CN107028774B - Heat stable suspension cosmetic composition - Google Patents
Heat stable suspension cosmetic composition Download PDFInfo
- Publication number
- CN107028774B CN107028774B CN201610860585.3A CN201610860585A CN107028774B CN 107028774 B CN107028774 B CN 107028774B CN 201610860585 A CN201610860585 A CN 201610860585A CN 107028774 B CN107028774 B CN 107028774B
- Authority
- CN
- China
- Prior art keywords
- cosmetic composition
- solubilizer
- suspension
- nonionic surfactant
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 62
- 239000000725 suspension Substances 0.000 title claims abstract description 46
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 239000002904 solvent Substances 0.000 claims abstract description 28
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 23
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 claims abstract description 12
- -1 sorbitan ester Chemical class 0.000 claims description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 150000003505 terpenes Chemical class 0.000 claims description 8
- 235000007586 terpenes Nutrition 0.000 claims description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 7
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims description 6
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 claims description 3
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims description 3
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims description 3
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims description 3
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims description 3
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims description 3
- 239000005792 Geraniol Substances 0.000 claims description 3
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 claims description 3
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 claims description 3
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 claims description 3
- 229930002886 farnesol Natural products 0.000 claims description 3
- 229940043259 farnesol Drugs 0.000 claims description 3
- 229940113087 geraniol Drugs 0.000 claims description 3
- 229930007744 linalool Natural products 0.000 claims description 3
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 claims description 3
- 229940116411 terpineol Drugs 0.000 claims description 3
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 239000000693 micelle Substances 0.000 abstract description 24
- 230000000052 comparative effect Effects 0.000 description 15
- 239000006210 lotion Substances 0.000 description 15
- 239000004359 castor oil Substances 0.000 description 12
- 235000019438 castor oil Nutrition 0.000 description 12
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 12
- 239000000126 substance Substances 0.000 description 10
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 9
- 239000004698 Polyethylene Substances 0.000 description 9
- 229920000573 polyethylene Polymers 0.000 description 9
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 9
- 239000004094 surface-active agent Substances 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 125000001165 hydrophobic group Chemical group 0.000 description 4
- LYRFLYHAGKPMFH-UHFFFAOYSA-N octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(N)=O LYRFLYHAGKPMFH-UHFFFAOYSA-N 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 229920001214 Polysorbate 60 Polymers 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 3
- 229940049964 oleate Drugs 0.000 description 3
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KWVPFECTOKLOBL-KTKRTIGZSA-N 2-[(z)-octadec-9-enoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCO KWVPFECTOKLOBL-KTKRTIGZSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229920002651 Polysorbate 85 Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 229940073669 ceteareth 20 Drugs 0.000 description 2
- 229940056318 ceteth-20 Drugs 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 229940071160 cocoate Drugs 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 2
- 229950008882 polysorbate Drugs 0.000 description 2
- 229940113124 polysorbate 60 Drugs 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229940113171 polysorbate 85 Drugs 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 229940057429 sorbitan isostearate Drugs 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 229940037312 stearamide Drugs 0.000 description 2
- 229940100459 steareth-20 Drugs 0.000 description 2
- 229940100458 steareth-21 Drugs 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- ZITBHNVGLSVXEF-UHFFFAOYSA-N 2-[2-(16-methylheptadecoxy)ethoxy]ethanol Chemical compound CC(C)CCCCCCCCCCCCCCCOCCOCCO ZITBHNVGLSVXEF-UHFFFAOYSA-N 0.000 description 1
- MGYUQZIGNZFZJS-KTKRTIGZSA-N 2-[2-[(z)-octadec-9-enoxy]ethoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCO MGYUQZIGNZFZJS-KTKRTIGZSA-N 0.000 description 1
- WVCHIGAIXREVNS-UHFFFAOYSA-N 2-hydroxy-1,4-naphthoquinone Chemical compound C1=CC=C2C(O)=CC(=O)C(=O)C2=C1 WVCHIGAIXREVNS-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 description 1
- PSIDAWVKSCOUEN-UHFFFAOYSA-N C(C(O)CO)C(C(=O)O)CCCCCCCCCC.C(CCCCCCCCCCC)(=O)OCC(O)CO Chemical compound C(C(O)CO)C(C(=O)O)CCCCCCCCCC.C(CCCCCCCCCCC)(=O)OCC(O)CO PSIDAWVKSCOUEN-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229940081620 ceteth-2 Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 238000002296 dynamic light scattering Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 125000005908 glyceryl ester group Chemical group 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940099570 oleth-2 Drugs 0.000 description 1
- 229940095127 oleth-20 Drugs 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940031709 peg-30-dipolyhydroxystearate Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000056 polyoxyethylene ether Chemical class 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/044—Suspensions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a thermally stable suspension cosmetic composition, and more particularly, to a suspension cosmetic composition comprising a nonionic surfactant, a solubilizer and a terpene alcohol and capable of forming thermally stable micelles that can maintain their shape at high temperatures, and a suspension cosmetic comprising the same and stable at high temperatures.
