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CN107126907A - Pharmaceutical synthesis device - Google Patents

Pharmaceutical synthesis device Download PDF

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Publication number
CN107126907A
CN107126907A CN201610109944.1A CN201610109944A CN107126907A CN 107126907 A CN107126907 A CN 107126907A CN 201610109944 A CN201610109944 A CN 201610109944A CN 107126907 A CN107126907 A CN 107126907A
Authority
CN
China
Prior art keywords
plemum
negative pressure
pressure chamber
pharmaceutical synthesis
synthesis device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610109944.1A
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Chinese (zh)
Inventor
刘渊豪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuboron Medtech Ltd
Original Assignee
Neuboron Medtech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuboron Medtech Ltd filed Critical Neuboron Medtech Ltd
Priority to CN201610109944.1A priority Critical patent/CN107126907A/en
Publication of CN107126907A publication Critical patent/CN107126907A/en
Pending legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/04Pressure vessels, e.g. autoclaves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/56Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21FPROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F7/00Shielded cells or rooms

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)

Abstract

The present invention provides a kind of pharmaceutical synthesis device, including plemum and negative pressure chamber, wherein there is the first air pressure of superatmospheric in plemum, negative pressure chamber has the second air pressure less than the first air pressure, negative pressure chamber, which not only acts as, prevents the impurity outside pharmaceutical synthesis device from entering in pharmaceutical synthesis environment, in the pressure official post pharmaceutical synthesis environment of the first air pressure in the second air pressure and plemum in negative pressure chamber and neighbouring impurity is moved to the direction away from pharmaceutical synthesis environment, the pharmaceutical synthesis environment of plemum composition has further been purified;Filter on plemum and negative pressure chamber can filter the gas for discharging the pharmaceutical synthesis device, not only inhibit and environment is caused harm outside drug diffusion to pharmaceutical synthesis device, and the medicine of filtering can be utilized with secondary recovery.

