CN107616490A - A kind of postoperative tailored version clinical nutrition formula of children and preparation method thereof - Google Patents
A kind of postoperative tailored version clinical nutrition formula of children and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of postoperative tailored version clinical nutrition formula of children, it includes the component of following parts by weight：Protein, fat, carbohydrate, water-soluble dietary fiber, macroelement, trace element, liposoluble vitamin, water soluble vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resource food；The invention further relates to the preparation method of above-mentioned clinical nutrition formula, powder is made in its each component in advance, and powder is made using alcohol extracting water extraction concentration, spray drying in integration of drinking and medicinal herbs composition, and vitamin and fat are handled by microencapsulation is made powder；Or powder is made to each component progress emulsifying homogeneous, spray drying by wet processing.Screening and proportioning by said components, nutrient formulation of the present invention provides reasonable, comprehensive nutritional support for postoperative puerilism patient, addition simultaneously is with the integration of drinking and medicinal herbs composition for adding anti-infective enhancing immunologic function, the incidence probability of infection complication is reduced, promotes patient's rehabilitation as early as possible.
Description
Technical field
The present invention relates to special medicine purposes formula food field, and in particular to a kind of postoperative tailored version clinical nutrition of children
Formula and preparation method thereof.
Background technology
It is postoperative to cause endocrine and the change of metabolic process, though being advantageous to the tolerance to wound, can cause to seek in vivo
Material is supported highly to consume.Postoperative short-term height nutrient consumption, if supplementing the nutrients in time, reaches positive nitrogen equilibrium, can reduce as early as possible
Infection and complication, make wound heal rapidly.Infant is postoperative due to resistance decline, pain, consumption and absorption function decline etc.
Reason, it is impossible to normally feed and take in enough nutrients；Meanwhile may be right because of the loss of heating, a large amount of body fluid or diffusate
The increase of the nutrient requirement such as heat energy and protein.As infant can not obtain the supply of nutrient timely and reasonably, then can occur
Severe malnutrition, and then influence immunologic function and wound healing.
Children are postoperative be in growth, development during, systemic organs and Physique growth, development are all in immature rank
Section, gastrointestinal function is weaker, has certain particular/special requirement to the quality and quantity of food.Food will be adjusted suitably, accomplish to seek
It is appropriate to support plain ratio, it is 25% that heat energy of often eating, which distributes breakfast, Chinese meal 35%, dessert 10%, dinner 30%.
Malnutrition is a major issue in developing country, and same developed country is there is also this problem, in U.S. youngster
The malnutritive incidence of section inpatient is 20%~40%.Due to catabolic reaction in wound and Post operation more than simple
Starvation, Preoperative nutritional support is bad and may influence postoperative body recovery and complication rate.Children are because of its physiopathologic spy
Different property, its needs to nutritional support are different from adult, in addition to disease or wound metabolism need, also need to consider less body
Body, nutrition deposit is limited, mushroom out, the liquid of height change needs, and also has the immature of some organs in neonate.Cause
This, when children are due to gastrointestinal function or bad other organ dysfunctions, infant nutrition need again be not satisfied, can develop rapidly for
Albumen-heat is malnutritive.Child nutrition is needed with adult's difference less, but baby, neonate and adult's difference are very big.Typically
Think that seralbumin is malnutritive in 28~35g/L prompting moderates, be severe malnutrition less than 28g/L.Neonatal blood
Albumin value is starched usually in the lower bound of normal value.
Enteral nutrition (Enteral Nutrition, EN) and parenteral nutrition (Total Parenteral Nutrition,
TPN) be all professional Medical Degree treatment important method, treatment surgical patients, improve peri-operation period nutrition, improve operation into
Power, reduction postoperative complications etc. have played important function, are described as the progress greatly of modern age clinical medical one.It is complete parenteral
The complication of nutrition is divided into three classes：Mechanicalness, infectivity and metabolic complication, the above two occur mainly in central vein nutrition
When.With intestinal mucosa atrophy, the exception of Intestinal Morphology and function, biliary system function caused by the prolonged application of parenteral nutrition
Disorder, and the problems such as body's immunity obstacle it is increasing so that enteral nutrition preparation in clinical practice increasingly
It is taken seriously, is particularly paid close attention in enteron aisle stress reaction and critical illness treatment by clinician, comparatively speaking, intestines
Interior nutrition EN security is more advantageous.
Therefore, while development can provide the basal nutrient element needed for postoperative children, and can reduces postoperative childhood infection
The incidence probability product of property complication has important value and wide market.
