CN106938046A - A kind of antibacterial peptide complex enzyme oral spray - Google Patents
A kind of antibacterial peptide complex enzyme oral spray Download PDFInfo
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- CN106938046A CN106938046A CN201710156218.XA CN201710156218A CN106938046A CN 106938046 A CN106938046 A CN 106938046A CN 201710156218 A CN201710156218 A CN 201710156218A CN 106938046 A CN106938046 A CN 106938046A
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- antibacterial peptide
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- lysozyme
- buffer solution
- complex enzyme
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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Abstract
A kind of antibacterial peptide complex enzyme oral spray, it is characterised in that：The spray is made up of by mass percentage following composition：Main component：Antibacterial peptide 2 8%, lysozyme 15 30%；Auxiliary material：Xylitol 5 7%, buffer solution 3 8%, sodium chloride 0.5~1%, bleeding agent 2 6%, remaining is the alkalescent water that ph values are 7.3~7.5；The buffer solution is potassium dihydrogen phosphate, and bleeding agent is AEO.The spray of the present invention is using antibacterial peptide and combines lysozyme as Main Ingredients and Appearance; the effectively biotic component such as buffer solution, bleeding agent is equipped with to be composited; by atomization, by the conversion of the macromolecular of spray of the present invention be small molecule in, add medicine kill germ activity; inflammation of upper respiratory tract can effectively be controlled; the beneficial bacterium in body, good stability are protected, and will not be developed immunity to drugs; and due to being bion oral spray, have no toxic side effect.
Description
Technical field
Spray is atomized the invention belongs to the respiratory system for preventing and controlling canker sore, rhinitis, pharyngitis bronchitis.
Background technology
Pernicious gas in air pollution, such as sulfur dioxide, nitrogen dioxide etc. are directly entered human body, and harmful to human is good for
Health；On the other hand, the harmful substances such as the microorganism, the heavy metal that are mingled with gray haze are entered in vivo along with solid particulate matter,
Huge hidden danger can be carried out to health care belt.Among these, breathing problem " standing in the breach ".Bacterium in dust, air in air and
The pollutants such as virus, are attached on these water droplets, and people are in daily life and trip, the breathing that these materials can be to human body
Road produces influence, may cause acute upper respiratory infection（Flu）, acute tracheobronchitis and pneumonia, asthma attack,
Induce or aggravate chronic bronchitis etc..Particularly child's respiratory tract nose, trachea-bronchial epithelial cell mucous membrane are tender, and alveolar number compared with
Few, elastic fibers development is poor, and interstitial development is vigorous, is more vulnerable to the infection of Respirovirus.People is in the greasy weather for a long time,
The generation of tracheitis, laryngitis, pneumonia, asthma, rhinitis, eye conjunctivitis and anaphylactia can be caused, to child, teen-age life
Long development and constitution have a certain impact.In addition, foggy weather air quality is poor, the poor diabetic pole of resistance has
It is likely to occur lung and tracheae infection and aggravates the state of an illness.Haze weather is for ordinary people, and maximum influence may be
Row inconvenience, but for the crowd with respiratory disease, what haze was brought is the puzzlement of Relapse rate breaking-out.Haze sky
Air in contain substantial amounts of pollutant and pathogenic microorganisms, intense stimulus can be caused to the respiratory tract of people, easily trigger various
Respiratory disease, it is common such as rhinitis, bronchitis, asthma, it more seriously can also trigger airway disorders to spread to lung
Portion, such as chronic obstructive pulmonary disease.Bronchial astehma typical clinical symptom, is that the ictal expiration with wheezing sound breathes tired
Difficulty, severe patient can be forced to take seat or in orthopnea, dry cough or cough up a large amount of white foam phlegm, or even cyanosis etc. occur.Roar
Breathing heavily symptom can break out in several minutes, through a few hours to a couple of days, be alleviated or spontaneous remission with after bronchodilators.Early stage is light
The most patients of disease show as ictal cough and uncomfortable in chest.The disease can be excited because of specificity and nonspecific stimulation, Qian Zheduo
For imbedibility antigen, such as pollen, mite dirt and mould；The latter such as histamine, acetylcholine, cold air and motion etc..
