CN106990068B - A method and system for online monitoring of blood urea nitrogen and creatinine content in hemodialysis fluid - Google Patents

Abstract

The invention relates to an online monitoring method and system for urea nitrogen creatinine content in hemodialysis fluid. A near-infrared spectrometer is used to establish a dialysate sample inspection model and to monitor online the change of urea nitrogen creatinine content in hemodialysis fluid. According to the hemodialysis fluid The content of blood urea nitrogen and creatinine in blood can be monitored regularly to prevent and avoid hemodialysis accidents, so as to provide a scientific basis for the treatment of uremia patients and achieve the purpose of improving the treatment level of patients with nephropathy.

Description

A method and system for online monitoring of blood urea nitrogen and creatinine content in hemodialysis fluid

technical field

The invention relates to an online monitoring method and system for urea nitrogen creatinine content in hemodialysis fluid, in particular to an online monitoring method and system for blood urea nitrogen creatinine content in hemodialysis fluid using near-infrared spectrum detection.

Background technique

At present, blood purification is widely required in clinical treatment. Taking dialysis treatment of kidney disease as an example, there are about 2 million patients with end-stage renal disease in my country, 400,000 of whom are receiving hemodialysis treatment, which is increasing at a rate of more than 10% every year. Patients have a great demand for dialysis treatment.

Hemodialysis uses the principle of semi-permeable membrane to introduce the patient's blood and dialysate into the inner and outer sides of the dialyzer at the same time. With the help of the solute gradient, osmotic gradient and diffusivity on both sides of the membrane, through diffusion, convection, and removal of toxins, etc., Through this method, excess water and metabolic wastes retained in the body are removed, while the required substances are left, and electrolyte and acid-base balance disorders are corrected.

Urea is the main end product of protein metabolism in the human body. Deamination of amino acids produces NH ₃ and C0 ₂ , which are synthesized in the liver to produce urea. Each gram of protein metabolism produces about 0.3 grams of urea nitrogen. Usually, the kidney is the main organ for excreting urea, and urea can be reabsorbed in various tubules after being filtered from the glomerulus. Normal adult fasting urea nitrogen is 3.2 ~ 7.1mmol/L (9 ~ 20mg/d1). Various renal parenchymal diseases, such as glomerulonephritis, interstitial nephritis, acute and chronic renal failure, etc., can increase blood urea nitrogen. If extrarenal factors can be excluded, blood urea nitrogen 21.4mmol/L (60mg/d1) is one of the diagnostic indicators for uremia.

Creatinine (CR) is a product of human muscle metabolism. It is mainly formed slowly by creatine through an irreversible non-enzymatic dehydration reaction, and then released into the blood, excreted with urine, not easily affected by diet, and can be filtered through the glomerulus. It is rarely reabsorbed in tubules. Creatinine includes blood creatinine and urine creatinine. Serum creatinine is more meaningful to measure renal function. Serum creatinine concentration is an effective indicator for evaluating glomerular filtration rate, which can effectively reflect the substantial damage of renal function It is of great significance to detect the disease clinically and help to judge the condition.

Dialyzers are used for hemodialysis in uremic patients. The dialyzer may be clogged or broken. The main reasons for the blockage of the dialyzer are: a. The time for the blood to leave the pump is too long, which is the main reason for the blockage of the dialyzer; b. The amount of heparin used is insufficient. The amount of heparin injected for the first dialysis is very important, generally 0.2-0.5 mg /kg, if the first heparinization is insufficient, no amount of heparin added during dialysis will have any obvious effect; c. Dialysis patients themselves have increased blood viscosity due to diseases and end-stage renal disease.

If the dialyzer is blocked, it should be replaced in time. Otherwise, the extracorporeal circulation will stop, and the arterial and venous blood channels will also be blocked, resulting in a large amount of blood loss for the dialyzer, which is extremely harmful. The process of observing the blockage of the dialyzer is generally 5 to 10 minutes. In order to detect the blockage of the dialyzer in time, it is necessary to monitor the dialysis process on-line to find out the change rule of the dialysate concentration. For example, when the dialysis membrane is gradually blocked, the urea nitrogen content in the dialysate will gradually decrease. When the normal urea nitrogen content exceeds a certain limit, the alarm device can be used to remind in time to effectively avoid the occurrence of harm.

