CN107412345A - A kind of passion fruit seed oil lozenge and preparation method thereof - Google Patents
A kind of passion fruit seed oil lozenge and preparation method thereof Download PDFInfo
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- CN107412345A CN107412345A CN201710599893.XA CN201710599893A CN107412345A CN 107412345 A CN107412345 A CN 107412345A CN 201710599893 A CN201710599893 A CN 201710599893A CN 107412345 A CN107412345 A CN 107412345A
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- passion fruit
- seed oil
- lozenge
- fruit seed
- extract
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to health care buccal tablets technical field, and in particular to a kind of passion fruit seed oil lozenge and preparation method thereof.The passion fruit seed oil lozenge, is made up of following components ratio by weight：10~20 parts of passion fruit seed oil, 20~65 parts of passion fruit extract, 25~65 parts of gorgon euryale seed powder.Passion fruit seed oil lozenge prepared by the present invention is pure natural, without chemical addition agent, in good taste and with concertedness treatment sphagitis effect；Using the method for the present invention, passion fruit raw material availability is high, and technique is simple, production cost is low.
Description
【Technical field】
The present invention relates to health care buccal tablets technical field, and in particular to a kind of passion fruit seed oil lozenge and preparation method thereof.
【Background technology】
Passion fruit, also known as passion fruit (scientific name：Passiflora edulia Sims) be Passifloraceae Passiflora grass
Matter liana, it is about 6 meters；Stem has stria, hairless；5 pieces of petal, it is isometric with sepal；Base portion light green, middle part purple, top are white
Color, June at florescence, fruiting period November.Passion fruit mainly has purple fruit and the major class of yellow fruit two.Fruit is berry, avette, indulges 5~7cm of footpath,
4~6cm of transverse diameter, young fruit green, mellow fruit purple, 60~120g of single fruit weight, shell is tough and tensile, and pulp yellow, internal seeds are darkly
Color, average 60~100 pieces/fruit.Pericarp keratin is tough and tensile, smooth.Yellow fruit juice is full of between pulp, like raw egg yolk.Juice content
40% or so, process crushing juice rate 28% to 33%.Passion fruit fruit is ripe December, needs the old name for the Arabian countries in the Middle East of after-ripening 4 to 7 edible after harvesting
With.
According to scientific forecasting, passion fruit contains very abundant natural Vitamin C, just contains Vitamin C in every 100 grams of fruit juice
For 34.6 milligrams, also rich in dimension life A, B1, B2 etc., also contain materials such as abundant calcium, phosphorus, iron and several amino acids and micro- in addition
Secondary element.
Meanwhile passion fruit is red rich in organic acid, niacin, amino acid, linoleic acid, mineral matter, β-carrotene, tomato
The kind more than 160 such as element, soluble dietary fiber, alkaloid, flavonoids beneficiating ingredient needed by human, be health care, medical value very
A kind of high natural food.
Tartaric acid, dietary fiber contained by passion fruit, act on digestive system, to poor appetite, gasteremphraxis, the effect of constipation all
Very well.
Passion fruit contains vitamin E, lycopene, and the effect to reproductive system can't neglect, in many many nights many urines
After designed for old people, the number for feeling to get up at night significantly reduces, therefore passion fruit has saying for enriching yin and nourishing kidney.
There are 165 kinds of compounds in passion fruit fruit juice, constitute peat-reek.Often feeding passion fruit, which has, to refresh the mind, supports
Face beauty, promote the production of body fluid to quench thirst, help digest, preventing phlegm from forming and stopping coughing, relief of constipation, promoting blood circulation, improve immune function of human body, enriching yin mend
The effect of kidney, dispelling fatigue, hypertension and hyperlipemia, anti-aging, anti-hypertension.Root, stem, the leaf of passion fruit have anti-inflammatory analgetic, lipid-loweringing
Decompression and other effects.