Description

Pharmaceutical synthesis device
Technical field
The present invention relates to a kind of pharmaceutical synthesis device, especially a kind of pharmaceutical synthesis device with cleaning function.
Background technology
If drug quality will be had a strong impact on and not reach medicine quality standard by being mixed into impurity during pharmaceutical synthesis, medicine is also wrapped Radiopharmaceutical is included, in radiopharmaceutical building-up process, radioactive ray will endanger environment or the health of operating personnel, be Solve contaminated problem and to prevent the harm of radiopharmaceutical during pharmaceutical synthesis, conventional method is in closed tool at present There is the building-up process that medicine is completed in the environment of certain cleannes.
Generally there is the opening portion for being put into raw material or taking out medicine there is provided the obturator of the closed environment, closed in medicine Outside impurity can be entered in the closed environment by opening portion and the gap of obturator during, so that synthesis can be polluted Medicine;Likewise, medicine/radioactive substance/impurity can ooze out the closed environment, one by the gap of opening portion and obturator Aspect can cause the loss of medicine, and the medicine/radioactive substance on the other hand oozed out may endanger environment or the health of operating personnel, The foreign matter oozed out may influence the cleannes of environment, at present it is not yet found that for improving pharmaceutical synthesis cleannes and preventing medicine The technology leaked to beyond pharmaceutical synthesis room.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical synthesis device, the pharmaceutical synthesis device is on the one hand by suppressing pharmaceutical synthesis Impurity outside device enters in the pharmaceutical synthesis device to effectively improve the cleannes of synthetic drug;On the other hand effectively suppression Pharmacy thing is spread out from pharmaceutical synthesis device, can not only reduce the loss of medicine, be also prevented from the medicine that spreads out/ Radioactive material confrontation environment and operating personnel cause harm.
To achieve these goals, the invention provides a kind of pharmaceutical synthesis device, the pharmaceutical synthesis device include plemum and Negative pressure chamber, wherein plemum are to be provided with the first opening in the casing being made up of the wall being connected with each other, the face wall of the plemum Portion, the pharmaceutical synthesis component being internally provided with for synthesizing and accommodating medicine of the plemum, the inside of the plemum has First air pressure of superatmospheric;Negative pressure chamber is located at the outside of plemum, and at least covers the first opening portion, the negative pressure chamber Gas in interior the second air pressure having less than the first air pressure, plemum enters negative pressure chamber by pressure differential.
Wherein, pharmaceutical synthesis process occurs in the plemum, and plemum has the first air pressure of superatmospheric, therefore can Entered with suppressing the impurity outside the pharmaceutical synthesis device in plemum, so as to avoid pollution of the impurity to medicine;It is described negative Pressure chamber at least covers the first opening portion, can directly be contacted between the first opening portion and face wall relative to the impurity in external environment condition Gap and be possible to be directly entered in plemum, negative pressure chamber on the one hand play a part of stop impurity the first barrier, the opposing party Face, can be by controlling the second air pressure in negative pressure chamber to increase the pressure differential between the first air pressure and the second air pressure, to increase seam Impurity present in gap enters the pressure of negative pressure chamber, so as to be contaminated during further avoiding pharmaceutical synthesis.Negative pressure Room except can only cover the first opening portion and prevent impurity from the gap between the first opening portion and face wall enter malleation room in addition to, Those skilled in the art know ground, and negative pressure chamber is set by such:On the one hand it can avoid the impurity in plemum being diffused into outside Portion's environment;On the other hand avoid the impurity of external environment condition penetrating into plemum.Therefore, negative pressure chamber is also used as a connection Structure covering plemum other apertured places, it might even be possible to the need for practical application, negative pressure chamber surround entirely it is whole just Pressure chamber.
Further, a separate space for being adjacent to the face wall, plemum are provided between the plemum and negative pressure chamber Interior gas is entered in negative pressure chamber by the separate space.
The separate space has further stops that pharmaceutical synthesis device foreign matter enters institute after negative pressure chamber is as the first barrier It can be the first air pressure to state the air pressure in the effect of the second barrier of plemum, the separate space, or higher than the second gas Pressure but the 3rd air pressure for being less than the first air pressure, are entered in plemum it is possible thereby to suppress extraneous impurity by pressure differential, so as to keep away Exempt to be contaminated during pharmaceutical synthesis.The separate space sets the in negative pressure chamber and the wall parallel with the face wall Two opening portions, second opening portion be able to can also not only make for being put into raw material to plemum or taking out medicine from plemum The gas of the plemum inflow separate space is according to separate space and the pressure differential of negative pressure chamber is by the second opening portion and is adjacent Wall between gap flow into negative pressure chamber.
Further, in the pharmaceutical synthesis device, the plemum has exhaust outlet, for discharging the gas in plemum, Equipment useful life is reduced to avoid malleation room pressure excessive, it is necessary to which what is illustrated is, although plemum has exhaust outlet, but It is to still need to be maintained above the first air pressure of atmospheric pressure in plemum.
Preferably, in the pharmaceutical synthesis device, the plemum has:
Booster mechanism, for increasing the pressure inside plemum;With
First filter, the gas of plemum is injected for purifying booster mechanism.
