CN107186637B - Medical antibacterial tweezers with easily-replaceable heads - Google Patents
Medical antibacterial tweezers with easily-replaceable heads Download PDFInfo
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- CN107186637B CN107186637B CN201710634976.8A CN201710634976A CN107186637B CN 107186637 B CN107186637 B CN 107186637B CN 201710634976 A CN201710634976 A CN 201710634976A CN 107186637 B CN107186637 B CN 107186637B
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- forceps
- tweezers
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 45
- 239000000945 filler Substances 0.000 claims abstract description 16
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 9
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 9
- 239000004743 Polypropylene Substances 0.000 claims abstract description 6
- -1 polypropylene Polymers 0.000 claims abstract description 6
- 229920001155 polypropylene Polymers 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000011247 coating layer Substances 0.000 claims abstract description 3
- 229920000128 polypyrrole Polymers 0.000 claims description 34
- 239000002071 nanotube Substances 0.000 claims description 33
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 15
- 238000001291 vacuum drying Methods 0.000 claims description 15
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 14
- 229960003638 dopamine Drugs 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 claims description 7
- 229940012189 methyl orange Drugs 0.000 claims description 7
- 239000000178 monomer Substances 0.000 claims description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 238000000967 suction filtration Methods 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 238000003786 synthesis reaction Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- ULTHEAFYOOPTTB-UHFFFAOYSA-N 1,4-dibromobutane Chemical compound BrCCCCBr ULTHEAFYOOPTTB-UHFFFAOYSA-N 0.000 claims description 4
- KJDRSWPQXHESDQ-UHFFFAOYSA-N 1,4-dichlorobutane Chemical compound ClCCCCCl KJDRSWPQXHESDQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003973 paint Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- KNKRKFALVUDBJE-UHFFFAOYSA-N 1,2-dichloropropane Chemical compound CC(Cl)CCl KNKRKFALVUDBJE-UHFFFAOYSA-N 0.000 claims description 3
- IBODDUNKEPPBKW-UHFFFAOYSA-N 1,5-dibromopentane Chemical compound BrCCCCCBr IBODDUNKEPPBKW-UHFFFAOYSA-N 0.000 claims description 3
- LBKDGROORAKTLC-UHFFFAOYSA-N 1,5-dichloropentane Chemical compound ClCCCCCCl LBKDGROORAKTLC-UHFFFAOYSA-N 0.000 claims description 3
- HCILJBJJZALOAL-UHFFFAOYSA-N 3-(3,5-ditert-butyl-4-hydroxyphenyl)-n'-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyl]propanehydrazide Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)NNC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 HCILJBJJZALOAL-UHFFFAOYSA-N 0.000 claims description 3
- JKIJEFPNVSHHEI-UHFFFAOYSA-N Phenol, 2,4-bis(1,1-dimethylethyl)-, phosphite (3:1) Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC=C1OP(OC=1C(=CC(=CC=1)C(C)(C)C)C(C)(C)C)OC1=CC=C(C(C)(C)C)C=C1C(C)(C)C JKIJEFPNVSHHEI-UHFFFAOYSA-N 0.000 claims description 3
- BGYHLZZASRKEJE-UHFFFAOYSA-N [3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCC(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 BGYHLZZASRKEJE-UHFFFAOYSA-N 0.000 claims description 3
- SSDSCDGVMJFTEQ-UHFFFAOYSA-N octadecyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 SSDSCDGVMJFTEQ-UHFFFAOYSA-N 0.000 claims description 3
- 238000000576 coating method Methods 0.000 abstract description 13
- 239000011248 coating agent Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- JUJFMLWMVKDEHI-UHFFFAOYSA-N 1-bromo-1,2-dichloropropane Chemical compound CC(Cl)C(Cl)Br JUJFMLWMVKDEHI-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000001132 ultrasonic dispersion Methods 0.000 description 2
- 239000000783 alginic acid Chemical group 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 229920000615 alginic acid Chemical group 0.000 description 1
- 150000004781 alginic acids Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
- B25B—TOOLS OR BENCH DEVICES NOT OTHERWISE PROVIDED FOR, FOR FASTENING, CONNECTING, DISENGAGING OR HOLDING
- B25B9/00—Hand-held gripping tools other than those covered by group B25B7/00