Furthermore, by monitoring the change of blood urea nitrogen creatinine content in the hemodialysis solution online, the breakage of the dialyzer can be detected in time. If the hollow fiber membrane of the dialyzer is damaged, the urea nitrogen content in the dialysate will increase significantly. Through monitoring, the dialyzer damage can be found in time, and the accident can be avoided by timely treatment.

The existing technology uses conductivity detection, dialysate concentration monitoring, etc. for prevention, but there are also certain shortcomings, such as insufficient timeliness of sampling detection and pollution, concentration monitoring requires high-precision sensors, and sensor probes may cause corrosion. The occurrence of inaccurate measurement values, etc.

Near-infrared spectroscopy is a new technology that has only been developed in recent years. It is an instrumental analysis method that uses near-infrared spectrometers to quickly scan the reflection, diffuse reflection or transmission spectra of substances in the 670-2526nm spectral region. Due to the advantages of fast analysis speed, high efficiency, no chemical pollution of samples, no need for sample pretreatment, and online non-destructive testing, near-infrared spectroscopy has been widely used in the fields of food and agricultural product testing. However, literature search did not find its application in the field of hemodialysis online monitoring.

Therefore, how to combine the advantages of near-infrared spectrum detection technology to monitor the change of blood urea nitrogen creatinine in hemodialysis fluid online, find the change rule of blood urea nitrogen creatinine content in hemodialysis fluid, and find out the blood urea nitrogen creatinine content in hemodialysis fluid. The correlation between the content change and the patient's heart rate, blood pressure, and dialysis blood flow, and the search for the change rule of the urea nitrogen creatinine content in the dialysate under special circumstances such as blockage or damage have become one of the research topics in this field.

Contents of the invention

The present invention aims to solve the problems existing in the prior art, and provides an online monitoring method and system for the content of urea nitrogen and creatinine in the hemodialysis fluid, using a near-infrared spectrometer to establish a dialysate sample inspection model and online monitoring of the blood urea nitrogen in the hemodialysis fluid The change of creatinine content can achieve the purpose of preventing the occurrence of hemodialysis accidents and improving the treatment level of nephropathy.

The invention provides a method for on-line monitoring of blood urea nitrogen creatinine content in hemodialysis fluid, comprising the following steps:

1) Prepare hemodialysis fluid samples with different urea nitrogen content and creatinine content;

2) Using a near-infrared spectrometer to collect spectra of hemodialysate samples with urea nitrogen content and creatinine content;

3) Establish a quantitative identification model for blood urea nitrogen and creatinine in hemodialysis fluid based on near-infrared spectroscopy;

4) Use the online monitoring probe to collect near-infrared spectrum of the dialysate at the outlet of the hemodialyzer, and compare the near-infrared spectrum of the urea nitrogen content and creatinine content in the dialysate at the outlet of the dialyzer with the urea nitrogen in the dialysate established in step 3). BUN content and creatinine content quantitative identification model were compared to determine the urea nitrogen creatinine content in the dialysate at the outlet of the dialyzer to be tested.

In addition, the present invention also provides an on-line monitoring system for blood urea nitrogen creatinine content in hemodialysate, including: blood side circulation, dialysate side circulation and dialyzer 4; blood side circulation includes human arterial blood output side 1, blood pump 2. The arterial blood circulation conduit 3, the venous blood circulation conduit 6 and the human body venous blood input side 8; the arterial blood circulation conduit 3 connects the human body arterial blood output side 1 and the blood inlet of the dialyzer 4, and the blood pump 2 is arranged on the arterial blood circulation conduit 3. The venous blood circulation conduit 6 connects the blood outlet of the dialyzer 4 and the human venous blood input side 8; the dialysate side circulation includes a dialysate bucket 9, a dialysate pump 10, a dialysate inlet pipeline 11, and a dialysate monitoring probe 14 , dialysate outlet pipeline 13, dialysate recovery bucket 15, near-infrared spectrum detection data line 16 and near-infrared spectrum monitor 17; dialysate inlet pipeline 11 connects the dialysate inlet of dialysate barrel 9 and dialyzer 4, dialysate pump 10 is arranged on the dialysate inlet pipeline 11; the dialysate outlet pipeline 13 connects the dialysate inlet of the dialyzer 4 and the dialysate recovery bucket 15; the dialysate monitoring probe 14 is arranged on the dialysate outlet pipeline 13, and the near-infrared spectrum detection data line 16 connects the dialysate monitoring probe 14 and the near-infrared spectrum monitor 17; the dialysate monitoring probe 14 collects the near-infrared spectrum of the urea nitrogen creatinine content in the dialysate coming out from the dialyzer 4 .