The content of the invention
The defects of it is an object of the invention to overcome in the prior art, there is provided a kind of postoperative tailored version clinical nutrition of children is matched somebody with somebody
Side and preparation method thereof, it adjusts postoperative children as the supplement postoperative required enteral nutrition preparation of children, particularly high-quality protein,
Strengthen immunity, the incidence probability of infection complication is reduced, reduce overall expenses in hospital.Nutrient refers to give people in food
Body provides energy, participation body forms and the chemical composition of regulation of physiological functions.Nutrition necessary to human body is known as protein, fat
Class, carbohydrate, mineral matter, vitamin, water, dietary fiber etc..Expert recommends, and children's breakfast, lunch and dinner energy is assigned as breakfast 25%, lunch
35%th, dinner 30%, tiffin 10%, the ratio that morning of children, noon, dinner energy supply ratio are recommended with expert in the present invention approach.
To achieve the above object, the present invention adopts the following technical scheme that：
First purpose of the present invention is to provide a kind of postoperative tailored version clinical nutrition formula of children, including following component and
Its parts by weight：15-22 parts protein, 9-13 parts fat, 40-55 parts carbohydrate, 7-10 parts dietary fiber, 0.7-1.2
Part macroelement, 0.01-0.04 parts trace element, 0.01-0.03 parts liposoluble vitamin, 0.1-0.2 parts water soluble vitamin,
0.05-4 part meals elite, 0.1-5 part integration of drinking and medicinal herbs composition, 0.1-3 part natural plants compounds and 0.005-2 parts newly provide
Source food.
In order to further optimize above-mentioned clinical nutrition formula, the technical measures that the present invention is taken also include：
Preferably, in above-mentioned nutrient formulation, protein, fat, the productivity ratio of carbohydrate are 15~20：25~
30：50~60；It is highly preferred that the productivity ratio of protein, fat, carbohydrate is 17：29：54.
Preferably, the protein be selected from PURE WHEY, soybean protein isolate, hydrolysis Isin glue collagen, whole milk powder,
At least one of dried whole-egg, lactoferrin, colostrum, amino acid, protein peptides；Wherein protein content is in whole milk powder
24wt%, fat content 34wt%, carbohydrate content 40wt%.
Wherein, the amino acid is selected from 1B-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy
At least one of glutamine, taurine, Valine, ILE, L-Leu；The protein peptides are selected from soy oligosaccharides
At least one of peptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide, laughable peptide, amino peptide, ovalbumin peptide.
It is highly preferred that the protein includes PURE WHEY, soybean protein isolate, whole milk powder, bovine colostrum, hydrolysis
Isin glue collagen, ocean fish oligopeptide, taurine.
Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures
At least one of fat, DHA, EPA, ARA, phosphatide, more specifically described fat include safflower seed oil, walnut oil, peanut oil,
Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm
Oil, butter, cream, lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil etc.；More preferably olive oil, soybean oil, coconut
Oil, perilla herb oil, medium chain triglyceride.
Preferably, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch, jade
At least two in rice starch；More preferably rock sugar, maltodextrin.
Preferably, the dietary fiber include inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose,
At least one of soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；It is highly preferred that the dietary fiber includes 6-8
Part water-soluble dietary fiber and 1-2 part insoluble diedairy fibers, specifically the dietary fiber include water-soluble dietary fiber
And soybean fiber.
Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate
At least one of with magnesium gluconate.
Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose
At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.
Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, vitamin
K1At least one of.
Preferably, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin
C, at least one of pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps
At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn
At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean
Powder, soy meal, at least one of navy bean powder；The potato class is mainly made up of common yam rhizome powder；The Vegetable powder be selected from carrot meal,
At least one of white radish powder, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae is selected from mushroom
At least one of powder, Kelp Powder and white fungus powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch；
The fish and shrimp are selected from least one of salmon powder and cod meal；The poultry meat is selected from chicken meal, powdered beef and pig
At least one of kidney powder；The fruits are in red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder
It is at least one；More preferably oatmeal, buckwheat, white radish powder, white fungus powder, powdered beef.
Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant
At least one of sterol, lycopene, resveratrol, allicin；More preferably l-cn.
Preferably, the integration of drinking and medicinal herbs composition is selected from Poria cocos, orange peel, honeysuckle, dandelion, Poria cocos, matrimony vine, sealwort, dragon
At least one of eye meat, jujube.
It is highly preferred that the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：0~1 part of orange peel, honeysuckle 0~1
Part, 0~1 part of dandelion, 0~1 part of Poria cocos, 0~1 part of matrimony vine, 0~1 part of sealwort, 0~1 part of arillus longan, 0~1 part of jujube.
