CN107412295A - A kind of apocynum venetum health care tea and preparation method thereof - Google Patents
A kind of apocynum venetum health care tea and preparation method thereof Download PDFInfo
- Publication number
- CN107412295A CN107412295A CN201710276934.1A CN201710276934A CN107412295A CN 107412295 A CN107412295 A CN 107412295A CN 201710276934 A CN201710276934 A CN 201710276934A CN 107412295 A CN107412295 A CN 107412295A
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- CN
- China
- Prior art keywords
- bluish dogbane
- health care
- volatile oil
- apocynum venetum
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/06—Treating tea before extraction; Preparations produced thereby
- A23F3/14—Tea preparations, e.g. using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a kind of apocynum venetum health care tea and preparation method thereof, is related to medicines and health protection field.The constituent of the apocynum venetum health care tea count in parts by weight including：10~30 parts of 10~30 parts of bluish dogbane water extract and bluish dogbane extractive of volatile oil.Apocynum venetum health care tea adds bluish dogbane extractive of volatile oil in bluish dogbane water extract, takes full advantage of the active ingredient in Folium Apocyni Veneti, can have healthcare function to hypertension, high fat of blood, chemical damage simultaneously.In addition, the preparation method of above-mentioned apocynum venetum health care tea provided in an embodiment of the present invention, including：Folium Apocyni Veneti is extracted through water, decocting liquid is collected and prepares bluish dogbane water extract；The oil water mixture for collecting volatile oil and steam simultaneously prepares bluish dogbane extractive of volatile oil；And mixed according to the parts by weight of above-mentioned constituent.Using an extraction process, different extracts is collected respectively, has saved production cost, while also add the recovery rate of the active ingredient of Folium Apocyni Veneti.
Description
Technical field
The present invention relates to medicines and health protection field, in particular to a kind of apocynum venetum health care tea and preparation method thereof.
Background technology
With the development of society, people life style and eating habit, there occurs huge change, the thing followed is high
Blood pressure, hyperlipemic patients are continuously increased, and are constantly deteriorated along with surrounding environment, chemical damage is also threaten people
Health.In order to adapt to the needs in market, convenient to take, safe health protection tea more and more welcomed by the people.Spread out at present
Ramie product and patent are mostly hypertension, high fat of blood class product, seldom refer to injury of the chemical damage to human body.Majority is spreaded out
Numb tea product constituent is tealeaves, and its active ingredient dissolution rate is slow, and health-care effect is undesirable.
The content of the invention
It is an object of the invention to provide a kind of apocynum venetum health care tea, and its mobility is preferable, and active ingredient rate of release is more
It hurry up, health-care effect is more obvious.
Another object of the present invention is to provide a kind of preparation method of apocynum venetum health care tea, the preparation method is combined and spreaded out
The specificity of numb health protection tea, takes full advantage of Folium Apocyni Veneti, and the effect and effect for making Folium Apocyni Veneti more effectively play, so that
Obtained apocynum venetum health care tea health-care effect is more obvious.
What embodiments of the invention were realized in：
The embodiments of the invention provide a kind of apocynum venetum health care tea, its constituent count in parts by weight including：Bluish dogbane
10~30 parts of 10~30 parts of water extract and bluish dogbane extractive of volatile oil.
Further, in a preferred embodiment of the invention, the constituent of above-mentioned apocynum venetum health care tea is in parts by weight
Meter also includes：20~300 parts of green tea powder.
Further, in a preferred embodiment of the invention, polyphenol content >=40% of above-mentioned apocynum venetum health care tea, have
Effective component content general flavone >=5%, Determination of Hyperoside >=1%.
The embodiment of the present invention additionally provides a kind of preparation method of apocynum venetum health care tea, including：By Folium Apocyni Veneti through water extraction
Take, collect decocting liquid and prepare bluish dogbane water extract；The oil water mixture for collecting volatile oil and steam simultaneously prepares bluish dogbane volatilization
Oil extract；And in parts by weight, by 10~30 parts of bluish dogbane water extract and bluish dogbane extractive of volatile oil 10~30
Part mixing.
Further, in a preferred embodiment of the invention, above-mentioned oil water mixture preparation bluish dogbane volatile oil is collected to carry
Thing is taken to include：Emulsification embedding medium is added into oil water mixture, is spray-dried again after forming emulsion；Wherein, embedding medium is emulsified
Including casein-sodium, dextrin, sucrose ester and monoglyceride.
Further, in a preferred embodiment of the invention, into above-mentioned oil water mixture add emulsification embedding dosage form into
Emulsion includes：Casein-sodium, dextrin and sucrose ester are dissolved in water, stirring is warming up to 60~80 DEG C of formation aqueous phases；By profit
After mixture and monoglyceride mixing, stirring is warming up to 50~70 DEG C of formation oil phases；Aqueous phase and oil phase are mixed, keeping temperature in
50~70 DEG C, 15min is stirred, forms two-phase mixtures liquid, and by homogeneous after two-phase mixtures liquid emulsification pretreatment, forms emulsion.
Further, in a preferred embodiment of the invention, be spray-dried above-mentioned emulsion be EAT 180~
200 DEG C, 80~100 DEG C of leaving air temp, carry out under conditions of 5~10kPa of pressure.
Further, in a preferred embodiment of the invention, bluish dogbane water extract and bluish dogbane extractive of volatile oil are mixed
Including：It is first 1 in mass ratio by bluish dogbane extractive of volatile oil and ethanol:2 ratio is well mixed, and then bluish dogbane is volatilized
The mixture of oil extract and ethanol is uniformly sprayed into bluish dogbane water extract, is sealed.
Further, in a preferred embodiment of the invention, the constituent of apocynum venetum health care tea is counted also in parts by weight
Including：20~300 parts of green tea powder；Sprayed into bluish dogbane water extract bluish dogbane extractive of volatile oil and ethanol mixture it
Before, first bluish dogbane water extract is mixed with green tea powder, mixing bluish dogbane water extract and green tea powder includes：Bluish dogbane water extract is passed through
Mixed after spray drying with green tea powder；Or bluish dogbane water extract is sprayed onto in green tea powder, mixing granulation.