Ancient prescription dietary therapy of Chinese medicine professional person introduces：Natural passion fruit Central nervous system has the function that complexity, has
Comprehensive psychosis effect.Can be releived anxiety and tense, depressed joyless, nervous caused headache.Fruit juice, which has, to promote the production of body fluid only
Yearningly, refresh the mind, help digest, preventing phlegm from forming and stopping coughing, controlling deficiency of the kidney and the function of nourishing and fit keeping function.Root, stem, the leaf of passion fruit can enter
Medicine, there are anti-inflammatory analgetic, promoting blood circulation, also enriching yin and nourishing kidney, the curative effect such as blood fat-reducing blood pressure-decreasing.The superfluorescent fiber of passion fruit can promote to arrange
Let out, relief of constipation symptom, remove the excitor substance for sticking and being trapped in enteron aisle, avoid stimulating enteron aisle and reabsorbed by human body, so as to
The illness rate of colon cancer is reduced, superfluorescent fiber also has antitumor activity.VC in passion fruit participates in cholesterol metabolic, can reduce courage
Sterol, purify blood.In addition, the VC being rich in passion fruit, carrotene, SOD enzymes can remove interior free yl, play beauty treatment and resist
Aging acts on.
Passion fruit is natural tranquillizer, has relaxation, the effect of calming nerves；Insomnia can be treated, induction nature enters
Sleep and deep sleep, eliminate headache, it is dizzy phenomena such as；Can also be releived anxiety and tense, depressed joyless, nervous caused head
Bitterly, all senses of discomfort such as stomachache, frequent micturition, nervous, muscle cramp, twitch, pain.
At present, in the market is more as the lozenge of raw material using passion fruit, but many problems, such as Application No. also be present
CN201710054087.4 a kind of passion fruit lozenge and preparation method thereof, the method discloses a kind of passion fruit lozenge, to hundred
The extraction of fragrant fruit uses traditional water extraction mode, and this rough machining method inevitably causes nutrition and active ingredient passion fruit
The loss of seed oil, while there is the materials such as the flavones of therapeutic effect, polysaccharide to cause curative effect not because the content extracted is not high
It is enough notable, and taken in the lozenge added with the non-active ingredients such as auxiliary material, flavor enhancement, lubricant and chemical addition agent, people
Also a certain amount of additive has been taken while lozenge, has not met requirement of the people to green and healthy life.
On the other hand, it is more as the product health-care efficacy exploitation of primary raw material using passion fruit, such as Application No.
A kind of hypoglycemic passion fruit lozenges of CN201610869658.5, a kind of hypotensive passion fruit lozenges of CN201610869657.0,
CN201610869645.8 is a kind of to improve immune passion fruit lozenge, and a kind of clearing heat and detoxicating passion fruits of CN201610869656.6 contain
Piece, but the passion fruit pure plant lozenge with treatment sphagitis effect does not have been reported that also.
【The content of the invention】
In order to solve the above-mentioned technical problem, the present invention provide it is a kind of it is pure natural, without chemical addition agent, in good taste and with association
The passion fruit seed oil lozenge of same sex treatment sphagitis effect；Using the inventive method, passion fruit raw material availability is high, technique letter
List, production cost are low.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of passion fruit seed oil lozenge, is made up of following components ratio by weight：10~20 parts of passion fruit seed oil, hundred perfume
20~65 parts of berry extract, 25~65 parts of gorgon euryale seed powder.
Further, the passion fruit seed oil and passion fruit extract are prepared by following methods step：
A. the preparation of passion fruit seed oil：The fresh seed of passion fruit is taken out, dries, dry, crushes as passion fruit seed powder, is placed in
Extract, separate in supercritical carbon dioxide extracting kettle, produce passion fruit seed oil；
B. the preparation of passion fruit extract：Remaining part is through smashing to pieces after step A passion fruit takes out fresh seed, then
Add the ethanol solution that volume fraction is 60~80% to be completely soaked, extracted using ultrasonic-microwave combined method, extract solution recovery second
Alcohol, dry, produce passion fruit extract；Active ingredient accounts for the percentage by weight of extract gross weight in the passion fruit extract
For：General flavone 30~40%, polysaccharide 30~50%, wherein total acid 5~12%, three's percentage by weight sum are less than 100%.
