CN107184467A - A kind of hair care exterior-applied article being made of Lignum Xanthoceratis extract and preparation method thereof - Google Patents
A kind of hair care exterior-applied article being made of Lignum Xanthoceratis extract and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/704—Polygonum, e.g. knotweed
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- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention provides a kind of hair care exterior-applied article being made of Lignum Xanthoceratis extract and preparation method thereof.A kind of extract obtained after the hair care exterior-applied article being made of Lignum Xanthoceratis extract, including following components extraction：Shinyleaf yellowhorn shell/carpopodium, gleditsia sinensis, the fleece-flower root, Eclipta prostrata and kuh-seng, and the weight ratio of above component is：50~65:10~20:5~10:5~10:5~10.In the composition that the present invention is provided, the emphasis of five components is different, but pass through five coordinated, start with from multiple dimensions, elimination causes the unfavorable factors such as abnormal bacteria breed, fat secretion, hypoimmunity, the nutritional deficiency of fur systemic metabolism comprehensively, while improving body self-repairing capability by antioxidation, makes one the metabolism of chaeta dermal system and is in poised state, and nutrition persistently, expeditiously for hair growth is provided, so as to be finally reached anti-dandruff, antipruritic and black hair effect.
Description
Technical field
The present invention relates to washing product field, more particularly, to a kind of hair care exterior-applied article being made of Lignum Xanthoceratis extract and
Its preparation method.
Background technology
Shiny-leaved yellowhorn (scientific name：Xanthoceras sorbifolium Bunge), Sapindaceae, shiny-leaved yellowhorn belong to machaka
Or dungarunga, it is high up to 5 meters；Sprig maroon is sturdy, and leaf connecting handle length is up to 30 centimetres；Leaflet is to life, and both sides are slightly asymmetric, top
End is tapering, and there is sharp keen sawtooth at base portion wedge shape, edge, and the inflorescence basidixed of hermaphrodite flower, male inflorescence axillary, uprightly, total bennet are short, petal
White, base portion aubergine or yellow, the horn shape appendage of floral disc are orange-yellow, and filigree is hairless；Capsule is up to 6 centimetres；Seed black
And it is glossy.Shiny-leaved yellowhorn spring blooms, autumn firstfruits.
Shiny-leaved yellowhorn be the distinctive rare woody oily section crop of China, be greening, it is edible, medicinal and making bio-fuel weight
Woody oil tree species are wanted, are paid close attention to extensively by academia in recent years.The medicinal parts such as its kernel, shell, carpopodium, branches and leaves are rich in three
Content is higher in the active ingredients such as terpene saponin(e, sterol, flavones, cumarin, tartaric acid, especially carpopodium and shell.
Triterpene saponins belong to nonionic surfactant, and pH value is between 6.0~7.0, with very low critical micell
Concentration (CMC) and surface tension (γ CMC), can with the multiple biological activities such as good antibacterial, anti-inflammatory, anti-oxidant, antimycotic
Be widely used in daily use chemicals industry, Triterpene saponins can as natural detergent, with preferable clean result, and not phosphorous, aluminium,
The materials such as benzene, body of not hurting sb.'s feelings, not polluted source, environmental protection is environment-friendly, is that a kind of more satisfactory hand cleanser, hair washing are fragrant
The raw materials such as ripple, shower cream, cosmetics, with larger research and development Exploitative potential.Triterpenes total saponins are to wine brewing sugar
There is stronger antibacterial activity to act on for saccharomycete and candida utili, also relatively strong to saccharomycete inhibitory action, therefore can
To help improve the skin problem such as skin whelk, blackspot, wrinkle, dry skin, coarse.
Sterol, flavones, cumarin, tartaric acid can help skin removed to be deposited in the aging cutin of outer layer.Therefore to shiny-leaved yellowhorn
Deep processing is carried out, the active ingredients such as Triterpene saponins, sterol, flavones, cumarin, tartaric acid are therefrom extracted, with great work
Industry meaning.
To sum up, Lignum Xanthoceratis extract has many physiologically actives, but relatively low to the Exploitation degree of shiny-leaved yellowhorn at present, especially sharp
The shield product of washing developed with it is rarely reported.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of hair care exterior-applied article being made of Lignum Xanthoceratis extract, the hair care external application
Five compositions synergy of product, with anti-dandruff, antipruritic and black hair effect, can be made into the hair care articles of diversified forms.
