CN107064048A - A kind of quick Noninvasive Blood Glucose Detection Methods and device - Google Patents

Abstract

The invention provides a rapid non-invasive blood sugar detection method and device. Using the method of minimally invasive blood sugar collection, detect the blood sugar content of the middle finger of the human body; and use the rapid non-invasive blood sugar detection device to collect the corresponding near-infrared spectral data of the human body; combine the collected blood sugar content and blood sugar near-infrared spectral data with the multiple linear regression method, Establish a prediction model of human blood sugar content; wirelessly transmit the spectral data to the Android development board through the Bluetooth low-power module; analyze the spectral data on the Android development board, and display the blood sugar content in real time. The method and device of the present invention, based on the near-infrared spectrum-Bluetooth low power consumption technology, can quickly and non-invasively detect the blood sugar content of a single individual, and has the function of software model optimization. Compared with the traditional invasive method, it not only reduces the patient's Pain, but also to avoid wound infection, can be used to guide diabetics to adjust the dosage of oral hypoglycemic drugs and insulin.

Description

A rapid non-invasive blood glucose detection method and device

technical field

The invention relates to a technology and equipment for rapid and non-invasive detection of blood sugar, in particular to a method and device for rapid and non-invasive detection of blood sugar content in a human body by using near-infrared spectrum technology and Bluetooth low-power wireless transmission technology.

Background technique

With the increasing emphasis on health, routine physical examination and preventive treatment have been widely recognized by people. However, due to the accelerated pace of work and life in modern society, human blood sugar-related diseases have occurred. Diabetes is a typical chronic disease that requires long-term and frequent monitoring. It can cause a series of metabolic disorders in the human body and is known as the second killer of modern diseases.

The main means of monitoring diabetes is to effectively control the blood sugar concentration by frequently detecting the blood sugar concentration and adjusting the dosage of oral hypoglycemic drugs and insulin based on it accurately and timely. The blood glucose test widely used by the public is a (minimally) invasive way of dripping blood or finger blood plus test strips. Usually, the test needs to be tested several times a day. Although it is a minimally invasive blood test, users still generally report that this kind of test is annoying , there is an urgent need for a non-invasive blood glucose measuring instrument on the market to solve these problems.

The blood glucose meter in the Chinese patent application number CN201520880188.3 needs to collect blood samples for blood glucose content analysis, and the instrument operation interface does not have good human-computer interaction. As the finger pricks the needle to draw blood, it causes pain to the tester and there is a risk of infection. If things go on like this, the stinging pain of blood collection will also lead to a decline in the enthusiasm of patients for blood sugar testing. If blood sugar testing cannot be maintained for a long time, the test data will be too small to reflect the control and change trend of blood sugar.

Near-infrared spectroscopy is an electromagnetic wave containing near-infrared (NIR), with a corresponding wavelength range of 900-1700nm. It has been widely used in the rapid detection of internal components in solids and liquids, and is more feasible in optical methods. A non-invasive blood glucose detection method.

The Chinese patent application number is CN200920205457.0 in the non-invasive blood sugar detection system. Although the near-infrared spectrum technology is used for non-invasive blood sugar detection, its light transmission module and light detection module must transmit spectral data through optical fibers, which is bloated in design and not easy to carry; its function Single, does not have the function suitable for individual difference detection, software self-optimization model function, and cannot effectively analyze the change trend of human blood sugar.

Therefore, finding a portable rapid non-invasive human blood glucose detection method and device with reasonable design and high integration has wide clinical application and promotion significance. The present invention adopts a highly integrated portable near-infrared spectrometer to obtain the diffuse reflectance spectrum of the finger of the subject to be tested, and combines the conventional minimally invasive blood drop method to obtain the real blood sugar content of the human body; the obtained near-infrared spectrum information and blood sugar content are obtained through the corresponding Chemometrics method to establish a corresponding blood sugar concentration prediction model; based on Bluetooth low-power wireless transmission technology, the rapid quantitative analysis of human blood sugar can be realized on the mobile phone client; after the increase in the blood sugar database in the later stage, the function of the software optimization model can improve the human body. Accuracy of blood glucose testing.

