CN107259580B - The preparation method of one kind of multiple minerals vitamin preparations - Google Patents
The preparation method of one kind of multiple minerals vitamin preparations Download PDFInfo
- Publication number
- CN107259580B CN107259580B CN201710581517.8A CN201710581517A CN107259580B CN 107259580 B CN107259580 B CN 107259580B CN 201710581517 A CN201710581517 A CN 201710581517A CN 107259580 B CN107259580 B CN 107259580B
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- vitamin
- preparation
- piller
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to the preparation methods of one kind of multiple minerals vitamin preparations, belong to nutritional health food field.Specific steps include the pretreatment of vitamin D, the preparation of vitamin D embedded particles, the pretreatment of divalent manganesetion, the preparation of divalent manganesetion embedded particles, the pretreatment of mineral matter element and preparation synthesis；The several mineral materials vitamin preparation prepared by this method, vitamin D and divalent manganesetion therein is made to be effectively isolated with the other multi mineral prime elements added in product, avoid interference of the external environment to drug simultaneously, effectively enhance the stability of preparation, give full play to its pharmaceutical properties, multi mineral prime element is added, ensures that human body takes in enough required nutrients.
Description
Technical field
The invention belongs to nutritional health food field, specifically, being related to the system of one kind of multiple minerals vitamin preparations
Preparation Method.
Background technology
With the development of science and technology and the raising of people's health consciousness, daily active nutritive health-care food for supplementing have been formed
A kind of new trend takes in nutrient deficiency or the certain diseases of prevention to supplement three meals in a day.Numerous studies show vitamin, mineral
Matter and it can effectively prevent disease with their nutrient prime replenishers as main component, vitamin and mineral is maintenance flesh
Body eubolism and the essential important substance of health, the two are to form the important composition of a variety of coenzyme and hormone, are lacked
Reactive volt-ampere hour can lead to dysbolism, and cause a variety of diseases.
Several mineral materials vitamin preparation, containing multi mineral prime element and vitamin, can be supplemented as nutritional supplement
The deficiency of body vitamin and micro macroelement, for preventing the various diseases caused by vitamin and indispensable element lack
Disease.Wherein vitamin D is a very unique member in all bioactive substances, has a variety of effects, not only to human body
Alcium and phosphor metabolization and sclerotin calcification play an important role, and each histocyte has wide application to whole body, with various important diseases
Have substantial connection, but since vitamin D influences other materials in illumination, air, humidity and product, in process of production and
The product made in products-supply using the method for conventional formulation, vitamin D are influenced by factors above, and content significantly drops
It is low, make people's vitamin D intake deficiency that the due effect of nutritional supplement be not achieved, and air, humidity are to trace element manganese
And other materials influence in product, easily make bivalent manganese cycling of elements into manganese dioxide, the manganese during manufactured products-supply
Element is influenced by factors above, and product appearance character is caused black splotch easily occur, the quality of product by Different Effects,
It is unfavorable for absorption of human body.
Therefore, it is necessary to improve the stability of vitamin D in several mineral materials vitamin preparation, human body is improved in product
The absorption rate of vitamin D；It is necessary to protect divalent manganesetion in nutritional preparation, it is avoided to be oxidized to two under alkaline condition
Manganese oxide is influenced so as to product quality.
Invention content
In order to solve the problems, such as background technology, the present invention provides the systems of one kind of multiple minerals vitamin preparations
Preparation Method by carrying out embedding treatment to vitamin D and divalent manganesetion, makes itself and other several mineral materials for being added in product
Element is effectively isolated, and effectively enhances the stability of preparation.
To achieve the above object, the present invention is achieved through the following technical solutions：
The preparation method of one kind of multiple minerals vitamin preparations, includes the following steps：
1) pretreatment of vitamin D：Microcrystalline cellulose is given birth to dimension into the piller of 10 mesh with 3%HPMC solution mixing systems
95% alcohol 100 of plain D oil solutions:Spray is done on piller, treating that piller fully absorbs vitamin D to saturation state after 1 dilution
It is dry for use；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, is coated the piller for absorbing vitamin D, dried for standby；
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, it is dry further by mixture A and adhesive 3%HPMC solution mixing systems into 10 mesh pillers
For use；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent B with water is uniformly mixed, is made
The coating solution of solid content 15% is coated 10 mesh piller of bivalent manganese, dried for standby；
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) preparation synthesizes：By the vitamin D embedded particles of 160-180 parts by weight, the divalent manganesetion packet of 10-15 parts by weight
Bury particle, the mineral matter element pretreatment piller of 30-35 parts by weight is uniformly mixed, tabletting or encapsulated use.
