CN106957397A - Anti- all leak gel rubber materials and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-circumferential hydrogel material and a preparation method thereof. The preparation method comprises the steps of: mixing and dissolving a hydrophilic monomer and a cross-linking agent for preparing the hydrogel material in proportion to a phosphate buffer solution, and then Add a catalyst composed of vitamin B2 and L-arginine, mix it evenly, pour it into a mold, and carry out cross-linking under ultraviolet light at room temperature to obtain a hydrogel material product, and then wash it with alcohol to remove unreacted monomers. body and catalyst, and then dried to obtain the anti-circumferential leakage hydrogel material. The preparation method of the present invention catalyzes the cross-linking reaction by adopting vitamin B2 and L-arginine catalyst system, adopts raw materials with good biocompatibility, adopts green synthesis route, has simple operation, low cost and universal applicability Wide range and high controllability. The anti-peripheral leakage hydrogel material prepared by the preparation method of the invention has uniform thickness, good flexibility, fast water absorption and good anti-peripheral leakage effect.

Description

Anti-circumferential leakage hydrogel material and preparation method thereof

technical field

The invention relates to the field of biomedical materials, in particular to an anti-circumferential hydrogel material and a preparation method thereof.

Background technique

Aortic stenosis (aortic valve stenosis) refers to a disease in which various reasons lead to aortic valve hypertrophy, calcification and/or valve leaflets, valve fusion, and then lead to left ventricular outflow tract obstruction. With the deepening of population aging, the incidence of aortic valve stenosis is gradually increasing, and it has become the second most common heart valve disease in my country after mitral valve prolapse. Over the past 50 years, surgical implantation of prosthetic valves has been the most successful treatment. However, this kind of surgery requires open chest, which is too risky for some elderly and weak patients. Currently, transcatheter aortic valve implantation (TAVI) is the most promising technology for this situation.

Transcatheter aortic valve implantation is a surgery in which a bioprosthetic valve is delivered through a catheter through the peripheral artery or the apical route without removing the original diseased valve, and is fixed by balloon expansion and valve anchoring device. The artificial heart valve is first compressed into a delivery device, which delivers the valve to the heart lesion through the blood vessel, and then releases the artificial heart valve to replace the diseased native valve. Perivalvular leak (PPL) is a unique serious complication after valve replacement and is one of the common reasons for reoperation. The main reasons for its occurrence are the pathological changes of the valve ring tissue, the size mismatch between the artificial valve and the valve ring, and the endocarditis of the artificial valve. After paravalvular leak occurs, it is often accompanied by the following hazards: (1) paravalvular leak leads to severe hemolysis, anemia and progressive aggravation of hemoglobinuria; (2) large paravalvular leak causes abnormal changes in hemodynamics, making Decreased heart function or even heart failure, and the symptoms and signs did not improve significantly after conservative medical treatment; (3) The pervalvular leak is small, but it is complicated with infective endocarditis; (4) The paravalvular leak is complicated with bioprosthesis decay.

Currently commercially developed heart valves include balloon-expandable valves or self-expanding valves. Artificial heart valve replacement devices generally include a mesh-like stent made of memory metal materials, and a one-way openable stent sewn into the stent. The valve structure matches the lesion position as much as possible through the expansion force of the stent. Although paravalvular leakage can be reduced to a certain extent, due to the irregular shape of the inner wall of the blood vessel after autogenous calcification, different degrees of paravalvular leakage and peripheral regurgitation will still occur.

So far, various methods have been adopted to carry out sealing treatment to improve the effect of preventing leakage. US7780725B2, US0122587A1 etc. add skirts at the end of the valve to achieve a certain anti-peripheral leakage effect, and US7577477 uses injection of fibrin glue to seal, but these two cases are only applicable to the situation of slight peripheral leakage. CN105232187A, CN103889472B reach the effect of anti-circumferential leakage by adopting the hydrogel component of sealing, the used ammonium persulfate (APS) and tetramethylethylenediamine (TEMED) catalyst system have the effect of gelling fast, but do not have reaction The peroxide and TEMED will destroy the protein (W.E.Hennink, Advanced Drug Delivery Reviews, No. 64, pages 223-226), and the gelation speed is too fast (generally curing within 30 seconds), which is not conducive to molding.

Therefore, the prior art still needs to be improved and developed.

Contents of the invention

In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a kind of anti-period leakage hydrogel material and its preparation method, aiming to solve the problem of unreacted peroxide And the catalyst will destroy the protein, and the speed of gelation is too fast, which is not conducive to the problem of molding.

