CN107375504A - A kind of composition for preventing and treating visual fatigue and preparation method and application - Google Patents
A kind of composition for preventing and treating visual fatigue and preparation method and application Download PDFInfo
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- CN107375504A CN107375504A CN201710696095.9A CN201710696095A CN107375504A CN 107375504 A CN107375504 A CN 107375504A CN 201710696095 A CN201710696095 A CN 201710696095A CN 107375504 A CN107375504 A CN 107375504A
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Abstract
The invention discloses a kind of composition for preventing and treating visual fatigue and preparation method and application, every 100 parts by weight include the raw material of following parts by weight：10 40 parts of cassia seed, 5 30 parts of blueberry/cowberry, lutein ester/10 30 parts of lutein/Lutein ester microcapsule powder, Purple Perilla Seed Oil/10 30 parts of perilla oil microcapsule powder, 15 parts of phosphatidase 1,1 15 parts of Guarana extract, 0.1 3 parts of taurine, 0.01 0.5 parts of vitamin C, 0.001 0.1 parts of vitamin A/bata-carotene.The composition of the present invention can be used for preparing prevention and treatment visual fatigue medicine, health products and food with assistant agent compounding.The composition of the present invention has the function that supplementing eyes nutrition prevents and treats visual fatigue, available for kopiopia, the prevention and treatment of diseases such as eye is dry and astringent, foreign body sensation, eyelid sense of heaviness, blurred vision, photophobia is shed tears, eyeball is dry and astringent, eye distending pain and eye hyperemia.
Description
Technical field
The present invention relates to a kind of composition for preventing and treating visual fatigue and preparation method and application.
Background technology
Visual fatigue is a kind of common disease of current ophthalmology, and the symptom of patient is varied, and it is not independent disease, and
It is due to one group of fatigue syndrome caused by a variety of causes.
Chinese Medical Association's eye optometry group is reached common understanding according to expert's diagnosis and treatment experience within 2014, it is believed that in clear and definite visual fatigue disease
Because on the premise of, visual fatigue can be diagnosed as with occurring following symptom after eye：(1) it is not durable regard, temporary blurred vision；(2)
Eye is dry and astringent, burning sensation, itches, distending pain, sheds tears；(3) headache, dizziness, failure of memory, insomnia.With the progress of science and technology, eye
The raising of section's doctor's Clinics, the patient for being gone to a doctor and being diagnosed as visual fatigue with visual fatigue main suit increase increasingly, visual fatigue
Also result in the corresponding sites such as neck, the shoulder of people and pain occur, can also trigger and aggravate various illness in eye.Visual fatigue has had a strong impact on
The life of people, work quality, therefore it is most important to prevent and treat visual fatigue.
Alleviation method for eye fatigue, mainly there are two aspects：Loosen and supplement the nutrients.Except closing mesh rest, doing
Setting-up exercises etc. are loosened outside the method for eyes, and rational supplement eyes nutrition is one of maximally effective treatment method.It is but pre- at present
Anti- and treatment visual fatigue eye nutrition product is single, based on lutein, can not effectively treat and prevent visual fatigue.Pin
To above-mentioned phenomenon, dietary therapy of Chinese medicine and the respective advantage of modern nutriology are played, and combine modern pharmacological research result, this hair
It is bright that there is comprehensive supplement eyes nutrition, relative to the commercially available more preferable prevention and treatment visual fatigue of single eye nutrient product tool
The effect of.
The content of the invention
The technical problems to be solved by the invention are to be directed to the deficiencies in the prior art, and provide a kind of prevention and control
Composition of visual fatigue and preparation method and application is treated, visual fatigue can be both prevented and treated, eyes can be supplemented comprehensively again
Nutrition.
To achieve these goals, the present invention adopts the following technical scheme that：
Present invention firstly provides a kind of composition for preventing and treating visual fatigue, every 100 parts by weight include following parts by weight
Raw material：
Cassia seed 10-40 parts, blueberry powder/cowberry powder 5-30 parts, lutein ester/lutein/Lutein ester microcapsule powder 10-30
Part, purple perilla seed oil-bound distemper/perilla oil microcapsule powder 10-30 parts, -15 parts of phosphatidase 1, Guarana extract 1-15 parts, taurine 0.1-3
Part, vitamin C 0.01-0.5 parts, vitamin A/bata-carotene 0.001-0.1 parts.