Further, coating agent A described in step 2) be the titanium dioxide of 10-15 parts by weight, the soybean phosphorus of 5-10 parts by weight
Fat, the Sunset yellow aluminum lake of 3-8 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, the talcum powder of 10-20 parts by weight, 5-10 weights
Measure the polyethylene glycol of part, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight indigo aluminum lake.
Further, coating agent B described in step 4) be the titanium dioxide of 10-15 parts by weight, the brilliant blue aluminium color of 3-8 parts by weight
Shallow lake, the soybean lecithin of 5-10 parts by weight, the copper sulphate of 2-5 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, 10-20 parts by weight
Talcum powder, the polyethylene glycol of 5-10 parts by weight, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight Fancy red aluminum lake.
Beneficial effects of the present invention：
The present application is handled vitamin D and divalent manganesetion by packaging technique, effective protection vitamin D and
Divalent manganesetion is not illuminated by the light, in air, humidity and product other materials influence；Soybean lecithin is added in, makes coating agent uniform
Densification, covered effect is good, while soybean lecithin can promote human metabolism, promotes the suction of vitamin D and each nutrient
It receives；Several mineral materials vitamin preparation by Cotton seeds, make vitamin D and bivalent manganese from added in product it is other more
Kind mineral matter element is effectively isolated, while avoid interference of the external environment to drug, effectively enhances the stability of preparation, fully
Play its pharmaceutical properties；Multi mineral prime element is added, ensures that human body takes in enough required nutrients.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work, all
Belong to the scope of protection of the invention.
The preparation method of one kind of multiple minerals vitamin preparations, includes the following steps：
1) pretreatment of vitamin D：Microcrystalline cellulose is given birth to dimension into the piller of 10 mesh with 3%HPMC solution mixing systems
95% alcohol 100 of plain D oil solutions:Spray is done on piller, treating that piller fully absorbs vitamin D to saturation state after 1 dilution
It is dry for use；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, is coated the piller for absorbing vitamin D, dried for standby；
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, it is dry further by mixture A and adhesive 3%HPMC solution mixing systems into 10 mesh pillers
For use；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent B with water is uniformly mixed, is made
The coating solution of solid content 15% is coated 10 mesh piller of bivalent manganese, dried for standby；
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby；
6) preparation synthesizes：By the vitamin D embedded particles of 160-180 parts by weight, the divalent manganesetion packet of 10-15 parts by weight
Bury particle, the mineral matter element pretreatment piller of 30-35 parts by weight is uniformly mixed, tabletting or encapsulated use.
Further, coating agent A described in step 2) be the titanium dioxide of 10-15 parts by weight, the soybean phosphorus of 5-10 parts by weight
Fat, the Sunset yellow aluminum lake of 3-8 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, the talcum powder of 10-20 parts by weight, 5-10 weights
Measure the polyethylene glycol of part, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight indigo aluminum lake.
Further, coating agent B described in step 4) be the titanium dioxide of 10-15 parts by weight, the brilliant blue aluminium color of 3-8 parts by weight
Shallow lake, the soybean lecithin of 5-10 parts by weight, the copper sulphate of 2-5 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, 10-20 parts by weight
Talcum powder, the polyethylene glycol of 5-10 parts by weight, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight Fancy red aluminum lake.
Further, the mass ratio of microcrystalline cellulose and 3%HPMC solution is 3.5-4 in step 1):1；It is mixed in step 3)
The mass ratio 3.5-4 of object A and adhesive 3%HPMC solution:1.
Further, the art for coating condition in step 2) be 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure
2.0bar, coating pan rotating speed 5rpm, coating flow velocity 80-100g/min.
