CN107085023A - A kind of electrochemica biological sensor and preparation method thereof - Google Patents
A kind of electrochemica biological sensor and preparation method thereof Download PDFInfo
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Abstract
The present invention is a kind of electrochemica biological sensor and preparation method thereof, front side conductive layer and reverse side conductive layer that this biology sensor is had nothing in common with each other in the obverse and reverse of substrate, also different front reagent blocks and reverse side reagent block, 2 cover plates are covered each by positive and negative reagent block.Positive and negative reagent block includes at least one enzyme and a kind of electron mediator with example reaction.Front side conductive layer has 3 electrodes, and reverse side conductive layer has 2 electrodes.Preparation method is：Printed on the positive back face printing or magnetron sputtering conductive layer of substrate, conductive layer and positive and negative reagent block is placed in insulating barrier, insulating barrier front end groove；The padded layer surface pasted with insulating barrier and reagent block is fitted cover plate.The present invention tests two kinds of compositions in a sample simultaneously, and user reduces blood sampling；Suitable for the detection of the projects such as glucose, uric acid, cholesterol；The number of electrodes of positive and negative conductive layer is inconsistent, beneficial to identification, is conveniently correctly inserted into tester.
Description
Technical field
The present invention relates to external diagnosis reagent technical field, more particularly to a kind of electrochemica biological sensor and its making side
Method.
Background technology
Biology sensor is the molecule distinguishability using biomaterials such as microorganism, enzyme, antibody, DNA, RNA, to sample
In the sensor that is quantitatively detected of matrix content.According to quantitative analysis method, can be classified as optical biosensor or
Electrochemica biological sensor.These biology sensors are used for the detection of various analytes, and rapid disease examination, such as glycosuria
Disease, high fat of blood etc..
In medical field, disposable electrochemica biological sensor (such as strip) has been used for blood glucose, uric acid, cholesterol parameter
Measure, when blood sample imports electrochemica biological sensor, it may occur that electrochemical reaction is so as to producing electric signal, by telecommunications
Number transmit to the measure device being engaged with electrochemica biological sensor, you can obtain the detected value of relevant parameter.
But existing electrochemica biological sensor be can only be in determination sample a kind of parameter.For example, existing market
The blood glucose strip of upper existing many brands, the structure of these blood glucose strips is very similar, only has a conversion zone in strip,
A blood glucose project can only be tested.A small number of blood glucose meters can test multiple project indicators, and different examinations is used it also requires changing
Paper, could realize the detection of multiple project indicators, for example the ET-301 types blood glucose of Jinxin Biological Science ＆ Technology Co., Ltd.'s production/
Uric acid/cholesterol multi-functional analyzer (trade name:Yi Li is surveyed), if user thinks to detect blood glucose and other physiological parameters simultaneously,
Different test paper must be used instead.In a word, multiple physiological parameters in blood are determined as patient, it is necessary to use multiple sample, also
It is to gather more blood samples from a patient, the pain of increase patient and the loss of blood.
The content of the invention
The purpose of the present invention is a kind of electrochemica biological sensor of design, and it has two reaction zones domain, two reaction zones domain
The different combinations of reactants of middle storage, with two kinds of different components in sample size once simultaneously test sample, produces two reactions
Signal, the determining instrument being engaged provides two kinds of related parameter measured values of sample according to reaction signal.
A kind of design of electrochemica biological sensor of the present invention is as follows：Including substrate, conductive layer, reagent block and lid
Plate, substrate is the rectangular slab of insulation, a length of 30~40mm, a width of 5~10mm；Conductive layer is the electrode electricity for being attached to substrate
Road, the chemical reagent that is engaged with the composition in certain biological sample of reagent block storage, reagent block be placed in conductive layer one end and
The preceding end in contact of electrode, cover plate covering reagent block；The present invention substrate the front side conductive layer had nothing in common with each other of obverse and reverse and
Reverse side conductive layer, also different front reagent block and reverse side reagent block, 2 cover plates are covered each by front reagent block and reverse side examination
Agent block.
Front or back conductive layer has 3 electrodes, and another side conductive layer has 2 electrodes.
Front side conductive layer and reverse side conductive layer are covered with insulating barrier, and dielectric width is identical with substrate, insulating barrier and substrate
Front end flush, insulating barrier length is the 2/3 to 4/5 of substrate, and insulating barrier is covered in before front side conductive layer and reverse side conductive layer
Termination electrode after portion, exposed front surface conductive layer and reverse side conductive layer, in order to which the measure end with determining instrument connects.Insulating barrier front end
There is the rectangular recess being engaged with front reagent block or reverse side reagent block at middle part.
