CN107115555A - A kind of compound dressing of efficient liquid-absorbent hemostatic and preparation method thereof - Google Patents
A kind of compound dressing of efficient liquid-absorbent hemostatic and preparation method thereof Download PDFInfo
- Publication number
- CN107115555A CN107115555A CN201710296109.8A CN201710296109A CN107115555A CN 107115555 A CN107115555 A CN 107115555A CN 201710296109 A CN201710296109 A CN 201710296109A CN 107115555 A CN107115555 A CN 107115555A
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- China
- Prior art keywords
- sodium
- regenerated cellulose
- parts
- preparation
- solution
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 32
- 239000002250 absorbent Substances 0.000 title claims abstract description 27
- 239000004627 regenerated cellulose Substances 0.000 claims abstract description 94
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 53
- 229920000615 alginic acid Polymers 0.000 claims abstract description 53
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 35
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 35
- 239000011734 sodium Substances 0.000 claims abstract description 35
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 35
- 239000000835 fiber Substances 0.000 claims abstract description 34
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 32
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 27
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 27
- 238000005516 engineering process Methods 0.000 claims abstract description 24
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940072056 alginate Drugs 0.000 claims abstract description 22
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 16
- 238000012545 processing Methods 0.000 claims abstract description 15
- 239000000243 solution Substances 0.000 claims description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 21
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 21
- 239000004332 silver Substances 0.000 claims description 21
- 229910052709 silver Inorganic materials 0.000 claims description 21
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 20
- 239000000661 sodium alginate Substances 0.000 claims description 20
- 235000010413 sodium alginate Nutrition 0.000 claims description 20
- 229940005550 sodium alginate Drugs 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 18
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims description 18
- 239000002671 adjuvant Substances 0.000 claims description 16
- 238000004140 cleaning Methods 0.000 claims description 16
- 239000012153 distilled water Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 12
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000002166 wet spinning Methods 0.000 claims description 11
- 238000001556 precipitation Methods 0.000 claims description 10
- 230000003647 oxidation Effects 0.000 claims description 9
- 238000007254 oxidation reaction Methods 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 238000009987 spinning Methods 0.000 claims description 9
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 238000001994 activation Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000005520 cutting process Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 7
- 230000008929 regeneration Effects 0.000 claims description 7
- 238000011069 regeneration method Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 230000003213 activating effect Effects 0.000 claims description 6
- 239000006227 byproduct Substances 0.000 claims description 6
- 230000008034 disappearance Effects 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 239000001632 sodium acetate Substances 0.000 claims description 6
- 235000017281 sodium acetate Nutrition 0.000 claims description 6
- 229960005137 succinic acid Drugs 0.000 claims description 6
- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- 239000011975 tartaric acid Substances 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 5
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000012498 ultrapure water Substances 0.000 claims description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 2
- AQLLBJAXUCIJSR-UHFFFAOYSA-N OC(=O)C[Na] Chemical compound OC(=O)C[Na] AQLLBJAXUCIJSR-UHFFFAOYSA-N 0.000 claims 1
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 description 16
- 229960001126 alginic acid Drugs 0.000 description 16
- 239000000783 alginic acid Substances 0.000 description 16
- 206010052428 Wound Diseases 0.000 description 14
- 150000004781 alginic acids Chemical class 0.000 description 11
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 8
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 8
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 8
- 229940105329 carboxymethylcellulose Drugs 0.000 description 8
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000004744 fabric Substances 0.000 description 7
- -1 anion polysaccharide Chemical class 0.000 description 6
- 239000002131 composite material Substances 0.000 description 6
- 238000007654 immersion Methods 0.000 description 6
- 230000000740 bleeding effect Effects 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 229910001961 silver nitrate Inorganic materials 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000000025 haemostatic effect Effects 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 239000012752 auxiliary agent Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000010148 water-pollination Effects 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
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- 108010010803 Gelatin Proteins 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000005213 imbibition Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
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- 239000000523 sample Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- AEMOLEFTQBMNLQ-BZINKQHNSA-N D-Guluronic Acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@H]1O AEMOLEFTQBMNLQ-BZINKQHNSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 238000004176 ammonification Methods 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002468 redox effect Effects 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
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- 239000012779 reinforcing material Substances 0.000 description 1
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- 238000004088 simulation Methods 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-N sodium;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O QGMRQYFBGABWDR-UHFFFAOYSA-N 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
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Classifications
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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Abstract
The present invention relates to medical supplies technical field, a kind of compound dressing of efficient liquid-absorbent hemostatic and preparation method thereof is disclosed.Described compound dressing is prepared by sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginate blended fiber through needle punched non-woven fabrics processing technology.It can significantly improve that alginates are hemostatic and absorbency the invention provides one kind, while improving alginates hygrometric state mechanical strength and assigning the compound dressing of the efficient liquid-absorbent hemostatic of its certain bacteriostasis property.
