CN106902461A - A kind of stimulus generator - Google Patents
A kind of stimulus generator Download PDFInfo
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- CN106902461A CN106902461A CN201710300010.0A CN201710300010A CN106902461A CN 106902461 A CN106902461 A CN 106902461A CN 201710300010 A CN201710300010 A CN 201710300010A CN 106902461 A CN106902461 A CN 106902461A
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- stimulus generator
- pulse
- electrode
- stimulating electrode
- triode
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- 230000004936 stimulating effect Effects 0.000 claims description 27
- 230000000638 stimulation Effects 0.000 claims description 20
- 230000008859 change Effects 0.000 claims description 9
- 230000008447 perception Effects 0.000 claims description 9
- 230000005611 electricity Effects 0.000 claims description 5
- 230000005405 multipole Effects 0.000 claims description 2
- 210000001367 artery Anatomy 0.000 claims 2
- 238000004080 punching Methods 0.000 claims 2
- 210000003462 vein Anatomy 0.000 claims 2
- 238000005424 photoluminescence Methods 0.000 claims 1
- 230000010287 polarization Effects 0.000 abstract description 6
- 206010067484 Adverse reaction Diseases 0.000 abstract description 2
- 230000006838 adverse reaction Effects 0.000 abstract description 2
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000006870 function Effects 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 7
- 210000004165 myocardium Anatomy 0.000 description 3
- 230000000661 pacemaking effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000001862 defibrillatory effect Effects 0.000 description 2
- 210000000578 peripheral nerve Anatomy 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000005404 monopole Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
- A61N1/0565—Electrode heads
- A61N1/0568—Electrode heads with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0587—Epicardial electrode systems; Endocardial electrodes piercing the pericardium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/3625—External stimulators
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention relates to medical instruments field, disclose a kind of stimulus generator, control circuit is perceived including at least two impulse output circuits and at least one, the stimulus generator alternately can provide boost pulse electric current in opposite direction, be equal to polarity of electrode checker and provide boost pulse.Polarity of electrode checker provides boost pulse and the histio-irritative adverse reaction of institute can be greatly decreased, reduce tissue polarity current potential and polarization impedance, stimulus threshold is reduced, while the convenient threshold value autocapture function for implementing stimulus generator, makes stimulus generator longer cell life.
Description
Technical field
The present invention relates to medical instruments field, in particular it relates to a kind of stimulus generator.
Background technology
Traditional cardiac stimulation system provides elicited by direct current pulse cardiac muscle using stimulating electrode as negative electrode, and electric current is from the moon
Pole is flowed out, and anode is flowed into after tissue, body fluid, forms loop.For this using fixed cathode electrode and direct current
Pulse paces the mode of heart tissue, can inevitably form polarization potential in electrode head end, produces polarization impedance, influence thorn
Swash threshold values.In the electrode using the small surface area of high impedance, polarization impedance can reach more than the 70% of whole system impedance, make
System pace-making efficiency reduction, the battery of pacemaker is easily exhausted.Meanwhile, Unidirectional direct-current pulse causes tissue reactive to increase, fine
Dimensionization degree increases, and have impact on the long-time stability of stimulation parameter.
In view of this, how further to improve stimulus generator, improving stimulates efficiency, reduction be stimulated tissue reactive and
Extend the battery life of stimulus generator, be that this area has technology to be solved to overcome the defect of above-mentioned traditional stimulating system
Problem.
The content of the invention
It is an object of the invention to provide a kind of stimulus generator, it is it is critical that improve stimulus generator granting
The pattern of boost pulse, reduces the polarization impedance of excitable tissue, reduces the battery of stimulus threshold and extension stimulus generator
Life-span；It is compared with conventional pacemaker, increased the position of the application of anode pace-making and pace-making.
The present invention is adopted the technical scheme that：
The invention provides a kind of stimulus generator.The stimulus generator includes at least two impulse output circuits and at least one
Control circuit is perceived, each electric stimulation pulse that the impulse output circuit is exported is single-phase ripple, is showed during alternate change
It is two single-phase and in opposite direction boost pulses；The control circuit that perceives is stimulated the level signal of body for perceiving and controls
Impulse output circuit processed sends pulse signal to the stimulating electrode.
Preferably, the electric stimulation pulse of the impulse output circuit is connected to stimulating electrode by triode and lead,
The control circuit that perceives is located between triode and stimulating electrode while being also electrically connected with the impulse output circuit respectively.