Realize the technical scheme of the present invention as follows:

A method for preparing an anti-circumferential hydrogel material is provided, comprising the steps of:

Mix the hydrophilic monomers and cross-linking agents for preparing hydrogel materials in proportion and dissolve them in phosphate buffer solution, then add a catalyst composed of vitamin B2 and L-arginine, mix them evenly, and pour them into the mold, at room temperature Cross-linking under ultraviolet light with a wavelength of 300-400nm to obtain a hydrogel material product;

The hydrogel material product is washed with a detergent to remove unreacted monomers and catalysts, and then dried to obtain an anti-peripheral leakage hydrogel material.

The preparation method of the anti-peripheral leakage hydrogel material, wherein, the hydrophilic monomer for preparing the hydrogel material includes acrylic acid, acrylate, methacrylic acid, methacrylate, acrylamide, N-vinyl One or a combination of two or more of pyrrolidones.

The preparation method of the anti-circumferential leakage hydrogel material, wherein, the crosslinking agent includes polyethylene glycol dimethacrylate, polyvinyl alcohol grafted methacrylate, polyacrylic acid grafted methacrylate One or a combination of two or more.

The preparation method of the anti-circumferential leakage hydrogel material, wherein, by mass, the addition ratio of the hydrophilic monomer and the cross-linking agent that is prone to photoinitiated polymerization is (3-6): (0.1-0.56) .

The preparation method of the anti-peripheral leakage hydrogel material, wherein, in terms of mass, in the catalyst composed of vitamin B2 and L-arginine, vitamin B2:L-arginine=2˜16:1.

The preparation method of the anti-peripheral leakage hydrogel material, wherein, in terms of mass, in the catalyst composed of vitamin B2 and L-arginine, vitamin B2:L-arginine=4-8:1.

The preparation method of the anti-circumferential leakage hydrogel material, wherein, at normal temperature, cross-linking is carried out under ultraviolet light with a wavelength of 365nm for 1-3 hours to obtain the hydrogel material product.

The preparation method of the anti-peripheral leakage hydrogel material, wherein, the step of washing the hydrogel material product with alcohol specifically includes: successively washing with 50% alcohol, 75% alcohol and absolute alcohol for at least 1 times, each washing 20 ~ 40min.

The preparation method of the anti-circumferential leakage hydrogel material, wherein, the drying temperature is 30-50°C.

The present invention also provides an anti-peripheral leakage hydrogel material comprising a hydrophilic monomer and a cross-linking agent in a mass ratio of (3-6):(0.1-0.56); wherein, the hydrophilic monomer including one or a combination of two or more of acrylic acid, acrylate, methacrylic acid, methacrylate, acrylamide, N-vinylpyrrolidone; the crosslinking agent includes polyethylene glycol dimethacrylate, One or more combinations of polyvinyl alcohol grafted methacrylate and polyacrylic acid grafted methacrylate.

The present invention provides another anti-peripheral leakage hydrogel material, which is prepared by any one of the above preparation methods.

Beneficial effects: the preparation method of the present invention uses vitamin B2 and L-arginine catalyst system to catalyze the cross-linking reaction, adopts raw materials with good biocompatibility, adopts green synthesis route, has the advantages of simple operation, low cost, The advantages of wide applicability and high controllability. The anti-peripheral leakage hydrogel material prepared by the preparation method of the invention has uniform thickness, good flexibility, fast water absorption and good anti-peripheral leakage effect.

detailed description

The present invention provides an anti-peripheral leakage hydrogel material and its preparation method. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

Compared with the existing biotoxic catalyst system using ammonium persulfate (APS) and tetramethylethylenediamine (TEMED), the present invention uses green vitamin B2 and L-arginine catalyst system for ultraviolet polymerization , the in-situ rapidly expanding anti-peripheral leakage hydrogel sealing material is prepared, which has a good anti-peripheral leakage effect, can prevent blood backflow, further improve the operation effect, increase the success rate of the operation, thereby reducing the risk of heart failure and death of patients.

The preparation method of the anti-circumferential leakage hydrogel material of the present invention comprises steps:

S100. Mix and dissolve the hydrophilic monomer and cross-linking agent for preparing the hydrogel material in proportion to the phosphate buffer solution, then add the catalyst composed of vitamin B2 and L-arginine, mix well and pour it into the mold , at room temperature, cross-linking is carried out under ultraviolet light with a wavelength of 300-400nm to obtain a hydrogel material product; the wavelength of ultraviolet light is preferably 365nm, and can also be 300nm, 320nm, 350nm, or 400nm.