Description
Technical Field
The present invention relates to a thermally stable suspension cosmetic composition, and more particularly, to a suspension cosmetic composition comprising a nonionic surfactant, a solubilizer and a terpene alcohol and capable of forming thermally stable micelles that can maintain their shape at high temperatures, and a suspension cosmetic comprising the same and stable at high temperatures.
Background
With the improvement of living standards and the increase of average life span, the desire of people to seek youthful beauty is gradually increased, and various commodities for the demand are being developed. In particular, in the modern day, as people have increased their attention to skin management, the demand for skin care products for the purpose of achieving self-skin management is increasing. Skin-care lotions, and essences for skin moisturizing purposes are composed of water-soluble and oil-soluble components, and a small amount of an amphiphilic substance such as a nonionic surfactant is used for the purpose of uniformly emulsifying them.
In general, a surfactant is used to solubilize a poorly soluble substance insoluble in water (solvent) uniformly. When the concentration of the surfactant exceeds the critical micelle concentration (cmc), the poorly soluble substance enters the micelle and is dissolved, thereby achieving solubilization. By bringing the system into such a solubilized state, thermodynamic stability can be imparted to the composition. In particular, in the production of a transparent aqueous base cosmetic such as a cosmetic water or a cosmetic liquid, an EO or PO addition type nonionic surfactant is blended as a solubilizer in the cosmetic in an appropriate amount in order to solubilize an emulsion such as a perfume composed of an ester, an aldehyde, a ketone, an alcohol, an ether, a phenol, a lactone, or the like in an aqueous solvent.
On the other hand, recently, silicone oils having high stability, various properties, and excellent feel in use have been used in cosmetics in large quantities as solubilizers. International publication No. WO2004-091562 discloses a cosmetic composition for achieving suspension, wherein a carboxyl group-modified silicone oil having a carboxyl group modified with a dimethylpolysiloxane chain, which exhibits high chemical reactivity and high adsorption among the above silicone oils, is used as a solubilizer. Further, japanese patent No. 3484300 discloses a cosmetic composition in which a polyether-modified silicone oil modified with a polyoxyethylene group in a dimethylpolysiloxane chain, which exhibits high emulsion stability, is used as a solubilizer. However, the suspension type cosmetics manufactured by the above prior art have the following problems: in the production process of cosmetics, turbidity frequently varies depending on temperature conditions, and particularly at a temperature equal to or higher than normal temperature, micelles exhibiting suspension properties in cosmetics are decomposed and rearranged by a stability mechanism as their thermodynamic energy increases, and the size decreases, and this irreversible phenomenon causes a decrease in turbidity, and it is difficult to produce cosmetics of uniform quality.
