CN1075727C - Shentong capsule and preparing method thereof - Google Patents

Abstract

The present invention relates to a Shentong capsule and a processing method thereof. The capsule is prepared from 70 to 90g of astragalus root, 30 to 50g of ginseng, 30 to 50g of ganoderma, 15 to 40g of cordyceps, 70 to 90g of earthworm, 30 to 50g of chuanxiong rhizome, 30 to 50g of Chinese angelica, 70 to 90g of caulis spatholobi, 30 to 50g of safflower, 30 to 50g of achyranthes root, 30 to 50g of peach kernel, 30 to 50g of red peony root, 30 to 50g of cassia twig, 30 to 50g of myrrh and 70 to 90g of red sage root. The ginseng, the cordyceps, the earthworm, the chuanxiong rhizome, the Chinese angelica and the cassia twig are mixed into fine powder according to a formulation. In the formulation, other eight kinds of medicine are crushed and are decocted by two time by adding water. A filtered liquid is combined and is concentrated into extractum. The extractum is mixed with the fine powder, is dried, is crushed, is screened and is respectively capsulized into a Shentong capsule. A clinical total effective rate reaches 89.15%.

Description

The capsule and the production method thereof of treatment peripheral neuropathy

The present invention is a kind of medicine that belongs to the peripheral neuropathy that treatment causes by diabetes.

Because the peripheral neuropathy that diabetes cause is one of most common complication, its clinical manifestation was for previously once suffering from diabetes, lateral symmetry distal type paraesthesia appears in the recent period, numbness is with the acupuncture sample and burn the sample paraesthesia, meets cold and increases the weight of, and the extremity tendon reflex goes down or disappears, nerve conduction velocity also has phenomenons such as obvious change, and modern medicine does not have more suitable Therapeutic Method as yet, only is symptomatic treatment, and curative effect is not remarkable.

The objective of the invention is to propose a kind of capsule (its commodity are called magic capsule) and production method for the treatment of peripheral neuropathy, adopt the drug development of pure natural plant to form, can effectively treat the medicine of the peripheral neuropathy that causes by diabetes.

The present invention adopts pure natural plant, through being processed into magic capsule.It is characterized in that: this capsule is made up of the Radix Astragali, Radix Ginseng, Ganoderma, Cordyceps, Pheretima, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Caulis Spatholobi, Flos Carthami, Radix Achyranthis Bidentatae, Semen Persicae, Radix Paeoniae Rubra, Ramulus Cinnamomi, Myrrha, Radix Salviae Miltiorrhizae, and its thousand recipe ratios are: Radix Astragali 70-90g, Radix Ginseng 30-50g, Ganoderma 30-50g, Cordyceps 15-40g, Pheretima 70-90g, Rhizoma Chuanxiong 30-50g, Radix Angelicae Sinensis 30-50g, Caulis Spatholobi 70-90g, Flos Carthami 30-50g, Radix Achyranthis Bidentatae 30-50g, Semen Persicae 30-50g, Radix Paeoniae Rubra 30-50g, Ramulus Cinnamomi 30-50g, Myrrha 30-50g, Radix Salviae Miltiorrhizae 70-90g; Its production method: give as one thinks fit cataclasm by the recipe ratio taking-up Radix Astragali, Ganoderma, Caulis Spatholobi, Flos Carthami, Semen Persicae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Myrrha, add 1-15 times of water gaging and mix decoction, extract secondary, each 1-3 hour, gradation is filtered, merging filtrate is condensed into the extractum of relative density 1.10-1.40, and temperature is at 80-90 ℃; Radix Ginseng, Cordyceps, Pheretima, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi mixed powder are broken into fine powder, mix with extractum, dry below 80 ℃, dry thing is ground into fine powder, crosses the 70-90 mesh sieve, divides the capsule of packing into.

The pharmacology of each medicine component of the present invention:

The Radix Astragali, Radix Ginseng are monarch drug, and this controls it.Wherein Radix Ginseng sweet in the mouth strongly invigorating primordial QI is just put down in writing " tonifying five ZANG-organs is pacified spirit, decides soul, and spasmolytic is throbbed with fear, and removes pathogen, makes eye bright, happy Fructus Alpiniae Oxyphyllae " as far back as Shennong's Herbal.Radix Astragali slightly warm in nature tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, " pearl sac " are sayed it, and " mend all empty deficiencies, one also; Benefit vigour, two also; Strong taste, three also ".Two medicines mutually and think monarch can make the vigour multiplication, promote the blood vessels operation with the meridian dredging.