S200. Wash the hydrogel material product with a detergent to remove unreacted monomers and catalysts, and then dry it to obtain an anti-peripheral leakage hydrogel material. The detergent is preferably alcohol, and may also be deionized water or other materials capable of washing the hydrogel material product to remove unreacted monomers and catalysts.

The preparation method of the present invention uses vitamin B2 and L-arginine catalyst system to catalyze the cross-linking reaction, all of which are raw materials with good biocompatibility, adopts a green synthesis route, and has the advantages of simple operation, low cost and universal applicability Wide range and high controllability.

Further, the hydrophilic monomer for preparing the hydrogel material includes but is not limited to one of acrylic acid, acrylate, methacrylic acid, methacrylate, acrylamide, N-vinylpyrrolidone (NVP) or A combination of two or more. The above-mentioned hydrophilic monomers are all hydrophilic monomers that are easy to be polymerized by photoinitiation.

Further, the crosslinking agent of the present invention is polymethacrylate (>2), which includes but not limited to polyethylene glycol dimethacrylate (molecular weight 500D), polyvinyl alcohol grafted methacrylate ( One or a combination of two or more of PVA-GMA), polyacrylic acid (molecular weight: 60,000) grafted methacrylate (PAA-g-GMA).

The hydrophilicity of the monomer and the type of crosslinker have a crucial impact on the water absorption of the resulting hydrogel. As shown in Table 1, Table 1 shows the influence of different polymethacrylate crosslinking agents on the properties of hydrogels. As can be seen from Table 1, Examples 1 to 3 use acrylic acid as a monomer and polyethylene glycol dimethacrylate as a crosslinking agent, compared with the use of polyvinyl alcohol grafted methacrylate and polyacrylic acid grafted methyl Acrylate is used as a crosslinking agent, and the obtained hydrogel material has a high water absorption rate. The water absorption rate of the hydrogel material obtained by the copolymerization of hydroxyethyl methacrylate (HEMA) and N-vinylpyrrolidone monomer and polyvinyl alcohol grafted methacrylate crosslinking agent in Examples 4 and 5 is lower than that of Example 2. This is mainly due to the weaker hydrophilicity of hydroxyethyl methacrylate and N-vinylpyrrolidone than polyacrylic acid.

Table 1. Effect of different polymethacrylate crosslinkers on hydrogel properties

Further, the polyvinyl alcohol-grafted polymethacrylate of the present invention is prepared by the following method: 2 g of polyvinyl alcohol (molecular weight: 80,000, fully hydrolyzed) is dissolved in 150 mL of pure water, and sodium hydroxide is added to adjust the pH=10.5 , and then add 1mL glycidyl methacrylate, react at 50°C for 24h, then precipitate with acetone, and dry in vacuum to obtain polyvinyl alcohol grafted polymethacrylate. The preparation method of polyacrylic acid grafted polymethacrylate is basically the same as that of polyvinyl alcohol grafted polymethacrylate, the difference is that the reaction is carried out under the condition of pH=3.5.

Preferably, on a mass basis, the addition ratio of the hydrophilic monomer prone to photoinitiated polymerization and the crosslinking agent is (3-6): (0.1-0.56). For example, it can be 3:0.1, 4:0.3, 6:0.56.

The amount of cross-linking agent is also an important factor affecting the water absorption rate, as shown in Table 2, and Table 2 is the influence of different cross-linking agent amounts on the water absorption rate of the hydrogel under the conditions of Example 1 (wherein the water absorption rate is measured after 30min) . It can be seen from Table 2 that with the increase of the amount of crosslinking agent, the water absorption rate gradually decreases. In order to obtain the hydrogel with a high water absorption rate, the dosage of the crosslinking agent used in the present invention is 0.1-0.56 g.

Table 2. Effects of different crosslinking agent dosages on hydrogel water absorption under the conditions of Example 1

Preferably, in the step S100, after mixing and dissolving the hydrophilic monomer and the cross-linking agent for preparing the hydrogel material in proportion to the phosphate buffer, first adding NaOH solution to adjust the pH value to neutral, and then adding the Catalyst composed of vitamin B2 and L-arginine. Adding NaOH solution to adjust the pH value to neutral can improve the efficiency of the crosslinking reaction, and help to obtain an anti-circumferential hydrogel material with better performance parameters such as flexibility and water absorption.