Description
Technical field
The present invention relates to medical supplies technical field, and in particular to the compound dressing and its system of a kind of efficient liquid-absorbent hemostatic
Preparation Method.
Background technology
When skin and mucosa injury suitable dressing should be selected to be covered on wound, it has holding wound moist environment, inhaled
Contracture secretion, pain of alleviation and the effect for controlling bleeding, so as to promote wound healing.There are some researches prove in wet environment
Under, speed of wound healing is twice under dryness environment so that people have new understanding to the process of wound healing.Due to pain
Pain is the symptom occurred with skin damage, and treatment of some wounds to pain is the factor that wound care mainly considers.
Therefore, the research and development of NEW TYPE OF COMPOSITE analgesia functional material are significant to nuring wound and remissive treatment pain, are that the surface of a wound is applied
Expect the new trend of development.
Alginic acid（alginic acid）, be a kind of anion polysaccharide widely distributed in brown alga cell membrane, by with water
Combine to form viscoloid.Alginic acid is the polysaccharide being made up of mannuronic acid and guluronic acid, has been used as Dressing substrate
Material decades.As dressing matrix, alginic acid is highly biocompatible, can absorb substantial amounts of wound fluid and form solidifying
Glue, the healing environment of one " moistening " is provided for wound healing, protects wound surface, reduces wound infection rate, promotes wound to be cured
Close, reduce the discomfort of patient during change dressings.These superior functions of alginic acid are its application band in terms of medical dressing
Wide prospect is carried out.
However, pure alginic acid based material there is wet strength and mechanical integrity is relatively low, compliance is poor and hemostatic
Can be limited the problem of.It is the common method for solving these problems that polymer, which is blended or is combined,.In the prior art, existing a large amount of passes
In alginates and the compound method to improve functional dressing performance of other biological functional material, chitosan, glue are mainly included
Former albumen, gelatin, polyvinyl alcohol, pectin, cellulose fibre, fibroin albumen, hyaluronic acid etc. are blended or composite modified carried
The performance of high alginic acid based material.But there is also some problems, such as glue for the above blending or composite modified material
There is immunity risk in the use of former albumen and gelatin；Although chitosan can significantly improve the antibiotic property of material, machinery is strong
Degree, anthemorrhagic performance improve limited；Polyvinyl alcohol can improve the mechanical strength of material, but to hemostatic, not significantly improve work
With.
The content of the invention
Undesirable the invention aims to solve existing alginate material haemostatic effect, structural intergrity, machinery are strong
Degree and the relatively low technical problem of stability can significantly improve that alginates are hemostatic and absorbency there is provided one kind, while improving algae
Hydrochlorate hygrometric state mechanical strength and assign its certain bacteriostasis property efficient liquid-absorbent hemostatic compound dressing.
To achieve these goals, the technical scheme that provides of the present invention is：
A kind of compound dressing of efficient liquid-absorbent hemostatic, by sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginic acid
Salt blend fiber is prepared through needle punched non-woven fabrics processing technology.
Further, described sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginate blended fiber is
Wet-spinning is passed through by the modified obtained modified oxidized regenerated cellulose of regenerated cellulose and sodium carboxymethylcellulose, sodium alginate
Silk technique is prepared.
