CN107344937A - Triazol [1,5-a] quinazoline derivative, its preparation method, pharmaceutical composition and purposes - Google Patents

Abstract

Triazol [1 of the present invention, 5 a] quinazoline derivative, its preparation method, pharmaceutical composition and purposes, a kind of compound shown in logical formula (I), its cis-trans-isomer, enantiomter, diastereoisomer, racemic modification, solvate, hydrate or its pharmaceutically acceptable salt and ester are provided, its preparation method, contain the compound pharmaceutical composition and the compound as the GABA of α 5_AThe purposes of receptor modulators, wherein T, Z, A, Y are defined as in the description.

Description

triazolo [1,5-a ] quinazoline derivative, preparation method, pharmaceutical composition and application thereof

The technical field is as follows:

the invention relates to p- α 5-GABA_AReceptorsTriazolo [1,5-a ] with modulating function]Quinazoline derivatives, their preparation, pharmaceutical compositions containing them and their use as medicaments.

Background art:

gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the central nervous system of mammals, and two types of GABA receptors exist in nature, one is GABA_AReceptors which are members of the ligand-gated ion channel superfamily, the other class being GABA_BReceptors, which are members of the superfamily of G protein-coupled receptors. GABA in mammals_AThe receptor subunits are found α 1-6, β 1-4, gamma 1-3, theta and rho 1-2, wherein the α subunit, β subunit and gamma subunit form a complete functional GABA_AThe receptor is essential, and the α subunit is p-benzodiazepine and GABA_AReceptor binding is crucial.

GABA containing α 5_AReceptor (α 5-GABA_AReceptor) in mammalian brain_AThe receptor accounts for less than 5%, and the expression level in cerebral cortex is very low, but GABA in cerebral hippocampal tissue_AThe proportion of receptors is greater than 20%, and other brain regions are hardly expressed, considering α 5-GABA_AStudy of receptor specific distribution and function in hippocampal tissues of brain, many pharmaceutical companies, including Roche, were engaged in α 5-GABA_AResearch on receptor ligands, and a large number of compounds were synthesized, especially GABA containing α 5 subunit for hippocampal tissues of brain_AInverse agonists of the receptor, of which α 5IA and MRK-016 show good therapeutic effects in the treatment of cognitive disorders in animal disease models and in human trials, particularly in the treatment of Alzheimer's disease GABA of the α 5 subunit_AInverse agonists of the receptor may be used for the treatment of cognitive disorders, in particular Alzheimer's disease patent application US 20110224278A 1 discloses GABA containing α 5 subunits_AInverse agonists of receptors are useful in the treatment of multi-infarct dementiaAnd apoplexy related diseases.

A study in the last decade has shown that (ZLokovic et al Nat Rev neurosci.; 12(12): 723-738) in many disease states, especially neurodegenerative diseases, Alzheimer's disease and stroke, the blood-brain barrier is disrupted, and even those substances which otherwise would not enter the brain can exert their pharmacological effects, and thus GABA, which otherwise would not cross α 5 subunit of the blood-brain barrier, can not cross the blood-brain barrier_AInverse agonists of the receptor are also useful in the treatment of alzheimer's disease and stroke.

Asahi laboratory report α 5-GABA in 2002_AReceptors are also predominantly expressed in small neurons and increased in the neurostimulation model (Xiao HS et al, Identification of gene expression profile of multiple root growth in the rat periphytol axotomy model of neuropathicpain. "Proc Natl Acad Sci USA 6.2002, 11 th.; 99 (12); patent application CN103239720A discloses α 5-GABA_AThe receptor is expressed in the peripheral nervous system, and the expression is very obviously increased in a nerve part damage model, and α 5-GABA_AInverse agonists of the receptor through selective binding to α 5-GABA in the peripheral nervous system_AThe receptor plays a role in inhibiting various pains, and animal experimental model data show that the stronger the inverse exciting effect of the inverse exciting agent is, the better the pain inhibiting effect is.

Detecting whether a compound is directed against GABA comprising α 5 subunit_AInverse agonists or antagonists of the receptor, for which much research has been carried out, for example in International applications WO 92/22652 and WO 94/13799, using GABA_Aα 5, β 3 and gamma 2 combinations of receptors are used to detect whether a compound binds to the receptor, and Goeders et al (Goeders NE and Kuhar M J (1985) Benzodiazepine binding vivo with. sup.3H are commonly used in drug screening]Ro 15-1788 Life Sci 37: 345-355). Detection of an energy and GABA_AThe receptor α 5 subunit binding ligands are antagonists, agonists or inverse agonists, and many studies have been made in this regard, including reference to Wafford et al (WaffordK A, Whiting P J andkemp J A (1993) Differences affinity and efficiency of benzodiazepine receptors on recombinant GABA. sub. A receptor subunit. mol. Pharmacol43: 240-).

The methods for screening whether a drug enters the blood brain barrier are relatively extensive and are described in the literature (Jones et al, pharmaceuticals and metabolic students on (3-tert-butyl-7- (5-methylisoxazol-3-yl) -2- (1-methyl-1H-1,2, 4-triazo-5-ylmethoxy) pyrazolo [1,5-d ]][1,2,4]triazine,a functionally selective GABA_Aα 5 report on the ability to detect compound inhibition in the case of reverse aginst for cognitive function Bioorg Med Chem Lett.2006Feb 15, (16), (4), (872-5)³H)R0-15-1788(α5GABA_AReceptor-labeled specific inverse agonist) binding in brain, MRK016 can effectively inhibit (³H) The central binding of R0-15-1788, while MRK016-M3 hardly inhibited (³H) R0-15-1788 is centrally combined. It can also be determined whether the drug can effectively enter the blood brain barrier by detecting the drug in different tissues, for example, by detecting the distribution ratio of the drug in the brain and the blood plasma.

Previous studies found that α 5GABA was inhibited or reduced using drugs or genetic methods_AReceptor-mediated extrasynaptic inhibition may improve cognition and learning, but at the same time lead to mild anxiety-like behavior. (Brickley, S.G.&Mody,I.Extrasynaptic GABAA receptors:their function in the CNS and implicationsfor disease.Neuron 73,23–34(2012).；Harris,D.et al.Selective influence oncontextual memory:physiochemical properties associated with selectivity ofbenzodiazepine ligands at GABAA receptors containing thealpha5subunit.J.Med.Chem.51,3788–3803(2008).；Savic′,M.M.et al.PWZ-029,acompound with moderate inverse agonist functional selectivity at GABAAreceptors containingα5subunits,improves passive,but not active,avoidancelearning in rats.Brain Res.1208,150–159(2008)；Clément,Y.et al.Gabra5-genehaplotype block associated with behavioral properties of the full agonistbenzodiazepine chlordiazepoxide.Behav.Brain Res.233,474-482(2012)).. Fear and anxiety traits were found to be associated with a decrease in Gabra5 mRNA. (Heldt, S.A.&R. J.Neurosci.26, 3631-3644 (2007), Tasan, R.O.et al, alternative GABA transmission in a motor module in a motor transmission and transmission in a motion transmission and transmission 183, 71-80 (2011), Paolo Botta et al disclose α 5GABA_AReceptor involved in anxiety and fear mechanism of brain region specific knock-out α 5GABA_AReceptor expression leads to fear and anxiety behavior in animals, thus, previously disclosed α 5GABA_AInverse agonists entering the brain produce fear and anxiety side effects that cannot be applied directly in the medical field and must be modified.

Disclosure of Invention

An object of the present invention is to provide a compound represented by the general formula (I), (II) or (III), its cis-trans isomer, enantiomer, diastereomer, racemate, solvate, hydrate, or a pharmaceutically acceptable salt or ester thereof.

Another object of the present invention is to provide a process for producing a compound represented by the general formula (I), (II) or (III).

Another object of the present invention is to provide compounds of the formula (I), (II) or (III) as α 5-GABA_AUse of a receptor modulator for the preparation of a medicament for the prevention, treatment or amelioration of α 5-GABA_AUse in medicine for a disorder related to a receptor, such as cognitive disorders, alzheimer's disease, memory disorders, down's syndrome, Amyotrophic Lateral Sclerosis (ALS), drug addiction, restless leg syndrome, cognitive deficits, multi-infarct dementia, pain, stroke, and attention deficit, or in the manufacture of a medicament for relieving pain.

Another object of the present invention is to provide a pharmaceutical composition comprising one or more therapeutically effective amounts of a compound of formula (I), (II) or (III) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier and/or adjuvant.