Further, in a preferred embodiment of the invention, before water extracts Folium Apocyni Veneti, first Folium Apocyni Veneti is utilized
Complex enzyme formulation digests, and the weight of complex enzyme formulation is the 0.03~0.08% of Folium Apocyni Veneti weight；Complex enzyme formulation is by weight
Percentages include：Protease：Cellulase：Pectase=1：1：1.
The beneficial effect of the embodiment of the present invention is：
Apocynum venetum health care tea provided in an embodiment of the present invention combines bluish dogbane water extract and bluish dogbane extractive of volatile oil,
The active ingredient in Folium Apocyni Veneti is taken full advantage of, there can be health care work(to hypertension, high fat of blood, chemical damage simultaneously
Can, bluish dogbane volatile oil is added in bluish dogbane water extract, the hepatoprotective effect of apocynum venetum health care tea is more obvious.Bluish dogbane health care
Bluish dogbane extractive of volatile oil in tea makes full use of its active ingredient, extensive to the development and application values of bluish dogbane.
In addition, the preparation method of the apocynum venetum health care tea provided in the present embodiment, decocting liquid is collected by water extraction respectively
And oil water mixture, and bluish dogbane water extract and bluish dogbane extractive of volatile oil are prepared respectively, utilize an extraction process, difference
Different extracts is collected, the active ingredient of Folium Apocyni Veneti is fully utilized, production cost has been saved, also add simultaneously
The recovery rate of the active ingredient of Folium Apocyni Veneti, obtained apocynum venetum health care tea is not only only preferably water-soluble, at the same also have compared with
Good fat-soluble, the dissolving of its active ingredient and good fluidity, work rapid.
Brief description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below by embodiment it is required use it is attached
Figure is briefly described, it will be appreciated that the following drawings illustrate only certain embodiments of the present invention, therefore be not construed as pair
The restriction of scope, for those of ordinary skill in the art, on the premise of not paying creative work, can also be according to this
A little accompanying drawings obtain other related accompanying drawings.
Fig. 1 is the various preparation dissolution experimental result comparison diagrams of bluish dogbane that experimental example two of the present invention provides.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products that can be obtained by commercially available purchase.
Apocynum venetum health care tea of the embodiment of the present invention and preparation method thereof is specifically described below.
Apocynum venetum health care tea is using the extract of Folium Apocyni Veneti as main component, and bluish dogbane has lowering blood pressure and blood fat, stopped
Cough resolving sputum, diuresis anti-inflammatory, heat-clearing and fire-reducing, suppressing hyperactive liver for calming endogenous wind, improve sleep, anti-aging, anti-melancholy, improvement human body respiration and disappear
Change, treatment is had a dizzy spell with edema and other effects.Research about Folium Apocyni Veneti is more, but for the research of Folium Apocyni Veneti volatile oil
It is less, its volatile oil component is studied, but the effect of volatile oil and its act on research at present seldom.
The apocynum venetum health care tea provided in the present embodiment be by Folium Apocyni Veneti water extract and extractive of volatile oil compounding and
Into it has the effect of lowering blood pressure and blood fat, auxiliary protection chemical damage.
In the present embodiment, the profit that Folium Apocyni Veneti is collected to decocting liquid and volatile oil and steam respectively after water extracts mixes
Compound, bluish dogbane water extract is prepared using decocting liquid, while bluish dogbane extractive of volatile oil is prepared using oil water mixture.Then
Using bluish dogbane water extract and bluish dogbane extractive of volatile oil as constituent, after mixing according to a certain percentage, this implementation is produced
The apocynum venetum health care tea provided in example.Bluish dogbane water extract and bluish dogbane extractive of volatile oil can mix in any proportion, tool
Into the present embodiment, the constituent of apocynum venetum health care tea is counted in parts by weight to be mixed body, wherein, bluish dogbane water extract 10
~30 parts and 10~30 parts of bluish dogbane extractive of volatile oil.
Further, in the present embodiment, the constituent of apocynum venetum health care tea is counted can also include in parts by weight：Green tea
20~300 parts of powder.
Green tea powder is a kind of green tea of ultra micro powdery, and green tea powder has good anti-oxidant and sedation, can mitigated tired
Labor.Contain vitamin C and flavonoids in green tea, flavonoids therein can strengthen the anti-oxidation efficacy of Vitamin C, and green tea powder can
Lipid-loweringing, diuresis recover from fatigue, help to suppress angiocardiopathy.The addition of green tea powder so that the mouthfeel of apocynum venetum health care tea is more preferably.
Folium Apocyni Veneti water extract has protection to the mouse liver injury caused by carbon tetrachloride or D-galactosamine or lipopolysaccharides
Effect；The IC50 of wherein flavonol glycosides is relatively low, and the IC50 classes of catechin are higher, but after being substituted by phenylpropyl alcohol ketone group, activity is again
Enhancing, it is the principle active component that Folium Apocyni Veneti plays Hepatocyte protection therefore, in the present embodiment to think flavonol glycosides.So we
Quality control index is used as using general flavone, Hyperoside.
Polyphenol content >=40%, active constituent content general flavone in the apocynum venetum health care tea provided in the present embodiment >=
5%th, Determination of Hyperoside >=1%.
The preparation method of above-mentioned apocynum venetum health care tea is additionally provided in the embodiment of the present invention, it includes：
S100, water extraction step：Folium Apocyni Veneti is extracted through water, collects decocting liquid, while collects volatile oil and steam
Oil water mixture.
S101：Add complex enzyme formulation.