In above-mentioned technical proposal, the composition of described prevention and treatment visual fatigue, every 100 parts by weight are further preferably wrapped
Include the raw material of following parts by weight：
30 parts of cassia seed, blueberry powder/20 parts of cowberry powder, lutein ester/15 parts of lutein/Lutein ester microcapsule powder, purple perilla
Seed oil-bound distemper/15 parts of perilla oil microcapsule powder, 0 part of phosphatidase 1,9.4 parts of Guarana extract, 0.4 part of taurine, vitamin C
0.195 part, 0.005 part of vitamin A/bata-carotene.
The present invention also provides a kind of preparation method of the composition of above-mentioned prevention and treatment visual fatigue, including following step
Suddenly：
(1) cassia seed of the ratio is put in 6-15 times of water, decocts 10-30min at 70-95 DEG C, be filtrated to get
Fried liquid and filter residue, filter residue continue to decoct 1-2 times；It is cassia seed extract solution to merge 2-3 times to decoct obtained fried liquid；Will be certainly
Pine torch extract solution is handled using existing spray drying technology, obtains cassia seed extract；
(3) by the blueberry powder of the ratio/cowberry powder, lutein ester/lutein/Lutein ester microcapsule powder, Purple Perilla Seed Oil
Powder/perilla oil microcapsule powder, phosphatide, Guarana extract, taurine 0.4, vitamin C, vitamin A/bata-carotene, with step
(1) cassia seed extract obtained is well mixed, that is, obtains the composition of described prevention and treatment visual fatigue.
The present invention also provides a kind of composition of above-mentioned prevention and treatment visual fatigue, and visual fatigue is prevented and treated preparing
Application in terms of medicine, health products and food.
In above-mentioned technical proposal, the symptom of visual fatigue refers to：Kopiopia, eye are dry and astringent, foreign body sensation, eyelid sense of heaviness, regard
The diseases such as thing is fuzzy, photophobia is shed tears, eyeball is dry and astringent, eye distending pain and eye hyperemia.
, will be described pre- when being prepared into prevention and treatment visual fatigue medicine, health products and food in above-mentioned technical proposal
Anti- and treatment visual fatigue composition is well mixed with assistant agent；Mixture is prepared into granule, piece according to this area conventional method
Agent or capsule.
In above-mentioned technical proposal, when being prepared into prevention and treatment visual fatigue medicine, health products and food, the quality of assistant agent
Percentage is 30%~90%, and surplus is the described composition for preventing and treating visual fatigue.
In above-mentioned technical proposal, described assistant agent be food additives, filler, disintegrant, lubricant, adhesive, rectify
Any one in taste agent, or the mixture that any two kinds and the above are mixed with arbitrary proportion.
In above-mentioned technical proposal, described food additives, filler, disintegrant, lubricant, adhesive, flavouring are equal
To meet GB2760《National food safety standard food additives use standard》And《Chinese Pharmacopoeia》Pharmaceutic adjuvant standard provides
Common medicinal supplementary material, such as maltodextrin, vegetable fat powder, microcrystalline cellulose, hydroxypropyl cellulose, magnesium stearate, citric acid, stevia rebaudianum
Mixture more than one or both of glucosides, Aspartame.
The advantages of technical solution of the present invention, is：The present invention can supplement eyes nutrition comprehensively, prevent and treat visual fatigue；This
Inventive composition has the function that to supplement eyes nutrition prevention and treatment visual fatigue, available for kopiopia, eye is dry and astringent, foreign body sensation,
The prevention and treatment of diseases such as eyelid sense of heaviness, blurred vision, photophobia are shed tears, eyeball is dry and astringent, eye distending pain and eye hyperemia.
Embodiment
The embodiment of technical solution of the present invention is described in detail below, but the present invention is not limited in following description
Hold：
Food additives, filler, disintegrant, lubricant, adhesive, flavouring in the embodiment of the present invention are to meet
GB2760《National food safety standard food additives use standard》And《Chinese Pharmacopoeia》Commonly used as defined in pharmaceutic adjuvant standard
Pharmaceutic adjuvant, as maltodextrin, vegetable fat powder, microcrystalline cellulose, hydroxypropyl cellulose, magnesium stearate, citric acid, steviol glycoside,
Mixture more than one or both of Aspartame.