- B25B9/02—Hand-held gripping tools other than those covered by group B25B7/00 without sliding or pivotal connections, e.g. tweezers, onepiece tongs
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Materials For Medical Uses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention provides medical antibacterial forceps with easily replaceable heads, which comprise two elastic forceps handles and two forceps heads, wherein one ends of the two elastic forceps handles are fixed together, the other ends of the two elastic forceps handles are mutually spaced to form free ends, the free ends of the two elastic forceps handles are respectively provided with an accommodating cavity and clamping grooves communicated with the accommodating cavity on two symmetrical side surfaces, the two forceps heads respectively comprise a forceps head front part and a forceps head rear part, the rear parts of the forceps heads are fixedly provided with two elastic arms, the free ends of the two elastic arms are respectively provided with bulges corresponding to the clamping grooves, the forceps heads are detachably arranged on the forceps handles, and the free ends of the two elastic arms are respectively provided with bulges corresponding to the clamping grooves; the two elastic forceps handles are made of the following raw materials in parts by weight: 80-90 parts of polypropylene, 10-15 parts of antibacterial filler and 1-2 parts of antioxidant; the medical antibacterial forceps with the easily replaceable heads provided by the invention has the advantages that the heads are easily replaceable, and the antibacterial property and the biocompatibility are good; the surface coating has the luminous coating layer, can give out light, finds easily in the dark place, also is suitable for playing the light filling effect when using tweezers in the dark place, can not produce the shade.
Description
Technical Field
The invention relates to the technical field of clamping tools, in particular to a pair of medical antibacterial tweezers with easily replaceable heads.
Background
Tweezers are a common auxiliary tool, and are widely applied to the industries of medicine, cosmetology, electronics and the like because the tweezers can accurately and conveniently clamp objects.
The existing tweezers comprise tweezers heads and corresponding fixed ends, after long-term use, the tweezers heads are most easily damaged, and the tweezers heads which are most easily worn are damaged once, so that the whole tweezers are scrapped, and materials are wasted; in addition, due to the difference in the product to be held and its own specification, tweezers of different specifications must be prepared, which further increases the cost. As an improvement to the above technical problem, tweezers with replaceable tweezer heads are provided in the market, however, such tweezers usually need to be fixed by screws, are relatively complicated, and are inconvenient to replace. In addition, the tweezers in the prior art have poor antibacterial performance and are not suitable for long-term medical use.
Chinese patent invention patent, application publication number: CN102476359A discloses a pair of tweezers, which comprises a main body with two elastic tweezers handles and two tweezers heads, wherein each tweezers head is provided with a holding cavity, and the two tweezers handles can be respectively clamped into the holding cavities of the two tweezers heads. The forceps handle of the forceps can be clamped into the accommodating cavity of the forceps head, the forceps head can be conveniently replaced, the elastic sheet arranged on the forceps handle body and used for clamping the forceps head is easy to damage after being used for multiple times, and once the elastic sheet is damaged, the whole forceps can be scrapped, so that materials are wasted.
A novel medical anti-bacterial forceps with easily replaceable head and long service life is urgently needed in the industry.
Disclosure of Invention
The invention aims to provide medical antibacterial tweezers with an easily-replaceable head, and aims to solve the technical problems that the whole tweezers are scrapped once the most easily-worn tweezers head is damaged, materials are wasted, and the antibacterial performance of the tweezers is poor.
