CN107456203A - A kind of laser reflection spectrum gynecatoptron - Google Patents
A kind of laser reflection spectrum gynecatoptron Download PDFInfo
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- CN107456203A CN107456203A CN201610385181.3A CN201610385181A CN107456203A CN 107456203 A CN107456203 A CN 107456203A CN 201610385181 A CN201610385181 A CN 201610385181A CN 107456203 A CN107456203 A CN 107456203A
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- 238000000985 reflectance spectrum Methods 0.000 claims abstract description 15
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- 208000019065 cervical carcinoma Diseases 0.000 description 6
- 238000013500 data storage Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000001574 biopsy Methods 0.000 description 4
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- 239000013307 optical fiber Substances 0.000 description 4
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- 238000002560 therapeutic procedure Methods 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 2
- 238000003759 clinical diagnosis Methods 0.000 description 2
- 238000002573 colposcopy Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
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- 230000009467 reduction Effects 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
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- 230000003993 interaction Effects 0.000 description 1
- 208000020082 intraepithelial neoplasia Diseases 0.000 description 1
- 238000010330 laser marking Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
- A61B1/0676—Endoscope light sources at distal tip of an endoscope
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/303—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the vagina, i.e. vaginoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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Abstract
The invention discloses a kind of laser reflection spectrum gynecatoptron.The present invention uses multiwavelength laser synthesis to be used as light source, laser scanning assembly is controlled to carry out point by point scanning to cervical lesionses position, it is synchronous to detect point-by-point reflectance spectrum, the intensity that optical maser wavelength is corresponded in the point-by-point acquisition reflectance spectrum of analysis carrys out the information of each passage of combined color image, and then generates fine definition cervical lesionses image.The present invention can complete detection process by assist personnels such as fill light light source, imaging sensors.Laser scanning assembly, spectra collection component, lighting source, imaging sensor close tread assembly to realize that light closes beam by light path, and light is communicated by positioning intubation with diseased region.The present invention is irradiated to that diseased region facula area is small, brightness is high, greatly improves detection sensitivity and the degree of accuracy using the high brightness of laser, monochromaticjty, the characteristic of good directionality.
Description
Technical field
The invention belongs to medical treatment detection device field, more particularly, to a kind of colposcopy measurement equipment that cervical tissue reflectance spectrum is excited using laser scanner.
Background technology
Cervical carcinoma is the second largest common cancer of women, the generation of cervical carcinoma and human papilloma virus（HPV）Infection it is relevant, some high-risk HPV infected patients, in persistent infection, precancerous lesion and cervical carcinoma easily occurs.
Cervical carcinoma is one of a small number of malignant tumours that can be by preventing reduction morbidity and mortality.The normal process of current diagnosis cervical carcinoma is to find suspicious lesions by gynecatoptron, and takes biopsy to make pathological section to suspicious lesions and make a definite diagnosis again.Ordinary electronic gynecatoptron is finding that the sensitiveness of intraepithelial neoplasia (cin), specificity are general, easily occurs failing to pinpoint a disease in diagnosis phenomenon, it is also possible to cause unnecessary cervical biopsy, injury is brought to patient.
Spectroscopy technology is as a kind of Non-Invasive clinical diagnosis technology, lesion is identified by the spectral signature of tissue and and guides pathological tissues biopsy, cervical lesionses positive rates of biopsy is greatly improved, rate of missed diagnosis is reduced, a kind of reliable diagnostic method is provided for cervical lesionses clinic.Light spectrum image-forming can have been broken away from common gynecatoptron and limited by the constraint of doctor's clinical experience by carrying out computer objective analysis to spectrum.
