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CN107136062B - Mixture prepared by blending agricultural synergist, bifenazate and etoxazole compound and preparation and application thereof - Google Patents

Mixture prepared by blending agricultural synergist, bifenazate and etoxazole compound and preparation and application thereof Download PDF

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Publication number
CN107136062B
CN107136062B CN201710457200.3A CN201710457200A CN107136062B CN 107136062 B CN107136062 B CN 107136062B CN 201710457200 A CN201710457200 A CN 201710457200A CN 107136062 B CN107136062 B CN 107136062B
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bifenazate
etoxazole
compound
agricultural
synergist
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CN107136062A (en
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郭正
汤晓燕
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Guilin Jiqi Biochemistry Co ltd
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Guilin Jiqi Biochemistry Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a mixture prepared by mixing an agricultural synergist, bifenazate and etoxazole compounds, and a preparation method and application thereof, wherein in the mixture, the agricultural synergist is N-380, the bifenazate and etoxazole compounds are acaricides, the weight ratio of the agricultural synergist to the acaricides is 1:0.5-30, and the weight ratio of the bifenazate to the etoxazole compounds is 1: 8-50. The invention also relates to the use of said agricultural synergist for increasing the penetration of the acaricide through the body surface of the harmful mites, and to the use of said mixture for controlling agricultural harmful mites.

Description

Mixture prepared by blending agricultural synergist, bifenazate and etoxazole compound and preparation and application thereof
Technical Field
The invention relates to the field of agriculture, in particular to a mixture prepared by mixing an agricultural synergist with bifenazate and etoxazole compounds, and preparation and application thereof.
Background
China is a big agricultural country, and the use of pesticides cannot be avoided in actual agricultural production, but with the influence of factors such as the prolonging of chemical control pesticide application history of agricultural pests, unscientific use of pesticides and the like, the resistance of the agricultural pests is increasingly serious, the types of the pests generating the resistance are continuously increased, and the agricultural pest control pesticide is one of the agricultural problems which are urgently needed to be solved at present.
Bifenazate (bifenazate) is a bifenazate acaricide, is a white solid in pure products, is a novel acaricide for selective foliar spray, belongs to a non-systemic acaricide, is effective to each life stage of mites, has ovicidal activity and knockdown activity to adult mites, has little influence on predatory mites, and is very suitable for comprehensive control of pests.
Etoxazole (etoxazole) is an acaricide developed by Sumitomo chemical corporation in Japan, belongs to a diphenyl oxazoline derivative, mainly has the effects of contact poisoning and stomach poisoning, basically has no systemic property, can prevent and treat eggs, young mites, nymphs and the like, and is effective on tetranychus urticae koch, panonychus ulmi, tetranychus urticae koch, tetranychus cinnabarinus and the like of crops such as oranges, apples, vegetables, flowers and the like.
Chinese patent CN101999382A discloses an acaricidal composition containing etoxazole and bifenazate, which can be prepared into water dispersible granules, suspending agents, wettable powder, dispersible oil suspending agents, missible oil, aqueous emulsion or microemulsion formulations, and has good control effect on red spiders of oranges, apple trees and cotton.
Chinese patent CN104054732A discloses an agricultural acaricide water suspension agent composition, which specifically comprises etoxazole and bifenazate and can effectively improve the control effect on spider mites.
Chinese patent CN105613542A discloses a synergistic acaricidal composition containing etoxazole and bifenazate, the dosage forms are suspending agent, aqueous emulsion, microemulsion, water dispersible granule, wettable powder, ultra-low volume liquid, microcapsule suspending agent and the like, the synergistic acaricidal composition has the advantages of synergistic effect, small usage amount and low cost, and is used for preventing and treating panonychus ulmi, tetranychus urticae koch, tetranychus cinnabarinus and the like of field crops, fruits, vegetables and the like.
Although the prior art discloses a compound of bifenazate and etoxazole, the research in this respect only stays at the synergistic level, that is, the toxicity or control effect of the composition is determined by indoor or field experiments relative to a single dose, and no further research or improvement is carried out, and the prior art does not pay attention to or pay attention to the effective utilization rate of the medicament after application, such as the amount of medicament penetrating the body surface of pest mites, which causes unnecessary waste.
N-380 is a commercially available polyoxyethylene ether modified trisiloxane substance, is a novel functional auxiliary agent, is known to have good wetting property, and can effectively inhibit foam generation in pesticide preparation processing.
Disclosure of Invention
Based on the problems in the prior art, the inventor finally screens out an agricultural synergist which can effectively increase the penetration of pesticides such as bifenazate, etoxazole and the like on the surface of the acarid through long-term research on pesticide preparations, acarid surface physiology and the like, and the theoretical expectation is exceeded. Based on this finding, the inventors have completed the present invention.
The invention aims to provide a mixture prepared by mixing an agricultural synergist with bifenazate and etoxazole compounds, and preparation and application thereof.
The invention is realized by the following technical scheme.
A mixture prepared by mixing an agricultural synergist with a bifenazate and etoxazole compound, wherein the agricultural synergist is N-380; the bifenazate and etoxazole compound is an acaricide.
Wherein N-380 is a compound of polyoxyethylene ether modified trisiloxane compounds which accord with the following structure:
Figure 536831DEST_PATH_IMAGE002
wherein n =14-16, and the molar ratio M of the threen14:Mn15:Mn16=1-2:1-2:1-2。
In the mixture of the invention, the weight ratio of the agricultural synergist to the acaricide is 1:0.5-30, preferably 1:1-25, more preferably 1: 5-9.
In the mixture of the invention, the weight ratio of bifenazate to etoxazole is 1:8 to 50, preferably 1:12 to 24, more preferably 1: 15.
The mixture according to the invention, wherein the mixture further comprises agriculturally acceptable carriers and/or adjuvants, is prepared into agriculturally acceptable dosage forms, preferably into aqueous emulsions, microemulsions, emulsifiable concentrates, wettable powders, water dispersible granules, suspensions.
The dosage forms are conventional in the art, and the preparation method is well known to those skilled in the art, and the adjuvants and/or carriers and the amounts thereof used for preparing the above dosage forms are also well known to those skilled in the art, for example, refer to "agricultural formulation processing technology". The pesticidally acceptable carriers and adjuvants used include, but are not limited to: solvents, emulsifiers, dispersants, wetting agents, binders, disintegrants, thickeners, antifreeze agents, stabilizers, preservatives, fillers and/or carriers, and the like. One skilled in the art may select one or more of the adjuvants and/or carriers.
In one embodiment of the invention, the mixture of the invention is prepared as a suspension formulation consisting of: 1-50% of acaricide compound, 1-25% of N-3800.1, 1-25% of dispersant, 1-25% of wetting agent, 0.1-5% of thickening agent, 0.5-5% of antifreeze agent, 0.1-5% of defoaming agent, 0-5% of preservative and water which are complemented to 100%. The preparation method comprises the following steps: mixing the effective components and various assistants with water, and performing high-speed shearing dispersion and sanding by a sand mill to form a high-dispersion stable suspension system to prepare the suspending agent.
In one embodiment of the invention, the mixture of the invention is prepared as a wettable powder having a formulation consisting of: 1-50% of acaricide compound, 1-25% of N-3800.1, 1-25% of dispersant, 1-25% of wetting agent and solid carrier, wherein the solid carrier is complemented to 100%. The preparation method comprises the following steps: the components are mixed, ground and crushed to prepare the wettable powder.
In one embodiment of the invention, the mixture of the invention is prepared as an aqueous emulsion having the formula composition: 1-50% of acaricide compound, 1-40% of N-3800.1-10%, 1-40% of solvent, 1-25% of emulsifier, 1-25% of dispersant, 0.5-5% of thickener, 0.5-5% of defoamer, 0.5-5% of antifreeze, 0-5% of stabilizer and water which are complemented to 100%. The preparation method comprises the following steps: dissolving the acaricide compound with a solvent to prepare an oil phase, adding other components into water, uniformly stirring to prepare a water phase, then adding the oil phase into the water phase while stirring, and uniformly stirring to prepare the aqueous emulsion.
In one embodiment of the invention, the mixture of the invention is prepared into water dispersible granules, and the formula composition of the water dispersible granules is as follows: 1-50% of acaricide compound, 1-25% of N-3800.1, 1-25% of dispersant, 1-25% of wetting agent, 1-10% of disintegrant, 0.1-5% of binder and the balance of solid carrier to 100%. The preparation method comprises the following steps: the components are uniformly mixed, and are crushed and granulated to prepare the water dispersible granule.
Wherein, in the formula, the solvent can be selected from: one or more of methanol, ethanol, isopropanol, benzene, toluene, xylene, acetone, dimethylformamide, dimethyl sulfoxide, dichloromethane, cyclohexane, cyclohexanone, N-methylpyrrolidone, petroleum ether and ethyl acetate;
the emulsifier can be selected from: one or more of sodium lignosulfonate, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, calcium dodecyl benzene sulfonate, styryl phenyl polyoxyethylene ether, phenethyl phenol polyoxyethylene polyoxypropylene ether, fatty alcohol polyoxyethylene ether, nonylphenol polyoxyethylene ether phosphate, castor oil polyoxyethylene ether phosphate, phenyl phenol polyoxyethylene ether phosphate, naphthalene sulfonate formaldehyde condensate, benzyl dimethyl phenol polyoxyethylene ether, sorbitan monostearate polyoxyethylene ether and sorbitan fatty acid ester polyoxyethylene ether;
the dispersing agent can be selected from: one or more of alkylphenol phosphate sodium salt, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether formaldehyde condensate, glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, sodium lignosulfonate, fatty alcohol polyoxyethylene ether sulfate, fatty alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether, polyoxyethylene lanolin alcohol and polyoxyethylene sorbitan fatty acid ester;
the wetting agent can be selected from: one or more of di-sec-octyl maleate sodium sulfonate, N-lauroyl sodium glutamate, sodium dodecyl sulfate, triphenyl ethylphenol polyoxyethylene ether, calcium dodecyl benzene sulfonate, isooctyl sodium succinate, sodium lauroyl sarcosinate, castor oil polyoxyethylene ether and fatty alcohol polyoxyethylene ether;
the adhesive can be selected from: one or more of gelatin, acacia, xanthan gum, starch, carboxymethyl cellulose and carboxyethyl cellulose;
the disintegrating agent can be selected from: one or more of sodium sulfate, calcium sulfate, sodium bicarbonate, ammonium sulfate and magnesium chloride;
the thickening agent can be selected from: one or more of polyvinyl acetate, magnesium aluminum silicate, Arabic gum, xanthan gum, gelatin and polyvinyl alcohol;
the defoaming agent can be selected from: : one or more of polydimethylsiloxane, butyl phosphate, isobutyl phosphate, n-octanol, silicone, and the like;
the antifreezing agent can be selected from: one or more selected from ethylene glycol, propylene glycol, glycerol, etc.;
the stabilizing agent can be selected from: one or more of triphenyl phosphite, N-soybean oil-based trimethylene diamine, dialkyl succinate sulfonate, epichlorohydrin, butyl glycidyl ether and the like;
the preservative can be selected from: one or two of sodium benzoate and benzoic acid;
the filler and/or carrier includes a solid filler and/or carrier and a liquid filler and/or carrier. Wherein, the solid filler and/or the carrier can be selected from: one or more of diatomite, kaolin, attapulgite, white carbon black, bentonite, montmorillonite and calcium carbonate. The liquid filler and/or carrier may be selected from one or more of water, castor oil, soybean oil, mineral oil.
Another aspect of the invention relates to the use of an agricultural synergist for increasing penetration of an acaricide through the body surface of a pest mite, wherein the agricultural synergist is N-380; the acaricide is a compound of bifenazate and etoxazole.
Wherein the weight ratio of the agricultural synergist to the acaricide is 1:0.5-30, preferably 1:1-25, more preferably 1: 5-9.
The weight ratio of the bifenazate to the etoxazole is 1:8-50, preferably 1:12-24, and more preferably 1: 15.
The harmful mites are plant harmful mites, such as eggs, larvae, nymphs, adults and the like, and specifically comprise Tetranychus urticae ((II) ((III)Tetranychusurticae) Tetranychus citriodorus (I) and (II)Panonychuscitri) Coffee mites (A. Megae)Oligonychuscoffee) Cotton spider mite (A)Tetranychustelarius) And acarus precalcinosus (apple acarus)Aculusschlechtendali) Panonychus ulmi (apple mites)Panonychusulmi) Tetranychus urticae kochPanonychusulmi) And Tetranychus cinnabarinus (Tetranychus cinnabarinus). Preferred is Tetranychus citriodorus (A)Panonychuscitri) And Tetranychus pomonella (C.) (Panonychusulmi). More preferably Tetranychus citrinopileatus (A)Panonychuscitri)。
Another aspect of the invention relates to the use of the mixtures according to the invention for controlling agricultural mites. Wherein the harmful mites are plant harmful mites, such as eggs, larvae, nymphs, adults and the like, and specifically comprise Tetranychus urticae (A)Tetranychusurticae) Tetranychus citriodorus (I) and (II)Panonychuscitri) Coffee mites (A. Megae)Oligonychuscoffee) Cotton spider mite (A)Tetranychustelarius) And acarus precalcinosus (apple acarus)Aculusschlechtendali) Panonychus ulmi (apple mites)Panonychusulmi) Tetranychus urticae kochPanonychusulmi) And Tetranychus cinnabarinus (Tetranychus cinnabarinus). Preferred is Tetranychus citriodorus (A)Panonychuscitri) And Tetranychus pomonella (C.) (Panonychusulmi). More preferably Tetranychus citrinopileatus (A)Panonychuscitri)。
The application rates of the mixtures according to the invention (converted to acaricide formulations) are, for example, from 0.1 to 1000g ai/ha, preferably from 1 to 200g ai/ha.