In order to achieve the purpose, the invention provides medical antibacterial tweezers with easily replaceable heads, which are easy to replace heads, can emit light and resist bacteria and have longer service life, and adopts the following technical scheme: the utility model provides a medical antibiotic tweezers of easily trading head, includes two elasticity tweezers handles and two tweezers heads, and this two elasticity tweezers handles one end is fixed together, and the other end forms the free end each other at an interval, be provided with the holding chamber respectively on two elasticity tweezers handle free end corresponding position and be equipped with the draw-in groove that leads to the holding chamber respectively in the symmetry both sides face, two elasticity tweezers handle surface respectively coats and has the luminous dope layer, luminous dope is selected from one of fluorescent paint or phosphorescence dope, two tweezers heads all include tweezers head front portion and tweezers head rear portion, tweezers head rear portion fixed mounting has two elastic arms, two elastic arms install symmetrically in tweezers head rear portion's both sides, two elastic arm width are the same with tweezers head rear portion cross-section width, two elastic arm free ends be equipped with respectively with the corresponding arch of draw-in groove. The forceps head is detachably arranged on the forceps handle.
The two elastic forceps handles are made of the following raw materials in parts by weight: 80-90 parts of polypropylene, 10-15 parts of antibacterial filler and 1-2 parts of antioxidant;
the antibacterial filler is prepared by the following steps:
1) and (3) synthesis of polypyrrole nanotubes: FeCl is added3·6H2Dispersing O and methyl orange in water, adding pyrrole monomer when flocculent substances are generated, and stirring at room temperature for 24-30 hours. Obtaining black suspension, filtering and drying to obtain black solid matter;
2) dihalide-modified polypyrrole nanotubes: ultrasonically dispersing the polypyrrole nanotube prepared in the step 1) in DMF (dimethyl formamide), then dropwise adding a dihalide, and stirring and reacting for 4-8 hours at 40-60 ℃. Performing suction filtration separation to obtain black solid, sequentially washing with ethyl acetate and diethyl ether for 3-5 times, and vacuum drying at 40-50 deg.C for 12-24 hr to obtain product;
3) dopamine grafted dihalide modified polypyrrole nanotubes: dispersing the polypyrrole nanotubes modified by the dihalide prepared in the step 2) in 1-2mol/L dopamine aqueous solution at 40-50 ℃ for 60-72 hours, then soaking in water for 30-48 hours, filtering, and vacuum drying at 40-50 ℃ for 12-24 hours to obtain a product;
4) preparing the antibacterial filler: dispersing the dopamine-grafted dihalide-modified polypyrrole nanotube prepared in the step 2) in 1-2mol/L sodium alginate aqueous solution at 40-50 ℃ for 60-72 hours, then soaking in water for 30-48 hours, filtering, and vacuum-drying at 40-50 ℃ for 12-24 hours to obtain a product;
further, the FeCl in the step 1)3·6H2The mass ratio of O, methyl orange, water and pyrrole monomer is as follows: 50: 2: (250-500): (2-4);
further, the mass ratio of the polypyrrole nanotubes, DMF and dihalides in the step 2) is as follows: 1: (5-8): (5-10);
the dihalide is selected from one or more of 1, 2-dichloropropane, 1, 4-dichlorobutane, 1, 5-dichloropentane, 1, 5-dibromopentane, 1, 4-dibromobutane and 1, 2-dichlorobromopropane;
the antioxidant is selected from one or more of antioxidant 1010, antioxidant 168, antioxidant 1024 and antioxidant 1076;
due to the application of the technical scheme, compared with the prior art, the invention has the following advantages: the medical antibacterial forceps with the easily replaceable head disclosed by the invention adopts a split type clamping mode of the elastic forceps handle and the forceps head, when the forceps are not used due to the fact that the forceps head is broken, becomes blunt and the like, the forceps head can be taken out, and a new forceps head is replaced, so that the characteristic that a handle is not easy to damage can be fully utilized, the service life of the forceps is prolonged to the maximum extent, materials can be saved, the use cost is reduced, and the problems that the forceps need to be fixed by screws usually, are more complicated and are inconvenient to replace are avoided; in addition, the tweezers elastic tweezers handle is made of an antibacterial material, so that the tweezers elastic tweezers handle has an antibacterial effect, the polypyrrole tube has a large surface area, the antibacterial property is favorably ensured, and the antistatic property is also ensured, in addition, groups such as dopamine and alginic acid are grafted on the synthetic material, so that the tweezers have good biocompatibility, the luminous coating layer is coated on the outer surface of the tweezers elastic tweezers handle, the luminous tweezers handle can emit light and is easy to find in a dark place, the luminous tweezers handle is also suitable for playing a light supplementing role when the tweezers are used in the dark place, and shadows can not be generated.