Before Folium Apocyni Veneti is carried out into water extraction, first Folium Apocyni Veneti is soaked, and added into Folium Apocyni Veneti
Enter complex enzyme formulation, digest Folium Apocyni Veneti, the active ingredient of Folium Apocyni Veneti is easier to be dissolved in the water.It is multiple in the present embodiment
The addition of synthase preparation is the 0.05% of Folium Apocyni Veneti addition, and the complex enzyme formulation is by protease, cellulase
It is 1 by weight with pectase：1：1 proportioning mixes.
Because the cell membrane composition of Folium Apocyni Veneti is cellulose and pectin, and the composition of cell membrane be phospholipid bilayer and
Protein, it is 1 according to weight ratio before water extracts Folium Apocyni Veneti in the present embodiment：1：1 proportioning adds protease, fiber
Plain enzyme and pectase, enable protease that the protein in Folium Apocyni Veneti is hydrolyzed into polypeptide, and cellulase can hydrolyze sieve
Cellulose in cloth sesame slices, pectase can hydrolyze the pectin in Folium Apocyni Veneti, disintegrate the cell membrane and intercellular layer of Folium Apocyni Veneti,
So that the active principle in Folium Apocyni Veneti quickly can be dissolved into water, the efficiency of water extraction is improved.
S102：Collect decocting liquid and oil water mixture.
The Folium Apocyni Veneti after soaking is taken, is soaked to Folium Apocyni Veneti, the amount for adding water is the volume of Folium Apocyni Veneti
10~12 times, 90~100 DEG C decoct three times, each 1h, merge collect bluish dogbane decocting liquid.Evaporation gained is collected simultaneously
The oil water mixture that volatile oil and steam are formed.
S200, prepare bluish dogbane water extract：By decocting liquid in 60 DEG C, it is concentrated under reduced pressure under conditions of -0.1Mpa, adds ethanol extremely
The mass percent that ethanol in decocting liquid accounts for decocting liquid is 40%~60%, stirs, stands overnight, and is filtered, and collects filter
Liquid, then be concentrated under reduced pressure, the concentrate of bluish dogbane decocting liquid is obtained, that is to say bluish dogbane water extract.In the present embodiment, using water extracting alcohol
Heavy method refines to decocting liquid, and in the first time concentrate of decocting liquid, adding ethanol makes decocting liquid up to 40%~60%
Alcohol content so that the active ingredient in bluish dogbane dissolves in alcoholic solution, enables water extract to refine after separation of solid and liquid.
S300, prepare bluish dogbane extractive of volatile oil：Emulsification embedding medium is added into oil water mixture, forms emulsion
Afterwards, then it is spray-dried.
Specifically, emulsification embedding medium includes casein-sodium, dextrin, sucrose ester and monoglyceride.Dextrin can be selected from pyrolysis
One or more in dextrin, maltodextrin and beta-schardinger dextrin, in the present embodiment, preferably dextrin is selected from maltodextrin and β-ring paste
One of essence.
Casein-sodium, dextrin, sucrose ester and monoglyceride mix as emulsification embedding medium and not all add together with profit
Compound mixes, and in the present embodiment, step S300 preparation bluish dogbane extractive of volatile oil specifically includes：
S301：The preparation of aqueous phase.
Casein-sodium, dextrin and sucrose ester are put into aqueous phase tank, are dissolved in water, stirring is warming up to 60~80 DEG C, material
Dissolving forms aqueous phase.Wherein, the mass percent that the addition of water accounts for emulsion is 84.5%.
S302：The preparation of oil phase.
By bluish dogbane evaporate caused by the oil water mixture and monoglyceride of volatile oil and steam input oil phase tank in, stirring
50~70 DEG C are warming up to, stirs 8~12min, material dissolution forms oil phase.
S303：Two-phase mixtures.
Aqueous phase and oil phase are mixed, keeping temperature stirs 13~17min in 50~70 DEG C, forms two-phase mixtures liquid.
S304：Homogeneous.
By two-phase mixtures liquid in ball mill 3~5min of emulsification pretreatment.Then formed and emulsified by high pressure homogenizer homogeneous
Thing.Wherein, the parameter of homogeneous：Homogeneous speed is 2~30,000 r/min, and homogenizing time is 10~20min.
S305：Spray drying.
The obtained emulsions of step S304 are spray-dried, it is 180~200 DEG C, leaving air temp to control EAT
It is 5~10kPa for 80~100 DEG C, pressure, obtains the spray powder of bluish dogbane volatile oil, that is to say bluish dogbane extractive of volatile oil.
Preferably, the state modulator being spray-dried to emulsion is：EAT is 190 DEG C, leaving air temp is 90 DEG C, pressure is
8kPa。
S400, mixing.
The bluish dogbane volatile oil being prepared in the bluish dogbane water extract being prepared in step S200, step S300 is carried
Thing and green tea powder is taken to be mixed according to certain ratio of weight and number.Specifically, by 10~30 parts of bluish dogbane water extract and bluish dogbane
10~30 parts of mixing of extractive of volatile oil.
The mode of mixing in the present embodiment have it is a variety of, such as：Can be simply by two kinds of constituent bluish dogbane water extractions
Thing and bluish dogbane extractive of volatile oil are well mixed.
According to weight ratio can also be 1 by bluish dogbane extractive of volatile oil and ethanol:2 ratio is well mixed, so
The mixture of bluish dogbane extractive of volatile oil and ethanol is uniformly sprayed into bluish dogbane water extract afterwards, and is being sealed, is preserved
Time also determines according to actual conditions, preferably takes and is sealed 48h.Mixed using bluish dogbane extractive of volatile oil with ethanol,
Using ethanol as carrier, be advantageous to be lifted the mixture homogeneity of bluish dogbane extractive of volatile oil and bluish dogbane water extract, ethanol exists
It in preparation process, can volatilize, therefore not influence the composition and mouthfeel of product.