Contents of the invention

The purpose of the present invention is to provide a fast non-invasive blood sugar detection method and device based on near-infrared spectrum-Bluetooth low power consumption technology, so as to realize fast non-invasive quantitative analysis of human blood sugar, and guide diabetic patients to adjust oral hypoglycemic drugs and Insulin dosage.

For the method and device of the present invention, the technical scheme specifically adopted is as follows:

A fast non-invasive blood glucose detection method, characterized in that it comprises the following steps:

Step 1, minimally invasive collection and detection of blood sugar levels: according to the time points before breakfast, before lunch, and before going to bed every day, for one week, use a conventional minimally invasive blood glucose meter to measure the blood sugar content of the sample by means of acupuncture blood collection, and obtain the conventional micro-glucose blood glucose meter. The blood glucose value measured by the blood glucose meter;

Step 2, collection of near-infrared spectrum data of blood sugar: using the light source module as the signal source, the portable near-infrared spectrum module receives the diffuse reflectance spectrum of blood sugar, performs fast and non-invasive blood sugar spectrum collection, and obtains near-infrared spectrum data of blood sugar;

Step 3, optimization analysis of the blood sugar detection model: combine the collected near-infrared spectrum data of blood sugar with the blood sugar value measured by the conventional minimally invasive blood glucose meter, and combine the multiple linear regression method to establish the blood sugar detection model;

Step 4, non-invasive detection of blood sugar content: connect to the Android development board supporting Bluetooth 4.0 through the Bluetooth low-power module, and wirelessly transmit the near-infrared spectrum data of blood sugar; Individuals undergo non-invasive blood glucose testing.

The time nodes before breakfast, before lunch, and before going to bed in the first step are universal to the population and conform to the daily routine of the public; the duration of the week is specifically to collect 21 blood sugar content values for subsequent establishment of a blood sugar detection model The method of acupuncture blood collection is specifically to collect a drop of blood from the middle finger, and the human body has no obvious pain.

The light source module is integrated with the near-infrared spectrum module and the Bluetooth low-power module; the portable means that the light source module is integrated with the near-infrared spectrum module and the Bluetooth low-power module. It is small in size, light in weight, and easy to carry; The fast scanning time is 2.88s/time.

The light source module has two halogen tungsten lamps; the working power of the halogen tungsten lamp is 1.4W, and it is placed at an angle of 40° horizontally; the scanning window size of the light source module is 5mm*5mm, which can effectively collect normal adult Middle finger of blood sugar.

The wavelength range of the near-infrared spectrum module is 900nm~1700nm, which can effectively cover the near-infrared spectrum region; the signal-to-noise ratio of the near-infrared spectrum module is 6000:1, the optical resolution is 10nm, and the scanning spectrum information is good.

The bluetooth low power module will automatically sleep if not used within 10s to save power; the wireless transmission is used for data transmission with a commercially available android development board (or android mobile phone) that supports bluetooth 4.0; the software write The input supports multiple individual blood glucose detection models; the analysis and prediction uses a specific individual blood glucose detection model for blood glucose detection; the individual blood glucose detection model can be self-optimized with the increase of detection data.

A rapid non-invasive blood sugar detection device, characterized in that: it can realize the rapid non-invasive blood sugar detection method, specifically including a blood sugar detection device and a blood sugar display device, which are connected via four screw holes located at the diagonal positions of the blood sugar display device;

In the blood glucose detection device, the light source module (1) is connected to the front end of the near infrared module (2); the end of the near infrared module (2) is connected to the Bluetooth low power consumption module (3); the light source module (1), the near infrared The infrared module (2) and the Bluetooth low-power module (3) are both placed inside the housing (4); a detection window (5) is left at the front end of the housing (4); the upper end of the housing (4) is installed There is an Android development board (7); the lower end of the housing (4) is connected to the handle (6); the handle (6) is equipped with a mobile power supply;

The blood glucose display device is an Android development board (7); the Android development board (7) includes a spectral curve display area (8) and a quantitative detection area (9).