Another object of the present invention is to provide a method for preventing, treating or ameliorating α 5-GABA_AA method of treating a disease associated with a receptor comprising administering a compound of formula (I), (II) or (III) or a pharmaceutically acceptable salt thereof or a composition of the invention.

In a first aspect of the invention, there is provided a compound of formula II, its cis-trans isomers, enantiomers, diastereomers, racemates, solvates, hydrates, or pharmaceutically acceptable salts and esters thereof

Wherein

R4 is C1-C4 alkyl or hydroxy-substituted C1-C4 alkyl;

preferably R4 is selected from methyl and hydroxy-substituted methyl;

more preferably R4 is methyl;

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is selected from H, C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

Preferably Y1 is selected from H and C1-6 alkyl;

more preferably Y1 is selected from H and methyl;

y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, cycloalkyl, (C1-6 alkyl ) N-(C1-6 alkyl, H) N-and C1-6 alkyl-S (O)₂-；

C5-C6 heteroaryl having 1-3 heteroatoms selected from N, O or S, C5-C6 heteroaryl substituted with C1-6 alkyl having 1-3 heteroatoms selected from N, O or S;

c3-6 cycloalkyl, C3-6 cycloalkyl substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-and C1-6 alkyl-S (O)₂-；

C4-C6-heterocyclyl containing 1-3 heteroatoms selected from N, O or S, C4-C6 heterocycloalkyl containing 1-3 heteroatoms selected from N, O or S substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl and C1-6 alkyl-S (O)₂-；

Preferably Y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: hydroxy and C1-6 alkoxy;

c3-6 cycloalkyl; c3-6 cycloalkyl substituted with 1-4 substituents which are hydroxy;

more preferably Y2 is selected from hydroxy n-propanol, hydroxycyclopentyl, methyl, ethyl, methoxyethyl, or hydroxyethoxy;

most preferably Y2 is selected from 1-hydroxy-n-propanol, 2-hydroxycyclopentyl, methyl, ethyl, 2-methoxyethyl, or hydroxyethoxy;

or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

preferably either Y1, Y2 together with the N atom to which they are attached form morpholin-4-yl;

most preferably either Y1, Y2 form together with the N atom to which they are attached a morpholinyl group;

y3, Y4 are independently selected from: hydrogen, C1-C6 alkyl, SO₂-C1-C6 alkyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group.

Preferably Y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclyl selected from morpholinyl and piperidinyl.

More preferred Y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group selected from morpholin-4-yl and piperidin-1-yl.

The present invention also provides compounds having the following general formula II,

wherein,

r4 is C1-C4 alkyl or hydroxy-substituted C1-C4 alkyl;

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is selected from H, C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

Y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, cycloalkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

C5-C6 heteroaryl having 1-3 heteroatoms selected from N, O or S, C5-C6 heteroaryl substituted with C1-6 alkyl having 1-3 heteroatoms selected from N, O or S;

c3-6 cycloalkyl, C3-6 cycloalkyl substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-and C1-6 alkyl-S (O)₂-；

C4-C6-heterocyclyl containing 1-3 heteroatoms selected from N, O or S, C4-C6 heterocycloalkyl containing 1-3 heteroatoms selected from N, O or S substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl and C1-6 alkyl-S (O)₂-；

Or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

y3, Y4 are independently selected from: hydrogen, C1-C6 alkyl, SO₂-C1-C6 alkyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group.

In a preferred embodiment, in the compound of formula II,

r4 is selected from methyl and hydroxy-substituted methyl;

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is selected from H and C1-6 alkyl;

y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, cycloalkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

C5-C6 heteroaryl having 1-3 heteroatoms selected from N, O or S, C5-C6 heteroaryl substituted with C1-6 alkyl having 1-3 heteroatoms selected from N, O or S;

c3-6 cycloalkyl, C3-6 cycloalkyl substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-and C1-6 alkyl-S (O)₂-；

C4-C6-heterocyclyl containing 1-3 heteroatoms selected from N, O or S, C4-C6 heterocycloalkyl containing 1-3 heteroatoms selected from N, O or S substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl and C1-6 alkyl-S (O)₂-；

Or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

y3, Y4 are independently selected from: hydrogen, C1-C6 alkyl, SO₂-C1-C6 alkyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group.

The present invention also provides compounds having the following general formula III,

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is H or C1-6 alkyl;

y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: hydroxy and C1-6 alkoxy;

c3-6 cycloalkyl; c3-6 cycloalkyl substituted with 1-4 substituents which are hydroxy;

or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

y3 and Y4 are independently selected from: hydrogen and methyl, Y3 and Y4 form together with the nitrogen atom to which they are attached a heterocyclic group.

In a preferred embodiment, in the compound of formula III,

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is H or methyl;

y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: hydroxy and C1-6 alkoxy;

c3-6 cycloalkyl; c3-6 cycloalkyl substituted with 1-4 substituents which are hydroxy;

or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

y3 and Y4 are independently selected from: hydrogen and methyl, Y3 and Y4 form together with the nitrogen atom to which they are attached a heterocyclic group.

In a preferred embodiment, in the compound of formula III,

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is H or methyl;

y2 is selected from hydroxy n-propanol, isopropyl, hydroxycyclopentyl, methyl, ethyl, methoxyethyl, or hydroxyethoxy;

or Y1, Y2 together with the N atom to which they are attached form a morpholinyl;

y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclyl selected from morpholinyl and piperidinyl.

In a preferred embodiment, in the compound of formula III,

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is H or methyl;

y2 is selected from the group consisting of 1-hydroxy n-propanol, isopropyl, 2-hydroxycyclopentyl, methyl, ethyl, 2-methoxyethyl, and hydroxyethoxy;

or Y1, Y2 together with the N atom to which they are attached form morpholin-4-yl;

y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group selected from morpholin-4-yl and piperidin-1-yl.

In a preferred embodiment, the compound of formula II is selected from the following compounds:

the present invention also provides a composition comprising a compound as described above, or a pharmaceutically acceptable salt thereof.

The invention also provides the use of a compound or composition as described above in the manufacture of a medicament.

The invention also provides a method of treating or preventing a disease comprising administering to a patient an effective amount of a compound or composition as described above.

The inventionAlso provided is the use of a compound or composition as described herein for the preparation of a medicament for the treatment or prevention of diseases associated with α 5-GABA_AThe use in the preparation of a medicament for treating a receptor-related disease.

The invention also provides a method for treating or preventing α 5-GABA_AA method of treating a subject associated with a disorder, comprising administering to the subject an effective amount of a compound or composition described herein.

The present invention also provides the use of a compound or composition as described herein in the manufacture of a medicament for the treatment or prevention of: pain, alzheimer's disease, multi-infarct dementia and stroke.

In a preferred embodiment, the pain is neuropathic pain, inflammatory pain, and cancer pain.

In a preferred embodiment, the pain is selected from the group consisting of: headache, facial pain, neck pain, shoulder pain, back pain, chest pain, abdominal pain, back pain, low limb pain, musculoskeletal pain, vascular pain, gout, arthritic pain, visceral pain, pain caused by infectious diseases (such as AIDS and postherpetic neuralgia), bony pain, sickle cell anemia, autoimmune diseases, multiple sclerosis or inflammation-related pain, chronic pain caused by injury or surgery, nociceptive pain, painful diabetes, trigeminal neuralgia, pain in lumbar or cervical radiculopathy, glossopharyngeal neuralgia, autonomic neuropathic pain, reflex sympathetic dystrophy, nerve avulsion, cancer, chemical injury, toxins, nutritional deficiencies, viral or bacterial infections, degenerative osteoarthropathy-related pain.

The invention also provides a method of treating or preventing pain, alzheimer's disease, multi-infarct dementia and stroke, characterized by administering to a patient an effective dose of a compound or composition as described herein.

In a preferred embodiment, the pain is neuropathic pain, inflammatory pain, and cancer pain.

In a preferred embodiment, the pain is selected from the group consisting of: headache, facial pain, neck pain, shoulder pain, back pain, chest pain, abdominal pain, back pain, low limb pain, musculoskeletal pain, vascular pain, gout, arthritic pain, visceral pain, pain caused by infectious diseases (such as AIDS and postherpetic neuralgia), bony pain, sickle cell anemia, autoimmune diseases, multiple sclerosis or inflammation-related pain, chronic pain caused by injury or surgery, nociceptive pain, painful diabetes, trigeminal neuralgia, pain in lumbar or cervical radiculopathy, glossopharyngeal neuralgia, autonomic neuropathic pain, reflex sympathetic dystrophy, nerve avulsion, cancer, chemical injury, toxins, nutritional deficiencies, viral or bacterial infections, degenerative osteoarthropathy-related pain.