When the constituent of apocynum venetum health care tea also includes green tea powder, first bluish dogbane water extract and green tea powder are mixed
Close, then the mixture of bluish dogbane extractive of volatile oil and ethanol is uniformly sprayed into bluish dogbane water extract and the mixture of green tea powder
In.
Mixing bluish dogbane water extract and green tea powder mode have it is a variety of, such as：The first hybrid mode：By bluish dogbane water extraction
Mixed after thing is spray-dried with green tea powder；Or use second of hybrid mode：Bluish dogbane water extract is sprayed onto in green tea powder,
Mixing granulation.
Specifically, in the first hybrid mode：Above-mentioned bluish dogbane water extract is passed through into spray drying device, control technique ginseng
Number：120~150 DEG C of intake air temperature, 55~75 DEG C of air outlet temperature, pressure difference are 8~12kPa, feed speed is 700~
960mL/h, the extract of bluish dogbane first is made.Technological parameter is preferably：135 DEG C of intake air temperature, 60 DEG C of air outlet temperature, pressure
Difference is 10Kpa, feed speed 800mL/h.Active constituent content general flavone >=5% in the extract of bluish dogbane first, Hypericum Chinense
Glycosides content >=1%.
In second of hybrid mode, bluish dogbane water extract is sprayed onto in the green tea powder that crushed 20~50 mesh sieves, controls work
Skill parameter：60~80 DEG C of intake air temperature, 30~50 DEG C, 500~800mL/h of feed speed of air outlet temperature, spray drying moisture control
System obtains the extract of bluish dogbane second within 5%.Preferably：Control 70 DEG C of intake air temperature, 40 DEG C of air outlet temperature, feed liquor
500~800mL/h of speed, spray drying moisture are controlled within 5%.Polyphenol content >=40% in the extract of bluish dogbane second, has
Effective component content general flavone >=5%, Determination of Hyperoside >=1%.Mixed, will can be spreaded out using second of hybrid mode
Numb water extract and green tea powder are sufficiently mixed, and bluish dogbane water extract is coated on the outside of green tea powder completely, then again with bluish dogbane
Extractive of volatile oil mixes, and because bluish dogbane extractive of volatile oil is the form of spray powder, bluish dogbane extractive of volatile oil is direct
Mixed with hybrid particles, be adsorbed in the surface of hybrid particles, mixing is evenly.
The embodiment of the present invention combines bluish dogbane water extract and bluish dogbane extractive of volatile oil, and optionally adds green tea
Powder, there can be healthcare function to hypertension, high fat of blood, chemical damage simultaneously, it is convenient to take, work rapid, contrast is found
After adding bluish dogbane extractive of volatile oil in bluish dogbane water extract, the hepatoprotective effect of apocynum venetum health care tea is more obvious.Spread out
Bluish dogbane extractive of volatile oil in numb health protection tea makes full use of its active ingredient, extensive to the development and application values of bluish dogbane.
Provide only in the present embodiment the constituent of apocynum venetum health care tea with and preparation method thereof and mixed method, it is not right
Its subsequent technique is defined, the apocynum venetum health care tea that those skilled in the art will can provide according to prior art in the present embodiment
Constituent processing in tea powder, tea bag, capsule, the health food of tablets and other formulations.
Apocynum venetum health care tea provided by the invention and preparation method thereof is carried out below in conjunction with specific embodiment further
Ground explanation.
Embodiment 1
The present embodiment provide apocynum venetum health care tea constituent count in parts by weight including：10 parts of bluish dogbane water extract
With 10 parts of bluish dogbane extractive of volatile oil.
Preparation method：10kg Folium Apocyni Venetves are taken, water extraction is carried out to Folium Apocyni Veneti in the usual way, collect decocting liquid, will
In 60 DEG C, -0.1MPa's decocting liquid is concentrated under reduced pressure, and it is 60% to add ethanol to concentration of alcohol, stirs, stands overnight, and is filtered, and is received
Collect filtrate, then be concentrated under reduced pressure, obtain the concentrate of bluish dogbane decocting liquid, as bluish dogbane water extract.Volatile oil is collected simultaneously with steaming
The oil water mixture of vapour, the bluish dogbane extractive of volatile oil in oil water mixture is extracted in a conventional manner.Then according to weight
Number meter, by the 10 parts of mixing of 10 parts of bluish dogbane water extract and bluish dogbane extractive of volatile oil.Aluminium plastic packaging bag is packed, and obtains tea powder agent
The apocynum venetum health care tea of type.
Embodiment 2
The present embodiment provide apocynum venetum health care tea constituent count in parts by weight including：Bluish dogbane water extract 20
20 parts of part, 20 parts of bluish dogbane extractive of volatile oil and green tea powder.
Preparation method：S100, water extraction step：10kg Folium Apocyni Venetves are taken, add 0.05% complex enzyme formulation (albumen
Enzyme：Cellulase：Pectase=1：1：1), then soak, by water boiling and extraction technique, take Folium Apocyni Veneti and add about
The water of 10 times of volumes of Folium Apocyni Veneti, 90 DEG C decoct three times, each 1h, merge the decocting liquid for collecting bluish dogbane, while collect evaporation
The volatile oil of gained and the oil water mixture of steam.
S200, prepare bluish dogbane water extract：By decocting liquid in 60 DEG C, it is concentrated under reduced pressure under conditions of -0.1Mpa, adds ethanol extremely
Concentration of alcohol is 60%, is stirred, and is stood overnight, and filtering, collects filtrate, then is concentrated under reduced pressure, and obtains bluish dogbane water extract.