Preferably, the new resource food be selected from the new resource food be selected from first milk basic protein, γ-aminobutyric acid,
Chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, CPP, avenabeta glucosan, Oligomeric manna sugar, stachyose, Rosa roxburghii, ferment
At least one of female beta glucan, newborn mineral salt, pueraria root powder, xylo-oligosaccharide；It is highly preferred that the new resource food is wood
Sugar, Oligomeric manna sugar and avenabeta glucosan.
Second object of the present invention is to provide a kind of preparation method of the postoperative tailored version clinical nutrition formula of above-mentioned children
Method, it comprises the following steps：
Step 1) prepares fat powder, liposoluble vitamin powder and water soluble vitamin powder using micro-capsule embedding techniques
End；
Step 2) prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water extraction, spray drying and sifting step；
Step 3) is smart by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals
China, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively, if desired
Above-mentioned raw materials can be carried out in advance baking processing；
Step 4) is by step 1) -3) sterilize after the powder for preparing is well mixed it is standby；
Mixed-powder in step 4) is prepared into nutrient powder, nutrition emulsion, capsule by step 5) according to conventional technical means
At least one of agent, tablet, pill or oral liquid；
Wherein, step 1) -3) order can mutually change.
Third object of the present invention is to provide a kind of production prepared by the postoperative tailored version clinical nutrition formula of above-mentioned children
Product, including nutrient powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..
In above-mentioned preparation method, wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, alcohol extracting concentration, water extraction are dense
Contracting, and concentrate is subjected to spray drying integration of drinking and medicinal herbs component powders are made；Wherein, the vitamin and fat are respectively by micro-
Encapsulated processing is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number
Raw material is crushed, and the raw material of crushing is placed in container, adds 3~5 times of 60~80% second that weight is raw material weight
Alcohol, soaked, extracted 2 times, merged alcohol extract and be concentrated into no alcohol taste；After the active compound dregs of a decoction fling to ethanol, weight is added as original
6~8 times of water of material weight is soaked, and is carried out 30~60min of decoction to soak, is filtered off except raw material, leaves and takes decoction
Liquid；Merge alcohol extract and decoction liquor after concentration, and it is spray-dried, it is same finally to prepare medicine food with 60~80 mesh sieves point
Derived components powder.
Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) using liposoluble vitamin as core
Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big
Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar
One or more in powder, emulsifying agent, stabilizer high-pressure homogeneous emulsification, are sprayed instantaneous dry, with 60~80 mesh sieves as wall material
Divide and prepare liposoluble vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, OK a karaoke club
Glue, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum
One or more works in powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer
For wall material, it is well mixed, sprays instantaneous dry, water soluble vitamin powder is prepared with 60~80 mesh sieves point.
Preferably, the specific implementation step of the fatty micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall material with
Water mixed dissolution prepares emulsion；After above-mentioned emulsion is stirred, emulsifying homogeneous processing is carried out, it is dry then to carry out spraying
Dry, screening prepares fat powder, and fat powder is compared with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all
Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester),
One in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin, monoglyceride, Tween 80
Kind is a variety of；The wall material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, fat egg
In vain, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean
One or more in fiber, lactose, candy sugar powder, emulsifying agent, stabilizer.
Fourth object of the present invention is to provide a kind of preparation method of the postoperative tailored version clinical nutrition formula of above-mentioned children,
It is wet processing, is comprised the following steps：
Step 1) prepare the protein containing predetermined weight number, fat, carbohydrate, dietary fiber, macroelement,
Trace element, vitamin, integration of drinking and medicinal herbs composition, the raw material of natural plants compound and new resource food, in scheduled volume
In water, according to the physical behavior of raw material, added successively according to sequencing, be stirred while addition, raw material is made
Mixed emulsion；
The temperature for the mixed emulsion that step 2) obtains step 1) is maintained at 40-50 DEG C, and adjustment homogenization pressure makes it all the time
It is maintained between 10-18Mpa, emulsifying homogeneous is carried out to mixed emulsion, then placed emulsion in evaporator, with default skill
Art parameter is concentrated, and is sterilized at 85-88 DEG C, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), is crossed 60~80 mesh sieves, is prepared into powder；Using upper
State powder and be prepared at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
Being used in the present invention, which includes orange peel, honeysuckle, dandelion, Poria cocos, matrimony vine, sealwort, arillus longan, the medicine of jujube, eats together
Derived components, wound healing, enhancing body immunity, the mitigation that postoperative patient can be effectively facilitated after mentioned component compatibility synergy are harmful
Or excessive inflammatory response, it can effectively improve the organism physiology, biochemistry and immunologic function of postoperative child patient.
