CN107041921A - A kind of composition for being used to treat the diseases such as hypoplasia of uterus, irregular menstruation - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition, in parts by mass, the bulk drug proportioning of the active constituents of medicine of the Chinese medicine composition is：100~500 parts of motherwort, 20~40 parts of Radix Angelicae Sinensis, interrupted 15~20 parts, 10~20 parts of the bark of eucommia, 10~20 parts of Chinese yam, 40~50 parts of donkey-hide gelatin.The pharmaceutical composition has warm kidney blood-nourishing, blood-nourishing and battalion, and effect promoting blood circulation and removing blood stasis goes for the symptoms such as hypoplasia of uterus, irregular menstruation, amenorrhoea.

Description

A composition for treating uterine dysplasia, irregular menstruation and other diseases

technical field

The invention relates to the field of traditional Chinese medicine, in particular to a composition for treating uterine dysplasia, irregular menstruation and the like.

Background technique

Menstrual disease is a common disease in gynecology, such as early menstruation, missed menstruation, dysmenorrhea, amenorrhea, and metrorrhagia. The etiology of menstrual disease has two aspects: exogenous pathogenic factors and internal injuries. Exogenous pathogenic factors are mainly cold, heat, and dampness. When these exogenous pathogens invade the human body, they will affect the circulation of qi and blood in the body, resulting in abnormal circulation of qi and blood in weak women, which in turn will affect the menstrual cycle. , Ren Ermai, resulting in irregular menstruation. Internal injuries are caused by worries, thoughts, sorrows, and shocks. These factors often cause Qi and blood disorders, and the Chong and Ren channels are damaged, so menstrual diseases occur. In addition, improper diet can also affect women's menstruation, such as improper diet, which can damage the temper; overeating spicy food can cause spleen and stomach to accumulate heat; damage. Clinically, menstrual disorders caused by other acute and chronic diseases are also common.

Motherwort, also known as: Lily, Chiwei, Kuncao, Jiuzhonglou, Mica Grass, Senti, is a plant of the Lamiaceae and the genus Leonurus, which blooms in summer. Its dry aerial part is commonly used in traditional Chinese medicine, and it is produced in most parts of China. It is used raw or boiled for ointment. The annual or biennial herbs are distributed in most parts of the country, and are born in wild lands, fields, grasslands, etc. It is picked in summer when the lush flowers are not in full bloom. It tastes bitter and cool. It can promote blood circulation, remove silt, regulate menstruation, and eliminate water. Next, hematuria, diarrhea, carbuncle sores. Motherwort has diuretic, swelling, and uterine contraction effects, and it is an important medicine used by doctors of all ages to treat gynecological diseases.

In order to treat symptoms such as uterine dysplasia, irregular menstruation, and amenorrhea, it is very important to invent a Chinese medicine formula with remarkable effects.

Contents of the invention

The purpose of the present invention is to disclose the formula of a traditional Chinese medicine composition with remarkable effect.

The technical scheme that the present invention takes is:

A traditional Chinese medicine composition, the active ingredients of which are Motherwort, Angelica, Dipsacus, Eucommia, Chinese Yam and Ejiao.

Preferably, in terms of parts by mass, the raw material ratio of the active ingredients of the medicine is: 100-500 parts of motherwort, 20-40 parts of angelica, 15-20 parts of intermittent, 10-20 parts of Eucommia, 10-20 parts of yam, donkey-hide gelatin 40-50 copies.

Further preferably, in terms of parts by mass, the raw material ratio of the active ingredients is: 250 parts of Motherwort, 30 parts of Angelica sinensis, 18 parts of Duzhong, 15 parts of Eucommia ulmoides, 15 parts of Chinese yam, and 45 parts of donkey-hide gelatin.

Preferably, the traditional Chinese medicine composition is an oral agent.

Preferably, the traditional Chinese medicine composition formula can prepare medicines for treating uterine dysplasia, irregular menstruation and amenorrhea.

A method for preparing a medicine for treating uterine dysplasia, irregular menstruation, and amenorrhea, which comprises the steps of: taking 100-500 parts of motherwort, 20-40 parts of angelica, 15-20 parts of intermittent, and 10-20 parts of Eucommia 10-20 parts of yam, 40-50 parts of donkey-hide gelatin, mix well, add 800-1000 parts of refined honey while hot, stir evenly at high speed, make pills, and get it.

