CN107089441B - Cartilage repair instrument - Google Patents
Cartilage repair instrument Download PDFInfo
- Publication number
- CN107089441B CN107089441B CN201710441429.8A CN201710441429A CN107089441B CN 107089441 B CN107089441 B CN 107089441B CN 201710441429 A CN201710441429 A CN 201710441429A CN 107089441 B CN107089441 B CN 107089441B
- Authority
- CN
- China
- Prior art keywords
- cavity
- opening
- chamber
- cartilage repair
- piston
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000000845 cartilage Anatomy 0.000 title claims abstract description 67
- 230000008439 repair process Effects 0.000 title claims abstract description 61
- 238000007789 sealing Methods 0.000 claims abstract description 63
- 239000000463 material Substances 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims description 13
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 11
- 239000000411 inducer Substances 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 7
- 230000007547 defect Effects 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000560 biocompatible material Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000470 constituent Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- 208000013201 Stress fracture Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 210000005065 subchondral bone plate Anatomy 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2/4601—Special tools for implanting artificial joints for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools for implanting artificial joints
- A61F2/4603—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4618—Special tools for implanting artificial joints for insertion or extraction of endoprosthetic joints or of accessories thereof of cartilage
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/325—Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3255—Containers provided with a piston or a movable bottom, and permitting admixture within the container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/76—Containers or packages with special means for dispensing contents for dispensing fluent contents by means of a piston
- B65D83/768—Containers or packages with special means for dispensing contents for dispensing fluent contents by means of a piston the piston or movable bottom being pulled upwards to dispense the contents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mechanical Engineering (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a cartilage repair instrument which comprises a light-tight main body with a cavity inside, wherein a first opening and a second opening of the main body are respectively arranged at two ends of the cavity, a sealing cover hermetically connected with the first opening is arranged at the first opening, a primary piston with a cavity hermetically and slidably matched with the inner surface of the primary piston is arranged in the cavity, a secondary piston arranged at the second opening is provided with a cavity sealing part hermetically and slidably matched with the cavity, a groove is dug in the outer side wall of the cavity sealing part, and the secondary piston can hermetically slide from a first position of a cavity sealing groove to a second position of the cavity without the sealing groove from the first opening to the first opening. The cartilage repair instrument disclosed by the invention can be used for storing and mixing all the components of the photosensitive cartilage repair material in a partitioned and mutually isolated manner in the same closed environment, so that the safety and the use convenience of the material are improved.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a cartilage repair instrument.
Background
The traditional cartilage repair technologies comprise microfracture, in-vitro stem cell culture transplantation, collagen and other cell-carrying scaffold technologies and the like, and the cartilage repair technologies have the problems of complex operation technology, high cell in-vitro culture cost, insufficient filling, unmatched mechanical strength, biocompatibility and the like. The cartilage repair technology adopting the scaffold material in the photosensitive mode is a development direction of the cartilage repair technology because the material has the functions of a scaffold, an induction function and integrated seamless filling, and the cartilage defect filling with expected mechanical strength can be achieved by changing liquid state into solid state through quantitative illumination.
The photosensitive cartilage repair support material is composed of three substances, namely liquid gel, a light curing agent and an inducer, the three substances are required to be separately stored before use, the three substances are uniformly mixed in proportion before use, and airtight, opaque and sterile environments are required for storage and mixing.
Disclosure of Invention
In view of the above problems, an object of the present invention is to provide a cartilage repair device, which can seal and store different substances of a photosensitive cartilage repair material in a same device in different areas according to a certain proportion, and communicate the sealed areas to form a mixed environment when in use, thereby providing a sealed, light-proof and sterile device for storing and mixing the substances of the photosensitive cartilage repair material.