The second object of the present invention is the preparation method for providing above-mentioned hair care exterior-applied article, and flow is simple, can effectively protect
The activity of effective component.
In order to realize the above object the invention provides following technical scheme：
A kind of extract obtained after the hair care exterior-applied article being made of Lignum Xanthoceratis extract, including following components extraction：Text
Shell/carpopodium, gleditsia sinensis, the fleece-flower root, Eclipta prostrata and kuh-seng are preced with, and the weight ratio of above component is：50~65:10~20:5~
10:5~10:5~10.
Gleditsia sinensis is rich in gleditschiasaponin B-G (gleditsiasaaponin B-G), palmitic acid (palmitic acid), hard ester
Acid, oleic acid, sub- sterol, sitosterol, nonacosane (nonacosane) etc..Gleditschiasaponin is a kind of natural table of pentacyclic triterpene
Face activating agent, foaming abundancy, easily biological-degradable is nontoxic to human body, with preferable surface-active and washability；And
With antiphlogistic antibacterial, the effect for the desinsection that dehumidifies.Gleditschiasaponin for Escherichia coli, staphylococcus aureus, saccharomyces cerevisiae all
Certain inhibitory action can be played.
Polygonum multiforum root tuber is used as medicine, and can be calmed the nerves, blood-nourishing, active, is detoxified, disappear carbuncle；RADIX POLYGONI MULTIFLORI PREPARATA can help essence and blood, black beard and hair, strong
Muscles and bones, filling liver kidney, are your common detail medicinal materials.Stibene-glucoside is the important activity composition in the fleece-flower root, is disappeared with anti-oxidant
Except free radical, cholesterol is reduced, liver protection mitigates the multi-efficiencies such as brain damage caused by cerebral ischemia.
Eclipta prostrata is containing in saponin(e, tannin, vitamin A sample material, ecliptine, three thianthrene methanol, three thianthrene formaldehyde, alligator weed
Ester, remove first alligator weed lactone, remove the compositions such as first alligator weed lactone glycoside and nicotine.With raising body non-specific immune function,
Eliminate oxygen radical to suppress 5- lipoxygenase, protect chromosome, liver protection promotes the regeneration of liver cell, increases coronary flow,
Extend life of the mouse under normobaric hypoxia, improve the survival rate of the mouse in the case of hypobaric hypoxia, and have calm, analgesia, promote
Enter hair growth, act on hair blackening, hemostasis, antibacterial, anti-Amoeba, anticancer etc..Eclipta prostrata, which has, to be significantly immunized
Adjustment effect, non-irrigated lotus glycosides A and B especially contained by it.
Kuh-seng is cold in nature, has heat-clearing and damp-drying drug, effect of desinsection, kuh-seng bath can remove damp-heat in lower-JIAO, and desinsection is antipruritic, right
Pruitus has good mitigation, can Bergamot Mint Extract, dredge and restrain pore, remove skin endotoxin contamination,
Its abundant herbal nutrition promotes the growth and reparation of damaged blood vessels nerve cell, recovers subcutaneous capillary cell viability, flesh
Skin, which reappears, to compact fine and smooth, plays a part of beauty and skin care.Banlangen and oxymatrine in kuh-seng have obvious rise to make in vain
With having obvious therapeutic action to Neuroleptic Leukocytopenia caused by endoxan, X-ray and cobalt radiation exposure.Kuh-seng also has anti-
Inflammation effect, matrine oozes out increase, Rat Carrageenan to mouse peritoneal caused by auricle edema caused by mouse knoting oil, acetic acid
Colloidality footpad swelling, there is inhibitory action.
