CN107348940B - Retinal blood flow velocity detection device based on Linnik-type near-infrared synchronous phase-shifting interference - Google Patents
Retinal blood flow velocity detection device based on Linnik-type near-infrared synchronous phase-shifting interference Download PDFInfo
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- 238000001514 detection method Methods 0.000 title claims abstract description 24
- 230000004501 retinal blood flow velocity Effects 0.000 title claims abstract description 9
- 230000001360 synchronised effect Effects 0.000 title description 2
- 230000017531 blood circulation Effects 0.000 claims abstract description 34
- 210000001525 retina Anatomy 0.000 claims abstract description 14
- 230000002207 retinal effect Effects 0.000 claims abstract description 14
- 241000276498 Pollachius virens Species 0.000 claims abstract description 12
- 238000005286 illumination Methods 0.000 claims abstract description 12
- 238000005259 measurement Methods 0.000 claims abstract description 5
- 230000003287 optical effect Effects 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 13
- 238000010146 3D printing Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 4
- 230000010363 phase shift Effects 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 230000010287 polarization Effects 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 abstract description 7
- 238000002583 angiography Methods 0.000 abstract description 5
- 238000003384 imaging method Methods 0.000 description 5
- 230000002792 vascular Effects 0.000 description 4
- 238000012014 optical coherence tomography Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 210000003733 optic disk Anatomy 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 206010061876 Obstruction Diseases 0.000 description 1
- 201000001949 Retinal Vasculitis Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000005305 interferometry Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 210000001957 retinal vein Anatomy 0.000 description 1
- 210000001210 retinal vessel Anatomy 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
- A61B5/0285—Measuring or recording phase velocity of blood waves
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- Eye Examination Apparatus (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
The invention discloses a kind of retinal blood flow speed detectors based on the interference of Linnik type near-infrared simultaneous phase-shifting, including near-infrared light source, kohler's illumination system, the first Amici prism, model eye, fixation object, collimation lens, the second Amici prism, image-forming objective lens, simultaneous phase-shifting camera and computer.Near-infrared light source generates near-infrared light beam, and the uniform after kohler's illumination system is respectively perpendicular incident human eye to be measured and model eye after the light splitting of the first Amici prism, the two-beam interference after human eye retina to be measured and the reflection of model eye rear surface.Simultaneous phase-shifting camera carries out dynamic acquisition to incident near-infrared interference light, and it is transmitted to computer, eyeground dynamic interference image is handled using simultaneous phase-shifting interferometric phase algorithm, using Doppler range rate measurement model, to treated, data are analyzed, and realize the detection of retinal blood flow speed.The present invention improves the sensitivity of retinal blood flow velocity measuring, improves the accuracy and real-time of angiography.
Description
Technical field
The invention belongs to biological tissue's parameter detecting fields, are related to a kind of based on the interference of Linnik type near-infrared simultaneous phase-shifting
Retinal blood flow speed detector.
Background technique
Numerous fine vasculars is dispersed in human eye retina, velocity of blood flow is to many ophthalmic diseases in these fine vasculars
Detection have higher directive significance, such as retinal vein obstruction, retinal vasculitis, diabetic retinopathy.Mesh
The retinal vessel angiographic method of mainstream on preceding clinical ophthalmology needs to inject fluorescer, this method side effect and medical treatment on eyeground
Risk is larger.
205391114 U of Chinese patent CN discloses " a kind of high-precision blood flow velocity detector ", including outer cover, liquid crystal
Display screen, emitter and contact pen.The system is combined using emitter and reception device, will be high using energy converter
Frequency signal is launched, and is influenced by blood flow, and Doppler effect can be generated after reflection, to the doppler shifted signal received
It is handled to obtain flow velocity waveforms signal.But since human ocular tissues are complicated and delicate, it cannot withstand the impact of high-frequency signal,
Therefore this method is not particularly suited for the detection of human eye retina's blood flow velocity.