In order to achieve the purpose, the invention adopts the following technical scheme:
a cartilage repair device comprising: the light-proof main body is internally provided with a cavity, the two ends of the cavity are respectively a first opening and a second opening of the main body, and the first opening is provided with a sealing cover which is in sealing connection with the first opening;
a primary piston in sealing sliding fit with the inner surface of the cavity is arranged in the cavity, and a cavity is dug at one end, far away from the first opening, of the primary piston;
a second-stage piston is arranged at the second opening and provided with a chamber sealing part in sealing sliding fit with the chamber, and a groove is formed in the outer side wall of the chamber sealing part in a digging manner;
the secondary piston is sealingly slidable from a first position in which the chamber seals the groove toward the first opening to a second position in which the chamber does not seal the groove.
Furthermore, the cavity is a blind cavity, a puncturing part capable of puncturing the bottom of the blind cavity is arranged at one end, close to the bottom of the blind cavity, of the secondary piston, the groove and the inner wall of the cavity form a sealed auxiliary storage cavity, and a sealed cavity between the sealing cover and the primary piston is a main storage cavity.
Furthermore, the cavity is a through cavity, the groove and the inner wall of the cavity form a closed auxiliary storage cavity, and a closed cavity between the sealing cover and the primary piston and between the sealing cover and the secondary piston is a main storage cavity.
Furthermore, the secondary piston is provided with a clamping limiting structure which is used for abutting against or clamping the end surface of the primary piston far away from the first opening; in the first position, the clamping limiting surface of the clamping limiting structure is far away from the end surface of the primary piston; and in the second position, the clamping limiting surface is abutted or clamped with the end surface of the primary piston.
Further, the end of the secondary piston, which is far away from the first opening, is provided with a connecting part connected with the quantitative injection instrument.
Further, the connecting part is a taper hole, a circular groove or a polygonal groove.
Furthermore, the primary piston is made of soft materials, and the secondary piston is made of hard materials.
Furthermore, the grooves dug on the outer side wall of the chamber sealing part are two grooves which are not communicated.
Further, the groove is an annular groove, a transverse groove, a longitudinal groove or an inclined groove.
Further, liquid gel is stored in the main storage cavity, and the light curing agent and the inducer are stored in the auxiliary storage cavity respectively.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following beneficial technical effects:
1. according to the cartilage repair instrument, the sealed cover, the light-tight main body with the cavity inside, the secondary piston with the grooves and the primary piston sealing the grooves and the cavity of the main body form the sealed storage space which is not communicated with each other, and all components of the photosensitive cartilage repair material are stored in the same instrument in a sealing mode in a partition mode according to the proportion.
2. According to the cartilage repair instrument, the secondary piston can slide in a sealed manner towards the first opening on the main body in the cavity of the primary piston, so that the main storage cavity and the auxiliary storage cavity are communicated with each other to form a mixed environment of the photosensitive cartilage repair material, and all components of the photosensitive cartilage repair material are stored and mixed in the same sealed environment, so that the safety and the use convenience of the material are further improved.
3. The cartilage repair instrument can be combined with a quantitative injection instrument for use, directly extrudes a uniformly mixed liquid mixture to a cartilage defect part, and is simple to operate and convenient to use.
Drawings
The drawings are only for purposes of illustrating and explaining the present invention and are not to be construed as limiting the scope of the present invention. Wherein:
FIG. 1 is a cartilage repair device according to a preferred embodiment of the present invention;
fig. 2 is a cartilage repair device according to another embodiment of the present invention.