Orange peel has conditioning digestive system, strengthens functions of intestines and stomach, and cholagogic is aid digestion, reduces, is digested not for insufficiency of the spleen diet
It is good, and nausea and vomiting etc..Orange peel can promote the secretion of digestive juice, exclude enteral pneumatosis.Intestines caused by anti-acetylcholine are received
Contracting.Also can intestinal tube spasmodic contraction caused by antagonism pilocarpinum and barium chloride.Shorten the Migrating Myoelectric Complex week of small intestine
Phase, improve the digestive function of small intestine.Active ingredient-aurantiamarin has excitation to stomach smooth muscle, can substantially antagonism Ah
Gastric emptying and small intestine push inhibitory action caused by tropine, adrenaline.Hesperidin methyl substantially Inhibition test stomach can burst
The generation of ulcer, and the effect of also anti-gastric acid secretion；Hesperidin methyl can make rat gallbladder contraction, solid in bile and bile
The excretion increase of material, uses VC and VK4 if merging, can strengthen cholagogic effect.
The active ingredient of honeysuckle mainly has organic acid, flavonoids, triterpene saponin, volatile oil and lot of trace member
Plain class, chlorogenic acid, isochlorogenic acid contained by it have resisting pathogenic microbes (bacterium, virus etc.) effect, can effectively prevented postoperative
The effect of infection；Heating has refrigeration function caused by honeysuckle induced by endotoxin, and accelerates endotoxin to be removed from blood, and it has anti-
Scorching, refrigeration function, suppresses inflammatory seep, inflammatory hyperplasia, and it can strengthen immune, improve the non-specific immune function of body.
Dandelion has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus, double to pneumonia
Coccus, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, proteus, shigella dysenteriae, typhoid bacillus etc. and micrococcus catarrhalis also have
Certain bactericidal action；Dandelion can significantly improve human peripheral lymphocyte blast transformation rate, Taraxacum Polysaccharides abdomen in vitro
Chamber injects the CDCC that can significantly increase mouse antibodies dependence macrophage..
Poria cocos energy clearing damp and promoting diuresis function of invigorating spleen, anticancer, antitumor action, it can also improve humoral immune function, its composition
Pachymaran physical efficiency strengthens the cytotoxic effect of T lymphocytes, that is, strengthens cell immune response, and therefore activate body pair
The immune surveillance system of tumour, it can also increase haemocyte generation.
Matrimony vine has enhancing nospecific immunity effect, and fructus lycii extracted solution has delaying senility function；Glycine betaine in matrimony vine
Hydrochloride can be such that the phosphatide in rat blood serum and liver substantially increases, to give for a long time the rat phosphatide caused by carbon tetrachloride decline and
Cholesterol rise has significant protective effect；LBP-X has repair to hepatic injury, and its mechanism may be by preventing
The damage of endoplasmic reticulum, promote protein synthesis and detoxication, recover the function of liver cell, and promote the regeneration of liver cell.
Sealwort has resisting pathogenic microbes effect, sealwort crude preparation and water Extract, to Grain-negative typhoid bacillus and leather
Blue positive staphylococcus aureus have inhibitory action, have inhibitory action to herpesviral；Sealwort methanolic extract can be significantly
To the blood glucose rise caused by antiadrenergic drug；Sealwort solution has the confrontation pituitrin induced Acute heart to rabbit vein injection
Myocardial ischemia acts on, and can significantly improve its hypoxia-bearing capability to mouse peritoneal injection；Sealwort has one to cellular immunity, humoral immunity
It is fixing to ring, lymphocyte transformation rate can be improved, is advantageous to the formation of antibody, it is horizontal to enhancing body health and anti-aging has
Definite meaning.
Longan extract to enhancing development, build up health beneficial, there is obvious anti-stress effect；Arillus longan carries
Take liquid to play the role of certain Green Tea Extract and improve cellular immune function；Arillus longan has obvious angst resistance effect.
Jujube has same immunosuppressive action with imuran, can suppress the production of antibody to atopic diseases
It is raw；Jujube alcohol extract may have inhibitory action to rat reactive antibody, and not produce inhibitory action to non-reacted antibody；Greatly
Flavones double glucosides A in jujube has calm, hypnosis and antihypertensive effect, and jujube plays the role of to increase cAMP in white blood cell.
Compared with prior art, the invention has the advantages that：
(1) various nutrients are supplemented general equilibrium of the present invention, while are added with strengthen immunity, reduced inflammation instead
The integration of drinking and medicinal herbs composition of the effect of wound healing, should be promoted, and effective effective substance is extracted using the method for water extraction alcohol extracting comprehensively,
While helping postoperative children physique to recover, the taste ability for improving children is played, it is improved and absorbs the energy of each nutriment
Power.
(2) present invention is a variety of excellent using lactalbumin, ocean fish collagen oligopeptide, soybean protein isolate, whole milk powder etc.