Further, in step A, the extracting pressure of the supercritical carbon dioxide extracting is 30~35Mpa, extraction temperature
For 35~40 DEG C, separating pressure is 5~6Mpa, and separation temperature is 40~45 DEG C.
Further, in step B, it is 40~400W that the ultrasonic-microwave combined method, which is extracted as in ultrasonic power, microwave
Power is 400~2000W, is extracted 20~30 minutes under the conditions of 45~50 DEG C.
Further, in step B, the drying is：It is aqueous to passion fruit extract using vacuum drying or spray drying
Amount is below 5%.
Further, described passion fruit seed oil lozenge, the gorgon euryale seed powder are that the Gorgon fruit that Gorgon fruit obtains through ultramicro grinding surpasses
Micro mist.
A kind of method for preparing passion fruit seed oil lozenge of the present invention, comprises the following steps：
1) passion fruit seed oil is dissolved with appropriate volume fraction for 75~85% ethanol, obtains passion fruit seed oil solution；
2) part gorgon euryale seed powder is taken, is rushed and starched with hot water, the adhesive of mass concentration 5~35% is made；
3) take the passion fruit extract after the gorgon euryale seed powder for not rushing slurry and crushing to mix, add step 2) adhesive be made it is soft
Material, softwood are placed in granulator and pelletized, and obtain passion fruit seed oil lozenge particle；
4) the passion fruit seed oil lozenge particle of step 3) is dried to water content below 5%, uniformly sprays into step 1)
Passion fruit seed oil solution, is always mixed even, is placed in tablet press machine and carries out tabletting, obtains passion fruit seed oil lozenge.
Further, in step 2), the hot water temperature is 90~100 degree.
The present invention also provides above-mentioned passion fruit seed oil lozenge and is preparing the application in treating sphagitis medicine.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
(1) present invention obtains passion fruit seed oil using supercritical carbon dioxide extraction passion fruit seed, and remainder is in ultrasound
Microwave is extracted act on simultaneously under with ethanol so that the active ingredient of passion fruit is fully extracted out, improves passion fruit raw material
Recovery rate and utilization rate, avoid waste.
(2) the passion fruit extract that the present invention is extracted in the case where ultrasonic-microwave acts on simultaneously with ethanol has multiple action and work(
Imitate, general flavone, polysaccharide and the total acid in extract do active ingredient in lozenge；Polysaccharide also makees sweetener simultaneously, total acid makees acid
Taste agent so that lozenge is sour-sweet tasty and refreshing, suitable for people of all ages.
(3) present invention gorgon euryale seed powder is added in lozenge, one side Gorgon fruit be rich in starch, can as lozenge filler with
Adhesive；On the other hand Gorgon fruit and passion fruit seed oil, passion fruit extract produce synergy under certain proportion, improve this
Invention lozenge treats the effect of sphagitis.
(4) present invention had both improved made pellet viscosity, reached again without auxiliary material by the use of gorgon euryale seed powder punching slurry as adhesive
The effect of composition addition, compared with general technology, the made lozenge effective ingredient of the inventive method is high, and nutritive value is good, prevents
Other auxiliary material compositions reduce the possibility of lozenge effects, while avoid the harm of additive, green and healthy, more meet people
To the demand of healthy living.
(5) raw material that the present invention uses is taken from " integration of drinking and medicinal herbs " kind among the people, without any side effects, safe to use.
(6) active ingredient of passion fruit and Gorgon fruit is passed through the mucous membrane in oral cavity or esophagus by the present invention with buccal tablet formulation
Absorb, avoid active ingredient by caused loss during the absorbed organs such as human intestines and stomach and liver, improve pharmaceutical compositions
Absorption rate, bioavilability significantly improves than ordinary preparation, realize it is quick, convenient, purpose is efficiently administered.