Pheretima, Caulis Spatholobi, when being classified as ministerial drug, the performance major function.Wherein the Pheretima nature and flavor are salty-cold, and the heat clearing away suppressing the hyperactive liver is longer than the effect of the meridian dredging, can get through passages through which vital energy circulates under the promotion of gas.Caulis Spatholobi property bitter but sweet flavor has that promoting the circulation of blood is enriched blood, relaxing muscles and tendons and activating QI and blood in the collateral, and supplementary Amplifications of the Compendium of Materia Medica is sayed its " invigorate blood circulation most, a little less than the punish-old people asthenia of qi and blood, diseases such as numb hand and foot paralysis "; " decoction pieces is newly joined " then cloud its can " blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates ".The ministerial drug benefiting blood and regulating blood circulation is better when being classified as, and Jing-Yue Complete Works is said: " Radix Angelicae Sinensis, its sweet in the mouth and weighing is so can enrich blood; Its gas is light and hot, so again can promoting the circulation of blood.Invigorating middle warmer has, in the row benefit is arranged, and subtracts the gas medicine in the blood, and also the panacea in the blood also ".This three and monarch drug are compatible, QI and blood mutually and, the prosperous blood of gas is capable.

Help again in the prescription with Rhizoma Chuanxiong, Myrrha, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra, the medicine that this is all the blood circulation promoting and blood stasis dispelling the meridian dredging more increases monarch, ministerial drug effect.Wherein Rhizoma Chuanxiong gas is apt to away scurry, but blood-activating and qi-promoting, and depletion of YIN coagulates the attitude of viscous again; The Myrrha analgesic therapy of invigorating blood circulation; Radix Salviae Miltiorrhizae can be invigorated blood circulation, removing heat from blood, regulating menstruation, tonneau GUAN-pulse; The Flos Carthami blood circulation promoting and blood stasis dispelling, pain relieving is stimulated the menstrual flow; The Semen Persicae blood circulation promoting and blood stasis dispelling; Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow can help the twelve regular channels; But Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain.All medicines is played the merit of blood circulation promoting and blood stasis dispelling the meridian dredging mutually and altogether, with inrigorating qi and promoting blood circulation medicine mutually 5, and capable, the stasis of blood of the prosperous blood of the gas ruton of dispelling then.

Help again in the prescription with Ganoderma lucidum seu Japonicum, Cordyceps to help group power of medicine training benefit.The Ganoderma lucidum seu Japonicum sweet in the mouth is flat, energy nourishing heart-disney, strong muscles and bones.Shennong's Herbal claims its " god is protected, beneficial vital essence, hard muscles and bones in sharp joint ".Cordyceps also sweet in the mouth is flat, but kidney-reinforcing Yang-strengthening." property of medicine is examined " claims " secret lean gas is specially mended the gate of vitality ".The two uses the deficiency that helps to train the reinforcing the heart kidney together.

Be messenger drug with Ramulus Cinnamomi in the prescription, its acrid-sweet flavor, warm in nature is good at promoting the flow of QI-blood by warming the meridian.Say Ramulus Cinnamomi " can lead medicine to sore spot, the expectorant blood coagulation stagnates between podomere to remove " in " medicine justice ".But the property that while ministerial drug Pheretima tool is walked to scurry also priming is returned through playing the effect of messenger drug.

Magic capsule has carried out pharmacodynamic experiment research by Chinese medicine research department of Heilongjiang University of Chinese Medicine, and result of study shows that magic capsule can obviously reduce the intracellular sorbitol content of diabetic sciatic nerve, improves Na ⁺-K ⁺-ATP enzyme activity, and slight hypoglycemic activity is arranged.

In order to prove clinical drug safety, magic capsule has carried out acute toxicity test and long term toxicity test by Chinese medicine research department of Heilongjiang University of Chinese Medicine, and result of the test shows:

1, the heavy dose of 4.8g capsule 's content of per day for adults dosage calculates, and the mice dosage be its 390.6 times, does not see dead and the untoward reaction generation, so think the oral safety non-toxic of this medicine.

2, the oral magic capsule of rat is after 60 days, general situation, every indexs such as growth promoter, routine blood test, liver, renal function there is no ANOMALOUS VARIATIONS, the more every index of high and low dose group and matched group does not all have significant difference, histopathologic examination also no abnormality seen changes, prove that this medicine takes safe and reliablely, have no side effect.

The present invention through observation on Clinical Application, has following advantage compared with prior art:

1, magic capsule is the active drug of treatment blood-vessel obstructive, deficiency of both the liver and kidney type diabetic peripheral neuropathy, and total effective rate is 89.15%.

2, magic capsule improves significantly to patient's sings and symptoms, and the recovery to nerve conduction velocity and tendon reflex simultaneously also has tangible effect, can illustrate that magic capsule is an ideal treatment diabetic peripheral neuropathy medicine.

3, find except that improving primary symptom blood glucose is also had certain control action in treatment, the Rhizoma Gastrodiae Pilulae group does not then have.Illustrate that this medicine has better action aspect treating both the principal and secondary aspects of a disease.

4, magic capsule is not found any toxicity, side effect in clinical practice; Liver, renal function are had no effect, and not seeing on inspection has ANOMALOUS VARIATIONS.

