CN107028941A - A kind of sleep aid and preparation method thereof and application method, atomizer - Google Patents
A kind of sleep aid and preparation method thereof and application method, atomizer Download PDFInfo
- Publication number
- CN107028941A CN107028941A CN201710368112.6A CN201710368112A CN107028941A CN 107028941 A CN107028941 A CN 107028941A CN 201710368112 A CN201710368112 A CN 201710368112A CN 107028941 A CN107028941 A CN 107028941A
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- Prior art keywords
- sleep aid
- parts
- epiphysin
- sleep
- volatilizer
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- 230000007958 sleep Effects 0.000 title claims abstract description 68
- 238000000034 method Methods 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 230000002101 lytic effect Effects 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000010438 heat treatment Methods 0.000 claims abstract description 13
- 238000000889 atomisation Methods 0.000 claims abstract description 9
- 235000011187 glycerol Nutrition 0.000 claims abstract description 7
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical group CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 9
- 239000004480 active ingredient Substances 0.000 abstract description 8
- 210000004072 lung Anatomy 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 4
- 230000033764 rhythmic process Effects 0.000 abstract description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract description 3
- 239000003163 gonadal steroid hormone Substances 0.000 abstract description 3
- 210000004560 pineal gland Anatomy 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 10
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 6
- 229960003987 melatonin Drugs 0.000 description 6
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 6
- 230000000147 hypnotic effect Effects 0.000 description 5
- 239000006184 cosolvent Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000008667 sleep stage Effects 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 2
- 230000005059 dormancy Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000004461 rapid eye movement Effects 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003571 electronic cigarette Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- UYXAWHWODHRRMR-UHFFFAOYSA-N hexobarbital Chemical compound O=C1N(C)C(=O)NC(=O)C1(C)C1=CCCCC1 UYXAWHWODHRRMR-UHFFFAOYSA-N 0.000 description 1
- 229960002456 hexobarbital Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000000803 paradoxical effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000013707 sensory perception of sound Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 230000004617 sleep duration Effects 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 230000037322 slow-wave sleep Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of sleep aid and preparation method thereof and application method, atomizer, the sleep aid count by weight including：3 12 parts of epiphysin；25 75 parts of lytic agent；25 75 parts of volatilizer.The present invention is by by epiphysin, glycerine and mixed with propylene glycol, form mixture, when using, only need a heating component, compact portable product can be flexibly designed to, it is easy to carry, when using, other supplementary means need not be borrowed, only need to the gas sucked after sleep aid atomization, it is easy to use, active ingredient is atomized, lung can be directly sucked in, directly absorbed by lung capillaries and enter blood, it is rapid-action, active ingredient is epiphysin, it is a kind of OTC raw material, it is a kind of inherently exist in human body the primary sex hormone secreted by pineal body to adjust the sleep rhythm of human body, it can be metabolized by human body natural, safely and effectively.
Description
Technical field
The present invention relates to sleep aid, more specifically refer to a kind of sleep aid and preparation method thereof and application method, atomization
Device.
Background technology
With the quickening pace of modern life, people are chronically in the state of high pressure, and spirit is in high-strung state, nothing
Method is in relaxation state, cannot propagate into stable sleep stage.Therefore, insomnia problem has become current people face now
The universal health problem faced, the compatriots for having sixty percent according to investigations are perplexed by difficulty falling asleep, largely need to use sleeping product
Sleep stage can just be entered.
Current sleeping product is in the majority to drink type product and tablet class product, drinks type product including health preserving tea etc.,
Tablet class product is that hypnotic is in the majority, still, and above-mentioned sleeping product is inconvenient when carrying, because part needs hydrous water
It could be drunk Deng liquid, therefore, in-convenience in use, for different people, assimilation effect is inconsistent, can cause to deposit
In the phenomenon of slowly effect, and the sleeping product such as similar hypnotic, there is certain infringement to body.
Therefore, it is necessary to design a kind of sleep aid, easy to carry, easy to use and instant effect is realized, safely and effectively.
The content of the invention
It is an object of the invention to overcome the defect of prior art there is provided a kind of sleep aid and preparation method thereof and use
Method, atomizer.
To achieve the above object, the present invention uses following technical scheme：A kind of sleep aid, by weight meter include：
3-12 parts of epiphysin；
25-75 parts of lytic agent；
25-75 parts of volatilizer.
Its further technical scheme is：A kind of sleep aid count by weight including：
4-11 parts of epiphysin；
23-73 parts of lytic agent；
23-73 parts of volatilizer.