Wherein booster mechanism has the effect for the first air pressure for making the plemum be maintained above atmospheric pressure, in order to avoid pharmaceutical synthesis During medicine by by booster mechanism inject plemum gaseous contamination, needed before gas is injected into plemum by the first mistake Filter removes after impurity reaches certain clean rank and reinjects plemum.
Preferably, in the pharmaceutical synthesis device, limited valve and the second filter are connected on the exhaust outlet of the plemum, Pressure limiting valve is used to control the pressure in plemum, while the first air pressure superatmospheric in plemum is maintained, reduction by first Infringement of the air pressure to plemum structure;And the second filter be used for be filtered through pressure limiting valve discharge gas, it is to avoid drug particles from The exhaust outlet discharge medicine synthesizer and pollute environment or operating personnel caused harm, and the second filter is filtered down Medicine can be continued with by processing physically or chemically, reduce medicine loss.
Preferably, in the pharmaceutical synthesis device, the 3rd mistake that the negative pressure chamber has the mechanism of decompressor and is connected with the mechanism of decompressor Filter, the mechanism of decompressor includes gas pressure reducer, aspiration pump or the air blower of exhaust, the second air pressure to make negative pressure chamber Less than the first air pressure in plemum, the 3rd filter is used for the gas for being filtered through mechanism of decompressor discharge.
The 3rd filter being connected in negative pressure chamber with the mechanism of decompressor can filter the medicine penetrated into negative pressure chamber, prevent medicine from leaking to Outside pharmaceutical synthesis device, and the 3rd filter filtering under drug particles medicine can be reduced by secondary recovery It is lost in, reduces and waste.
Wherein it is preferred that in the pharmaceutical synthesis device, the second air pressure subatmospheric, when the second air pressure is higher than first Gas in negative pressure chamber can be made during air pressure to pharmaceutical synthesis device flows outside, it is to avoid impurity enters plemum by negative pressure chamber; When the second air pressure is less than the first air pressure, the pressure differential of plemum and negative pressure chamber becomes big, can preferably suppress impurity and enter from negative pressure chamber Enter malleation chamber contamination medicine.
Preferably, in the pharmaceutical synthesis device, the exhaust outlet of the plemum is connected with negative pressure chamber, makes plemum and negative pressure Room shares a mechanism of decompressor, the gas in plemum is discharged into negative pressure chamber.Gas in plemum is respectively through position Filtered for the first time in the first filter of plemum exhaust ports and make row by second of filtering positioned at the filter of negative pressure chamber second The gas for going out medicine synthesizer is purer, improves the secondary recovery degree of medicine.
Preferably, in the pharmaceutical synthesis device, the exhaust outlet of the plemum is located at outside negative pressure chamber, makes plemum with bearing Pressure chamber is provided with the separate mechanism of decompressor, respectively to emit the gas in plemum and negative pressure chamber.Independent row Gas approach and the mechanism of decompressor can be such that the maintenance of the pharmaceutical synthesis device more facilitates.
Preferably, in the pharmaceutical synthesis device, constitute the interconnection wall of the plemum include face wall, back face wall, Left side wall, right side wall, roof and bottom wall, wherein face wall and back face wall respectively with roof, right side wall, bottom wall and left side wall phase Even;The wall of all interconnections for constituting the plemum of negative pressure chamber's covering.Those skilled in the art know ground, negative pressure chamber At least two walls in above-mentioned six wall can also only be covered.
When negative pressure chamber covers the wall of all interconnections for constituting the plemum, the pressure in plemum can be avoided to be less than Or during equal to atmospheric pressure, impurity outside pharmaceutical synthesis device enters plemum and dirty from the gap between the wall of the interconnection The medicine in plemum is contaminated, plays a part of further purifying.
Preferably, in the pharmaceutical synthesis device, the wall of the plemum or the negative pressure chamber is constituted by radioactivity can be suppressed The radioactive ray shielding material composition that ray is penetrated.Except needing to suppress radiopharmaceutical by filter during synthesis of radiopharmaceuticals Grain ooze out outside pharmaceutical synthesis device, in addition it is also necessary to suppress the radiopharmaceutical in plemum ray penetrate pharmaceutical synthesis device wall and Surrounding environment is caused harm, and the wall that plemum or negative pressure chamber are made of radioactive ray shielding material can effectively solve radioactivity and penetrate The problem of line is revealed.
The present invention realizes the effect of purification drug synthetic environment by the pressure differential in plemum and negative pressure chamber room, and by dividing Do not set filter to realize the secondary recovery of drug particles at the exhaust outlet of plemum and the pressure-reducing valve of negative pressure chamber, prevent medicine Thing or radioactive substance leakage cause that the loss of medicine can also be reduced while environmental pollution.The technical scheme that the present invention is provided can be with It is effective the problem of solve medicine leakage and drug contamination easily occur during pharmaceutical synthesis in the prior art.
Brief description of the drawings
Fig. 1 is the side cross sectional views of pharmaceutical synthesis device.
Fig. 2 is the front cross-sectional schematic diagram of pharmaceutical synthesis device.
Embodiment
The present invention is further described below in conjunction with the accompanying drawings, it will be appreciated that discussed below only illustrative, and it is unrestricted Property.