Drawings
Fig. 1 is a three-dimensional exploded view of the medical antibacterial easy-to-replace head forceps of the invention.
The reference numbers illustrate: 1-an elastic forceps handle; 2-a card slot; 3-an accommodating cavity; 4-bulge; 5-a resilient arm; 6-forceps head.
Detailed Description
In order to make the technical solutions of the present invention better understood by those skilled in the art, the following detailed description of the present invention is provided with reference to the accompanying drawings.
Other materials used in the following examples of the present invention were from Shanghai spring Xin import & export trade company, Inc.
Example 1
Referring to fig. 1, a medical antibiotic easily trades first tweezers, includes two elasticity tweezers handles 1 and two tweezers heads 6, and the one end of these two elasticity tweezers handles 1 is fixed together, and the other end separates each other and forms free end, its characterized in that: the corresponding positions of the free ends of the two elastic forceps handles 1 are respectively provided with an accommodating cavity 3 and clamping grooves 2 communicated with the accommodating cavity 3 and arranged on two symmetrical side surfaces, the outer surfaces of the two elastic forceps handles 1 are respectively coated with a luminous coating, the luminous coating is selected from one of fluorescent coatings or phosphorescent coatings, the two forceps heads 6 respectively comprise a forceps head front part and a forceps head rear part, the forceps head rear part is fixedly provided with two elastic arms 5, the two elastic arms 5 are symmetrically arranged on two sides of the rear part of the forceps head 6, the width of the two elastic arms 5 is the same as the width of the section of the rear part of the forceps head 6, and the free ends of the two elastic arms 5 are respectively provided with protrusions 4 corresponding to the clamping grooves 2.
During assembly, the two elastic arms 5 fixedly installed at the rear parts of the forceps heads 6 respectively extend into the accommodating cavities 3 of the two elastic forceps handles 1, so that the protrusions 4 which are respectively arranged at the free ends of the two elastic arms 5 and correspond to the clamping grooves 2 are clamped and blocked in the corresponding clamping grooves 2, and the two forceps heads 6 are fastened on the corresponding forceps handles 1.
When the forceps head 6 needs to be replaced, the protrusions 4 corresponding to the clamping grooves 2 and arranged at the free ends of the two corresponding elastic arms 5 are pressed downwards, so that the protrusions 4 exit from the clamping grooves 2 and enter the accommodating cavity 3, and the forceps head 6 can be detached.
The two elastic forceps handles are made of the following raw materials in parts by weight: 85 parts of polypropylene, 13 parts of antibacterial filler and 10102 parts of antioxidant;
the antibacterial filler is prepared by the following steps:
1) and (3) synthesis of polypyrrole nanotubes: FeCl is added3·6H2When 2500g of water was used to disperse 500g of O and 20g of methyl orange, and when flocculent substances were formed, 20g of pyrrole monomer was added and the mixture was stirred at room temperature for 24 hours. Obtaining black suspension, filtering and drying to obtain black solid matter;
2) dihalide-modified polypyrrole nanotubes: 20g of polypyrrole nanotubes prepared in step 1) were dispersed in DMF100g by ultrasonic dispersion, and then 100g of 1.2-dichloropropane was added dropwise thereto, and the reaction was stirred at 40 ℃ for 4 hours. Performing suction filtration separation to obtain a black solid, sequentially washing with ethyl acetate and diethyl ether for 5 times respectively, and then performing vacuum drying at 40 ℃ for 12 hours to obtain a product;
3) dopamine grafted dihalide modified polypyrrole nanotubes: dispersing the polypyrrole nanotubes modified by the dihalide prepared in the step 2) in 1mol/L aqueous solution of dopamine at 40 ℃ for 60 hours, then soaking in water for 30 hours, filtering, and vacuum-drying at 40 ℃ for 12 hours to obtain a product;
4) preparing the antibacterial filler: dispersing the dopamine grafted dihalide modified polypyrrole nanotube prepared in the step 2) in 1mol/L sodium alginate aqueous solution at 40 ℃ for 60 hours, then soaking in water for 30 hours, filtering, and vacuum drying at 40 ℃ for 12 hours to obtain a product.