Reflection spectrum curve means the ability of detection position reflecting electromagnetic radiation, the characteristic changed with the electromagnetic wavelength reflected.The change of wavelength is such as represented with abscissa, ordinate represents its reflectivity（Or reflecting brightness coefficient）It may make up the curve of reflection reflective spectral property, referred to as reflectance spectrum（Characteristic）Curve.Material of different nature, or same alike result material in its composition, color, surface texture, the property of water-bearing（Rate）Etc. it is different when, its reflective spectral property is also different, forms the difference of reflection spectrum curve.The present invention is according to the reflectance spectrum information for obtaining and recording different lesions position different-waveband, by analyzing its otherness, to identify lesion attribute.
Traditional colposcopy measurement equipment based on camera, using xenon lamp or LED as light source, using digital camera as imaging device, imaging effect is poor, and accuracy of detection is low, it is difficult to detect small lesion.The present invention uses laser as light source, by focusing on to the progress point by point scanning of detection diseased region and recording the reflectance spectrum received point by point.Because laser can focus on very little, and synthetic laser has narrower spectral bandwidth, the information that spectrum includes is more much greater than the information content that general camera collection image includes, it can accurately analyze to obtain point-by-point precise information by spectrum analysis, so as to generate the uterine neck image of fine definition, the further treatment of doctor is instructed.Reflectance spectrum provides important foundation for clinical diagnosis as most important spectral information.
The content of the invention
The present invention provide it is a kind of can not damaged, accurate, the cervical lesionses detector of high sensitivity, laser spectrum gynecatoptron, including：Positioning intubation, light path close tread assembly, laser scanning assembly, spectra collection component, lighting source, imaging sensor and control system.
Positioning intubation, positioning intubation are the hollow tube of both ends open, for the relative position of fixed test instrument and patient's uterine neck, and provide light path working space.
Light path closes tread assembly, and light path closes the hollow tube that tread assembly is both ends open, includes multi-disc light combination mirror, and side is provided with multiple side openings, and wherein one end of light path conjunction tread assembly is connected with one end of positioning intubation；
Laser scanning assembly, laser scanning assembly closes tread assembly with light path and is connected, for carrying out point by point scanning to diseased region.
Spectra collection component, spectra collection component close tread assembly with light path and are connected, be high speed spectrometer, worked asynchronously with laser scanning assembly, gather reflectance spectrum information in real time.
Imaging sensor, imaging sensor close tread assembly with light path and are connected, and for gathering diseased region image, assist operators are observed；
Lighting source, closes tread assembly with light path and is connected, and illumination is provided for collection diseased region image.
Control system, it is connected with laser scanning assembly, spectra collection component, lighting source, imaging sensor, coordinates working asynchronously for laser scanning assembly and spectra collection component for controlling, coordinate control lighting source and imaging sensor cooperating.
Further, laser scanning assembly includes generating laser and optical scan vibration lens.Generating laser is the laser of multiple wavelength, the wavelength of each generating laser is different, from the laser of 300nm to 1700nm multiple wavelength, by fiber coupler by laser coupled into a branch of optical fiber, optical fiber output port becomes directional light by lens again, optical scan vibration lens is injected, after two lens reflectings of optical scan vibration lens, tread assembly is closed into light path.
Further, control system changes the launch angle of laser by controlling the angle of optical scan vibration lens, and then realizes point by point scanning of the laser in diseased region.
Further, the laser of laser scanning assembly generation is focused on by focus lamp at the port of the other end of positioning intubation.
Further, a diameter of 0.05~0.3mm for the hot spot that laser beam is formed in diseased region.
Further, light path is closed tread assembly and included：
Light path closes tread assembly shell, light path closes tread assembly shell and the tubular structure of both ends open, side is provided with multiple side openings, and one end of light path conjunction tread assembly shell is connected with one end of positioning intubation, light path closes the other end of tread assembly shell and side opening is connected respectively at laser scanning assembly, spectra collection component, lighting source, imaging sensor；The position relationship of each component is not completely fixed, the simply one of which that present example is enumerated, and reasonably changes link position and order that each component closes tread assembly in light path, very small to the influential effect of the present invention, within protection scope of the present invention.Such as exchange the position of spectra collection component and lighting source, exchange the position of lighting source and imaging sensor.