The detection window (5) has a size of 1.0cm*1.0cm and is located at the center of the front end of the casing (4), which can effectively match the scanning window of the light source module; the casing (4) and the handle (6) pass through four The screw holes are connected; the handle (6) is a cylinder with a certain size of height and bottom circle diameter; a mobile power supply is built in the cylinder;

In the blood glucose display device, the upper half is a spectral curve display area (8), and the lower half is a quantitative detection area (9).

The beneficial effects of the present invention are as follows:

First, for the collection of near-infrared spectrum of blood sugar: the present invention uses a portable near-infrared spectrometer to obtain the spectrum of human blood sugar to achieve rapid non-invasive blood sugar measurement, which has the advantages of no stinging, no infection, no side effects, and short test time;

Second, for the transmission of blood glucose spectrum data: the present invention adopts Bluetooth Low Energy (BLE) wireless transmission technology to support the current Android mobile phone security application with Bluetooth 4.0 transmission, which is in line with the demand trend of the popular information age;

Third, non-invasive detection of blood sugar content: the present invention establishes a corresponding prediction model for a specific individual, which is different from the traditional non-invasive method that considers multiple factors. The detection method is simpler and more operable; it supports blood sugar levels of multiple individuals Prediction, and has data storage function, which can be used for optimization analysis of later prediction models and improve the accuracy of blood sugar detection.

Fourth, for the rapid non-invasive detection device of blood sugar: the present invention adopts a near-infrared spectrometer integrating a tungsten-halogen light source module, a Bluetooth low-power module and a near-infrared module. The non-invasive detection device for blood sugar has a simple structure design and is easy to operate; The Android development board or mobile phone with Bluetooth 4.0 can transmit the blood sugar data to the mobile device in real time, and can detect the blood sugar of the patient throughout the process, thereby improving the ability to monitor and protect the patient.

Description of drawings

Fig. 1 is a structural diagram of the experimental device of the present invention;

Fig. 2 is the top view of experimental device of the present invention;

In the figure: 1 light source module, 2 near-infrared module, 3 Bluetooth low energy module, 4 housing, 5 scanning window, 6 handle, 7 Android development board, 8 spectral curve area, 9 quantitative display area, 10 qualitative display area.

detailed description

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings and specific embodiments.

Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

Fig. 1 is a structural diagram of the experimental device of the present invention. According to Fig. 1, in the blood glucose detection device, the light source module is connected to the front end of the near-infrared module; the end of the near-infrared module is connected to the Bluetooth low power consumption module; The module and the Bluetooth low-power module are placed inside the housing; the front end of the housing has a detection window; the upper end of the housing is installed with an Android development board; the lower end of the housing is connected to the handle; Handle with built-in mobile power.

Fig. 2 is a top view of the experimental device of the present invention. According to Fig. 2, the blood glucose display device is an Android development board; the Android development board includes a spectral curve display area and a quantitative detection area.

Hold the handle of the blood glucose detection device with one hand, align the detection window of the blood glucose detection device with the middle finger of the human body, click the "scan" button on the interface of the blood glucose display device, wait for 2.88 seconds, and observe the blood glucose in the spectral curve display area The near-infrared spectrum curve image; click the "prediction" button on the interface of the blood glucose display device to view the blood glucose content.

In the description of this specification, references to the terms "one embodiment," "some embodiments," "exemplary embodiments," "example," "specific examples," or "some examples" are intended to mean that the implementation A specific feature, structure, material, or characteristic described by an embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although the embodiments of the present invention have been shown and described, those skilled in the art can understand that various changes, modifications, substitutions and modifications can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the invention is defined by the claims and their equivalents.