The reagent block is rectangle, and width is substrate 1/5~1/3, and length-width ratio is (2~4)/1.
Pad level is in both connections between insulating barrier and cover plate.Pad level front center has and front reagent block or reverse side
The rectangular recess that reagent block is engaged, front reagent block and reverse side reagent block are embedded in the groove of pad level.Pad level width with
Substrate is identical, and length is 1.2~2 times of front reagent block and reverse side reagent block length.
Cover plate is identical with the length and width of pad level, covering pad level and reagent block.Substrate, front reagent block, reverse side reagent block,
The front end of 2 pad levels and 2 cover plates is concordant with left and right sides.
The substrate front center is jagged, in favor of Sample introduction, and this breach is 0.8~1.5mm of diameter semicircle
Breach.
The cover plate makes for hydrophilic plastic, has 1~3 row on the position of correspondence front reagent block and reverse side reagent block
Gas aperture, 0.3~0.8mm of aperture.
Front reagent block or reverse side the reagent block includes at least one enzyme and a kind of electron mediator with example reaction,
The enzyme is any of glucose oxidase, glucose dehydrogenase, cholesterol oxidase, urate oxidase, electronic media
Body is any of the potassium ferricyanide, Ferrocene and its derivative, the complex compound of ruthenium, benzoquinone compound.
Front reagent block and reverse side the reagent block also contains surfactant and buffer solution, and the surfactant is each
Kind anionic, cationic, non-ionic and amphoteric ionic surfactant is APEO, sodium taurocholate, carboxymethyl
Any of sodium cellulosate, cetylpyridinium chloride；The buffer solution is phosphate buffer, TRIS buffer solutions (three hydroxyl first
Any of base aminomethane buffer solution) and MES buffer solutions (2- (N- morpholines) ethanesulfonic acid buffer).
A kind of preparation method of electrochemica biological sensor of the present invention is as follows：
Ith, substrate
From PET (PET), polyvinyl chloride (PVC), any of polypropylene (PP) makes length
Square substrate；Most preferably PET substrate；
IIth, conductive layer
In obverse and reverse the electrically conductive ink silk-screen printing front side conductive layer and the telegraph circuit of reverse side conductive layer of substrate,
The electrically conductive ink is electric conductive carbon printing ink or Conductive silver ink；
Or, front side conductive layer and reverse side conductive layer are obtained with magnetron sputtering conducting metal in the obverse and reverse of substrate
Any of telegraph circuit, gold, palladium and nickel that the metal is；
IIIth, insulating barrier
One layer insulating of each printing, insulating barrier front center in the front side conductive layer and reverse side conductive layer completed in step II
The rectangular recess being engaged with reagent block is reserved, insulating barrier length is the 2/3 to 4/5 of substrate, exposed front surface conductive layer and reverse side
The electrode of conductive layer rear end；
IVth, reagent block
Front reagent block and reverse side are placed respectively in the rectangular recess for the obverse and reverse insulating barrier front end that step III is completed
Reagent block；The conducting layer electrode of front reagent block and reverse side reagent block respectively with front side conductive layer and reverse side is in contact；
Vth, pad level
Pad level is double coated film, and the pad level for removing a surface protective film is covered in the insulating barrier and reagent of obverse and reverse
On block, pasted with insulating barrier and reagent block, reagent block is embedded in the rectangular recess of pad level front end；
VIth, cover plate
Another surface protective film of the pad level of obverse and reverse is removed after the completion of step V, the pad level of obverse and reverse
Surface is respectively fitted a piece of cover plate.
Compared with prior art, a kind of advantage of electrochemica biological sensor of the invention and preparation method thereof is：1st, this life
The positive and negative of thing sensor base plate has conductive layer, forms two independent test reaction regions, and have different reagent blocks, two
Reaction reagent on individual conversion zone will not interfere influence test result, while testing two kinds of compositions in a sample, subtract
The pain that few user brings because repeatedly taking a blood sample；It is particularly suitable for use in the detection of the projects such as glucose, uric acid, cholesterol；2nd, this life
The number of electrodes of thing sensor positive and negative conductive layer is inconsistent, so that tester differentiates the positive and negative of this sensor, correctly
Ground insert tester, test device also can determine whether sensor insertion direction, when reverse side upward when test device provide insertion
The prompting of mistake, it is to avoid because test paper misuse obtains error result；3rd, production equipment and technique used and with existing bio-sensing
Device making apparatus is similar with technique, and such a new product is easy to produce in prior art basis.
