CN107163866B - Medical ultraviolet-curing water-based conductive pressure-sensitive adhesive - Google Patents

Abstract

A medical ultraviolet curing water-based conductive pressure-sensitive adhesive is prepared by the following steps: 1) preparing a water-soluble polymer material or chitosan into an aqueous solution with the mass concentration of 1-10%; 2) adding acrylic acid, hydroxypropyl acrylate, a cross-linking agent, a photoinitiator, glycerol and sodium hydroxide into the solution, and stirring until the acrylic acid, the hydroxypropyl acrylate, the cross-linking agent, the photoinitiator, the glycerol and the sodium hydroxide are completely dissolved; 3) coating the mixture into a wet film with the thickness of 1.0-2.0mm by a paint film coater; 4) and irradiating under the lamp tube of the ultraviolet curing machine and then taking out to obtain the ultraviolet curing agent. All the raw materials are water-soluble, and water is used as a solvent, so that the environmental pollution and the in-vitro cytotoxicity and sensitization of the product are reduced; the cellulose matrix or the chitosan matrix is natural and environment-friendly, and is beneficial to adjusting the coating viscosity of the pressure-sensitive adhesive; the adoption of the water-based photoinitiator is beneficial to avoiding the generation of foul smell after the decomposition of the oil-soluble initiator; the UV light is utilized to irradiate and quickly cure, the curing speed is extremely high, and the production efficiency of the product is extremely high.

Description

A medical UV-curable water-based conductive voltage-sensitive adhesive

technical field

The invention belongs to the technical field of polymer materials, in particular to a medical UV-curable water-based conductive voltage-sensitive adhesive.

Background technique

In recent years, electronic medical devices such as high-impedance electromyography, electrocardiograph, gastroenterograph, electrical stimulator, and high-frequency electrosurgery have been widely used in the diagnosis and treatment of diseases. It reflects the bioelectrical signals of the human body, so the electrodes are required to be conductive and to be in close contact with the human epidermis. Conductive pressure-sensitive adhesives are both pressure-sensitive and conductive, and are viscoelastic materials that are activated by finger pressure in the absence of solvents and remain viscous. Under the condition of light acupressure, the adhesive surface can be instantly adhered to the surface of human skin, and when combined with special medical equipment, it can transmit current signals well. Due to its good cohesion and non-drying properties, it can be easily peeled off from the skin at the end of use and leaves no residue on the skin surface, so it has broad application prospects.

However, the existing conductive voltage-sensitive adhesive manufacturing process is not environmentally friendly enough, and the finished product has certain cytotoxicity and sensitization environmental protection, which limits the application of the conductive voltage-sensitive adhesive to a certain extent.

SUMMARY OF THE INVENTION

In order to solve the problems in the prior art that the production process of the conductive voltage-sensitive adhesive is not environmentally friendly, and the finished product has certain cytotoxicity and sensitization environmental protection, thus limiting the application of the conductive voltage-sensitive adhesive to a certain extent, the present invention provides a medical ultraviolet Light-curing water-based conductive voltage-sensitive adhesive.

A medical UV-curable water-based conductive voltage-sensitive adhesive is prepared by the following steps:

1), fully dissolve water-soluble polymer materials such as sodium carboxymethyl cellulose or hydroxyethyl cellulose in water overnight or dissolve chitosan in an acetic acid solution with a volume ratio of 1% to obtain a mass concentration of 1-10% aqueous solution;

2), get the above solution 10-50mL and add acrylic acid 5-30g, hydroxypropyl acrylate 1-20g, crosslinking agent 0.1-1, photoinitiator 0.1-2.0, glycerol 5-30g and sodium hydroxide 0.1-1.0 g, stir until all dissolved;

3), use a paint film applicator to coat to obtain a wet film with a thickness of 1.0-2.0 mm;

4), place the above wet film at 10-40 cm below the lamp tube of the ultraviolet curing machine, and take it out after irradiating for 5-120 seconds to obtain the water-based conductive pressure-sensitive adhesive.

Further, the cross-linking agent is a water-soluble cross-linking agent such as trimethylolpropane trimethacrylate.

Further, the photoinitiator is an Irgacure series water-soluble initiator.

Further, the ultraviolet curing machine is a cold light type ultraviolet curing machine with a power of 500-2000W. The lamp tube of the ultraviolet curing machine is a high pressure mercury lamp.

Beneficial effects: all the raw materials of the present invention are water-soluble, and water is used as the solvent, which reduces environmental pollution and the in vitro cytotoxicity and sensitization of the product; the cellulose matrix or the chitosan matrix is natural and environmentally friendly, and is conducive to regulating pressure. The coating viscosity of the sensitive adhesive; the use of water-based photoinitiator is beneficial to avoid the bad smell generated by the decomposition of the oil-soluble initiator; the use of UV light irradiation to quickly cure, the curing speed is extremely fast, and the product production efficiency is extremely high.

Detailed ways

Example 1

Chitosan was dissolved in an acetic acid solution with a volume ratio of 1% to obtain an aqueous solution with a mass concentration of 2%. (2) Take 40 mL of the above solution, add 30 g of acrylic acid, 15 g of hydroxypropyl acrylate, 0.7 g of crosslinking agent, 0.8 g of photoinitiator, 30 g of glycerol, and 0.8 g of sodium hydroxide, and stir until all solids are dissolved. (3) Coating with a paint film coater to obtain a wet film with a thickness of 2.0 mm. (4) Place the wet film at 30 cm below the lamp tube of a cold light type ultraviolet curing machine with a power of 2000W, and take it out after irradiating for 50 seconds to obtain a conductive pressure-sensitive adhesive.