8 kinds of essential amino acids needed for children are supplemented matter protein general equilibrium, contribute to the formation and growth of postoperative tissue, are helped
Rehabilitation.
(3) present invention is matched science, is improved calcium using three kinds of calcium citrate, L-calcium lactate, newborn mineral salt high-quality calcium sources
Absorptivity and bioavailability, no constipation and gastrointestinal reaction.Calcium is the main component for forming children's bone and tooth, can be promoted
Enter upgrowth and development of children, improve bone density, promote union.
(4) present invention strengthens iron, the content of zinc.Iron be form hemoglobin important element, can pre- child-resistant it is postoperative
Hypoferric anemia；Zinc is one of the essential trace elements of the human body, is the constituent of a variety of enzymes, widely participates in various metabolism and lives
It is dynamic, be advantageous to the normal growth of skin, bone and tooth, promote children's appetite.
(5) present invention adds a variety of water-soluble type vitamin rational proportions, and B family vitamin can maintain dysregulated appetite, stomach and intestine
Wriggling and digestive juice secretion, promote digestive system health, promote wound healing；Present invention addition l-cn, l-cn tool
There is the function of mitigating nervous, strengthen immunity, accelerate protein synthesis, promote wound healing, protecting cell membrane stability.
(6) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to
Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques
Powdered oil so that powdered oil has preferable mobility, is easy to be well mixed with other powdered components；And use micro-capsule bag
After burying technology, grease is embedded in wall material, so as to avoid the contact with air to strengthen inoxidizability, is protected so as to play
The maximum effect of strong type grease.
(7) raw material of the postoperative tailored version clinical nutrition formula of children of the present invention is previously prepared in preparation process
Into 150~250 μm of powder, this make it that, when preparing finished product, each nutrition composition can be well mixed, in guarantor unit's volume
The content of each nutrition composition is essentially identical, while when preparing liquid type preparation, each nutrition composition can be fully dispersed and completely molten
Solution prevents occurring solid precipitation in liquid into solvent, the effect of finished product product has been effectively ensured.
The present invention is by the way that from rational basal nutrient element, using the proportioning of general equilibrium, while addition can effectively facilitate
The wound healing of postoperative patient, strengthen body immunity, mitigate harmful or excessive inflammatory response integration of drinking and medicinal herbs composition, natural plant
The specific nutrients such as compounds, new resource food, and adjust its proportioning and carry out compatibility synergy with basal nutrient element, give full play to
The effect of its component, so as to be effectively improved the organism physiology of postoperative child patient, biochemistry and immunologic function, reduce infectious concurrent
The incidence probability of disease, reduce overall expenses in hospital.
Embodiment
The present invention provides a kind of postoperative tailored version clinical nutrition formula of children, and it includes following component and its parts by weight：
15-22 parts protein, 9-13 parts fat, 40-55 parts carbohydrate, 7-10 parts dietary fiber, 0.7-1.2 parts macroelement,
0.01-0.04 parts trace element, 0.01-0.03 parts liposoluble vitamin, 0.1-0.2 parts water soluble vitamin, 0.05-4 part meals
Eat elite, 0.1-5 part integration of drinking and medicinal herbs composition, 0.1-3 part natural plants compounds and 0.005-2 part new resource foods.This is matched somebody with somebody
Fang Zhong, protein, fat, the productivity ratio of carbohydrate are 17：29：54；The dietary fiber includes 6-8 parts water solubility
Dietary fiber and 1-2 part insoluble diedairy fibers.
With reference to embodiment, the embodiment of the present invention is further described.Following examples are only used for more
Add and clearly demonstrate technical scheme, and can not be limited the scope of the invention with this.
Embodiment 1
The postoperative tailored version clinical nutrition formula of children of the present invention includes PURE WHEY 10g, soybean protein isolate
5.33g, whole milk powder 10.8g, bovine colostrum 0.33g, hydrolysis Isin glue collagen 0.33g, ocean fish oligopeptide 0.2g, taurine
0.12g；Olive oil 2.59g, soybean oil 4.2g, coconut oil 2.59g, perilla herb oil 0.6g, medium chain triglyceride 0.2g；Maltodextrin
31.7g, rock sugar 6.67g；Water-soluble dietary fiber 7.01g, soybean fiber 1.07g；Calcium 0.37g in macroelement, phosphorus 0.234g,
Potassium 0.093g, sodium 0.243g, magnesium 0.149g；Iron 0.011g, zinc 0.008g in trace element；Vitamin A 00.0005g, β-Hu Luo
Bu Su 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, vitamin B20.001g, dimension
Raw plain B60.001g, vitamin B120.0000017g, vitamin C 0.134g, pantothenic acid 0.003g, folic acid 0.00013g, nicotinic acid
0.0124g；Oatmeal 0.67g, buckwheat 0.67g, white radish powder 0.67g, white fungus powder 0.33g, powdered beef 0.33g, Poria cocos
0.33g, matrimony vine 0.33g, sealwort 0.33g, dandelion 0.33g, jujube 0.33g, arillus longan 0.33g, orange peel 0.33g, honeysuckle
0.33g, stachyose 0.33g, Oligomeric manna sugar 0.33g, avenabeta glucosan 0.33g, l-cn 0.67g.