S300, prepare bluish dogbane extractive of volatile oil：Prepare emulsion 1000g.By casein-sodium, maltodextrin, sucrose
Ester input aqueous phase tank in, be dissolved in water, add water amount account for emulsion mass percent be 84.5%, stirring be warming up to 60
DEG C, material dissolution forms aqueous phase.By in oil water mixture and monoglyceride input oil phase tank, stirring is warming up to 50 DEG C, stirring
10min, material dissolution form oil phase.By two-phase mixtures, keeping temperature is under conditions of 50 DEG C, high-speed stirred 15min, forms two
Mix liquid.By two-phase mixtures liquid, the emulsification pretreatment 3min in ball mill, emulsion, homogeneous speed are formed by homogenizer homogeneous
Spend for 2.5 ten thousand r/min, homogenizing time 15min.Then emulsion is spray-dried, controls 190 DEG C of EAT, air-out
90 DEG C, pressure 7kPa of temperature, obtains bluish dogbane volatile oil spray powder, reaches yield 85%, embedding rate 88%.
S400, mixing：By above-mentioned bluish dogbane water extract by spray drying device, then by the bluish dogbane after spray drying
Water extract, bluish dogbane extractive of volatile oil and green tea powder carry out simple physical mixed and are made tea powder agent, pouch-packaged,
Technique (being sprayed into without bluish dogbane extractive of volatile oil) can be so saved, it is more cost-effective.The apocynum venetum health care tea of tea powder formulation
Can quickly it be dissolved in the water, it is capable of direct drinking after dissolving.
Embodiment 3
The present embodiment provide apocynum venetum health care tea constituent count in parts by weight including：Bluish dogbane water extract 22
130 parts of part, 22 parts of bluish dogbane extractive of volatile oil and green tea part.
Preparation method is roughly the same with embodiment 2, and its difference has at 3 points：First, in step S300：Prepare bluish dogbane volatilization
In oil extract, the parameter being spray-dried to emulsion is different from embodiment 2：EAT is 180 DEG C, leaving air temp is
80 DEG C, pressure 8kPa.Second, in step S400：In mixing, the technological parameter that is spray-dried to bluish dogbane water extract with
It is different to implement 2：150 DEG C of intake air temperature, 75 DEG C, pressure difference 12Kpa, feed speed 960mL/h of air outlet temperature.Third,
In step S400：In mixing, after the bluish dogbane water extract after spray drying is well mixed with green tea powder, by bluish dogbane volatile oil
Extract is 1 in mass ratio with ethanol:2 ratio is well mixed, then by the mixing of bluish dogbane extractive of volatile oil and ethanol
Thing is uniformly sprayed into bluish dogbane water extract and green tea powder, is sealed 48h.After well mixed, using preparing glue in the prior art
The technique of capsule, above-mentioned well mixed apocynum venetum health care tea is made to the apocynum venetum health care tea of capsule formulation.Wherein, to bluish dogbane
Water extract is carried out in spray-drying process, controls technological parameter：120 DEG C of intake air temperature, 55 DEG C of air outlet temperature, pressure difference are
8Kpa, feed speed 700mL/h.
Embodiment 4
The present embodiment provide apocynum venetum health care tea constituent count in parts by weight including：Bluish dogbane water extract 25
150 parts of part, 25 parts of bluish dogbane extractive of volatile oil and green tea powder.
Preparation method is roughly the same with embodiment 2, and its difference has at 2 points：First, in step S300：Prepare bluish dogbane volatilization
In oil extract, the parameter being spray-dried to emulsion is different from embodiment 2：EAT is 200 DEG C, leaving air temp is
100 DEG C, pressure 5kPa；Second, in step S400：In mixing, the technological parameter that is spray-dried to bluish dogbane water extract
It is different from implementing 2：135 DEG C of intake air temperature, 60 DEG C, pressure difference 10Kpa, feed speed 800mL/h of air outlet temperature.
Embodiment 5
The constituent for the apocynum venetum health care tea that the present embodiment provides is same as Example 2, and preparation method and embodiment 2
Roughly the same, its difference is：In the present embodiment, complex enzyme formulation (protease is not added in step S100 water extraction step：
Cellulase：Pectase=1：1：1) Folium Apocyni Veneti directly, is soaked into laggard water-filling to extract.
Embodiment 6
The present embodiment provide apocynum venetum health care tea constituent count in parts by weight including：Bluish dogbane water extract 30
300 parts of part, 30 parts of bluish dogbane extractive of volatile oil and green tea powder.
Preparation method：S100, water extraction step：10kg Folium Apocyni Venetves are taken, add 0.05% complex enzyme formulation (albumen
Enzyme：Cellulase：Pectase=1：1：1), then soak, by water boiling and extraction technique, take Folium Apocyni Veneti and add sieve
The water of about 12 times of volumes of cloth sesame slices, 100 DEG C decoct three times, each 1h, merge the decocting liquid for collecting bluish dogbane, while collect evaporation
The volatile oil of gained and the oil water mixture of steam.
S200, prepare bluish dogbane water extract：By decocting liquid in 60 DEG C, it is concentrated under reduced pressure under conditions of -0.1Mpa, adds ethanol extremely
Concentration of alcohol is 60%, is stirred, and is stood overnight, and filtering, collects filtrate, then is concentrated under reduced pressure, and obtains bluish dogbane water extract.
S300, prepare bluish dogbane extractive of volatile oil：Prepare emulsion 1000g.By casein-sodium, beta-schardinger dextrin, sucrose
Ester input aqueous phase tank in, be dissolved in water, add water amount account for emulsion mass percent be 84.5%, stirring be warming up to 80
DEG C, material dissolution forms aqueous phase.By in oil water mixture, monoglyceride input oil phase tank, stirring is warming up to 70 DEG C, stirs 12min,
Material dissolution forms oil phase.By two-phase mixtures, keeping temperature is under conditions of 70 DEG C, high-speed stirred 17min, forms two-phase mixtures
Liquid.By two-phase mixtures liquid, the emulsification pretreatment 5min in ball mill, by homogenizer homogeneous, homogeneous speed is 30,000 r/min, homogeneous
Time 20min.Then it is spray-dried, controls 190 DEG C of EAT, 90 DEG C of leaving air temp, pressure 10kPa, obtain bluish dogbane
Volatile oil spray powder, reach yield 85%, embedding rate 88%.
