CN106955092B - Method and equipment for measuring pulse distribution - Google Patents

Abstract

The present application discloses a method and device for measuring pulse distribution. The method includes: constructing a speckle interference optical path, wherein the speckle interference optical path includes an arterial part of the pulse beating of a measured organism; The speckle interferes with the optical path to determine the pulse distribution information of the arterial part, wherein the pulse distribution information includes: pulse spatial distribution information and/or pulse time distribution information. According to the method and device of the embodiments of the present application, the measurement of pulse distribution can be realized, and effective and objective pulse data can be provided for clinical diagnosis.

Description

Method and device for measuring pulse distribution

technical field

The present application relates to the technical field of full-field light detection, and in particular, to a method and device for measuring pulse distribution.

Background technique

In TCM, pulse-taking, also known as pulse-cutting, means that TCM physicians sense the pulse beat by pressing the patient's arteries, identify the pulse, and then diagnose diseases based on the pulse.

Traditional Chinese medicine practitioners often analyze pulse status from four aspects: pulse position, pulse number, pulse shape, and pulse potential. Pulse position refers to the position and length of the pulse, pulse number refers to the frequency and rhythm of the pulse, pulse shape refers to the width and other forms of the pulse, and pulse potential refers to the strength and smoothness of the pulse. Pulse is a reflection of human body functions, and different pulses have corresponding disease ranges.

The human pulse is an unstable vibration with a small amplitude. Pulse measuring instruments in the prior art, such as electronic pulse measuring instruments or photoelectric pulse measuring instruments, can only measure the vibration frequency information of the pulse (that is, the pulse number), and cannot measure other than the vibration frequency information of the pulse. Additional pulse information.

SUMMARY OF THE INVENTION

In view of this, embodiments of the present application provide a method and device for measuring pulse distribution, which are used to solve the technical problem in the prior art that other pulse information other than the vibration frequency information of the pulse cannot be measured, and provide an objective for clinical diagnosis. Pulse distribution data.

Embodiments of the present application provide a method for measuring pulse distribution, including:

constructing a speckle interference light path, wherein the speckle interference light path includes an arterial part where the pulse of the tested organism is beating;

According to the speckle interference optical path, the pulse distribution information of the arterial part is determined, wherein the pulse distribution information includes: pulse spatial distribution information and/or pulse time distribution information.

Optionally, determining the pulse spatial distribution information of the arterial site according to the speckle interference optical path, including:

acquiring a first speckle image for the arterial site at a first time, and acquiring a second speckle map for the arterial site at a second time;

determining a first phase quantity corresponding to the first speckle pattern, and determining a second phase quantity corresponding to the second speckle pattern;

According to the first phase quantity and the second phase quantity, the pulse spatial distribution information of the arterial part at the second moment is determined.

Optionally, determining the pulse time distribution information of the arterial site according to the speckle interference optical path, including:

collecting multiple speckle images for the arterial site within a preset time period;

determining multiple phase quantities corresponding to the multiple speckle patterns;

According to the plurality of phase quantities, pulse time distribution information of the arterial part within the preset time period is determined.

Optionally, the speckle interference light path is a space carrier digital speckle interference light path, wherein the space carrier digital speckle interference light path includes a laser, a light splitting element, a beam expanding element, a diaphragm, An imaging element and an image sensor for constructing the space carrier digital speckle interference optical path, including:

the laser emits laser light;

The laser light is reflected by the spectroscopic element and the reference light that meets the set angle is incident on the image sensor;

The laser beam is transmitted to the beam expanding element through the beam splitting element, and the beam expanding element emits the laser beam expanding and then illuminates the arterial part, and the first object light reflected by the arterial part is incident on the arterial part. the diaphragm, which is transmitted to the imaging element via the diaphragm, wherein the diaphragm is used to make the spatial frequency of the first object light meet a set range;

The second object light obtained by imaging by the imaging element is incident on the image sensor;

The second object light and the reference light interfere on the surface of the image sensor.

Optionally, the method further includes:

According to the pulse spatial distribution information and/or the pulse time distribution information, the health status of the measured organism is analyzed.

The embodiment of the present application further provides a pulse distribution measurement device, including: a speckle interference optical path unit and a determination unit, wherein:

The speckle interference optical path unit is used to illuminate the arterial part of the pulse beating of the tested organism;

A determination unit, configured to determine the pulse distribution information of the arterial part, wherein the pulse distribution information includes: pulse spatial distribution information and pulse time distribution information.

