CN107485619A - A kind of B family vitamin compound and preparation method thereof - Google Patents
A kind of B family vitamin compound and preparation method thereof Download PDFInfo
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- CN107485619A CN107485619A CN201710722822.4A CN201710722822A CN107485619A CN 107485619 A CN107485619 A CN 107485619A CN 201710722822 A CN201710722822 A CN 201710722822A CN 107485619 A CN107485619 A CN 107485619A
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- 229940088594 vitamin Drugs 0.000 title claims abstract description 25
- 229930003231 vitamin Natural products 0.000 title claims abstract description 25
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 25
- 239000011782 vitamin Substances 0.000 title claims abstract description 25
- 102000040350 B family Human genes 0.000 title claims abstract description 17
- 108091072128 B family Proteins 0.000 title claims abstract description 17
- -1 vitamin compound Chemical class 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 5
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 20
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims abstract description 18
- 239000011715 vitamin B12 Substances 0.000 claims abstract description 13
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 11
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960000304 folic acid Drugs 0.000 claims abstract description 10
- 239000011724 folic acid Substances 0.000 claims abstract description 10
- 235000019152 folic acid Nutrition 0.000 claims abstract description 10
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229940055726 pantothenic acid Drugs 0.000 claims abstract description 9
- 239000011713 pantothenic acid Substances 0.000 claims abstract description 9
- 235000019161 pantothenic acid Nutrition 0.000 claims abstract description 9
- 239000011691 vitamin B1 Substances 0.000 claims abstract description 9
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 9
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011570 nicotinamide Substances 0.000 claims abstract description 8
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 8
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 8
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 3
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims abstract description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 11
- 239000005913 Maltodextrin Substances 0.000 claims description 11
- 229940035034 maltodextrin Drugs 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 4
- 235000019156 vitamin B Nutrition 0.000 abstract description 35
- 239000011720 vitamin B Substances 0.000 abstract description 35
- 229930003270 Vitamin B Natural products 0.000 abstract description 11
- 230000036541 health Effects 0.000 abstract description 11
- 239000013589 supplement Substances 0.000 abstract description 11
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 9
- 150000001875 compounds Chemical class 0.000 abstract description 6
- 235000005911 diet Nutrition 0.000 abstract description 5
- 230000037213 diet Effects 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 4
- 239000000047 product Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract description 2
- 229940046001 vitamin b complex Drugs 0.000 description 24
- 230000000694 effects Effects 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 230000004060 metabolic process Effects 0.000 description 8
- 239000011575 calcium Substances 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 235000004251 balanced diet Nutrition 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000005515 coenzyme Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000004126 nerve fiber Anatomy 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000031845 Pernicious anaemia Diseases 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000037354 amino acid metabolism Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000004793 poor memory Effects 0.000 description 1
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to medicine of health products field, and in particular to a kind of B family vitamin compound and preparation method thereof.Vitamin B compound in existing health-product market is often according to the ratio between the various vitamin Bs of the physiology and food feature of general population design, to meet most of Man's Demands.And not necessarily it is adapted to this vitamin B compound for popular design for the more special crowd of some diet or physical condition.The present invention is by vitamin B1, vitamin B2, vitamin B6, niacinamide, pantothenic acid and folic acid tablet A is made；By vitamin B12Tablet B is made with Ca.User can select that tablet A is used alone according to oneself diet and health feature or use tablet A and tablet B simultaneously, so as to realize the individual difference according to everyone, more targetedly carry out the supplement of vitamin B.The invention is applied to the daily supplement of various crowd's vitamin Bs.
Description
Technical field
The invention belongs to medicine of health products field, and in particular to a kind of B family vitamin compound and preparation method thereof.