Further, the art for coating condition in step 4) be 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure
2.0bar, coating pan rotating speed 8rpm, coating flow velocity 100-120g/min.
Embodiment 1
One kind of multiple minerals vitamin preparations and preparation method thereof, specific preparation process is as follows：
1) pretreatment of vitamin D：It is 3.5 in mass ratio by microcrystalline cellulose and 3%HPMC solution:1 is mixed and made into 10
Purpose piller, by 95% alcohol 100 of vitamin D oil solution:1 dilution after spray on piller, treat piller fully absorb dimension life
Plain D is to saturation state, dried for standby；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, in 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
The piller for absorbing vitamin D is coated under conditions of coating flow velocity 80-100g/min, dried for standby, coating agent A's
Composition is as shown in table 1：
The composition of 1 coating agent A of table
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, further by mixture A and adhesive 3%HPMC solution in mass ratio 3.5:1 is mixed
10 mesh pillers, dried for standby；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent with water is uniformly mixed, is made solid
The coating solution of content 15%, in 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed
10 mesh piller of bivalent manganese is coated under conditions of 8rpm, coating flow velocity 100-120g/min, dried for standby, coating agent B
Composition it is as shown in table 2：
The composition of 2 coating agent B of table
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) preparation synthesizes：By the vitamin D embedded particles of 160 parts by weight, 10 parts by weight divalent manganesetion embedded particles,
The mineral matter element pretreatment piller of 30 parts by weight is uniformly mixed, and one kind of multiple minerals vitamins are made in tabletting or encapsulated
Preparation.
Embodiment 2
One kind of multiple minerals vitamin preparations and preparation method thereof, specific preparation process is as follows：
1) pretreatment of vitamin D：It is 3.8 in mass ratio by microcrystalline cellulose and 3%HPMC solution:1 is mixed and made into 10
Purpose piller, by 95% alcohol 100 of vitamin D oil solution:1 dilution after spray on piller, treat piller fully absorb dimension life
Plain D is to saturation state, dried for standby；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, in 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
The piller for absorbing vitamin D is coated under conditions of coating flow velocity 80-100g/min, dried for standby, coating agent A's
Composition is as shown in table 1：
The composition of 1 coating agent A of table
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, further by mixture A and adhesive 3%HPMC solution in mass ratio 3.8:1 is mixed
10 mesh pillers, dried for standby；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent with water is uniformly mixed, is made solid
The coating solution of content 15%, in 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed
10 mesh piller of bivalent manganese is coated under conditions of 8rpm, coating flow velocity 100-120g/min, dried for standby, coating agent B
Composition it is as shown in table 2：
The composition of 2 coating agent B of table
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) by the vitamin D embedded particles of 170 parts by weight, the divalent manganesetion embedded particles of 12 parts by weight, 33 parts by weight
Mineral matter element pretreatment piller be uniformly mixed, one kind of multiple minerals vitamin preparations are made in tabletting or encapsulated.
Embodiment 3
One kind of multiple minerals vitamin preparations and preparation method thereof, specific preparation process is as follows：
1) pretreatment of vitamin D：It is 4 in mass ratio by microcrystalline cellulose and 3%HPMC solution:1 is mixed and made into 10 mesh
Piller, by 95% alcohol 100 of vitamin D oil solution:Spray is on piller, treating that piller fully absorbs vitamin D after 1 dilution
To saturation state, dried for standby；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, in 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
The piller for absorbing vitamin D is coated under conditions of coating flow velocity 80-100g/min, dried for standby, coating agent A's
Composition is as shown in table 1：
The composition of 1 coating agent A of table
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, further by mixture A and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10
Mesh piller, dried for standby；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent with water is uniformly mixed, is made solid
The coating solution of content 15%, in 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed
10 mesh piller of bivalent manganese is coated under conditions of 8rpm, coating flow velocity 100-120g/min, dried for standby, coating agent B
Composition it is as shown in table 2：
The composition of 2 coating agent B of table
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) preparation synthesizes：By the vitamin D embedded particles of 180 parts by weight, 15 parts by weight divalent manganesetion embedded particles,
The mineral matter element pretreatment piller of 35 parts by weight is uniformly mixed, and one kind of multiple minerals vitamins are made in tabletting or encapsulated
Preparation.