Documents of the prior art
Patent document
Patent document 1: international laid-open publication No. WO2004-091562
Patent document 2: japanese patent publication No. 3484300
Disclosure of Invention
In order to solve the above-described problems of the prior art, the present invention provides a thermally stable suspension cosmetic composition comprising a nonionic lipophilic surfactant and a nonionic hydrophilic surfactant as a solubilizer, and further comprising a terpene (terphene) alcohol in the above-described composition, and a suspension cosmetic comprising the above-described cosmetic composition and capable of maintaining a stable state of turbidity at high temperatures, and a micelle capable of forming a stable state of shape and size under a high temperature environment for a long period of time.
The present invention relates to a heat-stable suspension cosmetic composition comprising a nonionic surfactant having an HLB (hydrophilic-lipophilic balance) of 3 to 7, a solubilizer having an HLB of 10 to 16, and a terpene alcohol.
The thermally stable suspension cosmetic composition of the present invention contains a nonionic lipophilic surfactant that can provide stable turbidity without variation due to different production process conditions, and further contains a nonionic hydrophilic surfactant as a solubilizer and a terpene-based alcohol, and thus can form a nonionic lipophilic surfactant-nonionic hydrophilic surfactant micelle in which the terpene-based alcohol crystal is present in the hydrophobic interior, and thus can provide an effect of enabling the production of a stable suspension cosmetic that can maintain turbidity even when stored in a high-temperature environment for a long time.
Detailed Description
The heat-stable suspension cosmetic composition of the present invention will be described in detail below. The embodiments described below are provided as examples to fully convey the concept of the present invention to those skilled in the art. In addition, unless defined otherwise, technical and scientific terms used have the meaning commonly understood by one of ordinary skill in the art to which this invention belongs. In the following description, a description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.
The present invention relates to a thermally stable suspension cosmetic composition capable of maintaining turbidity even when stored in a high-temperature environment for a long time, and more particularly to a thermally stable suspension cosmetic composition comprising: a nonionic lipophilic surfactant (hereinafter referred to as nonionic surfactant) having an HLB (hydrophile-lipophile balance) of 3 to 7, a hydrophilic solubilizer having an HLB of 10 to 16, and a terpene alcohol.
The nonionic surfactant contained in the cosmetic composition of the present invention may include one or more compounds selected from among polysorbates, sorbitan esters, polyoxyethylene fatty acid esters, polyoxyethylene ether esters, polyoxyethylene glycol esters, glyceryl esters, and sucrose esters, and may include one or more compounds selected from among ethylene glycol stearate, sorbitan sesquioleate, sorbitan 2-sorbitan isostearate, and sorbitan 2-isostearate, and polyoxyethylene sorbitan fatty acid esters having HLB of 3 to 7 One or more compounds selected from oleyl polyether-2 (oleth-2), glyceryl laurate (glyceryl laurate), cetyl polyether-2 (ceteth-2), polyethylene glycol-30 dipolyhydroxystearate (PEG-30dipolyhydroxystearate), sucrose cocoate (sucrose cocoate), polyethylene glycol-4 dilaurate (PEG-4dilaurate), and methyl glucose sesquistearate. In the present invention, the nonionic surfactant may preferably contain a sorbitan ester-based compound, and more specifically, may contain one or more compounds selected from sorbitan sesquioleate, sorbitan oleate, sorbitan monostearate, sorbitan isostearate, and the like, but is not particularly limited thereto.