Example 2
Referring to fig. 1, a medical antibiotic easily trades first tweezers, includes two elasticity tweezers handles 1 and two tweezers heads 6, and the one end of these two elasticity tweezers handles 1 is fixed together, and the other end separates each other and forms free end, its characterized in that: the corresponding positions of the free ends of the two elastic forceps handles 1 are respectively provided with an accommodating cavity 3 and clamping grooves 2 communicated with the accommodating cavity 3 and arranged on two symmetrical side surfaces, the outer surfaces of the two elastic forceps handles 1 are respectively coated with a luminous coating, the luminous coating is selected from one of fluorescent coatings or phosphorescent coatings, the two forceps heads 6 respectively comprise a forceps head front part and a forceps head rear part, the forceps head rear part is fixedly provided with two elastic arms 5, the two elastic arms 5 are symmetrically arranged on two sides of the rear part of the forceps head 6, the width of the two elastic arms 5 is the same as the width of the section of the rear part of the forceps head 6, and the free ends of the two elastic arms 5 are respectively provided with protrusions 4 corresponding to the clamping grooves 2.
During assembly, the two elastic arms 5 fixedly installed at the rear parts of the forceps heads 6 respectively extend into the accommodating cavities 3 of the two elastic forceps handles 1, so that the protrusions 4 which are respectively arranged at the free ends of the two elastic arms 5 and correspond to the clamping grooves 2 are clamped and blocked in the corresponding clamping grooves 2, and the two forceps heads 6 are fastened on the corresponding forceps handles 1.
When the forceps head 6 needs to be replaced, the protrusions 4 corresponding to the clamping grooves 2 and arranged at the free ends of the two corresponding elastic arms 5 are pressed downwards, so that the protrusions 4 exit from the clamping grooves 2 and enter the accommodating cavity 3, and the forceps head 6 can be detached.
The two elastic forceps handles are made of the following raw materials in parts by weight: 88 parts of polypropylene, 11 parts of antibacterial filler and 1681 part of antioxidant;
the antibacterial filler is prepared by the following steps:
1) and (3) synthesis of polypyrrole nanotubes: 500g of FeCl3·6H2When 3000g of water was dispersed in 20g of O and methyl orange and flocculent substances were generated, 20g of pyrrole monomer was added and the mixture was stirred at room temperature for 27 hours. Obtaining black suspension, filtering and drying to obtain black solid matter;
2) dihalide-modified polypyrrole nanotubes: 20g of polypyrrole nanotubes prepared in step 1) were dispersed in DMF120g by sonication, and then 130g of 1, 4-dichlorobutane was added dropwise thereto, and the reaction was stirred at 50 ℃ for 6 hours. Performing suction filtration separation to obtain a black solid, sequentially washing with ethyl acetate and diethyl ether for 4 times respectively, and then performing vacuum drying at 46 ℃ for 20 hours to obtain a product;
3) dopamine grafted dihalide modified polypyrrole nanotubes: dispersing the polypyrrole nanotubes modified by the dihalide prepared in the step 2) in 1.5mol/L aqueous solution of dopamine at 45 ℃ for 66 hours, then soaking in water for 40 hours, filtering, and vacuum-drying at 46 ℃ for 16 hours to obtain a product;
4) preparing the antibacterial filler: dispersing the dopamine grafted dihalide modified polypyrrole nanotube prepared in the step 2) in 1.5mol/L sodium alginate aqueous solution at 49 ℃ for 70 hours, then soaking in water for 42 hours, filtering, and vacuum drying at 46 ℃ for 19 hours to obtain a product.