Light combination mirror, light combination mirror is arranged on light path and closes tread assembly enclosure, and the angle that light combination mirror closes tread assembly shell side with light path is 45 degree.It is half anti-/ pellicle mirror to connect laser scanning assembly, spectra collection component, lighting source, the light combination mirror of imaging sensor.
Further, control system can generate the reflectance spectrum pixel value of the point by digital simulation by analyzing the spectrum gathered point by point, reading and laser wavelength identical individual count value.So as to generate the image of detection position.The image can be coloured image or gray level image or pseudo color image.
Further, control system is connected with external data storage device, with real time by the various treatment information data storings in therapeutic process to external data storage device.
The present invention is by lesion portion point by point scanning, having advantages below：
Characteristics of lesion protrudes, due to Laser Focusing point very little, diameter only has 0.05-0.3mm, in the small scope of Laser Focusing, fine lesion can also occupy larger ratio or even be completely filled with, and compared to a wide range of detection lesion, the feature of lesion can be more obvious, the susceptibility of detection is greatly reinforced, it might even be possible to find the cervical carcinoma lesion of early stage.
The laser that the present invention uses is not limited to traditional visible-range, further comprises near infrared light, ultraviolet light wave band, can widely gather the reflectance spectrum information of diseased region.
Brief description of the drawings
Fig. 1 is a kind of structure chart of laser reflection spectrum gynecatoptron of the present invention.
Embodiment
Below in conjunction with diagram and embodiment describe embodiments of the present invention in detail, thereby how application technology means solve technical problem and reach the implementation process of technical effect to the present invention, can fully understand and implement according to this.
The laser reflection spectrum gynecatoptron according to embodiments of the present invention of reference picture 1 includes positioning intubation 1, and light path closes tread assembly 2, laser scanning assembly 3, spectra collection component 4, lighting source 5, imaging sensor 6, control system 7.One end that one end of positioning intubation 1 closes tread assembly 2 with light path is connected, and the side that laser scanning assembly 3 closes tread assembly 2 with light path is connected, spectra collection component 4, lighting source 5, and side, the rear end that imaging sensor 6 closes tread assembly 2 with light path respectively are connected.The diseased region image that control system 7 can obtain according to imaging sensor 3, control laser scanning assembly generation focuses on laser beam flying diseased region, and controls the point-by-point synchronous acquisition of the progress diseased region reflectance spectrum of spectra collection component 4 simultaneously.
Positioning intubation 1 is the hollow tube of both ends open.Positioning intubation 1 is used for the diseased region for positioning patient, is easy to carry out laser scanning to diseased region, and positions the path that intubation further defines laser beam so that laser path is in positioning intubation limited range.For keep detection safely, prevent cross-infection, positioning intubation 1 is used disposable medical apparatus.
Light path, which closes tread assembly 2, includes light path conjunction tread assembly shell and light combination mirror.
Light path closes tread assembly shell, light path closes tread assembly shell and the tubular structure of both ends open, side is provided with multiple side openings, and one end of light path conjunction tread assembly shell is connected with one end of positioning intubation, light path closes the other end of tread assembly shell and side opening is connected respectively at laser scanning assembly, spectra collection component, lighting source, imaging sensor；
Light combination mirror, light combination mirror is arranged on light path and closes tread assembly enclosure, and the angle that light combination mirror closes tread assembly shell side with light path is 45 degree.It is half anti-/ pellicle mirror to connect laser scanning assembly, spectrometer, lighting source, the light combination mirror 201,202,203 of imaging sensor.
First side opening that laser scanning assembly 3 closes tread assembly 2 with light path is connected, for carrying out point by point scanning to diseased region.First side opening is shorter with respect to light path, the unit by laser generator and can programme-control scan control unit form.Laser generator is the different multiple lasers of wavelength, imports optical fiber by a fiber coupler, the wavelength of laser is from 300nm to 1700nm, such as 360nm, 476nm, 532nm, 650nm, 1064nm, 1570nm etc..Laser is converted into directional light in fiber outlet by lens, and enters optical scan vibration lens.