S400, mixing：Above-mentioned bluish dogbane water extract is sprayed onto in the green tea powder that crushed 20 mesh sieves, mixing granulation, then will
Bluish dogbane extractive of volatile oil is 1 in mass ratio with ethanol:2 ratio is well mixed, then by bluish dogbane extractive of volatile oil
Uniformly sprayed into bluish dogbane water extract and the hybrid particles of green tea powder with the mixture of ethanol, be sealed 48h.Then nonwoven is used
Cloth bag is packed, and obtains the apocynum venetum health care tea of tea bag formulation.Wherein, when spraying into bluish dogbane water extract to green tea powder, control technique
Parameter：60 DEG C of intake air temperature, 30 DEG C, feed speed 500mL/h of air outlet temperature, spray drying moisture are controlled within 5%.
In the present embodiment, bluish dogbane water extract is sprayed onto in green tea powder, mixing granulation, bluish dogbane water extract can be filled
Divide, be uniformly coated on the outside of green tea powder, while bluish dogbane extractive of volatile oil is mixed with ethanol, bluish dogbane can be strengthened
Adsorptivity and mixing uniformity of the extractive of volatile oil on hybrid particles, because green tea powder is highly soluble in water, when bluish dogbane protects
When strong tea is soaked in water, the green tea powder in apocynum venetum health care tea quickly dissolves, and destroys grain structure, makes spreading out for particle surface
Numb water extract and bluish dogbane extractive of volatile oil rapid dispersion and can be dissolved in the water, so as to the dissolution of apocynum venetum health care tea
Speed is fast, and the active ingredient of dissolution gradually increases, and suitable long-time brews.
Embodiment 7
The present embodiment provide apocynum venetum health care tea constituent count in parts by weight including：Bluish dogbane water extract 30
200 parts of part, 30 parts of bluish dogbane extractive of volatile oil and green tea powder.
Preparation method is roughly the same with embodiment 5, and its difference is：In the present embodiment, in step S400 mixing, to
When green tea powder sprays into bluish dogbane water extract, control technological parameter is different from embodiment 3：80 DEG C of intake air temperature, air outlet temperature
50 DEG C, feed speed 800mL/h, spray drying moisture, the mass percent of water content is set to control within 5%.
Embodiment 8
The present embodiment provide apocynum venetum health care tea constituent count in parts by weight including：Bluish dogbane water extract 30
250 parts of part, 30 parts of bluish dogbane extractive of volatile oil and green tea powder.
Preparation method is roughly the same with embodiment 5, and its difference is：In the present embodiment, in step S400 mixing, to
When green tea powder sprays into bluish dogbane water extract, control technological parameter is different from embodiment 3：70 DEG C of intake air temperature, air outlet temperature
40 DEG C, feed speed 600mL/h, spray drying moisture, the mass percent of water content is set to control within 5%.
Embodiment 9
The constituent for the apocynum venetum health care tea that the present embodiment provides is identical with the constituent in embodiment 5, preparation side
Method is roughly the same with embodiment 5, and its difference is：In the present embodiment, mixed in the mode and embodiment 3 of step S400 mixing
The mode of conjunction is different：
In embodiment 3, first bluish dogbane water extract is sprayed onto in green tea powder, mixing granulation, then by bluish dogbane volatile oil extracting
Thing is sprayed onto on hybrid particles after being mixed with ethanol.
And in the present embodiment, first bluish dogbane water extract is sprayed onto in green tea powder, mixing granulation, then by bluish dogbane volatile oil
Extract is directly well mixed with hybrid particles, without ethanol as medium.After well mixed, according to the technique system for preparing tablet
The apocynum venetum health care tea of standby Tabules.
Embodiment 10
The constituent for the apocynum venetum health care tea that the present embodiment provides is identical with the constituent in embodiment 5, preparation side
Method is roughly the same with embodiment 5, and its difference is：In the present embodiment, mixed in the mode and embodiment 3 of step S400 mixing
The mode of conjunction is different：
In embodiment 3, first bluish dogbane water extract is sprayed onto in green tea powder, mixing granulation, then by bluish dogbane volatile oil extracting
Thing is sprayed onto on hybrid particles after being mixed with ethanol.
And in the present embodiment, bluish dogbane water extract is divided into two parts, while green tea powder is also classified into two parts, a copy of it sieve
Cloth fiber crops water extract, which is sprayed in green tea powder, carries out mixing granulation, after remaining bluish dogbane water extract is spray-dried, directly with mixing
Particle, remaining green tea powder and the mixing of bluish dogbane extractive of volatile oil, in the present embodiment, bluish dogbane extractive of volatile oil also without
It need to be mixed with ethanol.
Experimental example one：Auxiliary protection chemical liver is tested
Animal：SPF level healthy adults male mice in kunming 70, body weight is between 18~22g.
Tested material：(active constituent content general flavone >=5%, Hyperoside contain apocynum extract in apocynum extract
Amount >=1%)；Apocynum extract tea powder (preparation of Xinjiang Jin Jun sunlight biologicals Science and Technology Ltd.) in embodiment 3；Positive drug：
Silybin Capsules.
Instrument：Centrifuge, ELIASA；
Reagent：Absolute ethyl alcohol (analysis is pure)；Triglyceride reagent box；
Implementation：Apocynum extract of the prior art sets two low 100mg/kgd, middle 200mg/kgd agent
Amount group, the bluish dogbane tea powder that the present embodiment 2 provides set two low 100mg/kgd, middle 200mg/kgd dosage groups, model group,
Positive drug group (legalon 31.85mg/kgd and Normal group, totally 7 groups, every group of 10 animals.With absolute ethyl alcohol (analysis
It is pure) liver injury model is caused, absolute ethyl alcohol concentration is 50% (with distilled water diluting), and 12~14mL/kgBW of mouse stomach amount (rolls over
Conjunction ethanol doses are 6000~7000mg/kgBW).Given the test agent gives the time 30 days, can extend to 45 days if necessary.