The solubilizing agent contained in the cosmetic composition of the present invention may be a hydrophilic nonionic surfactant, and the solubilizing agent may include one or more compounds selected from among polysorbate (polysorbate), glycoside (glycoside), polyoxyethylene fatty acid ester (polyoxyethylene fatty acid ester), fatty acid amide (fatty acid amide), polyethylene glycol ester (polyethylene glycol ester), glyceride (glycerol ester) and glyceride (glycerol) compounds having an HLB (hydrophile-lipophile balance) of 10 to 16, and more particularly, may include PEG-7, PEG-20, PEG-60, and PEG-60, polyethylene glycol mono (glycerol ester), and PEG-25, hydrogenated castor oil (castor oil-25) esters, Polyethylene glycol-60 hydrogenated castor oil (PEG-60hydrogenated castor oil), stearamide (stearamide), polyethylene glycol-100 stearate (PEG-100stearate), polysorbate85 (polysorbate85), polysorbate 80(polysorbate 80), polysorbate 60(polysorbate 60), polyethylene glycol-7 olive oleate (PEG-7 oleate), cetearyl glucoside (cetearyl glucoside), polyethylene glycol-8 oleate (PEG-8oleate), oleyl ether-10 (oleth-10), oleyl ether-20 (oleth-20), ceteth-10 (ceteth-10), ceteth-20 (ceteth-20), polyethylene glycol-8 laurate (PEG-8laurate), cocamide (cocamide), isostearyl polyether-20 (isosteareth-20), Ceteareth-20 (ceteareth-20), steareth-20 (steareth-20), steareth-21 (steareth-21), and the like. The solubilizer of the present invention may preferably include a fatty acid triglyceride (triglyceride) compound obtained by adding 40 to 80 moles of ethylene oxide to polyethylene glycol-25 hydrogenated castor oil, polyethylene glycol-60 hydrogenated castor oil, and the like among the above compounds, but is not particularly limited thereto.
The nonionic surfactant and the solubilizer are contained in the cosmetic composition of the present invention, and form micelles (micella) having a large particle size of 100 to 1000 μm and containing a hydrophobic group therein, and the formed micelles can exhibit suspensibility.
In the present invention, the terpene-based alcohol is a crystalline compound located inside the hydrophobic group of the micelle formed by the combination of the nonionic surfactant and the solubilizer, and may include one or more selected from terpineol (terpineol), geraniol (geraniol), linalool (linalool), rhodinol (rhodinol), nerol (nerol), nerolidol (nerolidol), farnesol (farnesol), and menthol (menthenthol), but is not limited thereto.
In the present invention, the terpene alcohol is preferably located in the hydrophobic group of the formed micelle, and therefore, the terpene alcohol can inhibit the decomposition reaction of the micelle in an unstable state due to the molecular rearrangement to increase the activation energy required for the action of the stabilization mechanism, and therefore, even if the micelle is exposed to a high-temperature environment for a long time and becomes an unstable state having high energy, the irreversible decomposition (rearrangement) reaction of the micelle due to the stabilization mechanism hardly occurs, and therefore, the effect of producing a cosmetic having uniform and stable turbidity without reducing the turbidity of the cosmetic during the production process and during storage at high temperature can be obtained.
In the present invention, the nonionic surfactant and the solubilizer for forming micelles may be included in a weight ratio of 1:0.5 to 1, and preferably 1:0.6 to 0.75. The content ratio of the nonionic surfactant to the solubilizer is not particularly limited, but when the content ratio satisfies the above range, micelles having a large particle size and a stable state, which can exhibit turbidity, can be efficiently produced, which is preferable.
In the present invention, the total content of the nonionic surfactant and the solubilizer is 0.1 to 10% by weight, preferably 0.5 to 5% by weight, and more preferably 1 to 3% by weight, based on the total composition. The total content range of the nonionic surfactant and the solubilizer is not particularly limited, but when the total content range is satisfied, an effect that turbidity of a proper level required for the suspension cosmetic can be achieved and the produced suspension cosmetic has a very excellent feeling in use can be obtained, which is preferable.
In the present invention, the terpene-based alcohol may be contained in an amount of 0.05 to 5% by weight, preferably 0.1 to 3% by weight, based on the total composition. The content range of the terpene-based alcohol is not particularly limited, but when the content range is satisfied, the efficiency of forming micelles in which the terpene-based alcohol is present in the internal hydrophobic group is maximized in the process of forming micelles by binding the nonionic surfactant of the present invention and the solubilizer.