Reference numerals:
1-sealing cover 2-main body 3-main storage cavity 4-primary piston 41-blind cavity
5-first auxiliary storage chamber 6-second auxiliary storage chamber 7-two-stage piston
Detailed Description
For better understanding of the objects, technical solutions and advantages of the present invention, the present invention will be described in further detail below with reference to the accompanying drawings in conjunction with embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The cartilage repair instrument comprises a light-tight main body 2, wherein a cavity is formed in the main body 2, a first opening and a second opening of the main body 2 are formed in two ends of the cavity respectively, a sealing cover 1 in sealing connection with the first opening is arranged at the first opening, a primary piston 4 in sealing sliding fit with the inner surface of the main body 2 is arranged in the cavity of the main body 2, a cavity is arranged at one end, far away from the first opening, of the primary piston 4, and can be a blind cavity or a through cavity, and the blind cavity is a cavity which is not communicated with the other end of the primary piston. The through cavity is a cavity communicated with the other end of the primary piston; a second-stage piston 7 is arranged at a second opening of the main body 2, the second-stage piston 7 is provided with a chamber sealing part in sealing sliding fit with the chamber, and a groove is dug in the outer side wall of the chamber sealing part; the secondary piston 7 is sealingly slidable from a first position sealing the groove of the chamber towards the first opening to a second position sealing the groove of the chamber, which may be an annular, transverse, longitudinal or inclined groove.
When the secondary piston 7 is at the first position, the cavity on the primary piston 4 seals the groove on the cavity sealing part of the secondary piston 7, so that the storage spaces of the cartilage repair instrument are sealed and are not communicated with each other, and the constituent materials are stored in a sealing manner in different areas according to the proportion required by use, thereby avoiding the pollution of the constituent materials caused by frequent uncovering and batching; when the secondary piston 7 slides to the second position from the first position to the first opening in a sealing way, the cavity does not seal the groove on the cavity sealing part of the secondary piston 7, so that the storage spaces of the cartilage repair instrument are communicated with each other to form a sealed mixed space.
In the preferred embodiment of the present invention as shown in fig. 1, the chamber is a blind cavity 41, one end of the secondary piston 7 near the bottom of the blind cavity 41 is provided with a piercing part capable of piercing the bottom of the blind cavity 41, the piercing part is specifically a pointed end, two grooves are arranged on the chamber sealing part of the secondary piston 7, the two grooves and the inner peripheral wall of the blind cavity 41 form a first secondary storage cavity 5 and a second secondary storage cavity 6 which are closed, and the closed cavity between the sealing cover 1 and the primary piston 4 is a main storage cavity 3. In the preferred embodiment, specifically, the sealing cover 1, the opaque main body 2, the primary piston 4 and the secondary piston 7 are all cylindrical structures, the first opening protrudes outward, and the sealing cover 1 and the first opening protruding outward can be directly connected in a sealing manner through a threaded structure or through a combined structure of threads and a sealing ring. The primary piston 4 is made of soft material, the blind cavity 41 is a cylindrical structure, and the blind cavity 41 is arranged at the center of one end of the primary piston 4 far away from the first opening and is parallel to the cavity. The secondary piston 7 is made of hard materials, two grooves in a cavity sealing part of the secondary piston 7 are annular grooves, and a step-shaped clamping limiting structure is further arranged on the secondary piston 7 and used for abutting against or clamping the secondary piston 7 on the end face, far away from the first opening, of the primary piston 4 when the secondary piston 7 slides to the second position from the first position towards the first opening in a sealing mode. When the secondary piston 7 is at the first position, the step surface of the step-shaped clamping limiting structure is far away from the end surface of the primary piston 4 and is parallel and opposite to the end surface, and when the secondary piston 7 slides to the second position from the first position to the first opening in a sealing manner, the step surface of the step-shaped clamping limiting structure is clamped with the end surface of the primary piston 4.
In general, the photosensitive cartilage repair material comprises three components of liquid gel, light curing agent and inducer, wherein the liquid gel is used at most and is stored in the main storage cavity 3 of the invention, the light curing agent and the inducer are used at less amount and are respectively stored in the auxiliary storage cavities 5 and 6 of the invention, and the volume of the main storage cavity 3 and the auxiliary storage cavities 5 and 6 of the invention is not less than the volume of the material to be stored in the main storage cavity and the auxiliary storage cavities 5 and 6.