Brief description of the drawings
Fig. 1 is each exploded sketch of this electrochemica biological sensor embodiment；
Fig. 2 is this electrochemica biological sensor embodiment front schematic view；
Fig. 3 is this electrochemica biological sensor embodiment side schematic view；
Fig. 4 is this electrochemica biological sensor embodiment reverse side schematic diagram.
1st, cover plate, 2, pad level, 3, front reagent block, 4, insulating barrier, 5, front side conductive layer, 6, substrate, 7, reverse side it is conductive
Layer, 8, reverse side reagent block.
Embodiment
Electrochemica biological sensor embodiment
As shown in Figures 1 to 4, this spr substrate 6 is the rectangular slab of insulation to this electrochemica biological sensor embodiment, a length of
35mm, a width of 7mm；Front side conductive layer 5 and reverse side conductive layer 7 that the obverse and reverse of substrate 6 is had nothing in common with each other, this example front side conductive
Layer 5 has 3 electrodes, and reverse side conductive layer 7 has 2 electrodes.This example front side conductive layer 5 and reverse side conductive layer 7 are covered with insulating barrier 4,
The width of insulating barrier 4 is identical with substrate 6, insulating barrier 4 and the front end flush of substrate 6, and the length of insulating barrier 4 is the 3/4 of substrate 6, insulation
Layer 4 is covered in the electricity of the front portion of front side conductive layer 5 and reverse side conductive layer 7, exposed front surface conductive layer 5 and the rear end of reverse side conductive layer 7
Pole, the front center of insulating barrier 4 has the rectangular recess being engaged with front reagent block 3 or reverse side reagent block 8.The He of front reagent block 3
8 pieces of reverse side reagent is rectangle, and width is the 1/4 of substrate 6, and length-width ratio is 3/1.
Pad level 2 is between insulating barrier 4 and cover plate 1, both connections；The front center of pad level 2 has and front reagent block 3
Or the rectangular recess that reverse side reagent block 8 is engaged, front reagent block 3 and reverse side reagent block 8 are embedded in the groove of pad level 2；
The width of pad level 2 is identical with substrate 6, and length is 1.5 times of front reagent block 3 or the length of reverse side reagent block 8.
This example cover plate 1 is made for hydrophilic plastic, identical with the length and width of pad level 2, and the He of pad level 2 is covered in obverse and reverse
Front reagent block 3 or reverse side reagent block 8；This spr substrate 6, front reagent block 3, reverse side reagent block 8,2 pieces of pad levels 2 and 2 lids
The front end of plate is concordant with left and right sides.
This example cover plate 1, has 3 exhaust holes, aperture on the position of correspondence front reagent block 3 and reverse side reagent block 8
0.5mm。
The front center of this spr substrate 6 has 0.8~1.5mm of diameter semicircular indentations.
This electrochemical sensor can be used for blood glucose, packed cell volume, cholesterol, triglycerides, uric acid, lactate, acetone
Detected while any two kinds of analytes in hydrochlorate.
In this electrochemica biological sensor embodiment, target analytes are the glucose and cholesterol in blood.It is positive anti-
The enzyme for answering reagent block to contain is glucose oxidase, and electron mediator is the potassium ferricyanide, and surfactant is APEO, is delayed
Fliud flushing is phosphate buffer.The enzyme that apofacial reaction reagent block 8 contains is cholesterol Esterified Enzyme, electron mediator, surfactant
And buffer solution and front reagent block 3 is identical.
The preparation method embodiment of electrochemica biological sensor
The preparation method of this electrochemica biological sensor is to be used to make above-mentioned electrochemica biological sensor embodiment, step
It is as follows：
Ith, substrate 6
A length of 35mm, a width of 7mm rectangular substrate 6 are made from poly terephthalic acid second two；
IIth, conductive layer
In the electrode electricity of obverse and reverse electrically conductive ink silk-screen printing front side conductive layer 5 and the reverse side conductive layer 7 of substrate 6
Road, the electrically conductive ink of this example is electric conductive carbon printing ink；
IIIth, insulating barrier 4
One layer insulating 4 of each printing, the front end of insulating barrier 4 in the front side conductive layer 5 and reverse side conductive layer 7 completed in step II
Middle part reserves the rectangular recess being engaged with reagent block, and the length of insulating barrier 4 is the 3/4 of substrate 6, exposed front surface conductive layer 5 and anti-
Termination electrode after face conductive layer 7；
IVth, reagent block
Front reagent block 3 is placed in the rectangular recess for the front end of obverse and reverse insulating barrier 4 that step III is completed respectively and anti-
Interview agent block 8；Front reagent block 3 and reverse side reagent block 8 respectively with front side conductive layer 5 and the contact electrode of reverse side conductive layer 7；
Vth, pad level 2
This example pad level 2 is double coated film, and the pad level 2 for removing a surface protective film is covered in the insulating barrier of obverse and reverse
4 and reagent block on, pasted with insulating barrier 4 and reagent block, reagent block is embedded in the rectangular recess of the front end of pad level 2；
VIth, cover plate 1
Another surface protective film of the pad level 2 of obverse and reverse is removed after the completion of step V, obverse and reverse it is padded
Respectively fit a piece of cover plate 1 on 2 surface of layer.