Asthma is the panting, have difficulty in breathing of recurrent exerbation, uncomfortable in chest or cough, more with contact allergen, cold air, physics,
Chemical irritation, viral infection of upper respiratory tract, motion etc. are relevant；During asthma attack double lung audibles and be dispersed in diffusivity, with
Wheezing sound based on expiratory phase, expiratory phase extension；Symptom can be relieved with antiasthmatic, or above-mentioned symptom can spontaneous remission.Remove
Outer other diseases may also cause pant, it is out of breath, uncomfortable in chest and cough.
The content of the invention
It is an object of the invention to provide a kind of biological agent, the biological agent is free from side effects to human body, safe and reliable, no
Produce dependence, the significant biological agent of effect, a kind of antibacterial peptide complex enzyme respiratory system spray of alternative antibiotic.
The purpose of the present invention is realized by the following manner：
A kind of antibacterial peptide complex enzyme oral spray, it is characterised in that：
The spray is made up of by mass percentage following composition：Main component：Antibacterial peptide 2-8%, lysozyme 15-
30%；Auxiliary material：Xylitol 5-7%, buffer solution 3-8%, sodium chloride 0.5~1%, bleeding agent 2-6%, remaining is ph values for 7.3~
7.5 alkalescent water or distilled water.
Buffer solution is potassium dihydrogen phosphate, and bleeding agent is AEO.
A kind of preparation method of antibacterial peptide complex enzyme respiratory system spray of the present invention and use are as follows：
Above-mentioned various composition is put into the alkalescent water that ph values are 7.3~7.5 according to corresponding proportioning or distilled water mixes equal
It is even, it is placed in medical respiration system spraying machine according to the situation of different crowd, is atomized 10~20 minutes every time.
Advantages of the present invention：
Nebulae inhalation is one of effective means of the upper respiratory condition such as prevention and Control of asthma, at present《Animal nutrition journal》
2014, Vol. 26 Issue (1)：The main function that 17-25 records antibacterial peptide is as follows：Antibacterial；Immunological regulation；Repair damage.
One produced in antibacterial peptide organism has the cationic polypeptide of strong antibacterial action, is the important of biological congenital immunity
Constituent, is made up of 20-60 amino acid, and molecular weight is 4000 dalton.
It is characterized in：Antibacterial peptide comes from neutrophil leucocyte, blood platelet etc., penetrates bacterial cell membrane, when cause of disease is invaded,
Expression can be induced, in animal body cortex, various mucus, be also distributed in enteron aisle mucus.
Its function is：Participate in killing pathogenic microorganism, with anti-bactericidal, virus, fungi, function of tumor；To AIDS
Virus and Blood protozoan also have killing action, and also regulation is with activating immunologic function etc. in addition.
Antibacterial peptide has broad spectrum antibiotic activity, can quickly killing target, and be wherein much pure natural peptide, make it
The therapeutic domain for rapidly becoming potential medicine # antibacterial peptides is:Gramnegative bacterium, gram-positive bacterium, fungi,
Parasite, tumour cell etc.；There is very strong lethal effect to bacterium, especially its killing action to some drug resistance pathogens
More cause the attention of people.
Antibacterial peptide is worked by acting on bacterial cell membrane.
Lysozyme is the native enzyme for being cloned using biotechnology, being extracted and being produced, by 130 or so amino acid
Composition, is small molecular protein, the dalton of molecular weight 14000.
The enzyme is widely present in human multiple tissue, the egg white of birds and poultry, the tear of mammal, saliva, blood plasma,
Also this enzyme is contained in the body fluid such as urine, milk and microorganism, wherein being enriched the most with egg white content.
Its property is：Lysozyme is very stable protein, there is stronger heat resistance；Will not because of organic solvent processing
And inactivate, when being transferred in the aqueous solution, the vigor of lysozyme can full recovery；Appropriate pH is 5.3 ~ 6.4, available for low in acidity
Food antiseptic；Antimicrobial spectrum is wider.
Lysozyme is faint yellow or white solid powder, the u/mg of pharmaceutical grade 20,000.With antibiotic property is strong, safety non-toxic, heat it is steady
The unique advantage such as qualitative good, sphere of action is wide.Lysozyme is a kind of hydrolase for being acting exclusively on microorganism wall, also known as thin
Lysozyme, with the pharmacological action such as anti-inflammation, antiviral, increase immunity, with good biocompatibility, to tissue nothing
The features such as stimulation, nontoxicity.It is used widely at present in medical domain, food production field.