(7) simple production process of the present invention, it is adapted to industrialized production.
【Embodiment】
Embodiment 1
A kind of passion fruit seed oil lozenge, is made up of following components ratio by weight：10 parts of passion fruit seed oil, passion fruit carry
Take 65 parts of thing, 25 parts of Gorgon fruit Ultramicro-powder.
Wherein passion fruit seed oil and passion fruit extract are prepared by following methods step：
A. the preparation of passion fruit seed oil：The fresh seed of passion fruit is taken out, dries, dry, crushes as passion fruit seed powder, is placed in
It is 30~35Mpa in extracting pressure in supercritical carbon dioxide extracting kettle, extraction temperature is 35~40 DEG C, separating pressure is 5~
6Mpa, separation temperature are extract and separate at 40~45 DEG C, produce passion fruit seed oil；
B. the preparation of passion fruit extract：Remaining part is through smashing to pieces after step A passion fruit takes out fresh seed, then
Add the ethanol solution that volume fraction is 60% to be completely soaked, be 40W in ultrasonic power using ultrasonic-microwave combined method, it is micro-
Wave power is 400W, is extracted 20 minutes under the conditions of 45~50 DEG C, extract solution recovery ethanol, dries, produces passion fruit extract；
The percentage by weight that wherein active ingredient accounts for extract gross weight in passion fruit extract is：General flavone 30% is more
Sugar 50%, total acid 5%；
The detection method of passion fruit extract of the present invention is as follows：
(1) content detection of general flavone：By SN/T4592-2016 standard tests；
(2) content detection of polysaccharide：By SN/T4260-2015 standard tests；
(3) content detection of total acid：By GB/T12456-2008 standard tests；
A kind of method for the passion fruit seed oil lozenge for preparing the present invention, comprises the following steps：
1) passion fruit seed oil is dissolved with 75% appropriate ethanol, obtains passion fruit seed oil solution；
2) the 1/10 of Gorgon fruit Ultramicro-powder is taken, slurry is rushed with 90~100 degree of hot water, the adhesive of mass concentration 5% is made；
3) the passion fruit extract mixing after taking the Gorgon fruit Ultramicro-powder for not rushing slurry and crushing, the adhesive system of step 2) is added
Into softwood, softwood is placed in granulator and pelletized, and obtains passion fruit seed oil lozenge particle；
4) the passion fruit seed oil lozenge particle of step 3) is dried to water content below 5%, uniformly sprays into step 1)
Passion fruit seed oil solution, is always mixed even, is placed in tablet press machine and carries out tabletting, obtains passion fruit seed oil lozenge.
Embodiment 2
A kind of passion fruit seed oil lozenge, is made up of following components ratio by weight：20 parts of passion fruit seed oil, passion fruit carry
Take 30 parts of thing, 50 parts of Gorgon fruit Ultramicro-powder.