Further, the present invention also provides an on-line monitoring system for urea nitrogen creatinine content in hemodialysis fluid, which also has the following features: the near-infrared spectrum monitor 17 obtains the near-infrared spectrum of the urea nitrogen creatinine content in the dialysate from the dialysate monitoring probe 14 , based on near-infrared spectroscopy quantitative identification model comparison of urea nitrogen creatinine content in hemodialysis fluid to obtain the content of urea nitrogen creatinine in hemodialysis fluid and record it in real time.

Further, the present invention also provides an online monitoring system for blood urea nitrogen creatinine content in hemodialysis fluid, which also has the following characteristics: the quantitative identification model of blood urea nitrogen creatinine content in hemodialysis fluid based on near-infrared spectroscopy refers to the preparation of different blood urea nitrogen content , creatinine content of the hemodialysis fluid sample, using the near-infrared spectrometer to collect the spectrum of the dialysate sample, so as to establish a quantitative identification model for the content of urea nitrogen and creatinine in the hemodialysis fluid based on near-infrared spectroscopy.

Further, the present invention also provides an on-line monitoring system for blood urea nitrogen creatinine content in hemodialysis fluid, which also has the following features: the on-line monitoring system for blood urea nitrogen creatinine content in hemodialysis fluid is provided with a bubble capture monitor 7 arranged in the venous blood circulation On conduit 6.

Further, the present invention also provides an on-line monitoring system for blood urea nitrogen creatinine content in hemodialysis fluid, which also has the following features: the dialysate monitoring probe 14 includes a probe housing 21, a dialysate channel 24, a near-infrared receiving chamber 29 and a near-infrared Emitting chamber 32; near-infrared receiving chamber 29 and near-infrared emitting chamber 32 are respectively arranged on both sides of the probe housing 21, and the dialysate channel 24 runs through the probe housing 21 in the middle, and the near-infrared receiving chamber 29 and the near-infrared emitting chamber 32 pass through the probe housing 21 respectively. The near-infrared receiving hole 25 and the near-infrared emitting hole 30 are connected to the dialysate channel 24, and the near-infrared receiving hole 25 and the near-infrared emitting hole 30 are coaxial; the near-infrared emitting chamber 32 is provided with a near-infrared emitting tube at the position of the near-infrared emitting hole 30 31; the near-infrared receiving room 29 is provided with a near-infrared receiving tube 27 at the position of the near-infrared receiving hole 25; the near-infrared receiving room 29 is provided with a circuit board 28 and communicates with the near-infrared receiving tube 27; the dialysate channel 24 is dialyzed with the dialyzer 4 The liquid outlet or dialysate outlet pipeline 13 is connected and transported to the used dialysate recovery bucket 15; the outside of the probe housing 21 is provided with a connector 23, and the connector 23 communicates with the near-infrared receiving chamber 29 and the near-infrared emitting chamber through the wire hole 22 32 and the outside; the dialysate channel 24 is provided with quartz glass 33 to cover the near-infrared receiving hole 25 and the near-infrared emitting hole 30; the dialysate monitoring probe 14 also includes two sealing covers 26 connected to the probe housing 21 to form a near-infrared receiving chamber 29 and near-infrared emitting chamber 32; near-infrared light monitors the dialysate in the dialysate channel 24, and the spectral signal collected is drawn from the conduit through the inner wire of the dialysate monitoring probe 14 through the connector 23, and is detected by the near-infrared spectrum. The infrared spectrum monitoring instrument obtains the urea nitrogen creatinine content in the hemodialysis fluid and records it in real time.

Further, the present invention also provides an on-line monitoring system for blood urea nitrogen and creatinine content in hemodialysis fluid, which also has the following features: the sealing cover 26 is connected to the probe housing 21 through sealing threads.

Further, the present invention also provides an on-line monitoring system for blood urea nitrogen and creatinine content in hemodialysate, which also has the following features: the connecting head 23, the probe housing 21 and the sealing cover 26 are made of stainless steel.