Above-described embodiment, is only to the specific of the purpose of the present invention, technical scheme and beneficial effect further description
Individual example, the present invention is not limited to this.All any modifications made within the scope of disclosure of the invention, equivalent substitution, change
Enter, be all contained within protection scope of the present invention.
Claims (10)
1. a kind of electrochemica biological sensor, including substrate (6), conductive layer, reagent block and cover plate (1), substrate (6) are insulation
Rectangular slab, a length of 30~40mm, a width of 5~10mm；Conductive layer is the telegraph circuit for being attached to substrate (6), the storage of reagent block
The chemical reagent being engaged with the composition in certain biological sample, reagent block is placed in one end of conductive layer, the preceding termination with electrode
Touch, cover plate (1) covering reagent block；It is characterized in that：
Front side conductive layer (5) and reverse side conductive layer (7) that the obverse and reverse of the substrate (6) is had nothing in common with each other are also different
Front reagent block (3) and reverse side reagent block (8), 2 cover plates (1) are covered each by front reagent block (3) and reverse side reagent block (8).
2. electrochemica biological sensor according to claim 1, it is characterised in that：
The front or back conductive layer (5) has 3 electrodes, and another side conductive layer (7) has 2 electrodes.
3. electrochemica biological sensor according to claim 1 or 2, it is characterised in that：
The front side conductive layer (3) and reverse side conductive layer (7) are covered with insulating barrier (4), insulating barrier (4) width and substrate (6) phase
Together, insulating barrier (4) and substrate (6) front end flush, insulating barrier (4) length is the 2/3 to 4/5 of substrate (6), and insulating barrier (4) covers
It is placed on the front portion of front side conductive layer (5) and reverse side conductive layer (7), exposed front surface conductive layer (5) and reverse side conductive layer (7) rear end
Electrode, insulating barrier (4) front center has the rectangular recess being engaged with front reagent block (3) or reverse side reagent block (8).
4. electrochemica biological sensor according to claim 1 or 2, it is characterised in that：
The front reagent block (3) and reverse side reagent (8) block are rectangle, and width is substrate (6) 1/5~1/3, and length-width ratio is
(2~4)/1.
5. electrochemica biological sensor according to claim 3, it is characterised in that：
Pad level (2) is between insulating barrier (4) and cover plate (1), both connections；Pad level (2) front center has with just interviewing
The rectangular recess that agent block (3) or reverse side reagent block (8) are engaged, front reagent block (3) and reverse side reagent block (8) are embedded in pad level
(2) in the groove；Pad level (2) width is identical with substrate (6), and length is that front reagent block (3) or reverse side reagent block (8) are long
1.2~2 times of degree.
6. electrochemica biological sensor according to claim 5, it is characterised in that：
The cover plate (1) is identical with the length and width of pad level (2), covering pad level (2) and front reagent block (3) or reverse side reagent block
(8)；The substrate (6), front reagent block (3), reverse side reagent block (8), the front end of 2 pieces of pad levels (2) and 2 cover plates (1) and
Left and right sides is concordant.
7. electrochemica biological sensor according to claim 1 or 2, it is characterised in that：
The cover plate (1) is that hydrophilic plastic makes, have 1 on the position of correspondence front reagent block (3) and reverse side reagent block (8)~
3 exhaust holes, 0.3~0.8mm of aperture.
8. electrochemica biological sensor according to claim 1 or 2, it is characterised in that：
Substrate (6) front center is jagged, and this breach is 0.8~1.5mm of diameter semicircular indentations.