Preferably, in terms of mass, in the catalyst composed of vitamin B2 and L-arginine, vitamin B2:L-arginine=2˜16:1. For example, it can be 2:1, 10:1, 16:1.

More preferably, in terms of mass, in the catalyst composed of vitamin B2 and L-arginine, vitamin B2:L-arginine=4˜8:1. For example, it can be 4:1, 6:1, 8:1.

The combination of vitamin B2 and L-arginine is used to generate the initiating active species, so the ratio of the two has a great influence on the initiating efficiency. When the ratio of L-arginine: vitamin B2 is 2:1～16:1 , the monomer conversion was higher than 80%.

Further, in the step S100, the phosphate buffer solution (phosphate buffer saline, PBS) is a phosphate buffer solution with a pH of 7.4.

Further, in the step S100, cross-linking is carried out under ultraviolet light with a wavelength of 365 nm for 1-3 hours at room temperature to obtain a hydrogel material product.

In the present invention, there are still unreacted monomers in the hydrogel prepared by ultraviolet crosslinking. Since monomers such as acrylic acid are soluble in water and ethanol, the unreacted monomers are removed by washing with ethanol solution.

Further, in the step S200, the step of washing the hydrogel material product with alcohol specifically includes: successively washing with 50% alcohol, 75% alcohol and absolute alcohol for at least one time each, and washing for 20 ~40min. For example, wash with 50% alcohol, 75% alcohol and absolute alcohol for 1 time, each time for 30 minutes.

Further, in the step S200, the drying temperature is 30-50°C. For example, it may be 30°C, 40°C, or 50°C.

Based on the above-mentioned preparation method, the present invention also provides an anti-peripheral leakage hydrogel material, which is prepared by the above-mentioned preparation method. The anti-circumferential leakage gel material prepared by the preparation method of the present invention has uniform thickness, good flexibility, fast water absorption speed, and can even rapidly expand to 40 times the original volume in situ, and has a good anti-circumferential leakage effect.

In the invention, hydrogels with different crosslinking and water absorption rates are obtained by adjusting the ratio of the catalyst system and the type and amount of the crosslinking agent.

It should be noted that the chemical reagents in the present invention are analytically pure unless otherwise stated.

The invention adopts infrared spectrum to determine the reaction conversion rate, and screens suitable hydrogel membrane materials through water absorption measurement.

The thickness of the hydrogel material prepared by the invention is less than 300 μm (micron) after drying, and the obtained material is relatively uniform, has good flexibility and fast water absorption speed. The invention is a green synthesis route, all materials used are good biocompatibility, and has the advantages of simple operation, low cost, wide applicability and high controllability.

The present invention adopts the gravimetric method to measure the water absorption rate of the hydrogel, weighs the dried hydrogel (W _dry ), then puts the material in a petri dish, adds deionized water, and takes it out and weighs it after swelling for 10min and 30min. Hydrogel weight (W _wet ), the calculation formula is as follows:

Water absorption (100%)=(W _wet −W _dry )/W _dry .

The present invention is described in detail below with specific embodiment:

Example 1

(1) Dissolve 3.5g of acrylic acid and 0.14g of polyethylene glycol dimethacrylate in 20mL of phosphate buffer solution (pH7.4), add NaOH solution to adjust the pH to neutral, add 50mg of vitamin B2 and 400mg The L-arginine is mixed evenly and poured into a mold, and reacted for 3 hours in an ultraviolet crosslinking instrument with a wavelength of 365nm to obtain a hydrogel material product;

(2), the hydrogel material product obtained in step (1) was washed 3 times with 50%, 75% and absolute alcohol respectively, each time for 30min, to remove unreacted monomers, and then dried at 40°C to obtain anti- Peripheral leaky hydrogel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 10 to 15 times in 10 minutes and 40 to 60 times in 30 minutes, with uniform thickness and good flexibility.

Example 2

(1), add 3.2g of acrylic acid and 0.2g of polyvinyl alcohol grafted polymethacrylate crosslinking agent into 20mL of phosphate (pH7.4), add NaOH solution to adjust the pH value to neutral, add 50mg of vitamin B2 and 400mg of L-arginine was mixed evenly and poured into a mold, and reacted for 2 hours in an ultraviolet crosslinking instrument with a wavelength of 365nm to obtain a hydrogel material product;

(2), the hydrogel material product obtained in step (1) was washed 3 times with 50%, 75% and absolute alcohol respectively, each time for 30 minutes, to remove unreacted monomers, and then dried at 40°C to obtain anti-peripheral Leaky gel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 10 to 15 times in 10 minutes and 30 to 40 times in 30 minutes, with uniform thickness and good flexibility.