Embodiment 2
The postoperative tailored version clinical nutrition formula of children of the present invention includes PURE WHEY 5g, soybean protein isolate
10.33g, whole milk powder 10.8g, bovine colostrum 0.33g, hydrolysis Isin glue collagen 0.03g, ocean fish oligopeptide 0.01g, ox sulphur
Sour 0.12g；Olive oil 2.59g, soybean oil 4.2g, coconut oil 2.59g, perilla herb oil 0.6g, medium chain triglyceride 0.2g；Malt
Dextrin 31.7g, rock sugar 6.67g；Water-soluble dietary fiber 7.01g, soybean fiber 1.07g；Calcium 0.37g, phosphorus in macroelement
0.234g, potassium 0.093g, sodium 0.243g, magnesium 0.149g；Iron 0.011g, zinc 0.008g in trace element；Vitamin
A00.0005g, beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension
Raw plain B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.134g, pantothenic acid 0.003g,
Folic acid 0.00013g, nicotinic acid 0.0124g；Oatmeal 0.67g, buckwheat 0.67g, white radish powder 0.67g, white fungus powder 0.33g, ox
Digested tankage 0.33g, Poria cocos 0.33g, matrimony vine 0.33g, sealwort 0.33g, dandelion 0.33g, jujube 0.33g, arillus longan 0.33g, tangerine
Skin 0.33g, honeysuckle 0.33g, stachyose 0.33g, Oligomeric manna sugar 0.33g, avenabeta glucosan 0.33g, l-cn
0.67g。
Embodiment 3
The postoperative tailored version clinical nutrition formula of children of the present invention includes PURE WHEY 5g, soybean protein isolate
10.33g, whole milk powder 10.8g, bovine colostrum 0.33g, hydrolysis Isin glue collagen 0.03g, ocean fish oligopeptide 0.01g, ox sulphur
Sour 0.12g；Olive oil 2.59g, soybean oil 4.2g, coconut oil 2.59g, perilla herb oil 0.6g, medium chain triglyceride 0.2g；Malt
Dextrin 31.7g, rock sugar 6.67g；Water-soluble dietary fiber 7.01g, soybean fiber 1.07g；Calcium 0.37g, phosphorus in macroelement
0.234g, potassium 0.093g, sodium 0.243g, magnesium 0.149g；Iron 0.011g, zinc 0.008g in trace element；Vitamin
A00.0005g, beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, dimension
Raw plain B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.134g, pantothenic acid 0.003g,
Folic acid 0.00013g, nicotinic acid 0.0124g；Oatmeal 0.67g, buckwheat 0.67g, white radish powder 0.67g, white fungus powder 0.33g, ox
Digested tankage 0.33g, Poria cocos 0.03g, matrimony vine 0.03g, sealwort 0.03g, dandelion 0.03g, jujube 0.03g, arillus longan 0.03g, tangerine
Skin 0.03g, honeysuckle 0.03g, stachyose 0.03g, Oligomeric manna sugar 0.03g, avenabeta glucosan 0.33g, l-cn
0.67g。
Embodiment 4
A kind of preparation method of the postoperative special clinical nutrition formula of children as described in 1~embodiment of embodiment 3 is as follows：
1) powdered oil (powder fat) is prepared：
A) the wall material aqueous solution is prepared：Take 8 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, dietary fiber 2
Gram (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, Arabic gum
0.2 gram, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stirs and (has ready conditions and heat while stirring to 60 DEG C, kept for 30 points
Room temperature is cooled to after clock).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 9.56 milliliters of greases monoglyceride
2.43 milliliters, 3.94 milliliters of soybean oil, 2.43 milliliters of coconut oil, 0.56 milliliter of perilla herb oil, 0.19 milliliter of medium chain triglyceride).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added
It is sufficiently mixed.
E) after addition stabilizer agar takes 0.1 gram (total solid concentration is 0.2%) to enter mixed solution, it is settled to water
200 milliliters (total solid concentration be 25%), disperse 2 minutes at a high speed under 20000r/min.
F) homogenization pressure is 25MPa, homogeneous 3 times (every time 5 minutes), homogeneous emulsion is made.