Its further technical scheme is：A kind of sleep aid count by weight including：
5-10 parts of epiphysin；
30-70 parts of lytic agent；
30-70 parts of volatilizer.
Its further technical scheme is：The lytic agent is propane diols.
Its further technical scheme is：The volatilizer is glycerine.
Its further technical scheme is：A kind of sleep aid is counted by weight also to be included：
0.5-1.5 parts of essence.
Its further technical scheme is：A kind of sleep aid is counted by weight also to be included：
1 part of essence.
Present invention also offers a kind of preparation method of sleep aid, methods described includes：
The epiphysin, lytic agent, volatilizer and essence are mixed, mixture is formed；
The mixture is stirred, sleep aid is obtained.
Present invention also offers a kind of application method of sleep aid, the application method includes：
In use, being heated to sleep aid, atomization gas is volatilized.
Present invention also offers atomizer, including housing and the heating member in housing, it is provided with and holds in the housing
Receive chamber, the sleep aid is placed in the accommodating chamber, and the heating member is heated to the sleep aid.
Compared with the prior art, the invention has the advantages that：A kind of sleep aid of the present invention, by by epiphysin, sweet
Oil and mixed with propylene glycol, form mixture, in use, only need a heating component, can flexibly be designed to it is compact just
The product taken, it is easy to carry, in use, other supplementary means need not be borrowed, it is only necessary to the gas sucked after sleep aid atomization
Body, it is easy to use, active ingredient is atomized, lung can be directly sucked in, directly absorbed and entered by lung capillaries
Blood, rapid-action, active ingredient is epiphysin, is a kind of OTC raw material, is inherently present in a kind of human body by pine
The primary sex hormone of fruit body secretion adjusts the sleep rhythm of human body, can be metabolized by human body natural, safely and effectively.
With reference to specific embodiment, the invention will be further described.
Embodiment
In order to more fully understand the technology contents of the present invention, with reference to specific embodiment to technical scheme
It is further described and illustrates, but is not limited to this.
A kind of sleep aid that the present embodiment is provided, can be used in the sleeping product with heating arrangement, realize and carry
It is convenient, easy to use and instant effect, safely and effectively.
A kind of sleep aid, by weight meter include：
3-12 parts of epiphysin；
25-75 parts of lytic agent；
25-75 parts of volatilizer.
Wherein epiphysin is formulated functional elements for this, plays a part of sleeping.Holmes have studied urging for melatonin
Dormancy is acted on and the influence to neurochemistry, and rat is given after 10mg/kg BW melatonins, time for falling asleep is detected with EEG, with clothes
Compared before medicine, shorten half, the awakening time also substantially shortens, and slow wave sleep, paradoxical sleep are obviously prolonged and easily waken up；
2.5mg/kg BW are given, lower slightly, the similar hypnotic effect of degree is obtained.The melatonin of any dosage is marked all without change
Quasi- EEC models and the normal sleep rule of interference.Peritonaeum give mouse melatonin 25mg/kg BW syngignoscism with
The effect of 100mg/kg BW (peritonaeum) hexobarbital (somnifacient) is similar.
Dollins etc. (1994) carries out hypnotic effect to 20 young healthy volunteers with low dosage melatonin and ground
Study carefully, volunteer is in the morning 11：After 45 oral 0.1~10mg melatonins, its serum-concentration reaches normal person's night mean concentration
Level；0.1st, each dosage groups such as 0.3,1.0 and 10.0 make subject oral cavity temperature drop, time for falling asleep substantially shorten, sleep
Duration is obviously prolonged, energy declines, sense of fatigue increases, Hypoemotivity, to the Wilkinson sense of hearings awakening experiment reaction just
True rate declines.
Waldhauser etc. (1990) also carries out oral 80mg melatonins hypnotic effect to 20 young healthy volunteers
Research.It was observed that serum drug level reaches peak value (average out to 25817pg/mL) after medication 1h, it is significantly higher than normal human blood
Clear concentration, sleeps preceding waking hours, time for falling asleep and shortens, sleep quality improves, and number of times of awakening in sleep is significantly reduced, and is slept
Dormancy structural adjustment, it is shallow to sleep stage shortening, deep sleep stages extension, threshold wake-up value decline in the next morning.Irina etc. (1995) 18,
20th, 21 when give volunteer oral 0.3mg and 1.0mg melatonin, can make sleep and enter sleep the second stage time contracting
It is short, but REM (Rapid eye movements, the rapid eye movement) phases are not influenceed, show that melatonin helps to improve insomnia.