The present invention may include a suspension cosmetic composition containing the above-described heat-stable suspension cosmetic composition, and the above-described suspension cosmetic composition may contain, in addition to a suspension lotion or a cosmetic liquid for the purpose of skin care, an ultraviolet blocking agent, a suntan oil, a cleansing agent, a mask, a foundation cream, and the like, and is not particularly limited thereto. The method for preparing the suspension cosmetic is not particularly limited, and a general method known in the art may be used without limitation.
The above-mentioned suspension cosmetic of the present invention may contain, in addition to the above-mentioned heat-stable suspension cosmetic composition, ingredients generally used in cosmetic compositions, such as a moisturizing agent, an antioxidant, a chelating agent, a stabilizer, a pigment, a vitamin, an ultraviolet absorber, a bactericide, an anti-inflammatory agent, a preservative, a plant extract, and a pharmaceutical agent, within a range that does not affect the effects of the cosmetic composition of the present invention.
In the following, preferred embodiments are provided to aid in understanding the present invention. However, the following examples are only provided to facilitate understanding of the present invention, and the content of the present invention is not limited to the examples, and various modifications and changes can be made.
First, the experimental method carried out in the present invention is provided.
Here, the term "experimental substance" used in experiments 1) to 2) described below is used as a word indicating "the suspended skin lotion produced in examples 1 to 7" or "the suspended skin lotion produced in comparative examples 1 to 4".
Experiment 1) determination of micelle size under different temperature conditions
The test substances of examples 1 to 7 and comparative examples 1 to 4 were stored at-10 ℃, 25 ℃ and 60 ℃ for 2 weeks, and then the average micelle size present in each test substance was measured by a particle sizer (Zetasizer Nano ZS) (dynamic light Scattering, hereinafter referred to as DLS) from Malvern instrument.
Experiment 2) determination/Observation of turbidity of test substances under different temperature conditions
The test substances of examples 1 to 7 and comparative examples 1 to 4 were stored at 60 ℃ for 2 weeks, and then the turbidity exhibited by each test substance was measured by a Hayner instrument (HANA Instrument) HI98703 (Turbidimeter, Spec (0.1-1000 NTU)).
[ example 1]
0.80g of sorbitan sesquioleate (Sorbitanesequiolate) as a nonionic surfactant, 0.60g of PEG-60hydrogenated castor oil as a solubilizer, 0.3g of l-menthol as a terpene alcohol, 8.0g of 1, 3-butylene glycol, 7.0g of ethanol, 0.30g of phenoxyethanol, 0.05g of ethylhexylglycerin as a humectant, 0.02g of EDTA-2Na as a chelating agent, and 0.10g of a fragrance were added to a flask, and then purified water was added to the flask so that the total amount of the cosmetic composition became 100g, followed by mixing to prepare a suspension lotion.
[ example 2]
In the same manner as in example 1 except that 1.60g of sorbitan sesquioleate and 0.90g of PEG-60hydrogenated castor oil were added, a skin lotion for suspension was prepared.
[ example 3]
In the same manner as in example 1 except that 0.88g of sorbitan sesquioleate and 0.52g of PEG-60hydrogenated castor oil were added, a skin lotion for suspension was prepared.
[ example 4]
In the same manner as in example 1 except that 0.78g of sorbitan sesquioleate and 0.62g of PEG-60hydrogenated castor oil were added, a skin lotion for suspension was prepared.
[ example 5]
In the same manner as in example 1 except that 0.74g of sorbitan sesquioleate and 0.66g of PEG-60hydrogenated castor oil were added, a skin lotion for suspension was prepared.
[ example 6]
In the above example 1, except that 0.05g of l-menthol was added, the same procedure was followed to prepare a suspension lotion.
[ example 7]
In the above example 1, except that 3g of l-menthol was added, the same procedure was followed to prepare a suspension lotion.