Above raw material is existing commercially available prod, such as cassia seed is purchased from Hebei Hua Dou pharmaceutcal corporation, Ltds, and leaf is yellow
Plain ester, Purple Perilla Seed Oil are purchased from Dalian Yi Nuo limited companies, and remaining raw material, which is purchased from Beijing nandina bird food additives, to be had
Limit company.
The composition of the present invention is specifically described with reference to specific embodiment：
Embodiment 1：
A kind of granule for preventing and treating visual fatigue, is prepared by the following method：
(1) precise：Cassia seed 30kg, blueberry powder 20kg, lutein ester 15kg, purple perilla seed oil-bound distemper 15kg, phosphatide
10kg, Guarana extract 9.5kg, taurine 0.4kg, vitamin C 0.195kg, vitamin A 0.005kg, vegetable fat powder 27kg,
Maltodextrin 50kg；
(2) 30kg cassia seeds are put in 10 times of water, in 75 DEG C or so lower decoction 20min, are filtrated to get fried liquid and filter
Slag, filter residue continue to decoct 1 time；It is cassia seed extract solution to merge 2 times to decoct obtained fried liquid；Cassia seed extract solution is used
Existing spray drying technology is handled, and obtains cassia seed extract；
(3) 20kg blueberry powders, 15kg lutein esters, 15kg purple perilla seeds oil-bound distemper, 10kg phosphatide, 9.5kg Guaranas are extracted
After thing, 0.4kg taurines, 0.195kg vitamin Cs, 0.005kg vitamin As cross 80 mesh sieves respectively, determined with what step (2) obtained
Pine torch extract is mixed, and the composition of prevention and treatment visual fatigue is obtained after mixing 20min；
(4) prevention and treatment that after 27kg vegetable fat powders, 50kg maltodextrins respectively 80 mesh sieves excessively, will be obtained with step (3)
The composition of visual fatigue is mixed, and is mixed the mixture obtained after 20min and is used the granulation of existing marumerization, whole grain,
Produce the granule of prevention and treatment visual fatigue；Obtained particle is distributed into 5g/ bags, totally 30000 bags.
Human body recommended amounts for everyone (adult) 1 time a day, 1 bag every time.
Embodiment 2：
A kind of capsule for preventing and treating visual fatigue, is prepared by the following method：
(1) precise：Cassia seed 20kg, cowberry powder 25kg, lutein 25kg, perilla oil microcapsule powder 20kg, phosphatide
5kg, Guarana extract 4.5kg, taurine 0.4kg, vitamin C 0.195kg, bata-carotene 0.005kg, vegetable fat powder 28kg,
Maltodextrin 60kg；
(2) 20kg cassia seeds are put in 10 times of water, in 75 DEG C or so lower decoction 20min, are filtrated to get fried liquid and filter
Slag, filter residue continue to decoct 2 times；It is cassia seed extract solution to merge 3 times to decoct obtained fried liquid；Cassia seed extract solution is used
Existing spray drying technology is handled, and obtains cassia seed extract；
(3) 25kg cowberries powder, 25kg lutein, 20kg perilla oils microcapsule powder, 5kg phosphatide, 4.5kg Guaranas are extracted
After thing, 0.4kg taurines, 0.195kg vitamin Cs, 0.005kg bata-carotenes cross 80 mesh sieves respectively, determined with what step (2) obtained
Pine torch extract is mixed, and the composition of prevention and treatment visual fatigue is obtained after mixing 20min；
(4) prevention and treatment that after 28kg vegetable fat powders, 60kg maltodextrins respectively 80 mesh sieves excessively, will be obtained with step (3)
The composition of visual fatigue is mixed, and mixes the mixture obtained after 20min using the granulation of existing marumerization, whole grain；
Obtained particle is made to the capsule 400,000 of 400mg/ grains with full-automatic capsule filling machine, produces prevention and treatment visual fatigue
Capsule.
Human body recommended amounts for everyone (adult) 3 times a day, 4 tablets each time.