The above-mentioned at least one technical solution adopted in the embodiments of the present application can achieve the following beneficial effects:

By constructing the speckle interference optical path of the arterial part containing the pulse beating of the tested organism, and then determining the pulse spatial distribution information and/or pulse time distribution information of the arterial part according to the speckle interference optical path, so as to realize the pulse distribution information. It can provide effective and objective pulse data for clinical diagnosis.

Description of drawings

The drawings described herein are used to provide further understanding of the present application and constitute a part of the present application. The schematic embodiments and descriptions of the present application are used to explain the present application and do not constitute an improper limitation of the present application. In the attached image:

1 is a schematic flowchart of a method for measuring pulse distribution according to an embodiment of the present application;

2 is a schematic diagram of an optical path of a space carrier digital speckle interference optical path provided by an embodiment of the present application;

3(a) is a schematic diagram of a speckle image of a target object provided by an embodiment of the present application;

3(b) is a schematic diagram of a spectrum distribution diagram of a target object provided by an embodiment of the present application;

FIG. 3(c) is a schematic diagram of a filtered spectrum of a target object according to an embodiment of the present application;

FIG. 3(d) is a schematic diagram of a deformation phase diagram of a target object provided by an embodiment of the present application;

FIG. 4 is a schematic structural diagram of a pulse distribution measurement device provided by an embodiment of the present application.

Detailed ways

In order to achieve the purpose of the present application, the embodiments of the present application provide a method and device for measuring pulse distribution. , determine the pulse space distribution information and/or pulse time distribution information of the arterial part, realize the measurement of the pulse distribution, and provide effective and objective pulse data for clinical diagnosis.

The technical solutions of the present application will be clearly and completely described below with reference to the specific embodiments of the present application and the corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

The technical solutions provided by the embodiments of the present application will be described in detail below with reference to the accompanying drawings.

Example 1

FIG. 1 is a schematic flowchart of a method for measuring pulse distribution according to an embodiment of the present application. The method can be as follows.

Step 11: Construct the speckle interference light path.

Among them, the speckle interference optical path includes the arterial part where the pulse of the living body to be measured is beating.

In step 11 , a speckle interference optical path including the arterial part of the pulse beating of the living body is constructed, and preparations are made for further measuring the pulse distribution according to the speckle interference optical path.

Wherein, the arterial part of the measured body refers to the part where the pulse of the measured body is obvious and easy to measure, such as the radial artery of the human body near the wrist, which is not specifically limited here.

Optionally, the speckle interference light path is a space carrier digital speckle interference light path.

Pulse beat is a kind of unstable vibration with small amplitude, which belongs to dynamic deformation. The space carrier digital speckle interference optical path can measure the dynamic deformation of pulse, and then obtain the corresponding spatial distribution and time distribution of pulse.

The space carrier digital speckle interference optical path generates a space carrier signal by tilting the reference light with the optical axis at a set angle. After Fourier transform is performed on the measured speckle pattern, the high-frequency part and the low-frequency part representing the background light containing the deformation information of the target object (the pulsed arterial part of the measured organism) are obtained. The introduction makes the high frequency part in the spectrum shift the frequency to realize the separation from the low frequency part, so by extracting the high frequency part containing the deformation information of the target object and then solving the interference phase, and finally according to the relationship between the interference phase and the deformation variable of the target object, Determines the amount of deformation of the target object.

It should be noted that the space carrier digital speckle interference optical path may be a space optical path built in a space environment, or may be an optical path integrated in a measuring instrument, which is not specifically limited here.

FIG. 2 is a schematic diagram of an optical path of a space carrier digital speckle interference optical path provided by an embodiment of the present application.

As shown in Figure 2, optionally, the space carrier digital speckle interference optical path includes lasers, beam splitting elements, beam expanding elements, diaphragms, imaging elements and image sensors that satisfy the set coherence length value to construct the space carrier digital speckle Interfering optical paths, including:

Laser emits laser light;

The laser is reflected by the spectroscopic element and the reference light that meets the set angle is incident on the image sensor;

The laser is transmitted to the beam expanding element through the beam splitting element, and the beam expanding element emits the laser beam expanding and then illuminates the arterial part, the first object light obtained by the reflection of the arterial part is incident on the diaphragm, and is transmitted to the imaging element through the diaphragm, wherein , the diaphragm is used to make the spatial frequency of the first object light meet the set range;

The second object light obtained by imaging by the imaging element is incident on the image sensor;

The second object light interferes with the reference light on the surface of the image sensor.