Embodiments of the invention:

Magic capsule, by the Radix Astragali, Radix Ginseng, Ganoderma, Cordyceps, Pheretima, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Caulis Spatholobi, Flos Carthami, Radix Achyranthis Bidentatae, Semen Persicae, Radix Paeoniae Rubra, Ramulus Cinnamomi, Myrrha, Radix Salviae Miltiorrhizae, by filling a prescription thousand: Radix Astragali 70-90g, Radix Ginseng 30-50g, Ganoderma 30-50g, Cordyceps 15-40g, Pheretima 70-90g, Rhizoma Chuanxiong 30-50g, Radix Angelicae Sinensis 30-50g, Caulis Spatholobi 70-90g, Flos Carthami 30-50g, Radix Achyranthis Bidentatae 30-50g, Semen Persicae 30-50g, Radix Paeoniae Rubra 30-50g, Ramulus Cinnamomi 30-50g, Myrrha 30-50g, Radix Salviae Miltiorrhizae 70-90g form through steaming and decocting, extractum, drying, pulverizing, packing.

Embodiment 1: get by prescription: Radix Astragali 70g, Radix Ginseng 30g, Ganoderma 30g, Cordyceps 15g, Pheretima 70g, Rhizoma Chuanxiong 30g, Radix Angelicae Sinensis 30g, Caulis Spatholobi 70g, Flos Carthami 30g, Radix Achyranthis Bidentatae 30g, Semen Persicae 30g, Radix Paeoniae Rubra 30g, Radix Salviae Miltiorrhizae 70g, Ramulus Cinnamomi 30g, Myrrha 30g.Giving of the Radix Astragali in the above-mentioned prescription, Ganoderma, Caulis Spatholobi, Flos Carthami, Radix Achyranthis Bidentatae, Semen Persicae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Myrrha is cataclasm, add 10 times of water gagings and mix decoction extraction secondary, each 2.5 hours, gradation was filtered, and filtrate is condensed into the extractum (80 ℃ of heat are surveyed) of relative density 1.35, Radix Ginseng, Cordyceps, Pheretima, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi mixed powder are broken into fine powder, mix with extractum, 70 ℃ dry down, and dry thing is ground into fine powder, cross 80 mesh sieves, divide in 1000 capsules of packing into.

Embodiment 2: get by prescription: Radix Astragali 80g, Radix Ginseng 40g, Cordyceps 40g, Pheretima 80g, Rhizoma Chuanxiong 40g, Radix Angelicae Sinensis 40g, Caulis Spatholobi 80g, Flos Carthami 40g, Radix Achyranthis Bidentatae 40g, Semen Persicae 40g, Radix Paeoniae Rubra 40g, Ramulus Cinnamomi 40g, Myrrha 40g, Radix Salviae Miltiorrhizae 80g.Give as one thinks fit the Radix Astragali in the above-mentioned prescription, Ganoderma, Caulis Spatholobi, Flos Carthami, Radix Achyranthis Bidentatae, Semen Persicae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Myrrha cataclasm, add 10 times of water gagings and mix decoction, extract secondary, each 2.5 hours, gradation is filtered, filtrate is condensed into the extractum (80 ℃ of heat are surveyed) of relative density 1.35, and Radix Ginseng, Cordyceps, Pheretima, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi mixed powder are broken into fine powder, mix with cream, dry below 70 ℃, dry thing is ground into fine powder, crosses 80 mesh sieves, divides in 1000 capsules of packing into.

Claims (2)

1, the capsule of treatment peripheral neuropathy, it is characterized in that: per thousand is to make with the raw material of following consumption: Radix Astragali 70-90g, Radix Ginseng 30-50g, Ganoderma 30-50g, Cordyceps 15-40g, Pheretima 70-90g, Rhizoma Chuanxiong 30-50g, Radix Angelicae Sinensis 30-50g, Caulis Spatholobi 70-90g, Flos Carthami 30-50g, Radix Achyranthis Bidentatae 30-50g, Semen Persicae 30-50g, Radix Paeoniae Rubra 30-50g, Ramulus Cinnamomi 30-50g, Myrrha 30-50g, Radix Salviae Miltiorrhizae 70-90g.

2, the capsular production method of treatment peripheral neuropathy as claimed in claim 1, it is characterized in that: take out the Radix Astragali, Ganoderma, Caulis Spatholobi, Flos Carthami, Semen Persicae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Myrrha is cataclasm, add 1-15 times of water gaging and mix decoction, extract secondary, each 1-3 hour, gradation was filtered, merging filtrate, be condensed into the extractum of relative density 1.10-1.40, temperature is surveyed 80-90 ℃ of heat; Radix Ginseng, Cordyceps, Pheretima, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ramulus Cinnamomi mixed powder are broken into fine powder, mix with extractum, dry below 80 ℃, dry thing is ground into fine powder, crosses the 70-90 mesh sieve, divides the capsule of packing into.