Embodiment 3：
A kind of tablet for preventing and treating visual fatigue, is prepared by the following method：
(1) precise：Cassia seed 25kg, cowberry powder 20kg, Lutein ester microcapsule powder 15kg, purple perilla seed oil-bound distemper 25kg,
Phosphatide 8kg, Guarana extract 6.5kg, taurine 0.5kg, vitamin C 0.095kg, vitamin A 0.005kg, vegetable fat powder
14kg, maltodextrin 30kg；
(2) 25kg cassia seeds are put in 10 times of water, in 80 DEG C or so lower decoction 15min, are filtrated to get fried liquid and filter
Slag, filter residue continue to decoct 1 time；It is cassia seed extract solution to merge 2 times to decoct obtained fried liquid；Cassia seed extract solution is used
Existing spray drying technology is handled, and obtains cassia seed extract；
(3) by 20kg cowberries powder, 15kg Lutein ester microcapsule powders, 25kg purple perilla seeds oil-bound distemper, 8kg phosphatide, 6.5kg Guaranas
After extract, 0.4kg taurines, 0.995kg vitamin Cs, 0.005kg vitamin As cross 80 mesh sieves respectively, obtained with step (2)
Cassia seed extract mixing, mix 20min after obtain prevent and treat visual fatigue composition；
(4) prevention and treatment that after 14kg vegetable fat powders, 30kg maltodextrins respectively 80 mesh sieves excessively, will be obtained with step (3)
The composition of visual fatigue is mixed, and mixes the mixture obtained after 20min using the granulation of existing marumerization, whole grain；
By obtained particle with 200,000, the tablet that 600mg/ pieces are made from tablet press machine entirely, the piece of prevention and treatment visual fatigue is produced
Agent.
For everyone (adult) 2 times a day, 4 tablets once for human body recommended amounts.
Application case one：The granule that embodiment 1 obtains is for the observation in terms of eyesight improvement：
1 material and method
1.1 given the test agent
The tested material and placebo are yellowish-brown granule, and outward appearance is essentially identical, and tested material presses the embodiment of the present invention one
Finished product, human body recommended amounts for everyone (adult) one time a day, through Toxicological evaluation test by each 5g, the tested material
For the product of safety, the Hygienic Index of tested material and placebo examines the pertinent regulations for meeting country..
1.2 subjects and exclusion standard
From enter one's name voluntarily participate in experiment personnel in select the age be 30-65 year, for a long time with eye, eyesight fatiguability person for by
Examination person 104.Subject Exclusion Criteria examines and assessment technique specification (version in 2003) Part II function with reference to health food
The 2nd article in Part VI in evaluation test method ".
1.3 experimental designs and packet
Using itself between group two kinds of control designs.According to symptom and eye test situation, while consider age, sex etc.
Factor, it is divided into test group and control group, several 52 people of each group of people by random, double-blind study.
1.4 test-meal methods
Test group takes tested material by recommendation method and recommended amounts, one time a day, each 5g；Control group takes placebo, uses
Method and the same test group of dosage, continuously take 35d.
1.5 observation index
Observation index is divided into safety indexes and efficiency index, indices in test-meal on-test and at the end of respectively survey
Determine once.Specific observation index reference《Health food is examined and assessment technique specification》(version in 2003) Part II " function assessment
The 5th article in Part VI in evaluation test method ".
1.6 efficiency index criterion
Being divided into symptom improves, is effective, invalid.Symptom improves：Ophthalmodynia, eye are swollen, photophobia, blurred vision, the dry and astringent any disease of eye
1 point and more than 1 point of shape improvement as improvement, any improvement of 5 kinds of symptoms and other symptoms are judgement symptom improvement without deteriorating；Have
Effect：Symptom improves and the front and rear difference >=0.1 of duration of photopic vision, and statistically significant through statistical comparison difference；It is invalid：Not up to
Effective standard.Calculating two groups of symptoms improves number of cases and two groups of symptoms improvement effective percentage.Symptom improves efficient (%) computational methods
Improve number of cases/test-meal number of cases × 100 for symptom.Two groups of symptoms are improved into efficient progress statistical test.
1.7 data processing
The data inputting database that experimental period is collected, is analyzed and statistical procedures.Symptom integral and photopic vision are lasting
Spend for measurement data, improvement rate and total effective rate are enumeration data, and t is respectively adopted and examines and x2Inspection is compared.
2 results
2.1 general information
104 visual fatigue patients, each 52 of test group, control group, test group male 32, women 20, age 30-65
Year, average age (54.05 ± 7.56) year；Control group male 30, women 22, age 31-65 year, average age (55.15
± 8.01) year.