Program-controlled scanning element is optical scan vibration lens equipment, belongs to prior art.Optical scan vibration lens for can the programme-control anglec of rotation mutually perpendicular two panels speculum, the anglec of rotation of eyeglass is controlled by control electric current size, the rotation of two mutually perpendicular directions is realized respectively by two panels speculum, so as to control laser freely projecting in the two-dimensional direction.Current scanline mirror techniques are applied to the fields such as laser marking, stage laser performance, laser 3D printing.
Second side opening that spectra collection component 4 closes tread assembly 2 with light path is connected（It can also be exchanged with the 3rd side opening or open rearward end）, it is high speed spectrometer, is worked asynchronously with laser scanning assembly, gathers the spectral information of laser reflection in real time.Spectra collection unit is high speed light spectrum detecting apparatus, can be with real-time collecting to current spectral information.Pathological tissues reflection laser reflexes to light spectrum detecting apparatus by light combination mirror, combining light imports optical fiber by focusing on, so as to import the entrance of spectrometer, it is then sent through diffraction grating, by the optical dispersion of different wave length and focus on the optical sensor unit of different angle, so as to efficiently obtain reflectance spectrum information.Belong to prior art.
Lighting source 5 provides visible light source, the collection of auxiliary image sensor for pickup area.In order to aid in the normal work of other units, lighting source has following characteristics.1st, using visible ray, operating personnel are facilitated to observe diseased region.2nd, take image, the reduction degree of diseased region high under white light, using LED.Lighting source is closed when the 3rd, gathering reflectance spectrum.
On human-computer interaction interface, indirect labor is operated the image real-time display that imaging sensor 6 is got.
Control system 7 controls laser scanner to carry out point by point scanning, while reads the spectral information that spectra collection unit collects, the corresponding corresponding scan position of each spectral information.The picture of uterine neck is fitted by reading in spectrum with optical maser wavelength identical information.
Preferably, control system 7 and external data storage device（Not shown in figure）It is connected, in real time by caused information data storing in therapeutic process to external data storage device.Control system 7 and external data storage device（Not shown in figure）Connected mode can be that wireless connection can also be wired connection.The treatment information data can be doctor set over the course for the treatment of laser scanning kinematic parameter, the content such as the picture of diseased region or video in therapeutic process, but heretofore described laser scanning kinematic parameter is not limited to this.Treatment data is stored in External memory equipment, help can be provided for case research, and the doctor-patient dispute for that may occur provides evidence.
The course of work illustrated below is as follows：
By the insertion vaginal dilator of positioning intubation 1 and arrive at uterine neck；Control system 7 controls lighting source 5 to be imaged with imaging sensor 6 to diseased region, and imaging data is sent into control system 7；Doctor confirms predetermined detection area by being imaged, and uterine neck image is preserved and starts reflection spectrum detection imaging.Control system 7 controls laser scanning assembly 3 to carry out point by point scanning to diseased region, while controls spectra collection component 4 to synchronize collection to the spectrum of point by point scanning position correspondence.And record its corresponding position of point-by-point spectral information.Control system 7 or host computer calculate point-by-point image information according to the spectral signature of pathology, and synthesize lesion image.
One simple diseased region computation model is as follows, and this model is simple examples, and it is preferred scheme not represent this example, can optimize this computation model by medical experiment.
For example, it is used as light source using the laser that wavelength is 650nm, 532nm, 476nm.
It is that mono- group of observed value of 650nm, 532nm, 476nm is recorded as V={ R, G, B } to spectrally wavelength.Such as R=200, G=100, B=30 are expressed as V={ 200,100,30 }.