In the present invention, the shell and carpopodium of shiny-leaved yellowhorn are all rich in Triterpene saponins, and it has emulsification cleaning effect and stronger
Antibacterial activity；The shell and carpopodium of shiny-leaved yellowhorn are also rich in sterol, flavones, and it has the effect for removing aging cutin layer, Wen Guan
The shell and carpopodium of fruit also contain specific protein and amino acid, and these materials can adjust scalp fat secretion system；Soap
Gleditschiasaponin in angle has stronger washability and antiphlogistic antibacterial, dehumidifying insecticidal effect；The fleece-flower root has antioxidant effect,
Also there is liver protection and improve the effect of brain blood system circulation, hair synthesis of melanin can be promoted；Eclipta prostrata supplements human body
Required vitamin and trace element, while improving immunity of organisms, delay body aging, and it cooperates with promotion hair with the fleece-flower root
Growth and the generation of melanin；And kuh-seng removes damp-heat in lower-JIAO, Bergamot Mint Extract strengthens subcutaneous capillary cell viability.By
This is visible, in the composition that provides of the present invention, and the emphasis of five components is different, but by five coordinated, from multiple
Dimension is started with, and the bacteria breed for causing fur systemic metabolism abnormal, fat secretion, hypoimmunity, nutritional deficiency are eliminated comprehensively
Etc. unfavorable factor, while improving body self-repairing capability by antioxidation, the metabolism of chaeta dermal system is made one in balance
State, and nutrition persistently, expeditiously for hair growth is provided, so as to be finally reached anti-dandruff, antipruritic and black hair effect.
Formula can also further optimize above, to obtain more preferable therapeutic effect, and for example formula is：
Shinyleaf yellowhorn shell/carpopodium, gleditsia sinensis, the fleece-flower root, the weight ratio of Eclipta prostrata and kuh-seng are：55~60:15~20:5~10:
5~10:5~10.
Product described above mainly reaches anti-dandruff, antipruritic and black hair effect by external application, for exterior-applied formulation, combination
The existence form or quality of thing are had a major impact to the drug effect of product, in order to improve drug effect, and preferred pair composition is extracted,
It is preferred that extracting method be：
Using 10%~30% methanol or 10%~30% ethanol as solvent, solid-liquid ratio is 1:8~1:15, pH value of solution be 4~
6, cellulase of the weight for 1~3wt% of reaction solution is added, 30 DEG C~50 DEG C are heated up to, first time solvent extraction is carried out,
Filtering, collects filter residue and filtrate；
10%~30% methanol or 10%~30% ethanol are added into the filter residue, solid-liquid ratio is 1:8~1:15, solution
PH is 9~11, adds alkali protease of the weight for 1~3wt% of reaction solution, is heated up to 30 DEG C~50 DEG C, carries out second
Secondary solvent extraction, filtering is collected filtrate and merged with the filtrate that the first time solvent extraction is obtained.
First, using above solvent extraction, more preferably, contained active component enriches the quality of obtained extract, both wraps
Containing water-soluble material, also comprising alcohol-soluble material, the collaboration of two constituents can more improve anti-dandruff, antipruritic, black hair effect.
Secondly, above-mentioned technique is extracted in two steps, and the reaction condition often walked is different with the enzyme added, its main purpose
To promote different kinds of proteins and amino acid in shiny-leaved yellowhorn to be discharged from cell, and dissolve in a solvent, so as to in gleditsia sinensis
Sub- sterol, the Stibene-glucoside in the fleece-flower root, the saponin(e in Eclipta prostrata, the Banlangen synergy in kuh-seng, enhancing goes
Bits and black hair effect.
It can also be stirred in extraction process, accelerate the flowing of material, mixing speed is preferably 20~100 revs/min.
Preferably, also include after second of solvent extraction：Filtrate after the merging is adjusted into pH to neutral, de-
Color, concentration, drying.
Decolourize further removal of impurities, it is convenient after concentrate drying to preserve, and applicable formulation is more rich.
Preferably, the method for the decolouring is：The activity of 0.1~0.5 times of its weight is added into solution to be decolourized
Charcoal, completes to filter after absorption.Wherein, filtering is filtered preferably in centrifuge, and rotating speed is preferably 3000 revs/min.
Preferably, the method for the concentration is：In vacuum -0.01~-0.092MPa, 0.1~0.5MPa of steam pressure
Under water content 40wt%~50wt% concentrate is made；
The method of the drying is：It is spray-dried at 150 DEG C~220 DEG C of EAT.
Concentration and the cooperation of dry two step processes are extremely important, and higher efficiency ratio can not only be obtained using process above,
And the quality of products obtained therefrom is preferable.