Ordinary circumstance compares before 2.2 two groups of test-meals
Age before two groups of test-meals, sex, duration of photopic vision, left and right far visual acuity, symptom integral indices difference without
Statistical significance (P>0.05), there is comparativity.
2.3 safety indexes are observed
General physical examination, blood parameters and the routine urianlysis knot of test-meal before and after test group and control group crowd
Fruit is in normal range (NR).Test group and control group crowd Chest X-rays, electrocardiogram, abdominal B-scan ultrasonography are checked in normal range (NR) before test-meal.
2.4 distant visions, which improve, to be compared
Test group right and left eyes distant vision before test-meal than having clear improvement, the statistically significant (P of difference<0.01)；Control
Right and left eyes distant vision has clear improvement compared with before test-meal after group test-meal, the statistically significant (P of difference>0.01), it is shown in Table 1.
Influence of the test group of table 1 to subject's distant vision
Note：**Compareed with before test-meal, P<0.01；△△Compareed with after control group test-meal, P<0.01.
The change of 2.5 durations of photopic vision is compared
It is significantly improved after test group duration of photopic vision test-meal compared with before test-meal, the statistically significant (P of difference<
0.001)；Test group duration of photopic vision is relatively significantly improved with control group after test-meal, the statistically significant (P of difference<
0.001) 2, are shown in Table.
Influence of the test group of table 2 to subject's duration of photopic vision
| Packet | Before test-meal | After test-meal |
| Test group | 55.67±9.15 | 65.79±12.13***△△△ |
| Control group | 56.12±9.84 | 56.23±9.89 |
Note：***Compareed with before test-meal, P<0.001；△△△Compareed with after control group test-meal, P<0.001.
2.6 symptoms, which improve, to be compared
Test group improves to subject's eye symptom is superior to control group, is shown in Table 3.
Influence of the test group of table 3 to subject's eye symptom
2.7 symptom integral statistical comparisons
The eye symptom integration of test group by take 7.86 ± 2.64 before tested material be reduced to after taking 4.83 ±
2.59, the front and rear statistically significant (P of comparing difference<0.001)；Test group and control group (7.12 ± 2.43) are poor after test-meal
Different statistically significant (P<0.01) 4, are shown in Table.
The test group of table 4 counts to symptom integral before and after test-meal
| Packet | Before test-meal | After test-meal |
| Test group | 7.86±2.64 | 4.83±2.59***△△ |
| Control group | 7.87±2.55 | 7.12±2.43 |
Note：***Compareed with before test-meal, P<0.001；△△Compareed with after control group test-meal, P<0.01.
Total effective rate compares before and after 2.8 test-meals
Always effective number of cases is 40 to test group, total effective rate 76.92%；Always effective number of cases is 13 to control group, is always had
Efficiency is 25.00%；Two groups of statistically significant (P of total effective rate comparing difference<0.01).
According to the Ministry of Public Health《Health food is examined and assessment technique specification》(version in 2003), it is considered that product pair of the present invention
Human body, which has, alleviates visual fatigue function.During whole test-meal, the safety indexes of subject are in range of normal value
It is interior, illustrate that take product of the present invention has no adverse effects to the health for trying trencherman.
Examples detailed above is technical concept and technical characterstic to illustrate the invention, can not limit the present invention's with this
Protection domain.The equivalent transformation or modification that all essence according to the present invention is done, should all cover in protection scope of the present invention
Within.
Claims (9)
1. a kind of composition for preventing and treating visual fatigue, it is characterised in that every 100 parts by weight include the original of following parts by weight
Material：
Cassia seed 10-40 parts, blueberry powder/cowberry powder 5-30 parts, lutein ester/lutein/Lutein ester microcapsule powder 10-30 parts,
Purple perilla seed oil-bound distemper/perilla oil microcapsule powder 10-30 parts, -15 parts of phosphatidase 1, Guarana extract 1-15 parts, taurine 0.1-3 parts,
Vitamin C 0.01-0.5 parts, vitamin A/bata-carotene 0.001-0.1 parts.
2. the composition of prevention and treatment visual fatigue according to claim 1, it is characterised in that every 100 parts by weight include
The raw material of following parts by weight：
30 parts of cassia seed, blueberry powder/20 parts of cowberry powder, lutein ester/15 parts of lutein/Lutein ester microcapsule powder, Purple Perilla Seed Oil
Powder/15 parts of perilla oil microcapsule powder, 0 part of phosphatidase 1,9.5 parts of Guarana extract, 0.4 part of taurine, 0.195 part of vitamin C,
0.005 part of vitamin A/bata-carotene.