Effect analysis：
Adult's gastrointestinal system is from the food of the 1mg containing manganese to radiolabeled54The uptake of Mn, adult male and women
It is (1.35 ± 0.51) % and (3.55 ± 2.11) % respectively.Young woman takes in after 0.3mg manganese within 10d storing for manganese in vivo
Amount is about (5.0 ± 3.1) %.And in the present invention, several mineral materials vitamin preparation of the gastrointestinal system from the 1mg containing manganese of being grown up
In to radiolabeled54The uptake of Mn, adult male and women be respectively (2.65 ± 0.53) % and (5.55 ±
2.01) %.
The present application first pre-processes vitamin D and divalent manganesetion, then is coated operation, in pretreatment
The HPMC of proper proportion is added in, makes the piller shape to be formed uniform, surface rounding；Using HPMC as film forming in conventional coating agents
Agent, but it is larger as the clothing film porosity that film forming agent is formed using HPMC, and barrier property is relatively poor, and film forming agent polyethylene
Alcohol viscosity is larger, and form a film clothing film cracky, and production is difficult to control, the present invention first with HPMC to vitamin D and divalent manganesetion into
Row pretreatment, then be polyvinyl alcohol with film forming agent and coating solution containing soybean lecithin is coated, soybean lecithin has fine
Emulsifiability, dispersion performance, wettability and pick resistance, the addition of proper proportion soybean lecithin improves polyvinyl alcohol
The viscosity problem of coating solution, while make each component of coating agent is fabulous to be dispersed in solution system, form point of stable homogeneous
System is dissipated, sedimentation, the layering of coating agent in coating process is avoided, is coated the problems such as uneven；Since polyvinyl alcohol and HPMC have pole
Good compatibility cementability, piller first pass through HPMC pretreatments and are coated operation again, and fabulous enhances coating agent and piller
Compatibility, make coating stable and firm, it is not easily to fall off；Iron and calcium can hinder the absorption of manganese to a certain extent, in the coating agent of manganese
The copper of proper proportion is added in component, the defect can be overcome, promote the absorption of manganese；Several mineral materials dimension by Cotton seeds
Raw element preparation, makes vitamin D and divalent manganesetion are effectively isolated with the other multi mineral prime elements added in product, keeps away simultaneously
Exempt from interference of the external environment to drug, effectively enhance the stability of preparation, give full play to its pharmaceutical properties；Add multi mineral
Prime element ensures that human body takes in enough required nutrients.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (4)
1. the preparation method of one kind of multiple minerals vitamin preparations, which is characterized in that the several mineral materials vitamin system
The preparation method of agent includes the following steps：
1）The pretreatment of vitamin D：By microcrystalline cellulose with 3%HPMC solution mixing systems into the piller of 10 mesh, by vitamin D oil
95% alcohol 100 of solution:Spray on piller, treating that piller fully absorbs vitamin D to saturation state, treat by drying after 1 dilution
With；
2）The preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, solid content is made
15% coating solution is coated the piller for absorbing vitamin D, dried for standby；
3）The pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio 2:1 is mixed
Mixture A is obtained after conjunction, further by mixture A and adhesive 3%HPMC solution mixing systems into 10 mesh pillers, dried for standby；
4）The preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent B with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, is coated 10 mesh piller of bivalent manganese, dried for standby；
5）The pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, the ferrous gluconate of 30-40 parts by weight, 20-
The zinc gluconate of 30 parts by weight, the sodium selenite of 0 .01-0 .03 parts by weight, 10-15 parts by weight magnesia be uniformly mixed,
Mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers, dry
For use；
6）Preparation synthesizes：By the divalent manganesetion embedding of the vitamin D embedded particles of 160-180 parts by weight, 10-15 parts by weight
Grain, 30-35 parts by weight mineral matter element pretreatment piller be uniformly mixed, tabletting or encapsulated use；
Wherein, step 2）Described in coating agent A for the titanium dioxide of 10-15 parts by weight, the soybean lecithin of 5-10 parts by weight, 3-8
The Sunset yellow aluminum lake of parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, the talcum powder of 10-20 parts by weight, 5-10 parts by weight
Polyethylene glycol, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight indigo aluminum lake；
Step 4）Described in coating agent B for the titanium dioxide of 10-15 parts by weight, the Brilliant blue aluminum lake of 3-8 parts by weight, 5-10 weight
Part soybean lecithin, the copper sulphate of 2-5 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, 10-20 parts by weight talcum powder, 5-
The polyethylene glycol of 10 parts by weight, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight Fancy red aluminum lake.