Further, the modification procedure of described regenerated cellulose is：Regenerated cellulose and sodium metaperiodate are reacted, then
Reacted with glycol cleaning solution, the regenerated cellulose just aoxidized is then molten by the regenerated cellulose just aoxidized and silver-colored ammonia
Liquid reacts, you can obtain modified oxidized regenerated cellulose.
A kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic, its specific preparation process is as follows：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in the sodium metaperiodate aqueous solution, the pH value of solution is adjusted,
Excessive IO is removed in stirring, the glycol cleaning solution for being then placed in 0.05 ~ 0.1mol/L4 -, cleaned with high purity water, it is freeze-dried
The regenerated cellulose just aoxidized can be obtained；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In silver ammino solution, adjuvant is added, 40 ~ 60 DEG C are heated up to, until bubble-free is produced, after being rinsed with absolute ethyl alcohol, then
With high purity water by product cleaning to neutrality, finally 24 ~ 48h is dried in 30 ~ 45 DEG C of vacuum drying chambers, you can obtain modified oxidized regeneration
Cellulose；
（3）The preparation of compound dressing：Modified oxidized regenerated cellulose and sodium carboxymethylcellulose, sodium alginate powder are prepared
Into blend solution, the stirring at 30 ~ 50 DEG C obtains sodium carboxymethylcellulose/modified oxidized until well mixed, filtering, deaeration
Regenerated cellulose/sodium alginate co-blended spinning stoste；By spinning solution by entering spinning head after spinning pump, filter, from spray
Silk pore pressure goes out stoste thread, and stoste thread, which enters in coagulating bath, forms nascent blended fiber, then through drawing-off, washing, sub-wire, dry
After dry, rolling step, sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginate blended fiber is obtained, blending is fine
Non-woven fabric coiled material is made through needle punched non-woven fabrics processing technology in dimension, then compound dressing is made through cutting, packaging, sterilizing.
It is preferred that, described step（1）The mass percent of meso-periodic acid sodium water solution is 1 ~ 5%, described pH value for 2 ~
3, lucifuge persistently stirs 1 ~ 3h at 30 ~ 40 DEG C, and glycol cleaning solution is ethylene glycol, 1,3-PD or polyethylene glycol.
It is preferred that, described step（2）In go oil processing go fluid to be formulated by following components by weight percent：Sodium hydroxide
100 ~ 200 parts of 5 ~ 15 parts, 30 ~ 60 parts of sodium acetate, 30 ~ 60 parts of sodium carbonate and distilled water；The activating solution of activation process is by weight
Number meter, is dissolved in after 10 ~ 20 parts of water respectively by 0.2 ~ 2 part of silver nitrate, 0.1 ~ 1 part of EDTA, and mixing carries out reaction generation precipitation, then drips
Ammonification water is formulated to disappearance is precipitated.
It is preferred that, described step（2）In just oxidation oxidized regenerated cellulose and silver ammino solution in solute mol ratio
For 1：4~5.
It is preferred that, described step（2）Middle adjuvant is formulated by following components by weight percent：2 ~ 6 parts of tartaric acid, concentration are
95% 60 ~ 100 parts of 5 ~ 15 parts of ethanol, 5 ~ 10 parts of butanedioic acid, 0.002 part of thiocarbamide, 0.1 ~ 2 part of EDTA and distilled water, and auxiliary
Agent mixed liquor weight is the 10 ~ 20% of silver ammino solution.
It is preferred that, described step（3）In modified oxidized regenerated cellulose and sodium carboxymethylcellulose, sodium alginate powder
Mass ratio be 1 ~ 6：1~3：9.