Among them, the set angle (α) satisfies the formula:

Among them, λ represents the wavelength of laser light emitted by the laser, f _M represents the spatial frequency of the first object light, and f _P represents the time sampling frequency of the image sensor.

It should be noted that setting the coherence length value means that the laser emitted by the laser can ensure that the reference light and the second object light interfere with each other.

In the embodiment of the present application, the time sampling frequency of the image sensor is based on satisfying the sampling frequency, and the specific value may be determined according to the actual situation, which is not specifically limited here.

It should be noted that, in order to determine the pulse distribution of the arterial site according to the spatial carrier digital speckle interference optical path, the spatial frequency f _M of the first object light satisfies the set range:

Since the diaphragm is used to make the spatial frequency of the first object light meet the set range, the aperture size of the diaphragm satisfies:

Among them, d represents the distance from the diaphragm to the imaging element.

Optionally, the light-splitting element is a tunable light-splitting plate.

In addition to the adjustable beam splitter plate, the beam splitting element can also be an adjustable beam splitter, and other optical elements capable of beam splitting can also be used, which is not specifically limited here.

Optionally, the beam expander element is a microscope objective.

In addition to the microscope objective lens, the beam expander can also use a plano-concave lens, and other optical elements capable of beam expansion can also be used, which is not specifically limited here.

Preferably, the imaging element is a plano-convex lens.

In addition to a plano-convex lens, an industrial lens can also be used as the imaging element, and other optical elements capable of imaging can also be used, which is not specifically limited here.

In the embodiment of the present application, in addition to the space carrier digital speckle interference light path, the speckle interference light path may also use a 4+1 time phase shift digital speckle interference light path, and other speckle interference light paths capable of measuring dynamic deformation may also be used. The speckle interference optical path is not specifically limited here.

Step 12: Determine the pulse distribution information of the arterial site according to the speckle interference optical path.

The pulse distribution information includes: pulse spatial distribution information and/or pulse time distribution information.

In step 12, according to the speckle interference optical path constructed in step 11, the pulse spatial distribution information and/or pulse time distribution information of the arterial part of the pulse beating of the measured organism is determined.

Optionally, according to the speckle interference optical path, the pulse spatial distribution information of the arterial site is determined. Specifically, in the first step, the first speckle map for the arterial site is collected at the first moment, and the arterial site is collected at the second moment. of the second speckle pattern.

For example, taking the space carrier digital speckle interference optical path as an example, since the second object light obtained by imaging by the imaging element is obtained after imaging the artery, the second object light and the reference light interfere on the surface of the image sensor, therefore, An interference speckle pattern (hereinafter referred to as a speckle pattern) for the arterial part can be collected by the image sensor.

The image sensor acquires a first speckle pattern and a second speckle pattern for the arterial site at a first time instant and a second time instant, respectively.

In the second step, the first phase quantity corresponding to the first speckle pattern is determined, and the second phase quantity corresponding to the second speckle pattern is determined.

In the third step, according to the first phase quantity and the second phase quantity, determine the pulse spatial distribution information of the arterial part at the second moment.

FIG. 3( a ) is a schematic diagram of a first speckle pattern of a target object according to an embodiment of the present application.

Still taking the above space carrier digital speckle interference optical path as an example, Fourier transform is performed on the first speckle pattern (for example, Fig. 3(a)) corresponding to the target object (for example, the arterial part) to obtain the first speckle Fig. 3(b) is a schematic diagram of a spectrum distribution diagram of a target object provided by an embodiment of the present application.

The spectral distribution corresponding to the first speckle pattern is:

I(f _x )=FT[I(x)]=A(f _x )+B(f _x )+C(f _x ),

Among them, I(f _x ) represents the spectral distribution corresponding to the first speckle pattern, I(x) represents the light intensity of the target object, A(f _x ) and B(f _x ) represent the two conjugated high-frequency parts, C(f _x ) represents the low-frequency part, f _x represents the frequency domain coordinate, x represents the one-dimensional space coordinate, and the symbol FT represents the Fourier transform.