As depicted in figs. 1 and 2, the pharmaceutical synthesis device include plemum 100, negative pressure chamber 200 and positioned at plemum and Separate space 300 in the middle of negative pressure chamber, plemum 100 is the casing being made up of the wall 120 being connected with each other, to be used as medicine The space of synthesis, these be connected with each other walls 120 be respectively face wall 155, back face wall 157, left side wall 154, right side wall 152, There is the first opening portion 156 on roof 151 and bottom wall 153, wherein face wall 155.The box house can be as needed by saturating The material of gas separates into different spaces can be arranged as required to medicine to make full use of in the casing synthetic drug, each space Thing synthesizes environment of the component 130 to provide pharmaceutical synthesis.There is the first air pressure of superatmospheric in plemum 100, in order to The air pressure in plemum 100 is maintained, in the technical scheme of the present embodiment, plemum has the filtering of booster mechanism 111 and first Device 112, wherein booster mechanism 111 to the plemum 100 to be pressurizeed to maintain superatmospheric in plemum 100 The first air pressure, the first filter 112 be used for filter booster mechanism 111 injection plemum 100 in gas, to maintain malleation Clean rank in room 100.Corresponding with booster mechanism 111, plemum also has on exhaust outlet 140, exhaust outlet 140 and had The filter 142 of pressure limiting valve 141 and second, wherein, the position of the filter 142 of pressure limiting valve 141 and second can be answered according to actual With being exchanged.The effect of exhaust outlet 140 is to make to maintain certain pressure in plemum by pressure limiting valve 141, when plemum 100 When interior pressure is excessive, the pressure limiting valve 141 on exhaust outlet 140 can be with discharge unit gas, to improve the use of pharmaceutical synthesis device The second filter 142 on time limit, exhaust outlet 140 has the effect for collecting the medicine in the gas that pressure limiting valve 141 is discharged, one Aspect prevents medicine 130 from leaking to the pollution to environment in the environment outside pharmaceutical synthesis device, on the other hand, the second filter 142 medicines filtered down can prevent the loss of medicine by secondary recovery.In addition, by plemum face wall 155 First opening portion 156 can be put into the raw material of synthetic drug into plemum 100 or the medicine synthesized is taken out out of plemum. Impurity outside plemum 100 by the gap between the opening portion 156 of plemum face wall 155 and first and may be constituted just Gap between the wall 120 of the interconnection of pressure chamber enters plemum, but plemum has the first air pressure higher than external pressure, Therefore, even if the impurity that plemum has outside gap as described above, plemum also will not enter plemum by the gap Interior pollution pharmaceutical synthesis environment.
The gap between wall 120 in order to prevent interconnection that impurity passes through plemum enters in plemum 100, the present embodiment Negative pressure chamber 200 not only covers the first opening portion 156, and encloses whole plemum 100, that is to say, that negative pressure chamber 200 is covered Six walls 120 for constituting plemum 100 are built;Can be first right before negative pressure chamber 200 uses as the barrier of plemum 100 Negative pressure chamber 200 is purified, and removes wherein impurity, when the impurity concentration in negative pressure chamber 200 is less than the concentration of external environment condition impurity When, negative pressure chamber 200 serves the effect of the barrier of the purification internal environment of plemum 100 first;Negative pressure chamber 200 has negative booster The filter 212 of structure 211 and the 3rd, the need for the position of the filter 212 of the mechanism of decompressor 211 and the 3rd can be according to practical application Changed, wherein the mechanism of decompressor 211 is used to make the second air pressure in negative pressure chamber less than the first air pressure in plemum, it is preferable that The mechanism of decompressor 211 makes the second air pressure subatmospheric to increase the pressure differential between plemum 100 and negative pressure chamber 200, so that more The good impurity that avoids is entered in plemum 100 by above-mentioned gap.The wall for constituting the connected space of negative pressure chamber 200 can be independent Wall beyond plemum and separate space, directly can also be used as one of negative pressure locular wall by the use of plemum and the wall of separate space Point.In addition, the separate space 300 in the middle of plemum and negative pressure chamber functions similarly to the effect of the barrier of negative pressure chamber.
The exhaust outlet 140 of plemum is connected with negative pressure chamber 200 in the technical scheme of the present embodiment, from the row of plemum exhaust outlet 140 The gas gone out can pass through the 3rd filter 212 being connected in negative pressure chamber with the mechanism of decompressor 211 and filter again, further avoid Medicine in plemum is with air-flow discharge medicine synthesizer.The exhaust outlet 140 of plemum can also be according to the need of practical application It is arranged on the outside of negative pressure chamber 200 (omitting diagram).
During pharmaceutical synthesis device synthesis of radiopharmaceuticals, except needing to filter radiopharmaceutical particles by three filters to avoid Radiopharmaceutical is diffused into air to cause harm outside to environment, in addition it is also necessary to be used as plemum, independent sky with radioactive ray shielding material Between or negative pressure chamber wall, to avoid radioactive ray from being caused harm through pharmaceutical synthesis device to environment or operating personnel.
The present invention by provide one have the first air pressure plemum and its air pressure inside can be manipulated so that its air pressure inside is low Come to provide a cleaner environment for pharmaceutical synthesis in the negative pressure chamber of the first air pressure, and by being located at plemum and negative pressure respectively Medicine in the gas of three filters filtering discharge on room, in order to avoid the environment outside drug contamination pharmaceutical synthesis device.
The pharmaceutical synthesis device that the present invention is disclosed is not limited to the structure represented by content and accompanying drawing described in above example. Apparently change, replacement or the modification made on the basis of the present invention to the material of wherein component, shape and position, All within the scope of protection of present invention.

Claims (10)

1. a kind of pharmaceutical synthesis device, it is characterised in that:The pharmaceutical synthesis device includes plemum and negative pressure chamber, and wherein plemum is Be provided with the first opening portion in the casing being made up of the wall being connected with each other, the face wall of the plemum, the plemum it is interior Portion is provided with the pharmaceutical synthesis component for synthesizing and accommodating medicine, and the inside of the plemum has the first of superatmospheric Air pressure;Negative pressure chamber is located at the outside of plemum, and at least covers in the first opening portion, the negative pressure chamber with less than first Gas in second air pressure of air pressure, plemum enters negative pressure chamber by pressure differential.
2. pharmaceutical synthesis device as claimed in claim 1 a, it is characterised in that neighbour is provided between the plemum and negative pressure chamber The gas in the separate space of the face wall, plemum is connected to by the separate space to enter in negative pressure chamber.
3. pharmaceutical synthesis device as claimed in claim 1, it is characterised in that the plemum has exhaust outlet, for discharging malleation Indoor gas.
4. the pharmaceutical synthesis device as described in any one of claims 1 to 3, it is characterised in that the plemum has:
Booster mechanism, for increasing the pressure inside plemum;With
First filter, the gas of plemum is injected for purifying booster mechanism.
5. pharmaceutical synthesis device as claimed in claim 3, it is characterised in that connected on the exhaust outlet of the plemum limited valve and Second filter, pressure limiting valve is used to control the pressure in plemum, and the second filter is used for the gas for being filtered through pressure limiting valve discharge Body.
6. the pharmaceutical synthesis device as described in any one of claims 1 to 3, it is characterised in that the negative pressure chamber have the mechanism of decompressor and The 3rd filter being connected with the mechanism of decompressor, the mechanism of decompressor includes gas pressure reducer, aspiration pump or the air blower of exhaust, The second air pressure to make negative pressure chamber is less than the first air pressure in plemum, and the 3rd filter is used to be filtered through mechanism of decompressor row The gas gone out.
7. pharmaceutical synthesis device as claimed in claim 3, it is characterised in that the exhaust outlet of the plemum is connected with negative pressure chamber, is made Plemum shares a mechanism of decompressor with negative pressure chamber, the gas in plemum is discharged into negative pressure chamber.
8. pharmaceutical synthesis device as claimed in claim 3, it is characterised in that the exhaust outlet of the plemum is located at outside negative pressure chamber, Make plemum that negative pressure chamber to be provided with the separate mechanism of decompressor, respectively to discharge the gas in plemum and negative pressure chamber Go out.
9. pharmaceutical synthesis device as claimed in claim 1, it is characterised in that constituting the interconnection wall of the plemum includes front Wall, back face wall, left side wall, right side wall, roof and bottom wall, wherein face wall and back face wall respectively with roof, right side wall, Bottom wall is connected with left side wall;The wall of all interconnections for constituting the plemum of negative pressure chamber's covering.
10. pharmaceutical synthesis device as claimed in claim 1, it is characterised in that constitute the plemum or the wall of the negative pressure chamber The radioactive ray shielding material penetrated by that can suppress radioactive ray is constituted.
CN201610109944.1A 2016-02-26 2016-02-26 Pharmaceutical synthesis device Pending CN107126907A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610109944.1A CN107126907A (en) 2016-02-26 2016-02-26 Pharmaceutical synthesis device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610109944.1A CN107126907A (en) 2016-02-26 2016-02-26 Pharmaceutical synthesis device