In the compounds of the general formula I in the present invention, T represents C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-8 bicycloalkyl, C6-10 aryl, C3-7 heterocycloalkyl; preferably T represents phenyl.

In the compounds of formula I in the present invention, Z represents a 5-membered heteroaromatic ring containing 1,2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulphur; the 5-membered heteroaromatic ring is optionally substituted with one or more substituents selected from the group consisting of: hydroxy, halogen, -R1, -OR1, -oc (o) R1, -NR2R3, CN, cyano (C1-6) alkyl-OR R2; wherein R1 represents C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkyl (C1-6) alkyl, cyano (C1-6) alkyl, hydroxy-or amino-substituted C1-6 alkyl, and R1 is optionally mono-, di-or tri-fluorinated; r2 or R3 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl or CF3, or R2 and R3 together with the nitrogen atom to which they are both attached form a 4-7 membered heteroaliphatic ring containing said nitrogen atom and one further heteroatom optionally selected from O, N and S, said ring being optionally substituted by one or more R1 groups; preferably, Z represents a 5-membered heteroaromatic ring containing 1,2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulphur, of which up to 1 heteroatom is oxygen or sulphur, and when 1 heteroatom is a nitrogen atom, at least 1 oxygen or sulphur atom is also present, the 5-membered heteroaromatic ring being optionally substituted with one or more substituents selected from: C1-C4 alkyl, hydroxy, halogen, hydroxy or amino substituted C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoxy; more preferably Z represents a5 membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from oxygen, nitrogen and sulphur, and up to 1 heteroatom is oxygen or sulphur, and when 1 heteroatom is a nitrogen atom, 1 oxygen atom or1 sulphur atom is also present; preferably Z represents a 5-membered heteroaromatic ring containing 2 heteroatoms independently selected from oxygen, nitrogen and sulphur, and one heteroatom is oxygen or sulphur and the other atom is nitrogen; the 5-membered heteroaromatic ring is optionally substituted with one or more substituents selected from the group consisting of: c1-6 alkyl or hydroxy C1-6 alkyl; preferably Z represents an oxa-diazolyl, furyl, thienyl or isoxazolyl group, optionally substituted by one or more substituents selected from: c1-6 alkyl or hydroxy C1-6 alkyl; more preferably, Z represents an oxa-diazolyl, furyl, thienyl or isoxazolyl group, optionally substituted by one or more substituents selected from: methyl or hydroxymethyl.

In the compounds of the general formula I in the present invention, A is-NR 2-; OR A is a 5-membered heteroarylene group containing 1,2,3 OR 4 heteroatoms independently selected from oxygen, nitrogen and sulfur and up to 1 of the heteroatoms being oxygen OR sulfur, OR is a 6-membered heteroarylene group containing 1,2 OR 3 nitrogen atoms, OR said 5-OR 6-membered heteroarylene group is further optionally fused to a benzene OR pyridine ring, said 5-OR 6-membered heteroarylene group being optionally substituted by Rx and/OR Ry and/OR Rz, wherein Rx is halogen, -R1, -OR1, -OC (O) R1, -C (O) OR1, -NR2R3, -NR2C (O) R3, -OH, -CN, Ry is halogen, -R1, -OR1, -OC (O) R1, -NR2R3, -NR2C (O) R3, OR CN, Rz is-R1, -OR1 OR-OC 1, with the proviso that when A is a pyridine derivative, the pyridine ring is optionally in the form of an N-oxide; or a is phenylene optionally substituted with 1,2 or 3 groups independently selected from: halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-6 cycloalkyl; preferably a represents a 5-membered heteroarylene group containing 1,2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulfur and up to 1 of the heteroatoms being oxygen or sulfur, or a 6-membered heteroarylene group or phenylene group containing 1,2 or 3 nitrogen atoms; the 5-membered heteroarylene group, the 6-membered heteroarylene group and the phenylene group are optionally substituted with a substituent selected from the group consisting of: halogen, cyano, C1-6 alkyl; more preferably a represents phenylene, pyridylene, isoxazolylene; optionally substituted with 1,2 or 3 substituents independently selected from: halogen, cyano, C1-6 alkyl;

in the compounds of the general formula (I), (II) or (III) according to the invention, Y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is selected from H, C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

Preferably Y1 is selected from H and C1-6 alkyl;

more preferably Y1 is selected from H and methyl;

y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, cycloalkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

C5-C6 heteroaryl having 1-3 heteroatoms selected from N, O or S, C5-C6 heteroaryl substituted with C1-6 alkyl having 1-3 heteroatoms selected from N, O or S;

c3-6 cycloalkyl, C3-6 cycloalkyl substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-and C1-6 alkyl-S (O)₂-；

C4-C6-heterocyclyl containing 1-3 heteroatoms selected from N, O or S, C4-C6 heterocycloalkyl containing 1-3 heteroatoms selected from N, O or S substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkylC1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl and C1-6 alkyl-S (O)₂-；

Preferably Y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: hydroxy and C1-6 alkoxy;

c3-6 cycloalkyl; c3-6 cycloalkyl substituted with 1-4 substituents which are hydroxy;

more preferably Y2 is selected from hydroxy n-propanol, hydroxycyclopentyl, methyl, ethyl, methoxyethyl, or hydroxyethoxy;

most preferably Y2 is selected from 1-hydroxy-n-propanol, 2-hydroxycyclopentyl, methyl, ethyl, 2-methoxyethyl, or hydroxyethoxy;

or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

preferably either Y1, Y2 together with the N atom to which they are attached form a morpholinyl group;

most preferably either Y1, Y2 together with the N atom to which they are attached form morpholin-4-yl;

y3, Y4 are independently selected from: hydrogen, C1-C6 alkyl, SO₂-C1-C6 alkyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group.

Preferably Y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclyl selected from morpholinyl and piperidinyl.

More preferred Y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group selected from morpholin-4-yl and piperidin-1-yl.

The present invention also relates to a process for the production of a compound of formula (II) as defined above, which process comprises:

a) reacting a compound of formula (IV)

Andreacting to obtain a compound of formula (1-3), wherein G and W are selected from Cl, Br, I, OH, OTs, OTf and OMs, R5 is alkyl, methyl, ethyl, tert-butyl, benzyl, etc.; wherein Z, Y, A is as defined above;

then reacting the compound of formula (1-3)

With Y, wherein Z, Y, A is as defined above; or

b) Reacting a compound of formula (1-4):

with Y, wherein Z, Y, A is as defined above;

c) saponifying the compound of formula (1-3) into a compound of formula (1-4), followed by reaction with Y,

wherein Z, Y, A is as defined above; or

d) Formula (II)Compounds and formulaeReaction of the compounds.

Detailed Description

The following definitions, unless otherwise indicated, are provided to illustrate and define the meaning and scope of the various terms used herein to describe the invention.

The following definitions of the general terms apply, whether appearing individually or in combination.

The naming convention used in this application is based on AutoNomTM 2000, a Beilstein Institute computerized system used to generate IUPAC system nomenclature. The chemical structures presented herein were obtained using ChemDraw version 12. Any open valency appearing on a carbon, oxygen, sulfur or nitrogen atom in the structures given herein indicates the presence of a hydrogen atom.

The term "substituted" means that the specified group or moiety may have 1,2,3, 4, 5, or 6 substituents, unless otherwise specified. When there are multiple substituents on a group and a variety of possible substituents are given, the substituents are independently selected and need not be the same.

The term "unsubstituted" means that the indicated group has no substituents.

The term "optionally substituted" means that the specified group is unsubstituted or substituted with one or more substituents independently selected from possible substituents.

When referring to the number of substituents, the term "one or more" refers to one substitution up to the maximum possible number of substitutions, i.e., one hydrogen is substituted up to all hydrogens are substituted with substituents. Preference is given to 1,2,3, 4 or 5 substituents, unless otherwise indicated.

The term "halogen" refers to fluorine, chlorine, bromine and iodine, preferably fluorine.

The term "lower alkyl" as used herein means a straight or branched chain alkyl group having 1 to 6 carbon atoms, which may be interchanged with the C1-6 alkyl group described herein, and examples of the C1-6 alkyl group include methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl groups and those specifically exemplified hereinafter. Particularly preferred "lower alkyl" groups are methyl and n-butyl.