Wherein passion fruit seed oil and passion fruit extract are prepared by following methods step：
A. the preparation of passion fruit seed oil：The fresh seed of passion fruit is taken out, dries, dry, crushes as passion fruit seed powder, is placed in
It is 30~35Mpa in extracting pressure in supercritical carbon dioxide extracting kettle, extraction temperature is 35~40 DEG C, separating pressure is 5~
6Mpa, separation temperature are extract and separate at 40~45 DEG C, produce passion fruit seed oil；
B. the preparation of passion fruit extract：Remaining part is through smashing to pieces after step A passion fruit takes out fresh seed, then
Add the ethanol solution that volume fraction is 80% to be completely soaked, be 400W in ultrasonic power using ultrasonic-microwave combined method, it is micro-
Wave power is 2000W, is extracted 30 minutes under the conditions of 45~50 DEG C, extract solution recovery ethanol, dries, produces passion fruit extract；
The percentage by weight that wherein active ingredient accounts for extract gross weight in passion fruit extract is：General flavone 40% is more
Sugar 30%, total acid 12%；
The detection method of passion fruit extract of the present invention is as follows：
(1) content detection of general flavone：By SN/T4592-2016 standard tests；
(2) content detection of polysaccharide：By SN/T4260-2015 standard tests；
(3) content detection of total acid：By GB/T12456-2008 standard tests；
A kind of method for the passion fruit seed oil lozenge for preparing the present invention, comprises the following steps：
1) passion fruit seed oil is dissolved with 85% appropriate ethanol, obtains passion fruit seed oil solution；
2) the 1/2 of Gorgon fruit Ultramicro-powder is taken, slurry is rushed with 90~100 degree of hot water, the adhesive of mass concentration 35% is made；
3) the passion fruit extract mixing after taking the Gorgon fruit Ultramicro-powder for not rushing slurry and crushing, the adhesive system of step 2) is added
Into softwood, softwood is placed in granulator and pelletized, and obtains passion fruit seed oil lozenge particle；
4) the passion fruit seed oil lozenge particle of step 3) is dried to water content below 5%, uniformly sprays into step 1)
Passion fruit seed oil solution, is always mixed even, is placed in tablet press machine and carries out tabletting, obtains passion fruit seed oil lozenge.
Embodiment 3
A kind of passion fruit seed oil lozenge, is made up of following components ratio by weight：15 parts of passion fruit seed oil, passion fruit carry
Take 20 parts of thing, 65 parts of Gorgon fruit Ultramicro-powder.
Wherein passion fruit seed oil and passion fruit extract are prepared by following methods step：
A. the preparation of passion fruit seed oil：The fresh seed of passion fruit is taken out, dries, dry, crushes as passion fruit seed powder, is placed in
It is 30~35Mpa in extracting pressure in supercritical carbon dioxide extracting kettle, extraction temperature is 35~40 DEG C, separating pressure is 5~
6Mpa, separation temperature are extract and separate at 40~45 DEG C, produce passion fruit seed oil；
B. the preparation of passion fruit extract：Remaining part is through smashing to pieces after step A passion fruit takes out fresh seed, then
Add the ethanol solution that volume fraction is 70% to be completely soaked, be 200W in ultrasonic power using ultrasonic-microwave combined method, it is micro-
Wave power is 1000W, is extracted 25 minutes under the conditions of 45~50 DEG C, extract solution recovery ethanol, dries, produces passion fruit extract；
The percentage by weight that wherein active ingredient accounts for extract gross weight in passion fruit extract is：General flavone 35% is more
Sugar 42%, total acid 9%；
The detection method of passion fruit extract of the present invention is as follows：
(1) content detection of general flavone：By SN/T4592-2016 standard tests；
(2) content detection of polysaccharide：By SN/T4260-2015 standard tests；
(3) content detection of total acid：By GB/T12456-2008 standard tests；
A kind of method for the passion fruit seed oil lozenge for preparing the present invention, comprises the following steps：
1) passion fruit seed oil is dissolved with 80% appropriate ethanol, obtains passion fruit seed oil solution；
2) the 1/3 of Gorgon fruit Ultramicro-powder is taken, slurry is rushed with 90~100 degree of hot water, the adhesive of mass concentration 20% is made；
3) the passion fruit extract mixing after taking the Gorgon fruit Ultramicro-powder for not rushing slurry and crushing, the adhesive system of step 2) is added
Into softwood, softwood is placed in granulator and pelletized, and obtains passion fruit seed oil lozenge particle；
4) the passion fruit seed oil lozenge particle of step 3) is dried to water content below 5%, uniformly sprays into step 1)
Passion fruit seed oil solution, is always mixed even, is placed in tablet press machine and carries out tabletting, obtains passion fruit seed oil lozenge.
Comparative example 1
The passion fruit seed oil lozenge of comparative example 1, is made up of by weight percentage following component：Passion fruit seed oil 20%,
Gorgon euryale seed powder 35%, remaining is starch.