The beneficial effects of the invention are: the pharmaceutical composition can inhibit the uterine contraction caused by oxytocin in vivo, and can promote endometrial hyperplasia at the same time. It can be used to treat symptoms such as uterine dysplasia, irregular menstruation, and amenorrhea.

detailed description

Example 1

Take 250g of Motherwort, 30g of Angelica, 18g of Dipsacus, 15g of Eucommia, 15g of Chinese Yam, and 45g of Ejiao, grind them finely, pass through an 80-100 mesh sieve, mix well, add 900g of refined honey while it is hot, stir evenly at high speed, make pellets, and make each Pill 3g.

Example 2

Take 100g of Motherwort, 40g of Angelica, 20g of Dipsacus, 20g of Eucommia, 20g of Chinese Yam, and 50g of Ejiao, grind them finely, pass through a 80-100 mesh sieve, mix well, add 800g of refined honey while it is hot, stir evenly at high speed, make pellets, and make each Pill 3g.

Example 3

Take 200g of Motherwort, 40g of Angelica, 20g of Dipsacus, 20g of Eucommia, 15g of Chinese Yam, and 40g of Ejiao, grind them finely, pass through an 80-100 mesh sieve, mix well, add 1000g of refined honey while it is hot, stir evenly at high speed, make pills, and make each Pill 3g.

Example 4

Take 300g of Motherwort, 20g of Angelica, 15g of Dipsacus, 10g of Eucommia, 10g of Chinese Yam, and 50g of Ejiao, grind them finely, pass through an 80-100 mesh sieve, mix well, add 900g of refined honey while it is hot, stir evenly at high speed, make pellets, and make each Pill 3g.

Example 5

Take 500g of Motherwort, 20g of Angelica, 15g of Dipsacus, 10g of Eucommia, 10g of Chinese Yam, and 40g of Ejiao, grind them finely, pass through a 80-100 mesh sieve, mix well, add 800g of refined honey while it is hot, stir evenly at high speed, make pellets, and make each Pill 3g.

Experimental example

1. Effects on mouse uterus and ovary development

50 female mice, body weight (11±1) g, were randomly divided into 5 groups, normal saline group, diethylstilbestrol group, modified Yimu pill group (3.6, 2.4, 1.2g/Kg), modified Yimu pill It is the formula of Example 1. Except for the subcutaneous injection of diethylstilbestrol group, all other groups were intragastrically administered at a dose of 0.0012 g/mL. The administration was continued for 14 days. On the 15th day, the animals were weighed and sacrificed, and the uterus was dissected. and ovary, peel off the connective tissue around it, weigh it with an electronic balance, and convert it into organ coefficient, the results are shown in Table 1

Table 1 The effect of Jiawei Yimu Pill on mouse uterus development (x±s, n=10)

Note: Compared with the control group ①P<0.05, ②P<0.01 (the same below)

The results showed that the high-dose and medium-dose groups of Jiawei Yimu Pill could significantly increase the weight of the mouse uterus, but had no effect on the weight gain of the ovary. 2 Effects on the writhing response of rats induced by oxytocin

50 female rats, body weight (200±20) g, were randomly divided into 5 groups, and continuously subcutaneously injected diethylstilbestrol for 10 days (0.8 mg/rat on the 1st and 10th day, and 0.4 mg/rat every day for the rest) On the 5th day after the injection of diethylstilbestrol, the drug was given by intragastric administration for 7 days continuously (aspirin was given for 3 days). 24 hours after the last dose of diethylstilbestrol, the test drug was administered once again, and the ip contraction was performed 40 minutes later. Uterine 2 μ/rat, observe the number of writhing reactions in rats within 30 minutes (abdominal contraction and indentation of rats, trunk and hind limbs stretch, arms and side limbs inward rotation, which are indicators of uterine contraction or dysmenorrhea), the results are shown in the table 2.

Table 2 Effect of Jiawei Yimu Pills on the Writhing Response of Mice Caused by Oxytocin (x±s, n=10)

The results showed that the high-dose and medium-dose groups of Jiawei Yimu Pill could significantly reduce the number of writhing reactions in mice.

3. Effects on isolated rat uteri

Rats 120-200g, female, subcutaneously inject diethylstilbestrol at 0.2mg/100g body weight 24 hours before the experiment to promote the animal to be in estrus, so as to improve the sensitivity of the uterus to the drug. Before the start of the experiment, the animals were killed, and the 2 cm long uterus was cut and fixed in a Maxwellian bath filled with uterine nutrient solution (15 mL). 1g (Uterine muscle tension can be directly measured from the computer), and O ₂ is continuously injected into the Maxwell bath at a rate of 1 to 2 bubbles per second. After the uterus was stabilized, the drug was added, and the drug was washed three times with nutrient solution every time the drug was changed. The drug concentration was the final concentration in the bath. Observe and record the highest muscle tension and number of contractions of the uterus within 10 minutes after administration, the results are shown in Table 3

Table 3 The effect of Jiawei Yimu Pill on rat isolated uterine muscle tension (x±s, n=10)

The results show that Jiawei Yimu Pill can significantly enhance the contraction of isolated rat uterus, and there is a certain dose-effect relationship, the contraction force is enhanced and the contraction frequency is accelerated as the dose increases.