A kind of compound dressing of efficient liquid-absorbent hemostatic of the present invention, by sodium metaperiodate on regenerated cellulose C2 and C3 positions
Secondary hydroxyl carried out the preliminary oxidation of selectivity, then further aoxidized by silver ammino solution so as to introducing dicarboxyl, a side
Face, assigns the oxidized regenerated cellulose preferable hydrophily, and the hydrophily makes the oxidized regenerated cellulose sodium be sent out with alginate
Raw molecular level is combined（Cross-linking process except participating in alginic acid, moreover it is possible to alginic acid strand formation semi-interpenetrating polymer network
Structure）, the structural intergrity, mechanical strength and stability of compound dressing are improved, common alginates non-woven fabrics is overcome and applies
Expect low, the yielding shortcoming of insufficient strength, mechanical integrity under hygrometric state；On the other hand, the silver with redox property is utilized
Mirror reaction, and adjuvant is introduced, its regenerated cellulose surface is realized chemical deposition, by the deposition of silver of reduction to regenerated cellulose
Surface, so as to assign dressing certain bacteria resistance function.
Beneficial effects of the present invention are：
（1）The oxidized regenerated cellulose that modified crosslinking is obtained due to containing double carboxyl structures, making its hydrophily significantly improve,
Therefore when being contacted with the bleeding surface of a wound, meet blood and expand and the moisture in blood can be absorbed rapidly, make pachyemia, viscosity increases
Greatly, velocity of blood flow slows down；Viscosity very strong colloid can be formed after dissolving, and then can well block and oppress capillary.
（2）In the modified oxidized regenerated cellulose sodium of the present invention/alginate hemostasis composite, contained by alginate
Ca2+Release, can promote the formation of thrombokinase, accelerate hemostasis process.Therefore, modified oxidized regenerated cellulose sodium/
The double-hemostasis function that alginate hemostasis composite has oxidized regenerated cellulose sodium and alginate is acted on, and makes bleeding stopping period big
It is big to shorten, reach the effect of quick-acting haemostatic powder, overcome that common alginates adhesive-bonded fabric dressing hemostatic mechanism is single, anthemorrhagic speed slowly with
And the limited shortcoming of haemostatic effect.
（3）Sodium carboxymethylcellulose is introduced in alginates composite, the moisture pick-up properties of reinforcing material improves dressing
Imbibition effect, simultaneously because sodium carboxymethylcellulose is with necessarily into colloidality so that dressing is difficult viscous with wound after imbibition
Even, wound is effectively protected, the secondary injury of wound is prevented.
（4）In the modifying process of regenerated cellulose, using the generation of redox reaction, the chemistry of elemental silver is realized
Deposition, the surface of regenerated fiber forms the silver of a part of good bonding strength, so as to impart the certain bacteria resistance function of dressing.
Specific embodiment
The present invention is described further with reference to embodiment；Following examples are only used for clearly illustrating this hair
Bright object, technical solution and advantage, can not be limited the scope of the invention with this.
Embodiment 1：
A kind of compound dressing of efficient liquid-absorbent hemostatic, by sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginic acid
Salt blend fiber is prepared through needle punched non-woven fabrics processing technology.Described sodium carboxymethylcellulose/modified oxidized regenerated fiber
Plain sodium/alginate blended fiber is by the modified obtained modified oxidized regenerated cellulose and carboxymethyl cellulose of regenerated cellulose
Plain sodium, sodium alginate are prepared by wet spinning technology.
A kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic, its preparation method is comprised the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 1% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 3, lucifuge persistently stirs 2h at 35 DEG C, be then placed in 0.05mol/L ethylene glycol cleaning solution and remove
Excessive IO4 -, finally clean, freeze, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 5 times of molal quantitys, adjuvant is added, 40 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 45 DEG C dries 24h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium carboxymethylcellulose, sodium alginate powder according to
Mass ratio 1：2：9 are made into blend solution, and the stirring at 40 DEG C is until well mixed, and filtering, deaeration obtains carboxymethyl cellulose
Sodium/modified oxidized regenerated cellulose/sodium alginate co-blended spinning stoste, carboxymethyl cellulose is made by wet spinning technology
Nonwoven is made through needle punched non-woven fabrics processing technology in sodium/modified oxidized regenerated cellulose sodium/alginate blended fiber, blended fiber
Cloth coiled material, then compound dressing is made through cutting, packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：5 parts of sodium hydroxide, 40 parts of sodium acetate, carbon
150 parts of 60 parts of sour sodium and distilled water.Activating solution fraction meter by weight, 15 parts of water are dissolved in by 2 parts of silver nitrates, 0.8 part of EDTA respectively
Afterwards, mixing is carried out reacting generation precipitation, then dropwise addition ammoniacal liquor is formulated to disappearance is precipitated into the solution of generation precipitation.Adjuvant
It is formulated by following components by weight percent：4 parts of tartaric acid, concentration for 95% 15 parts of ethanol, 5 parts of butanedioic acid, 0.002 part of thiocarbamide,
EDTA0.5 parts and 70 parts of distilled water, adjuvant mixed liquor weight are the 15% of silver ammino solution.