With the cartilage repair device of the present invention as shown in fig. 1, when the secondary piston 7 is in the first position, the main storage chamber 3, the first secondary storage chamber 5 and the second secondary storage chamber 6 are not communicated with each other, wherein the liquid gel is stored in the closed main storage chamber 3, the light curing agent is stored in the closed first secondary storage chamber 5, the inducing agent is stored in the closed second secondary storage chamber 6, when the photosensitive cartilage repair material is required to be used, the secondary piston 7 is pushed to slide in the blind chamber 41 in a sealing manner towards the first opening, the tip on the secondary piston 7 pierces the bottom of the blind chamber 41 and then continues to slide in the blind chamber 41 in a sealing manner to the second position, so that the main storage chamber 3, the first secondary storage chamber 5 and the second secondary storage chamber 6 are communicated with each other to form a closed mixed environment, and at this time, the step surface of the clamping step-shaped limiting structure on the secondary piston 7 is clamped with the end surface on the primary piston 4, and the secondary piston 7 can no longer move towards the first opening relative to the chamber of the primary piston 4, while the chamber seal on the secondary piston 7 always seals the chamber on the primary piston 4. It can be seen that, by using the cartilage repair device of the present invention, the same sealed environment is formed from the partitioned storage environment where the main storage cavity 3, the first auxiliary storage cavity 5 and the second auxiliary storage cavity 6 are not communicated to the mixed environment where the main storage cavity 3, the first auxiliary storage cavity 5 and the second auxiliary storage cavity 6 are communicated to each other, and the sealed environment is continuously not destroyed, so that the safety of the photosensitive cartilage repair material can be ensured without being polluted.
The filling method of the cartilage repair device of the invention shown in fig. 1 comprises the following steps:
filling a specific dosage of liquid gel into the main storage cavity 3 through the first opening so as to enable the primary piston 4 to move to a specified volume position, and sealing the first opening by using the sealing cover 1 to realize the sealing of the main storage cavity 3;
and respectively filling the light curing agent and the inducer into the grooves, pushing the chamber sealing part of the secondary piston 7 into the chamber of the primary piston 4, and continuously pushing to the first position to realize the sealing of the two secondary storage cavities 5 and 6. The filling operations are all carried out in an aseptic environment.
In another embodiment of the present invention as shown in fig. 2, the chamber is a through cavity, the number of the grooves on the chamber sealing portion of the secondary piston 7 is two, the two grooves and the inner peripheral wall of the blind cavity 41 form a first auxiliary storage cavity 5 and a second auxiliary storage cavity 6 which are sealed, the sealed cavity between the sealing cover 1 and the primary piston 4 and the secondary piston 7 is a main storage cavity 3, and the end surface of the secondary piston 7 close to the first opening is a plane, but not limited to a plane.
With the cartilage repair device of the present invention as shown in fig. 2, when the secondary piston 7 is in the first position, the main storage chamber 3, the first secondary storage chamber 5 and the second secondary storage chamber 6 are not communicated with each other, wherein the liquid gel is stored in the closed main storage chamber 3, the light curing agent is stored in the closed first secondary storage chamber 5, and the inducer is stored in the closed second secondary storage chamber 6, when the photosensitive cartilage repair material is required to be used, the secondary piston 7 is pushed to slide in the through chamber towards the first opening to the second position in a sealing manner, so that the main storage chamber 3, the first secondary storage chamber 5 and the second secondary storage chamber 6 are communicated with each other to form a closed mixed environment, and the chamber sealing part on the secondary piston 7 always seals the chamber on the primary piston 4 in the whole process.
The filling method of the cartilage repair device of the invention as shown in fig. 2 comprises respectively filling specific doses of the light curing agent and the inducer into the grooves on the secondary piston 7, preferably by using a solid dry powder deposition technology, respectively attaching the light curing agent and the inducer in a dry powder state into the grooves, pushing the chamber sealing part of the secondary piston 7 into the chamber on the primary piston 4, and continuously pushing to the first position to realize the sealing of the two secondary storage chambers; the storage chamber 3 is sealed by filling a specified dose of gel from a first outlet of the main body 2 and connecting the sealing cover 1 with the first outlet in a sealing manner. The filling operations are all carried out in an aseptic environment.