Epiphysin is a kind of OTC raw material, be inherently exist in a kind of human body by pineal body secrete it is original
Hormone adjusts the sleep rhythm of human body, can be metabolized by human body natural so that whole sleeping process is more safe and effective.
Further, a kind of above-mentioned sleep aid count by weight including：
4-11 parts of epiphysin；
23-73 parts of lytic agent；
23-73 parts of volatilizer.
It is furthermore preferred that a kind of above-mentioned sleep aid count by weight including：
5-10 parts of epiphysin；
30-70 parts of lytic agent；
30-70 parts of volatilizer.
In the present embodiment, lytic agent is propane diols；The volatilizer is glycerine.
In other embodiment, above-mentioned lytic agent can be other liquid such as water.
In other embodiment, above-mentioned volatilizer can be alcohol.
Above-mentioned propane diols is lytic agent, is responsible for dissolving epiphysin and essence；Glycerine is volatilizer, is responsible for helping other
Composition is evaporated, and is easy to absorption of human body.
In order to adjust the taste of whole sleep aid, a kind of above-mentioned sleep aid is counted by weight also to be included：
0.5-1.5 parts of essence.
Further, a kind of above-mentioned sleep aid is counted also include by weight：
0.8-1.2 parts of essence.
Most preferably, a kind of above-mentioned sleep aid is counted also include by weight：
1 part of essence.
Essence is flavor enhancement, increases products taste, further the interest of lifting product and medication when avoiding the people from using
Association.
Above-mentioned epiphysin is main composition, and general sleeping can be reached when human body takes in 1mg epiphysin compositions
Effect；Regulation sleep biological clock effect can be reached during intake 3mg epiphysin compositions；Can be with when taking in 10mg epiphysin compositions
Reach the effect of regulation severe insomnia.
Propane diols is the lytic agent of active ingredient epiphysin, can reach the dissolving ratio of epiphysin in 30 parts of ratio
To 5%；In 70 parts of ratio the dissolving ratio of epiphysin can be made to reach 10%.
In addition, glycerine is volatilizer, the corresponding ratio increase of propane diols can be caused in 30 parts of ratio, so that
Epiphysin dissolving ratio reaches 10%, and the steaming effect now produced is poor, only a small amount of attenuated vapor generation；At 70 parts
The corresponding ratio of propane diols can be caused to reduce during ratio, so that epiphysin dissolving ratio reaches 5%, the steaming now produced
Vapour effect preferably, has a large amount of steam to generate.
And essence is mainly flavor enhancement, the taste of this formula can be changed as needed.
For active ingredient epiphysin：Bioavilability is 30-50%；The organ of body metabolism epiphysin is liver
It is dirty；The biological half-life of epiphysin is 35-50 minutes；The organ of body discharges epiphysin is kidney.
Further, a kind of above-mentioned sleep aid also includes cosolvent, and the cosolvent is used to lift the molten of epiphysin
Xie Du.
, can also be without using cosolvent in other embodiment, can be with when being necessary to be lifted the solubility of epiphysin
Selection addition cosolvent.
A kind of above-mentioned sleep aid, by by epiphysin, glycerine and mixed with propylene glycol, forming mixture, in use,
A heating component is only needed, compact portable product can be flexibly designed to, it is easy to carry, in use, need not borrow
Other supplementary means, it is only necessary to the gas sucked after sleep aid atomization, it is easy to use, active ingredient is atomized, can be with
Lung is directly sucked in, is directly absorbed by lung capillaries and enters blood, rapid-action, active ingredient is epiphysin, is a kind of
OTC raw material, is a kind of inherently exist in human body the primary sex hormone secreted by pineal body to adjust the sleep of human body
The rhythm and pace of moving things, can be metabolized, safely and effectively by human body natural.
In addition, the present embodiment additionally provides a kind of preparation method of sleep aid, this method includes：
The epiphysin, lytic agent, volatilizer and essence are mixed, mixture is formed；
The mixture is stirred, sleep aid is obtained.
In use, being heated to sleep aid, atomization gas is volatilized.
When being stirred to mixture, optimal state is that stirring to liquid is in clear state.
The present embodiment additionally provides a kind of application method of sleep aid, and the application method includes：
In use, being heated to sleep aid, atomization gas is volatilized.
The present embodiment is additionally provided to be provided with atomizer, including housing and the heating member in housing, the housing
Accommodating chamber, the sleep aid is placed in the accommodating chamber, and the heating member is heated to the sleep aid.
The atomizer can be electronic cigarette, and heating member is heating plate or heating tube.