Preferably, the pulse signal output end of the impulse output circuit connects the base stage of the triode, triode
Emitter stage the stimulating electrode is connected by lead.This case triode preferentially uses NPN type triode.
Preferably, the control circuit that perceives includes perceiving unit and control unit, the perception unit is used for real-time
Receiving is stimulated the perception electrocardiosignal of body, and is sent to control unit, and control unit detects the effective of the electrocardiosignal
Property, and impulse output circuit sends polarity pulse signal to stimulating electrode according to the Polarity Control of the electrocardiosignal.
Preferably, multiple stimulating electrodes can be derived on the stimulating electrode, positioned at multiple stimulating electrodes of same one end
It is parallel with one another, to realize multipole reversal.
This stimulus generator can connect traditional monopole electrode, thus change conventional method using lead distal end electrode fix as
Negative electrode and the fixation of pacemaker shell as anode stimulation mode, traditional monopolar electrode can pierce alternately as negative electrode or anode
Swash cardiac muscle.
This stimulus generator can also be connected with traditional bipolar electrode, thus change conventional method and fix remote electrode
As negative electrode and annular electrode fixation as anode stimulation mode, remote electrode and annular electrode can alternately as negative electrode or
Anode excitation cardiac muscle.
This stimulus generator can be also used for the heart intramuscular electrode independent with two and be connected, and make this two electrodes only respectively
It is vertical to provide boost pulse, or boost pulse is provided respectively as negative electrode and anode joint, meanwhile, polarity of electrode can alternately become
Change.
Preferably, the stimulus generator that the present invention is provided includes：Double pulse generator, referred to as " double-core " stimulus generator,
Referred to as " double-core " pacemaker when being used in heart；And/or multipulse generator（≤ 3 impulse generators）Associated working
Pattern, referred to as " multinuclear " stimulus generator, referred to as " multinuclear " pacemaker when being used in heart.Described stimulus generator
Impulse stimulation electric current in opposite direction alternately can be provided, be equal to negative electrode and anode polarity alternate change.Described stimulation hair
The component connection circuit of raw device includes the connection circuit of any mode of pulse-pair output circuit or multiple-pulse output circuit.
Special instruction, the stimulus generator and Patent No. US4402322-A of present invention offer,
The stimulus generator that JP2001190695-A with US6341235 B1 are provided is different.Patent No. US4402322-A,
It is by two phase waves that the stimulus generator that JP2001190695-A and US6341235 B1 are provided sends out impulse stimulation（two-
Phase or biphase）The single boost pulse for constituting, its first phase and the second phase wave form, wave amplitude, time are different.And
Stimulus generator of the present invention sends out each impulse stimulation and is single-phase rectangular wave, and two single and directions are shown as during alternate change
Different boost pulses, pulsewidth and amplitude can be adjusted through program controller.
The stimulus generator that the present invention is provided alternately is provided electric pulse in opposite direction and is meant：Interval is certain or not etc.
Number of times or interval is certain or after time that do not wait, the electric pulse of granting different directions.
The stimulus generator sends out impulse stimulation and is single-phase, and feature includes showing as direction during alternate change different.
" double-core " and " multinuclear " stimulus generator or pacemaker that the present invention is provided, its function should not be understood merely as providing
Boost pulse, should also include：Perceptional function, diagnostic function and defibrillating function.
A kind of new electric stimulation pulse mode and/or " double-core " or " multinuclear " stimulus generator of present invention offer/
Or pacemaker：Preferably used in heart as one kind, but be not limited to heart, it is understood that being applicable outside any heart needs electricity
The tissue for stimulating and/or perceiving, such as：Blood vessel, brain and peripheral nerve etc..
The stimulus generator that the present invention is provided has following advantage compared with prior art：
The stimulus generator that the present invention is provided alternately can provide pulse current in opposite direction, and this is one kind that the present invention is provided
Brand-new electric stimulation pulse mode.Compared with one direction boost pulse, the stimulation of this checker pulse direction can be significantly
Degree reduces the histio-irritative adverse reaction of institute, reduces tissue polarity current potential and polarization impedance, reduces stimulus threshold, while convenient
Implement the threshold value autocapture function of stimulus generator, make the longer cell life of stimulus generator.
Brief description of the drawings
Accompanying drawing is, for providing a further understanding of the present invention, and to constitute the part of specification, with following tool
Body implementation method is used to explain the present invention together, but is not construed as limiting the invention.
Fig. 1 is the structure and operation principle block diagram of stimulus generator of the invention.
Fig. 2 is one kind " double-core " stimulus generator circuit catenation principle figure that the present invention is provided.