Preferably, the end of the secondary piston 7 away from the opening of the main body 2 is provided with a connecting part connected with the quantitative injection device, and the connecting part is further preferably a taper hole or a circular groove or a polygonal groove, so that the cartilage repair device of the present invention is more convenient to use.
In a cartilage repair device according to the present invention as shown in fig. 1 and 2, the primary piston 4 and the secondary piston 7, which are snap-fitted together, are sealingly slidable relative to the inner surface of the body 2 toward the first outlet. When the uniformly mixed photosensitive cartilage repair material is used, the sealing cover 1 is opened, the primary piston 4 and the secondary piston 7 which are clamped together are pushed manually to slide towards the opening on the main body 2 in a sealing manner relative to the inner surface of the main body 2, the uniformly mixed liquid photosensitive cartilage repair material is extruded to the cartilage defect part from the outlet on the main body 2, and under the irradiation of specific light, the gel solidification is promoted, so that the three-dimensional seamless filling and repair of the cartilage defect part are realized. The liquid photosensitive cartilage repair material can be uniformly mixed according to a set amount and can be coated at the position of the cartilage defect of the human body by matching with an injection gun for quantitative injection, so that the waste of the material is avoided.
Preferably, the cartilage repair device of the present invention can be made as a standard unit that can be combined with a shaking device (e.g., centrifuge) or a hand shaking device, and is very convenient to use.
When the photosensitive cartilage repair material is extruded for use, the structure of the main body 2 cannot deform, and the photosensitive cartilage repair material is extruded in a single direction.
The cartilage repair instrument of the invention generally can not be reused, is a disposable instrument and ensures that the photosensitive cartilage repair material is not polluted.
The main body 2 of the cartilage repair device of the present invention is opaque, which means opaque to visible light, infrared light, ultraviolet light, and the like.
The liquid gel of the present invention is a biocompatible material, including but not limited to gels used in cartilage repair gel scaffolds, such as various hydrogels type I collagen, type II collagen, etc.; the light curing agent is also a biocompatible material, is called a photoinitiator, and promotes gel curing under the irradiation of specific light (visible light, infrared light, ultraviolet light and the like) to realize three-dimensional seamless filling and repair of cartilage defect parts; the inducer is also a biocompatible material, and comprises small molecule cartilage inducing molecules (KGN, BIO, TD-198946 and the like), and the slow release effect is realized in a cartilage repair gel scaffold, the structural design of the inducer per se realizes the controlled release effect, the cartilage repair is promoted, the growth of subchondral bone is promoted, and the aim is to reconstruct the structure and the function of natural cartilage.
The above embodiments are merely illustrative of the embodiments of the present invention, and the description is specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A cartilage repair device, comprising: the light-proof main body is internally provided with a cavity, two ends of the cavity are respectively a first opening and a second opening of the main body, and the first opening is provided with a sealing cover which is in sealing connection with the first opening;
a primary piston in sealing sliding fit with the inner surface of the cavity is arranged in the cavity, and a cavity is dug at one end, far away from the first opening, of the primary piston;
a second-stage piston is arranged at the second opening and provided with a chamber sealing part in sealing sliding fit with the chamber, and a groove is formed in the outer side wall of the chamber sealing part in a digging mode;
the secondary piston is sealingly slidable from a first position in which the chamber seals the slot toward the first opening to a second position in which the chamber does not seal the slot.
2. The cartilage repair device according to claim 1 wherein the chamber is a blind cavity, a piercing part for piercing the bottom of the blind cavity is provided at one end of the secondary piston near the bottom of the blind cavity, the groove and the inner wall of the chamber form a sealed secondary storage chamber, and the sealed cavity between the sealing cover and the primary piston is a primary storage chamber.