Embodiment 2：
A kind of compound dressing of efficient liquid-absorbent hemostatic, by sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginic acid
Salt blend fiber is prepared through needle punched non-woven fabrics processing technology.Described sodium carboxymethylcellulose/modified oxidized regenerated fiber
Plain sodium/alginate blended fiber is by the modified obtained modified oxidized regenerated cellulose and carboxymethyl cellulose of regenerated cellulose
Plain sodium, sodium alginate are prepared by wet spinning technology.
A kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic, its preparation method is comprised the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 4% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 2, lucifuge persistently stirs 3h at 30 DEG C, is then placed in 0.08mol/L 1,3-PD cleaning solution,
Finally clean, freeze, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 4 times of molal quantitys, adjuvant is added, 60 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 30 DEG C dries 48h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium carboxymethylcellulose, sodium alginate powder according to
Mass ratio 2：3：9 are made into blend solution, and the stirring at 30 DEG C is until well mixed, and filtering, deaeration obtains carboxymethyl cellulose
Sodium/modified oxidized regenerated cellulose/sodium alginate co-blended spinning stoste, carboxymethyl cellulose is made by wet spinning technology
Nonwoven is made through needle punched non-woven fabrics processing technology in sodium/modified oxidized regenerated cellulose sodium/alginate blended fiber, blended fiber
Cloth coiled material, then compound dressing is made through cutting, packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：15 parts of sodium hydroxide, 30 parts of sodium acetate,
100 parts of 50 parts of sodium carbonate and distilled water.Activating solution fraction meter by weight, 18 parts are dissolved in by 1 part of silver nitrate, 0.1 part of EDTA respectively
After water, mixing is carried out reacting generation precipitation, then dropwise addition ammoniacal liquor is formulated to disappearance is precipitated into the solution of generation precipitation.Auxiliary
Agent is formulated by following components by weight percent：10 parts of ethanol, 8 parts of butanedioic acid, thiocarbamide 0.002 that 2 parts of tartaric acid, concentration are 95%
Part, EDTA0.1 parts and 80 parts of distilled water, adjuvant mixed liquor weight are the 10% of silver ammino solution.
Embodiment 3：
A kind of compound dressing of efficient liquid-absorbent hemostatic, by sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginic acid
Salt blend fiber is prepared through needle punched non-woven fabrics processing technology.Described sodium carboxymethylcellulose/modified oxidized regenerated fiber
Plain sodium/alginate blended fiber is by the modified obtained modified oxidized regenerated cellulose and carboxymethyl cellulose of regenerated cellulose
Plain sodium, sodium alginate are prepared by wet spinning technology.
A kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic, its preparation method is comprised the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 3% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 2.5, lucifuge persistently stirs 1h at 40 DEG C, is then placed in 0.1mol/L polyethylene glycol cleaning solution,
Finally clean, freeze, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 5 times of molal quantitys, adjuvant is added, 50 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 40 DEG C dries 36h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium carboxymethylcellulose, sodium alginate powder according to
Mass ratio 6：1：9 are made into blend solution, and the stirring at 45 DEG C is until well mixed, and filtering, deaeration obtains carboxymethyl cellulose
Sodium/modified oxidized regenerated cellulose/sodium alginate co-blended spinning stoste, carboxymethyl cellulose is made by wet spinning technology
Nonwoven is made through needle punched non-woven fabrics processing technology in sodium/modified oxidized regenerated cellulose sodium/alginate blended fiber, blended fiber
Cloth coiled material, then compound dressing is made through cutting, packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：10 parts of sodium hydroxide, 50 parts of sodium acetate,
200 parts of 30 parts of sodium carbonate and distilled water.Activating solution fraction meter by weight, 20 are dissolved in by 0.2 part of silver nitrate, 0.5 part of EDTA respectively
After part water, mixing react generating and precipitated, then the extremely precipitation disappearance of dropwise addition ammoniacal liquor is formulated into the solution of generation precipitation.It is auxiliary
Auxiliary agent is formulated by following components by weight percent：5 parts of ethanol, 6 parts of butanedioic acid, thiocarbamide 0.002 that 6 parts of tartaric acid, concentration are 95%
Part, EDTA2 parts and 60 parts of distilled water, adjuvant mixed liquor weight are the 18% of silver ammino solution.
Embodiment 4：
A kind of compound dressing of efficient liquid-absorbent hemostatic, by sodium carboxymethylcellulose/modified oxidized regenerated cellulose sodium/alginic acid
Salt blend fiber is prepared through needle punched non-woven fabrics processing technology.Described sodium carboxymethylcellulose/modified oxidized regenerated fiber
Plain sodium/alginate blended fiber is by the modified obtained modified oxidized regenerated cellulose and carboxymethyl cellulose of regenerated cellulose
Plain sodium, sodium alginate are prepared by wet spinning technology.
A kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic, its preparation method is comprised the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 5% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 3, lucifuge persistently stirs 2.5h at 37 DEG C, is then placed in 0.06mol/L 1,3-PD cleaning solution
In, finally clean, freeze, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 4 times of molal quantitys, adjuvant is added, 45 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 35 DEG C dries 30h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium carboxymethylcellulose, sodium alginate powder according to
Mass ratio 5：2：9 are made into blend solution, and the stirring at 50 DEG C is until well mixed, and filtering, deaeration obtains carboxymethyl cellulose
Sodium/modified oxidized regenerated cellulose/sodium alginate co-blended spinning stoste, carboxymethyl cellulose is made by wet spinning technology
Nonwoven is made through needle punched non-woven fabrics processing technology in sodium/modified oxidized regenerated cellulose sodium/alginate blended fiber, blended fiber
Cloth coiled material, then compound dressing is made through cutting, packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：8 parts of sodium hydroxide, 60 parts of sodium acetate, carbon
180 parts of 40 parts of sour sodium and distilled water.Activating solution fraction meter by weight, 10 parts of water are dissolved in by 1.5 parts of silver nitrates, 1 part of EDTA respectively
Afterwards, mixing is carried out reacting generation precipitation, then dropwise addition ammoniacal liquor is formulated to disappearance is precipitated into the solution of generation precipitation.Adjuvant
It is formulated by following components by weight percent：3 parts of tartaric acid, concentration for 95% 8 parts of ethanol, 10 parts of butanedioic acid, 0.002 part of thiocarbamide,
EDTA1 parts and 100 parts of distilled water, adjuvant mixed liquor weight are the 20% of silver ammino solution.
Experimental example 5：Hemostasis trial
Choose body weight 3.0-5.0kg new zealand rabbits and be divided into six groups, every group 6, contrast four embodiment products of the present invention and common
The anthemorrhagic performance of alginates bleeding-stopping dressing.Test dressing is cut into some pieces of 2.0cm × 2.0cm sizes, weighs, sterilize, standby.
During experiment, slowly injected after Nembutal sodium solution anesthetized animal by 40mg/kg dose intravenous, its central arteria auricularis region is standby
Skin, sterilization, skin is cut along arteria auricularis direction, and blunt separation goes out arteria auricularis, vein and nerve, then dynamic with scalpel transversely cutting
Arteries and veins, is pasted on wound surface with 1 layer of test material immediately after blood is gushed out and is applied 3N pressure, record using pull and push dynamometer
Bleeding stopping period and blood loss, and the weight of hemostatic material or dressing used in weighing respectively before and after experiment.As a result it is as shown in table 1：
The thrombotest of the compound dressing of table 1
Upper table experiment results proved, combine dressing 100s at least faster than common tourniquet bandage bleeding stopping period prepared by the present invention, because
The haemostatic effect of this product of the invention is significantly improved, and this is primarily due to play alginates and modified oxidized regeneration
The double-hemostasis function effect of cellulose.
Experimental example 6：Wettability test
NACF W1 of the certain mass in 60 DEG C of freeze-day with constant temperature to constant-quality is weighed, (the self-control of 100ml physiological saline is put into
The 0.9%NaCl aqueous solution) after immersion 1h, put into centrifuge tube, the bottom of centrifuge tube is filled with some filter paper, with receiving
The liquid dished out is centrifuged, then centrifuges centrifuge tube 20 minutes under 1500r/min, absorption is removed between fiber and fiber
Liquid.Fiber its quality taken out after centrifugation is called W2.Based on fiber is come by (W2-W1)/W1 ratios to the absorptivity of water and salt solution
Calculate.The size of absorbency is as shown in the table：
Absorbent properties of the dressing of table 2 to physiological saline
It was found from the data in upper table, preparation-obtained alginates combine dressing of the invention is to liquid（Distilled water）Absorptivity has
Significant raising.
Experimental example 7：Hygrometric state mechanical strength
Hygrometric state mechanical property test：The compound dressing of alginates using the gained of embodiment 1 ~ 4 as test sample, common alginates without
Cloth dressing is spun as control sample, each dumbbell shape standard specimen will be cut into, the damping 48h in room temperature, the environment of relative humidity 65%
With up to constant.With reference to GB/T 1040-92《Plastic tensile method for testing performance》, with CMT6104 types microcomputer controlled electronic ten thousand
Energy testing machine (newly thinking carefully measurement technology Co., Ltd in Shenzhen) determines the tensile strength of dressing under normality, rate of extension 50mm/
Min, each sample is surveyed 5 times, is averaged, and be compared with mechanical performance data under the normality of common alginate dressing；Separately
Above two alginate dressing is immersed in simulation sepage（Weigh 8.3gNaCl and 0.367gCaCl22H2O is diluted to 1L
It is standby afterwards）, it is divided into 4 groups by the difference of soak time and is tested：4h, 8h, 12h and 24h, the result measured are as shown in table 3.From
As can be seen that the product of patent of the present invention significantly improves mechanical property of the dressing under hygrometric state in table.
The normality of table 3 under each time point hygrometric state with not improving the medical bar tensile strength of alginates（Unit：MPa）
As can be seen that the more common alginates of product of the present invention, especially its mechanical strength, hygrometric state from the result of the test of table 3
Mechanical strength is significantly improved.From the foregoing, it can be seen that because introduce double carboxyls in modification regeneration cellulose, it can be with
The cross-linking process of alginic acid, moreover it is possible to alginic acid strand formation semi-interpenetrating polymer network structure, applied so as to improve and be combined
Structural intergrity, mechanical strength and the stability of material, overcoming general insufficient strength can lack under alginates adhesive-bonded fabric dressing hygrometric state
Point.The present invention further demonstrates the correctness of the viewpoint by experiment.
Claims (9)
1. a kind of compound dressing of efficient liquid-absorbent hemostatic, it is characterised in that described compound dressing is by carboxymethyl cellulose
Sodium/modified oxidized regenerated cellulose sodium/alginate blended fiber is prepared through needle punched non-woven fabrics processing technology.
2. a kind of compound dressing of efficient liquid-absorbent hemostatic according to claim 1, it is characterised in that described carboxymethyl
Sodium cellulosate/modified oxidized regenerated cellulose sodium/alginate blended fiber is by the modified obtained modification of regenerated cellulose
Oxidized regenerated cellulose is prepared with sodium carboxymethylcellulose, sodium alginate by wet spinning technology.
3. the compound dressing of a kind of efficient liquid-absorbent hemostatic according to claim 2, it is characterised in that described regeneration is fine
Tieing up plain modification procedure is：Regenerated cellulose and sodium metaperiodate are reacted, then reacted with glycol cleaning solution, obtains just aoxidizing
Regenerated cellulose, then the regenerated cellulose just aoxidized and silver ammino solution are reacted, you can modified oxidized regeneration is fine
Dimension element.
4. a kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic as described in claim any one of 1-3, its feature
It is, described preparation method is comprised the following steps that：
The first oxidation of regenerated cellulose：Regenerated cellulose is dipped into the sodium metaperiodate aqueous solution, the pH value of solution is adjusted, stirs
Mix, be then placed in 0.05 ~ 0.1mol/L glycol cleaning solution, then cleaned with high purity water, be freeze-dried to obtain what is just aoxidized
Regenerated cellulose；
The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, silver is soaked in
In ammonia solution, add adjuvant, be heated up to 40 ~ 60 DEG C, until bubble-free is produced, by product cleaning to neutrality, finally 30 ~
45 DEG C of vacuum drying chambers dry 24 ~ 48h, you can obtain modified oxidized regenerated cellulose；
The preparation of compound dressing：Modified oxidized regenerated cellulose is configured to sodium carboxymethylcellulose, sodium alginate powder
Blend solution, stirs straight well mixed, filtering, deaeration obtains sodium carboxymethylcellulose/modified oxidized regeneration at 30 ~ 50 DEG C
Cellulose/sodium alginate co-blended spinning stoste, is made sodium carboxymethylcellulose/modified oxidized regeneration fine by wet spinning technology
Non-woven fabric coiled material is made through needle punched non-woven fabrics processing technology in the plain sodium/alginate blended fiber of dimension, blended fiber, then through cutting,
Compound dressing is made in packaging, sterilizing.
5. a kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic according to claim 4, it is characterised in that institute
The step of stating（1）The mass percent of meso-periodic acid sodium water solution is 1 ~ 5%, and described pH value is 2 ~ 3, the lucifuge at 30 ~ 40 DEG C
1 ~ 3h is persistently stirred, glycol cleaning solution is ethylene glycol, 1,3-PD or polyethylene glycol.
6. a kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic according to claim 4, it is characterised in that institute
The step of stating（2）In go oil processing go fluid to be formulated by following components by weight percent：5 ~ 15 parts of sodium hydroxide, sodium acetate 30 ~
100 ~ 200 parts of 60 parts, 30 ~ 60 parts of sodium carbonate and distilled water；The activating solution of activation process is counted by weight, by 0.2 ~ 2 part of nitre
Sour silver, 0.1 ~ 1 part of EDTA are dissolved in after 10 ~ 20 parts of water respectively, and mixing carries out reaction generation precipitation, then ammoniacal liquor is added dropwise to precipitating disappearance
It is formulated.
7. a kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic according to claim 4, it is characterised in that institute
The step of stating（2）In just oxidation regenerated cellulose and silver ammino solution in solute mol ratio be 1：4~5.
8. a kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic according to claim 4, it is characterised in that institute
The step of stating（2）Middle adjuvant is formulated by following components by weight percent：2 ~ 6 parts of tartaric acid, concentration for 95% 5 ~ 15 parts of ethanol,
60 ~ 100 parts of 5 ~ 10 parts of butanedioic acid, 0.002 part of thiocarbamide, 0.1 ~ 2 part of EDTA and distilled water, and adjuvant mixed liquor weight is silver
The 10 ~ 20% of ammonia solution.
9. a kind of preparation method of the compound dressing of efficient liquid-absorbent hemostatic according to claim 4, it is characterised in that institute
The step of stating（3）In modified oxidized regenerated cellulose and sodium carboxymethylcellulose, the mass ratio of sodium alginate powder be 1 ~ 6：1~
3：9.
Priority Applications (1)
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| CN110917384A (en) * | 2019-12-14 | 2020-03-27 | 浙江惠龙医疗科技股份有限公司 | Medical dressing with antibacterial and high absorption functions and preparation method thereof |
| CN111265364A (en) * | 2018-12-04 | 2020-06-12 | 中国人民解放军军事科学院军事医学研究院 | Rapid liquid-absorbing expansion hemostasis dressing bag and preparation method and application thereof |
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