Further, the present invention also provides an on-line monitoring system for urea nitrogen and creatinine content in hemodialysis fluid, which also has the following features: near-infrared light vertically penetrates the dialysate in the dialysate channel 24 .

Further, the present invention also provides an on-line monitoring system for blood urea nitrogen creatinine content in hemodialysis fluid, which also has the following features: the on-line monitoring system for blood urea nitrogen creatinine content in hemodialysis fluid is equipped with a heparin pump 20, which is installed in the arterial blood circulation catheter 3 above; the prepared injection is injected into the blood through the heparin pump 20 .

The technical characteristics and experimental steps not described in the present invention are matched with mature prior art.

Beneficial Effects of the Invention

1. By monitoring the content of urea nitrogen and creatinine in the dialysate in real time online, it can quickly determine whether the dialyzer is blocked or damaged, so as to deal with it in time and prevent the occurrence of medical accidents;

2. The detection time of online monitoring is short, and the obtained data of urea nitrogen creatinine content in the dialysate is large, which is helpful to find out the change rule of the blood urea nitrogen creatinine content in the dialysate during hemodialysis, and helps to find the urea in the dialysate during hemodialysis. The correlation between the change of nitrogen creatinine content and the patient's heart rate, blood pressure, and dialysis blood flow, so as to provide a scientific basis for the treatment of uremia patients;

3. Realize rapid non-destructive testing. Compared with other monitoring methods, human errors and system errors are effectively reduced, and the accuracy of the model is high, which improves work efficiency;

4. It provides a reliable technical guarantee for the prevention, treatment and first aid of kidney disease, and has great economic and social significance.

Description of drawings

FIG. 1 is a schematic diagram of an online monitoring system for blood urea nitrogen and creatinine content in hemodialysis fluid according to the present invention.

Fig. 2 is a schematic structural diagram of the dialysate monitoring probe in the present invention.

Reference signs:

1-human arterial blood output side; 2-blood pump; 3-arterial blood circulation catheter; 4-dialyzer; 5-hollow fiber membrane; 6-venous blood circulation catheter; 7-bubble capture monitor; 8-human venous blood Input side; 9-clean dialysate bucket; 10-dialysate pump; 11-dialysate inlet line; 12-dialysate side of dialyzer; 13-dialysate outlet line; 14-dialysate monitoring probe; 15-used Dialysate recovery barrel; 16-near-infrared spectrum detection data line; 17-near-infrared spectrum monitor; 20-heparin pump; 21-probe housing; 22-wire hole; 23-connector; -near-infrared receiving hole; 26-sealed cover; 27-near-infrared receiving tube; 28-circuit board; 29-near-infrared receiving room; 30-near-infrared emitting hole; 31-near-infrared emitting tube; ; 33 - Quartz glass.

Detailed ways

The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

A method for on-line monitoring of blood urea nitrogen and creatinine content in hemodialysis fluid, comprising the steps of:

1) Prepare hemodialysis fluid samples with different urea nitrogen content and creatinine content, and the number of samples meets the requirements for establishing a sample inspection model;

2) Using a near-infrared spectrometer to collect spectra of hemodialysate samples with urea nitrogen content and creatinine content;

3) Establish a quantitative identification model for urea nitrogen content and creatinine content in hemodialysis fluid based on near-infrared spectroscopy;

4) Use the online monitoring probe to collect near-infrared spectrum of the dialysate at the outlet of the hemodialyzer, and compare the near-infrared spectrum of the urea nitrogen content and creatinine content in the dialysate at the outlet of the dialyzer with the urea nitrogen in the dialysate established in step 3). BUN content and creatinine content quantitative identification model were compared to quickly determine the urea nitrogen creatinine content in the dialysate at the outlet of the dialyzer to be tested.

FIG. 1 is a schematic diagram of an online monitoring system for blood urea nitrogen and creatinine content in hemodialysis fluid according to the present invention.

As shown in FIG. 1 , an online monitoring system for blood urea nitrogen and creatinine content in hemodialysis fluid includes: blood side circulation, dialysate side circulation and dialyzer 4 . The dialyzer 4 has hollow fiber membranes 5 and a dialysate side 12 .

The blood side circulation includes human arterial blood output side 1 , blood pump 2 , arterial blood circulation conduit 3 , venous blood circulation conduit 6 and human venous blood input side 8 . The arterial blood circulation conduit 3 connects the human arterial blood output side 1 and the blood inlet of the dialyzer 4, and the blood pump 2 is arranged on the arterial blood circulation conduit 3; the venous blood circulation conduit 6 connects the blood outlet of the dialyzer 4 and the human venous blood input side 8.