G) obtained emulsion is spray-dried, EAT is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder
Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed
Raw material be placed in container, the raw material of predetermined weight number is crushed using pulverizer, the raw material of crushing is placed in container
In, 3~5 times of 60~80% ethanol that weight is raw material weight are added, is soaked, extracted 2 times, merges alcohol extract and concentrates
To without alcohol taste；After the active compound dregs of a decoction fling to ethanol, add weight and soaked for 6~8 times of water of raw material weight, soak is entered
Row decocts 30~60min, filters off except raw material, leaves and takes decoction liquor；Merge alcohol extract and decoction liquor after concentration, and it is carried out
Spray drying, finally prepare integration of drinking and medicinal herbs component powders with 60~80 mesh sieves point；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from oligomeric different malt
Sugar is used as wall material, carries out 2 emulsifying homogeneous processing under high pressure, the emulsifying homogeneous time is 10~15min, then carries out spraying wink
When dry, point prepare liposoluble vitamin powder with 60~80 mesh sieves；Using the water soluble vitamin of predetermined weight number as core
Material, from maltodextrin, oligoisomaltose as wall material, it is well mixed, sprays instantaneous dry, prepared with 60~80 mesh sieves point
Water soluble vitamin powder；
4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite,
Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；(step 1) -4) order
Can mutually it change)
5) by step 1) -4) prepare powder in the similar devices such as mixer be well mixed after sterilize it is standby；
6) mixed-powder obtained by step 5) is prepared into nutrient powder, nutrition emulsion, capsule according to conventional technical means
At least one of agent, tablet, pill or oral liquid.
In step 6), optionally increase appropriate food thickening agent, food additives and related formulation auxiliary material.
The food thickening agent is in guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum
At least one, the food additives are Aspartame, flavoring essence spices, at least one of brown sugar；More preferably OK a karaoke club
Glue, Arabic gum, guar gum, Aspartame, flavoring essence spices.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing
The danger of green powder blast.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 5
1) influence of nutrient formulation preparation prepared by the present invention to normal mouse；
First, acute toxicity test；
The nutrient powder prepared with the embodiment of the present invention 2,1 group of little Bai is given with 150 times of clinical consumption per day and 200 times respectively
Mouse feeding is offerd medicine, and is observed 14；As a result all small white mouses are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no
Toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other adverse reactions.
2nd, long term toxicity test；
Nutrition powder prepared by the embodiment of the present invention 1 is dissolved in water to mouse by 3,10 and 24g nutrient powders/kg, to 3
Group mouse difference continuous use 12 weeks, 2 times a day, and after drug withdrawal 4 weeks, the results showed that：Chinese medicine of the present invention is to two groups of test mices
Hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood glucose, the index such as blood fat have no significant effect, it is dirty
Device naked eyes are without finding that difference change and histological indications show, after medication 12 weeks and drug withdrawal 4 weeks, the equal nothing of Organs of Mice
It is obvious to change.Illustrate that nutrient formulation preparation of the present invention to small toxicity after mouse long-term prescription, does not have abnormal reaction yet, answered after drug withdrawal
With safety.
2) the anti-infective experiment of clinical nutrition formula of the present invention；
This anti-infective experiment is carried out for blank group, control group with the nutrient powder prepared according to embodiment 1~3.
Kunming mice 200 is taken respectively, male and female half and half, is randomly divided into 10 groups, every group 20, is carried out staphylococcus aureus
(CMCC26112), the dead Protection of the infection induced mice of beta hemolytic streptococcus (CMCC32210).Embodiment 1~
3 groups of embodiment is according to dosage 1000mg/kg/day gavages, blank group isometric physiological saline gavage, control group 0.4g/kg
Amoxicillin gavage.After continuous 3d, different strains are injected intraperitoneally in the 4th day, according to minimum lethal dose (MLD) in each group.Press
According to preceding dose, it is further continued for giving each group mouse stomach 3d.The death toll of each group mouse in 7d after infecting is observed and recorded, is calculated dead
Rate.
Respectively protective effect of the formula to the death of infection of staphylococcus aureus induced mice of table 1
Experiment shows 3 groups of 1~embodiment of embodiment to small caused by staphylococcus aureus, beta hemolytic streptococcus infection
Mouse death has different degrees of protective effect.Blank group is contrasted, 1~3 group of embodiment is dead to all strain infection induced mices
Rate reduces by more than 30%.
From above-described embodiment, various components mutually match in the postoperative special clinical nutrition formula of children of the present invention
Close, provide reasonable, comprehensive nutritional support for postoperative puerilism patient, to improve the condition of postoperative child patient, simultaneously
Addition with add it is anti-infective, enhancing immunologic function integration of drinking and medicinal herbs composition, be effectively improved postoperative child patient organism physiology,
Biochemical and immunologic function, the incidence probability of infection complication is reduced, promote patient's rehabilitation as early as possible.