2. the preparation method of one kind of multiple minerals vitamin preparations according to claim 1, which is characterized in that step 1）
The mass ratio of middle microcrystalline cellulose and 3%HPMC solution is 3.5-4:1；Step 3）Middle mixture A and adhesive 3%HPMC solution
Mass ratio 3.5-4:1.
3. the preparation method of one kind of multiple minerals vitamin preparations according to claim 1, which is characterized in that step 2）
In art for coating condition for 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
It is coated flow velocity 80-100g/min.
4. the preparation method of one kind of multiple minerals vitamin preparations according to claim 1, which is characterized in that step 4）
In art for coating condition for 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 8rpm,
It is coated flow velocity 100-120g/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710581517.8A CN107259580B (en) | 2017-07-17 | 2017-07-17 | The preparation method of one kind of multiple minerals vitamin preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710581517.8A CN107259580B (en) | 2017-07-17 | 2017-07-17 | The preparation method of one kind of multiple minerals vitamin preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107259580A CN107259580A (en) | 2017-10-20 |
| CN107259580B true CN107259580B (en) | 2018-06-19 |
Family
ID=60072959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710581517.8A Active CN107259580B (en) | 2017-07-17 | 2017-07-17 | The preparation method of one kind of multiple minerals vitamin preparations |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107259580B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870584A (en) * | 2020-08-25 | 2020-11-03 | 无限极（中国）有限公司 | Composition beneficial to bone health promotion and application thereof |
| CN113368068B (en) * | 2021-05-21 | 2022-08-02 | 北京斯利安药业有限公司 | Embedded particles and preparation method and application thereof |
| CN113180245A (en) * | 2021-06-07 | 2021-07-30 | 湖北人缘堂医药生物工程有限公司 | Production method of multi-vitamin mineral tablets |
| CN115006363A (en) * | 2022-06-23 | 2022-09-06 | 上海信谊万象药业股份有限公司 | A kind of oyster calcium carbonate chewable tablet and preparation method thereof |
| CN116548620A (en) * | 2023-04-23 | 2023-08-08 | 山东新硒望生态农业科技有限公司 | Novel K2 selenium multidimensional tablet and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495163B1 (en) * | 1994-07-12 | 2002-12-17 | Bpsi Holdings, Inc. | Moisture barrier film coating composition, method and coated form |
| CN1206267C (en) * | 1999-07-09 | 2005-06-15 | Bpsi控股公司 | Film coatings and film coating compositions based on polyvinyl alcohol |
| CN101401809A (en) * | 2008-11-12 | 2009-04-08 | 杭州民生药业集团有限公司 | Preparation for composition of vitamin and mineral matter |
| CN102319263A (en) * | 2011-08-17 | 2012-01-18 | 江门市新会区光华生物科技有限公司 | Film coated tablets containing a plurality of vitamins and mineral matters, and its preparation process |
| CN102512445A (en) * | 2011-12-29 | 2012-06-27 | 杭州海王生物工程有限公司 | Multivitamin mineral preparation |
| CN103316056A (en) * | 2013-06-24 | 2013-09-25 | 江苏鹏鹞药业有限公司 | Radix isatidis coating dispersible tablet and preparation method thereof |
| CN106420808A (en) * | 2015-08-11 | 2017-02-22 | 北京远方通达医药技术有限公司 | Preparation containing vitamin D3 and calcium carbonate and preparation method for preparation |
-
2017
- 2017-07-17 CN CN201710581517.8A patent/CN107259580B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495163B1 (en) * | 1994-07-12 | 2002-12-17 | Bpsi Holdings, Inc. | Moisture barrier film coating composition, method and coated form |
| CN1206267C (en) * | 1999-07-09 | 2005-06-15 | Bpsi控股公司 | Film coatings and film coating compositions based on polyvinyl alcohol |