Comparative example 2
The passion fruit seed oil lozenge of comparative example 2, is made up of by weight percentage following component：Passion fruit extract
65%th, gorgon euryale seed powder 35%.
Comparative example 3
The passion fruit seed oil lozenge of comparative example 3, is made up of by weight percentage following component：Passion fruit seed oil 20%,
Passion fruit extract 65%, remaining is starch.
Comparative example 4
The passion fruit seed oil lozenge of comparative example 4, formed by 100% gorgon euryale seed powder compacting.
The effect of test example passion fruit seed oil lozenge of the present invention is to sphagitis
1st, general information：
700 cases are randomly divided into 7 groups, every group 100, age 24-57 year, average age is 37 years old, meet with
Lower diagnostic criteria：Pharyngeal pain, discomfort is dried, there is foreign body sensation, burning heat sensation, the hyperemia of pharyngeal mucosa diffusivity；700 through above disappearing
Change road x-ray barivm meal fluoroscopy (screem) or fibergastroscopy no abnormality seen.
2nd, medicine：Embodiment 1~3, comparative example 1~4.
3rd, treatment method：
Treated using the passion fruit seed oil lozenge in the present embodiment 1~3 and comparative example 1~4, wherein one day three
Secondary, 1 tablet once, every 0.5g, and it is a course for the treatment of to treat 3 months.
4th, criterion of therapeutical effect：
It is effective：Pharyngalgia, dry, scorching hot, foreign body sensation disappear, and pharyngeal mucosa is congested without obvious diffusivity；
Effectively：Pharyngalgia, dry, scorching hot, foreign body sensation substantially mitigate, and diffusivity that pharyngeal mucosa is slight is congested；
It is invalid：Pharyngalgia, dry, scorching hot, foreign body sensation mitigate without obvious, and pharyngeal mucosa is still congested in diffusivity.
5th, result of the test
The effect of 1 embodiment of table, 1~3 pair for the treatment of sphagitis
| Group | It is effective | Effectively | It is invalid | Total effective rate |
| Embodiment 1 | 85 | 11 | 4 | 96.0% |
| Embodiment 2 | 91 | 5 | 4 | 96.0% |
| Embodiment 3 | 89 | 11 | 0 | 100.0% |
| Comparative example 1 | 32 | 8 | 60 | 40.0% |
| Comparative example 2 | 29 | 7 | 64 | 36.0% |
| Comparative example 3 | 36 | 10 | 54 | 46.0% |
| Comparative example 4 | 21 | 5 | 74 | 26.0% |
As it can be seen from table 1 the significant effect of 1~3 pair for the treatment of sphagitis of embodiment, effective percentage reach more than 96.0%,
Illustrate that Gorgon fruit and passion fruit seed oil, passion fruit extract produce synergistic therapeutic action under certain proportion, during medication, do not find
There are any toxic side effect, drug safety.
Described above is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair
Bright patent claim, the equal change completed or modification change under the technical spirit suggested by all present invention, all should belong to
Cover the scope of the claims in the present invention.
Claims (9)
1. a kind of passion fruit seed oil lozenge, it is characterised in that be made up of following components ratio by weight：Passion fruit seed oil 10~
20 parts, 20~65 parts of passion fruit extract, 25~65 parts of gorgon euryale seed powder.
2. passion fruit seed oil lozenge as claimed in claim 1, it is characterised in that passion fruit seed oil and passion fruit extract by
It is prepared by following methods step：
A. the preparation of passion fruit seed oil：The fresh seed of passion fruit is taken out, dries, dry, is crushed as passion fruit seed powder, is placed in super face
Extract, separate in boundary's carbon dioxide abstraction kettle, produce passion fruit seed oil；
B. the preparation of passion fruit extract：After step A passion fruit takes out fresh seed then remaining part adds through smashing to pieces
The ethanol solution that volume fraction is 60~80% is completely soaked, and is extracted using ultrasonic-microwave combined method, extract solution recovery ethanol, is done
It is dry, produce passion fruit extract；The percentage by weight that active ingredient accounts for extract gross weight in the passion fruit extract is：Always
Flavones 30~40%, polysaccharide 30~50%, wherein total acid 5~12%, three's percentage by weight sum are less than 100%.
