweet and fresh breath.

Compared with common toothpaste, the present invention has the following advantages:

1. The elastic particles formed after chitosan is swollen with water are used as the main grinding agent, which can remove the attachments and plaque of the teeth well during the process of brushing teeth, and has a very excellent adsorption cleaning effect, and has excellent Excellent antibacterial performance, mild and non-irritating to the oral cavity, and has good entrance performance.

2. Propolis is used as the main antibacterial substance, which not only tastes fragrant, but also can effectively inhibit and kill pathogenic bacteria, viruses, protozoa, etc., thereby effectively inhibiting the occurrence of gingivitis and periodontal disease, and preventing Human body without any side effects.

3. The preparation process of the present invention is simple, and the raw materials used are simple and easy to obtain, and the obtained product has stable performance, obvious antibacterial effect and whitening effect, and is a toothpaste worthy of popularization.

detailed description

The principles and features of the present invention are described in conjunction with the following examples, which are only used to explain the present invention, and are not intended to limit the scope of the present invention.

The embodiment of the invention discloses an antibacterial toothpaste and a preparation method thereof.

Embodiment one

The antibacterial toothpaste in this embodiment is prepared from the raw materials of the following weights, including: 50 grams of sodium carboxymethyl cellulose, 100 grams of sorbitol, 20 grams of sodium lauryl sulfate, 5 grams of peppermint essence, and 10 grams of propolis gram, 5 grams of chitosan, 100 grams of deionized water; the molecular weight of chitosan is 300,000 D-500,000 D.

The preparation method of above-mentioned antibacterial toothpaste is as follows:

Step (1): Weigh each component in Example 1 respectively, put chitosan into the paste making pot, pump sodium carboxymethylcellulose and sorbitol into it, and stir evenly at room temperature;

Step (2): Add deionized water, propolis and mint essence to the mixture that has been stirred evenly in step (1), turn on the scraper and agitator to stir, and continue to stir for 20-35 minutes;

Step (3): Add sodium lauryl sulfate to the material stirred in step (2), and continue stirring for 13-17 minutes before discharging to obtain the antibacterial toothpaste.

Embodiment two

The antibacterial toothpaste of this embodiment is formulated by the raw material of following weight: 80 grams of xanthan gum, 130 grams of propylene glycol, 30 grams of sodium lauryl sulfate, 10 grams of xylitol, 15 grams of propolis, 100 grams of chitosan , 150 grams of water.

Embodiment three

The antibacterial toothpaste of this embodiment is prepared from the following raw materials: 60 grams of sodium carboxymethylcellulose, 40 grams of hydroxyethyl cellulose, 150 grams of glycerin, 30 grams of sodium lauryl sulfate, 10 grams of xylitol gram, propolis 20 grams, chitosan 200 grams, deionized water 350 grams.

Embodiment four

The antibacterial toothpaste of this embodiment is prepared from the following raw materials: 50 grams of sodium carboxymethyl cellulose, 50 grams of sorbitol, 50 grams of glycerin, 10 grams of sodium lauryl sulfate, 5 grams of xylitol, propolis 10 grams, 50 grams of chitosan, 100 grams of deionized water.

Embodiment five

The antibacterial toothpaste of this embodiment is prepared from the following raw materials: 30 grams of guar gum, 50 grams of carrageenan, 70 grams of sorbitol, 60 grams of glycerin, 15 grams of sodium stearate, 10 grams of peppermint essence, propolis 15 grams, chitosan 100 grams, deionized water 200 grams.

Embodiment six

The antibacterial toothpaste of this embodiment is prepared from the following raw materials: 100 grams of xanthan gum, 50 grams of sorbitol, 100 grams of glycerin, 25 grams of sodium lauryl sulfate, 5 grams of peppermint essence, and 5 grams of xylitol , 30 grams of propolis, 200 grams of chitosan, 300 grams of deionized water.

Embodiment seven

The antibacterial toothpaste of this embodiment is prepared from the following raw materials: 20 grams of hydroxyethyl cellulose, 30 grams of guar gum, 100 grams of propylene glycol, 10 grams of sodium lauryl sulfate, 5 grams of fructooligosaccharides, propolis 10 grams, 5 grams of chitosan, 100 grams of deionized water.

Embodiment Eight

The antibacterial toothpaste of this embodiment is prepared from the following raw materials: 80 grams of hydroxyethyl cellulose, 80 grams of sorbitol, 50 grams of propylene glycol, 15 grams of sodium stearate, 100 grams of mint saccharin, 15 grams of propolis, Chitosan 100 grams, deionized water 150 grams.

Embodiment nine

The antibacterial toothpaste of this embodiment is prepared from the following raw materials: 50 grams of xanthan gum, 50 grams of carrageenan, 100 grams of sorbitol, 50 grams of glycerin, 25 grams of sodium lauryl sulfate, 100 grams of mint saccharin, 20 grams of propolis, 200 grams of chitosan, 300 grams of deionized water.

The function and performance of the present invention will be further elaborated below through tests.