The product form that the present invention is applicable has shampoo, shampoo or hair conditioner etc..Wherein, the application of shampoo
It is relatively wide, to prepare shampoo finished product, also need to add ethoxylated dodecyl alcohol sodium sulphate, guar gum and sodium chloride.
Ethoxylated dodecyl alcohol sodium sulphate is as fizzy emulsifying agent, and guar gum can be with antistatic and thickening, chlorine
Changing sodium is used to adjust ion concentration.
Above product as efficacy shampoo, with wider application prospect.
Unsuitable too high or too low, the preferably 15~20wt% of accounting of consumption of the extract in shampoo.
The weight ratio of wherein ethoxylated dodecyl alcohol sodium sulphate, guar gum and sodium chloride is preferably 5~7:0.1~0.2:
1~2.The product of the proportioning is small to the excitant of scalp.
The preparation method of shampoo is：It is addition ethoxylated dodecyl alcohol sulfuric acid in 40 DEG C~60 DEG C of water to temperature
Sodium, guar gum, sodium chloride, the extract and remaining raw material, mixing are produced.
In above-mentioned mixed process, feed while stirring, mixing speed is advisable with 100 revs/min, due to laruyl alcohol polyoxy
Ethene ether sodium sulfate and guar gum are not readily dissolved, therefore preferably first add both dissolvings, and remaining raw material is added afterwards.
To sum up, compared with prior art, invention achieves following technique effect：
(1) using the synergy between shinyleaf yellowhorn fruit shell/carpopodium, gleditsia sinensis, the fleece-flower root, Eclipta prostrata and kuh-seng, obtain
Significant anti-dandruff, antipruritic and black hair effect；
(2) quality of extract is improved by improving the extraction process of composition, so as to further increase hair care effect
Really；
(3) provide a kind of use be more convenient, make simpler shampoo, be the extensive use of the composition of the present invention
Prerequisite is provided.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, but ability
Field technique personnel will be understood that following described embodiment is a part of embodiment of the invention, rather than whole embodiments,
The present invention is merely to illustrate, and is not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument
Unreceipted production firm person, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
A kind of powdered extract
1st, according to parts by weight：Shinyleaf yellowhorn shell or carpopodium 50% are added, gleditsia sinensis 20%, the fleece-flower root 10%, Eclipta prostrata 10% is bitter
Ginseng 10%, is well mixed, and is ground into≤5mm particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:It is molten for 30% methanol that 15 ratio adds content
Agent；With salt acid for adjusting pH to 4, cellulase is added according to the ratio of feed liquid parts by weight 3%, 50 DEG C are heated up to, turned in mixer
Under the conditions of 20 revs/min of speed, extraction time 30 minutes；It is warming up to 90 DEG C to be kept for 30 minutes, methanol at reflux solvent, and realizes enzyme system
The deactivation of agent.Cool under normal temperature condition, adjust pH value to 7 with sodium hydroxide, release filtrate standby.
3rd, the filter residue for extracting first time after filtrate is stored in extractor, is carried out second and is extracted, according to solid-liquid ratio 1:
15 ratio adds the methanol solvate that content is 30%；PH to 11 is adjusted with sodium hydroxide, according to the ratio of feed liquid parts by weight 3%
Alkali protease, is heated up to 50 DEG C, under the conditions of 20 revs/min of mixer rotating speed, extraction time 30 minutes；It is warming up to 90 DEG C of guarantors
Hold 30 minutes, methanol at reflux solvent, and realize the deactivation of enzyme preparation, cool under normal temperature condition, use salt acid for adjusting pH value
To 7, filtrate is released standby.
4th, extract solution twice is merged, according to 10:5 ratio adds 4A types zeolite and carries out decolorization, 3000 turns of rotating speed/
Separation of solid and liquid is carried out in the centrifuge of minute, filtered fluid is reclaimed.
5th, concentrate is made in vacuum -0.092MPa, steam pressure 0.1MPa in filtered fluid.
6th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 220 DEG C of EAT.
