CN107536822A - A kind of erythromycin enteric preparation - Google Patents
A kind of erythromycin enteric preparation Download PDFInfo
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- CN107536822A CN107536822A CN201610492112.2A CN201610492112A CN107536822A CN 107536822 A CN107536822 A CN 107536822A CN 201610492112 A CN201610492112 A CN 201610492112A CN 107536822 A CN107536822 A CN 107536822A
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- erythromycin
- enteric
- substrate
- tween
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title claims abstract description 136
- 229960003276 erythromycin Drugs 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000758 substrate Substances 0.000 claims abstract description 36
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims abstract description 30
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 30
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 28
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000002702 enteric coating Substances 0.000 claims abstract description 24
- 238000009505 enteric coating Methods 0.000 claims abstract description 24
- 229920002472 Starch Polymers 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 235000019698 starch Nutrition 0.000 claims abstract description 20
- 239000008107 starch Substances 0.000 claims abstract description 20
- 239000004359 castor oil Substances 0.000 claims abstract description 15
- 235000019438 castor oil Nutrition 0.000 claims abstract description 15
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 15
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 15
- 239000004925 Acrylic resin Substances 0.000 claims abstract description 11
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 11
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 11
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 11
- 239000011248 coating agent Substances 0.000 claims description 12
- 238000000576 coating method Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 239000000084 colloidal system Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 230000002572 peristaltic effect Effects 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 239000007884 disintegrant Substances 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 4
- 210000000936 intestine Anatomy 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims 1
- 230000000857 drug effect Effects 0.000 abstract description 3
- 239000003242 anti bacterial agent Substances 0.000 abstract description 2
- 229940088710 antibiotic agent Drugs 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 description 9
- 229920002125 Sokalan® Polymers 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- -1 hydroxyl Propyl Chemical group 0.000 description 4
- 239000004584 polyacrylic acid Substances 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 238000000227 grinding Methods 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A kind of erythromycin enteric preparation, belongs to antibiotics, is made up of substrate and enteric coating two parts, substrate composition weight number meter：Erythromycin：12.5 parts, starch：2.5~3.0 parts, Tween 80：0.21~0.25 part, hydroxypropyl cellulose：1~1.5 part, magnesium stearate：0.3~0.5 part, talcum powder：0.8~1.5 part；Enteric coating composition weight number meter：Polyacrylic resin (II)：0.81~0.84 part, ethanol：15~16 parts, Tween 80：0.16~0.2 part, diethyl phthalate：0.16~0.2 part, castor oil：0.48~0.6 part, talcum powder：0.59~0.7 part.Using the substrate of the present invention, enteric coating formula made from erythromycin enteric-coated tabletses average release >=90% in drug effect, far above NF standard, and discharge steady, drug effect is higher than NF standard before the deadline；Outward appearance upper surface exquisiteness is glossy, long time stored not influence effectiveness.
Description
Technical field
The invention belongs to antibiotics formulation art, and in particular to a kind of erythromycin enteric-coated tabletses and preparation method thereof.
Background technology
Dissolution rate refers to medicine from the speed and degree of the dissolution in regulation solvent of the solid pharmaceutical preparations such as tablet.Dissolution rate is piece
One important indicator of agent quality control, the inspection of dissolution rate typically should all be made to the medicine of slightly solubility.Erythromycin is conventional anti-
Raw plain medicine, anti-microbial property is similar with penicillin, and the bacterial strain of drug resistance is produced to penicillin typically to erythromycin-sensitive.In order to tie up
Protect erythromycin drug effect and in order to avoid the stimulation to stomach, be prepared into erythromycin enteric-coated tabletses so that patient takes.2015 editions pharmacopeia rule
Determine erythromycin enteric-coated tabletses dissolution rate limit >=80%.For a long time, the dissolution rates of erythromycin enteric-coated tabletses how is controlled to reach state
Family's standards of pharmacopoeia, so as to produce the product for meeting patient requests, perplexs numerous similar drug manufacturers always.So seek
Asking a kind of stimulates erythromycin enteric-coated tabletses small, that release is high, stability is good to show important especially stomach.