The term "lower alkoxy" refers to the group-O-R, wherein R is lower alkyl as defined above.

The term "cycloalkyl" refers to a monovalent saturated cyclic hydrocarbon group, preferably having from 3 to 7 ring carbon atoms, more preferably from 3 to 6 carbon atoms, such as cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, as well as those specifically exemplified hereinafter.

The term "heterocyclyl" refers to a saturated or partially unsaturated monocyclic or polycyclic group having heteroatoms, preferably a monovalent 3-7 membered saturated or partially unsaturated monocyclic ring containing 1,2 or 3 ring heteroatoms selected from N, O or S. Preferably containing 1 or 2 ring heteroatoms. Preferred are 4-6 membered heterocyclyl groups containing 1 or 2 ring heteroatoms selected from N, O or S. S may be optionally substituted with two oxo groups. Examples of heterocyclyl groups are pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydropyridinyl, tetrahydropyrrolyl, azetidinyl, thiazolidinyl, oxazolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, 1-dioxo-thiomorpholin-4-yl, piperazinyl, azepanyl, diazepanyl, oxazepanyl or dihydro-oxazolyl, and those specifically exemplified below. Preferred heterocyclyl groups are morpholin-4-yl, piperidin-1-yl, pyrrolidin-1-yl, thiomorpholin-4-yl and 1, 1-dioxo-thiomorpholin-4-yl, and particularly preferred heterocyclyl groups are morpholin-4-yl, pyrrolidin-1-yl and 1, 1-dioxo-thiomorpholin-4-yl.

The term "aryl" refers to a monovalent aromatic carbocyclic ring system containing from 6 to 14, preferably from 6 to 10, carbon atoms and having at least one aromatic ring or multiple fused rings in which at least one ring is aromatic. Examples of aryl groups are phenyl, naphthyl, biphenyl or indanyl, as well as those specifically exemplified below. A preferred aryl group is phenyl, which may also be substituted, as defined below and in the claims.

The term "heteroaryl" is an aromatic group containing a heteroatom, preferably an aromatic 5-6 membered monocyclic or 9-10 membered bicyclic ring containing 1,2 or 3 atoms selected from nitrogen, oxygen and/or sulfur, for example furyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thienyl, isoxazolyl, oxazolyl, oxadiazolyl, imidazolyl, pyrrolyl, pyrazolyl, triazolyl, tetrazolyl, thiazolyl, isothiazolyl, thiadiazolyl, benzimidazolyl, indolyl, indazolyl, benzothiazolyl, benzisothiazolyl, benzoxazolyl, benzisoxazolyl, quinolinyl or isoquinolinyl, and those specifically exemplified below. Heteroaryl groups may also be substituted, as defined below and in the claims. Preferred heteroaryl groups are 5-fluoro-pyridin-2-yl.

The term "lower alkyl substituted by halogen" refers to lower alkyl mono-or poly-substituted by halogen. Examples of lower alkyl substituted by halogen are e.g. CFH₂、CF₂H、CF₃、CF₃CH₂、CF₃(CH₂)₂、(CF₃)₂CH or CF₂H-CF₂And those specifically exemplified below.

The term "lower alkyl substituted by hydroxy" refers to a lower alkyl group as defined above wherein at least one of the hydrogen atoms in the alkyl group is substituted by hydroxy. Examples of lower alkyl substituted by hydroxy include, but are not limited to, methyl, ethyl, propyl, isopropyl, isobutyl, sec-butyl, tert-butyl, pentyl or n-hexyl substituted by one or more hydroxy groups, in particular one, two or three hydroxy groups, preferably one or two hydroxy groups.

The compounds of formulae (I), (II) and (III) may form pharmaceutically acceptable acid addition salts. Examples of such pharmaceutically acceptable salts are salts of the compounds of formulae (I), (II) and (III) with physiologically compatible inorganic or organic acids, such as hydrochloric acid, sulfuric acid, sulfurous acid or phosphoric acid; organic acids are, for example, methane sulfonic acid, p-toluene sulfonic acid, acetic acid, lactic acid, trifluoroacetic acid, citric acid, fumaric acid, maleic acid, tartaric acid, succinic acid or salicylic acid. The term "pharmaceutically acceptable salts" refers to such salts. The compounds of formula (I) containing an acidic group such as COOH may also form salts with bases. Examples of such salts are alkali metal, alkaline earth metal and ammonium salts, such as Na-, K-, Ca-and trimethylammonium salts. The term "pharmaceutically acceptable salts" also refers to such salts.

The term "pharmaceutically acceptable ester" includes derivatives of the compounds of formulae (I), (II) and (III) wherein the carboxyl group is converted to an ester. Lower alkyl, lower alkyl substituted by hydroxy, lower alkyl substituted by lower alkoxy, amino-lower alkyl, mono-or di-lower alkyl-amino-lower alkyl, morpholino-lower alkyl, pyrrolidino-lower alkyl, piperidino-lower alkyl, piperazino-lower alkyl, lower alkyl-piperazino-lower alkyl and aryl-lower-alkyl ester are examples of suitable esters. Methyl, ethyl, propyl, butyl and benzyl esters are preferred. The term "pharmaceutically acceptable esters" also includes derivatives of the compounds of formula (I) wherein the hydroxyl groups are converted to the corresponding esters by inorganic or organic acids, such as nitric acid, sulfuric acid, phosphoric acid, citric acid, formic acid, maleic acid, acetic acid, succinic acid, tartaric acid, methanesulfonic acid, p-toluenesulfonic acid and the like, which are non-toxic to organisms.

Preparation method

The present invention also relates to a process for the production of a compound of formula (II) as defined above, which process comprises:

the present invention also relates to a process for the production of a compound of formula (II) as defined above, which process comprises:

a) reacting a compound of formula (IV)

Andreaction, wherein G and W are optionally Cl, Br, I, OH, OTs, OTf, OMs, etc.; r5 is alkyl, methyl, ethyl, t-butyl, benzyl, etc., then

Reacting a compound of formula (1-3)

With Y or

b) Reacting a compound of formula (1-4):

reacting with Y; or

c) Saponifying the compound of formula (1-3) into a compound of formula (1-4), followed by reaction with Y; or

d) Formula (II)Compounds and formulaeThe reaction of the compound(s) is carried out,

wherein Z, Y, A is as defined above.

Make formulaAndand (c) reacting, wherein G and W are Cl, Br, I, OH, OTs, OTf, OMs and other optional substituents. The reaction can be carried out under the conditions described in the examples or under conditions known to the person skilled in the art. For example,the reaction can be carried out in a suitable solvent (e.g., dioxane) at room temperature (e.g., 20 deg.C) under LDA, NaH, potassium or sodium t-butoxide, etc. Or production conditions for producing an ether using Mitsunobu conditions (PPh3, DEAD), a phase transfer catalyst (TBAB, crown ether), or the like.

Formula (II)The reaction of the compounds with Y to give the compounds of the formula (I) can be carried out under the conditions described in the examples or under conditions known to the person skilled in the art. For example, the reaction may be carried out in the presence of trimethylaluminum in a suitable solvent (e.g., dioxane) at elevated temperature (e.g., 85-95 ℃).

Formula (II)The reaction of the compound with Y to give the compound of formula (II) may be carried out under the conditions described in the examples or under conditions known to those skilled in the art, for example, the reaction may be carried out in the presence of H ü nigs base (N, N-diisopropylethylamine) and O- (benzotriazol-1-yl) -N, N, N ', N ' -tetramethyluronium tetrafluoroborate in a suitable solvent (e.g., dimethylformamide) at room temperature or the reaction may be carried out in the presence of 1, 1 ' -carbonyldiimidazole in a suitable solvent (e.g., dimethylformamide) at elevated temperature (e.g., 80 ℃ C.) in addition, the reaction may be carried out in the presence of 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride, N1-hydroxybenzotriazole and H ü nigs base (N, N-diisopropylethylamine) in a suitable solvent (e.g., dichloromethane) at room temperature.

Formula (II)The saponification of the compounds to the compounds of the formulae (1-4) can be carried out under the conditions described in the examples or under conditions known to the person skilled in the art. For example, the reaction may be carried out in the presence of sodium hydroxide, in a suitable solventIn an agent (such as water) at room temperature. Alternatively, the reaction may be carried out in the presence of sodium hydroxide or lithium hydroxide in a suitable solvent (such as tetrahydrofuran or water) at room temperature. Or under other conditions as described or known to those skilled in the art, such as hydrodebenzylation, acidic hydrolysis of t-butyl, and the like.