Embodiment 2
A kind of powdered extract
1st, according to parts by weight：Shinyleaf yellowhorn shell or carpopodium 65% are added, gleditsia sinensis 10%, the fleece-flower root 10%, Eclipta prostrata 10% is bitter
Ginseng 5%, is well mixed, and is ground into≤5mm particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:It is molten for 10% ethanol that 8 ratio adds content
Agent；With lemon acid for adjusting pH to 6, cellulase is added according to the ratio of feed liquid parts by weight 1%, 30 DEG C are heated up to, in mixer
Under the conditions of 100 revs/min of rotating speed, extraction time 90 minutes；It is warming up to 90 DEG C to be kept for 40 minutes, refluxing ethanol solvent, and realize
The deactivation of enzyme preparation, is cooled under normal temperature condition, is adjusted pH value to 7 with potassium hydroxide, is released filtrate standby.
3rd, the filter residue for extracting first time after filtrate, which is stored in extractor, carries out second of extraction, according to solid-liquid ratio 1:8
Ratio add content be 10% alcohol solvent；PH to 9 is adjusted with potassium hydroxide, according to the ratio alkali of feed liquid parts by weight 1%
Property protease, is heated up to 30 DEG C, under the conditions of 100 revs/min of mixer rotating speed, extraction time 90 minutes；It is warming up to 90 DEG C of guarantors
Hold 40 minutes, refluxing ethanol solvent, and the deactivation of enzyme preparation is realized, cool under normal temperature condition, use lemon acid for adjusting pH
Value releases filtrate standby to 7.
4th, extract solution twice is merged, according to 10:1 ratio adds 4A types zeolite and carries out decolorization, 3000 turns of rotating speed/
Separation of solid and liquid is carried out in the centrifuge of minute, filtered fluid is reclaimed.
5th, concentrate is made in vacuum -0.01MPa, steam pressure 0.5MPa in filtered fluid.
6th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 150 DEG C of EAT.
Embodiment 3
1st, according to parts by weight：Shinyleaf yellowhorn shell or carpopodium 55% are added, gleditsia sinensis 15%, the fleece-flower root 10%, Eclipta prostrata 10% is bitter
Ginseng 10%, is well mixed, and is ground into≤5mm particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:It is molten for 20% methanol that 10 ratio adds content
Agent；With salt acid for adjusting pH to 5, cellulase is added according to the ratio of feed liquid parts by weight 2%, 40 DEG C are heated up to, turned in mixer
Under the conditions of 60 revs/min of speed, extraction time 60 minutes；It is warming up to 85 DEG C to be kept for 35 minutes, methanol at reflux solvent, and realizes enzyme system
The deactivation of agent, is cooled under normal temperature condition, is adjusted pH value to 7 with sodium hydroxide, is released filtrate standby.
3rd, the filter residue for extracting first time after filtrate, which is stored in extractor, carries out second of extraction, according to solid-liquid ratio 1:10
Ratio add content be 20% alcohol solvent；PH to 10 is adjusted with potassium hydroxide, according to the ratio alkalescence of feed liquid parts by weight 1%
Protease, is heated up to 40 DEG C, under the conditions of 60 revs/min of mixer rotating speed, extraction time 60 minutes；It is warming up to 85 DEG C and keeps 35
Minute, refluxing ethanol solvent, and the deactivation of enzyme preparation is realized, cool under normal temperature condition, with lemon acid for adjusting pH value extremely
7, release filtrate standby.
4th, extract solution twice is merged, according to 10:2 ratio adds activated carbon and carries out decolorization, in 3000 revs/min of rotating speed
Separation of solid and liquid is carried out in the centrifuge of clock, filtered fluid is reclaimed.
5th, concentrate is made in vacuum -0.06MPa, steam pressure 0.3MPa in filtered fluid.
6th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 180 DEG C of EAT.
Embodiment 4
1st, according to parts by weight：Shinyleaf yellowhorn shell or carpopodium 60% are added, gleditsia sinensis 20%, the fleece-flower root 10%, Eclipta prostrata 5% is bitter
Ginseng 5%, is well mixed, and is ground into≤5mm particle.
2nd, above-mentioned raw materials are put into extractor, according to solid-liquid ratio 1:It is that 10% ethanol is molten that 12 ratio, which adds content,
Agent；With lemon acid for adjusting pH to 5, cellulase is added according to the ratio of feed liquid parts by weight 2.5%, 45 DEG C are heated up to, in stirring
Under the conditions of 40 revs/min of machine rotating speed, extraction time 80 minutes；It is warming up to 90 DEG C to be kept for 30 minutes, refluxing ethanol solvent, and in fact
The deactivation of existing enzyme preparation, is cooled under normal temperature condition, is adjusted pH value to 7 with sodium hydroxide, is released filtrate standby.