Under the premise of the parameter configuration of fixed equipment, detectable substance is replaced into standard white plate first, it is assumed that measure VWhite={RWhite, GWhite, BWhite}={ 2356,5632,1245 }.
Assuming that to the i-th row, jth row are actual to obtain spectral value
Vi,j={Ri,j, Gi,j, Bi,j}={2072,532,267}.There should be Ri,j<=
RWhite、Gi,j<=
GWhite、Bi,j<=
BWhite。
Then there is the image pixel numerical value of the point
Ii,j={ 255*Ri,j/RWhite, 255*Gi,j/GWhite, 255*Bi,j/BWhite}
={255*2072/2356,255*532/5632,255*267/1245}={224,24,56}。
Diseased region image I can be generated according to point-by-point pixel value.
Finally it should be noted that, above example is only describing technical scheme rather than this technology method is limited, the present invention can above extend to other modifications, change, application and embodiment in application, and it is taken as that all such modification, change, application, embodiments all in the range of spirit or teaching of the invention.
Claims (7)
1. a kind of detection method of laser reflection spectrum gynecatoptron, it is characterised in that include laser scanning assembly, spectra collection component, control system；Control system controls spectra collection component synchronization to gather the detection that point-by-point spectrum is used for cervical lesionses by controlling laser scanning assembly to carry out point by point scanning to diseased region.
2. a kind of laser reflection spectrum gynecatoptron, it is characterised in that include laser scanning assembly, spectra collection component, control system；Control system controls spectra collection component synchronization to gather the detection that point-by-point spectrum is used for cervical lesionses by controlling laser scanning assembly to carry out point by point scanning to diseased region.
3. laser reflection spectrum gynecatoptron according to claim 2, characterized by further comprising light path to close tread assembly, light path is closed tread assembly and is connected with laser scanning assembly, spectra collection component, the light path of laser scanning assembly, spectra collection component is closed by beam by light combination mirror, one end that light path closes tread assembly from light path imports uterine neck.
4. laser reflection spectrum gynecatoptron according to claim 3, it is characterised in that also include positioning intubation, the light path exit end that positioning intubation closes tread assembly with light path is connected, provides working space for light path, light path is imported into uterine neck, and play fixation.
5. the laser reflection spectrum gynecatoptron according to claim any one of 2-4, it is characterised in that also including lighting source and imaging sensor, for aiding in doctor to position test position.
6. the reflectance spectrum gynecatoptron according to claim 2-5, it is characterised in that also including remote supervision system, by expert's remote reviewing and detection process can be assisted, it is ensured that the reasonability of detection process.
7. the reflectance spectrum gynecatoptron according to claim 2-6, it is characterised in that also including remote information management system, the detection process collected, result data can be uploaded and preserved.
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| CN201610385181.3A CN107456203A (en) | 2016-06-03 | 2016-06-03 | A kind of laser reflection spectrum gynecatoptron |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371756A (en) * | 2018-02-10 | 2018-08-07 | 中国医学科学院生物医学工程研究所 | A kind of diagnosis and treatment one cervical lesions photodynamic therapy system |
| EP3970601A1 (en) * | 2020-09-21 | 2022-03-23 | Pukyong National University Industry - University Cooperation Foundation | Mobile colposcopy device for early diagnosis of cervical cancer |
-
2016
- 2016-06-03 CN CN201610385181.3A patent/CN107456203A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371756A (en) * | 2018-02-10 | 2018-08-07 | 中国医学科学院生物医学工程研究所 | A kind of diagnosis and treatment one cervical lesions photodynamic therapy system |
| CN108371756B (en) * | 2018-02-10 | 2024-01-30 | 中国医学科学院生物医学工程研究所 | Diagnosis and treatment integrated cervical lesion photodynamic therapy system |
| EP3970601A1 (en) * | 2020-09-21 | 2022-03-23 | Pukyong National University Industry - University Cooperation Foundation | Mobile colposcopy device for early diagnosis of cervical cancer |
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Application publication date: 20171212 |