The dialysate side circulation includes dialysate tank 9, dialysate pump 10, dialysate inlet pipeline 11, dialysate monitoring probe 14, dialysate outlet pipeline 13 dialysate recovery bucket 15, near-infrared spectrum detection data line 16 and near-infrared spectrum Monitor17. The dialysate inlet line 11 is connected to the dialysate tank 9 and the dialysate inlet of the dialyzer 4, and the dialysate pump 10 is arranged on the dialysate inlet line 11; the dialysate outlet line 13 is connected to the dialysate outlet of the dialyzer 4 and the dialysate recovery bucket 15; the dialysate monitoring probe 14 is arranged on the dialysate outlet pipeline 13, and the near-infrared spectrum detection data line 16 connects the dialysate monitoring probe 14 and the near-infrared spectrum monitor 17; The near-infrared spectrum of urea nitrogen creatinine content in the liquid; The near-infrared spectrum monitor 17 obtains the near-infrared spectrum of the urea nitrogen creatinine content in the dialysate from the dialysate monitoring probe 14, and the blood urea nitrogen creatinine content in the hemodialysis fluid based on the near-infrared spectrum The content of urea nitrogen and creatinine in the hemodialysate was obtained by quantitative identification model comparison and recorded in real time.

An on-line monitoring system for blood urea nitrogen and creatinine content in hemodialysis fluid, further comprising a bubble capture monitor 7 and a heparin pump 20 . The bubble capture monitor 7 is arranged on the venous blood circulation catheter 6 . The heparin pump 20 is installed on the arterial blood circulation catheter 3 .

A working process of an online monitoring system for blood urea nitrogen and creatinine content in hemodialysis fluid: the blood output from the human arterial blood output side 1 of the blood side circulation enters the dialyzer 4 through the blood pump 2 and the arterial blood circulation catheter 3 , and the blood passes through the dialyzer 4 The hollow fiber membrane 5 in the middle performs solute exchange with the dialysate, and then returns to the human body through the venous blood circulation catheter 6 and the human venous blood input side 8 . The dialysate in the clean dialysate bucket 9 circulating on the dialysate side enters the dialysate side 12 of the dialyzer through the dialysate pump 10 and the dialysate inlet pipeline 11, exchanges solutes with the blood in the hollow fiber membrane 5, and is then monitored by the dialysate The dialysate channel in the probe 14 and the dialysate outlet pipeline 13 enter the used dialysate recovery bucket 15; the dialysate monitoring probe 14 collects the near-infrared spectrum of the dialysate coming out from the dialyzer 4, and detects the data line 16 through the near-infrared spectrum The near-infrared spectrum monitor 17 is compared with the quantitative identification model of urea nitrogen content and creatinine content in the hemodialysis fluid based on near-infrared spectroscopy to obtain the content of urea nitrogen and creatinine in the hemodialysis fluid and record it in real time.

The quantitative identification model of urea nitrogen content and creatinine content in hemodialysis fluid based on near-infrared spectroscopy refers to preparing hemodialysis fluid samples with different urea nitrogen content and creatinine content, and using a near-infrared spectrometer to collect the spectrum of the dialysate sample. A quantitative identification model for urea nitrogen and creatinine in hemodialysis fluid based on near-infrared spectroscopy was established.

The blood coming out from the dialyzer 4 returns to the human body through the venous blood circulation conduit 6, the bubble capture monitor 7, and the human body venous blood input side 8.

The blood output from the arterial blood output side 1 of the human body enters the dialyzer 4 through the blood pump 2 , the heparin pump 20 , and the arterial blood circulation catheter 3 ; the prepared injection is injected into the blood through the heparin pump 20 .

Fig. 2 is a schematic structural diagram of the dialysate monitoring probe in the present invention.