Formula (II)Compounds and formulaeThe reaction of the compounds to give the compounds of the formula (II) can be carried out under the conditions described in the examples or under conditions known to the person skilled in the art. For example, the reaction can be carried out in LDA, NaH, potassium or sodium t-butoxide, etc., in a suitable solvent (e.g., dioxane, THF, DMF, etc.) at room temperature (e.g., 20 ℃ C.). Or production conditions for producing an ether using Mitsunobu conditions (PPh3, DEAD), a phase transfer catalyst (TBAB, crown ether, etc.), etc. In a suitable solvent (e.g., dioxane, THF, DMF, etc.) at elevated temperature (e.g., 80 deg.C) to form the product under the corresponding base or catalyst conditions.

The invention also relates to compounds of formula (II) as described above, prepared by a process as described above.

The compound of formula (II) of the present invention and pharmaceutically acceptable salts thereof can be prepared by the following methods.

If their preparation is not described in the examples, the compounds of formula (II) and their intermediate products can be prepared according to analogous methods or according to the methods described previously. Starting materials known in the art can be obtained commercially or can be prepared according to methods known in the art or analogous methods to known methods.

It will be appreciated that the compounds of formula (II) of the present invention may be derivatised at functional groups to give derivatives which can be reconverted to the parent compound in vivo.

If their preparation is not described in the examples, the compounds of formula (II) and their intermediate products can be prepared according to analogous methods or according to the methods described previously. Starting materials known in the art can be obtained commercially or can be prepared according to methods known in the art or analogous methods to known methods.

It will be appreciated that the compounds of formula (II) of the present invention may be derivatised at functional groups to give derivatives which can be reconverted to the parent compound in vivo.

As mentioned above, the novel compounds of the present invention, and the pharmaceutically acceptable salts and esters thereof, have important pharmacological properties, namely α 5GABA_AAccordingly, the compounds of the present invention can be used alone or in combination with other drugs for the treatment or prevention of the disease caused by GABA containing α 5 subunit_AReceptor ligand mediated diseases. These diseases include, but are not limited to, pain, Alzheimer's disease, multi-infarct dementia, and stroke.

The invention therefore also relates to a pharmaceutical composition comprising a compound as defined above and a pharmaceutically acceptable carrier and/or adjuvant.

Also, the present invention includes a compound as described above for use in the preparation of a medicament for treating or preventing and/or preventing α 5GABA_AA medicament for the treatment or prevention of a receptor-related disease, in particular: pain, alzheimer's disease, multi-infarct dementia and stroke.

Preferably, pain is treated or prevented.

Particularly preferred is the treatment or prevention of neuropathic, inflammatory and cancerous pain.

As used herein, "cancer pain" refers to the pain that occurs during the development of a malignant tumor, which is currently thought to occur by three mechanisms, namely: pain directly from cancer development, pain following cancer treatment, and painful disease associated with cancer patients.

As used herein, "neuropathic pain" is pain that is provoked or caused by primary damage and dysfunction of the nervous system.

As used herein, "inflammatory pain" is pain caused by local acute inflammation or by chronic inflammation-stimulated nerves.

As used herein, "treating" also includes prophylactic administration, to alleviate or eliminate the condition once it is established.

As used herein, "patient" is defined as any warm-blooded animal, such as, but not limited to, a mouse, guinea pig, dog, horse or human, with the patient preferably being a human.

As used herein, "acute pain" is defined as pain caused by harmful stimuli occurring from injury and/or disease of the skin, body structure or internal organs, or pain caused by abnormal function of muscles or internal organs that do not produce actual tissue damage.

As used herein, "chronic pain" is defined as lasting beyond the usual course of an acute disease or a reasonable time for the injury to heal, or associated with a chronic pathological process that causes persistent pain, or pain that recurs at intervals of months or years, and is considered chronic if it is present after healing should have been achieved or beyond the usual course of treatment. The length of time that pain needs to elapse depends on the nature of the pain and the course of treatment associated with the pain, and if the pain exceeds the usual course of treatment, the pain is chronic. Chronic pain includes, but is not limited to, headache, facial pain, neck pain, shoulder pain, chest pain, abdominal pain, back pain, lumbago, lower limb pain, musculoskeletal pain, pain associated with somatoform mental disorder, visceral pain, painful diabetic neuropathy, vascular pain, gout, arthritic pain, cancer pain, autonomic neuroreflex pain, pain caused by infectious diseases such as aids and shingles, pain caused by autoimmune diseases (rheumatism), pain caused by acute and chronic inflammation, post-operative pain, and post-burn pain.

The medicament disclosed by the invention is effective in treating chronic pain as defined above, and the medicament disclosed by the invention can be used for treating hyperalgesia accompanied with other symptoms, including hyperalgesia, allodynia, hyperalgesia and pain memory enhancement, and the invention improves the treatment of the pain.

As used herein, "headache" can be divided into primary headaches including tension headaches, migraine headaches, and cluster headaches, and secondary headaches due to other diseases. When affected or stimulated, pain sensitive tissues of the head and face, including those distributed on the scalp, face, mouth and throat, etc., are affected and damaged, because they are mainly muscles or blood vessels of the head, contain abundant nerve fibers and are sensitive to pain, they can cause various headaches.

As used herein, "facial pain" includes, but is not limited to, trigeminal neuralgia, atypical facial pain, facial paralysis, and facial spasm.

As used herein, "trigeminal neuralgia" is a unique chronic painful condition, also known as painful convulsions, which refers to transient, paroxysmal and recurrent electrical shock-like severe pain in the trigeminal nerve distribution, or with ipsilateral muscle spasm. The trigeminal neuralgia is divided into primary trigeminal neuralgia and secondary trigeminal neuralgia, wherein the primary trigeminal neuralgia is clinically without nervous system signs and organic lesions; the secondary trigeminal neuralgia is characterized in that the nervous system signs exist clinically, and organic lesions such as tumors and inflammations are detected and discovered.

As used herein, "atypical facial pain" refers to pain caused by a variety of etiologies. It is manifested as persistent burning-like pain, no intermittency, no association with specific actions or triggering stimuli, mostly bilateral, pain often outside the trigeminal range and even affecting the neck skin. The causes of the disease can be nasosinusitis, malignant tumor, infection of jaw and skull base and the like, which stimulate or injure trigeminal nerve to cause pain.

As used herein, "neck pain, back pain, shoulder pain" refers to pain due to acute and chronic muscle strain, degeneration of bone joints, trauma, and the like. Common diseases causing pains on the neck, the shoulder and the upper limb comprise neck-shoulder myofascitis, neck-ligament inflammation, cervical spondylosis, scapulohumeral periarthritis, thoracic outlet syndrome, external humeral epicondylitis and the like, or the pains caused by autoimmune diseases are common in diseases such as rheumatoid arthritis, ankylosing spondylitis, rheumatoid arthritis and the like, and other diseases possibly causing neck pain, back pain and shoulder pain comprise tumors of the neck and the shoulder, neuritis, arteriovenous diseases, various infections, involvement pain caused by pathological changes of thoracic organs and abdominal organs and the like.

As used herein, "chest, abdominal and back pain" refers to pain due to disease of the thoracoabdominal viscera, thoracoabdominal wall tissues, including but not limited to intercostal neuralgia, intercostal chondritis, angina, abdominal pain (acute abdominal visceral pain) and psoas myofascial syndrome.

As used herein, "low back, low limb pain" refers to low back, lumbosacral, sacroiliac, hip, and low limb pain. The pain of the waist and the lower limbs is not independent diseases but has the common characteristics of various diseases, has various clinical manifestations and very complex causes, and has many degenerative and injurious symptoms, including but not limited to pain related to lumbar disc herniation, acute lumbar sprain, sciatica, osteoporosis, third lumbar transverse process syndrome, piriformis syndrome, knee osteoarthritis, tail pain, heel pain and the like.

As used herein, "musculoskeletal pain" includes, but is not limited to, myofascial pain, trauma-induced pain, and chronic regional pain syndrome.