Example 3
Referring to fig. 1, a medical antibiotic easily trades first tweezers, includes two elasticity tweezers handles 1 and two tweezers heads 6, and the one end of these two elasticity tweezers handles 1 is fixed together, and the other end separates each other and forms free end, its characterized in that: the corresponding positions of the free ends of the two elastic forceps handles 1 are respectively provided with an accommodating cavity 3 and clamping grooves 2 communicated with the accommodating cavity 3 and arranged on two symmetrical side surfaces, the outer surfaces of the two elastic forceps handles 1 are respectively coated with a luminous coating, the luminous coating is selected from one of fluorescent coatings or phosphorescent coatings, the two forceps heads 6 respectively comprise a forceps head front part and a forceps head rear part, the forceps head rear part is fixedly provided with two elastic arms 5, the two elastic arms 5 are symmetrically arranged on two sides of the rear part of the forceps head 6, the width of the two elastic arms 5 is the same as the width of the section of the rear part of the forceps head 6, and the free ends of the two elastic arms 5 are respectively provided with protrusions 4 corresponding to the clamping grooves 2.
During assembly, the two elastic arms 5 fixedly installed at the rear parts of the forceps heads 6 respectively extend into the accommodating cavities 3 of the two elastic forceps handles 1, so that the protrusions 4 which are respectively arranged at the free ends of the two elastic arms 5 and correspond to the clamping grooves 2 are clamped and blocked in the corresponding clamping grooves 2, and the two forceps heads 6 are fastened on the corresponding forceps handles 1.
When the forceps head 6 needs to be replaced, the protrusions 4 corresponding to the clamping grooves 2 and arranged at the free ends of the two corresponding elastic arms 5 are pressed downwards, so that the protrusions 4 exit from the clamping grooves 2 and enter the accommodating cavity 3, and the forceps head 6 can be detached.
The two elastic forceps handles are made of the following raw materials in parts by weight: 80-90 parts of polypropylene, 10-15 parts of antibacterial filler and 10241-2 parts of antioxidant;
the antibacterial filler is prepared by the following steps:
1) and (3) synthesis of polypyrrole nanotubes: 500g of FeCl3·6H2O and 20g of methyl orange were dispersed in 5000g of water, and when flocculent substances were generated, 20g of pyrrole monomer was added and stirred at room temperature for 30 hours. Obtaining black suspension, filtering and drying to obtain black solid matter;
2) dihalide-modified polypyrrole nanotubes: 20g of polypyrrole nanotubes prepared in step 1) were dispersed in DMF160g by ultrasonic dispersion, and 200g of 1, 4-dibromobutane was added dropwise thereto, and the reaction was stirred at 60 ℃ for 8 hours. Performing suction filtration separation to obtain a black solid, sequentially washing with ethyl acetate and diethyl ether for 5 times respectively, and then performing vacuum drying at 50 ℃ for 24 hours to obtain a product;
3) dopamine grafted dihalide modified polypyrrole nanotubes: dispersing the polypyrrole nanotubes modified by the dihalide prepared in the step 2) in 2mol/L aqueous solution of dopamine at 50 ℃ for 72 hours, then soaking in water for 48 hours, filtering, and vacuum-drying at 50 ℃ for 24 hours to obtain a product;
4) preparing the antibacterial filler: dispersing the dopamine-grafted dihalide-modified polypyrrole nanotube prepared in the step 2) in a 2mol/L sodium alginate aqueous solution at 50 ℃ for 72 hours, then soaking in water for 48 hours, filtering, and vacuum-drying at 50 ℃ for 24 hours to obtain a product;
further, the mass ratio of the polypyrrole nanotubes, DMF and dihalides in the step 2) is as follows: 1: (5-8): (5-10);
the dihalide is selected from one or more of 1, 2-dichloropropane, 1, 4-dichlorobutane, 1, 5-dichloropentane, 1, 5-dibromopentane, 1, 4-dibromobutane and 1, 2-dichlorobromopropane;
the antioxidant is selected from one or more of antioxidant 1010, antioxidant 168, antioxidant 1024 and antioxidant 1076.