The content of the invention
The technical problem to be solved in the present invention is：The problem of overcoming prior art to exist, there is provided a kind of erythromycin release is flat
Surely, dissolution rate is all higher than 90%, and the change of its dissolution rate is little after long-term storage, the erythromycin enteric-coated tabletses of efficacy stability；It is and raw
Production. art step is few, flow is simple, the preparation method of easily operated erythromycin enteric-coated tabletses.
The technical solution adopted for the present invention to solve the technical problems is：This kind of erythromycin enteric preparation, by substrate and intestines
Molten clothing two parts composition, it is characterised in that：
Substrate composition weight number meter：Erythromycin：12.5 parts, starch：2.5~3.0 parts, Tween-80：0.21~0.25 part, hydroxyl
Propyl cellulose：1~1.5 part, magnesium stearate：0.3~0.5 part, talcum powder：0.8~1.5 part；Enteric coating composition weight number
Meter：Polyacrylic resin (II)：0.81~0.84 part, ethanol：15~16 parts, Tween-80：0.16~0.2 part, phthalic acid
Diethylester：0.16~0.2 part, castor oil：0.48~0.6 part, talcum powder：0.59~0.7 part.
The specific enteric coated preparations prescription each component parts by weight are calculated as：Substrate component includes：Erythromycin：12.5 parts, form sediment
Powder：2.7 parts, Tween-80：0.23 part, hydroxypropyl cellulose：1.2 part, magnesium stearate：0.4 part, talcum powder：1.1 part；Enteric coating
Composition weight number meter：Polyacrylic resin (II)：0.82 part, the ethanol of concentration more than 90%：15 parts, Tween-80：0.17
Part, diethyl phthalate：0.18 part, castor oil：0.54 part, talcum powder：0.62 part.
A kind of preparation method of erythromycin enteric preparation, making step are as follows：
The making of described enteric coating comprises the following steps：
Will according to the desired amount of polyacrylic resin of aforementioned formula (II), Tween-80, diethyl phthalate, castor oil and
Talcum powder mixes, and adds the ethanol dissolving of concentration more than 90%, is put into mixed grinding one time in colloid mill after dissolving, cross 100~
300 mesh sieves, the blending ingredients of excessively complete sieve are transferred to agitator tank, stirred by peristaltic pump, it is standby after stirring.
The making of described substrate comprises the following steps：
After a crushes three kinds of erythromycin powder, starch and hydroxypropyl cellulose raw materials, sieved respectively now 80~100, three
Uniformly after mixing, add adhesive and disintegrant is well mixed, be then transferred to 10~15min of granulation in granulator, obtain wet
Grain；
Wet granular is dried b in ebullated dryer, 50~60 DEG C of temperature control, make its water content be maintained at 5%~
6%, particle then is arranged with wire netting, arranges to finish and adds lubricant and further mix, afterwards with tabletting machine, obtains base
Piece；
Above-mentioned gained erythromycin substrate is placed in seed-coating machine, starts seed-coating machine, deployed intestines will be formulated by foregoing enteric coating
Molten clothing liquid is equably sprayed on substrate surface by spray gun and obtains finished product erythromycin enteric-coated tabletses.
Described adhesive is 13~13.5% starch slurry, and its addition is 10~13kg.
Described disintegrant refers to Tween-80, and addition is every 100,000 0.21~0.25kg.
Described lubricant refers to magnesium stearate and talcum powder.
Compared with existing erythromycin enteric-coated tabletses and preparation method thereof, the invention has the advantages that：
1st, erythromycin enteric-coated tabletses appearance according to gained of the invention is fine and smooth, smooth, smooth, flexible.Pass through dissolution rate instrument for several times
Detect its release, release is all higher than 90%, and higher than NF standard, and erythromycin release is steady, after long-term storage its
Release change is little, efficacy stability.
2nd, production craft step of the present invention is few, flow is simple, easily operated.
Embodiment
Embodiment 1
Make a kind of erythromycin enteric-coated tabletses, substrate component is (with the gauge of erythromycin enteric-coated tabletses finished product 100,000)：Erythromycin：
12.5 (BOUs), starch：2.5kg, hydroxypropyl cellulose：1kg, Tween-80：0.21kg, magnesium stearate：0.3kg, talcum
Powder：0.8kg；
Enteric coating component is (with the gauge of erythromycin enteric-coated tabletses finished product 100,000)：Polyacrylic resin (II)：0.81kg, tell
Temperature -80：0.16kg, diethyl phthalate：0.16kg, castor oil：0.48kg, talcum powder：0.59kg, concentration more than 90%
Ethanol：15kg.