As used herein, "painful diabetes" refers to pain that results from nerve damage that is concomitant to diabetes, in which nerve damage is caused, at least in part, by reduced blood flow and hyperglycemia. Some diabetic patients do not develop neuropathy, while others develop the disease early, and diabetic neuropathy can be classified into mononeuropathies and generalized polyneuropathy involving one or more focal sites, which can be diffuse and symmetric, usually involving mainly sensory modalities (Merrit's Textbook of Neurology, 9 th edition, edited by LPRowland LP). Manifestations of diabetic neuropathy may include autonomic nerve dysfunction leading to dysregulation including heart, smooth muscle and glands, resulting in hypotension, diarrhea, constipation and impotence. Diabetic neuropathy often develops in stages, occurring early in the nerve ending region, in the foot when autonomic or sensory neuropathy occurs, in cranial neuropathy occurs around the face and eyes, with intermittent pain and tingling, and in later stages, pain is more intense and frequent, and finally, when pain is lost in an area, painless neuropathy occurs, with the absence of pain as an indicator of injury, greatly increasing the risk of severe tissue damage.

As used herein, "visceral pain" includes, but is not limited to, pain associated with Irritable Bowel Syndrome (IBS), with or without Chronic Fatigue Syndrome (CFS), Inflammatory Bowel Disease (IBD), and interstitial cystitis.

As used herein, "vascular pain" is pain that results from one or more of the following factors. First, the perfusion of the tissue is not proper. Causing transient or continuous ischemia, such as occurs in limb muscles during exercise; second, late changes. Ulcers or gangrene, for example, in the skin or abdominal viscera; third, sudden or accelerated changes in the calibre of large vessels. Changes such as those occurring in aneurysms; fourth, the aorta ruptures. The result is blood extravasation, stimulation of nociceptive fibers in the peritoneum or parietal pleura; fifth, strong spasm due to severe stimulation of arterial endothelium by intra-arterial injection; sixth, damage from venous return results in massive edema that rapidly dilates The fascial compartment (Bonica et al, The Management of Pain, first roll (second edition), Philadelphia; Lea & Feboger, 1990). Examples include, but are not limited to, arteriosclerosis obliterans, thromboangiitis obliterans, acute arterial closure, embolism, congenital arteriovenous tumors, vasospastic diseases, Rayaud's disease, cyanosis of hands and feet, acute venous closure, thrombophlebitis, varicose veins and lymphedema.

As used herein, "autonomic reflex pain" refers to pain caused by the "reflex sympathetic atrophy signature". Reflex sympathetic atrophy is characterized by severe spontaneous pain after acute and chronic injury, and can be accompanied by edema and blood circulation disorder, and symptoms such as skin and musculoskeletal dystrophy and atrophy.

As used herein, "post-operative pain" refers to a complex physiological response of the body to the disease itself and to the tissue damage resulting from surgery, which is manifested as an unpleasant experience in mind and behavior.

As used herein, "arthritic pain" includes, but is not limited to, pain resulting from diseases such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthropathy, gout, pseudogout, infectious arthritis, tendonitis, bursitis, bone damage, and joint soft tissue inflammation.

As used herein, "postherpetic neuralgia" refers to the intense pain that persists long beneath the skin in the original rash area after the healing of the rash of herpes zoster.

As used herein, "nociceptive pain" is pain caused by a process of tissue damage that stimulates the afferent passage of nociceptors, or pain caused by prolonged excitation of nociceptors. Pain caused by prolonged excitation of nociceptors may be due to persistent noxious stimulation of nociceptors or their sensitization or both, or they may be caused by these factors and prolonged by their persistence, various reflex mechanisms and other factors.

Pharmaceutical composition

The present invention provides compositions comprising a therapeutically effective amount of α 5-GABA_Aα 5-GABA despite use in the treatment of the present invention_AReverse excitationThe animal agent may be administered as the starting compound, but preferably the active ingredient, optionally in the form of a physiologically acceptable salt, is mixed with one or more additives, excipients, carriers, buffers, diluents and/or other conventional pharmaceutical excipients to form a pharmaceutical composition.

In a preferred embodiment, the present invention provides α 5-containing GABA_APharmaceutical compositions of inverse agonists of which α 5-GABA_AThe inverse agonist is mixed with one or more pharmaceutically acceptable carriers, and optionally with other therapeutic and/or prophylactic components known or used in the art. The carrier must be "acceptable" in the sense of being compatible with the other ingredients of the formulation and not deleterious to the recipient thereof.

The pharmaceutical compositions for use in the present invention may be those suitable for oral, rectal, bronchial, nasal, pulmonary, topical (including buccal and sublingual), transdermal, vaginal or parenteral (including dermal, subcutaneous, intramuscular, intraperitoneal, intravenous, intraarterial, intracerebral, intraocular injection or infusion) administration, or those in a form suitable for administration by inhalation or spray, including powder and liquid aerosol administration, or sustained release systems. Examples of suitable sustained release systems include semipermeable matrices of solid hydrophobic polymers containing the compound of the invention, which matrices may be in the form of shaped articles, e.g., films, or microcapsules.

The compounds for use in the present invention may thus be formulated together with conventional additives, or diluents, into pharmaceutical compositions and unit dosage forms thereof. Forms such as these include solids (especially in the form of tablets, filled capsules, powders and pills), and liquids (especially aqueous or non-aqueous solutions, suspensions, emulsions, elixirs), and capsules filled with the above forms, all forms for oral administration, suppositories for rectal administration, and sterile injectable solutions for parenteral administration. Such pharmaceutical compositions and unit dosage forms thereof may comprise conventional ingredients in conventional proportions, with or without additional active compounds or ingredients, and such unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the desired daily dosage range to be employed.

The compounds for use in the present invention may be administered in a variety of oral and parenteral dosage forms. It will be apparent to those skilled in the art that the following dosage forms may contain, as the active ingredient, a compound of the present invention or a pharmaceutically acceptable salt thereof.

For formulating the compounds for use in the present invention into pharmaceutical compositions, the pharmaceutically acceptable carrier may be either solid or liquid. Solid form preparations include powders, tablets, nine doses, capsules, cachets, suppositories, and dispersible granules. A solid carrier can be one or more substances that also function as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material.

In powders, the carrier is a finely divided solid which is in admixture with the finely divided active ingredient.

In tablets, the active ingredient is mixed with a carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired.

Powders and tablets preferably contain from 5% or 10% to about 70% of the active compound. Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term "formulation" includes a composition comprising an active compound formulated with an encapsulating material as a carrier, the encapsulating material providing a capsule in which the active ingredient, with or without a carrier, is surrounded by a carrier and thus held together. Similarly, formulations include cachets and lozenges (lozenes). Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid forms suitable for oral administration.

To prepare suppositories, a low melting wax, such as a puree of fatty acid glycerides or cocoa butter, is first melted and the active ingredient is then homogeneously dispersed therein by stirring. The molten homogeneous mixture is then poured into a suitably sized mold, allowed to cool and thereby solidify.

Compositions suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or spray formulations containing in addition to the active ingredient such carriers as are known in the art to be appropriate.

Liquid formulations include solutions, suspensions and emulsions, for example, aqueous or water-propylene glycol solutions. For example, parenteral injection liquid preparations can be formulated as solutions of water-polyethylene glycol.

The compounds for use in the present invention may thus be formulated for parenteral administration (e.g. by injection, such as bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion bags or in multi-dose containers with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form, for constitution with a suitable vehicle, e.g., sterile, pyrogen-free water, before use, by sterile isolation from a sterile solid or by lyophilization from solution.

Aqueous solutions suitable for oral administration can be prepared by dissolving the active ingredient in water and adding the desired coloring, flavoring, stabilizing and thickening agents.

Aqueous suspensions suitable for oral administration can be prepared by dispersing the finely divided active ingredient in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, or other well-known suspending agents.

Also included are solid formulations designed to be converted, shortly before use, to liquid formulations for oral administration. Such liquid formulations include solutions, suspensions and emulsions. Such formulations may contain, in addition to the active ingredient, coloring agents, flavoring agents, stabilizers, buffers, artificial and natural sweeteners, dispersing agents, thickening agents, solubilizing agents, and the like.

For topical application to the epidermis, the compounds of the invention may be formulated as ointments, creams or lotions, or as a transdermal patch. For example, ointments and creams may be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents. Lotions may be formulated with an aqueous or oily base and will in general also contain one or more emulsifying agents, stabilizing agents, dispersing agents, suspending agents, thickening agents, or coloring agents.

Compositions suitable for topical administration in the oral cavity include lozenges (lozenes) containing the active ingredient in a flavored base, usually sucrose and acacia or tragacanth; lozenges (pastilles) containing the active ingredient in an inert base such as gelatin and glycerin or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier.