In the spectrum distribution plot:

A(f _x )=FT[O(x)R ^* (x)];

B(f _x )=FT[R(x)O ^* (x)];

C(f _x )=FT[|R(x)| ² +|O(x)| ² ].

Among them, R(x) represents the light intensity of the object light of the target object, O(x) represents the light intensity of the reference light, and the symbol * represents the conjugate.

After spectral window filtering, one of the high-frequency parts A(f _x ) is obtained, and the other two spectral parts B(f _x ) and C(f _x ) are filtered out. FIG. 3( c ) is the target object provided by the embodiment of the present application Schematic of the filtered spectrum.

Inverse Fourier transform is performed on the filtered spectrum, and the expression containing the first phase quantity of the target object is obtained according to the following formula:

表示目标对象的第一相位量，A(x)表示目标对象在得到第一散斑图时的干涉光的光强信息，符号IFT表示傅立叶逆变换。where A _IFT represents an expression containing the first phase quantity of the target object,

represents the first phase quantity of the target object, A(x) represents the light intensity information of the interference light of the target object when the first speckle pattern is obtained, and the symbol IFT represents the inverse Fourier transform.

Similarly, for the second speckle pattern corresponding to the target object, the expression containing the second phase quantity of the target object can also be obtained by performing the operations of the above Fourier transform, filtering processing and inverse Fourier transform:

表示目标对象的第二相位量，A'(x)表示目标对象在得到第二散斑图时的干涉光的光强信息，符号IFT表示傅立叶逆变换。where A _IFT ' represents an expression containing the second phase quantity of the target object,

represents the second phase quantity of the target object, A'(x) represents the light intensity information of the interference light of the target object when the second speckle pattern is obtained, and the symbol IFT represents the inverse Fourier transform.

After obtaining the expression containing the first phase quantity of the target object and the expression containing the second phase quantity of the target object, according to the expression containing the first phase quantity of the target object and the expression containing the second phase quantity of the target object The following formula is used to obtain the deformation information of the target object.

Among them, Im and Re represent the imaginary part and the real part, respectively, and the symbol * represents the conjugation.

FIG. 3( d ) is a schematic diagram of a deformation phase diagram of a target object according to an embodiment of the present application.

According to the deformation information of the target object, determine the spatial distribution information of the target object at the second moment, including:

According to the deformation information of the target object, the spatial distribution information of the target object at the second moment is determined by the following formula:

表示目标对象的空间分布信息，即目标对象的各个位置在第二时刻的形变分布，

表示目标对象的形变信息，

表示位移敏感矢量，

k_i表示照亮动脉部位方向的单位矢量，k_o表示第一物光方向的单位矢量，λ表示激光器发射激光的波长。in,

Represents the spatial distribution information of the target object, that is, the deformation distribution of each position of the target object at the second moment,

Represents the deformation information of the target object,

represents the displacement-sensitive vector,

k _i represents the unit vector in the direction of the illuminated arterial site, k _o represents the unit vector in the direction of the first object light, and λ represents the wavelength of the laser emitted by the laser.

It should be noted that the target object represents the arterial part of the measured body's pulse, that is, the above-described scheme is used to determine the pulse spatial distribution information of the arterial part of the measured body.

Optionally, the pulse time distribution information of the arterial part is determined according to the speckle interference optical path. Specifically, in the first step, a plurality of speckle images for the arterial part are collected within a preset time period.

The image sensor acquires multiple speckle images for the arterial site within a preset time period.

It should be noted that the number of the multiple speckle patterns is related to the preset duration and the time sampling frequency of the image sensor.

For example, the time sampling frequency of the image sensor is 75 frames/second, the preset duration is 10 seconds, and the number of multiple speckle images acquired within the preset duration of 10 seconds is 750.

In the second step, multiple phase quantities corresponding to multiple speckle patterns are determined.

Third, according to a plurality of phase quantities, the pulse time distribution information of the arterial part within the preset time period is determined.

Still taking the above space carrier digital speckle interference optical path as an example, through the space carrier method, the speckle is determined according to the speckle diagram of the target object as described in the above Figures 3(a), 3(b) and 3(c). By operating the phase quantities corresponding to the image, determine multiple phase quantities corresponding to the multiple speckle patterns collected for the arterial site; and determine the deformation information of the target object according to the first phase quantity and the second phase quantity as described above operation, according to any two adjacent phase quantities in the plurality of phase quantities, to determine a plurality of pulse deformation information of the arterial part.