The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit
In particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and to replace
In generation, is also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and repair
Change, all should be contained within the scope of the invention.
Claims (10)
1. a kind of postoperative tailored version clinical nutrition formula of children, it is characterised in that including following component and its parts by weight：15-
22 parts of protein, 9-13 parts fat, 40-55 parts carbohydrate, 7-10 parts dietary fiber, 0.7-1.2 parts macroelement,
0.01-0.04 parts trace element, 0.01-0.03 parts liposoluble vitamin, 0.1-0.2 parts water soluble vitamin, 0.05-4 part meals
Eat elite, 0.1-5 part integration of drinking and medicinal herbs composition, 0.1-3 part natural plants compounds and 0.005-2 part new resource foods；
Wherein, the integration of drinking and medicinal herbs composition is selected from Poria cocos, orange peel, honeysuckle, dandelion, Poria cocos, matrimony vine, sealwort, arillus longan, big
At least one of jujube；
Wherein, the new resource food be selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones,
CPP, avenabeta glucosan, Oligomeric manna sugar, stachyose, Rosa roxburghii, yeast beta-dextran, newborn mineral salt, maca
At least one of powder, xylo-oligosaccharide.
A kind of 2. postoperative tailored version clinical nutrition formula of children according to claim 1, it is characterised in that the clinical battalion
Support in formula, protein：Fat：The productivity ratio of carbohydrate is 15~20：25~30：50~60.
3. the postoperative tailored version clinical nutrition formula of a kind of children according to claim 1, it is characterised in that the meals are fine
Dimension includes 6-8 parts water-soluble dietary fiber and 1-2 part insoluble diedairy fibers.
4. the postoperative tailored version clinical nutrition formula of a kind of children according to claim 1, it is characterised in that the medicine food is same
Derived components are orange peel, honeysuckle, dandelion, Poria cocos, matrimony vine, sealwort, arillus longan, jujube.
5. the postoperative tailored version clinical nutrition formula of a kind of children according to claim 4, it is characterised in that the medicine food is same
The parts by weight of derived components are as follows：0~1 part of orange peel, 0~1 part of honeysuckle, 0~1 part of dandelion, 0~1 part of Poria cocos, matrimony vine 0~1
Part, 0~1 part of sealwort, 0~1 part of arillus longan, 0~1 part of jujube.
A kind of 6. postoperative tailored version clinical nutrition formula of children according to claim 1, it is characterised in that the new resources
Food is stachyose, Oligomeric manna sugar and avenabeta glucosan.
A kind of 7. postoperative tailored version clinical nutrition formula of children according to claim 1, it is characterised in that the natural plant
Compounds are selected from l-cn, Glucosamine, FOS, lutein, phytosterol, lycopene, resveratrol, big
At least one of allicin.
A kind of 8. postoperative tailored version clinical nutrition formula of children according to claim 1, it is characterised in that the meals essence
China in cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fish and shrimp, poultry meat, fruits at least
It is a kind of.
A kind of 9. preparation method of the postoperative tailored version clinical nutrition formula of children as claimed in claim 1, it is characterised in that bag
Include following steps：
The fat, liposoluble vitamin, water soluble vitamin of step (1) predetermined weight are respectively adopted micro-capsule embedding techniques and prepared simultaneously
Cross 60~80 mesh sieves and powder is made；
The integration of drinking and medicinal herbs composition of step (2) predetermined weight is made up of crushing, alcohol extracting, water extraction, spray drying and 60-80 mesh sieves excessively
Powder；
Remaining component of step (3) predetermined weight is prepared into the powder that particle diameter is 150~250 μm respectively；
The powder that step (4) prepares step (1)~(3) is sterilized standby after being well mixed；
Direct-edible pharmaceutical formulation is made in step (4) mixed powder by step (5)；
Wherein, the order of step (1)~(3) can be changed mutually；The pharmaceutical formulation include nutrient powder, nutrition emulsion, capsule,
Tablet, pill, oral liquid.
10. the preparation method of the postoperative tailored version clinical nutrition formula of children according to claim 1, it is characterised in that bag
Include following steps：
Step 1) prepares the protein containing predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, micro
Element, vitamin, integration of drinking and medicinal herbs composition, the raw material powder of natural plants compound and new resource food, in scheduled volume
In water, according to the physical behavior of raw material, added successively according to sequencing, be stirred while addition, raw material is made
Mixed emulsion；
The mixed emulsion that step 2) obtains step 1) carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), sieving, is prepared into powder, and above-mentioned powder is prepared into
At least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
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