Comparative example 1
In the same manner as in example 1 except that 1g of sorbitan sesquioleate and 0.4g of PEG-60hydrogenated castor oil were added, a skin lotion suspension was prepared.
Comparative example 2
In the same manner as in example 1 except that 0.67g of sorbitan sesquioleate and 0.73g of PEG-60hydrogenated castor oil were added, a skin lotion for suspension was prepared.
Comparative example 3
In the above example 1, a suspension lotion was prepared in the same manner as above except that 0.01g of l-menthol was added.
Comparative example 4
In the same manner as in example 1 above except that 0.03g of l-menthol was added, a suspension lotion was prepared.
The sizes of micelles present in the cosmetics under different temperature conditions in examples 1 to 7 and comparative examples 1 to 4 were measured by the methods of experiment 1 and experiment 2, and the results are shown in table 1 below, and the turbidity exhibited by the cosmetics in examples 1 to 7 and comparative examples 1 to 4 was measured, and the results are shown in table 2 below.
[ TABLE 1]
[ TABLE 2]
| Turbidity [ NTU] | |
| Example 1 | 604 |
| Example 2 | 1000 |
| Example 3 | 637 |
| Example 4 | 583 |
| Example 5 | 562 |
| Example 6 | 600 |
| Example 7 | 658 |
| Comparative example 1 | Spec-over |
| Comparative example 2 | 381 |
| Comparative example 3 | 435 |
| Comparative example 4 | 472 |
As is clear from the results in table 1, the suspension cosmetics produced in examples 1 to 7 according to the present invention did not change the micelle size greatly even when stored at room temperature for a long time or at a low or high temperature for a long time, and the cosmetics produced at room temperature could maintain the turbidity even when stored at various temperatures. In particular, the micelle size present in the cosmetics of comparative examples 1 to 4 was reduced by 70 to 81% at a temperature of 60 ℃, and as compared with this result, it was confirmed that the micelles in the cosmetics of examples 1 to 7 according to the present invention showed a very stable state even when stored at a high temperature for a long time, and thus it was confirmed that the turbidity of the cosmetics was also maintained stably.
Further, from the results of example 1 and comparative examples 1 to 2 in table 2, it is understood that when the nonionic surfactant and the solubilizer contained in the cosmetic composition of the present invention satisfy the weight ratio of 1:0.5 to 1, the produced cosmetic exhibits a turbidity of 550NTU or more and a turbidity suitable for use as a suspension cosmetic even after being stored at a temperature of 60 ℃ for two weeks, but when the content ratio of the nonionic surfactant and the solubilizer does not satisfy the above range, it is confirmed that the produced cosmetic exhibits a low turbidity of 500NTU or less, and particularly when being stored at a high temperature, the turbidity is further reduced and gradually becomes transparent.
Claims (5)
1. A heat-stable suspension cosmetic composition comprising a nonionic surfactant having an HLB of 3 to 7, a solubilizer having an HLB of 10 to 16, and a terpene alcohol,
the nonionic surfactant and the solubilizer are contained in a weight ratio of 1: 0.5-1,
the total content of the nonionic surfactant and the solubilizer is 0.1-10 wt% relative to the total composition,
the terpene alcohol is contained in an amount of 0.05 to 5 wt% based on the whole composition.
2. The thermally stable suspending cosmetic composition according to claim 1, wherein the nonionic surfactant comprises a sorbitan ester based compound.
3. The thermally stable suspension cosmetic composition according to claim 1, wherein the solubilizer comprises an aliphatic triglyceride-based compound to which 40 to 80 moles of ethylene oxide is added.
4. The heat-stable suspension cosmetic composition according to claim 1, wherein the terpene-based alcohol comprises one or more selected from the group consisting of terpineol, geraniol, linalool, rhodinol, nerol, nerolidol, farnesol and menthol.
5. A suspension cosmetic comprising the heat-stable suspension cosmetic composition according to any one of claims 1 to 4.
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