根据相位量b和相位量c，确定动脉部位的第二脉搏形变信息

根据相位量c和相位量d，确定动脉部位的第三脉搏形变信息

For example, 4-radial speckle patterns are acquired for the arterial site A within a preset time period, and 4 phase quantities a, b, c, and d corresponding to the 4 speckle patterns are determined. According to the phase quantity a and the phase quantity b, the first pulse deformation information of the arterial part is determined

According to the phase quantity b and the phase quantity c, the second pulse deformation information of the arterial part is determined

According to the phase quantity c and the phase quantity d, the third pulse deformation information of the arterial part is determined

It should be noted that the method of determining the multiple phase quantities corresponding to the multiple speckle patterns can be the space carrier method, the 4+1 time phase shift method, or other methods that can measure dynamic deformation, which are not described here. Specific restrictions.

For example, when the 4+1 time phase shift method is used to determine multiple phase quantities, first, four initial speckle images for the arterial site are collected by the four-step phase shift method; and finally, according to any one of the multiple speckle images and the four initial speckle images, a time phase shift algorithm is used to determine multiple phase quantities corresponding to the multiple speckle images.

Through the method of determining the deformation distribution of the target object based on the deformation information of the target object described in FIG. 3( d ), a plurality of pulse deformation distributions of the arterial site are determined.

Still taking the above arterial part A as an example, the first pulse deformation distribution is determined according to the first pulse deformation information; the second pulse deformation distribution is determined according to the second pulse deformation information; and the third pulse deformation distribution is determined according to the third pulse deformation information .

The first pulse deformation distribution, the second pulse deformation distribution and the third pulse deformation distribution together constitute the pulse time distribution information of the arterial part within the preset time period.

In an optional embodiment of the present application, the method further includes:

According to the pulse spatial distribution information and/or the pulse time distribution information, the health status of the measured organism is analyzed.

The pulse position of the pulse can be obtained according to the pulse space distribution information of the arterial part of the tested organism; the pulse number of the pulse can be obtained according to the pulse time distribution information of the arterial part of the tested organism; the arterial part of the tested organism can be integrated The pulse spatial distribution information and pulse time distribution information can be obtained, and the pulse shape and pulse potential of the pulse can be obtained. According to the pulse information such as pulse position, pulse number, pulse shape, pulse potential, etc., the health status of the tested organism can be analyzed.

According to the technical solutions described in the embodiments of the present application, by constructing a speckle interference optical path of the arterial part containing the pulse beating of the organism under test, and then according to the speckle interference optical path, the pulse spatial distribution information and/or the arterial part can be determined. Or pulse time distribution information, realize the measurement of pulse distribution, and provide effective and objective pulse data for clinical diagnosis.

Example 2

FIG. 4 is a schematic structural diagram of a pulse deformation measurement device provided by an embodiment of the application. The device 400 includes: a speckle interference optical path unit 401 and a determination unit 402, wherein:

The speckle interference optical path unit 401 is used to illuminate the arterial part of the pulse beating of the tested organism;

The determining unit 402 is configured to determine pulse distribution information of the arterial site, wherein the pulse distribution information includes: pulse spatial distribution information and/or pulse time distribution information.

Optionally, the determining unit 402 determines the pulse spatial distribution information of the arterial site, including:

acquiring a first speckle image for the arterial site at a first time instant, and acquiring a second speckle map for the arterial site at a second time instant;

determining a first phase quantity corresponding to the first speckle pattern, and determining a second phase quantity corresponding to the second speckle pattern;

According to the first phase quantity and the second phase quantity, the pulse spatial distribution information of the arterial part at the second moment is determined.

Optionally, the determining unit 402 determines the pulse time distribution information of the arterial site, including:

Acquire multiple speckle images for the arterial site within a preset time period;

Determine multiple phase quantities corresponding to multiple speckle patterns;

According to the multiple phase quantities, the pulse time distribution information of the arterial part within the preset time period is determined.

Optionally, the speckle interference optical path unit 401 is a spatial carrier digital speckle interference optical path unit, wherein the spatial carrier digital speckle interference optical path unit includes a laser that satisfies the set coherence length value, a light splitting element, a beam expanding element, a light diaphragms, imaging elements, and image sensors, including:

Laser emits laser light;

The laser is reflected by the spectroscopic element and the reference light that meets the set angle is incident on the image sensor;

The laser is transmitted to the beam expanding element through the beam splitting element, and the beam expanding element illuminates the arterial part after expanding the laser beam, and the first object light reflected by the arterial part is incident on the diaphragm, and is transmitted to the imaging element through the diaphragm, wherein, The diaphragm is used to make the spatial frequency of the first object light meet the set range;

The second object light obtained by imaging by the imaging element is incident on the image sensor;

The second object light interferes with the reference light on the surface of the image sensor.

Optionally, the device 400 further includes: an analysis unit, wherein:

The analyzing unit is configured to analyze the health status of the measured organism according to the pulse spatial distribution information and/or the pulse time distribution information.

According to the pulse distribution measuring device, the speckle interference optical path unit is used for illuminating the arterial part of the pulse beating of the measured body; the determining unit is used for determining the pulse space distribution information and/or Pulse time distribution information, realize the measurement of pulse distribution, and provide effective and objective pulse data for clinical diagnosis.

As will be appreciated by one skilled in the art, embodiments of the present invention may be provided as a method, system, or computer program product. Accordingly, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present invention may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, etc.) having computer-usable program code embodied therein.

The present invention is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each flow and/or block in the flowchart illustrations and/or block diagrams, and combinations of flows and/or blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to the processor of a general purpose computer, special purpose computer, embedded processor or other programmable data processing device to produce a machine such that the instructions executed by the processor of the computer or other programmable data processing device produce Means for implementing the functions specified in a flow or flow of a flowchart and/or a block or blocks of a block diagram.

These computer program instructions may also be stored in a computer readable memory capable of directing a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer readable memory result in an article of manufacture comprising instruction means, the instructions The apparatus implements the functions specified in the flow or flow of the flowcharts and/or the block or blocks of the block diagrams.

These computer program instructions can also be loaded on a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that The instructions provide steps for implementing the functions specified in the flow or blocks of the flowcharts and/or the block or blocks of the block diagrams.

In a typical configuration, a computing device includes one or more processors (CPUs), input/output interfaces, network interfaces, and memory.

Memory may include non-persistent memory in computer readable media, random access memory (RAM) and/or non-volatile memory in the form of, for example, read only memory (ROM) or flash memory (flash RAM). Memory is an example of a computer-readable medium.

Computer-readable media includes both persistent and non-permanent, removable and non-removable media, and storage of information may be implemented by any method or technology. Information may be computer readable instructions, data structures, modules of programs, or other data. Examples of computer storage media include, but are not limited to, phase-change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read only memory (ROM), Electrically Erasable Programmable Read Only Memory (EEPROM), Flash Memory or other memory technology, Compact Disc Read Only Memory (CD-ROM), Digital Versatile Disc (DVD) or other optical storage, Magnetic tape cartridges, magnetic tape magnetic disk storage or other magnetic storage devices or any other non-transmission medium that can be used to store information that can be accessed by a computing device. As defined herein, computer-readable media does not include transitory computer-readable media, such as modulated data signals and carrier waves.

It should also be noted that the terms "comprising", "comprising" or any other variation thereof are intended to encompass a non-exclusive inclusion such that a process, method, article or device comprising a series of elements includes not only those elements, but also Other elements not expressly listed, or which are inherent to such a process, method, article of manufacture, or apparatus are also included. Without further limitation, an element qualified by the phrase "comprising a..." does not preclude the presence of additional identical elements in the process, method, article of manufacture or device that includes the element.

It will be appreciated by those skilled in the art that the embodiments of the present application may be provided as a method, a system or a computer program product. Accordingly, the present application may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present application may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, etc.) having computer-usable program code embodied therein.

The above descriptions are merely examples of the present application, and are not intended to limit the present application. Various modifications and variations of this application are possible for those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this application shall be included within the scope of the claims of this application.