4. Effects on contraction of rat isolated uterine smooth muscle induced by oxytocin

The experimental method is the same as 3. After the uterine activity is stable, add 0.05 μg (the final concentration of the bath is 0.003 μg/mL) oxytocin from the top of the bath, and the uterine smooth muscle begins to contract, and can be stable at the highest point for 30 minutes. Added Jiawei Yimu Pills to observe the uterine contraction, the results are shown in Table 4

Table 4 Effects of Modified Yimu Pills on contraction of rat isolated uterine smooth muscle induced by oxytocin (x±s, n=10)

The results showed that the tension of uterine muscle decreased after adding Jiawei Yimu Pills, and there were different degrees of inhibition.

5. Clinical research data

Treatment group: Jiawei Yimu Pills, drug composition: Leonurus 250g, Angelica 30g, Dipsacus 18g, Eucommia 15g, Chinese yam 15g, Ejiao 45g, mixed with water, 3g/pill, 2-3 times a day, 2 pills each time. Control group 1: motherwort granules, 15g/packet, 2 times a day, 1 packet each time.

Control group 2: Bazhen Yimu Pills (Da Miwan), 9g/pill, 2 times a day, 1 pill each time.

Criteria for inclusion of cases: ①Patients diagnosed with irregular menstruation. ②Aged between 25 and 45 years old. ③ It is confirmed by the doctor in charge that during the trial period, if adverse reactions occur, it will not affect the patient's treatment. ④ Sign the informed consent form. A total of 186 case report forms were received by the end of this clinical study. There were 62 cases in the test group, 62 cases in the control group 1, and 62 cases in the control group 2, all of whom were outpatients. Western medicine diagnosis is irregular menstruation, and TCM syndrome differentiation belongs to Qi stagnation and blood stasis syndrome.

Changes in menstrual cycle, quantity, color, quality, duration and related syndromes are judged by changes in clinical symptoms as quantitative indicators. The results are as follows:

Comparing the curative effects of the three medicines on symptoms such as abdominal pain, fatigue, and dysmenorrhea, Jiawei Yimu Pills has obvious advantages over the other two, and its symptom disappearance rate is more than 10% higher.

Claims (6)

1. a kind of Chinese medicine composition, it is characterised in that the active constituents of medicine of the Chinese medicine composition is motherwort, Radix Angelicae Sinensis, continued The disconnected, bark of eucommia, Chinese yam, donkey-hide gelatin.

2. Chinese medicine composition according to claim 1, it is characterised in that in parts by mass, the active constituents of medicine Bulk drug is matched：100~500 parts of motherwort, 20~40 parts of Radix Angelicae Sinensis, interrupted 15~20 parts, 10~20 parts of the bark of eucommia, Chinese yam 10~ 20 parts, 40~50 parts of donkey-hide gelatin.

3. Chinese medicine composition according to claim 1, it is characterised in that in parts by mass, the active constituents of medicine Bulk drug is matched：250 parts of motherwort, 30 parts of Radix Angelicae Sinensis, interrupted 18 parts, 15 parts of the bark of eucommia, 15 parts of Chinese yam, 45 parts of donkey-hide gelatin.

4. the Chinese medicine composition according to claims 1 to 3 any one, it is characterised in that described Chinese medicine composition is Oral agents.

5. the Chinese medicine composition according to claims 1 to 3 any one is preparing treatment hypoplasia of uterus, menstruation not Application in tune, amenorrhoea medicine.

6. a kind of prepare treatment hypoplasia of uterus, irregular menstruation, the method for amenorrhoea medicine, its step is：In parts by mass, take 100~500 parts of motherwort, 20~40 parts of Radix Angelicae Sinensis, interrupted 15~20 parts, 10~20 parts of the bark of eucommia, 10~20 parts of Chinese yam, donkey-hide gelatin 40~ 50 parts, it is sufficiently mixed uniformly, 800~1000 parts of refined honey is added while hot, high-speed stirred is uniform, and pill is produced.