Example 2

(1) A water-soluble polymer material such as sodium carboxymethyl cellulose is fully dissolved in water overnight to obtain an aqueous solution with a mass concentration of 3%. (2) Take 20 mL of the above solution, add 10 g of acrylic acid, 10 g of hydroxypropyl acrylate, 0.5 g of crosslinking agent, 0.4 g of photoinitiator, 20 g of glycerol, and 0.2 g of sodium hydroxide, and stir until all solids are dissolved. (3) Coating with a paint film applicator to obtain a wet film with a thickness of 1.0 mm. (4) The wet film is placed 20 cm below the lamp tube of a cold light type ultraviolet curing machine with a power of 1000W, and after irradiating for 80 seconds, it is taken out to obtain a conductive pressure-sensitive adhesive.

Example 3

(1) The water-soluble polymer material hydroxyethyl cellulose is fully dissolved in water overnight to obtain an aqueous solution with a mass concentration of 5%. (2) Take 30 mL of the above solution, add 15 g of acrylic acid, 20 g of hydroxypropyl acrylate, 0.7 g of crosslinking agent, 0.6 g of photoinitiator, 25 g of glycerol, and 0.4 g of sodium hydroxide, and stir until all solids are dissolved. (3) Coating with a paint film applicator to obtain a wet film with a thickness of 1.5 mm. (4) Place the wet film at 25 cm below the lamp tube of a cold light type ultraviolet curing machine with a power of 1500W, and take it out after irradiating for 60 seconds to obtain a conductive pressure-sensitive adhesive.

Example 4

(1) Dissolving chitosan in an acetic acid solution with a volume ratio of 1% to obtain an aqueous solution with a mass concentration of 1%. (2) Take 10 mL of the above solution, add 5 g of acrylic acid, 1 g of hydroxypropyl acrylate, 0.1 g of crosslinking agent, 0.1 g of photoinitiator, 5 g of glycerol, and 0.1 g of sodium hydroxide, and stir until all the solids are dissolved. (3) Coating with a paint film applicator to obtain a wet film with a thickness of 1.0 mm. (4) The wet film is placed 10 cm below the lamp tube of a cold light type ultraviolet curing machine with a power of 500 W, and after irradiating for 5 seconds, the pressure-sensitive adhesive with conductivity is taken out.

Example 5

The hydroxyethyl cellulose was fully dissolved in water overnight to obtain an aqueous solution with a mass concentration of 10%. (2) Take 50 mL of the above solution and add 30 g of acrylic acid, 20 g of hydroxypropyl acrylate, 1 g of crosslinking agent, 2.0 g of photoinitiator, 30 g of glycerol, and 1 g of sodium hydroxide, and stir until all solids are dissolved. (3) Coating with a paint film coater to obtain a wet film with a thickness of 2.0 mm. (4) The wet film is placed 40 cm below the lamp tube of a cold light type ultraviolet curing machine with a power of 2000W, and after irradiating for 120 seconds, it is taken out to obtain a conductive pressure-sensitive adhesive.

In order to verify the performance of the medical UV-curable water-based conductive voltage-sensitive adhesive of the present invention, the following tests were done:

1. Determination of electrical contact performance

The medical UV-curable water-based conductive voltage-sensitive adhesive prepared in Examples 1-5 was coated on aluminum foil to form a pole plate, and then the entire area of the pole plate was firmly placed on a 20cm×30cm metal plate, and a precision LCR measuring instrument was used. AC impedance was measured at a frequency of 1000 kHz. The results are shown in Table 1.

2. Adhesion test

The medical UV-curable water-based conductive voltage-sensitive adhesive prepared in Examples 1-5 was coated on aluminum foil to form a polar plate, and then tested according to GB/T4851-2014, and the pre-cut 25mm × 60mm sample was attached to the test. The surface of the board is rolled and bonded. Within 1min, first place the entire test specimen lightly on the test stand, so that the free end of the specimen is vertical, and then lightly apply the weight to the fixture. Record the time required for the specimen to completely separate from the test plate. The results are shown in Table 1.

3. 180° peel strength test

The medical UV-curable water-based conductive voltage-sensitive adhesive prepared in Examples 1-5 was coated on aluminum foil to form a polar plate, and then tested according to GB/T2792-2014, the peeling speed was 300mm/min, and the average peeling force was recorded. The results are shown in Table 1:

Table 1 Performance test results of Examples 1-5

Claims (3)

1. a medical UV-curable water-based conductive voltage-sensitive adhesive, is characterized in that, adopts the following steps to prepare: 1), fully dissolve the water-soluble polymer material in water overnight or dissolve chitosan in an acetic acid solution with a volume ratio of 1% to obtain an aqueous solution with a mass concentration of 1-10%; 2), get the above solution 10-50mL and add acrylic acid 5-30g, hydroxypropyl acrylate 1-20g, crosslinking agent 0.1-1g, photoinitiator 0.1-2.0g, glycerol 5-30g and sodium hydroxide 0.1- 1.0g, stir until all dissolved; 3), use a paint film applicator to coat to obtain a wet film with a thickness of 1.0-2.0 mm; 4), place the above-mentioned wet film at 10-40cm below the lamp tube of the UV curing machine, and take out after 5-120 seconds of irradiation to obtain a water-based conductive pressure-sensitive adhesive; The water-soluble polymer material in the step 1) is sodium carboxymethyl cellulose or hydroxyethyl cellulose; Described photoinitiator is Irgacure series water-soluble initiator. 2 . The medical UV-curable water-based conductive voltage-sensitive adhesive according to claim 1 , wherein the crosslinking agent is trimethylolpropane trimethacrylate. 3 . 3. The medical UV-curable water-based conductive voltage-sensitive adhesive according to claim 1, wherein the UV curing machine is a cold light type UV curing machine with a power of 500-2000W.