Lysozyme is mainly characterized by：
1st, domestic initiation using lysozyme as additive application in the preventing and treating of disease, realize disease prevention and cure it is efficient, nontoxic, without residual
Stay, without withdrawal time.2nd, with anti-inflammatory, bacteriolyze, sterilization, the effects such as promoting body injury tissue repair and enhancing immunity of organisms,
Prevention effect is notable.From the point of view of to clinical prevention, efficient average prevention is more than 95%.Treated effect is up to more than 85%.3、
Has a broad antifungal spectrum：There is inhibitory or killing effect to pathogenic bacteria such as staphylococcus aureus, streptococcus, Escherichia coli and corynebacterium pyogeneses, it is right
Drug-fast bacteria has better effect.4th, the resistance to the action of a drug, drug resistance will not be caused.
The main function of lysozyme：
1st, the treatment and prevention of the diseases such as yellowish-white dysentery, enterogastritis are caused by bacteriums such as coccus, bacillus, effect is notable.It is 2nd, antiviral,
There is significant prevention effect to the viral disease in influenza, hyperpyrexia and breathing problem and aquatic animal.3 and antibiotic
There is synergistic function during class medicine drug combination, the consumption of antibiotic can be suitably reduced, to prevent drug-fast bacteria.
The mechanism of action of lysozyme：
1st, hydrolytic bacteria cell membrane, hinders the activity breeding of malignant bacteria, and kills pathogenic bacteria.The table in Gern morphology observation
Reveal very strong bacteriolysis, also there is bactericidal action while bacteriolyze.2nd, influenza and adenovirus can be prevented to breed, same to band
The virus protein of negative electrical charge is directly acted on, and with DNA, RNA, apoprotein formation double salt, is made virally inactivated.3rd, lysozyme conduct
One of body nospecific immunity factor, participates in the reaction of body panimmunity, in body normal defense function and nonspecific immunity
In, with the important function for keeping organism physiology balance.4th, with hematoblastic function is activated, local organization blood can be improved
Dyshaemia, decomposes dope, promotes the reparation of body injury tissue.
Lysozyme is a kind of protein, pH value change is relatively stablized, to thermally-stabilised under acid condition.By using biological work
Journey technology, regulatory protein pH value and spent ion exchange resin adsorbing separation and smart enzyme is made, enzyme activity is more than 1.8 ten thousand u/g, reaches
The standard of pharmaceutical grade.Lysozyme can dissolve bacterial cell, particularly to G+ bacterium（Gram-positive bacteria）There is strong effect, with anti-
The various properties of rhzomorph, because its glycoprotein to cell membrane walls（Mucinoid）Polysaccharide, with decomposition,
Decomposable asymmetric choice net chitin and ethylene glycol chitin, obtain carbonate, hydrochloride and nitrate crystallization etc..
The difference of antibacterial peptide and lysozyme：
Lysozyme and antibacterial peptide be all the two be all natural green product, drug resistance and medicament residue will not be produced, and be all
Cationic antimicrobial polypeptide, antibacterial peptide molecular weight is smaller than bacteriolyze enzyme molecular weight to be more easy to absorb.
Lysozyme is distributed widely in body fluid, mucus, focuses on anti-inflammatory, is an index of humans and animals immune level.It is anti-
Bacterium peptide is the Shou Dao defence lines of the animals and plants innate immunity, such as lower animal insect etc. without immune system and immune organ mainly by
Antibacterial peptide kills pathogenic microorganism.
Antibacterial peptide can stimulate the substantial amounts of lysozyme of generation, and effective to virus, fungi；Lysozyme is to virus, fungi
Do not work.Antibacterial peptide can be used with antibiotic compatibility, reach 2-8 times of synergy, and lysozyme can also match somebody with somebody with antibiotic
5 use.Antibacterial peptide and lysozyme compatibility are used, and reach 8-15 times of synergy.