3rd, the filter residue for extracting first time after filtrate, which is stored in extractor, carries out second of extraction, according to solid-liquid ratio 1:12
Ratio add content be 10% methanol solvate；PH to 11 is adjusted with sodium hydroxide, according to the ratio alkali of feed liquid parts by weight 2%
Property protease, is heated up to 45 DEG C, under the conditions of 40 revs/min of mixer rotating speed, extraction time 80 minutes；It is warming up to 90 DEG C of holdings
30 minutes, methanol at reflux solvent, and the deactivation of enzyme preparation is realized, cool under normal temperature condition, use lemon acid for adjusting pH value
To 7, filtrate is released standby.
4th, extract solution twice is merged, according to 10:3 ratio adds activated carbon and carries out decolorization, in 3000 revs/min of rotating speed
Separation of solid and liquid is carried out in the centrifuge of clock, filtered fluid is reclaimed.
5th, concentrate is made in vacuum -0.05MPa, steam pressure 0.4MPa in filtered fluid.
6th, concentrate is obtained into powdered extract in the hig h-speed centrifugal spray drying at 200 DEG C of EAT.
The extract of above-mentioned all embodiments can use method used below：
Method one：2 grams of extract is taken, is applied on the hair soaked, is rubbed 1~2 minute, it is clean with warm water washing, i.e.,
It can reach anti-dandruff, antipruritic, black hair hair washing effect.
Method two：Take 2 grams of extract, 5mL commercial shampoos, (any one that selection is liked in person) is applied to and soaked
Hair on, rub 1~2 minute, it is clean with warm water washing, you can to reach anti-dandruff, antipruritic, black hair hair washing effect.
Embodiment 5
1st, 40 DEG C~60 DEG C warm water are added in pill tank, it is slow to add under conditions of 100 revs/min of mixer rotating speed
Enter the ethoxylated dodecyl alcohol sodium sulphate (AES) of parts by weight 5%, 0.1% guar gum, stirring is to being completely dissolved；
2nd, 45 DEG C are maintained the temperature to continue under conditions of stirring, 1% sodium chloride is added, 15% above-described embodiment is added
After 3 powdered extract, appropriate essence, stir 40 minutes；
3rd, it is cooled to after normal temperature, carries out filling, you can obtaining has anti-dandruff, antipruritic, black hair function Lignum Xanthoceratis extract
New shampoo.
Embodiment 6
Be that the addition of extract is different from the difference of embodiment 5, ethoxylated dodecyl alcohol sodium sulphate, guar gum and
The proportioning of sodium chloride is also different from embodiment 5.The addition of the present embodiment extract is 20%, ethoxylated dodecyl alcohol sulfuric acid
The addition of sodium, guar gum and sodium chloride is respectively 7%, 0.2%, 2%.Above percentage is on the basis of water inventory of having one's hair wash.
Comparative example 1
When preparing extract in comparative example 1, raw material is only gleditsia sinensis, the fleece-flower root, Eclipta prostrata and kuh-seng in mass ratio 3:2:2:2
Mixing, remaining is identical with comparative example 1.
Anti-dandruff efficacy assessments
35 subjects (scurf piece number is more than 3 in subject transdermal region every square centimeter) are randomly selected, by special
Industry doctor is checked, dandruff most serious position at two is chosen from the head of every subject, and all subjects use own control,
Most serious point is respectively using two kinds of different shampoos (being respectively embodiment 5 and comparative example 1) at two chosen, before experiment and two
Zhou Hou, carry out chaff Pi chlosma culture after 4 weeks and count clump count.
Sample collection and culture：In the region to be measured of each subject, appropriate physiological saline is dipped with sterile cotton swab, per area
Scalp is cleaned three times in domain repeatedly, often locates totally nine times, and the dandruff cotton swab under cleaning is put in 1mL physiological saline sterilization centrifuge tube, warp
It is seeded to after concussion is uniform on the chloramphenicol Sha Baoshi agar glucose culture dishes containing 5% sesame oil, 37 DEG C of insulating box culture 7-
10 days, all bacterium colonies grown observed the single bacterium colony row Gram's staining grown on colonial morphology, and picking culture medium every other day
Microscopy is determined whether for chlosma, unified to detect scalp chlosma clump count every square centimeter within 8th day.
As a result
As a result show, clump count, which is compared, after comparative example 1 is tested two weeks reduces 10.1% before experiment, and with statistics
Clump count reduces 52.2% before comparing experiment after meaning, experiment four weeks.Before clump count is compared to experiment after embodiment 5 is tested two weeks
20.3% is reduced, and with statistical significance, tests clump count after four weeks and reduces 80.7% before comparing experiment, and have
It is statistically significant.The product effect of other embodiments is have detected simultaneously, it is as a result consistent with embodiment 5.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of hair care exterior-applied article being made of Lignum Xanthoceratis extract, it is characterised in that obtained after being extracted including following components
Extract：Shinyleaf yellowhorn shell/carpopodium, gleditsia sinensis, the fleece-flower root, Eclipta prostrata and kuh-seng, and the weight ratio of above component is：50~65:
10~20:5~10:5~10:5~10.
2. hair care exterior-applied article according to claim 1, it is characterised in that shinyleaf yellowhorn shell/carpopodium, gleditsia sinensis, the fleece-flower root, non-irrigated lotus
Grass and the weight ratio of kuh-seng are：55~60:15~20:5~10:5~10:5~10.
3. hair care exterior-applied article according to claim 1 or 2, it is characterised in that the extracting method of the extract is：
Using 10%~30% methanol or 10%~30% ethanol as solvent, solid-liquid ratio is 1:8~1:15, pH value of solution is 4~6, plus
Enter the cellulase for 1~3wt% that weight is reaction solution, be heated up to 30 DEG C~50 DEG C, carry out first time solvent extraction, mistake
Filter, collects filter residue and filtrate；
10%~30% methanol or 10%~30% ethanol are added into the filter residue, solid-liquid ratio is 1:8~1:15, pH value of solution is
9~11, alkali protease of the weight for 1~3wt% of reaction solution is added, 30 DEG C~50 DEG C are heated up to, carried out molten for the second time
Agent is extracted, filtering, is collected filtrate and is merged with the filtrate that the first time solvent extraction is obtained.
4. hair care exterior-applied article according to claim 3, it is characterised in that also include after second of solvent extraction：
By the filtrate regulation pH after the merging to neutral, decolouring, concentration, dry.
5. hair care exterior-applied article according to claim 4, it is characterised in that preferably, the method for the decolouring is：To waiting to take off
The activated carbon or zeolite of 0.1~0.5 times of its weight are added in the solution of color, completes to filter after absorption.
6. hair care exterior-applied article according to claim 4, it is characterised in that the method for the concentration is：In vacuum -0.01
Water content 40wt%~50wt% concentrate is made under~-0.092MPa, 0.1~0.5MPa of steam pressure；
The method of the drying is：It is spray-dried at 150 DEG C~220 DEG C of EAT.
7. hair care exterior-applied article according to claim 1, it is characterised in that the hair care exterior-applied article is shampoo, and also
Including ethoxylated dodecyl alcohol sodium sulphate, guar gum and sodium chloride.
8. hair care exterior-applied article according to claim 7, it is characterised in that the weight percentage of the extract is 15~
20%.
9. hair care exterior-applied article according to claim 7, it is characterised in that preferably, the ethoxylated dodecyl alcohol sulphur
The weight ratio of sour sodium, guar gum and sodium chloride is 5~7:0.1~0.2:1~2.
10. the preparation method of the hair care exterior-applied article described in claim 7, it is characterised in that to the water that temperature is 40 DEG C~60 DEG C
Middle addition ethoxylated dodecyl alcohol sodium sulphate, guar gum, sodium chloride, the extract and remaining raw material, mixing are produced.
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| CN110693786A (en) * | 2019-11-15 | 2020-01-17 | 蒙建玲 | Traditional Chinese medicine hair conditioner and preparation method thereof |
| CN118844537A (en) * | 2024-09-25 | 2024-10-29 | 山东百德生物科技有限公司 | Animal protein product composed of edible amino acid enzymes and preparation process thereof |
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Application publication date: 20170922 |