Test example 1
The materials obtained in examples 1 to 3 were subjected to an antibacterial test: all samples were autoclaved at 121 ℃ for 40min, and a bacterial solution at a concentration of 107CFU/mL was dropped onto the surface of the sterilized samples (0.06 mL/cm)2) Then, the sample with the bacterial liquid is put into a constant temperature incubator at 37 ℃ for 24 hours. Samples cultured for 24 hours are taken out, and bacterial liquid is diluted by multiple times and inoculated on agar plates containing culture medium. Placing the inoculated agar plate into a constant-temperature incubator at 37 ℃ for 24h, and taking out the agar plate after 24h of culture to calculate the number of viable bacteria (refer to the national standard GB/T4789.2); dividing the number of the live bacteria by the total bacteria to obtain the antibacterial rate; the results are shown in Table 1.
The result shows that the material of the invention has obvious antibacterial capacity to escherichia coli, and the antibacterial rate is higher than 99.5%; has obvious antibacterial capacity to staphylococcus aureus, and the antibacterial rate is higher than 99.8 percent.
TABLE 1 antibacterial Properties of the materials
| Antibacterial ratio of Escherichia coli (%) | Staphylococcus aureus antibacterial ratio (%) | |
| Example 1 | 99.7 | 99.9 |
| Example 2 | 99.5 | 100 |
| Example 3 | 99.8 | 99.8 |
The foregoing is merely a preferred embodiment of the invention and is not intended to limit the invention in any manner; the present invention may be readily implemented by those of ordinary skill in the art as illustrated in the accompanying drawings and described above; however, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention; meanwhile, any changes, modifications, and evolutions of the equivalent changes of the above embodiments according to the actual techniques of the present invention are still within the protection scope of the technical solution of the present invention.
Claims (4)
1. The medical antibacterial tweezers with the easily replaceable heads is characterized by comprising two elastic tweezers handles, two tweezers heads and a luminous coating layer coated on the outer surfaces of the two elastic tweezers handles, wherein one ends of the two elastic tweezers handles are fixed together, the other ends of the two elastic tweezers handles are mutually spaced to form free ends, the corresponding positions of the free ends of the two elastic tweezers handles are respectively provided with an accommodating cavity and clamping grooves communicated with the accommodating cavity and formed in two symmetrical side surfaces respectively, the two tweezers heads respectively comprise a front part of the tweezers head and a rear part of the tweezers head, the rear part of the tweezers head is fixedly provided with two elastic arms, the two elastic arms are symmetrically arranged on two sides of the rear part of the tweezers head, the widths of the two elastic arms are the same as the width of the section of the rear part of the tweezers head, and the free ends of the two elastic arms are respectively provided; the two elastic forceps handles are made of the following raw materials in parts by weight: 80-90 parts of polypropylene, 10-15 parts of antibacterial filler and 1-2 parts of antioxidant;
the antibacterial filler is prepared by the following steps:
1) and (3) synthesis of polypyrrole nanotubes: FeCl is added3·6H2Dispersing O and methyl orange in water, adding pyrrole monomer when flocculent substances are generated, and stirring for 24-30 hours at room temperature; obtaining black suspension, filtering and drying to obtain black solid matter;
