CN107161936A - The production technology of the big transfusion of vial - Google Patents
The production technology of the big transfusion of vial Download PDFInfo
- Publication number
- CN107161936A CN107161936A CN201710425079.6A CN201710425079A CN107161936A CN 107161936 A CN107161936 A CN 107161936A CN 201710425079 A CN201710425079 A CN 201710425079A CN 107161936 A CN107161936 A CN 107161936A
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- Prior art keywords
- bottle
- infusion bottle
- glass infusion
- glass
- production technology
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 25
- 238000005516 engineering process Methods 0.000 title claims abstract description 19
- 238000001802 infusion Methods 0.000 claims abstract description 88
- 239000011521 glass Substances 0.000 claims abstract description 85
- 239000003814 drug Substances 0.000 claims abstract description 62
- 230000001954 sterilising effect Effects 0.000 claims abstract description 56
- 238000011049 filling Methods 0.000 claims abstract description 46
- 229940079593 drug Drugs 0.000 claims abstract description 41
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 238000004140 cleaning Methods 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 18
- 238000007689 inspection Methods 0.000 claims abstract description 13
- 238000004806 packaging method and process Methods 0.000 claims abstract description 13
- 238000007664 blowing Methods 0.000 claims abstract description 9
- 239000003651 drinking water Substances 0.000 claims abstract description 9
- 235000020188 drinking water Nutrition 0.000 claims abstract description 9
- 239000008213 purified water Substances 0.000 claims abstract description 9
- 239000008215 water for injection Substances 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims description 24
- 239000002994 raw material Substances 0.000 claims description 23
- 239000012535 impurity Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 238000013329 compounding Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 4
- 238000009509 drug development Methods 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 17
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 16
- 239000004115 Sodium Silicate Substances 0.000 description 9
- 229920000728 polyester Polymers 0.000 description 9
- 229910010271 silicon carbide Inorganic materials 0.000 description 9
- 235000019795 sodium metasilicate Nutrition 0.000 description 9
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 9
- 229910052911 sodium silicate Inorganic materials 0.000 description 9
- 229910052593 corundum Inorganic materials 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000000835 fiber Substances 0.000 description 8
- 239000000377 silicon dioxide Substances 0.000 description 8
- 229910001845 yogo sapphire Inorganic materials 0.000 description 8
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000006004 Quartz sand Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- VDGJOQCBCPGFFD-UHFFFAOYSA-N oxygen(2-) silicon(4+) titanium(4+) Chemical compound [Si+4].[O-2].[O-2].[Ti+4] VDGJOQCBCPGFFD-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/24—Devices for supporting or handling bottles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0073—Sterilising, aseptic filling and closing
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a kind of production technology of the big transfusion of vial, comprise the following steps：Glass infusion bottle is put on bottling station, glass infusion bottle takes out bottle blowing through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air, completes the cleaning to glass infusion bottle；Glass infusion bottle after cleaning is transferred to filling station, the temperature control of liquid drug filling rear tamponade, rolls lid at 40~60 DEG C in pouring process；Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and sterilized, sterilising temp is 100~150 DEG C, and sterilization time is 10~100min；Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.The present invention can be effectively ensured glass infusion bottle high-tech product multi items and frequently alternately produce, to adapt to new markets situation glass infusion bottle to therapeutic type drug development, glass infusion bottle infusion products quality is improved, and every quality index is high, production efficiency is high, and cost is low.
Description
Technical field
The present invention relates to the production technology in infusion bottle field, more particularly to a kind of big transfusion of vial.
Background technology
Big transfusion is one of five major class important preparations in China's medicine, is clinically widely used product.It is existing
Big transfusion in technology is mainly packed using glass infusion bottle, because glass infusion bottle has powder charge very safe etc. numerous
Advantage.First, glass infusion bottle is extremely low to gas and moisture content permeability, it is possible to long term storage medicine company；Secondly, glass transfusion
Bottle is good with drug compatibility, does not adsorb medicine, and will not be reacted with medicine and separate out material, and bottle does not have in itself to come off
Layer, so using very safe；Again, glass infusion bottle is different from plastic bottle, and glass infusion bottle will be free from plasticizer, glass
Bottle of infusing is nontoxic；Again, glass infusion bottle adaptive temperature scope is wide, available for high-temperature sterilization.But current glass infusion bottle
The production cost infused greatly is high, efficiency is low.
The content of the invention
It is an object of the invention to provide a kind of production technology of the big transfusion of vial, it can solve the problem that existing glass infusion bottle is big
The low technical problem of production cost height, the efficiency of infusing.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of production technology of the big transfusion of vial, comprises the following steps：
Glass infusion bottle takes out bottle blowing, completion pair through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air
The cleaning of glass infusion bottle；
Glass infusion bottle after cleaning is transferred to filling station, the temperature control of liquid drug is 40 in pouring process
~60 DEG C, filling rear tamponade, roll lid；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and sterilized, sterilising temp is 100~150 DEG C,
Sterilization time is 10~100min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
Preferably, the water in the liquid drug is made using laminated filtering mode.
Preferably, the sterilization method is autoclaving or water-bath sterilization method.
Preferably, the glass infusion bottle is transmitted by crawler belt, completes cleaning, liquid drug, sealing, sterilizing, lamp
Inspection, packaging.
Preferably, the mode of the liquid drug is constant-pressure tank powder charge liquid.
Preferably, the glass infusion bottle is cleaned under air-proof condition, filling, tamponade, rolls lid.
Preferably, the capacity of the glass infusion bottle is 50~500mL.
Preferably, the preparation process of the liquid drug is done to be put into after raw material cleaning dedusting removal of impurities in drying box
It is dry, weighed on demand after having dried, load weighted raw material is subjected to concentrated compounding, after coarse filtration, be diluted, refined filtration, produced.
The beneficial effects of the present invention are：
The invention provides a kind of production technology of the big transfusion of vial, it is possible to achieve online cleaning and sterilization, equipment are clear
More than 99.5% can be brought up to Disinfection Effect by washing.Glass infusion bottle transfusion high-tech product multi items can be effectively ensured frequently to hand over
For production, to adapt to new markets situation glass infusion bottle to therapeutic type drug development, glass infusion bottle infusion products quality is improved,
And every quality index is high, and production efficiency is high, and cost is low.
Embodiment
A kind of production technology for the big transfusion of vial that the present invention is provided, comprises the following steps：
Glass infusion bottle takes out bottle blowing, completion pair through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air
The cleaning of glass infusion bottle；
Glass infusion bottle after cleaning is transferred to filling station, the temperature control of liquid drug is 40 in pouring process
~60 DEG C, filling rear tamponade, roll lid；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and sterilized, sterilising temp is 100~150 DEG C,
Sterilization time is 10~100min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
Above-mentioned technical proposal, it is possible to achieve online cleaning and sterilization, equipment effect of cleaning and disinfection can bring up to 99.5%
More than.Glass infusion bottle transfusion high-tech product multi items can be effectively ensured frequently alternately to produce, to adapt to new markets situation glass
Glass infusion bottle is to therapeutic type drug development.Glass infusion bottle infusion products quality is improved, so as to ensure the safe energy of infusion medicine
Power is built.Every quality index is qualified and improves, and also to accomplish that safe and reliable, clean environment firendly, cost are low.
In order to improve the cleannes of the big transfusion of glass infusion bottle, it is to avoid pollutant and impurity, in an embodiment of the present invention,
Water in liquid drug is made using laminated filtering mode, and the filter type is filtered with conventional quartz sand and charcoal absorption is filtered
Mode is compared, and water use efficiency can be made to improve more than 5%, the service life of two-pass reverse osmosis film can also be improved, and is improved by 2 years
It by 5 years, can also reduce that the bed processing of activated carbon microbial growth is not in place to cause process water to pollute, effectively improve process water
Quality.
In an embodiment of the present invention, the mode of liquid drug is constant-pressure tank powder charge liquid, when the canning meanses use pressure
Between the filling principle of formula, the product of passage time and flow velocity carrys out metering filling, in order to ensure high yield, when avoiding because of quick liquid filling again
Produce decoction foam；Filling time is accurately controlled by computer, and precision is 0.01 second, and accurate measurement, no bottle is not filling.
In an embodiment of the present invention, sterilization method is autoclaving or water-bath sterilization method.
In an embodiment of the present invention, glass infusion bottle is transmitted by crawler belt, complete cleaning, liquid drug, sealing,
Sterilizing, lamp inspection, packaging.
In order to ensure the safety of infusion medicine, in an embodiment of the present invention, the big transfusion of glass infusion bottle is in cleaning, filling
Carried out when dress, sealing under air-proof condition.
In an embodiment of the present invention, the capacity of glass infusion bottle is 50~500mL.
In an embodiment of the present invention, the preparation process of liquid drug is to be put into after raw material cleans dedusting removal of impurities in drying box
It is dried, is weighed on demand after having dried, load weighted raw material is subjected to concentrated compounding, after coarse filtration, be diluted, refined filtration, i.e.,
.
It should be noted that anti-fragility, resistance to elevated temperatures in order to improve glass infusion bottle, glass infusion bottle is with titanium dioxide
Silicon, sodium metasilicate, alundum (Al2O3), polyester fiber, carborundum are raw material, the mutual cooperation of this five kinds of raw materials so that glass is infused
The big transfusion of bottle has excellent anti-fragility, resistance to elevated temperatures.Additionally by using cleaning, filling, sealing, sterilizing, lamp inspection, packaging
Etc. the big transfusion of technique productions glass infusion bottle, production technology is simplified, cost is reduced, the big transfusion of glass infusion bottle is improved
Quality.
Silica is used for the hardness for improving the big transfusion of glass infusion bottle.In the present invention, the parts by weight of silica
For 60~80 parts；In an embodiment of the present invention, the parts by weight of silica are 65~75 parts.
Sodium metasilicate is used for the anti-fragility for improving the big transfusion of glass infusion bottle.In the present invention, the parts by weight of sodium metasilicate are 5
~12 parts；In other embodiments of the invention, the parts by weight of sodium metasilicate are 8~12 parts.
Alundum (Al2O3) is used for the resistance to elevated temperatures for improving the big transfusion of vial.In the present invention, the weight of alundum (Al2O3)
It is 10~20 parts to measure number；In an embodiment of the present invention, the parts by weight of alundum (Al2O3) are 14~16 parts.
Polyester fiber is used for the impact strength and elongation at break for improving the big transfusion of vial.In the present invention, polyester is fine
The parts by weight of dimension are 15~24 parts；In an embodiment of the present invention, the parts by weight of polyester fiber are 18~21 parts.
Carborundum is used for the chemical stability for improving the big transfusion of vial.In the present invention, the parts by weight of carborundum are 3
~12 parts；In an embodiment of the present invention, the parts by weight of carborundum are 6~9 parts.
In order to improve the uniformity of the big transfusion of vial, in an embodiment of the present invention, the big transfusion raw material of vial is ground
It is that particle diameter polydispersity index is less than 1.05 to grind index.
In addition, in an embodiment of the present invention, cleaning equipment and sterilizing equipment decontaminating apparatus are the sterilization system on line of on-line cleaning equipment
Equipment, can bring up to 99.5% by equipment effect of cleaning and disinfection, and the high-new production of glass infusion bottle transfusion can be effectively ensured
Product multi items are frequently alternately produced, to adapt to new markets situation glass infusion bottle to therapeutic type drug development.Improve vial big
Product quality in transfusion, so as to ensure infusion medicine security capabilities construction.
In order to further illustrate the present invention, the production work of the big transfusion of vial provided with reference to embodiments the present invention
Skill is described in detail.
Embodiment 1
Glass infusion bottle takes out bottle blowing, completion pair through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air
The cleaning of glass infusion bottle；
Glass infusion bottle after cleaning is transferred to constant pressure filling station and carries out constant pressure filling, the filling medicine in pouring process
The temperature control of liquid filling rear tamponade, rolls lid at 40 DEG C；Wherein the preparation process of liquid drug is that raw material is cleaned after dedusting removal of impurities
It is put into drying box and is dried, weighed on demand after having dried, load weighted raw material is carried out after concentrated compounding, coarse filtration, carries out
Dilution, refined filtration, produce liquid drug；The water that liquid drug is used is made using laminated filtering mode；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and carry out pressure sterilizing, sterilising temp is 120 DEG C,
Sterilization time is 20min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
Glass infusion bottle includes the silica of 60 parts by weight, the sodium metasilicate of 5 parts by weight, three oxidations two of 10 parts by weight
The carborundum of aluminium, the polyester fiber of 15 parts by weight and 3 parts by weight.
The equipment effect of cleaning and disinfection that embodiment 1 produces the obtained big transfusion of glass infusion bottle can bring up to 99.5%,
Transparency 98.9%, impact strength is 65J/m, and the high temperature that can be born is 193 DEG C.
Embodiment 2
Glass infusion bottle takes out bottle blowing, completion pair through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air
The cleaning of glass infusion bottle；
Glass infusion bottle after cleaning is transferred to constant pressure filling station and carries out constant pressure filling, the filling medicine in pouring process
The temperature control of liquid filling rear tamponade, rolls lid at 60 DEG C；Wherein the preparation process of liquid drug is that raw material is cleaned after dedusting removal of impurities
It is put into drying box and is dried, weighed on demand after having dried, load weighted raw material is carried out after concentrated compounding, coarse filtration, carries out
Dilution, refined filtration, produce liquid drug；The water that liquid drug is used is made using laminated filtering mode；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and carry out pressure sterilizing, sterilising temp is 130 DEG C,
Sterilization time is 22min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
The preparing raw material of glass infusion bottle includes the silica of 80 parts by weight, the sodium metasilicate of 12 parts by weight, 20 weight
Part alundum (Al2O3), the carborundum of the polyester fiber of 24 parts by weight and 12 parts by weight.
The equipment effect of cleaning and disinfection that embodiment 2 produces the obtained big transfusion of glass infusion bottle is 99.5%, transparency
99.3%, impact strength is 63J/m, and the high temperature that can be born is 189 DEG C.
Embodiment 3
Glass infusion bottle is put on bottling station, glass infusion bottle warp, drinking water wash bottle, purified water wash bottle, injection
Crystal washes, pure air takes out bottle blowing, completes the cleaning to glass infusion bottle；
Glass infusion bottle after cleaning is transferred to constant pressure filling station and carries out constant pressure filling, the filling medicine in pouring process
The temperature control of liquid filling rear tamponade, rolls lid at 45 DEG C；Wherein the preparation process of liquid drug is that raw material is cleaned after dedusting removal of impurities
It is put into drying box and is dried, weighed on demand after having dried, load weighted raw material is carried out after concentrated compounding, coarse filtration, carries out
Dilution, refined filtration, produce liquid drug；The water that liquid drug is used is made using laminated filtering mode；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and carry out pressure sterilizing, sterilising temp is 140 DEG C,
Sterilization time is 18min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
The preparing raw material of glass infusion bottle includes the silica of 65 parts by weight, the sodium metasilicate of 8 parts by weight, 14 parts by weight
Alundum (Al2O3), the carborundum of the polyester fiber of 18 parts by weight and 6 parts by weight.
The equipment effect of cleaning and disinfection that embodiment 3 produces the obtained big transfusion of glass infusion bottle is 99.6%, transparency
99.1%, impact strength is 67J/m, and the high temperature that can be born is 184 DEG C.
Embodiment 4
Glass infusion bottle takes out bottle blowing, completion pair through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air
The cleaning of glass infusion bottle；
Glass infusion bottle after cleaning is transferred to constant pressure filling station and carries out constant pressure filling, the filling medicine in pouring process
The temperature control of liquid filling rear tamponade, rolls lid at 55 DEG C；Wherein the preparation process of liquid drug is that raw material is cleaned after dedusting removal of impurities
It is put into drying box and is dried, weighed on demand after having dried, load weighted raw material is carried out after concentrated compounding, coarse filtration, carries out
Dilution, refined filtration, produce liquid drug；The water that liquid drug is used is made using laminated filtering mode；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and carry out pressure sterilizing, sterilising temp is 150 DEG C,
Sterilization time is 25min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
The preparing raw material of glass infusion bottle includes the silica of 75 parts by weight, the sodium metasilicate of 12 parts by weight, 15 weight
Part alundum (Al2O3), the carborundum of the polyester fiber of 21 parts by weight and 8 parts by weight.
The equipment effect of cleaning and disinfection that embodiment 4 produces the obtained big transfusion of vial is 99.7%, transparency
99.0%, impact strength is 64J/m, and the high temperature that can be born is 193 DEG C.
Embodiment 5
Glass infusion bottle takes out bottle blowing, completion pair through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air
The cleaning of glass infusion bottle；
Glass infusion bottle after cleaning is transferred to constant pressure filling station and carries out constant pressure filling, the filling medicine in pouring process
The temperature control of liquid filling rear tamponade, rolls lid at 50 DEG C；Wherein the preparation process of liquid drug is that raw material is cleaned after dedusting removal of impurities
It is put into drying box and is dried, weighed on demand after having dried, load weighted raw material is carried out after concentrated compounding, coarse filtration, carries out
Dilution, refined filtration, produce liquid drug；The water that liquid drug is used is made using laminated filtering mode；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and carry out pressure sterilizing, sterilising temp is 135 DEG C,
Sterilization time is 15min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
The preparing raw material of glass infusion bottle includes the silica of 70 parts by weight, the sodium metasilicate of 10 parts by weight, 16 weight
Part alundum (Al2O3), the carborundum of the polyester fiber of 20 parts by weight and 9 parts by weight.
The equipment effect of cleaning and disinfection that embodiment 5 produces the obtained big transfusion of vial is 99.6%, transparency
99.2%, impact strength is 68J/m, and the high temperature that can be born is 191 DEG C.
Disclosed above is only specific implementation of the patent example, but this patent is not limited to this, for the general of this area
For logical technical staff, under the premise without departing from the principles of the invention, the deformation made should be regarded as belonging to the scope of the present invention.
Claims (8)
1. a kind of production technology of the big transfusion of vial, it is characterised in that comprise the following steps：
Glass infusion bottle takes out bottle blowing, complete pair glass through drinking water wash bottle, purified water wash bottle, water for injection fine purifiation, pure air
The cleaning of infusion bottle；
Glass infusion bottle after cleaning is transferred to filling station, the temperature control of liquid drug is 40~60 in pouring process
DEG C, filling rear tamponade, roll lid；
Finished filling and tamponade, the medicine bottle that rolls lid are put into sterilizing cabinet and sterilized, sterilising temp is 100~150 DEG C, sterilizing
Time is 10~100min；
Medicine bottle after sterilizing is examined after lamp inspection, packaging, the big transfusion of glass infusion bottle is produced.
2. production technology as claimed in claim 1, it is characterised in that the water in the liquid drug uses laminated filtering mode
It is made.
3. production technology as claimed in claim 1, it is characterised in that the sterilization method is autoclaving or water-bath sterilization
Method.
4. production technology as claimed in claim 1, it is characterised in that the glass infusion bottle is transmitted by crawler belt, complete
Into cleaning, liquid drug, sealing, sterilizing, lamp inspection, packaging.
5. production technology as claimed in claim 4, it is characterised in that the mode of the liquid drug is constant-pressure tank powder charge liquid.
6. production technology as claimed in claim 1, it is characterised in that the glass infusion bottle is carried out clearly under air-proof condition
Wash, filling, tamponade, roll lid.
7. production technology as claimed in claim 1, it is characterised in that the capacity of the glass infusion bottle is 50~500mL.
8. production technology as claimed in claim 1, it is characterised in that the preparation process of the liquid drug is that raw material cleaning is removed
It is put into drying box and is dried after dirt removal of impurities, weighed on demand after having dried, load weighted raw material is subjected to concentrated compounding, coarse filtration
Afterwards, be diluted, refined filtration, produce.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710425079.6A CN107161936A (en) | 2017-06-06 | 2017-06-06 | The production technology of the big transfusion of vial |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710425079.6A CN107161936A (en) | 2017-06-06 | 2017-06-06 | The production technology of the big transfusion of vial |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107161936A true CN107161936A (en) | 2017-09-15 |
Family
ID=59824769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710425079.6A Pending CN107161936A (en) | 2017-06-06 | 2017-06-06 | The production technology of the big transfusion of vial |
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| CN (1) | CN107161936A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108969776A (en) * | 2018-07-19 | 2018-12-11 | 广州风行乳业股份有限公司 | A kind of method for cleaning and disinfecting of condensed milk vial |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Application publication date: 20170915 |