3. passion fruit seed oil lozenge as claimed in claim 2, it is characterised in that in step A, the supercritical carbon dioxide extracting
Extracting pressure be 30~35Mpa, extraction temperature is 35~40 DEG C, and separating pressure be 5~6Mpa, and separation temperature is 40~45
℃。
4. passion fruit seed oil lozenge as claimed in claim 2, it is characterised in that in step B, the ultrasonic-microwave combined method extraction
To be 40~400W in ultrasonic power, microwave power is 400~2000W, is extracted 20~30 minutes under the conditions of 45~50 DEG C.
5. passion fruit seed oil lozenge as claimed in claim 2, it is characterised in that in step B, the drying is：Done using vacuum
Dry or spray drying is to passion fruit extract water content below 5%.
6. passion fruit seed oil lozenge as claimed in claim 1, it is characterised in that：The gorgon euryale seed powder is that Gorgon fruit obtains through ultramicro grinding
The Gorgon fruit Ultramicro-powder obtained.
A kind of 7. method for preparing any one of the claim 1~6 passion fruit seed oil lozenge, it is characterised in that including following step
Suddenly：
1) passion fruit seed oil is dissolved with appropriate volume fraction for 75~85% ethanol, obtains passion fruit seed oil solution；
2) part gorgon euryale seed powder is taken, is rushed and starched with hot water, the adhesive of mass concentration 5~35% is made；
3) the passion fruit extract after the gorgon euryale seed powder for not rushing slurry and crushing is taken to mix, softwood is made in the adhesive for adding step 2),
Softwood is placed in granulator and pelletized, and obtains passion fruit seed oil lozenge particle；
4) the passion fruit seed oil lozenge particle of step 3) is dried to water content below 5%, uniformly spray into step 1) hundred are fragrant
Fruit seed oil solution, always it is mixed even, is placed in tablet press machine and carries out tabletting, obtains passion fruit seed oil lozenge.
8. the method as claimed in claim 1 for preparing passion fruit seed oil lozenge, it is characterised in that：In step 2), the hot water
Temperature is 90~100 degree.
9. any one of the claim 1~6 passion fruit seed oil lozenge is preparing the application in treating sphagitis medicine.
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| CN201710599893.XA CN107412345A (en) | 2017-07-21 | 2017-07-21 | A kind of passion fruit seed oil lozenge and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272063A (en) * | 2018-01-31 | 2018-07-13 | 袁承淼 | A flavor-enhancing process of passion fruit juice |
| CN111406860A (en) * | 2020-04-27 | 2020-07-14 | 广东金妮宝科技发展有限公司 | Passion fruit sauce and preparation method thereof |
| CN113575943A (en) * | 2021-06-25 | 2021-11-02 | 广州泽力医药科技有限公司 | Method for extracting lycopene and related active ingredients from passion fruit |
-
2017
- 2017-07-21 CN CN201710599893.XA patent/CN107412345A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272063A (en) * | 2018-01-31 | 2018-07-13 | 袁承淼 | A flavor-enhancing process of passion fruit juice |
| CN111406860A (en) * | 2020-04-27 | 2020-07-14 | 广东金妮宝科技发展有限公司 | Passion fruit sauce and preparation method thereof |
| CN113575943A (en) * | 2021-06-25 | 2021-11-02 | 广州泽力医药科技有限公司 | Method for extracting lycopene and related active ingredients from passion fruit |
| CN113575943B (en) * | 2021-06-25 | 2023-12-26 | 广州泽力医药科技有限公司 | Extraction method of lycopene and related active ingredients in passion fruits |
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Application publication date: 20171201 |