Preparation method step is as follows：
1st, enteric coating is made：By polyacrylic acid resin (II) 0.81kg, Tween-80 0.16kg, diethyl phthalate
0.16kg, castor oil 0.48kg, talcum powder 0.59kg mixing, after adding the ethanol 15kg dissolvings of concentration 90%, it is put into colloid mill
Middle grinding several times, is inserted in agitator tank after crossing 300 mesh sieves, is stirred until homogeneous by peristaltic pump bright, obtain erythromycin enteric clothing liquid
It is standby.
2nd, substrate is made：By tri- kinds of erythromycin powder 12.5 (BOU), starch 2.5kg and hydroxypropyl cellulose 1kg
Raw material crushes respectively, is uniformly mixed after crossing 100 mesh sieves, obtains mixture；13% starch slurry 10kg is added in this mixture again
And Tween-80 0.21kg, it is put into after well mixed in granulator and is granulated 10min, obtains wet granular.Gained wet granular is dry in boiling
It is dried in dry device, keeping temperature is 50 DEG C, and water content is about 6% after drying, and after arranging particle with wire netting, adds cunning
Stone flour 0.8kg, magnesium stearate 0.3kg are further well mixed, and insert tabletting machine, obtain erythromycin enteric-coated tabletses substrate.
3rd, it is enteric coated：Above-mentioned gained erythromycin substrate is turned, in seed-coating machine, to start seed-coating machine, by gained enteric coating liquid
Substrate surface is equably sprayed on by spray gun and obtains finished product erythromycin enteric-coated tabletses.
Embodiment 2
A kind of erythromycin enteric-coated tabletses are made, substrate component is：Erythromycin：12.5 (BOUs), starch：2.8kg, hydroxypropyl are fine
Dimension element：1.2kg, Tween-80：0.22kg, magnesium stearate：0.35kg, talcum powder：1.2kg；
Enteric coating component is：Polyacrylic resin (II)：0.82kg, Tween-80：0.16kg, diethyl phthalate：
0.18kg, castor oil：0.51kg, talcum powder：0.61kg, the ethanol of concentration more than 90%：15.2kg.
Preparation method step is as follows：
1st, enteric coating solution is prepared：By polyacrylic acid resin (II) 0.82kg, Tween-80 0.16kg, diethyl phthalate
0.18kg, castor oil 0.51kg, talcum powder 0.61kg mixing, after adding the ethanol 15.2kg dissolvings of concentration 90%, it is put into colloid
Ground in mill several times, inserted after crossing 200 mesh sieves in agitator tank, be stirred until homogeneous by peristaltic pump bright, obtain erythromycin enteric clothing
Liquid is standby.
2nd, substrate is made：By erythromycin powder 12.5 (BOU), starch 2.8kg and hydroxypropyl cellulose 1.2kg tri-
Kind raw material crushes respectively, is uniformly mixed after crossing 80 mesh sieves, obtains mixture；13% starch slurry 10kg is added in this mixture again
And Tween-80 0.22kg, it is put into after well mixed in granulator and is granulated 12min, obtains wet granular.Gained wet granular is dry in boiling
It is dried in dry device, keeping temperature is 55 DEG C, and water content is about 5% after drying, and after arranging particle with wire netting, adds cunning
Stone flour 1.2kg, magnesium stearate 0.35kg are further well mixed, and insert tabletting machine, obtain erythromycin enteric-coated tabletses substrate.
3rd, it is enteric coated：Above-mentioned gained erythromycin substrate is turned, in seed-coating machine, to start seed-coating machine, by gained enteric coating liquid
Substrate surface is equably sprayed on by spray gun and obtains finished product erythromycin enteric-coated tabletses.
Embodiment 3
A kind of erythromycin enteric-coated tabletses are made, substrate component is：Erythromycin：12.5 (BOUs), starch：2.6kg, hydroxypropyl are fine
Dimension element：1.3kg, Tween-80：0.22kg, magnesium stearate：0.35kg, talcum powder：1.2kg；
Enteric coating component is：Polyacrylic resin (II)：0.83kg, Tween-80：0.18kg, diethyl phthalate：
0.18kg, castor oil：0.55kg, talcum powder：0.65kg, the ethanol of concentration more than 90%：15.5kg.