Test 1: Anti-inflammatory test

All the cases of this test are gingivitis patients, and experimental group one to test group nine adopts the toothpaste in embodiment one to embodiment nine to brush teeth every day sooner or later; ;Compare ten groups of symptoms and signs improvement after 7 days of treatment, and the evaluation criteria are as follows:

1. Efficacy evaluation of gum itching, discomfort, pain and bad breath:

Significantly effective: the symptoms are significantly improved or disappeared, and the patient is satisfied;

Effective: the symptoms are improved or alleviated, but the patient still feels unwell and requires continued treatment;

Ineffective: the symptoms are not significantly relieved, and the patient is not satisfied.

2. Signs and curative effect evaluation:

Significantly effective: the three signs of bleeding gums, gum color change, and bleeding on probing all improved;

Effective: The two signs of gum bleeding and gum color improved, but bleeding on probing did not improve;

Invalid: None of the 3 signs of bleeding gums, gum color, and bleeding on probing were improved.

The improvement of symptoms after 7 days is shown in Table 1:

Table 1 Anti-inflammatory test evaluation data

markedly effective efficient invalid total effective rate Test group one 10 0 0 100% Test group two 8 2 0 100% Test group three 7 3 0 100% Test group four 9 1 0 100% Experimental group five 9 1 0 100% Test group six 8 2 0 100% Experimental group seven 10 0 0 100% Test group eight 8 2 0 100% Test group nine 9 1 0 100% Test group ten 0 4 6 40%

According to Test 1, it can be concluded that the toothpaste added with chitosan can effectively prevent the damage of teeth and oral cavity, and play a good anti-inflammatory effect.

Test 2: Antibacterial test

1, experimental material: the toothpaste in embodiment one to embodiment nine and the toothpaste that does not add propolis;

2. Types of bacteria to be tested: Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus and Candida albicans;

3. Bacterial culture medium: the bacterial culture medium is tryptic soybean broth medium; the preparation method is: 30 g of tryptic soybean broth powder, 15 g of basic agar, and 1 L of sterilized depyrogenated water.

4. Bacterial culture solution: the bacterial culture solution is 200 mL of 3% tryptic soybean broth; the preparation method is: 6 g of tryptic soybean broth powder plus 200 mL of sterilized depyrogenated water.

5. Test method:

This test adopts the diffusion method: the toothpaste of each test group adopts two concentrations of about 50 mg in paste form and 1:1 diluted form with sterilized depyrogenated water.

①. Spread the bacterial culture solution evenly on the culture medium of the petri dish, place the petri dish in a constant temperature incubator at 37°C for 24 hours, and cultivate 10 petri dishes for each type of bacteria;

②. Spread 50 mg of toothpaste in each of the 10 test groups evenly on the small round filter paper; in addition, drop the 10 groups of dilutions and sterilized depyrogenated water in equal amounts on the small round filter paper with a 10 μL capillary dropper. .

③. Attach three small round filter paper sheets with the same concentration of the same toothpaste and sterilized depyrogenated water evenly and symmetrically to the central area of the culture medium. concentrations were tested.

4. Finally, the petri dish was placed in a constant temperature incubator at 37° C. for 24 h, and the diameter of the inhibition zone was measured (in mm), the test was repeated 5 times, and the average value of the 5 tests was taken as the diameter of the inhibition zone.

6. Test results:

The test results are shown in Table 2:

Table 2 Antibacterial test data

It can be seen from Table 2 that the bacteriostatic toothpaste prepared by the present invention has significant inhibitory effect on Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus and Candida albicans, while the comparative examples and the preparations of Examples 1 to 9 of the present invention Compared with the bacteriostatic toothpaste, the bacteriostatic effect of toothpaste is poor, thus it can be concluded that the interaction between the components of the present invention can enhance the bacteriostatic effect.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection of the present invention. within range.

Claims (7)

1. a kind of bacteriostatic tooth protective toothpaste, it is characterised in that be made up of the raw material of following parts by weight：Adhesive 5-10 parts, wetting agent 10-16 parts, surfactant 2-4 parts, flavouring agent 0.5-2 parts, propolis 1-5 parts, chitosan 0.5-15 parts, deionized water 10-35 Part.

2. a kind of bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that described adhesive is carboxymethyl cellulose One kind or any several in sodium, xanthans, hydroxyethyl cellulose, guar gum and carragheen.

3. a kind of bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that the wetting agent is sorbierite, glycerine With one kind in propane diols or any several.

4. a kind of bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that the surfactant is laruyl alcohol sulphur One kind or any several in acid esters sodium, odium stearate and neopelex.

5. a kind of bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that the flavouring agent is Mint Essence, wood One kind or any several in sugar alcohol and FOS.

A kind of 6. bacteriostatic tooth protective toothpaste according to any one of claim 1 to 5, it is characterised in that point of the chitosan Son amount is the D of 300,000 D-50 ten thousand.

7. a kind of preparation method of bacteriostatic tooth protective toothpaste, it is characterised in that comprise the following steps：

Step (1)：The raw material of any one of claim 1 to 5 bacteriostatic tooth protective toothpaste is weighed respectively, and chitosan is put into cream processed In pot, adhesive and wetting agent are pumped into, stirring at normal temperature is uniform；

Step (2)：Deionized water, propolis and flavouring agent are added in mixture after being stirred to step (1), open scraper plate and Agitator is stirred, and continuously stirs 25-35 minutes；

Step (3)：Surfactant is put into material after being stirred to step (2), continues to discharge after stirring 13-17 minutes, i.e., Obtain described bacteriostatic tooth protective toothpaste.