| CN101401809A (en) * | 2008-11-12 | 2009-04-08 | 杭州民生药业集团有限公司 | Preparation for composition of vitamin and mineral matter |
| CN102319263A (en) * | 2011-08-17 | 2012-01-18 | 江门市新会区光华生物科技有限公司 | Film coated tablets containing a plurality of vitamins and mineral matters, and its preparation process |
| CN102512445A (en) * | 2011-12-29 | 2012-06-27 | 杭州海王生物工程有限公司 | Multivitamin mineral preparation |
| CN103316056A (en) * | 2013-06-24 | 2013-09-25 | 江苏鹏鹞药业有限公司 | Radix isatidis coating dispersible tablet and preparation method thereof |
| CN106420808A (en) * | 2015-08-11 | 2017-02-22 | 北京远方通达医药技术有限公司 | Preparation containing vitamin D3 and calcium carbonate and preparation method for preparation |
Non-Patent Citations (2)
| Title |
|---|
| 多种矿物质维生素D胶囊;佚名;《http://www2.yy99.net:8089/zhaoshang/384801.shtml》;20170326 * |
| 多种维生素矿物质片;佚名;《http://www2.yy99.net:8089/zhaoshang/384802.shtml》;20170326 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107259580A (en) | 2017-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107259580B (en) | The preparation method of one kind of multiple minerals vitamin preparations | |
| CN103689388A (en) | Solanum tuberdsm noodles and manufacturing method thereof | |
| KR100649692B1 (en) | Tablet type milk including sea grass and manufacturing method thereof | |
| CN106727675A (en) | A kind of calcium-replenishing soft capsule and preparation method thereof | |
| CN106165905B (en) | A kind of calcium adds vitamine soft capsule and preparation method | |
| CN106491565A (en) | A kind of vitamin C zincification sustained-release pellet preparation and preparation method thereof | |
| CN108208741A (en) | A kind of functionality edible salt, Cardia Salt and savory flavor and preparation method thereof | |
| CN110477178A (en) | Chlorella pyrenoidosa collagen peptide gel candy and preparation method thereof | |
| CN105533450A (en) | Nutritional health-care rice flour and preparation method thereof | |
| CN105211859A (en) | A kind of agate coffee wheat seeding oral tablet and preparation method thereof | |
| CN105380097A (en) | Nutritive noodles containing wheat oligopeptides and okra and production process | |
| CN111374204A (en) | Preparation method of camellia oil DHA algae oil gel candy | |
| CN103494052B (en) | A kind of polypeptide infant calcium supplement instant granule and preparation method thereof | |
| CN109198143A (en) | Have effects that the compound anthocyanidin pressed candy of hyperconcetration biology for preventing and treating cancer and preparation method | |
| CN103919119A (en) | Anti-oxidative double-glue reishi shell-broken spore powder and preparation method thereof | |
| CN101856117A (en) | Donkey-hide gelatin coated rice | |
| CN104719895A (en) | Grape polyphenol microcapsule health care product and preparation method thereof | |
| CN107929259A (en) | A kind of soft capsule with different disintegration modes and preparation method thereof | |
| CN106578812A (en) | Solid health-caring beverage and preparation method of same | |
| CN106360626A (en) | Preparation method of organic nutrient low-sodium salt for children | |
| KR100580935B1 (en) | Calcium preparation using calcined algae, calcium fortified rice and manufacturing method | |
| CN102379311B (en) | Ecological rice nutrient solution production method | |
| CN108935902A (en) | Have effects that the compound anthocyanidin pressed candy of hyperconcetration biology for improving skin quality and preparation method | |
| CN119564633A (en) | Processing technology of vitamin ginseng zinc capsule | |
| CN2774511Y (en) | Vitamin U belladonna aluminum II micro pill |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |