CN107149077A - Effervescent tablet and preparation method thereof after one kind is run - Google Patents
Effervescent tablet and preparation method thereof after one kind is run Download PDFInfo
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- CN107149077A CN107149077A CN201610115916.0A CN201610115916A CN107149077A CN 107149077 A CN107149077 A CN 107149077A CN 201610115916 A CN201610115916 A CN 201610115916A CN 107149077 A CN107149077 A CN 107149077A
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- parts
- vitamin
- extract
- effervescent tablet
- sugar alcohol
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
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Abstract
Effervescent tablet and preparation method thereof after being run the invention discloses one kind, the effervescent tablet main component is by 18 parts of Fructus Rubi extract, 18 parts of dried tremella extract, 1 12 parts of haw thorn extract, 20 45 parts of citric acid, 15 40 parts of sodium acid carbonate, 0.5 4 parts of phosphatidylserine, 0.5 4 parts of alkalization cocoa power, 18 parts of saleratus, 20 45 parts of sugar alcohol, 0.5 3 parts of magnesium stearates, 0.000028 0.000088 parts of vitamin Bs2With 0.000028 0.000088 parts of vitamin Bs6Sports food after the running being made through techniques such as dispensing, granulation, tablettings.Effervescent tablet uses integration of drinking and medicinal herbs food formula, comprehensive nutrition, comprehensive nutrition after running of the present invention, quickening exercise recovery is played, improvement qi-blood-body fluid is lost, qi depression to blood stasis, the function such as stable trophic nerve system, and be easy to carry, it is in good taste, it is edible suitable for sport people after running.
Description
Technical field
It is more particularly to a kind of to be suitable to the edible effervescent tablet of sport people and its preparation after running the present invention relates to field of food
Method.
Background technology
Effervescent tablet be it is a kind of it is popular can supplement the nutrients, dissolution time is short, unique flavor, portable leisure food
Product, are loved by people.In recent years, with China's economic high speed development, running body-building motion rapid rising, sport nutrition is gradually
The popular visual field is come into, the requirement to effervescent tablet also develops towards the direction that can improve uncomfortable diseases after motion.It is well known that motion
The phenomenons such as the DOMS, electrolyte imbalance, the qi-blood-body fluid loss that produce afterwards, result in the generation of sports fatigue, so as to influence
The daily life of sport people.Domestic sport nutrition brand is positioned in single unclear, effect, modern science and tradition at present
Cure the effervescent tablet products market shortage that Chinese medicine is combined.With the increase of running crowd's market capacity, develop a with traditional Chinese and western medicine
Effervescent tablet is extremely urgent after the running of characteristic.
The content of the invention
The shortage and deficiency of effervescent tablet after running in order to overcome the existing market combination of Chinese tradiational and Western medicine, and there is provided a kind of nutrition
Comprehensively, quickening exercise recovery is played, improvement qi-blood-body fluid is lost, qi depression to blood stasis, the function such as stable trophic nerve system, and be easy to
Carrying, in good taste, the effervescent tablet eaten suitable for sport people after running.
Another object of the present invention is to provide the preparation method of effervescent tablet after above-mentioned running.
The purpose of the present invention is achieved through the following technical solutions：1-8 parts of Fructus Rubi extract, 1-8 parts of white fungus
Extract, 1-12 parts of haw thorn extract, 20-45 parts of citric acid, 15-40 parts of sodium acid carbonate, 0.5-4 parts of phosphatidyl silk
Propylhomoserin, 0.5-4 parts of alkalization cocoa power, 1-8 parts of saleratus, 20-45 parts of sugar alcohol, 0.5-3 parts of magnesium stearates,
0.000028-0.000088 parts of vitamin Bs2With 0.000028-0.000088 parts of vitamin Bs6。
It is preferred that, it is characterised in that mainly it is made up of the raw material of following proportioning：3-5 parts of Fructus Rubi extract, 3-5 parts
Dried tremella extract, 4-8 parts of haw thorn extract, 30-35 parts of citric acid, 20-30 parts of sodium acid carbonate, 1-2 parts of phosphatidyl
Serine, 1-2 parts of alkalization cocoa power, 2-5 parts of saleratus, 30-35 parts of sugar alcohol, 0.5-2 parts of magnesium stearates,
0.00005-0.000088 parts of vitamin Bs2With 0.00005-0.000088 parts of vitamin Bs6。
Described sugar alcohol is：It is one or more in mannitol, xylitol, D-sorbite, maltitol.