Daily oral gavage gives given the test agent, and blank control group and model control group give distilled water.Animal claims weekly
Weight adjusts given the test agent dosage twice, by body weight, once fills model control group and each sample group at the end of giving given the test agent
Stomach gives 50% ethanol 12mL/kgBW, and blank control group puts to death animal in 16 hours, determine the paddy in serum to distilled water, fasting
In pyruvic transaminase (ALT), serum in glutamic-oxalacetic transaminease (AST), serum in lactic dehydrogenase (LDH), serum active oxygen (ROS) and
Liver pathomorphology changes.
As a result table 1 is referred to：Model group mice serum ALT, AST, LDH, ROS compared with Normal group is horizontal significantly to be risen
Height (P<0.01)；Compared with model group, legalon group (P<0.01), extract low dose group (P<0.05), agent in extract
Amount group (P<0.01), preparation low dose group (P<0.05), preparation middle dosage (P<0.01) organizing conspicuousness reduces Serum ALT, AST water
It is flat；With extract low dose group, extract middle dosage ratio, preparation low dose group (P<0.05), preparation middle dosage (P<0.05).
Conclusion：Compared with common apocynum extract, apocynum extract has added its liver protection work after bluish dogbane volatile oil
With more obvious, and active constituent content general flavone >=5% in apocynum extract in extract, Determination of Hyperoside >=
1%.
The influence that the apocynum extract of table 1 and preparation are protected to chemical liver
Note：Compared with model group,*P<0.05,**P<0.01
Compared with normal group,△P<0.05,△△P<0.01
Experimental example two：Tea powder and tea bag active ingredient dissolution Experimental comparison
Instrument：Digestion instrument, high performance liquid chromatograph；
Reagent：Purified water, acetonitrile；
Material：Bluish doghane tea (the former tealeaves bought on the market), bluish dogbane tea bag (the health care food bought on the market
Product), the present embodiment 6 provide tea bag formulation apocynum venetum health care tea (Xinjiang Jin Jun sunlight biologicals Science and Technology Ltd. from
System), the present embodiment 2 provide tea powder formulation apocynum venetum health care tea (self-control of Xinjiang Jin Jun sunlight biologicals Science and Technology Ltd.).
Test method：This product is taken, is determined according to dissolution method, using purified water 900mL as dissolution medium, rotating speed is every point
50 turns of clock, is operated in accordance with the law, in 30s, 5min, 10min, 20min, 30min, takes solution appropriate, filtration, takes subsequent filtrate as confession
Test sample solution；It is appropriate that another precision weighs Hyperoside reference substance, solution is configured, as reference substance solution, according to Chinese Pharmacopoeia one
Determination of Hyperoside assay method determines under portion's bluish dogbane item.Measure structure refers to table 2 and Fig. 1.
The various preparation dissolution experimental results of the bluish dogbane of table 2
Conclusion：Compared with common dogbane tea, tea bag, the apocynum venetum health care tea that embodiment 6 and embodiment 2 provide is molten
Go out fastest, action speed faster can will effectively be taken active ingredient.
Experimental example three：Tea powder and tea bag physical property Experimental comparison
Instrument：High performance liquid chromatograph；
Reagent：Purified water, acetonitrile；
Material：(Xinjiang gold fine horse sunlight biological science and technology is limited for the apocynum venetum health care tea for the tea bag formulation that the present embodiment 6 provides
Company make by oneself), the present embodiment 2 provide tea powder formulation apocynum venetum health care tea (Xinjiang Jin Jun sunlight biologicals Science and Technology Ltd.
Self-control).
Content range pattern method：6 parts of this product is taken, every part of 0.1g, according to high effective liquid chromatography for measuring, determination sample contains
Amount.
Angle of repose test method：Determined using fixed funnel method, 1 funnel is fixed on horizontal positioned graph paper
The position (H) of 3cm height, particle is carefully poured into uppermost funnel, formed until under bottom funnel along hopper walls
Particle conical tip touch bell mouth untill, measure the diameter (2R) of conical base, calculate angle of repose (tga=H/R).
Draws moist test method：Surveyed with reference to the medicine draws moist test guideline method of four general rules of Chinese Pharmacopoeia 9103
It is fixed.
Dissolubility test method：With reference to solubility test method in the Chinese Pharmacopoeia note on the use.
The various preparation physical property experimental results of the bluish dogbane of table 3
| Sample | Mobility | Uniformity of dosage units | Draw moist | Dissolubility |
| Embodiment 2 | 35 ° of angle of repose | 10 | Slightly draw moist | Easily dissolve |
| Embodiment 6 | 30 ° of angle of repose | 5 | It is moist without drawing | It is readily soluble |
Conclusion：For bluish dogbane tea powder compared with tea bag, bluish dogbane tea bag mobility is more preferable, and moist without drawing, content is uniform
Degree is high；Bluish dogbane tea powder dissolubility is more preferable, is easy to take.
Experimental example four：
Mr. Wan, 45 years old, sales force, because of need of work, it is often necessary to treat with courtesy, every time dinner party all can heavy drinking, wine
Occur the symptoms such as nausea, headache afterwards, be engaged in this work in the past few years, body is gradually deteriorated, and fatty liver, hypertension etc. occurs in physical examination
Illness, the apocynum venetum health care tea of the offer of embodiment 2 was taken before half a year, daily 3 bags, 1 bag of bath every time is drunk, the last conventional
Fatty liver has been cured in physical examination, and blood pressure can be controlled in 130/80mmHg or so.