Claims (5)

1. a measuring method of pulse distribution, is characterized in that, comprises: Constructing a speckle interference optical path, wherein the speckle interference optical path includes the pulsed arterial part, laser, beam splitting element, beam expanding element, imaging element and image sensor of the tested organism; constructing the speckle interference optical path includes: : the laser emits laser light; The laser light is reflected by the spectroscopic element to obtain reference light, and the reference light is incident on the image sensor; The laser beam is transmitted to the beam expanding element through the beam splitting element, the beam expanding element emits the laser beam expanding and then illuminates the arterial part, and is reflected by the arterial part to obtain the first object light, and the The first object light is incident on the imaging element, and the second object light obtained by imaging by the imaging element is incident on the image sensor; the second object light and the reference light interfere on the surface of the image sensor; Determine the pulse distribution information of the arterial part according to the speckle interference optical path, wherein the pulse distribution information includes: pulse spatial distribution information and pulse time distribution information; Wherein, determining the pulse spatial distribution information of the arterial site according to the speckle interference optical path, including: acquiring a first speckle image for the arterial site at a first time, and acquiring a second speckle map for the arterial site at a second time; determining a first phase quantity corresponding to the first speckle pattern, and determining a second phase quantity corresponding to the second speckle pattern; According to the first phase amount and the second phase amount, determine the pulse space distribution information of the arterial part at the second moment; Wherein, according to the speckle interference optical path, the pulse time distribution information of the arterial part is determined, including: collecting multiple speckle images for the arterial site within a preset time period; determining multiple phase quantities corresponding to the multiple speckle patterns; According to the plurality of phase quantities, pulse time distribution information of the arterial part within the preset time period is determined. 2 . The method according to claim 1 , wherein the speckle interference optical path is a spatial carrier digital speckle interference optical path, wherein the laser is a laser satisfying a set coherence length value and is incident on the image. 3 . The reference light of the sensor is the reference light that satisfies the set angle; the space carrier digital speckle interference light path also includes a diaphragm; The first object light incident on the imaging element includes: The first object light reflected by the arterial part is incident on the diaphragm, and is transmitted to the imaging element through the diaphragm, wherein the diaphragm is used to make the spatial frequency of the first object light meet the setting range. 3. A measurement device for pulse distribution, characterized in that the device comprises: a speckle interference optical path unit and a determination unit, wherein: The speckle interference optical path unit is used to illuminate the arterial part of the pulse beating of the tested organism; Wherein, the speckle interference optical path unit includes a laser, a light splitting element, a beam expanding element, an imaging element and an image sensor; constructing the speckle interference optical path includes: The laser light is reflected by the spectroscopic element to obtain reference light, and the reference light is incident on the image sensor; The laser beam is transmitted to the beam expanding element through the beam splitting element, the beam expanding element emits the laser beam expanding and then illuminates the arterial part, and is reflected by the arterial part to obtain the first object light, and the The first object light is incident on the imaging element, and the second object light obtained by imaging by the imaging element is incident on the image sensor; the second object light and the reference light interfere on the surface of the image sensor; a determining unit, configured to determine the pulse distribution information of the arterial part, wherein the pulse distribution information includes: pulse spatial distribution information and pulse time distribution information; Wherein, the determining unit determines the pulse spatial distribution information of the arterial part, including: acquiring a first speckle image for the arterial site at a first time, and acquiring a second speckle map for the arterial site at a second time; determining a first phase quantity corresponding to the first speckle pattern, and determining a second phase quantity corresponding to the second speckle pattern; According to the first phase amount and the second phase amount, determine the pulse space distribution information of the arterial part at the second moment; Wherein, the determining unit determines the pulse time distribution information of the arterial part, including: collecting multiple speckle images for the arterial site within a preset time period; determining multiple phase quantities corresponding to the multiple speckle patterns; According to the plurality of phase quantities, time distribution information of the arterial part within the preset time period is determined. 4. The device according to claim 3, wherein the speckle interference optical path unit is a spatial carrier digital speckle interference optical path unit, wherein the laser is a laser that satisfies the set coherence length value, and is incident on the The reference light of the image sensor is the reference light that satisfies the set angle; the space carrier digital speckle interference optical path unit also includes a diaphragm; The first object light incident on the imaging element includes: The first object light reflected by the arterial part is incident on the diaphragm, and is transmitted to the imaging element through the diaphragm, wherein the diaphragm is used to make the spatial frequency of the first object light meet the setting range. 5. The device according to any one of claims 3-4, wherein the device further comprises: an analysis unit, wherein: An analysis unit, configured to analyze the health status of the measured organism according to the pulse spatial distribution information and/or the pulse time distribution information.

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