Preparation method step is as follows：
1st, enteric coating solution is prepared：By polyacrylic acid resin (II) 0.83kg, Tween-80 0.18kg, diethyl phthalate
0.18kg, castor oil 0.55kg, talcum powder 0.65kg mixing, after adding the ethanol 15.5kg dissolvings of concentration 90%, it is put into colloid
Ground in mill several times, inserted after crossing 100 mesh sieves in agitator tank, be stirred until homogeneous by peristaltic pump bright, obtain erythromycin enteric clothing
Liquid is standby.
2nd, substrate is made：By erythromycin powder 12.5 (BOU), starch 2.6kg and hydroxypropyl cellulose 1.3kg tri-
Kind raw material crushes respectively, is uniformly mixed after crossing 80 mesh sieves, obtains mixture；13.5% starch slurry is added in this mixture again
12kg and Tween-80 0.22kg, it is put into after well mixed in granulator and is granulated 12min, obtain wet granular.Gained wet granular is being boiled
Rise in drier and be dried, keeping temperature is 55 DEG C, and water content is about 5% after drying, and after arranging particle with wire netting, then is added
Enter talcum powder 1.2kg, magnesium stearate 0.35kg is further well mixed, and inserts tabletting machine, obtain erythromycin enteric-coated tabletses substrate.
3rd, it is enteric coated：Above-mentioned gained erythromycin substrate is turned, in seed-coating machine, to start seed-coating machine, by gained enteric coating liquid
Substrate surface is equably sprayed on by spray gun and obtains finished product erythromycin enteric-coated tabletses.
Embodiment 4
A kind of erythromycin enteric-coated tabletses are made, substrate component is：Erythromycin：12.5 (BOUs), starch：3.0kg, hydroxypropyl are fine
Dimension element：1.5kg, Tween-80：0.25kg, magnesium stearate：0.50kg, talcum powder：1.5kg；
Enteric coating component is (with the gauge of erythromycin enteric-coated tabletses finished product 100,000)：Polyacrylic resin (II)：0.84kg, tell
Temperature -80：0.20kg, diethyl phthalate：0.20kg, castor oil：0.60kg, talcum powder：0.70kg, concentration more than 90%
Ethanol：16kg.
Preparation method step is as follows：
1st, enteric coating solution is prepared：By polyacrylic acid resin (II) 0.84kg, Tween-80 0.20kg, diethyl phthalate
0.20kg, castor oil 0.60kg, talcum powder 0.70kg mixing, after adding the ethanol 16kg dissolvings of concentration 90%, it is put into colloid mill
Middle grinding several times, is inserted in agitator tank after crossing 100 mesh sieves, is stirred until homogeneous by peristaltic pump bright, obtain erythromycin enteric clothing liquid
It is standby.
2nd, substrate is made：By erythromycin powder 12.5 (BOU), starch 3.0kg and hydroxypropyl cellulose 1.5kg tri-
Kind raw material crushes respectively, is uniformly mixed after crossing 100 mesh sieves, obtains mixture；13.5% starch slurry is added in this mixture again
13kg and Tween-80 0.25kg, it is put into after well mixed in granulator and is granulated 15min, obtain wet granular.Gained wet granular is being boiled
Rise in drier and be dried, keeping temperature is 60 DEG C, and water content is about 5% after drying, and after arranging particle with wire netting, then is added
Enter talcum powder 1.5kg, magnesium stearate 0.50kg is further well mixed, and inserts tabletting machine, obtain erythromycin enteric-coated tabletses substrate.
3rd, it is enteric coated：Above-mentioned gained erythromycin substrate is turned, in seed-coating machine, to start seed-coating machine, by gained enteric coating liquid
Substrate surface is equably sprayed on by spray gun and obtains finished product erythromycin enteric-coated tabletses.
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment.But it is every without departing from technical solution of the present invention content, the technical spirit according to the present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.
Claims (6)
1. a kind of erythromycin enteric preparation, is made up of substrate and enteric coating two parts, it is characterised in that：Substrate composition weight number
Meter：Erythromycin：12.5 parts, starch：2.5~3.0 parts, Tween-80：0.21~0.25 part, hydroxypropyl cellulose：1~1.5 part,
Magnesium stearate：0.3~0.5 part, talcum powder：0.8~1.5 part；Enteric coating composition weight number meter：Polyacrylic resin (II)：
0.81~0.84 part, ethanol：15~16 parts, Tween-80：0.16~0.2 part, diethyl phthalate：0.16~0.2 part,
Castor oil：0.48~0.6 part, talcum powder：0.59~0.7 part.
A kind of 2. erythromycin enteric preparation according to claim 1, it is characterised in that：Substrate component includes：Erythromycin：12.5
Part, starch：2.7 part, Tween-80：0.23 part, hydroxypropyl cellulose：1.2 parts, magnesium stearate：0.4 part, talcum powder：1.1 part；
Enteric coating composition weight number meter：Polyacrylic resin (II)：0.82 part, the ethanol of concentration more than 90%：15 parts, Tween-80：
0.17 part, diethyl phthalate：0.18 part, castor oil：0.54 part, talcum powder：0.62 part.
A kind of 3. preparation method of erythromycin enteric preparation according to claim 2, it is characterised in that：Making step is as follows：
1）Prepare enteric coating solution：By polyacrylic resin (II), Tween-80, diethyl phthalate, castor oil and talcum
Powder is mixed according to recipe ingredient aequum, adds the ethanol dissolving of concentration more than 90%, and mixing in colloid mill is put into after dissolving and is ground
Mill several times, crosses 100~300 mesh sieves, the mixture after sieving is transferred into agitator tank, stirred by peristaltic pump, after stirring
Enteric coating liquid is standby；
2）Make substrate：
After a crushes three kinds of erythromycin powder, starch and hydroxypropyl cellulose raw materials, sieved respectively now 80~100, three
Uniformly mixing, adds adhesive and disintegrant is well mixed, and is then transferred to 10~15min of granulation in granulator, obtains wet granular；
Wet granular is dried b in ebullated dryer, controls 50~60 DEG C of temperature, make its water content be maintained at 5%~
6%, particle then is arranged with wire netting, arranges to finish to add after lubricant further mixes and uses tabletting machine, obtain substrate；
3）It is enteric coated：Step 2.2 gained erythromycin substrate is placed in seed-coating machine, starts seed-coating machine, by step 1）Gained intestines
Molten clothing liquid is equably sprayed on substrate surface finished product by spray gun.
A kind of 4. preparation method of erythromycin enteric preparation according to claim 3, it is characterised in that：Step 2）Institute in a
The adhesive stated is 13~13.5% starch slurry, addition (with the gauge of erythromycin enteric-coated tabletses finished product 100,000) for 10~
13kg。
A kind of 5. preparation method of erythromycin enteric preparation according to claim 3, it is characterised in that：Step 2）Institute in a
The disintegrant stated refers to Tween-80.
A kind of 6. preparation method of erythromycin enteric preparation according to claim 3, it is characterised in that：Step 2）Institute in b
The lubricant stated refers to magnesium stearate and talcum powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610492112.2A CN107536822A (en) | 2016-06-29 | 2016-06-29 | A kind of erythromycin enteric preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610492112.2A CN107536822A (en) | 2016-06-29 | 2016-06-29 | A kind of erythromycin enteric preparation |
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| Publication Number | Publication Date |
|---|---|
| CN107536822A true CN107536822A (en) | 2018-01-05 |
Family
ID=60961834
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610492112.2A Pending CN107536822A (en) | 2016-06-29 | 2016-06-29 | A kind of erythromycin enteric preparation |
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| Country | Link |
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| CN (1) | CN107536822A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123772A (en) * | 2019-05-07 | 2019-08-16 | 安徽金太阳生化药业有限公司 | A kind of erythromycin enteric-coated tablets and preparation method thereof |
-
2016
- 2016-06-29 CN CN201610492112.2A patent/CN107536822A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123772A (en) * | 2019-05-07 | 2019-08-16 | 安徽金太阳生化药业有限公司 | A kind of erythromycin enteric-coated tablets and preparation method thereof |
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Application publication date: 20180105 |