CN107367606B - Flash type detection system and flash type detection device - Google Patents
Flash type detection system and flash type detection device Download PDFInfo
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- CN107367606B CN107367606B CN201710839341.1A CN201710839341A CN107367606B CN 107367606 B CN107367606 B CN 107367606B CN 201710839341 A CN201710839341 A CN 201710839341A CN 107367606 B CN107367606 B CN 107367606B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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Abstract
The invention discloses a flash type detection system and a flash type detection device, which comprise a cleaning system for picking up, filling and drying cleaning liquid, a filling system for picking up and filling detection reagent, a detection pool for containing liquid to be detected, and a detection system for detecting objects to be detected, wherein the filling, cleaning and detection systems are connected through pipelines to realize the maintenance and the function of each system, the detection system comprises a dense light cylinder arranged above the detection pool, the dense light cylinder coincides with the central line of the detection pool, a shutter capable of being opened quickly is arranged above the dense light cylinder, a photomultiplier is arranged above the shutter, and a filling needle sequentially penetrates through the shutter and the dense light cylinder and is suspended above the detection pool. The invention adopts the filling needle arranged above the detection pool, can rapidly fill the detection reagent, and rapidly opens the shutter to measure the detection result; adopt can weather the cleaning system of washing liquid, can blow dry the pipeline after the washing liquid way, avoid remaining, clean the pipeline.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a flash type detection system and a flash type detection device.
Background
In recent years, with the development of immune technology, chemiluminescent immunoassay technology has been rapidly developed, and the luminescence type of chemiluminescent reaction is generally classified into two types of flash type and glow type; the flash type light emission time is short, and is a fraction of a second to several seconds, and the glow type is also called a continuous type, and the light emission time is from several minutes to several tens of minutes, or several hours or more.
As another example, chinese patent document CN106546758A discloses a full-automatic chemiluminescence immunoassay analyzer and a liquid path system thereof, wherein the system performs sample pick-up and filling and pick-up and filling of a luminescent acid-alkali liquid by using a plunger pump and an electromagnetic valve, and cleaning of the inner wall of a sample needle by using a washing liquid; reagent pick-up and filling using a syringe and solenoid valve; and treating the waste liquid generated by the system by using a waste liquid diaphragm pump and condensed water generated by the reagent refrigerating bin. The device of the document can realize full-automatic chemiluminescence immunoassay, but the cleaning agent remains after cleaning, so that the pipeline cannot be cleaned, and meanwhile, the flash reagent cannot be detected.
Disclosure of Invention
In order to overcome the defects, the invention aims to provide a flash type detection system which has simple liquid path, low cost, easy cleaning of a pipeline and capability of detecting a flash type reagent.
In order to achieve the above purpose, the invention adopts the following technical scheme: the utility model provides a flash type detecting system, is including being used for picking up, filling and weather cleaning system to the washing liquid, picks up, filling system and holding the detection pond of waiting to detect liquid to detect reagent to and the detecting system who waits to detect the thing, through right filling system, cleaning system and detecting system carry out the pipe connection realization each system's maintenance and function, detecting system is including locating the close light section of thick bamboo of detecting pond top, the central line coincidence of close light section of thick bamboo and detecting pond, the top of close light section of thick bamboo is equipped with the shutter that can open fast, the shutter top is equipped with photomultiplier, the filling needle link up in proper order and passes through shutter and close light section of thick bamboo and hang in the detecting pond top. The invention has the beneficial effects that: the filling needle arranged above the detection pool is adopted, so that the detection reagent can be filled quickly, and the shutter is opened quickly to measure the detection result, so that the detection device is suitable for detecting the flashing reagent; adopt can weather the cleaning system of washing liquid, can blow dry the pipeline after the washing liquid way, avoid remaining, clean the pipeline.
Preferably, the cleaning system comprises a cleaning liquid barrel, a two-way valve I, a plunger pump, a three-way valve I, a filling needle, a three-way valve II and a two-way valve II, wherein an outlet of the cleaning liquid barrel is connected with an inlet of the two-way valve I through a pipeline I, an outlet of the two-way valve I is connected with an inlet of the plunger pump through a pipeline II, an outlet of the plunger pump is connected with an inlet of the three-way valve I through a pipeline III, an outlet of the three-way valve I is connected with a bucket-shaped nozzle through a pipeline IV, the other outlet of the three-way valve I is connected with an inlet of the three-way valve II through a pipeline V, an outlet of the three-way valve II is connected with an inlet of the two-way valve II through a pipeline VI, and an outlet of the two-way valve II is connected with the filling needle through a pipeline V;
the filling system comprises a detection reagent barrel, and the detection reagent barrel is connected with the other outlet of the second three-way valve through a pipeline thirteen.
Preferably, the pipelines at the two outlets of the three-way valve II are equal in length. The two pipelines with equal length are adopted, and the flow in unit volume is equal, so that the suction quantity and the beating quantity are equal, and the accuracy of the sample adding quantity is ensured.
Preferably, the cleaning system comprises a cleaning liquid barrel, a two-way valve I, a plunger pump, a three-way joint I and a filling needle, wherein the outlet of the cleaning liquid barrel is connected with the inlet of the two-way valve I through a pipeline I, the outlet of the two-way valve I is connected with the inlet of the plunger pump through a pipeline II, the outlet of the plunger pump is connected with the inlet of the three-way joint I through a pipeline eight, one outlet of the three-way joint I is connected with the inlet of the bucket-shaped nozzle through a pipeline nine, the pipeline nine is provided with a two-way valve III, the other outlet of the three-way joint I is connected with the inlet of the three-way joint II through a pipeline II, one outlet of the three-way joint II is connected with the inlet of the two-way valve II through a pipeline I, and the outlet of the two-way valve II is connected with the filling needle through a pipeline seven; the filling system comprises a detection reagent barrel, wherein the detection reagent barrel is connected with the other outlet of the second tee joint through a pipeline twelve, and a two-way valve IV is arranged on the pipeline twelve.
Preferably, the pipeline twelve and the pipeline eleven at the two outlets of the tee joint II are equal in length. The two pipelines with equal length are adopted, and the flow in unit volume is equal, so that the suction quantity and the beating quantity are equal, and the accuracy of the sample adding quantity is ensured.
Preferably, the inner wall and the outer wall of the detection cell are all black. The full black detection pool is adopted, so that light can be effectively shielded, and the accuracy of a detection result is improved.
The invention has the beneficial effects that: by adopting a single plunger pump, a first part and a second part of the three-way valve, filling, cleaning and blow-drying of cleaning liquid and detection reagents can be realized under the condition of using one plunger pump, and the pipeline has high recycling rate, simple liquid path and lower cost.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present invention;
fig. 2 is a schematic structural diagram of another embodiment of the present invention.
In the figure:
1-a cleaning liquid barrel; 2-a two-way valve I; 3-a plunger pump; 4-a first three-way valve; 5-a filling needle; 6-line one; 7-line two;
8-line three; 9-a bucket-shaped mouth; 10-line four; 11-a two-way valve II; 12-line five; 13-a second three-way valve; 14-a detection reagent barrel; 15-line thirteen; 16-a detection cell; 17-a light-sealing cylinder; an 18-shutter; 19-photomultiplier tubes; 20-a first tee joint; 21-line eight;
22-line nine; 23-two-way valve three; 24-line ten; 25-a second tee joint; 26-line twelve; 27-a two-way valve IV; 28-a two-way valve II; 29-line eleven; 30-line six; 31-line seven.
Detailed Description
The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, thereby making clear and defining the scope of the present invention.
Example 1:
referring to fig. 1, a flash type detection system in this embodiment includes a cleaning system for picking up, filling and drying a cleaning solution, a filling system for picking up, filling a detection reagent, a detection tank 16 for containing a liquid to be detected, and a detection system for detecting an object to be detected, where maintenance and functions of each system are implemented by connecting the filling system, the cleaning system, and the detection system through pipelines. The inner and outer walls of the detection cell 16 are all opaque and completely black.
The cleaning system comprises a cleaning liquid barrel 1, a two-way valve I2, a plunger pump 3, a three-way valve I4, a filling needle 5, a three-way valve II 13 and a two-way valve II 11, wherein the outlet of the cleaning liquid barrel 1 is connected with the inlet of the two-way valve I2 through a pipeline I6, the outlet of the two-way valve I2 is connected with the inlet of the plunger pump 3 through a pipeline II 7, the outlet of the plunger pump 3 is connected with the inlet of the three-way valve I4 through a pipeline III 8, one outlet of the three-way valve I4 is connected with a bucket-shaped mouth 9 through a pipeline IV 10, the other outlet of the three-way valve I4 is connected with the inlet of the three-way valve II 13 through a pipeline IV 12, one outlet of the three-way valve II 13 is connected with the inlet of the two-way valve II 11 through a pipeline VI 30, the outlet of the two-way valve II 11 is connected with the filling needle 5 through a pipeline III 31, and the pipelines 15 and 30 at two outlets of the three-way valve II 13 should be equal in length;
the filling system comprises a detection reagent barrel 14, and the detection reagent barrel 14 is connected with the other outlet of the second three-way valve 13 through a pipeline thirteen 15;
the detection system comprises a dense light cylinder 17 arranged above the detection pool 16, the dense light cylinder 17 is overlapped with the central line of the detection pool 16, a shutter 18 capable of being rapidly opened is arranged above the dense light cylinder 17, a photomultiplier 19 is arranged above the shutter, and the filling needle 5 sequentially penetrates through the shutter 18 and the dense light cylinder 17 and is suspended above the detection pool 16.
The operation method comprises the following steps:
opening a two-way valve I2, closing an outlet of a three-way valve I4 connected with a pipeline IV 10 and an outlet of a three-way valve II 13 connected with a pipeline seven 31, starting a plunger pump 3 to suck cleaning liquid in a cleaning liquid barrel 1 into a filling needle 5 through a pipeline I6, a pipeline II 7, a pipeline III 8, a pipeline V12, a pipeline VI 30 and a pipeline V31, closing the two-way valve I2 after cleaning, exhausting and blowing the liquid through a bucket-shaped nozzle 9, closing the three-way valve I4, installing a detection tank 16, starting the plunger pump 3 to suck detection reagent in a detection reagent barrel 14 to a filling needle 5 and dripping the detection reagent into the detection tank 16, opening a shutter 18, and recording a detection result by a photomultiplier 19 and sending the detection result to the background.
Example 2:
referring to fig. 2, a flash type detection system in this embodiment includes a cleaning system for picking up, filling and drying a cleaning solution, a filling system for picking up, filling a detection reagent, a detection tank 16 for containing a liquid to be detected, and a detection system for detecting an object to be detected, where maintenance and functions of each system are implemented by connecting the filling system, the cleaning system, and the detection system through pipelines. The inner and outer walls of the detection cell 16 are all opaque and completely black.
The cleaning system comprises a cleaning liquid barrel 1, a two-way valve I2, a plunger pump 3, a three-way joint I20 and a filling needle 5, wherein the outlet of the cleaning liquid barrel 1 is connected with the inlet of the two-way valve I2 through a pipeline I6, the outlet of the two-way valve I2 is connected with the inlet of the plunger pump 3 through a pipeline II 7, the outlet of the plunger pump 3 is connected with the inlet of the three-way joint I20 through a pipeline eighth 21, one outlet of the three-way joint I20 is connected with the inlet of a bucket-shaped nozzle 9 through a pipeline nine 22, a two-way valve III 23 is arranged on the pipeline nine 22, the other outlet of the three-way joint I20 is connected with the inlet of the three-way joint II 25 through a pipeline tenth 24, one outlet of the three-way joint II 25 is connected with the inlet of the two-way valve II 28 through a pipeline eleventh 29, and the outlet of the two-way valve II 28 is connected with the filling needle 5 through a pipeline seventh 31;
the filling system comprises a detection reagent barrel 14, wherein the detection reagent barrel 14 is connected with the other outlet of the second tee joint 25 through a pipeline twelve 26, a two-way valve four 27 is arranged on the pipeline twelve 26, and the pipeline twelve 26 at the two outlets of the second tee joint 25 are equal in length with a pipeline eleven 29.
The detection system comprises a dense light cylinder 17 arranged above the detection pool 16, the dense light cylinder 17 is overlapped with the central line of the detection pool 16, a shutter 18 capable of being rapidly opened is arranged above the dense light cylinder 17, a photomultiplier 19 is arranged above the shutter, and the filling needle 5 sequentially penetrates through the shutter 18 and the dense light cylinder 17 and is suspended above the detection pool 16.
The operation method comprises the following steps:
opening the first two-way valve 2 and the second two-way valve 28, closing the third two-way valve 23 and the fourth two-way valve 27, starting the plunger pump 3 to suck the cleaning liquid in the cleaning liquid barrel 1 into the filling needle 5 through the first pipeline 6, the second pipeline 7, the eighth pipeline 21, the tenth pipeline 24, the eleventh pipeline 29 and the seventh pipeline 31, closing the first two-way valve 2 after cleaning, exhausting and blowing the liquid through the bucket-shaped mouth 9, closing the first two-way valve 2 and the third two-way valve 23, installing the detection pool 16, starting the plunger pump 3 to suck the detection reagent in the detection reagent barrel 14 into the filling needle 5 and drop the detection reagent into the detection pool 16, opening the shutter 18, recording the detection result by the photomultiplier 19, and sending the detection result to the background.
The above embodiments are only for illustrating the technical concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and to implement the same, but are not intended to limit the scope of the present invention, and all equivalent changes or modifications made according to the spirit of the present invention should be included in the scope of the present invention.
Claims (4)
1. A flash-type detection system, characterized by: the automatic cleaning device comprises a cleaning system for picking up, filling and drying cleaning liquid, a filling system for picking up and filling detection reagent, a detection pool (16) for containing liquid to be detected and a detection system for detecting objects to be detected, wherein maintenance and functions of each system are realized by carrying out pipeline connection on the filling system, the cleaning system and the detection system, the detection system comprises a dense light cylinder (17) arranged above the detection pool (16), the dense light cylinder (17) coincides with the central line of the detection pool (16), a shutter (18) capable of being opened quickly is arranged above the dense light cylinder (17), a photomultiplier (19) is arranged above the shutter, and a filling needle (5) sequentially penetrates through the shutter (18) and the dense light cylinder (17) and is suspended above the detection pool (16);
the cleaning system comprises a cleaning liquid barrel (1), a first two-way valve (2), a plunger pump (3), a first three-way valve (4), a filling needle (5), a second three-way valve (13) and a second two-way valve (11), wherein the outlet of the cleaning liquid barrel (1) is connected with the inlet of the first two-way valve (2) through a first pipeline (6), the outlet of the first two-way valve (2) is connected with the inlet of the plunger pump (3) through a second pipeline (7), the outlet of the plunger pump (3) is connected with the inlet of the first three-way valve (4) through a third pipeline (8), one outlet of the first three-way valve (4) is connected with a bucket-shaped nozzle (9) through a fourth pipeline (10), the other outlet of the first three-way valve (4) is connected with the inlet of the second three-way valve (13) through a fifth pipeline (12), one outlet of the second three-way valve (13) is connected with the inlet of the second two-way valve (11) through a sixth pipeline (30), and the outlet of the second two-way valve (11) is connected with the filling needle (5) through a seventh pipeline (31).
The filling system comprises a detection reagent barrel (14), and the detection reagent barrel (14) is connected with the other outlet of the three-way valve II (13) through a pipeline thirteen (15); the inner wall and the outer wall of the detection pool (16) are all black.
2. The flash detection system of claim 1, wherein: and the pipeline thirteen (15) and the pipeline six (30) at the two outlets of the three-way valve II (13) are equal in length.
3. A flash type detection device, characterized in that: the automatic cleaning device comprises a cleaning system for picking up, filling and drying cleaning liquid, a filling system for picking up and filling detection reagent, a detection pool (16) for containing liquid to be detected and a detection system for detecting objects to be detected, wherein maintenance and functions of each system are realized by carrying out pipeline connection on the filling system, the cleaning system and the detection system, the detection system comprises a dense light cylinder (17) arranged above the detection pool (16), the dense light cylinder (17) coincides with the central line of the detection pool (16), a shutter (18) capable of being opened quickly is arranged above the dense light cylinder (17), a photomultiplier (19) is arranged above the shutter, and a filling needle (5) sequentially penetrates through the shutter (18) and the dense light cylinder (17) and is suspended above the detection pool (16);
the cleaning system comprises a cleaning liquid barrel (1), a first two-way valve (2), a plunger pump (3), a first three-way joint (20) and a filling needle (5), wherein the outlet of the cleaning liquid barrel (1) is connected with the inlet of the first two-way valve (2) through a first pipeline (6), the outlet of the first two-way valve (2) is connected with the inlet of the plunger pump (3) through a second pipeline (7), the outlet of the plunger pump (3) is connected with the inlet of the first three-way joint (20) through a eighth pipeline (21), one outlet of the first three-way joint (20) is connected with the inlet of a bucket-shaped nozzle (9) through a ninth pipeline (22), a third two-way valve (23) is arranged on the ninth pipeline (22), the other outlet of the first three-way joint (20) is connected with the inlet of the second three-way joint (25) through a tenth pipeline (24), the inlet of the second three-way joint (25) is connected with one outlet of the second two-way valve (28) through a eleventh pipeline (29), and the outlet of the second three-way valve (28) is connected with the filling needle (5) through a seventh pipeline (31).
The filling system comprises a detection reagent barrel (14), wherein the detection reagent barrel (14) is connected with the other outlet of the three-way joint II (25) through a pipeline twelve (26), and the pipeline twelve (26) is provided with a two-way valve IV (27); the inner wall and the outer wall of the detection pool (16) are all black.
4. A flash detection device according to claim 3, wherein: and a pipeline twelve (26) and a pipeline eleven (29) at two outlets of the three-way joint II (25) are equal in length.
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| CN201710839341.1A CN107367606B (en) | 2017-09-18 | 2017-09-18 | Flash type detection system and flash type detection device |
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| CN201710839341.1A CN107367606B (en) | 2017-09-18 | 2017-09-18 | Flash type detection system and flash type detection device |
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| CN107367606A CN107367606A (en) | 2017-11-21 |
| CN107367606B true CN107367606B (en) | 2023-11-24 |
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| JP2007187474A (en) * | 2006-01-11 | 2007-07-26 | Hitachi High-Tech Manufacturing & Service Corp | Spectrophotometer measuring system and spectrophotometer measuring method |
| CN201477066U (en) * | 2009-06-23 | 2010-05-19 | 长沙开元仪器有限公司 | Rapid drainage device |
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