Publications (1)

Publication Number Publication Date
CN107126907A true CN107126907A (en) 2017-09-05

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CN201610109944.1A Pending CN107126907A (en) 2016-02-26 2016-02-26 Pharmaceutical synthesis device

Country Status (1)

Country Link
CN (1) CN107126907A (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549512A (en) * 1994-11-30 1996-08-27 Lucent Technologies Inc. Minienvironment for hazardous process tools
JP2000320872A (en) * 1999-05-13 2000-11-24 Nikka Micron Kk Clean room
CN1640509A (en) * 2004-01-15 2005-07-20 中国人民解放军63971部队 Comprehensive protection system for infectious disease specimen pathological dissection room
CN101804958A (en) * 2010-04-29 2010-08-18 浙江卫信生物药业有限公司 Sterile negative pressure isolation facility of capping machine
CN103295658A (en) * 2012-02-22 2013-09-11 住友重机械工业株式会社 Hot cell
CN103436443A (en) * 2013-09-05 2013-12-11 天津开发区合普工贸有限公司 Integrated zero-leakage gas positive-negative pressure compatible microorganism isolation operation cabinet
CN104930633A (en) * 2015-06-23 2015-09-23 苏州达善净化科技有限公司 Inner-negative-pressure air supply method and cleaning device with method
CN205462125U (en) * 2016-02-26 2016-08-17 南京中硼联康医疗科技有限公司 Drug synthesis device
JP2018095298A (en) * 2016-12-15 2018-06-21 三菱重工機械システム株式会社 Beverage filling apparatus

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549512A (en) * 1994-11-30 1996-08-27 Lucent Technologies Inc. Minienvironment for hazardous process tools
JP2000320872A (en) * 1999-05-13 2000-11-24 Nikka Micron Kk Clean room
CN1640509A (en) * 2004-01-15 2005-07-20 中国人民解放军63971部队 Comprehensive protection system for infectious disease specimen pathological dissection room
CN101804958A (en) * 2010-04-29 2010-08-18 浙江卫信生物药业有限公司 Sterile negative pressure isolation facility of capping machine
CN103295658A (en) * 2012-02-22 2013-09-11 住友重机械工业株式会社 Hot cell
CN103436443A (en) * 2013-09-05 2013-12-11 天津开发区合普工贸有限公司 Integrated zero-leakage gas positive-negative pressure compatible microorganism isolation operation cabinet
CN104930633A (en) * 2015-06-23 2015-09-23 苏州达善净化科技有限公司 Inner-negative-pressure air supply method and cleaning device with method
CN205462125U (en) * 2016-02-26 2016-08-17 南京中硼联康医疗科技有限公司 Drug synthesis device
JP2018095298A (en) * 2016-12-15 2018-06-21 三菱重工機械システム株式会社 Beverage filling apparatus

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Application publication date: 20170905

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