The solution or suspension can be applied directly to the nasal cavity by conventional means, for example, with a dropper, pipette or nebulizer. The composition may be in single or multiple dose form.

Administration to the respiratory tract may also be achieved by means of an aerosol formulation in which the active ingredient is packaged in a pressurised pack together with a suitable propellant, including a chlorofluorocarbon (CFC) such as dichlorodifluoromethane, trichlorofluoromethane or dichlorotetrafluoroethane, carbon dioxide or other suitable gas. The aerosol may also suitably contain a surfactant, such as lecithin. The dosage of the drug can be controlled by a metering valve.

Alternatively the active ingredient may be in the form of a dry powder, for example a powder mix of the compound with a suitable powder base such as lactose, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidone (PVP). The powder carrier can conveniently form a gel in the nasal cavity. The powder compositions may be presented in unit dose form, for example in capsules or cartridges (e.g. of gelatine, e.g. cuffed or cartridges), or in blister packs in which the powder may be administered by means of an inhaler.

In compositions for administration to the respiratory tract, including intranasal compositions, it is common for the compound to have a small particle size, for example on the order of 5 microns or less. Such particle sizes may be obtained by methods known in the art, for example by micronization.

If desired, compositions suitable for sustained release of the active ingredient may be employed.

The pharmaceutical preparation is preferably in unit dosage form. In such forms, the formulations are subdivided into unit doses containing appropriate quantities of the active ingredient. The unit dosage form may be a packaged preparation, wherein the sealed package contains discrete quantities of the preparation, e.g., packaged tablets, capsules, and powders in vials or ampoules. In addition, the unit dosage form may be a capsule, tablet, troche or lozenge (lozenge) per se, or may be any suitable number of such capsules, tablets and the like in any packaged form.

Tablets or capsules for oral administration and liquids for intravenous administration as well as continuous infusion are preferred compositions.

More detailed information on formulation and administration techniques can be found on the latest version of Remington's pharmaceutical sciences (Maack Publishing co., Easton, PA).

The amount of active ingredient in a unit dose formulation can vary depending on the particular application and the potency of the active ingredient, and can be adjusted from 0.01mg to about 0.1 g. For example, in pharmaceutical applications, the drug may be administered three times daily in a capsule of 0.01 to about 100mg, and the composition may also contain other compatible therapeutic agents as necessary.

Method of treatment

In therapeutic use, the compounds for use in the present invention are administered in an initial dose of 0.001mg/kg to 10mg/kg body weight per day. However, these dosages may vary depending on the patient's needs, the severity of the condition being treated and the compound being used, and generally, treatment will be initiated with smaller dosages less than the optimum dose of the compound, after which the dose is increased by small amounts to achieve optimum results, conveniently the total daily dosage may be subdivided into daily divided administrations if desired.

The pharmaceutical compositions of the present invention may also be used in combination with other drugs for the treatment of pain, Alzheimer's disease, multi-infarct dementia and stroke, including but not limited to morphine, gabapentin and the like. Accordingly, the present invention provides a drug for treating pain, alzheimer's disease, multi-infarct dementia and stroke, which is not only effective but also has no significant side effects, and another object of the present invention is to provide a drug having high safety for a special patient group such as the elderly, patients suffering from liver or renal function deterioration, or cardiovascular diseases.

Example (b):

synthesis scheme 1

Synthesis scheme 2

And (3) experimental operation:

the experimental process comprises the following steps:

6-hydroxymethylnicotinic acid (B2)

1.6 g of 6-hydroxymethyl-nicotinic acid methyl ester was dissolved in 30 ml of ethanol, and 1mol/L of aqueous sodium hydroxide solution was added dropwise with stirring to 2 ml of the reaction solution, and the mixture was stirred overnight at room temperature, TLC (dichloromethane: methanol 10: 1) showed that the starting material had substantially disappeared, the reaction solution was adjusted to neutral pH, and the mixture was evaporated to dryness under reduced pressure and passed through a column to give 1.2g of a white solid. 6-hydroxymethyl-N- (2-hydroxy-1-methyl-ethyl) -nicotinamide (B2)

6-hydroxymethylnicotinic acid (500 mg, 3.26 mmol), 1-hydroxybenzotriazole (0.88 g, 6.53 mmol), 1-ethyl- (3-dimethylaminopropyl) carbonyldiimine hydrochloride (1.25 g, 6.53 mmol) were added to a 15 ml N, N-dimethylformamide reaction flask, respectively, stirred at room temperature for 10 minutes under argon protection, R-aminopropanol (CAS:35320-23-1) (249 mg, 3.92 mmol) and N, N-diisopropylethylamine (1.69 g, 13.06 mmol) were added, the reaction mixture was stirred at room temperature overnight, TLC (dichloromethane: methanol 10: 1) showed substantial disappearance of the starting material, water and dichloromethane were added to the reaction solution, liquid separation was carried out, the organic phase was washed with water, and evaporated to dryness under reduced pressure on the column to obtain 250 mmol of a white solid.

Example 1

(R) -N- (1-hydroxypropyl-2-) -6- [3- (5-methyl-isoxazol-3-yl) [1,2,3] -triazolo [1,5-a ] quinazolin-5-oxy) methylene ] nicotinamide (03)

5-chloro-3- (5-methyl-isoxazol-3-yl) - [1,2,3] triazolo [1,5- α ] quinazoline (50 mg, 0.18 mmol) (A6, preparation reference Tetrahedron,2002,58,9973-9981) and 6-hydroxymethyl-N- (2-hydroxy-1-methyl-ethyl) -nicotinamide (73.6 mg, 0.35 mmol) were dissolved in ml of dried tetrahydrofuran, sodium tert-butoxide (33.6 mg, 0.35 mmol) was added in portions at zero DEG C for about 10 minutes, the reaction mixture was reacted at zero degrees C for 30 minutes, naturally warmed to room temperature for one hour, TLC (dichloromethane: methanol: 10: 1) showed substantial disappearance of the starting material, the reaction solution was evaporated to dryness under reduced pressure, 25 ml of dichloromethane and 30 ml of water were added, the organic phase was washed twice with water, dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure on the column to give 5 mm of a white solid with a yield of 29%.

¹H NMR(400MHz,DMSO-d6):9.04(d,1H J＝2.0),8.60(d,1H J＝8.4),8.43～8.39(m,1H),8.34(d,1H J＝8.0),8.29～8.24(m,1H),8.21～8.15(m,1H),7.91～7.83(m,2H),6.81(s,1H),5.86(s,2H),4.75(t,1H J＝6.4),4.05～3.98(m,1H),3.48～3.42(m,1H),3.37～3.31(m,1H),2.52(s,3H),1.12(d,3H J＝6.8)；LC-MS:m/z(ES+)for C₂₃H₂₁N₇O₄，460.20[M+1]⁺。

Following the experimental procedure described above in example 1, the following compounds were obtained:

Claims (10)

1. A compound shown as a formula I, a cis-trans isomer, an enantiomer, a diastereoisomer, a racemate, a solvate, a hydrate or pharmaceutically acceptable salt and ester thereof,

t represents C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-8 bicycloalkyl, C6-10 aryl, C3-7 heterocycloalkyl; preferably T represents a benzene ring.

Z represents a 5-membered heteroaromatic ring containing 1,2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulphur; the 5-membered heteroaromatic ring is optionally substituted with one or more substituents selected from the group consisting of: hydroxy, halogen, -R1, -OR1, -oc (o) R1, -NR2R3, CN, cyano (C1-6) alkyl-OR R2;

r1 represents C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkyl (C1-6) alkyl, cyano (C1-6) alkyl, C1-6 alkyl substituted by hydroxy or amino, and R1 is optionally mono-, di-or tri-fluorinated;

r2 or R3 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl or CF3, or R2 and R3 together with the nitrogen atom to which they are both attached form a 4-7 membered heteroaliphatic ring containing said nitrogen atom and one other heteroatom optionally selected from O, N and S, said heteroaliphatic ring being optionally substituted with one or more R1 groups;

preferably Z represents a5 membered heteroaromatic ring containing 1,2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulphur, of which up to 1 heteroatom is oxygen or sulphur and at least 1 oxygen or sulphur atom is also present when 1 heteroatom is a nitrogen atom, said 5 membered heteroaromatic ring being optionally substituted by one or more substituents selected from: C1-C4 alkyl, hydroxy, halogen, hydroxy or amino substituted C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoxy;

more preferably Z represents a 5-membered heteroaromatic ring containing 2 heteroatoms independently selected from oxygen, nitrogen and sulphur, and one heteroatom is oxygen or sulphur and the other atom is nitrogen; the 5-membered heteroaromatic ring is optionally substituted with one or more substituents selected from the group consisting of: c1-6 alkyl or hydroxy C1-6 alkyl.