The various starting materials and/or reagents used in the present application are commercially available. For example, the acaricide and various auxiliary agents and carriers can be easily purchased from the market; the synergist N-380 is also commercially available, and may be obtained, for example, from Nonong Beijing International Biotechnology Ltd.
All% referred to herein are "weight percent" unless otherwise indicated.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to limit the invention to these embodiments. It will be appreciated by those skilled in the art that the present invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.
N-380 used in the following examples was purchased from International Biotechnology Ltd, Beijing, Nono, and molar ratio Mn14:Mn15:Mn16=1:2:1。
All% references are to "percent by weight" unless otherwise indicated.
Preparation examples
Formulation example 1 aqueous emulsion
1% of bifenazate, 8% of etoxazole, N-3801%, 10% of ethyl acetate, 6% of sodium dodecyl sulfate, 2% of fatty alcohol-polyoxyethylene ether phosphate, 1% of Arabic gum, 0.5% of butyl phosphate, 4% of ethylene glycol and the balance of water to 100%.
The preparation method comprises the following steps: the components are mixed with water, and a high-dispersion and stable suspension system is formed after high-speed shearing dispersion and sanding of a sand mill, so that the suspending agent is prepared.
Formulation example 2 aqueous emulsion
0.5% of bifenazate, 10% of etoxazole, N-3800.5%, 12% of ethyl acetate, 5% of calcium dodecyl benzene sulfonate, 4% of glycerol fatty acid polyoxyethylene ether, 1% of polyvinyl acetate, 0.5% of isobutyl phosphate, 5% of propylene glycol and the balance of water to 100%.
The preparation method comprises the following steps: the components are mixed with water, and a high-dispersion and stable suspension system is formed after high-speed shearing dispersion and sanding of a sand mill, so that the suspending agent is prepared.
Formulation example 3 suspending agent
1% of bifenazate, 24% of etoxazole, N-3801.67%, 8% of polyoxyethylene sorbitan fatty acid ester, 4% of N-lauroyl sodium glutamate, 1% of magnesium aluminum silicate, 3% of glycol, 0.5% of silicone, 0.5% of sodium benzoate and water in balance to 100%.
The preparation method comprises the following steps: the components are mixed with water, and a high-dispersion and stable suspension system is formed after high-speed shearing dispersion and sanding of a sand mill, so that the suspending agent is prepared.
Formulation example 4 Water dispersible granule
1% of bifenazate, 15% of etoxazole, N-3802%, 6% of sodium naphthalene sulfonate formaldehyde condensate, 4% of sodium di-sec-octyl maleate sulfonate, 4% of calcium sulfate, 4% of Arabic gum and the balance of diatomite to 100%.
The preparation method comprises the following steps: the components are uniformly mixed, and are crushed and granulated to prepare the water dispersible granule.
Formulation example 5 Water dispersible granule
1.5% of bifenazate, 18.5% of etoxazole, N-3804%, 5% of nonylphenol polyoxyethylene ether, 5% of isooctyl ester sodium succinate, 5% of ammonium sulfate, 5% of carboxyethyl cellulose and the balance of bentonite to 100%.
The preparation method comprises the following steps: the components are uniformly mixed, and are crushed and granulated to prepare the water dispersible granule.
Formulation example 6 wettable powder
1% of bifenazate, 32% of etoxazole, N-3802.1%, 8% of polyoxyethylene lanolin alcohol, 3% of sodium lauroyl sarcosinate and diatomite which are complemented to 100%.
The preparation method comprises the following steps: the components are mixed, ground and crushed to prepare the wettable powder.
Formulation example 7 wettable powder
2% of bifenazate, 30% of etoxazole, N-3804%, 6% of fatty alcohol-polyoxyethylene ether phosphate, 6% of isooctanol succinate sodium sulfonate and kaolin, wherein the balance is up to 100%.
The preparation method comprises the following steps: the components are mixed, ground and crushed to prepare the wettable powder.
(II) penetration test of body surface of harmful mite
1. Tetranychus citriodorus test
For testing harmful mites: tetranychus citriodorus (A) and (B)Panonychuscitri)
Test and control agents: bifenazate and etoxazole; cyflumetofen
Test synergist and control adjuvant: n-380; NF-100 (glycosyl modified organic silicon assistant) and penetrating agent T
The test method comprises the following steps:
ethyl acetate is used for preparing mother liquor of bifenazate and etoxazole compound (bifenazate: etoxazole =1: 15) with the total concentration of 5000mg/L and cyflumetofen mother liquor with the concentration of 5000mg/L for later use.