Experimental example five：
Mr. Wang, 40 years old, common office worker, high fat hyperpietic, the bluish dogbane health care that embodiment 2 provides was taken before half a year
Tea, daily 3 bags, 1 bag of bath every time is drunk, through examining fasting plasma lipid, T-CHOL CT, triglycerides TG and HDL
HDL, carry out drinking front and rear contrast test, then carry out curative effect comparison, subject TC, TG are remarkably decreased, and HDL substantially rises.As a result
Show, health-care tea powder of the invention, be a kind of safely and effectively preparation.
Bluish dogbane water extract and bluish dogbane extractive of volatile oil are combined as fully visible, and optionally add green tea powder,
There can be healthcare function to hypertension, high fat of blood, chemical damage simultaneously, it is convenient to take, work rapid, contrast is found in sieve
After adding bluish dogbane extractive of volatile oil in cloth fiber crops water extract, the hepatoprotective effect of apocynum venetum health care tea is more obvious.Bluish dogbane protects
Bluish dogbane extractive of volatile oil in strong tea makes full use of its active ingredient, extensive to the development and application values of bluish dogbane.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (10)
- A kind of 1. apocynum venetum health care tea, it is characterised in that its constituent count in parts by weight including：Bluish dogbane water extract 10~ 30 parts and 10~30 parts of bluish dogbane extractive of volatile oil.
- 2. apocynum venetum health care tea according to claim 1, it is characterised in that the constituent is counted in parts by weight also wraps Include：20~300 parts of green tea powder.
- 3. apocynum venetum health care tea according to claim 2, it is characterised in that the polyphenol content of the apocynum venetum health care tea >=40%, active constituent content general flavone >=5%, Determination of Hyperoside >=1%.
- A kind of 4. preparation method of apocynum venetum health care tea, it is characterised in that including：Folium Apocyni Veneti is extracted through water, decocting liquid is collected and prepares bluish dogbane water extract；The profit of volatile oil and steam is collected simultaneously Mixture prepares bluish dogbane extractive of volatile oil；AndIn parts by weight, by 10~30 parts of the bluish dogbane water extract and 10~30 parts of the bluish dogbane extractive of volatile oil Mixing.
- 5. the preparation method of apocynum venetum health care tea according to claim 4, it is characterised in that collect the oil water mixture Preparing the bluish dogbane extractive of volatile oil includes：Emulsification embedding medium is added into the oil water mixture, after forming emulsion It is spray-dried again；Wherein, the emulsification embedding medium includes casein-sodium, dextrin, sucrose ester and monoglyceride.
- 6. the preparation method of apocynum venetum health care tea according to claim 5, it is characterised in that into the oil water mixture Add the emulsification embedding dosage form includes into the emulsion：The casein-sodium, the dextrin and the sucrose ester are dissolved in water, stirring is warming up to 60~80 DEG C of formation aqueous phases；After the oil water mixture and the monoglyceride are mixed, stirring is warming up to 50~70 DEG C of formation oil phases；The aqueous phase and the oil phase are mixed, keeping temperature stirs 15min in 50~70 DEG C, forms two-phase mixtures liquid, andBy homogeneous after the two-phase mixtures liquid emulsification pretreatment, the emulsion is formed.
- 7. the preparation method of apocynum venetum health care tea according to claim 5, it is characterised in that be spray-dried the emulsion Carried out under conditions of 180~200 DEG C of EAT, 80~100 DEG C of leaving air temp, 5~10kPa of pressure.
- 8. the preparation method of apocynum venetum health care tea according to claim 4, it is characterised in that mix the bluish dogbane water extraction Thing and the bluish dogbane extractive of volatile oil include：It is first 1 in mass ratio by the bluish dogbane extractive of volatile oil and ethanol:2 ratio is well mixed, then by sieve The mixture of cloth fiber crops extractive of volatile oil and the ethanol is uniformly sprayed into the bluish dogbane water extract, is sealed.
- 9. the preparation method of apocynum venetum health care tea according to claim 8, it is characterised in that the apocynum venetum health care tea Constituent is counted in parts by weight also to be included：20~300 parts of green tea powder；Spreaded out described in the penetrating into the bluish dogbane water extract Numb extractive of volatile oil is with before the mixture of the ethanol, first mixing the bluish dogbane water extract with the green tea powder；Mixing the bluish dogbane water extract and the green tea powder includes：By the bluish dogbane water extract it is spray-dried after with it is described Green tea powder mixes；Or the bluish dogbane water extract is sprayed onto in the green tea powder, mixing granulation.
- 10. the preparation method of apocynum venetum health care tea according to claim 4, it is characterised in that spreaded out described in water extraction Before sesame slices, first the Folium Apocyni Veneti is digested using complex enzyme formulation, the weight of the complex enzyme formulation is the bluish dogbane The 0.03~0.08% of leaf weight；The complex enzyme formulation includes by weight percentage：Protease：Cellulase：Pectase =1：1：1.
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| CN109430482A (en) * | 2018-12-11 | 2019-03-08 | 南京益唯森生物科技有限公司 | A kind of organic tea of reducing blood pressure and regulating blood lipid and the preparation method and application thereof |
| CN110693928A (en) * | 2019-11-12 | 2020-01-17 | 中国科学院新疆理化技术研究所 | Use of apocynum venetum leaf polyphenol |
| CN111296597A (en) * | 2018-12-11 | 2020-06-19 | 马琳琳 | Health-care tea drink and preparation method thereof |
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| CN109430482A (en) * | 2018-12-11 | 2019-03-08 | 南京益唯森生物科技有限公司 | A kind of organic tea of reducing blood pressure and regulating blood lipid and the preparation method and application thereof |
| CN111296597A (en) * | 2018-12-11 | 2020-06-19 | 马琳琳 | Health-care tea drink and preparation method thereof |
| CN110693928A (en) * | 2019-11-12 | 2020-01-17 | 中国科学院新疆理化技术研究所 | Use of apocynum venetum leaf polyphenol |
| CN110693928B (en) * | 2019-11-12 | 2021-12-14 | 中国科学院新疆理化技术研究所 | A kind of use of apocynum leaf polyphenol |
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