As shown in Figure 2, the dialysate monitoring probe 14 includes a probe housing 21, a dialysate channel 24, a near-infrared receiving chamber 29, and a near-infrared emitting chamber 32; The two sides of body 21, in the middle, the dialysate channel 24 runs through the probe housing 21, the near-infrared receiving chamber 29 and the near-infrared emitting chamber 32 communicate with the dialysate channel 24 through the near-infrared receiving hole 25 and the near-infrared emitting hole 30 respectively, and the near-infrared receiving chamber Hole 25 and near-infrared emission hole 30 are coaxial; Near-infrared emission chamber 32 is provided with near-infrared emission tube 31 at the position of near-infrared emission hole 30; Tube 27; near-infrared receiving chamber 29 is provided with circuit board 28 and is communicated with near-infrared receiving tube 27; dialysate channel 24 is connected with dialyzer 4 dialysate outlet or dialysate outlet pipeline 13 and is transported to used dialysate recovery bucket 15 .

The outside of the probe housing 21 is provided with a connector 23, and the connector 23 communicates with the near-infrared receiving chamber 29, the near-infrared emitting chamber 32 and the outside through the wire hole 22; the dialysate channel 24 is provided with quartz glass 33 to cover the near-infrared receiving hole 25 and the near-infrared Infrared emission hole 30 ; the dialysate monitoring probe 14 also includes two sealing covers 26 connected to the probe housing 21 to form a near-infrared receiving chamber 29 and a near-infrared emitting chamber 32 .

The near-infrared light monitors the dialysate in the dialysate channel 24, and the collected spectral signal is drawn out from the conduit through the inner wire of the dialysate monitoring probe 14 through the connector 23, and the hemodialysis is obtained through the near-infrared spectrum detection data line and the near-infrared spectrum monitor. The blood urea nitrogen creatinine content in the dialysate was recorded in real time.

The sealing cover 26 is connected with the probe housing 21 through sealing threads.

The connecting head 23, the probe housing 21 and the sealing cover 26 are made of stainless steel.

The near-infrared light is vertically transmitted through the dialysate in the dialysate channel 24 .

The technical characteristics and experimental steps not described in the present invention are matched with mature prior art.

Although the present invention has been disclosed as above with preferred embodiments, they are not intended to limit the present invention, and any person skilled in the art can make changes, modifications, changes without departing from the spirit and scope of the present invention. Addition or replacement still belongs to the protection scope of the technical solution of the present invention.

Claims (8)