Respectively weighing a certain amount of synergist N-380, a contrast aid NF-100 and a penetrating agent T, preparing solutions with the concentration of 50 mg/L by using distilled water respectively, and dividing into a plurality of parts. According to the experimental design shown in the following table 1, a certain amount of pre-prepared mother solution of the miticide is added to the prepared solution to a concentration of 400 mg/L. The weight ratio of the acaricide to the synergist in each solution is 8: 1.
Selecting citrus leaf mite nymphs with consistent sizes. Taking a plurality of finger tubes, placing 100 nymphs in each finger tube, then adding 5ml of each prepared treatment solution, fixing the finger tubes on a shaking table, and keeping the finger tubes to shake gently. After 1 hour, the solution in the vial was poured off and the surface of the nymph mites was washed 3 times with ethyl acetate to wash the remaining agent on the surface of the nymph mites.
Adopting an improved QuEChERS extraction method, mashing nymphae of a cleaned epidermal medicament, putting the smashed nymphae into a centrifugal tube, adding 2ml of ethyl acetate, uniformly swirling for 2 minutes, and standing for 10 minutes; then centrifuging for 10 minutes at 3000 revolutions per minute, taking supernatant, adding the supernatant into a centrifuge tube containing anhydrous sodium sulfate and ethylenediamine-N-Propylsilane (PSA), uniformly swirling for 10 seconds, centrifuging for 10 minutes at 3000 revolutions per minute, filtering by a filter membrane, concentrating the supernatant to be nearly dry, fixing the volume by using 1ml of ethyl acetate, and detecting the pesticide content in the sample by using GC. Each treatment was repeated 3 times. The results are shown in Table 1 below.
TABLE 1 permeation amounts of the respective treatment agents
Figure 80070DEST_PATH_IMAGE004
The result shows that the synergist N-380 can obviously increase the amount of the bifenazate and etoxazole compound penetrating through the body surface of harmful mites, and the penetration amount is 4.21 mu g and is far greater than that of the compound added with NF-100 and the penetrating agent T. However, the penetration effect of the synergist N-380 to the control agent cyflumetofen was not significantly increased compared to the case of adding NF-100 and the penetrant T.
2. Tetranychus apple test
The mites to be tested are tetranychus pomonensis (A)Panonychusulmi)
The remaining test methods were the same as for Tetranychus citriodorus. The results are shown in Table 2 below.
TABLE 2 permeation amounts of the respective treatment agents
Figure 46758DEST_PATH_IMAGE006
The result shows that the synergist N-380 can obviously increase the amount of the bifenazate and etoxazole compound penetrating through the body surface of harmful mites, and the penetration amount is 3.95 mug and is far greater than that of the compound added with NF-100 and the penetrating agent T. However, the penetration effect of the synergist N-380 to the control agent cyflumetofen was not significantly increased compared to the case of adding NF-100 and the penetrant T.
The above examples are merely illustrative and not restrictive of the present invention, and the solution obtained by simple modification of the above solution is also within the scope of the present application.

Claims (3)

1. A mixture mixed by an agricultural synergist, bifenazate and etoxazole compound, which is characterized in that,
the agricultural synergist is N-380, and the N-380 is a compound of polyoxyethylene ether modified trisiloxane compounds which accord with the following structure:
Figure 955227DEST_PATH_IMAGE001
wherein n =14-16, and the molar ratio M of the threen14:Mn15:Mn16=1:2:1；
The bifenazate and etoxazole compound is an acaricide;
the weight ratio of the agricultural synergist to the acaricide is 1: 5-9;
the weight ratio of the bifenazate to the etoxazole is 1: 15.
2. An application of agricultural synergist for increasing penetration of acaricide through the body surface of harmful mites is characterized in that,
the agricultural synergist is N-380, and the N-380 is a compound of polyoxyethylene ether modified trisiloxane compounds which accord with the following structure:
Figure 97495DEST_PATH_IMAGE001
wherein n =14-16, and the molar ratio M of the threen14:Mn15:Mn16=1:2:1；
The acaricide is a compound of bifenazate and etoxazole;
the weight ratio of the agricultural synergist to the acaricide is 1: 5-9;
the weight ratio of the bifenazate to the etoxazole is 1: 15.
3. Use of the mixture of claim 1 for controlling agricultural mites.
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Denomination of invention: A mixture of agricultural synergist mixed with biphenylhydrazide ester and imidacloprid complex and its preparation and application

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