Example 3

(1), add 3g of acrylic acid and 0.2g of polyacrylic acid grafted polymethacrylate crosslinking agent to 20mL of phosphate (pH7.4), add NaOH solution to adjust the pH value to neutral, add 50mg of vitamin B2 and 400mg of L-arginine, mixed evenly, poured into a mold, and reacted for 2 hours in an ultraviolet crosslinking instrument with a wavelength of 365nm, to obtain a hydrogel material product;

(2) The hydrogel material product obtained in step (1) was washed once with 50%, 75% and absolute alcohol, respectively, for 40 minutes each time, and then dried at 40° C. to obtain the anti-peripheral leakage hydrogel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 10 to 15 times in 10 minutes and 30 to 40 times in 30 minutes, with uniform thickness and good flexibility.

Example 4

(1), add 5.8g hydroxyethyl methacrylate and 0.25g polyvinyl alcohol grafted polymethacrylate crosslinking agent into 20mL phosphate (pH7.4), add NaOH solution to adjust the pH value to neutral, Add 50mg of vitamin B2 and 400mg of L-arginine, mix evenly, pour into a mold, and react for 2 hours in an ultraviolet crosslinking instrument with a wavelength of 365nm to obtain a hydrogel material product;

(2) The hydrogel material product obtained in step (1) was washed once with 50%, 75% and absolute alcohol respectively, and then dried at 40° C. to obtain the hydrogel material product.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 10 to 15 times in 10 minutes and 20 to 30 times in 30 minutes, with uniform thickness and good flexibility.

Example 5

(1), 5g N-vinylpyrrolidone and 0.25g polyvinyl alcohol grafted polymethacrylate crosslinking agent are added in 20mL PBS (pH7.4), add NaOH solution to adjust the pH value to neutrality, add 50mg vitamin B2 and 400mg of L-arginine was mixed evenly and poured into a mold, and reacted for 3 hours in an ultraviolet crosslinking instrument with a wavelength of 320nm to obtain a hydrogel material product;

(2) The hydrogel material product obtained in step (1) was washed once with 50%, 75% and absolute alcohol respectively, and then dried at 30° C. to obtain the anti-peripheral leakage hydrogel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 10 to 15 times in 10 minutes and 20 to 30 times in 30 minutes, with uniform thickness and good flexibility.

Example 6

(1), 6g N-vinylpyrrolidone and 0.56g polyvinyl alcohol grafted polymethacrylate crosslinking agent are added in 20mL PBS (pH7.4), add NaOH solution to adjust the pH value to neutrality, add 50mg vitamin B2 and 100mg of L-arginine was mixed evenly and poured into a mold, and reacted for 1 hour in an ultraviolet crosslinker with a wavelength of 365nm to obtain a hydrogel material product;

(2) The hydrogel material product obtained in step (1) was washed once with 50%, 75% and absolute alcohol, respectively, for 20 minutes each time, and then dried at 50° C. to obtain the anti-peripheral leakage hydrogel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 5-10 times in 10 minutes and 10-20 times in 30 minutes, with uniform thickness and good flexibility.

Example 7

(1), add 3.2g acrylic acid and 2.6g hydroxyethyl methacrylate and 0.2g polyvinyl alcohol grafted polymethacrylate crosslinking agent to 20mL phosphate (pH7.4), add NaOH solution to adjust the pH value To neutrality, add 50mg of vitamin B2 and 400mg of L-arginine, mix evenly, pour into a mold, and react for 2 hours in a 400nm wavelength ultraviolet crosslinking apparatus to obtain a hydrogel material product;

(2) The hydrogel material product obtained in step (1) was washed with 75% alcohol three times, each time for 30 minutes, to remove unreacted monomers, and then dried at 40° C. to obtain an anti-peripheral leakage hydrogel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 10 to 15 times in 10 minutes and 30 to 40 times in 30 minutes, with uniform thickness and good flexibility.

Example 8

(1), add 5.8g N-vinylpyrrolidone, 0.1g polyvinyl alcohol grafted polymethacrylate and 0.1g polyethylene glycol dimethacrylate crosslinking agent to 20mL phosphate (pH7.4) , adding NaOH solution to adjust the pH value to neutral, adding 50mg of vitamin B2 and 400mg of L-arginine, mixing evenly, pouring into the mold, and reacting for 2 hours in a UV crosslinking instrument with a wavelength of 400nm to obtain a hydrogel material product ;

(2) The hydrogel material product obtained in step (1) was washed with deionized water for 5 times, each time for 30 minutes, to remove unreacted monomers, and then dried at 40° C. to obtain an anti-peripheral leakage hydrogel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 10 to 15 times in 10 minutes and 30 to 40 times in 30 minutes, with uniform thickness and good flexibility.

Example 9

(1), add 20mL phosphate ( pH7.4), add NaOH solution to adjust the pH value to neutral, add 50mg of vitamin B2 and 400mg of L-arginine, mix evenly, pour into the mold, react in a 350nm wavelength ultraviolet crosslinker for 2h, and obtain Hydrogel material products;

(2) The hydrogel material product obtained in step (1) was washed with 75% alcohol three times, each time for 30 minutes, to remove unreacted monomers, and then dried at 40° C. to obtain an anti-peripheral leakage hydrogel material.

The water leakage prevention gel material prepared in this example is translucent, with a water absorption rate of 5-10 times in 10 minutes and 10-20 times in 30 minutes, with uniform thickness and good flexibility.

In summary, the anti-peripheral leakage hydrogel material and its preparation method provided by the embodiment of the present invention, the preparation method uses vitamin B2 and L-arginine catalyst system to catalyze the cross-linking reaction, all of which are biological phase The raw material with good capacity adopts a green synthesis route, which has the advantages of simple operation, low cost, wide applicability and high controllability. The anti-peripheral leakage hydrogel material prepared by the preparation method of the invention has uniform thickness, good flexibility, fast water absorption and good anti-peripheral leakage effect.

It should be understood that the application of the present invention is not limited to the above examples, and those skilled in the art can make improvements or transformations according to the above descriptions, and all these improvements and transformations should belong to the protection scope of the appended claims of the present invention.

Claims (11)

1. a kind of preparation method of anti-all leak gel rubber materials, it is characterised in that including step：

The hydrophilic monomer and crosslinking agent that prepare hydrogel material are mixed in proportion and are dissolved in phosphate buffer, then add by The catalyst of vitamin B2 and L-arginine composition, is poured into mould after being well mixed, under normal temperature, in 300~400nm wavelength It is crosslinked under ultraviolet light, obtains hydrogel material product；

The hydrogel material product is washed with detergent, unreacted monomer and catalyst is removed, then dries, obtain To anti-all leak gel rubber materials.

2. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that described to prepare hydrogel The hydrophilic monomer of material includes acrylic acid, acrylate, methacrylic acid, methacrylate, acrylamide, N- vinyl The combination of one or two and the above in pyrrolidones.

3. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that the crosslinking agent includes In polyethylene glycol dimethacrylate, polyvinyl alcohol graft copolymerized methacrylate, polyacrylic acid grafted methacrylate The combination of the one or two kinds of and above.

4. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that by mass, described The adding proportion of the hydrophilic monomer and crosslinking agent that are easy to light initiation polymerization is (3~6)：(0.1~0.56).

5. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that by mass, described In the catalyst be made up of vitamin B2 and L-arginine, vitamin B2：L-arginine=2~16：1.

6. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that by mass, described In the catalyst be made up of vitamin B2 and L-arginine, vitamin B2：L-arginine=4~8：1.

7. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that under normal temperature, in 365nm 1~3h of crosslinking is carried out under the ultraviolet light of wavelength, hydrogel material product is obtained.

8. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that by the water-setting glue material Expect that the step of product is with ethanol wash is specifically included：Successively use 50% alcohol, 75% alcohol and absolute alcohol are respectively washed extremely It is few 1 time, 20~40min is washed every time.

9. the preparation method of anti-all leak gel rubber materials according to claim 1, it is characterised in that the drying temperature is 30~50 DEG C.

10. a kind of anti-all leak gel rubber materials, it is characterised in that including being calculated as in mass ratio (3~6)：The parent of (0.1~0.56) Aqueous monomers and crosslinking agent；Wherein, described hydrophilic monomer includes acrylic acid, acrylate, methacrylic acid, metering system The combination of one or two and the above in acid esters, acrylamide, NVP；The crosslinking agent includes poly- second two Alcohol dimethylacrylate, polyvinyl alcohol graft copolymerized methacrylate, one kind in polyacrylic acid grafted methacrylate or Two kinds and the combination of the above.

11. a kind of anti-all leak gel rubber materials, it is characterised in that using the preparation method as described in any one of claim 1~9 It is made.