Described various extracts be by water or 10-95% ethanol be solvent extraction, be concentrated and dried gained carry
Take thing.
The preparation method of described effervescent tablet, it is characterised in that：
（1）Weighing is got the raw materials ready：Sugar alcohol crosses 80 mesh sieves respectively, and each raw material is weighed by weight：Fructus Rubi extract, white fungus are extracted
Thing, haw thorn extract, citric acid, sodium acid carbonate, phosphatidylserine, alkalization cocoa power, saleratus, sugar alcohol, magnesium stearate,
Vitamin B2 and vitamin B6, are well mixed, standby；
（2）Dry：By step（1）Gained mixed material is uniformly spread out in stainless steel drip pan and is put into baking oven, control temperature 40-70
DEG C, time 1-5 hour；
（3）By step（2）Resulting material is put into dry granulating machine, and particle is made；
（4）It is total mixed：By step（3）Gained dry particl adds vitamin B2, vitamin B620-30min, shape are always mixed with magnesium stearate
Into semi-finished product；
（5）Tabletting：Semi-finished product are inputted into tabletting machine, effervescent tablet is made,.
The main component effect of effervescent tablet of the present invention is as follows：
Fructus Rubi extract：Supplementing the kidney to control the nocturnal, nourish the liver to improve visual acuity；
Dried tremella extract：Tonifying spleen appetizing, supplementing qi and nourishing yin, clearing heat and moistening dryness, improve immunity, antifatigue；
Haw thorn extract：Food digesting stomach fortifying, scattered stasis；
Three shares, the effect of nourishing yin to moisten dryness, tonifying spleen and stomach, liver and kidney benefiting, scattered stasis are played altogether；
Sodium citrate, citric acid, sodium acid carbonate, saleratus-removing lactic acid, remove free radical, supplement electrolyte；
Phosphatidylserine, alkalization cocoa power, vitamin B2, vitamin B6：Nutrient stabilizing nervous system；
Sugar alcohol：Energy is supplemented, water activity is reduced, product micro-organisms are controlled, beneficial to the stabilization of product；
Fructus Rubi extract, haw thorn extract, alkalization cocoa power：There is the strong local flavor of cocoa in mouthfeel, basin is covered while having
Son and the mixing fruity of hawthorn, product obtain mouthfeel lifting.
In summary, the present invention is main realizes that nourishing yin to moisten dryness, tonifying spleen and stomach, liver and kidney benefiting, promoting the circulation of qi dissipate using integration of drinking and medicinal herbs raw material
The effect of the stasis of blood.Utilize phosphatidylserine, alkalization cocoa power, vitamin B2, vitamin B6Collocation, for after running plant god
Through system dysfunction, play a part of nutrient stabilizing nervous system.Utilize sodium citrate, citric acid, sodium acid carbonate, carbonic acid
Hydrogen potassium after running for the problems such as lactic acid, free radical accumulation, electrolyte imbalance, playing removing lactic acid, free radical and supplement electrolysis
The effect of matter.
From the analysis of above-mentioned primary raw material and its trophic function, the invention has the advantages that：After the present invention is for running
The problems such as organism fatigue, lactic acid accumulation, gas the moon consumption wound, qi depression to blood stasis, electrolyte imbalance, automatic nervous system dysfunction, root
According to the Physiology and biochemistry after race, nutritional need, using Chinese medical discrimination, prescription opinion control, using integration of drinking and medicinal herbs raw material realize nourishing yin to moisten dryness,
While tonifying spleen and stomach, liver and kidney benefiting, scattered stasis effect, supplement the nutrients and energy, targetedly solve the above mentioned problem after running,
The recovery of post exercise organism fatigue is met, and products taste is good, steady quality is easy to carry, and is very suitable for supplementing after running
Energy, the sport people for alleviating sports fatigue is eaten.