The spray of the present invention is to combine antibacterial peptide and lysozyme as Main Ingredients and Appearance, is equipped with buffer solution, infiltration
Agent etc. effectively biotic component be composited, by atomization, by the conversion of the macromolecular of spray of the present invention be small molecule in,
Add medicine kills germ activity, can effectively control inflammation of upper respiratory tract, the beneficial bacterium in protection body, good stability, and
And will not develop immunity to drugs.And due to being bion oral spray, have no toxic side effect.
Embodiment
A kind of antibacterial peptide complex enzyme oral spray, it is characterised in that：
The spray is made up of by mass percentage following composition：Main component：Antibacterial peptide 2-8%, lysozyme 15-
30%；Auxiliary material：Xylitol 5-7%, buffer solution 3-8%, sodium chloride 0.5~1%, bleeding agent 2-6%, remaining is ph values for 7.3~
7.5 alkalescent water or distilled water.
Buffer solution is potassium dihydrogen phosphate, and bleeding agent is AEO.
A kind of preparation method of antibacterial peptide complex enzyme respiratory system spray of the present invention is as follows：
Above-mentioned various composition is put into the alkalescent water that pH value is 7.3~7.5 according to corresponding proportioning or distilled water mixes equal
It is even, it is placed in medical respiration system spraying machine, according to the situation of different crowd, is atomized 10~20 minutes every time.
Table 1 is all kinds of crowds using spray of the present invention.Numerical value in form is provided according to mass percent.
By above-described embodiment as can be seen that various inflammation of upper respiratory tract by using spray of the present invention after, obtain
Different degrees of improvement.
A kind of antibacterial peptide complex enzyme oral spray of the present invention, has effects that antibacterial, antiviral, raising immunity, with
Lysozyme compatibility synergy.The two is all the product of natural green, will not produce drug resistance and medicament residue trusts safely
Respiratory system spraying disinfection product.
Claims (3)
1. a kind of antibacterial peptide complex enzyme oral spray, it is characterized in that：
The spray is made up of by mass percentage following composition：Main component：Antibacterial peptide 2-8%, lysozyme 15-
30%；Auxiliary material：Xylitol 5-7%, buffer solution 3-8%, sodium chloride 0.5~1%, bleeding agent 2-6%, remaining be ph values be 7.3~
7.5 alkalescent water.
2. a kind of antibacterial peptide complex enzyme oral spray according to claim 1, it is characterized in that：Buffer solution is biphosphate
Potassium, bleeding agent is AEO.
3. a kind of antibacterial peptide complex enzyme respiratory system spray according to claim 1 or 2, its preparation method is as follows：
Various composition described in claim 1 or 2 is put into the alkalescent water that ph values are 7.3~7.5 according to corresponding proportioning and mixed
Close uniform, be placed in medical respiration system spraying machine, according to the situation of different crowd, be atomized 10~20 minutes every time.
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| CN201710156218.XA CN106938046A (en) | 2017-03-16 | 2017-03-16 | A kind of antibacterial peptide complex enzyme oral spray |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710156218.XA CN106938046A (en) | 2017-03-16 | 2017-03-16 | A kind of antibacterial peptide complex enzyme oral spray |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721122A (en) * | 2018-06-09 | 2018-11-02 | 江苏海尔滋生物科技有限公司 | A kind of canalis radicis dentis debridement, disinfection biogum biomaterial and preparation method thereof |
| CN111304181A (en) * | 2020-02-17 | 2020-06-19 | 华东理工大学 | A genetically engineered Vibrio parahaemolyticus phage lyase and its preparation method and application |
| CN112121105A (en) * | 2020-09-15 | 2020-12-25 | 长江大学 | Mouthwash spray for pets and preparation method thereof |
