CN107382885B - Preparation method of 1H-1,2, 3-triazole - Google Patents
Preparation method of 1H-1,2, 3-triazole Download PDFInfo
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- CN107382885B CN107382885B CN201710623099.4A CN201710623099A CN107382885B CN 107382885 B CN107382885 B CN 107382885B CN 201710623099 A CN201710623099 A CN 201710623099A CN 107382885 B CN107382885 B CN 107382885B
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- sodium nitrite
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
本发明公开了一种1H‑1,2,3‑三氮唑的制备方法,包括:化合物A与亚硝酸钠在溶剂I中的反应;所述化合物A为1,2‑二氨基乙烯、1,2‑二氨基乙烯的盐或上述两者的混合物。与现有生产技术相比,本发明的有益效果体现在:(1)本发明的生产路线短,目标产物的转化率高、原子利用率高、原子经济非常好。(2)摩尔收率高,总摩尔收率为90%以上。(3)溶剂均可回收套用,废水的排放量很低。(4)生产过程安全可控。The invention discloses a preparation method of 1H-1,2,3-triazole, comprising: the reaction of compound A and sodium nitrite in solvent I; the compound A is 1,2-diaminoethylene, 1 , 2-diaminoethylene salt or a mixture of the above two. Compared with the existing production technology, the beneficial effects of the present invention are reflected in: (1) the production route of the present invention is short, the conversion rate of the target product is high, the atom utilization rate is high, and the atom economy is very good. (2) The molar yield is high, and the total molar yield is more than 90%. (3) All solvents can be recycled and applied, and the discharge of waste water is very low. (4) The production process is safe and controllable.
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CN201710623099.4A CN107382885B (en) | 2017-07-27 | 2017-07-27 | Preparation method of 1H-1,2, 3-triazole |
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CN201710623099.4A CN107382885B (en) | 2017-07-27 | 2017-07-27 | Preparation method of 1H-1,2, 3-triazole |
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CN107382885A CN107382885A (en) | 2017-11-24 |
CN107382885B true CN107382885B (en) | 2020-05-12 |
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CN111704583B (en) * | 2020-07-30 | 2021-08-31 | 山东泓瑞医药科技股份公司 | Preparation method of 1H-1,2, 3-triazole |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102516186A (en) * | 2011-12-19 | 2012-06-27 | 张家港舒马克电梯安装维修服务有限公司镀锌分公司 | Preparation method for electroplating additive 5-chloro-benzotriazole |
CN105237488A (en) * | 2015-11-13 | 2016-01-13 | 如皋市金陵化工有限公司 | Synthesis method of benzotriazole |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102516186A (en) * | 2011-12-19 | 2012-06-27 | 张家港舒马克电梯安装维修服务有限公司镀锌分公司 | Preparation method for electroplating additive 5-chloro-benzotriazole |
CN105237488A (en) * | 2015-11-13 | 2016-01-13 | 如皋市金陵化工有限公司 | Synthesis method of benzotriazole |
Non-Patent Citations (1)
Title |
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六烷基胍TADC含能离子液体的合成与表征;甘志勇等;《火炸药学报》;20120229;第35卷(第1期);第19-22、31页 * |
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Denomination of invention: Preparation of 1h-1,2,3-triazole Effective date of registration: 20220124 Granted publication date: 20200512 Pledgee: Shandong Changyi rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG AOTONG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980000983 |
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Date of cancellation: 20230307 Granted publication date: 20200512 Pledgee: Shandong Changyi rural commercial bank Limited by Share Ltd. Pledgor: WEIFANG AOTONG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980000983 |
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Address after: 261311 Changyi Binhai (Xiaying) Economic Development Zone, Weifang City, Shandong Province Patentee after: Fuxiang (Shandong) New Materials Co.,Ltd. Country or region after: China Address before: No. 17 Hai'ao Road, Xiaying Economic Development Zone, Changyi City, Weifang City, Shandong Province Patentee before: WEIFANG AOTONG PHARMACEUTICAL Co.,Ltd. Country or region before: China |
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