Embodiment
The present invention is further described below by specific embodiment.
Embodiment 1：The raw material composition of effervescent tablet is after running：
4g Fructus Rubi extracts, 4g dried tremella extract, 6g haw thorn extract, 30g citric acid, 25g sodium acid carbonate, 2
G phosphatidylserine, 1g alkalization cocoa power, 4g saleratus, 35g xylitol, 1.5g magnesium stearates, 0.08mg dimensions
Raw element B2With 0.08mg vitamin Bs6。
Specifically preparation method is：
（1）Weighing is got the raw materials ready：Sugar alcohol crosses 80 mesh sieves respectively, and each raw material is weighed by weight：Fructus Rubi extract, white fungus are extracted
Thing, haw thorn extract, citric acid, sodium acid carbonate, phosphatidylserine, alkalization cocoa power, saleratus, sugar alcohol, magnesium stearate,
Vitamin B2 and vitamin B6, are well mixed, standby；
（2）Dry：By step（1）Gained mixed material is uniformly spread out in stainless steel drip pan and is put into baking oven, controls 40 DEG C of temperature, when
Between 5 hours；
（3）By step（2）Resulting material is put into dry granulating machine, and particle is made；
（4）It is total mixed：By step（3）Gained dry particl adds vitamin B2, vitamin B620min is always mixed with magnesium stearate, is formed
Semi-finished product；
（5）Tabletting：Semi-finished product are inputted into tabletting machine, effervescent tablet is made,.
Embodiment 2：The raw material composition of effervescent tablet is after running：
1g Fructus Rubi extracts, 1g dried tremella extract, 1g haw thorn extract, 20g citric acid, 15g sodium acid carbonate,
0.5g phosphatidylserine, 0.5g alkalization cocoa power, 0.5g saleratus, 20g maltitol, 0.5g stearic acid
Magnesium, 0.028mg vitamin Bs2With 0.028mg vitamin Bs6。
Specifically preparation method is：
（1）Weighing is got the raw materials ready：Sugar alcohol crosses 80 mesh sieves respectively, and each raw material is weighed by weight：Fructus Rubi extract, white fungus are extracted
Thing, haw thorn extract, citric acid, sodium acid carbonate, phosphatidylserine, alkalization cocoa power, saleratus, sugar alcohol, magnesium stearate,
Vitamin B2And vitamin B6, it is well mixed, it is standby；
（2）Dry：By step（1）Gained mixed material is uniformly spread out in stainless steel drip pan and is put into baking oven, controls temperature 50 C, when
Between 4 hours；
（3）By step（2）Resulting material is put into dry granulating machine, and particle is made；
（4）It is total mixed：By step（3）Gained dry particl adds vitamin B2, vitamin B625min is always mixed with magnesium stearate, is formed
Semi-finished product；
（5）Tabletting：Semi-finished product are inputted into tabletting machine, effervescent tablet is made,.
Embodiment 3：The raw material composition of effervescent tablet is after running：
8g Fructus Rubi extracts, 8g dried tremella extract, 12g haw thorn extract, 45g citric acid, 40g sodium acid carbonate,
4g phosphatidylserine, 4g alkalization cocoa power, 8g saleratus, 45g D-sorbite, 3g magnesium stearates, 0.088mg
Vitamin B2With 0.088mg vitamin Bs6。
Specifically preparation method is：
（1）Weighing is got the raw materials ready：Sugar alcohol crosses 80 mesh sieves respectively, and each raw material is weighed by weight：Fructus Rubi extract, white fungus are extracted
Thing, haw thorn extract, citric acid, sodium acid carbonate, phosphatidylserine, alkalization cocoa power, saleratus, sugar alcohol, magnesium stearate,
Vitamin B2 and vitamin B6, are well mixed, standby；
（2）Dry：By step（1）Gained mixed material is uniformly spread out in stainless steel drip pan and is put into baking oven, controls temperature 60 C, when
Between 3 hours；
（3）By step（2）Resulting material is put into dry granulating machine, and particle is made；
（4）It is total mixed：By step（3）Gained dry particl adds vitamin B2, vitamin B630min is always mixed with magnesium stearate, is formed
Semi-finished product；
（5）Tabletting：Semi-finished product are inputted into tabletting machine, effervescent tablet is made,.
Embodiment 4：The raw material composition of effervescent tablet is after running：
3g Fructus Rubi extracts, 6g dried tremella extract, 4g haw thorn extract, 35g citric acid, 20g sodium acid carbonate, 1g
Phosphatidylserine, 2g alkalization cocoa power, 6g saleratus, 15g mannitol, 20g D-sorbites, 1g stearic acid
Magnesium, 0.05mg vitamin Bs2With 0.07mg vitamin Bs6。
Specifically preparation method is：
（1）Weighing is got the raw materials ready：Sugar alcohol crosses 80 mesh sieves respectively, and each raw material is weighed by weight：Fructus Rubi extract, white fungus are extracted
Thing, haw thorn extract, citric acid, sodium acid carbonate, phosphatidylserine, alkalization cocoa power, saleratus, sugar alcohol, magnesium stearate,
Vitamin B2 and vitamin B6, are well mixed, standby；
（2）Dry：By step（1）Gained mixed material is uniformly spread out in stainless steel drip pan and is put into baking oven, controls temperature 70 C, when
Between 2.5 hours；
（3）By step（2）Resulting material is put into dry granulating machine, and particle is made；
（4）It is total mixed：By step（3）Gained dry particl adds vitamin B2, vitamin B626min is always mixed with magnesium stearate, is formed
Semi-finished product；
（5）Tabletting：Semi-finished product are inputted into tabletting machine, effervescent tablet is made,.
Embodiment 5：The raw material composition of effervescent tablet is after running：
6g Fructus Rubi extracts, 3g dried tremella extract, 8g haw thorn extract, 25g citric acid, 30g sodium acid carbonate, 3g
Phosphatidylserine, 3g alkalization cocoa power, 2g saleratus, 20g xylitol, 18g maltitols, 2g stearic acid
Magnesium, 0.07mg vitamin Bs2With 0.05mg vitamin Bs6。
Specific preparation method be the same as Example 1.
The water activity of the product of test example 1
Effervescent tablet is made in embodiment 1 ~ 5 and commercial samples 1#, 2# respectively take 5,25 DEG C of temperature, the phase of humidity 30 ~ 50% is placed on
Lower 2 hours with environment, its average moisture activity value is determined using LabSwift-aw water activities analyzer respectively.Experiment condition is such as
Under：Standard Calibration Solutions are saturation potassium chloride, and measurement temperature is 25 DEG C, and time of measuring is 5min, as a result as shown in table 1 below：
Table 1
This experimental result shows, the sample water activity value that embodiment 1 ~ 5 makes is and commercial samples between 0.589-0.592
1#, 2# water activity average value are 0.651 and 0.655 or so.Most of water activity caused needed for putrefactive microorganisms growth
Value is more than 0.6, therefore, and the water activity for the sample that embodiment 1 ~ 5 makes is less than 0.6, that is, is not suitable for the life of putrefactive microorganisms
It is long, it is not susceptible to putrid and deteriorated.
The estimation of stability of test example 2
Effervescent tablet and commercial samples 1#, 2# is made at 35 ~ 39 DEG C of temperature, the identical environment of humidity 70 ~ 80% in embodiment 1 ~ 5,
Carry out trimestral shelf-life experiment, its sense organ of periodic monitor and physics and chemistry, the Qualification of microbiological indicator.As a result such as table 2 below
It is shown：
Table 2
Contrast finds that the effervescent tablet of the present embodiment has the longer shelf-life.
The mouthfeel evaluation of test example 3
Using effervescent tablet made from embodiment 1 ~ 5 with containing the commercially available effervescent tablet of component portion identical as sample 3# and sample 4#,
7 kinds of samples are eaten to 100 experimental subjects and effervescent tablet mouthfeel is evaluated, it is as a result as shown in table 3 below：
Table 3
The result of table 3 shows that the effervescent tablet of the present embodiment has more preferably mouthfeel.
The anti-fatigue effect evaluation of test example 4
Using effervescent tablet made from embodiment 1 ~ 2 with containing the commercially available effervescent tablet of component portion identical as sample 3# and sample 4#,
125 experimental subjects are arranged to be divided into 5 groups, effervescent tablet sample 20g made from first group of edible embodiment 1, second group eats
Effervescent tablet sample 20g made from embodiment 3, the 3rd group of edible sample 3#20g, the 4th group of edible sample 4#20g, the 5th group is owned
Object eats 20g D-sorbites as blank control group, and each group objects starts to run in same starting point after 30min, records respectively
Every experimental subjects starts to produce the time and continuous running time of hunger；
Table 4
The result of table 4 shows that the effervescent tablet of the present embodiment can substantially postpone hunger, and extension is run the duration, with obvious
Antifatigue effect.
The neural nutrition protective effect of 5 pairs of test example
1. tire mouse cortical neuron culture
Pregnant 17-19 d SD tire mouse are taken, after 75% alcohol belly routine disinfection, taking-up tire mouse of cutting open the belly is rapidly separated tire mouse skin
Matter is put in dissection liquid, rejects pia mater and blood vessel, the cortex tissue isolated is placed in the plate for filling dissection liquid, with eye
Section is cut into about 300~500um brain piece, through final concentration of 0.125% Trypsin Induced 30min (37 DEG C), terminates digestion
Screen filtration collects filtrate afterwards, and adjustment cell quantity is about 1*109Then/L, 4 % trypan blue microscopy survival rates ＞ 90%. will
Cell suspension inoculation is to (96 orifice plates are inoculated with 100 μ l, and 6 orifice plates are inoculated with 2 ml) in the culture plate being coated with poly-D-lysine.37
℃、5% CO224 h are cultivated in incubator after the complete culture solution that equivalent is mended after cell attachment, hereafter 1 culture are changed every 2-3 d
Liquid.Culture 6-7d neuronal cell is used to test.
Model is prepared and experiment packet
Culture 7d cortical neurons (96 orifice plate) are taken, are washed 2 times with sugar-free Earle ' s liquid, are added simultaneously containing even two per hole
Sugar-free Earle ' s liquid 100 μ the l of sodium sulfite (2 mmol/ L), 37 DEG C, be incubated after 3h in 5% CO2 incubators and take out, then
Change normal nutrient solution into and continue to be put into incubator and be incubated 20h, as hypoxia-reoxygenation model.Experiment packet：1. blank control
Group：Original fluid is sucked, is washed with sugar-free Earle ' s liquid after 2 times, is still incubated with normal complete medium, not anoxic；2. mould
Type control group：Washed 2 times with sugar-free Earle ' s liquid, add the μ l of sugar-free Earle ' s liquid 100 of the sodium dithionite containing 2mmol/L,
37 DEG C, be incubated after 3h in 5% CO2 incubators and take out, then change normal nutrient solution into and continue to be put into incubator and be incubated 20h；3. originally
5 groups described in embodiment 1 ~ 5：Each group is dissolved in 100ml pure water with 1, and 2h adds each group solution and is incubated before modeling；4. it is commercially available
Two groups of effervescent tablet：Sample 3# and sample 4#, 3. processing method is same to be carried out, and 2h adds solution and is incubated before same modeling.96 orifice plates are trained
Support neuronal cell.Add 20 μ l MTT solution (gL-1 of final concentration 0.5) incubator lucifuges to be incubated 4 h per hole after modeling, add thin
Cellular lysate liquid acts on 24 h, and with the absorbance (A values) that each hole is determined at ELIASA, 550 nm, A values are in positive with cytoactive
Close, and calculate survival rate（%）：Survival rate（%）=（Absorbance-model absorbance is administered）/（Blank control absorbance-model extinction
Degree）×100%.
Experimental result is as shown in table 5：
5 pairs of table lacks the influence (x ± s) of sugared anoxic cortical neurons activity
Note：Compared with blank control group, # P<0.01；Compared with model control group, * P<0.05; ** P<0.01；Assuming that empty
White control group is 100%.
As seen from the above table, cell recovers after 20h processing, MTT results (A values) are substantially reduced through lacking sugared anoxic 3h（With blank
Control group compares P<0.01）.Compared with model group, 1 ~ 5 group of the present embodiment can raise cell A values（Compared P with model group<
0.01）, its relative survival rate is compared with model group significant difference.As a result show to lure lacking sugared anoxic product of the present invention
That leads cortical neuron damage has nutrition protective effect.
Test example 6 influences to evaluate on blood lactase acid level
Wistar male rats are randomly divided into 6 groups, every group 10 by body weight and sex.Wherein 4 groups：Embodiment 1 prepares sample
Product, embodiment 4 prepare sample, commercial samples 1#, commercial samples 2#, and each group is dissolved in 100ml pure water with 1, obtains solution；
5th group：Physiological saline group.Foregoing 5 groups carry out gavage, totally 30 days by 2.5ml once a day.It is remaining one group（Blank group）Do not locate
Reason.Each group weight ratio is compared with there was no significant difference (q inspections).In addition to blank group, a swimming exercise is carried out within every 10 days, respectively
Rat was allowed after gavage respectively in the 10th day, 20 days and the 30th day in (28 ± 2 DEG C), depth of water 60cm water went swimming 120min, each mouse
Tail blood is adopted respectively 1 time, Serum lactic acid content is determined with acetaldehyde-parazon method.Lactate level is averaged after three motions of calculating
Value, observes influence of the effervescent tablet of the present invention to lactate level value after rat motor.As a result 6 be see the table below：
Table 6
Note：# is compared with blank group, there is significant difference（P ＜ 0.05）；
* compared with physiological saline group, there is significant difference（P ＜ 0.05）.
Compared with blank group lactic acid average value, physiological saline group has significant difference（P ＜ 0.05）.With physiological saline group breast
Sour average value compares, and there was no significant difference for sample 1# and sample 2# groups（P ＞ 0.05）.Embodiment 1 and 4 groups have conspicuousness poor
It is different.As a result show, effervescent tablet of the invention can substantially reduce the blood lactase acid level after rat motor.
Influence evaluation of the test example 6 to blood coagulation
Kunming mice is randomly divided into 6 groups, every group 10 by body weight and sex.Wherein, there are 4 groups：Embodiment 1 prepare sample,
Embodiment 3 prepares sample, commercial samples 1#, commercial samples 2#, and each group is dissolved in 100ml pure water with 1, obtains solution.5th
Group：Physiological saline group.Foregoing 5 groups carry out gavage, continuous 10 days by 0.3ml once a day.Another group（Blank group）Do not handle.
Each group weight ratio is compared with there was no significant difference (q inspections).In addition to blank group, each group animal carries out a swimming exercise in every 2 days,
Respectively at the 2nd, mouse is allowed respectively in (28 ± 2 DEG C), depth of water 30cm water went swimming 50min, each mouse after gavage within 4,8 and the 10th days
Tail blood is adopted respectively 1 time, then by ACL-200 (U.S.'s Beckman) type Intelligent blood agglutination meter detection measurement prothrombin time
And active partial thromboplastin time (PT)（APTT）, the average value of 4 testing results is calculated, 7 are as a result see the table below：
Table 7
Note：* compared with physiological saline group, there is significant difference（P ＜ 0.05）；
Compared with blank group, there was no significant difference for physiological saline group（P ＞ 0.05）.
Compared with physiological saline group PT, there was no significant difference for sample 1# and sample 2# groups（P ＞ 0.05）.Embodiment 1 and 3 groups
There is significant difference.Compared with physiological saline group APTT, there was no significant difference for sample 1# and sample 2# groups（P ＞ 0.05）.It is real
Applying example 1 and 3 groups has significant difference.As a result show, effervescent tablet of the invention can be obviously prolonged the PT after mouse movement and
APTT, also shows that effervescent tablet of the present invention has sanguimotor effect after the motion that has some improvement.