Most preferably Z represents oxa-diazolyl, furyl, thienyl or isoxazolyl, said isoxazolyl being optionally substituted by one or more substituents selected from: h, C1-6 alkyl or hydroxy C1-6 alkyl.

A is-NR 2-; or A is a 5-membered heteroarylene group containing 1,2,3 or 4 heteroatoms independently selected from oxygen, nitrogen and sulfur and up to 1 of the heteroatoms is oxygen or sulfur; OR is a 6-membered heteroarylene group containing 1,2 OR 3 nitrogen atoms, OR the 5-OR 6-membered heteroarylene group is further optionally fused to a benzene OR pyridine ring, the 5-OR 6-membered heteroarylene group being optionally substituted by Rx and/OR Ry and/OR Rz, wherein Rx is halogen, -R1, -OR1, -OC (O) R1, -C (O) OR1, -NR2R3, -NR2C (O) R3, -OH, -CN, Ry is halogen, -R1, -OR1, -OC (O) R1, -NR2R3, -NR2R 2C (O) R3, OR CN, Rz is-R1, -OR1 OR-OC (O) R1, with the proviso that when A is a pyridine derivative, the pyridine ring is optionally in the form of an N-oxide; or a is phenylene optionally substituted with 1,2 or 3 groups independently selected from: halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-6 cycloalkyl;

preferably a represents a 5-membered heteroarylene group containing 1,2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulfur and up to 1 of the heteroatoms being oxygen or sulfur, or a 6-membered heteroarylene group or phenylene group containing 1,2 or 3 nitrogen atoms; the 5-membered heteroarylene group, the 6-membered heteroarylene group, and the phenylene group are optionally substituted with a substituent independently selected from the group consisting of: halogen, cyano, C1-6 alkyl;

more preferably a represents phenylene, pyridylene, isoxazolylene; optionally substituted with 1,2 or 3 substituents independently selected from: halogen, cyano, C1-6 alkyl.

Y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is selected from: h; c1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, halogen, halo-C1-6 alkoxy, hydroxy, C1-6 alkoxy, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, nitro and C1-6 alkyl-S (O)₂-；

Y2 is selected from: h; c1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, halogen, halo-C1-6 alkoxy, hydroxy, C1-6 alkoxy, cycloalkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, nitro and C1-6 alkyl-S (O)₂-；

Heteroaryl, or heteroaryl substituted with 1-4 substituents independently selected from: acetamido, acetyl, acetylamino, acylamino, amino, carboxyl, cyano, halogen, halo-C1-6 alkoxy, halo-C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl,c1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, nitro and C1-6 alkyl-S (O)₂-；

Cycloalkyl, or cycloalkyl substituted with 1 to 4 substituents independently selected from: acetamido, acetyl, acetylamino, acylamino, amino, carboxy, cyano, halogen, halo-C1-6 alkoxy, halo-C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, nitro and C1-6 alkyl-S (O)₂-；

Heterocyclyl, or heterocycloalkyl substituted with 1-4 substituents independently selected from: acetamido, acetyl, acetylamino, acylamino, amino, carboxy, cyano, halogen, halo-C1-6 alkoxy, halo-C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, nitro and C1-6 alkyl-S (O)₂-；

Or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl, the heterocycloalkyl group containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

y3, Y4 are independently selected from: hydrogen, C1-C6 alkyl, SO₂-C1-C6 alkyl, cycloalkyl, and heterocyclyl, optionally substituted with 1-4 substituents independently selected from the group consisting of: halogen, cyano, hydroxy, C1-C6 alkyl and C1-C6 alkoxy,

or wherein Y3, Y4 together with the nitrogen atom to which they are attached form a heterocyclic group, which heterocyclic group is optionally substituted with 1-4 substituents independently selected from the group consisting of: halogen, cyano, hydroxy, oxo, C1-C6 alkyl, and C1-C6 alkoxy.

2. The compound of claim 1, having the following general formula II:

wherein

R4 is C1-C4 alkyl or hydroxy-substituted C1-C4 alkyl;

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is selected from H, C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

Y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: amino, hydroxy, C1-6 alkoxy, cycloalkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-, and C1-6 alkyl-S (O)₂-；

C5-C6 heteroaryl having 1-3 heteroatoms selected from N, O or S, C5-C6 heteroaryl substituted with C1-6 alkyl having 1-3 heteroatoms selected from N, O or S;

c3-6 cycloalkyl, C3-6 cycloalkyl substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl, (C1-6 alkyl ) N-, (C1-6 alkyl, H) N-and C1-6 alkyl-S (O)₂-；

C4-C6-heterocyclyl containing 1-3 heteroatoms selected from N, O or S, C4-C6 heterocycloalkyl containing 1-3 heteroatoms selected from N, O or S substituted with 1-4 substituents independently selected from: amino, hydroxy-C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkyl and C1-6 alkyl-S (O)₂-；

Or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

y3, Y4 are independently selected from: hydrogen, C1-C6 alkyl, SO₂-C1-C6 alkyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group.

3. The compound of claim 2,

r4 is selected from methyl and hydroxy-substituted methyl;

y1 is selected from H and C1-6 alkyl.

4. The compound of claim 2, having the following general formula ii:

y is-NY 1Y2 or-NH-NY 3Y 4;

y1 is H or C1-6 alkyl;

y2 is selected from C1-6 alkyl; c1-6 alkyl substituted with 1-5 substituents independently selected from the group consisting of: hydroxy and C1-6 alkoxy;

c3-6 cycloalkyl; c3-6 cycloalkyl substituted with 1-4 substituents which are hydroxy;

or Y1, Y2 together with the N atom to which they are attached form a 4-6 membered heterocyclyl containing, in addition to the nitrogen atom, zero, one or more heteroatoms selected from O and S, and the S atom may be in its oxide form;

y3 and Y4 are independently selected from: hydrogen and methyl, Y3 and Y4 form together with the nitrogen atom to which they are attached a heterocyclic group.

5. The compound of claim 4, wherein Y1 is H or methyl.

6. The compound of claim 4,

y1 is H or methyl;

y2 is selected from hydroxy n-propanol, isopropyl, hydroxycyclopentyl, methyl, ethyl, methoxyethyl, or hydroxyethoxy;

or Y3 and Y4 together with the nitrogen atom to which they are attached form a morpholinyl group;

y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclyl selected from morpholinyl and piperidinyl.

7. The compound of claim 4,

y1 is H or methyl;

y2 is selected from 1-hydroxy n-propanol, 2-hydroxycyclopentyl, methyl, ethyl, 2-methoxyethyl or hydroxyethoxy;

or Y3 and Y4 together with the nitrogen atom to which they are attached form morpholin-4-yl;

y3 and Y4 are independently selected from: hydrogen and methyl, or Y3 and Y4 together with the nitrogen atom to which they are attached form a heterocyclic group selected from morpholin-4-yl and piperidin-1-yl.

8. The compound of any one of claims 1-7, independently selected from:

9. the use of a compound according to any one of claims 1 to 8 for the preparation of a medicament for the treatment or prophylaxis of: pain, alzheimer's disease, multi-infarct dementia and stroke.

10. A process for the preparation of a compound as claimed in any one of claims 1 to 8, selected from any one of the following:

a) reacting a compound of formula (IV)

Andreacting to obtain a compound of formula (1-3), wherein G and W are selected from Cl, Br, I, OH, OTs, OTf and OMs, R5 is alkyl, methyl, ethyl, tert-butyl, benzyl, etc.; wherein Z, Y, A is as defined in claims 1-8;

then reacting the compound of formula (1-3)

With Y, wherein Z, Y, A is as defined in claims 1-8; or

b) Reacting a compound of formula (1-4):

with Y, wherein Z, Y, A is as defined in claims 1-8;

c) saponifying a compound of formula (1-3) to a compound of formula (1-4) and subsequently reacting with Y, wherein Z, Y, A is as defined in claims 1-8; or

d) Formula (II)Compounds and formulaeReaction of the compounds.