2) dihalide-modified polypyrrole nanotubes: ultrasonically dispersing the polypyrrole nanotube prepared in the step 1) in DMF, then dropwise adding a dihalide, and stirring and reacting for 4-8 hours at 40-60 ℃; performing suction filtration separation to obtain black solid, sequentially washing with ethyl acetate and diethyl ether for 3-5 times, and vacuum drying at 40-50 deg.C for 12-24 hr to obtain product;
3) dopamine grafted dihalide modified polypyrrole nanotubes: dispersing the polypyrrole nanotubes modified by the dihalide prepared in the step 2) in 1-2mol/L dopamine aqueous solution at 40-50 ℃ for 60-72 hours, then soaking in water for 30-48 hours, filtering, and vacuum drying at 40-50 ℃ for 12-24 hours to obtain a product;
4) preparing the antibacterial filler: dispersing the dopamine-grafted dihalide-modified polypyrrole nanotube prepared in the step 3) in 1-2mol/L sodium alginate aqueous solution at 40-50 ℃ for 60-72 hours, then soaking in water for 30-48 hours, filtering, and vacuum-drying at 40-50 ℃ for 12-24 hours to obtain a product;
the FeCl in the step 1)3·6H2The mass ratio of O, methyl orange, water and pyrrole monomer is 50: 2: (250-500): (2-4);
the mass ratio of the polypyrrole nanotubes to the DMF to the dihalides in the step 2) is 1: (5-8): (5-10).
2. The medical antibacterial easy-to-change-head forceps according to claim 1, wherein the dihalide is one or more selected from the group consisting of 1, 2-dichloropropane, 1, 4-dichlorobutane, 1, 5-dichloropentane, 1, 5-dibromopentane and 1, 4-dibromobutane.
3. The medical antibacterial easy-to-change-head forceps according to claim 1, wherein the antioxidant is one or more selected from the group consisting of antioxidant 1010, antioxidant 168, antioxidant 1024, and antioxidant 1076.
4. The medical antibacterial easy-to-change-head forceps according to claim 1, wherein the luminous paint is selected from one of fluorescent paint and phosphorescent paint.
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| CN201710634976.8A CN107186637B (en) | 2017-07-30 | 2017-07-30 | Medical antibacterial tweezers with easily-replaceable heads |
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|---|---|---|---|---|
| US5334215A (en) * | 1993-09-13 | 1994-08-02 | Chen Shih Chieh | Pincers having disposable end members |
| CN102476359A (en) * | 2010-11-24 | 2012-05-30 | 鸿富锦精密工业（深圳）有限公司 | Tweezers |
| CN204709054U (en) * | 2015-04-21 | 2015-10-21 | 北京青藤谷禧干细胞科技研究院有限公司 | A kind of tweezers for the treatment of biological tissue |
| CN105327626A (en) * | 2015-11-19 | 2016-02-17 | 福州顺升科技有限公司 | Composite nanofiltration membrane and preparation method thereof |
| CN106581734A (en) * | 2016-11-22 | 2017-04-26 | 孙祎 | Preparation method of highly antibacterial alginate dressing |
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2017
- 2017-07-30 CN CN201710634976.8A patent/CN107186637B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5334215A (en) * | 1993-09-13 | 1994-08-02 | Chen Shih Chieh | Pincers having disposable end members |
| CN102476359A (en) * | 2010-11-24 | 2012-05-30 | 鸿富锦精密工业（深圳）有限公司 | Tweezers |
| CN204709054U (en) * | 2015-04-21 | 2015-10-21 | 北京青藤谷禧干细胞科技研究院有限公司 | A kind of tweezers for the treatment of biological tissue |
| CN105327626A (en) * | 2015-11-19 | 2016-02-17 | 福州顺升科技有限公司 | Composite nanofiltration membrane and preparation method thereof |
| CN106581734A (en) * | 2016-11-22 | 2017-04-26 | 孙祎 | Preparation method of highly antibacterial alginate dressing |
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