Claims (5)
- Effervescent tablet after 1. one kind is run, it is characterised in that be mainly made up of the raw material of following proportioning：1-8 parts of raspberry is extracted Thing, 1-8 parts of dried tremella extract, 1-12 parts of haw thorn extract, 20-45 parts of citric acid, 15-40 parts of sodium acid carbonate, 0.5-4 parts of phosphatidylserine, 0.5-4 parts of alkalization cocoa power, 1-8 parts of saleratus, 20-45 parts of sugar alcohol, 0.5-3 Part magnesium stearate, 0.000028-0.000088 parts of vitamin Bs2With 0.000028-0.000088 parts of vitamin Bs6。
- 2. application as claimed in claim 1, it is characterised in that be mainly made up of the raw material of following proportioning：3-5 parts of raspberry Extract, 3-5 parts of dried tremella extract, 4-8 parts of haw thorn extract, 30-35 parts of citric acid, 20-30 parts of sodium acid carbonate, 1-2 parts of phosphatidylserine, 1-2 parts alkalization cocoa power, 2-5 part of saleratus, 30-35 parts of sugar alcohol, 0.5-2 parts firmly Fatty acid magnesium, 0.00005-0.000088 part vitamin B2With 0.00005-0.000088 parts of vitamin Bs6。
- 3. application as claimed in claim 1 or 2, it is characterised in that described sugar alcohol is：Mannitol, xylitol, sorbose It is one or more in alcohol, maltitol.
- 4. energy stick as claimed in claim 1 or 2, it is characterised in that described various extracts are by water or 10- 95% ethanol is solvent extraction, is concentrated and dried the extract of gained.
- 5. a kind of preparation method of effervescent tablet as described in claim 1, it is characterised in that：（1）Weighing is got the raw materials ready：Sugar alcohol crosses 80 mesh sieves, and each raw material is weighed by weight：Fructus Rubi extract, dried tremella extract, mountain Short, bristly hair or beard extract, citric acid, sodium acid carbonate, phosphatidylserine, alkalization cocoa power, saleratus, sugar alcohol, magnesium stearate, dimension life Plain B2 and vitamin B6, are well mixed, standby；（2）Dry：By step（1）Gained mixed material is uniformly spread out in stainless steel drip pan and is put into baking oven, control temperature 40-70 DEG C, time 1-5 hour；（3）By step（2）Resulting material is put into dry granulating machine, and particle is made；（4）It is total mixed：By step（3）Gained dry particl adds vitamin B2, vitamin B620-30min, shape are always mixed with magnesium stearate Into semi-finished product；（5）Tabletting：Semi-finished product are inputted into tabletting machine, effervescent tablet is made,.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109527325A (en) * | 2018-11-20 | 2019-03-29 | 江苏汉典生物科技股份有限公司 | A kind of sports type effervescent tablet and preparation method thereof |
| CN113040309A (en) * | 2021-03-26 | 2021-06-29 | 烟台金利昌食品有限公司 | Bottled nutrient soda solid beverage and processing technology thereof |
| EP3868367A4 (en) * | 2018-10-17 | 2022-06-29 | Byhealth Co., Ltd. | Micro-effervescent buccal tablet and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569198A (en) * | 2004-05-08 | 2005-01-26 | 郭东宇 | Effervesce tablet of ginseng |
| CN1631247A (en) * | 2005-01-20 | 2005-06-29 | 北京科信必成医药科技发展有限公司 | Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof |
-
2016
- 2016-03-02 CN CN201610115916.0A patent/CN107149077A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569198A (en) * | 2004-05-08 | 2005-01-26 | 郭东宇 | Effervesce tablet of ginseng |
| CN1631247A (en) * | 2005-01-20 | 2005-06-29 | 北京科信必成医药科技发展有限公司 | Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof |
Cited By (4)
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| EP3868367A4 (en) * | 2018-10-17 | 2022-06-29 | Byhealth Co., Ltd. | Micro-effervescent buccal tablet and preparation method thereof |
| US12220481B2 (en) | 2018-10-17 | 2025-02-11 | BYHEALTH Co., Ltd. | Buccal micro-effervescent tablet and preparation method thereof |
| CN109527325A (en) * | 2018-11-20 | 2019-03-29 | 江苏汉典生物科技股份有限公司 | A kind of sports type effervescent tablet and preparation method thereof |
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