Yali Jia of U.S. Oregon Health&Science University etc. is in " Quantitative OCT
Angiography of optic nerve head blood flow " ultrahigh speed Optical coherence tomography is used in a text,
The angiography and blood flow velocity detection of retina are completed, and has detected early stage using completely new three-dimensional angiography algorithm
The variation of the optic papilla of glaucoma.But since Optical coherence tomography is based primarily upon Overlap-scanning imaging, and eyeground is visited
The doppler angle of survey is close to 90 °, therefore the time interval between twice sweep cannot effectively shorten, and blood flow detection is insensitive.
Existing blood flow detecting device has damage human eye, and detection sensitivity is lower, cannot achieve in fine vascular
The accurate detection of faint blood flow, and lack real-time.
Summary of the invention
The purpose of the present invention is to provide a kind of retinal blood flow velocitys based on the interference of Linnik type near-infrared simultaneous phase-shifting
Detection device is spent, traditional Fundus angiography is overcome and human eye is had damage, under the premise of Non-invasive detection, utilize simultaneous phase-shifting
The method of interference gives full play to the interferometry advantage high to phse sensitivity, shortens the time of blood flow detection, improve inspection
The sensitivity of survey.
The technical solution for realizing the aim of the invention is as follows: a kind of view based on the interference of Linnik type near-infrared simultaneous phase-shifting
Nethike embrane blood flow velocity detection device, it is characterised in that: including near-infrared light source, kohler's illumination system, the first Amici prism, model
Eye, fixation object, collimation lens, the second Amici prism, image-forming objective lens, simultaneous phase-shifting camera and computer；Common optical axis is successively set
Near-infrared light source, kohler's illumination system, the first Amici prism and model eye are set, optical axis where above-mentioned component is primary optic axis；Altogether
Optical axis sets gradually human eye, the second Amici prism, the first Amici prism, image-forming objective lens and simultaneous phase-shifting camera to be measured, above-mentioned portion
Optical axis where part is the second optical axis；Common optical axis sets gradually the second Amici prism, collimation lens and fixation object, above-mentioned component institute
It is third optical axis in optical axis；Wherein primary optic axis and third optical axis are parallel to each other, and perpendicular to the second optical axis, and model eye is located at the
On the transmitted light path of one Amici prism, human eye to be measured is located on the reflected light path of the first Amici prism, and human eye to be measured is away from first
The distance of Amici prism is equidistant with the first Amici prism of model eye distance；Simultaneous phase-shifting camera is connected with computer.
The self luminous collimated collimated of fixation object is incident to the second Amici prism, reflexes to through the second Amici prism
Human eye to be measured, while near-infrared light source generates near-infrared light beam, the uniform after kohler's illumination system, through the first Amici prism
Light splitting is divided into the first reflected light and the first transmitted light, and the first reflected light enters human eye to be measured, and the first transmitted light enters model eye；
First reflected light is reflected into the first Amici prism through human eye to be measured again, and the first transmitted light is through model eye reflex to the first light splitting rib
Mirror, two-beam interference form the near-infrared interference light after interfering, regard in the near-infrared interference light after interference comprising human eye to be measured
The dynamic blood flow information of nethike embrane, concentrated lens converge to simultaneous phase-shifting camera, and simultaneous phase-shifting camera is dry to incident near-infrared
It relates to light and carries out dynamic acquisition, obtain eyeground dynamic interference image, and be transmitted to computer, utilize simultaneous phase-shifting interferometric phase algorithm
Collected eyeground dynamic interference image is handled, using Doppler range rate measurement model, to treated, data are analyzed,
Realize the detection of retinal blood flow speed.
Compared with prior art, the present invention its remarkable advantage:
(1) combination for using simultaneous phase-shifting camera and simultaneous phase-shifting Non-Interference Algorithm realizes that single acquisition obtains blood flow velocity
Information, compared with traditional intraocular fluoroscopic visualization and optical coherence chromatography imaging method, under the premise of lossless decomposition, greatly
The speed for improving blood flow detection, shorten the detection time of human eye, improve the speed and precision of blood flow detection；(2) it selects
With Linnik type interference system, it can be realized the accurate imaging to eyeground fine vascular or even visual cell, improve fundus imaging
Imaging resolution；(3) reference is used as using the 3D printing model eye based on China opthalmic optics digital model parameter, instead of
Traditional plane mirror can eliminate aberration caused by human eye to be measured to the greatest extent, improve the accuracy of detection.
Detailed description of the invention
Fig. 1 is the retinal blood flow speed detector of the invention based on the interference of Linnik type near-infrared simultaneous phase-shifting
Index path.
Fig. 2 is in the retinal blood flow speed detector of the invention based on the interference of Linnik type near-infrared simultaneous phase-shifting
Model eye schematic diagram.
Fig. 3 is in the retinal blood flow speed detector of the invention based on the interference of Linnik type near-infrared simultaneous phase-shifting
Simultaneous phase-shifting camera pixel array schematic diagram.
Specific embodiment
Present invention is further described in detail with reference to the accompanying drawing.
In conjunction with Fig. 1, a kind of retinal blood flow speed detector based on the interference of Linnik type near-infrared simultaneous phase-shifting,
It is characterized in that: saturating including near-infrared light source 1, kohler's illumination system 2, the first Amici prism 3, model eye 4, fixation object 5, collimation
Mirror 6, the second Amici prism 7, image-forming objective lens 8, simultaneous phase-shifting camera 9 and computer 10；Common optical axis sets gradually near-infrared light source
1, kohler's illumination system 2, the first Amici prism) and model eye 4, above-mentioned component place optical axis is primary optic axis；Common optical axis is successively
Human eye, the second Amici prism 7, the first Amici prism 3, image-forming objective lens 8 and simultaneous phase-shifting camera 9 to be measured, above-mentioned component institute are set
It is the second optical axis in optical axis；Common optical axis sets gradually the second Amici prism 7, collimation lens 6 and fixation object 5, above-mentioned component institute
It is third optical axis in optical axis；Wherein primary optic axis and third optical axis are parallel to each other, and perpendicular to the second optical axis, model eye 4 is located at
On the transmitted light path of first Amici prism 3, human eye to be measured is located on the reflected light path of the first Amici prism 3, and human eye to be measured away from
The distance of first Amici prism 3 being equidistant away from the first Amici prism 3 with model eye 4；Simultaneous phase-shifting camera 9 and computer 10
It is connected；
Collimated 6 collimated incident of lens of self luminous fixation object 5 is anti-through the second Amici prism 7 to the second Amici prism 7
It is incident upon human eye to be measured, while near-infrared light source 1 generates near-infrared light beam, the uniform after kohler's illumination system 2, through first point
Light prism 3 is divided, and is divided into the first reflected light and the first transmitted light, and the first reflected light enters human eye to be measured, and the first transmitted light enters
Model eye 4；First reflected light is reflected into the first Amici prism 3 through human eye to be measured again, and the first transmitted light is reflected into through model eye 4
One Amici prism 3, two-beam interference form the near-infrared interference light after interfering, include in the near-infrared interference light after interference
The dynamic blood flow information of human eye retina to be measured, concentrated lens 8 converge to simultaneous phase-shifting camera 9, and simultaneous phase-shifting camera 9 is to entering
The near-infrared interference light penetrated carries out dynamic acquisition, obtains eyeground dynamic interference image, and be transmitted to computer 10, is moved using synchronous
Interference phase algorithm handles collected eyeground dynamic interference image, using Doppler range rate measurement model to treated
Data are analyzed, and realize the detection of retinal blood flow speed.
The wavelength of the near-infrared light source 1 is 1330nm.
The model eye 4 uses 3D printing, and parameter derives from China opthalmic optics digital model, and material is organic glass
Glass.
The parameter of the model eye 4 derives from China opthalmic optics digital model, and parameter is as shown in the table:
The structural parameters of 1 China's opthalmic optics' digital model of table
Simultaneous phase-shifting camera (9) polarization angle is respectively 0 °, 45 °, 90 ° and 135 °.
The simultaneous phase-shifting interferometric phase algorithm is four step phase-shifting methods, and corresponding amount of phase shift is respectively 0, pi/2, π and 3 π/
2。
Embodiment 1
In conjunction with Fig. 1, the near-infrared solid laser device 1 of 1330nm is selected, major advantage includes: human eye scattering at the wavelength
Coefficient is high, and readily available more optical fundus blood vessel blood flow informations improve the sensitivity of blood flow detection, and the laser stability
It is good, it is not damaged to human eye.The light-emitting window of near-infrared light source 1 is arranged in kohler's illumination system 2, it is therefore intended that makes near-infrared light source 1
The light of sending can uniform, do not generate filament picture.The hot spot of uniform is divided by the first Amici prism 3, is divided into the
One reflected light and the first transmitted light, the first reflected light enter human eye to be measured, and the first transmitted light enters model eye 4；First reflected light
It is converged on retina through human lens to be measured, then scatters to the first Amici prism 3 through retina, the first transmitted light is through model
Artificial crystal in eye 4 is assembled away from artificial retina, then scatters to the first Amici prism 3 through artificial retina, is thus constituted
Linnik type interferes microscopic system.Two-beam interference, the near-infrared interference light after forming interference, the near-infrared interference after interference
It include the dynamic blood flow information of human eye retina to be measured in light, concentrated lens 8 converge to simultaneous phase-shifting camera 9, simultaneous phase-shifting
9 pairs of camera incident near-infrared interference lights carry out dynamic acquisition, obtain eyeground dynamic interference image, and be transmitted to computer 10,
Collected eyeground dynamic interference image is handled using simultaneous phase-shifting interferometric phase algorithm, utilizes Doppler range rate measurement model
To treated, data are analyzed, and realize the detection of retinal blood flow speed.For the accuracy for guaranteeing testing result, hair is utilized
The fixation object 5 of light realizes the relatively fixed of position of human eye to be measured in detection process.
In conjunction with Fig. 2,4 parameter of model eye of the 3D printing derives from China opthalmic optics digital model, and material is to have
Machine glass.China opthalmic optics digital model parameter is as shown in the table:
The structural parameters of 1 China's opthalmic optics' digital model of table
In China opthalmic optics digital model, the 1st, the front and rear surfaces that 2 faces are cornea are indicated with quadratic surface；
3rd face is the pupil position of human eye；4th, 5 face is lenticular front and rear surfaces, is also indicated using double cubic surface face shape
Method, and refractive index is gradient distribution form；6th face is retina, is expressed with standard spherical surface, curved retinal surface type
It can be good at correcting the curvature of field of angle pencil of ray.
In conjunction with Fig. 3, the simultaneous phase-shifting camera 6 is pixel array profile, and every four pixels constitute a small array,
Obtain the interference pattern of a certain position of human eye to be measured.The simultaneous phase-shifting camera polarization angle is respectively 0 °, 45 °, 90 ° and 135 °.
I.e. one acquisition can obtain four width interference patterns simultaneously, eliminate the process of conventional interference phase shift, highly shortened data and adopt
Collect the time, while improving the sensitivity of blood flow velocity detection.The simultaneous phase-shifting interferometric phase algorithm is four step phase-shifting methods,
Corresponding amount of phase shift is respectively 0, pi/2, π and 3 pi/2s.
The method that the present invention is interfered by simultaneous phase-shifting obtains human eye to be measured using 3D printing model eye as reference
Retina interference pattern recycles four step phase-shifting methods to demodulate interference fringe, to obtain weak vessel image in retina
And velocity of blood flow.Package unit is compact-sized, high sensitivity, realizes in the undamaged situation of human eye to retinal blood
The accurate detection of flow velocity degree, there is biggish application prospect.
Claims (6)
1. a kind of retinal blood flow speed detector based on the interference of Linnik type near-infrared simultaneous phase-shifting, it is characterised in that:
Including near-infrared light source (1), kohler's illumination system (2), the first Amici prism (3), model eye (4), fixation object (5), collimation
Lens (6), the second Amici prism (7), image-forming objective lens (8), simultaneous phase-shifting camera (9) and computer (10)；Common optical axis is successively set
Near-infrared light source (1), kohler's illumination system (2), the first Amici prism (3) and model eye (4) are set, optical axis where above-mentioned component is
Primary optic axis；Common optical axis set gradually human eye to be measured, the second Amici prism (7), the first Amici prism (3), image-forming objective lens (8) and
Simultaneous phase-shifting camera (9), optical axis where above-mentioned component are the second optical axis；Common optical axis sets gradually the second Amici prism (7), collimation
Lens (6) and fixation object (5), optical axis where above-mentioned component are third optical axis；Wherein primary optic axis and third optical axis are mutually flat
Row, and perpendicular to the second optical axis, model eye (4) is located on the transmitted light path of the first Amici prism (3), and human eye to be measured is located at first
On the reflected light path of Amici prism (3), and distance of the human eye to be measured away from the first Amici prism (3) and model eye (4) are away from first point
Light prism (3) are equidistant；Simultaneous phase-shifting camera (9) is connected with computer (10)；
The collimated lens of self luminous fixation object (5) (6) collimated incident is to the second Amici prism (7), through the second Amici prism
(7) human eye to be measured is reflexed to, while near-infrared light source (1) generates near-infrared light beam, uniformly gone out after kohler's illumination system (2)
It penetrates, is divided through the first Amici prism (3), be divided into the first reflected light and the first transmitted light, the first reflected light enters human eye to be measured, the
One transmitted light enters model eye (4)；First reflected light is reflected into the first Amici prism (3), the first transmitted light through human eye to be measured again
It is reflected into the first Amici prism (3) through model eye (4), two-beam interference, the near-infrared interference light after forming interference, after interference
Near-infrared interference light in include human eye retina to be measured dynamic blood flow information, imaged object lens (8) converge to simultaneous phase-shifting
Camera (9), simultaneous phase-shifting camera (9) carry out dynamic acquisition to incident near-infrared interference light, obtain eyeground dynamic interference image,
And be transmitted to computer (10), using simultaneous phase-shifting interferometric phase algorithm to collected eyeground dynamic interference image at
Reason, using Doppler range rate measurement model, to treated, data are analyzed, and realize the detection of retinal blood flow speed.
2. the retinal blood flow velocity measuring dress according to claim 1 based on the interference of Linnik type near-infrared simultaneous phase-shifting
It sets, it is characterised in that: the wavelength of the near-infrared light source (1) is 1330nm.
3. the retinal blood flow velocity measuring dress according to claim 1 based on the interference of Linnik type near-infrared simultaneous phase-shifting
It sets, it is characterised in that: the model eye (4) uses 3D printing, and parameter derives from China opthalmic optics digital model, and material is
Organic glass.
4. the retinal blood flow velocity measuring dress according to claim 3 based on the interference of Linnik type near-infrared simultaneous phase-shifting
It sets, it is characterised in that: the parameter of the model eye (4) derives from China opthalmic optics digital model, and parameter is as shown in the table:
The structural parameters of 1 China's opthalmic optics' digital model of table
5. the retinal blood flow velocity measuring dress according to claim 1 based on the interference of Linnik type near-infrared simultaneous phase-shifting
It sets, it is characterised in that: simultaneous phase-shifting camera (9) polarization angle is respectively 0 °, 45 °, 90 ° and 135 °.
6. the retinal blood flow velocity measuring dress according to claim 5 based on the interference of Linnik type near-infrared simultaneous phase-shifting
It sets, it is characterised in that: the simultaneous phase-shifting interferometric phase algorithm is four step phase-shifting methods, and corresponding amount of phase shift is respectively 0, pi/2,
π and 3 pi/2s.
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| CN102843958A (en) * | 2010-03-31 | 2012-12-26 | 佳能株式会社 | Tomographic imaging method and control device of tomographic imaging device |
| CN102985785A (en) * | 2010-07-09 | 2013-03-20 | 佳能株式会社 | Optical tomographic imaging apparatus |
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| JP4546209B2 (en) * | 2004-09-30 | 2010-09-15 | 株式会社ニデック | Ophthalmic equipment |
| US7648239B2 (en) * | 2007-05-01 | 2010-01-19 | Richard Spaide | Autofluorescence photography using a fundus camera |
| US20150230708A1 (en) * | 2012-08-23 | 2015-08-20 | University Of Washington Through Its Center For Commercialization | Methods and systems for determining volumetric properties of a tissue |
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| CN102843958A (en) * | 2010-03-31 | 2012-12-26 | 佳能株式会社 | Tomographic imaging method and control device of tomographic imaging device |
| CN102985785A (en) * | 2010-07-09 | 2013-03-20 | 佳能株式会社 | Optical tomographic imaging apparatus |
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