Claims (8)

1. A fast non-invasive blood glucose detection method, is characterized in that, comprises the following steps: Step 1, minimally invasive collection and detection of blood sugar levels: according to the time points before breakfast, before lunch, and before going to bed every day, for one week, use a conventional minimally invasive blood glucose meter to measure the blood sugar content of the sample by means of acupuncture blood collection, and obtain the conventional micro-glucose blood glucose meter. The blood glucose value measured by the blood glucose meter; Step 2, collection of near-infrared spectrum data of blood sugar: using the light source module as the signal source, the portable near-infrared spectrum module receives the diffuse reflectance spectrum of blood sugar, performs fast and non-invasive blood sugar spectrum collection, and obtains near-infrared spectrum data of blood sugar; Step 3, optimization analysis of the blood glucose detection model: combining the collected near-infrared spectrum data of blood glucose with the blood glucose value measured by the conventional minimally invasive blood glucose meter, and combining the multiple linear regression method to establish the blood glucose detection model; Step 4, non-invasive detection of blood sugar content: connect to the Android development board supporting Bluetooth 4.0 through the Bluetooth low-power module, and wirelessly transmit the near-infrared spectrum data of blood sugar; Individuals undergo non-invasive blood glucose testing. 2. A rapid non-invasive blood sugar detection method according to claim 1, characterized in that, the time points before breakfast, before lunch, and before going to bed in the first step are universally applicable to the crowd and conform to the daily work and rest rules of the public; The one-week duration is specifically to collect 21 blood sugar content values for subsequent establishment of a blood sugar detection model; the acupuncture blood collection method is specifically to collect a drop of blood from the middle finger, and there is no obvious pain in the human body. 3. A fast non-invasive blood glucose detection method according to claim 1, characterized in that: the light source module is integrated with the near-infrared spectrum module and the Bluetooth low power consumption module; The integration of the spectrum module and the Bluetooth low-power module is small in size, light in weight, and easy to carry; the fast scanning time is 2.88s/time. 4. A fast non-invasive blood sugar detection method according to claim 1, characterized in that: the light source module has two halogen tungsten lamps; the working power of the halogen tungsten lamps is 1.4W, and the horizontal angle is 40° Placement; the scanning window size of the light source module is 5mm*5mm, which can effectively collect the blood sugar of the middle finger of normal adults. 5. A fast non-invasive blood sugar detection method according to claim 1, characterized in that: the wavelength range of the near-infrared spectrum module is 900nm~1700nm, which can effectively cover the near-infrared spectrum region; the near-infrared spectrum module's The signal-to-noise ratio is 6000:1, the optical resolution is 10nm, and the scanning spectral information is good. 6. A fast non-invasive blood glucose detection method according to claim 1, characterized in that: the Bluetooth low energy module will automatically sleep if not used within 10s to save power; the wireless transmission is used to support The commercially available Android development board or Android mobile phone of Bluetooth 4.0 performs data transmission; the software is written to support a plurality of individual blood glucose detection models; the analysis and prediction adopts a specific individual blood glucose detection model for blood glucose detection; With the increase of detection data, the individual blood glucose detection model can be optimized by itself. 7. A rapid non-invasive blood sugar detection device, characterized in that: it can realize the rapid non-invasive blood sugar detection method as claimed in claim 1, specifically comprising a blood sugar detection device and a blood sugar display device, through 4 diagonal positions of the blood glucose display device connected by screw holes; In the blood glucose detection device, the light source module (1) is connected to the front end of the near infrared module (2); the end of the near infrared module (2) is connected to the Bluetooth low power consumption module (3); the light source module (1), the near infrared The infrared module (2) and the Bluetooth low-power module (3) are both placed inside the housing (4); a detection window (5) is left at the front end of the housing (4); the upper end of the housing (4) is installed There is an Android development board (7); the lower end of the housing (4) is connected to the handle (6); the handle (6) is equipped with a mobile power supply; The blood glucose display device is an Android development board (7); the Android development board (7) includes a spectral curve display area (8) and a quantitative detection area (9). 8. A rapid non-invasive blood glucose detection device according to claim 7, characterized in that: the detection window (5) has a size of 1.0cm*1.0cm, is located at the center of the front end of the casing (4), and can effectively match The scanning window of the light source module; the housing (4) is connected to the handle (6) via 4 screw holes; the handle (6) is a cylinder with a certain size of height and bottom circle diameter; the cylinder has built-in mobile power; In the blood glucose display device, the upper half is a spectral curve display area (8), and the lower half is a quantitative detection area (9).