Specific embodiment
The present invention is described in detail with specific embodiment below in conjunction with the accompanying drawings.
Embodiment one.
As shown in figure 1, first aspect present invention provides a kind of stimulus generator, it includes at least two boost pulse
Output unit, at least one perceives and control unit.Such as Fig. 2, the pulse signal output end of the boost pulse output circuit leads to
Cross triode and lead is connected to the stimulating electrode, the perception control circuit is located between triode and stimulating electrode simultaneously
Also there is circuit with the boost pulse respectively to be electrically connected with, perceiving control circuit is used to perceive the level signal for being stimulated body simultaneously
Pulse signal is sent there is circuit to the stimulating electrode in control boost pulse.
One kind as the present embodiment is preferred, and the boost pulse occurs the pulse signal output end connection described three of circuit
The base stage of pole pipe, the emitter stage of triode connects the stimulating electrode by lead.The control circuit that perceives includes perceiving list
Unit and control unit, the perception unit are used for receiving in real time and are stimulated the perception electrocardiosignal of body, and are sent to control
Unit, control unit detects the validity of the electrocardiosignal, and the boost pulse hair according to the Polarity Control of the electrocardiosignal
Raw circuit sends polarity pulse signal to stimulating electrode.As shown in Fig. 2 multiple stimulation electricity can be derived on the stimulating electrode
Pole, the multiple stimulating electrodes positioned at same one end are parallel with one another, to realize multistage reversal.
Two boost pulse output circuits form double pulse generator associated working pattern, and referred to as " double-core " stimulation occurs
Device, referred to as " double-core " pacemaker when being used in heart；And/or multipulse generator（≤ 3 impulse generators）Associated working
Pattern, referred to as " multinuclear " stimulus generator, referred to as " multinuclear " pacemaker when being used in heart；The feature of the stimulus generator
Including：Pulse current in opposite direction can be alternately provided, i.e. boost pulse is provided in alternating polarity conversion.
Component connection circuit included by the stimulus generator that the present invention is provided should not be only understood shown in Fig. 2, it should managed
Solution is the connection circuit of any mode for including pulse-pair output circuit or multiple-pulse output circuit.
The stimulus generator that the present invention is provided alternately is provided electric pulse in opposite direction and is meant：Interval is certain or not etc.
Number of times or interval is certain or after time that do not wait, the electric pulse of granting different directions.
The stimulus generator sends out impulse stimulation and is single-phase, and feature includes showing as direction during alternate change different.
" double-core " and " multinuclear " stimulus generator or pacemaker that the present invention is provided, its function should not be understood merely as providing
Boost pulse, should also include：Perceptional function, diagnostic function and defibrillating function.
A kind of new electric stimulation pulse mode and/or " double-core " or " multinuclear " stimulus generator of present invention offer/
Or pacemaker：Preferably used in heart as one kind, but be not limited to heart, it is understood that being applicable outside any heart needs electricity
The tissue for stimulating and/or perceiving, such as：Blood vessel, brain and peripheral nerve etc..
The basic principles, principal features and advantages of the present invention have been shown and described above.One of ordinary skill in the art
It should be appreciated that the mode such as above-described embodiment protection domain that the invention is not limited in any way, all use equivalents is obtained
The technical scheme for obtaining, falls within protection scope of the present invention.
Part that the present invention does not relate to is same as the prior art or can be realized using prior art.
Claims (6)
1. a kind of stimulus generator, it is characterised in that perceive control electricity including at least two impulse output circuits and at least one
Road, each electric stimulation pulse that the impulse output circuit is exported is single-phase ripple, shown as during alternate change two it is single-phase
And boost pulse in opposite direction；The control circuit that perceives is stimulated the level signal of body for perceiving and controls pulse to export
Circuit sends pulse signal to the stimulating electrode.
2. a kind of stimulus generator according to claim 1, it is characterised in that the electro photoluminescence arteries and veins of the impulse output circuit
Punching is connected to stimulating electrode by triode and lead, and the perception control circuit is located between triode and stimulating electrode simultaneously
Also it is electrically connected with the impulse output circuit respectively.
3. a kind of stimulus generator according to claim 2, it is characterised in that the pulse signal of the impulse output circuit
Output end connects the base stage of the triode, and the emitter stage of triode connects the stimulating electrode by lead.
4. a kind of stimulus generator according to claim 1, it is characterised in that the perception control circuit includes perceiving single
Unit and control unit, the perception unit are used for receiving in real time and are stimulated the perception electrocardiosignal of body, and are sent to control
Unit, control unit detects the validity of the electrocardiosignal, and the pulse output electricity according to the Polarity Control of the electrocardiosignal
Road direction stimulating electrode sends polarity pulse signal.
5. a kind of stimulus generator according to Claims 2 or 3, it is characterised in that can be derived on the stimulating electrode many
Individual stimulating electrode, the multiple stimulating electrodes positioned at same one end are parallel with one another, to realize multipole reversal.
6. a kind of stimulus generator according to claim 1 or 2 or 3, it is characterised in that the stimulus generator can be used for
The interior electrode of the excitable tissue separate with two independence is connected, and two described interior electrodes is independently provided stimulation arteries and veins
Punching provides boost pulse respectively as negative electrode and anode joint, meanwhile, two polarities of electrode can realize checker.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710154785 | 2017-03-15 | ||
| CN2017101547851 | 2017-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106902461A true CN106902461A (en) | 2017-06-30 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710300148.0A Pending CN106994207A (en) | 2017-03-15 | 2017-05-02 | A kind of bipolar electrode sub-assembly and stimulating system |
| CN201710300010.0A Pending CN106902461A (en) | 2017-03-15 | 2017-05-02 | A kind of stimulus generator |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201710300148.0A Pending CN106994207A (en) | 2017-03-15 | 2017-05-02 | A kind of bipolar electrode sub-assembly and stimulating system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113631222A (en) * | 2019-03-12 | 2021-11-09 | Gs电子医疗设备G.斯坦普有限公司 | Stimulation device for electrotherapy and method of checking polarity of contact electrode |
| CN114392480A (en) * | 2022-02-18 | 2022-04-26 | 乐普医学电子仪器股份有限公司 | Circuit and method for generating bidirectional pulse of implanted pulse generator |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019169259A1 (en) * | 2018-03-02 | 2019-09-06 | Medtronic, Inc. | Implantable medical electrode assemblies and devices |
| CN112603524B (en) * | 2020-11-30 | 2023-02-24 | 杭州诺生医疗科技有限公司 | Interatrial septum tissue stoma device and interatrial septum group weaving mouth system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090240298A1 (en) * | 2008-03-18 | 2009-09-24 | Jie Lian | Switch polarity pacing to improve cardiac resynchronization therapy |
| CN103203076A (en) * | 2006-08-29 | 2013-07-17 | 心脏起搏器股份公司 | System for neural stimulation |
| CN208809312U (en) * | 2017-05-02 | 2019-05-03 | 刘志忠 | A kind of stimulus generator |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1428550A1 (en) * | 2002-12-13 | 2004-06-16 | P.A. & M. S.p.A. | Single pacemaker catheter electrode for the biventricular cardiac electrostimulation |
| AU2009236213B9 (en) * | 2008-04-15 | 2013-01-24 | Cardiac Pacemakers, Inc. | Bundle of His stimulation system |
| CN201329130Y (en) * | 2008-12-29 | 2009-10-21 | 陕西秦明医学仪器股份有限公司 | Bipolar electrode conduit for implanted cardiac pacemaker |
| AU2010337300B2 (en) * | 2009-12-31 | 2013-11-28 | Cardiac Pacemakers, Inc. | MRI safe, multipolar active fixation stimulation lead with co-radial construction |
| CN202289230U (en) * | 2011-07-28 | 2012-07-04 | 陕西秦明医学仪器股份有限公司 | Hormone spiral electrode catheter for implantable cardiac pacemaker |
-
2017
- 2017-05-02 CN CN201710300148.0A patent/CN106994207A/en active Pending
- 2017-05-02 CN CN201710300010.0A patent/CN106902461A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103203076A (en) * | 2006-08-29 | 2013-07-17 | 心脏起搏器股份公司 | System for neural stimulation |
| US20090240298A1 (en) * | 2008-03-18 | 2009-09-24 | Jie Lian | Switch polarity pacing to improve cardiac resynchronization therapy |
| CN208809312U (en) * | 2017-05-02 | 2019-05-03 | 刘志忠 | A kind of stimulus generator |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113631222A (en) * | 2019-03-12 | 2021-11-09 | Gs电子医疗设备G.斯坦普有限公司 | Stimulation device for electrotherapy and method of checking polarity of contact electrode |
| CN114392480A (en) * | 2022-02-18 | 2022-04-26 | 乐普医学电子仪器股份有限公司 | Circuit and method for generating bidirectional pulse of implanted pulse generator |
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|---|---|
| CN106994207A (en) | 2017-08-01 |
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