Certainly, above-mentioned atomizer can also be that atomization mosquito-repellent incense etc. can be with the equipment of atomized liquid.
The above-mentioned technology contents that the present invention is only further illustrated with embodiment, in order to which reader is easier to understand, but not
Represent embodiments of the present invention and be only limitted to this, any technology done according to the present invention extends or recreated, by the present invention's
Protection.Protection scope of the present invention is defined by claims.
Claims (10)
1. a kind of sleep aid, it is characterised in that meter includes by weight：
3-12 parts of epiphysin；
25-75 parts of lytic agent；
25-75 parts of volatilizer.
2. a kind of sleep aid according to claim 1, it is characterised in that a kind of sleep aid counts bag by weight
Include：
4-11 parts of epiphysin；
23-73 parts of lytic agent；
23-73 parts of volatilizer.
3. a kind of sleep aid according to claim 2, it is characterised in that a kind of sleep aid counts bag by weight
Include：
5-10 parts of epiphysin；
30-70 parts of lytic agent；
30-70 parts of volatilizer.
4. a kind of sleep aid according to any one of claims 1 to 3, it is characterised in that the lytic agent is propane diols.
5. a kind of sleep aid according to claim 4, it is characterised in that the volatilizer is glycerine.
6. a kind of sleep aid according to claim 1, it is characterised in that a kind of sleep aid is counted by weight also to be wrapped
Include：
0.5-1.5 parts of essence.
7. a kind of sleep aid according to claim 6, it is characterised in that a kind of sleep aid is counted by weight also to be wrapped
Include：
1 part of essence.
8. a kind of preparation method of sleep aid, it is characterised in that methods described includes：
The epiphysin, lytic agent, volatilizer and essence are mixed, mixture is formed；
The mixture is stirred, sleep aid is obtained.
9. a kind of application method of sleep aid, it is characterised in that the application method includes：
In use, being heated to sleep aid, atomization gas is volatilized.
10. accommodating chamber is provided with atomizer, it is characterised in that the heating member including housing and in housing, the housing,
The sleep aid is placed in the accommodating chamber, and the heating member is heated to the sleep aid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710368112.6A CN107028941A (en) | 2017-05-23 | 2017-05-23 | A kind of sleep aid and preparation method thereof and application method, atomizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710368112.6A CN107028941A (en) | 2017-05-23 | 2017-05-23 | A kind of sleep aid and preparation method thereof and application method, atomizer |
Publications (1)
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| CN107028941A true CN107028941A (en) | 2017-08-11 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710368112.6A Pending CN107028941A (en) | 2017-05-23 | 2017-05-23 | A kind of sleep aid and preparation method thereof and application method, atomizer |
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| Country | Link |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108420121A (en) * | 2018-05-29 | 2018-08-21 | 云南养瑞科技集团有限公司 | It is a kind of to have effects that improve tobacco juice for electronic smoke of sleep and preparation method thereof |
| CN110495631A (en) * | 2019-09-12 | 2019-11-26 | 深圳雾芯科技有限公司 | Electronic cigarette liquid |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969814A (en) * | 2005-11-24 | 2007-05-30 | 中国人民解放军军事医学科学院毒物药物研究所 | Nasal administered preparation of melatonin |
| CN101966167A (en) * | 2010-09-16 | 2011-02-09 | 杭州海王生物工程有限公司 | Melatonin soft capsules and preparation method thereof |
| TW201330849A (en) * | 2012-01-20 | 2013-08-01 | Renascence Therapeutics Ltd | Pharmaceutical compositions for intranasal administration of melatonin |
-
2017
- 2017-05-23 CN CN201710368112.6A patent/CN107028941A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969814A (en) * | 2005-11-24 | 2007-05-30 | 中国人民解放军军事医学科学院毒物药物研究所 | Nasal administered preparation of melatonin |
| CN101966167A (en) * | 2010-09-16 | 2011-02-09 | 杭州海王生物工程有限公司 | Melatonin soft capsules and preparation method thereof |
| TW201330849A (en) * | 2012-01-20 | 2013-08-01 | Renascence Therapeutics Ltd | Pharmaceutical compositions for intranasal administration of melatonin |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108420121A (en) * | 2018-05-29 | 2018-08-21 | 云南养瑞科技集团有限公司 | It is a kind of to have effects that improve tobacco juice for electronic smoke of sleep and preparation method thereof |
| CN110495631A (en) * | 2019-09-12 | 2019-11-26 | 深圳雾芯科技有限公司 | Electronic cigarette liquid |
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