Background technology
Vitamin B complex (VB) has more than 12 kinds, has nine kinds by what the world unanimously generally acknowledged, is water soluble vitamin entirely,
The time being detained in vivo only has a few hours, it is necessary to supplement daily.B races are the essential nutrients of all tissues, are foods
The key that thing releases energy.It is coenzyme entirely, participates in the metabolism of sugar, protein and fat in vivo, therefore is listed in a family.Sieve
Outstanding doctor William points out that all cells are identical to VB demand.Vitamin B includes vitamin B1, vitamin B2, dimension life
Plain B6, vitamin B12, nicotinic acid, pantothenic acid, folic acid etc..These B family vitamins are to promote metabolism in vivo, sugar, fat, protein etc.
Change into indispensable material during heat.If the content of internal vitamin B is sufficient, it is possible to keeping tensions down, worried feelings
Thread, and the endurance for noise can be improved.Contribute to gastrointestinal peristalsis, the symptom of relief of constipation.If lack vitamin
B, then cell function reduction at once, causes dysbolism, and at this moment idle stagnant and poor appetite occurs in human body.All vitamin Bs
It must play a role simultaneously, referred to as VB fusion.Certain VB is individually taken in, due to the activity increase of cell, so that right
Other VB demand and then increases, so various VB effect is complementary.Therefore supplement VB is had using vitamin B compound
There is good effect.
But the vitamin B compound in existing health-product market is often the physiology and food feature according to general population
The ratio between various VB is designed, to meet most of Man's Demands.It is and more special for some diet or health
Crowd is not necessarily adapted to this vitamin B compound for popular design.Such as the vitamin B that human body oneself can not synthesize12Though
So it is widely present in animal food, but it absorbs more difficulty.For having the balanced diet and the crowd of stomach health
For will not typically be deficient in vitamin B12, but absorbing bad crowd for vegetarian, old man or stomach may then lack
Vitamin B12。
The content of the invention
In order to solve the problems, such as that the vitamin B compound of above-mentioned single formula can not meet the needs of all groups supplement VB,
The present invention provides a kind of B family vitamin compound, and supplement VB species and dosage can be adjusted according to the situation of user.
The present invention also provides a kind of method for preparing the B family vitamin compound.
The technical solution adopted by the present invention is as follows：
A kind of B family vitamin compound, it is characterised in that include tablet A and tablet B.
The tablet A includes the raw material of following parts by weight：
Vitamin B111.2-19.5mg vitamin B1Grow up with promotion；Help digest, particularly carbohydrate disappears
Change；Improve mental status；Maintain the normal of nerve fiber, muscle and cardiomotility；Mitigate airsick, seasick；Alleviate relevant dentistry
Postoperative pain；And contribute to treatment to herpes zoster etc. beneficial effect.
Vitamin B211.2-19.5mg vitamin B2Physiological action include：Vivo biodistribution oxidation and energetic supersession are participated in,
It is relevant with the metabolism of carbohydrate, protein, nucleic acid and fat, utilization rate of the human body to protein can be improved, promotes growth
Development, safeguard the integrality of skin and cell membrane.Function with protection skin follicle mucous membrane and sebaceous glands；Participate in the life of cell
Long metabolism, it is injected organism tissue metabolism and the necessary nutrient repaired, such as strengthens liver function, the adrenergic secretion of regulation；Participate in
Vitamin B6With the metabolism of nicotinic acid, be B family vitamin coordinative role a model.
Vitamin B60-9.36mg, vitamin B6Be advantageous to hydrochloric acid synthesis and fat, the absorption of protein, assist to maintain body
Internal sodium-potassium balance, promote the formation of red blood cell.Also help in addition and solve the inconvenience that internal water delay is brought.Help brain and
The physiological function that immune system is brought into normal play.Cell is controlled to increase and divide.The synthesis of the inhereditary materials such as DNA, RNA also be unable to do without
Vitamin B6.In addition vitamin B6Many kinds of internal enzymes can also be activated, and contribute to vitamin B12Absorption.
Niacinamide 0-46.8mg, good blood circulation is maintained, skin health, helps nerve fiber to exercise normal physiological machine
Energy.In addition carbohydrate, fat, protein-based metabolism and hydrochloric acid manufacture also be unable to do without niacinamide.Participate in bile and gastric juice sex hormone closes
Into can reduce cholesterol, improve blood circulation.It is also helpful for schizophrenia, poor memory, the treatment of mental disease.
Pantothenic acid 0-21.5mg, the effect of pantothenic acid include：It is nervous to eliminate body condition, may participate in adrenal gland, the manufacture of hormone and anti-
The formation of body.And the utilization of vitamin is assisted, and the conversion of carbohydrate, fat and protein energy.It is all cells of tissue
It is indispensable.Be advantageous to neurotransmitter, while be also the important composition element of coenzyme.Enhancing muscle power, prevents that some forms are poor
Blood occurs, and maintains alimentary canal normal function.
Folic acid 0-0.33mg, coenzyme of the folic acid as a carbon list enzyme system in internal biochemical reaction.Participate in purine and thymus gland is phonetic
The synthesis of pyridine, further synthetic DNA, RNA.Participation amino acid metabolism, participation hemoglobin and methyl compound such as adrenaline,
The synthesis of choline, creatine etc..
The VB ratios used in tablet A, the normal ingestion amount in diet is taken into full account, made according to being cooperateed between VB
With careful design.Meet human body needs, effectively increase comprehensive utilization of the adult to VB.For having the balanced diet, stomach health
Population can individually take in tablet A to supplement the daily required VB of human body.
The tablet B includes the raw material of following parts by weight：
Vitamin B122.55-4.08ug its effect includes：Promote methyl transfer；Promote development and the maturation of red blood cell,
Human body hematopoietic function is in normal condition, prevent pernicious anaemia；Safeguard nervous system health；Exist in the form of coenzyme, can
To increase the utilization rate of folic acid, promote the metabolism of carbohydrate, fat and protein；There is activated amino acid and rush
Enter the biosynthesis of nucleic acid, the synthesis of protein can be promoted, it plays an important role to growing for infant；Eliminate agitation not
Peace, focuses on, enhancing memory and the sense of equilibrium；It is that nervous function perfects indispensable vitamin, participates in neural group
Knit a kind of formation of middle lipoprotein.
The purpose that calcium constituent is added in Ca 0-95.25mg, tablet B is to promote vitamin B12Absorption.
The obvious B that is deficient in vitamin such as bad people is absorbed for vegetarian, old man or stomach12Crowd, tablet A can be used
Arrange in pairs or groups and use with tablet B, so as to reach the effect for more comprehensively, more accurately and preferably supplementing VB.In addition, it can also be built according to doctor
View, the usage amounts of adjustment tablet A and tablet B respectively, according to everyone individual difference, is more targetedly supplemented.
Preferably, the tablet A includes the raw material of following parts by weight：Vitamin B111.2-19.5mg vitamin
B211.2-19.5mg vitamin B65.4-9.36mg, niacinamide 27-46.8mg, pantothenic acid 12.4-21.5mg and folic acid 0.18-
0.33mg.The proportioning of the preferred scheme is more balanced, is more beneficial for playing VB fusion, strengthens the effect of supplement.
Preferably, the tablet B includes the raw material of following parts by weight：Vitamin B122.55-4.08ug, Ca 64-
95.25mg.The preferred scheme is more beneficial for playing the effect of Ca elements, strengthens B12Absorption.
It is further preferred that maltodextrin is also included in the tablet A and tablet B, the weight of maltodextrin in the tablet A
Measure the parts by weight 0-100mg of maltodextrin in part 0-100mg, the tablet B.Maltodextrin is as filler, main function
For filling the weight and volume of tablet, consequently facilitating tabletting.
Present invention also offers the method for preparing the B family vitamin compound, comprise the following steps：
[1] the tablet A each components included are well mixed in tablet A ratio, cross 60 mesh sieves；By the tablet B
Comprising each component be well mixed in tablet B ratio, cross 60 mesh sieves；
[2] filler is added in the tablet A obtained into step [1] mixture, be well mixed；Into step [1]
To tablet B mixture in add filler, be well mixed；
[3] tabletting is made after the tablet A obtained in step [2] and tablet B mixture being carried out micro- granulation, dried respectively
Tablet A and tablet B.
The preparation method is simple, required equipment is simple, cost is low and manufactured tablet quality is stable.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
, should 1. the active component in a kind of B family vitamin compound disclosed in this invention is the necessary material of human body
B B-complex can health care, and can strengthening body resistance, and having no toxic side effect.Used VB ratios, take into full account
Normal ingestion amount in diet, acts synergistically according between VB, careful design.Meet human body needs, effectively increase into
Comprehensive utilization of the people to VB, so as to improve health value.
2. tablet A and tablet B is made in different VB by the present invention.For having the balanced diet, the population of stomach health can
Tablet A is individually taken in supplement the daily required VB of human body.It is obvious scarce that bad people etc. is absorbed for vegetarian, old man or stomach
Weary vitamin B12Crowd, tablet A and tablet B collocation can be used to use, can reach more comprehensively, more accurate and more preferable supplement
VB effect.In addition, it can also be suggested according to doctor, the usage amounts of adjustment tablet A and tablet B respectively, according to everyone individual
Difference, more targetedly supplemented.
3. the invention provides the method for preparing the B family vitamin compound, have simple, required equipment it is simple, into
The advantages of this low and manufactured tablet quality is stable.
Embodiment
All features disclosed in this specification, or disclosed all methods or during the step of, except mutually exclusive
Feature and/or step beyond, can combine in any way.
Embodiment 1
By vitamin B111.2mg, vitamin B211.2mg, vitamin B65.4mg, niacinamide 27mg, pantothenic acid 12.4mg
It is well mixed with folic acid 0.18mg, crosses 60 mesh sieves；Add maltodextrin 50mg mixing, by micro- granulation, dry after tabletting be made
Tablet A.
By vitamin B122.55ug and Ca 10mg are well mixed, and cross 60 mesh sieves；Maltodextrin 50mg mixing is added, is passed through
Tablet B is made in tabletting after micro- granulation, drying.
Embodiment 2
By vitamin B119.5mg, vitamin B219.5mg, vitamin B69.36mg, niacinamide 46.8mg, pantothenic acid
21.5mg and folic acid 0.33mg are well mixed, and cross 60 mesh sieves；Maltodextrin 100mg mixing is added, is pressed after micro- granulation, drying
Tablet A is made in piece.
By vitamin B124.08ug and Ca 95.25mg are well mixed, and cross 60 mesh sieves；Maltodextrin 100mg mixing is added,
Tablet B is made in tabletting after micro- granulation, drying.
For having the balanced diet, the population of stomach health can individually take in tablet A to supplement the daily required VB of human body.
The obvious B that is deficient in vitamin such as bad people is absorbed for vegetarian, old man or stomach12Crowd, tablet A and tablet B can be used
Collocation uses.
It is embodiments of the invention as described above.The present invention is not limited to the above-described embodiments, anyone should learn that
The change made under the enlightenment of the present invention, the technical schemes that are same or similar to the present invention, each falls within the present invention
Protection domain within.
Claims (5)
- A kind of 1. B family vitamin compound, it is characterised in that comprising tablet A and tablet B,The tablet A includes the raw material of following parts by weight：Vitamin B1 11.2-19.5mgVitamin B2 11.2-19.5mgVitamin B6 0-9.36mgNiacinamide 0-46.8mgPantothenic acid 0-21.5mgFolic acid 0-0.33mgThe tablet B includes the raw material of following parts by weight：Vitamin B12 2.55-4.08ugCa 0-95.25mg。
- 2. according to the B family vitamin compound described in claim 1, it is characterised in that the tablet A includes following parts by weight Raw material：Vitamin B111.2-19.5mg vitamin B211.2-19.5mg vitamin B65.4-9.36mg niacinamide 27- 46.8mg, pantothenic acid 12.4-21.5mg and folic acid 0.18-0.33mg.
- 3. according to the B family vitamin compound described in claim 1, it is characterised in that the tablet B includes following parts by weight Raw material：Vitamin B122.55-4.08ug, Ca 64-95.25mg.
- 4. according to the B family vitamin compound described in any one of claims 1 to 3, it is characterised in that：The tablet A and tablet B In also include maltodextrin, in the tablet A in the parts by weight 0-100mg, the tablet B of maltodextrin maltodextrin weight Part 0-100mg.
- A kind of 5. method of the B family vitamin compound prepared described in claim 1, it is characterised in that comprise the following steps：[1] the tablet A each components included are well mixed in tablet A ratio, cross 60 mesh sieves；The tablet B is included Each component be well mixed in tablet B ratio, cross 60 mesh sieves；[2] filler is added in the tablet A obtained into step [1] mixture, be well mixed；Obtained into step [1] Filler is added in tablet B mixture, is well mixed；[3] tablet is made in tabletting after the tablet A obtained in step [2] and tablet B mixture being carried out micro- granulation, dried respectively A and tablet B.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464430A (en) * | 2018-11-23 | 2019-03-15 | 南京协同生物科学研究院有限公司 | A kind of non-human primate's vitamin supplement preparation and its preparation method and application |
| CN110250520A (en) * | 2019-06-19 | 2019-09-20 | 安徽康博特保健食品有限公司 | A kind of adult type B family vitamin health food chewable tablets and preparation method thereof |
| CN111067874A (en) * | 2020-01-10 | 2020-04-28 | 威海百合生物技术股份有限公司 | Vitamin B direct-compression tablet and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310024A (en) * | 2001-02-21 | 2001-08-29 | 深圳市海川实业股份有限公司 | Microencapsulated compound nutrient complementing agent |
| JP2006096682A (en) * | 2004-09-28 | 2006-04-13 | Riken Vitamin Co Ltd | Vitamins containing composition |
| CN101401809A (en) * | 2008-11-12 | 2009-04-08 | 杭州民生药业集团有限公司 | Preparation for composition of vitamin and mineral matter |
| CN103463120A (en) * | 2013-09-03 | 2013-12-25 | 福州闽海药业有限公司 | Stable-type composite vitamin B tablet and preparation method thereof |
-
2017
- 2017-08-22 CN CN201710722822.4A patent/CN107485619A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310024A (en) * | 2001-02-21 | 2001-08-29 | 深圳市海川实业股份有限公司 | Microencapsulated compound nutrient complementing agent |
| JP2006096682A (en) * | 2004-09-28 | 2006-04-13 | Riken Vitamin Co Ltd | Vitamins containing composition |
| CN101401809A (en) * | 2008-11-12 | 2009-04-08 | 杭州民生药业集团有限公司 | Preparation for composition of vitamin and mineral matter |
| CN103463120A (en) * | 2013-09-03 | 2013-12-25 | 福州闽海药业有限公司 | Stable-type composite vitamin B tablet and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李宁: "《李宁细说孕产妇怎么吃》", 31 May 2015, 青岛出版社 * |
| 陈锦珊等: "《军医、卫生员背囊使用手册》", 31 August 2014, 第二军医大学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464430A (en) * | 2018-11-23 | 2019-03-15 | 南京协同生物科学研究院有限公司 | A kind of non-human primate's vitamin supplement preparation and its preparation method and application |
| CN110250520A (en) * | 2019-06-19 | 2019-09-20 | 安徽康博特保健食品有限公司 | A kind of adult type B family vitamin health food chewable tablets and preparation method thereof |
| CN111067874A (en) * | 2020-01-10 | 2020-04-28 | 威海百合生物技术股份有限公司 | Vitamin B direct-compression tablet and preparation method thereof |
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