3. the preparation method of the composition of the prevention and treatment visual fatigue described in claim 1,2 any one, it is characterised in that bag
Include following steps：
(1) cassia seed of the ratio is put in 6-15 times of water, 10-30min is decocted at 70-95 DEG C, be filtrated to get fried
Liquid and filter residue, filter residue continue to decoct 1-2 times；It is cassia seed extract solution to merge 2-3 times to decoct obtained fried liquid；By cassia seed
Extract solution is handled using existing spray drying technology, obtains cassia seed extract；
(3) by the blueberry powder of the ratio/cowberry powder, lutein ester/lutein/Lutein ester microcapsule powder, purple perilla seed oil-bound distemper/purple
Perilla oil microcapsule powder, phosphatide, Guarana extract, taurine 0.4, vitamin C, vitamin A/bata-carotene, obtained with step (1)
To cassia seed extract be well mixed, that is, obtain the composition of described prevention and treatment visual fatigue.
4. the composition of the prevention and treatment visual fatigue described in claim 1,2 any one is preparing prevention and treatment visual fatigue medicine
Application in terms of thing, health products and food.
5. application according to claim 4, it is characterised in that the symptom of visual fatigue refers to：Kopiopia, eye are dry and astringent, different
The disease such as thing sense, eyelid sense of heaviness, blurred vision, photophobia is shed tears, eyeball is dry and astringent, eye distending pain and eye hyperemia.
6. application according to claim 4, it is characterised in that be prepared into prevention and treatment visual fatigue medicine, health products
And during food, the composition of described prevention and treatment visual fatigue is well mixed with assistant agent；Mixture is conventional according to this area
Method is prepared into granule, tablet or capsule.
7. application according to claim 6, it is characterised in that be prepared into prevention and treatment visual fatigue medicine, health products
And during food, the mass percent of assistant agent is 30%~90%, surplus is the described composition for preventing and treating visual fatigue.
8. application according to claim 7, it is characterised in that described assistant agent is food additives, filler, disintegration
Any one in agent, lubricant, adhesive, flavouring, or the mixing that any two kinds and the above are mixed with arbitrary proportion
Thing.
9. application according to claim 8, it is characterised in that described assistant agent refers to maltodextrin, vegetable fat powder, crystallite
Any one in cellulose, hydroxypropyl cellulose, magnesium stearate, citric acid, steviol glycoside, Aspartame, it is two or more and
The mixture mixed above with arbitrary proportion.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108713760A (en) * | 2018-05-14 | 2018-10-30 | 青岛欧潽凯药业有限公司 | A kind of antifatigue eye protecting nutritious liquid and preparation method thereof |
| CN108902974A (en) * | 2018-07-20 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of cowberry lutein capsule and preparation method thereof |
| CN109010790A (en) * | 2018-10-10 | 2018-12-18 | 丽睿客信息科技（北京）有限公司 | A kind of composition and its application for improving eye strain |
| CN110537697A (en) * | 2018-05-28 | 2019-12-06 | 许昌神飞航天生物科技有限公司 | nutritional preparation suitable for improving eyesight of astronauts |
| CN110720513A (en) * | 2019-11-21 | 2020-01-24 | 重庆市科学技术研究院 | Perilla yogurt for improving visual function and preparation method thereof |
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| CN111227154A (en) * | 2019-12-31 | 2020-06-05 | 许昌神飞航天生物科技有限公司 | Aerospace-grade nutritional solid beverage for regulating eyesight |
| CN113057298A (en) * | 2020-01-02 | 2021-07-02 | 神威药业集团有限公司 | Composition with function of relieving asthenopia and preparation method thereof |