| CN113456518A (en) * | 2021-07-16 | 2021-10-01 | 北京洗得宝消毒制品有限公司 | Composite polypeptide mouthwash and preparation method thereof |
| CN113967251A (en) * | 2021-10-09 | 2022-01-25 | 山东凯普润消毒灭菌技术有限公司 | Bacteriostatic agent, hand sanitizer containing bacteriostatic agent and preparation method of hand sanitizer |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327854A (en) * | 2000-06-08 | 2001-12-26 | 上海高科生物工程有限公司 | Composite lysostaphin enzyme spray for oral cavity and its preparing process |
| CN1439427A (en) * | 2003-01-09 | 2003-09-03 | 长春奇龙生物技术研究所 | Use of gene recombination human lysozyme against drug resistant bacteria in preparation of medicine |
| CN1511586A (en) * | 2002-12-30 | 2004-07-14 | 上海高科联合生物技术研发有限公司 | Oral digestible film and its preparing process and use |
| US6830745B1 (en) * | 1997-10-16 | 2004-12-14 | Pharmacal Biotechnologies, Llc | Compositions for treating biofilm |
| CN1557485A (en) * | 2004-01-30 | 2004-12-29 | 大连帝恩生物工程有限公司 | Application of gene recombined human lysozyme in eliminating pathogenic microorganism infection |
| CN102085370A (en) * | 2011-01-28 | 2011-06-08 | 武汉耦合医学科技有限责任公司 | Oral spray for inflammatory diseases of oral cavity and preparation method thereof |
| CN102525856A (en) * | 2012-01-09 | 2012-07-04 | 江苏雪豹日化有限公司 | Biological compound enzyme oral spray and preparation method thereof |
| CN104524559A (en) * | 2014-12-16 | 2015-04-22 | 杨陈 | Lysostaphic complex enzyme oral cavity disinfectant and preparation method thereof |
| US20160074422A1 (en) * | 2013-05-08 | 2016-03-17 | Northeastern University | Mucus strengthening formulations to alter mucus barrier properties |
-
2017
- 2017-03-16 CN CN201710156218.XA patent/CN106938046A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830745B1 (en) * | 1997-10-16 | 2004-12-14 | Pharmacal Biotechnologies, Llc | Compositions for treating biofilm |
| CN1327854A (en) * | 2000-06-08 | 2001-12-26 | 上海高科生物工程有限公司 | Composite lysostaphin enzyme spray for oral cavity and its preparing process |
| CN1511586A (en) * | 2002-12-30 | 2004-07-14 | 上海高科联合生物技术研发有限公司 | Oral digestible film and its preparing process and use |
| CN1439427A (en) * | 2003-01-09 | 2003-09-03 | 长春奇龙生物技术研究所 | Use of gene recombination human lysozyme against drug resistant bacteria in preparation of medicine |
| CN1557485A (en) * | 2004-01-30 | 2004-12-29 | 大连帝恩生物工程有限公司 | Application of gene recombined human lysozyme in eliminating pathogenic microorganism infection |
| CN102085370A (en) * | 2011-01-28 | 2011-06-08 | 武汉耦合医学科技有限责任公司 | Oral spray for inflammatory diseases of oral cavity and preparation method thereof |
| CN102525856A (en) * | 2012-01-09 | 2012-07-04 | 江苏雪豹日化有限公司 | Biological compound enzyme oral spray and preparation method thereof |
| US20160074422A1 (en) * | 2013-05-08 | 2016-03-17 | Northeastern University | Mucus strengthening formulations to alter mucus barrier properties |
| CN104524559A (en) * | 2014-12-16 | 2015-04-22 | 杨陈 | Lysostaphic complex enzyme oral cavity disinfectant and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 欧阳萍: "人溶菌酶—抗菌肽融合表达及其对小鼠乳房炎的疗效观察", 《中国优秀硕士学位论文全文数据库农业科技辑》 * |
| 田晓乐等: "林蛙抗菌肽喷雾剂的制备及体外抑菌活性研究", 《中国药学杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721122A (en) * | 2018-06-09 | 2018-11-02 | 江苏海尔滋生物科技有限公司 | A kind of canalis radicis dentis debridement, disinfection biogum biomaterial and preparation method thereof |
| CN111304181A (en) * | 2020-02-17 | 2020-06-19 | 华东理工大学 | A genetically engineered Vibrio parahaemolyticus phage lyase and its preparation method and application |
| CN112121105A (en) * | 2020-09-15 | 2020-12-25 | 长江大学 | Mouthwash spray for pets and preparation method thereof |
| CN113456518A (en) * | 2021-07-16 | 2021-10-01 | 北京洗得宝消毒制品有限公司 | Composite polypeptide mouthwash and preparation method thereof |
| CN113967251A (en) * | 2021-10-09 | 2022-01-25 | 山东凯普润消毒灭菌技术有限公司 | Bacteriostatic agent, hand sanitizer containing bacteriostatic agent and preparation method of hand sanitizer |
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Application publication date: 20170711 |