1. a blood urea nitrogen creatinine content online monitoring method in hemodialysis fluid, is characterized in that: comprise the steps: 1) Prepare hemodialysis fluid samples with different urea nitrogen content and creatinine content; 2) Using a near-infrared spectrometer to collect spectra of hemodialysate samples with urea nitrogen content and creatinine content respectively; 3) Establish a quantitative identification model for urea nitrogen content and creatinine content in hemodialysis fluid based on near-infrared spectroscopy; 4) Use the online monitoring probe to collect near-infrared spectrum of the dialysate at the outlet of the hemodialyzer, and compare the near-infrared spectrum of the urea nitrogen content and creatinine content in the dialysate at the outlet of the dialyzer with the urea nitrogen in the dialysate established in step 3). BUN content and creatinine content quantitative identification model were compared to determine the urea nitrogen creatinine content in the dialysate at the outlet of the dialyzer to be tested. 2. the on-line monitoring method of urea nitrogen creatinine content in the hemodialysate according to claim 1, is characterized in that: The quantitative identification model of urea nitrogen content and creatinine content in hemodialysis fluid based on near-infrared spectroscopy refers to preparing hemodialysis fluid samples with different urea nitrogen content and creatinine content, and using a near-infrared spectrometer to perform spectral analysis on the dialysate samples. In order to establish a quantitative identification model for urea nitrogen content and creatinine content in hemodialysis fluid based on near-infrared spectroscopy. 3. A blood urea nitrogen creatinine content on-line monitoring system in hemodialysis fluid, is characterized in that: comprise, blood side circulation, dialysate side circulation and dialyzer (4); Described blood side circulation comprises, human body arterial blood output side (1), blood pump (2), arterial blood circulation conduit (3), venous blood circulation conduit (6) and human body venous blood input side; The conduit (3) connects the blood inlet of the human arterial blood output side (1) and the dialyzer (4), and the blood pump (2) is arranged on the arterial blood circulation conduit (3); The blood circulation conduit (6) connects the blood outlet of the dialyzer (4) and the human body venous blood input side (8); The dialysate side circulation includes dialysate barrel (9), dialysate pump (10), dialysate inlet pipeline (11), dialysate monitoring probe (14), dialysate outlet pipeline (13), dialysate recovery Barrel (15) near-infrared spectrum detection data line (16) and near-infrared spectrum monitor (17); Described dialysate inlet line (11) connects described dialysate barrel (9) and described dialyzer (4) dialysate inlet, the dialysate pump (10) is arranged on the dialysate inlet line (11); the dialysate outlet line (13) connects the dialysate outlet of the dialyzer (4) and the dialysate Liquid recovery barrel (15); the dialysate monitoring probe (14) is arranged on the dialysate outlet pipeline (13), and the near-infrared spectrum detection data line (16) is connected to the dialysate monitoring probe (14) and the near-infrared spectrum monitor (17); the near-infrared spectrum of the urea nitrogen creatinine content in the dialysate from the dialyzer (4) collected by the dialysate monitoring probe (14); The near-infrared spectrum monitor (17) obtains the near-infrared spectrum of the urea nitrogen creatinine content in the dialysate from the dialysate monitoring probe (14), and the quantitative identification model of the blood urea nitrogen creatinine content in the hemodialysis fluid based on the near-infrared spectrum Compare and obtain the blood urea nitrogen creatinine content in the hemodialysis solution and record it in real time; The online monitoring system for blood urea nitrogen and creatinine content in the hemodialysate is provided with a bubble capture monitor (7), which is arranged on the venous blood circulation catheter (6). 4. the urea nitrogen creatinine content online monitoring system in the hemodialysate according to claim 3, is characterized in that: The dialysate monitoring probe (14) includes a probe housing (21), a dialysate channel (24), a near-infrared receiving chamber (29) and a near-infrared emitting chamber (32); the near-infrared receiving chamber (29 ) and near-infrared emitting chamber (32) are respectively located on the probe housing (21) both sides, the middle is run through the probe housing (21) by dialysate channel (24), near-infrared receiving chamber (29) and near-infrared emitting chamber ( 32) Connect the dialysate channel (24) through the near-infrared receiving hole (25) and the near-infrared emitting hole (30) respectively, and the near-infrared receiving hole (25) and the near-infrared emitting hole (30) are coaxial; the near-infrared Emitting room (32) is provided with near-infrared emitting tube (31) at the position of near-infrared emitting hole (30); Described near-infrared receiving chamber (29) is provided with near-infrared receiving room (25) Tube (27); described near-infrared receiving chamber (29) is provided with circuit board (28) and is communicated with near-infrared receiving tube (27); Described dialysate channel (24) and dialyzer (4) dialysate outlet Or the dialysate outlet pipeline (13) is connected and delivered to the used dialysate recovery bucket (15); The outside of the probe housing (21) is provided with a connector (23), and the connector (23) communicates with the near-infrared receiving chamber (29), the near-infrared emitting chamber (32) and the outside through the wire hole (22); Described dialysate channel (24) is provided with quartz glass (33) and covers near-infrared receiving hole (25) and near-infrared emitting hole (30); Described dialysate monitoring probe (14) also includes two sealing covers ( 26) Connect the probe housing (21) to form a near-infrared receiving chamber (29) and a near-infrared emitting chamber (32) respectively; The near-infrared light monitors the dialysate in the dialysate channel (24), and the collected spectral signal is drawn out from the conduit through the inner wire of the dialysate monitoring probe (14) through the connector (23), and the data line (16) is detected by the near-infrared spectrum. , The near-infrared spectrum monitor (17) obtains the urea nitrogen creatinine content in the hemodialysis solution and records it in real time. 5. the urea nitrogen creatinine content online monitoring system in the hemodialysate according to claim 4, is characterized in that: The sealing cover (26) is connected with the probe housing (21) through sealing threads. 6. the urea nitrogen creatinine content online monitoring system in the hemodialysate according to claim 4, is characterized in that: The connecting head (23), the probe housing (21) and the sealing cover (26) are made of stainless steel. 7. the urea nitrogen creatinine content online monitoring system in the hemodialysate according to claim 4, is characterized in that: The near-infrared light is vertically transmitted through the dialysate in the dialysate channel (24). 8. the urea nitrogen creatinine content online monitoring system in the hemodialysate according to claim 3, is characterized in that: The on-line monitoring system for blood urea nitrogen and creatinine content in the hemodialysis solution is provided with a heparin pump (20), which is arranged on the arterial blood circulation catheter (3); the prepared injection is injected into the blood through the heparin pump (20).

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