| CN113826894A (en) * | 2021-08-30 | 2021-12-24 | 成都营养屋健康科技有限公司 | Capsule for relieving visual fatigue and preparation method thereof |
| CN114096165A (en) * | 2020-04-10 | 2022-02-25 | 上海利统生化制品有限公司 | Edible composition for relieving visual fatigue |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766307A (en) * | 2010-03-02 | 2010-07-07 | 中国农业科学院油料作物研究所 | Health food with function of relieving visual fatigue and preparation method thereof |
| CN104224890A (en) * | 2014-07-29 | 2014-12-24 | 中宏生物工程有限责任公司 | Lutein soft capsule and preparation method thereof |
| CN105918603A (en) * | 2016-04-26 | 2016-09-07 | 大连丹特生物技术有限公司 | Xylitol chewing gum having functions of resisting weariness and improving sight and preparation method of xylitol chewing gum |
| CN106265883A (en) * | 2015-05-19 | 2017-01-04 | 李萍 | One improves that muscae volitantes, vitreous opacity, degeneration of macula, glaucoma, cataract and eye be dry, eye formula puckery, asthenopic |
| CN106690287A (en) * | 2015-11-18 | 2017-05-24 | 珠海宝德润生健康科技有限公司 | Composition with function of alleviating visual fatigue and preparation method of composition |
-
2017
- 2017-08-15 CN CN201710696095.9A patent/CN107375504A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766307A (en) * | 2010-03-02 | 2010-07-07 | 中国农业科学院油料作物研究所 | Health food with function of relieving visual fatigue and preparation method thereof |
| CN104224890A (en) * | 2014-07-29 | 2014-12-24 | 中宏生物工程有限责任公司 | Lutein soft capsule and preparation method thereof |
| CN106265883A (en) * | 2015-05-19 | 2017-01-04 | 李萍 | One improves that muscae volitantes, vitreous opacity, degeneration of macula, glaucoma, cataract and eye be dry, eye formula puckery, asthenopic |
| CN106690287A (en) * | 2015-11-18 | 2017-05-24 | 珠海宝德润生健康科技有限公司 | Composition with function of alleviating visual fatigue and preparation method of composition |
| CN105918603A (en) * | 2016-04-26 | 2016-09-07 | 大连丹特生物技术有限公司 | Xylitol chewing gum having functions of resisting weariness and improving sight and preparation method of xylitol chewing gum |
Non-Patent Citations (2)
| Title |
|---|
| 俊皓韩货批发: "盘点那些风靡韩国的保健品。。。清润真综合篇", 《HTTPS://WEIDIAN.COM/P5/DIARY/PAGES/DIARY.PHP?ID=2805533》 * |
| 保健食品批文转让: "辽宁泰阳医药科技开发有限公司保健食品批发转让目录", 《HTTP://BLOG.SINA.COM.CN/S/BLOG_7EC75C4F0102WK3Q.HTML》 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108713760A (en) * | 2018-05-14 | 2018-10-30 | 青岛欧潽凯药业有限公司 | A kind of antifatigue eye protecting nutritious liquid and preparation method thereof |
| CN110537697A (en) * | 2018-05-28 | 2019-12-06 | 许昌神飞航天生物科技有限公司 | nutritional preparation suitable for improving eyesight of astronauts |
| CN108902974A (en) * | 2018-07-20 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of cowberry lutein capsule and preparation method thereof |
| CN109010790A (en) * | 2018-10-10 | 2018-12-18 | 丽睿客信息科技（北京）有限公司 | A kind of composition and its application for improving eye strain |
| CN110801516A (en) * | 2019-10-30 | 2020-02-18 | 通化力神保健品有限公司 | Eye nutrient spray liquid and preparation method thereof |
| CN110720513A (en) * | 2019-11-21 | 2020-01-24 | 重庆市科学技术研究院 | Perilla yogurt for improving visual function and preparation method thereof |
| CN111227154A (en) * | 2019-12-31 | 2020-06-05 | 许昌神飞航天生物科技有限公司 | Aerospace-grade nutritional solid beverage for regulating eyesight |
| CN113057298A (en) * | 2020-01-02 | 2021-07-02 | 神威药业集团有限公司 | Composition with function of relieving asthenopia and preparation method thereof |
| CN114096165A (en) * | 2020-04-10 | 2022-02-25 | 上海利统生化制品有限公司 | Edible composition for relieving visual fatigue |
| CN114096165B (en) * | 2020-04-10 | 2023-09-19 | 上海利统生化制品有限公司 | An edible composition for relieving visual fatigue |
| CN113826894A (en) * | 2021-08-30 | 2021-12-24 | 成都营养屋健康科技有限公司 | Capsule for relieving visual fatigue and preparation method thereof |
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