9. electrochemica biological sensor according to claim 1, it is characterised in that：
The enzyme of the front reagent block (3) or reverse side reagent block (8) comprising at least one and example reaction, also a kind of electronics matchmaker
Amboceptor, the enzyme is any of glucose oxidase, glucose dehydrogenase, cholesterol oxidase, urate oxidase, described
Electron mediator is any of the potassium ferricyanide, Ferrocene and its derivative, the complex compound of ruthenium, benzoquinone compound.
10. the preparation method of electrochemica biological sensor according to claim 5, it is characterised in that step is as follows：
Ith, substrate (6)
From PET, polyvinyl chloride, any of polypropylene makes rectangular substrate；
IIth, conductive layer
In obverse and reverse the electrically conductive ink silk-screen printing front side conductive layer (5) and the electrode of reverse side conductive layer (7) of substrate (6)
Circuit, the electrically conductive ink is electric conductive carbon printing ink or Conductive silver ink；
Or, front side conductive layer (5) and reverse side conductive layer are obtained with magnetron sputtering conducting metal in the obverse and reverse of substrate (6)
(7) telegraph circuit, the metal is any of gold, palladium and nickel；
IIIth, insulating barrier (4)
One layer insulating of each printing (4), insulating barrier (4) in the front side conductive layer (5) and reverse side conductive layer (7) completed in step II
Front center reserves the rectangular recess being engaged with reagent block, and insulating barrier (4) length is the 2/3 to 4/5 of substrate (6), and exposure is just
Face conductive layer (5) and reverse side conductive layer (7) termination electrode afterwards；
IVth, reagent block
Front reagent block (3) is placed in the rectangular recess of obverse and reverse insulating barrier (4) front end that step III is completed respectively and anti-
Interview agent block (8)；Front reagent block (3) and reverse side reagent block (8) respectively with front side conductive layer (5) and reverse side conductive layer (7)
Contact electrode；
Vth, pad level (2)
Pad level (2) is double coated film, and the pad level (2) for removing a surface protective film is covered in the insulating barrier (4) of obverse and reverse
On reagent block, pasted with insulating barrier (4) and reagent block, reagent block is embedded in the rectangular recess of pad level (2) front end；
VIth, cover plate (1)
Another surface protective film of the pad level (2) of obverse and reverse is removed after the completion of step V, the pad level of obverse and reverse
(2) surface is respectively fitted a piece of cover plate (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710316621.4A CN107085023A (en) | 2017-05-08 | 2017-05-08 | A kind of electrochemica biological sensor and preparation method thereof |
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| CN201710316621.4A CN107085023A (en) | 2017-05-08 | 2017-05-08 | A kind of electrochemica biological sensor and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108508074A (en) * | 2018-04-29 | 2018-09-07 | 浙江大学山东工业技术研究院 | A kind of anti-interference dual-port screen printing electrode |
| CN109115854A (en) * | 2018-10-10 | 2019-01-01 | 成都华芯微医疗科技有限公司 | The test strips of joint test and the preparation method and application thereof that are a kind of while measuring two kinds of blood parameters |
| CN110940713A (en) * | 2019-12-31 | 2020-03-31 | 郑州信德医疗科技有限公司 | Double-sided blood glucose test paper and double-numerical-value display glucometer |
| CN112415063A (en) * | 2020-12-02 | 2021-02-26 | 武汉市农业科学院 | Heavy metal detector |
| CN113125528A (en) * | 2020-01-14 | 2021-07-16 | 利多(香港)有限公司 | Electrochemical test strip for multi-index parameter detection and detection method |
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| US20070131548A1 (en) * | 2005-12-12 | 2007-06-14 | Nova Biomedical Corporation | Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108508074A (en) * | 2018-04-29 | 2018-09-07 | 浙江大学山东工业技术研究院 | A kind of anti-interference dual-port screen printing electrode |
| CN109115854A (en) * | 2018-10-10 | 2019-01-01 | 成都华芯微医疗科技有限公司 | The test strips of joint test and the preparation method and application thereof that are a kind of while measuring two kinds of blood parameters |
| CN110940713A (en) * | 2019-12-31 | 2020-03-31 | 郑州信德医疗科技有限公司 | Double-sided blood glucose test paper and double-numerical-value display glucometer |
| CN113125528A (en) * | 2020-01-14 | 2021-07-16 | 利多(香港)有限公司 | Electrochemical test strip for multi-index parameter detection and detection method |
| WO2021143730A1 (en) * | 2020-01-14 | 2021-07-22 | 利多(香港)有限公司 | Electrochemical test strip for testing multiple indicators, and testing method thereof |
| CN112415063A (en) * | 2020-12-02 | 2021-02-26 | 武汉市农业科学院 | Heavy metal detector |
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