3. The cartilage repair device of claim 1 wherein the chamber is a through cavity, the groove and the inner wall of the chamber form a sealed secondary storage cavity, and the sealed cavity between the seal cap and the primary and secondary pistons is a primary storage cavity.
4. The cartilage repair device of claim 1 wherein the secondary piston is provided with a snap-fit limit structure for abutting against or snap-fitting onto an end face of the primary piston remote from the first opening; in the first position, the clamping limiting surface of the clamping limiting structure is far away from the end surface of the primary piston; and in the second position, the clamping limiting surface is abutted against or clamped with the end surface of the primary piston.
5. The cartilage repair device of claim 1 wherein an end of the secondary piston distal to the first opening is provided with a coupling for connection to a dosing instrument.
6. The cartilage repair device of claim 5 wherein the connecting portion is a tapered hole, a circular groove or a polygonal groove.
7. The cartilage repair device of claim 1 wherein the primary piston is a soft material and the secondary piston is a hard material.
8. The cartilage repair device of claim 2 or 3 wherein the outer side wall of the chamber seal is hollowed out to form two slots that are not connected.
9. The cartilage repair device of claim 1 wherein the groove is an annular groove, a transverse groove, a longitudinal groove, or an angled groove.
10. The cartilage repair device of claim 8 wherein the two grooves and the inner peripheral wall of the chamber define sealed first and second secondary reservoirs, the primary reservoir storing a liquid gel, the first and second secondary reservoirs storing a light curing agent and an inducing agent, respectively.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710441429.8A CN107089441B (en) | 2017-06-13 | 2017-06-13 | Cartilage repair instrument |
| PCT/CN2017/107568 WO2018227838A1 (en) | 2017-06-13 | 2017-10-25 | Cartilage repair instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710441429.8A CN107089441B (en) | 2017-06-13 | 2017-06-13 | Cartilage repair instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107089441A CN107089441A (en) | 2017-08-25 |
| CN107089441B true CN107089441B (en) | 2020-06-02 |
Family
ID=59640125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710441429.8A Active CN107089441B (en) | 2017-06-13 | 2017-06-13 | Cartilage repair instrument |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN107089441B (en) |
| WO (1) | WO2018227838A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107089441B (en) * | 2017-06-13 | 2020-06-02 | 苏州中科生物医用材料有限公司 | Cartilage repair instrument |
| CN110522535B (en) * | 2019-07-02 | 2021-10-26 | 中南大学湘雅医院 | Separating device for partitioned bone tendon interface support |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2286658A1 (en) * | 1974-10-01 | 1976-04-30 | Ferri Pisani Jerome | Injection syringe with storage for pharmaceutical prods - to be mixed only just before use |
| DK17890A (en) * | 1990-01-22 | 1991-07-23 | Novo Nordisk As | METHOD AND APPARATUS FOR MIXTURE AND INJECTION OF A MEDICINE |
| US5586975A (en) * | 1994-02-18 | 1996-12-24 | Takeda Chemical Industries. Ltd. | Air and liquid tight container with a slidable gasket |
| DE4409610C3 (en) * | 1994-03-21 | 2001-09-20 | Scandimed Internat Ab Sjoebo | Mixing device |
| US20060084909A1 (en) * | 2004-07-12 | 2006-04-20 | Chung Yuan Christian University | Syringe with separate cavities |
| ITVI20050152A1 (en) * | 2005-05-20 | 2006-11-21 | Tecres Spa | CARTRIDGE FOR CONSERVATION AND STERILE DISTRIBUTION OF A BIPHASIC COMPOUND, PARTICULARLY FOR AN ACRYLIC RESIN |
| KR20090041405A (en) * | 2006-08-22 | 2009-04-28 | 메드믹스 시스템즈 아게 | Method and apparatus for storing, mixing and dispensing elements |
| BRPI1002819B1 (en) * | 2010-01-25 | 2019-11-05 | Tecres Spa | device for preparing and administering a two-component mixture |
| CN202844260U (en) * | 2012-10-30 | 2013-04-03 | 无锡耐思生物科技有限公司 | Injection mixing pre-filling and pre-sealing injector structure |
| CN105939743A (en) * | 2013-11-27 | 2016-09-14 | 尼普洛株式会社 | Prefilled syringe |
| SMT201800324T1 (en) * | 2014-07-22 | 2018-07-17 | Orofino Pharm Group Srl | Pre-filled injection device |
| CN106179075B (en) * | 2015-04-30 | 2019-06-21 | 奥然生物科技（上海）有限公司 | A kind of material point deposits formula mixing arrangement |
| CN206871708U (en) * | 2017-06-13 | 2018-01-12 | 江苏奥康尼医疗科技发展有限公司 | A kind of repair of cartilage apparatus |
| CN107089441B (en) * | 2017-06-13 | 2020-06-02 | 苏州中科生物医用材料有限公司 | Cartilage repair instrument |
-
2017
- 2017-06-13 CN CN201710441429.8A patent/CN107089441B/en active Active
- 2017-10-25 WO PCT/CN2017/107568 patent/WO2018227838A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN107089441A (en) | 2017-08-25 |
| WO2018227838A1 (en) | 2018-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11160594B2 (en) | Bone cement applicator with a closable gas supply opening | |
| US11109905B2 (en) | Bone cement applicator with retractable mixing rod and method for production of a bone cement | |
| CA2878738C (en) | Device for storing and mixing bone cement | |
| ES2049959T3 (en) | A PROCEDURE AND DEVICE FOR PREPARING A MIXTURE OF A SOLID COMPONENT AND A LIQUID COMPONENT. | |
| CN107089441B (en) | Cartilage repair instrument | |
| CA2959886C (en) | Storage and mixing system for pasty cement components and method therefor | |
| CA2959883C (en) | Storage and mixing system for pasty cement components and method therefor | |
| US20150060489A1 (en) | Metering device for the manually-controlled metering of a light-curing material, kit, and method | |
| JP2007125553A (en) | Coating apparatus | |
| DE102015116797A1 (en) | Apparatus and method for storing and mixing a bone cement | |
| JP2018143762A (en) | Storing and mixing apparatus having two product construction for bone cement product and relating method | |
| AU2019204008C1 (en) | Bone cement applicator with retractable mixing rod and method for production of a bone cement | |
| CN206871708U (en) | A kind of repair of cartilage apparatus | |
| JP6129229B2 (en) | Syringe | |
| CN219110446U (en) | Implant injector | |
| JP2004254782A (en) | Medical paste knead syringe and medical paste knead syringe material | |
| WO2013141188A1 (en) | Drug injection device | |
| CN110870788A (en) | Chemical reagent extrusion auxiliary tool and method for extruding chemical reagent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181212 Address after: Room 494, 4-storey A, No. 84-86-2 Jinghua Road, Xujing Town, Qingpu District, Shanghai, 2010 Applicant after: Shanghai active biotechnology service center Address before: Room 606, No. 9 Changchun North Road, Chengxiang Town, Taicang City, Suzhou City, Jiangsu Province Applicant before: JIANGSU OKANI MEDICAL TECHNOLOGY CO., LTD. |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20190313 Address after: 215000 East of No. 52 Workshop of Chuangdu Industrial Workshop, Loujinbei District, Suzhou Industrial Park, Jiangsu Province Applicant after: Suzhou Zhongke Biomedical Material Co., Ltd. Address before: Room 494, 4-storey A, No. 84-86-2 Jinghua Road, Xujing Town, Qingpu District, Shanghai, 2010 Applicant before: Shanghai active biotechnology service center |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |